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Steven H. Lin, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2004 University of California, Irvine, CA, MD, Medicine
2004 University of California, Irvine, CA, PHD, Pharmacology
1995 University of California, Riverside, CA, MS, Biochemistry
1994 University of California, Riverside, CA, BS, Biology
1992 California Polytechnic University, Pomona, CA, None, Architecture (transferred)

Postgraduate Training

7/2005-8/2009 Clinical Residency, Radiation Oncology, The John Hopkins Hospital, Baltimore, MD, Ted L. DeWeese
7/2004-6/2005 Clinical Internship, Internal Medicine, Loma Linda University Medical Center, Loma Linda, CA
6/2001-7/2002 Post-Ph.D., Neuropharmacology, Neogene Technologies, Irvine, CA, Olivier Civelli

Board Certifications

5/2010 American Board of Radiology

Honors and Awards

2012-2014 Comparative Effectiveness Research on Cancer in Texas Fellow, CERCIT
2010-2013 ASTRO Junior Faculty Fellow, American Society for Radiation Oncology (ASTRO)
2008-2009 RSNA Research Resident Grant
2008 ABS/Nucletron HDR Brachytherapy Fellowship
2004 Alpha Omega Alpha, University of California, Irvine School of Medicine
2001 Henry Wood Elliott Award in Pharmacology
1998 American Heart Association Medical Student Fellowship
1997 UC Regents Research Fellowship
1996-1997 Dean's Award, University of California, Irvine School of Medicine
1996 Donald E. Pinder, M.D. Memorial Award
1996 Dr. Grace Bell Award
1995-2004 Medical Scientist Training Program Fellowship and Stipend
1994 Phi Beta Kappa, University of California
1994 Summa Cum Laude, University of California

Selected Publications

Peer-Reviewed Original Research Articles
1. Lin SH, George T, Ben-Josef E, Bradley J, Choe K, Edelman MJ, Guha C, Krishnan S, Lawrence T, Le QT, Lu B, Mehta M, Peereboom D, Sarkaria J, Seong J, Wang D, Welliver MX, Coleman N, Vikram B, Yoo S, Chung C. Opportunities and Challenges in the Era of Molecularly Targeted Agents and Radiation Therapy. The Journal of the National Cancer Institute. In Press.
2. Armini A, Feiran L, Corea AM, Baldessare R, Rimner A, Huang J, Roth JA, Swisher SG, Vaporciyan AA, Lin SH. Predictors for locoregional recurrence for clinical stage III-N2 non-small cell lung cancer with nodal downstaging after induction chemotherapy and surgery. Annals of Surgical Oncology. In Press.
3. Lin SH, Myles B, Wang L, Thall PF, Hofstetter WL, Swisher SG, Ajani JA, Cox JD, Komaki R, Liao Z. Propensity score based comparison of long term outcomes with 3D conformal radiotherapy (3DCRT) versus Intensity Modulated Radiation Therapy (IMRT) in treatment of esophageal cancer. Int J Radiat Oncol Biol Phy 84(5):1078-85, 12/2012. PMID: 22867894.
4. Xu T, Wei Q, Lopez Guerra JL, Wang LE, Liu Z, Gomez D, O'Reilly M, Lin SH, Zhuang Y, Levy LB, Mohan R, Zhou H, Liao Z. HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 84(2):e229-e235, 10/2012. e-Pub 5/2012. PMCID: PMC3426644.
5. Skinner HD, McCurdy MR, Echeverria AE, Lin SH, Welsh JW, O'Reilly MS, Hofstetter WL, Ajani JA, Komaki R, Cox JD, Sandulache VC, Myers JN, Guerrero TM. Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncol. e-Pub 9/2012. PMID: 22950385.
6. Taketa T, Correa AM, Suzuki A, Blum MA, Chien P, Lee JH, Welsh J, Lin SH, Maru DM, Erasmus JJ, Bhutani MS, Weston B, Rice DC, Vaporciyan AA, Hofstetter WL, Swisher SG, Ajani JA. Outcome of Trimodality-Eligible Esophagogastric Cancer Patients Who Declined Surgery after Preoperative Chemoradiation. Oncology 83(5). e-Pub 9/2012. PMID: 22964903.
7. Hayashi Y, Correa AM, Hofstetter WL, Vaporciyan AA, Mehran RJ, Rice DC, Suzuki A, Lee JH, Bhutani MS, Welsh J, Lin SH, Maru DM, Swisher SG, Ajani JA. Patients with high body mass index tend to have lower stage of esophageal carcinoma at diagnosis. Dis Esophagus 25(7):614-622, 9/2012. e-Pub 12/2011. PMID: 22150920.
8. Lopez Guerra JL, Gomez D, Zhuang Y, Hong DS, Heymach JV, Swisher SG, Lin SH, Komaki R, Cox JD, Liao Z. Prognostic Impact of Radiation Therapy to the Primary Tumor in Patients With Non-small Cell Lung Cancer and Oligometastasis at Diagnosis. Int J Radiat Oncol Biol Phys 84(1):e61-e67, 9/2012. e-Pub 4/2012. PMID: 22503522.
9. Lopez Guerra JL, Gomez DR, Lin SH, Levy LB, Zhuang Y, Komaki R, Jaen J, Vaporciyan AA, Swisher SG, Cox JD, Liao Z, Rice DC. Risk factors for local and regional recurrence in patients with resected N0-N1 non-small-cell lung cancer, with implications for patient selection for adjuvant radiation therapy. Ann Oncol. e-Pub 9/2012. PMID: 23002278.
10. Amini A, Correa AM, Komaki R, Chang JY, Tsao AS, Roth JA, Swisher SG, Rice DC, Vaporciyan AA, Lin SH. The Role of Consolidation Therapy for Stage III Non-Small Cell Lung Cancer With Persistent N2 Disease After Induction Chemotherapy. Ann Thorac Surg 94(3):914-920, 9/2012. e-Pub 7/2012. PMID: 22819472.
11. Yu ZH, Lin SH, Balter P, Zhang L, Dong L. A comparison of tumor motion characteristics between early stage and locally advanced stage lung cancers. Radiother Oncol 104(1):33-38, 7/2012. e-Pub 6/2012. PMID: 22677039.
12. Hayashi Y, Xiao L, Suzuki A, Blum MA, Sabloff B, Taketa T, Maru DM, Welsh J, Lin SH, Weston B, Lee JH, Bhutani MS, Hofstetter WL, Swisher SG, Ajani JA. A nomogram associated with high probability of malignant nodes in the surgical specimen after trimodality therapy of patients with oesophageal cancer. Eur J Cancer. e-Pub 7/2012. PMID: 22853875.
13. Ajani JA, Correa AM, Hofstetter WL, Rice DC, Blum MA, Suzuki A, Taketa T, Welsh J, Lin SH, Lee JH, Bhutani MS, Ross WA, Maru DM, Macapinlac HA, Erasmus J, Komaki R, Mehran RJ, Vaporciyan AA, Swisher SG. Clinical parameters model for predicting pathologic complete response following preoperative chemoradiation in patients with esophageal cancer. Ann Oncol. e-Pub 7/2012. PMID: 22831985.
14. Lin SH, Komaki R, Liao Z, Wei C, Myles B, Guo X, Palmer M, Mohan R, Swisher SG, Hofstetter WL, Ajani JA, Cox JD. Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer. Int J Radiat Oncol Biol Phys 83(3):e345-e351, 7/2012. e-Pub 3/2012. PMID: 22417808.
15. Wang J, Lin SH, Dong L, Balter P, Mohan R, Komaki R, Cox JD, Starkschall G. Quantifying the Interfractional Displacement of the Gastroesophageal Junction during Radiation Therapy for Esophageal Cancer. Int J Radiat Oncol Biol Phys 83(2):e273-e280, 6/2012. e-Pub 3/2012. PMID: 22440040.
16. Suzuki A, Xiao L, Hayashi Y, Macapinlac HA, Welsh J, Lin SH, Lee JH, Bhutani MS, Maru DM, Hofstetter WL, Swisher SG, Ajani JA. Prognostic significance of baseline positron emission tomography and importance of clinical complete response in patients with esophageal or gastroesophageal junction cancer treated with definitive chemoradiotherapy. Cancer 117(21):4822-33, 11/1/2011. e-Pub 3/31/2011. PMCID: PMC3144261.
17. Hristov B, Reddy S, Lin SH, Cameron JL, Pawlik TM, Hruban RH, Swartz MJ, Edil BH, Kemp C, Wolfgang CL, Herman JM. Outcomes of adjuvant chemoradiation after pancreaticoduodenectomy with mesenterico-portal vein resection for adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys 76(1):176-80, 1/2010. PMID: 19394156.
18. Tan AC, Jimeno A, Lin SH, Wheelhouse J, Chan F, Solomon A, Rajeshkumar NV, Rubio-Viqueira B, Hidalgo M. Characterizing DNA methylation patterns in pancreatic cancer genome. Mol Oncol 3(5-6):425-38, 12/2009. e-Pub 4/2009. PMID: 19497796.
19. Yi JM, Tsai HC, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB. Abnormal DNA methylation of CD133 in Colorectal and Glioblastoma Tumors. Cancer Res 68(19):8094-8103, 10/1/2008. PMCID: PMC2744404.
20. Lin SH, Sugar E, Teslow T, McNutt T, Saleh H, Song DY. Comparison of daily couch shifts using MVCT (TomoTherapy) and B-mode Ultrasound (BAT system) during prostate radiotherapy. Technol Cancer Res Treat 7(4):279-286, 8/2008. PMID: 18642966.
21. Lin SH, Kleinberg LR. Carmustine Wafers: Localized delivery of chemotherapeutic agents in CNS malignancies. Expert Rev Anticancer Ther 8(3):343-359, 3/2008. PMID: 18366283.
22. Lin SH, Latronico D, Teslow T, Bajaj GK. A highly reproducible bolus immobilization technique for the treatment of scalp malignancies. Med Dosim 33(1):30-35, 2008. PMID: 18262120.
23. Lin SH. Prolactin Releasing Peptide. Results Probl Cell Differ 46:57-88, 2008. PMID: 18204826.
24. Nagasaki H, Wang Z, Jackson VR, Lin S, Nothacker HP, Civelli O. Differential expression of the thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat pituitary. J Mol Endocrinol 37(1):39-50, 8/2006. PMID: 16901922.
25. Jackson VR, Lin SH, Wang Z, Nothacker HP, Civelli O. A study of the rat neuropeptide B/neuropeptide W system using in situ techniques. J Comp Neurol 497(3):367-383, 7/20/2006. PMID: 16736466.
26. Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron 43(4):487-497, 8/19/2004. PMID: 15312648.
27. Lin SH, Civelli O. Orphan G protein-coupled receptors: targets for new therapeutic interventions. Ann Med 36(3):204-214, 2004. PMID: 15181976.
28. Lin SH, Leslie FM, Civelli O. Neurochemical properties of the PrRP receptor expressing neurons: Evidence for a role as a regulator of stress and nociception. Brain Res 952:15-30, 2002. PMCID: PMC12363400.
29. Civelli O, Nothacker HP, Saito Y, Wang Z, Lin SH, Reinscheid RK. Novel neurotransmitters as natural ligands of orphan G protein-coupled receptors. Trends Neurosci 24(4):230-237, 4/2001. PMID: 11250008.
30. Lin SH, Arai A, Wang Z, Nothacker HP, Civelli O. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in a-amino3- hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. Mol Pharmacol 60:916-924, 2001. PMCID: PMC11641419.
31. Nothacker HP, Wang Z, Zhu Y, Reinscheid RK, Lin SH, Civelli O. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol 58(6):1601-1608, 2000. PMCID: PMC1193801.
32. Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, Civelli O. Molecular characterization of the melanin-concentrating hormone receptor. Nature 400(400):265-269, 7/1999. PMID: 10421368.

Book Chapters
1. Lin SH, Liao Z. Esophageal Cancer. In: Decision Making in Radiation Oncology, 2. Ed(s) Lu JJ, Brady LW. Springer-Verlag: Heidelberg, Germany, 329-358, 2010.
2. Lin SH, Chang JY. Lung Cancer. In: Decision Making in Radiation Oncology, 2. Ed(s) Lu JJ, Brady LW. Springer-Verlag: Heidelberg, Germany, 261-307, 2010.
3. Hristov B, Lin SH, Christodouleas JP. Rhabdomyosarcoma. In: Radiation Oncology A Question-Based Review. Wolters Kluwer/Lippincott Williams & Wilkins: Philadelphia, PA, 1-12, 2010.
4. Lin SH, Wharam, Jr. MD. Wilms Tumor. In: Radiation Oncology A Question-Based Review. Wolters Kluwer/Lippincott Williams & Wilkins: Philadelpha, PA, 20-30, 2010.

Grant & Contract Support

Title: Randomized Phase II Trial 2012-0017
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 7/1/1986 - 4/30/2014

Last updated: 2/11/2013