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Steven G. Waguespack, M.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Pediatrics Patient Care, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Steven Waguespack is a Professor of internal medicine and pediatrics at the University of Texas MD Anderson Cancer Center in Houston. A native of Louisiana, Dr. Waguespack graduated summa cum laude from Loyola University in New Orleans, where he also participated in the presidential scholars honor program. He graduated from the University of Texas Medical School at Houston with honors and pursued training in internal medicine/pediatrics at the Indiana University Medical Center in Indianapolis. He completed a combined adult and pediatric endocrinology fellowship at Indiana University and is board certified in both subspecialties. Recognized as one of "America's Top Doctors for Cancer" in endocrinology, his major clinical and research interests are thyroid cancer, pituitary tumors, and genetic syndromes of endocrine neoplasia. At MD Anderson, where he has been on faculty since 2002, Dr. Waguespack enjoys providing endocrine care to patients of all ages.

Research Interests

Thyroid Cancer, Pituitary Tumors, Multiple Endocrine Neoplasia, and Pediatric Endocrine Tumors

Clinical Interests

Thyroid Cancer, Pituitary Tumors, Multiple Endocrine Neoplasia, and Pediatric Endocrine Tumors

For general clinic information and referrals, please visit the Department of Endocrine Neoplasia and Hormonal Disorders' contact information webpage at:

 Contact Information 

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street
Unit Number: 1461
Houston, TX 77030-3722
Room Number: FCT12.5030
Phone: (713) 792-2841
Fax: (713) 794-4065

Education & Training

Degree-Granting Education

1994 University of Texas Medical School at Houston, Houston, TX, MD, Medicine
1990 Loyola University, New Orleans, LA, BS, Summa cum laude, Presidential Scholar, Biology

Postgraduate Training

6/1998-6/2002 Fellowship, Adult and Pediatric Endocrinology, Indiana University Medical Center, Indianapolis, IN
6/1994-6/1998 Internship and Residency, Internal Medicine/ Pediatrics, Indiana University Medical Center, Indianapolis, IN

Board Certifications

8/2003 Pediatric Endocrinology, Recertification Date: 3/2013
11/2002 Endocrinology, Diabetes, and Metabolism, Recertification Date: 10/2012


Administrative Appointments/Responsibilities

Deputy Department Chair, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, 6/2010-present

Honors and Awards

2015-2016 Best Doctors in America, Best Doctors, Inc.
2015 Castle Connolly America's Top Doctors
2012 Compassionate Doctor Recognition
2005 Fellow, American College of Endocrinology
2005 Fellow, American Academy of Pediatrics
2002 Richard B. Schnute Award in recognition of outstanding compassion, professionalism, and clinical care as exemplified by Dr. Schnute, Indiana University School of Medicine
1994 Walter G. Sterling Award for Excellence, University of Texas Medical School at Houston
1990 The Ruth & Lee Faust Award for outstanding academic achievement by a graduate in biological sciences, Loyola University

Professional Memberships

Alpha Omega Alpha Honor Medical Society
Member, 1993-present
American Association of Clinical Endocrinologists
Member, 2002-present
American Thyroid Association
Member, Medullary Thyroid Cancer Guidelines Committee, 11/2012-3/2015
Member, ATA Task Force on Childhood Thyroid Cancer Treatment Guidelines, 8/2009-4/2015
Member, 2008-present
National Cancer Comprehensive Network, Fort Washington, PA
Member, NCCN Thyroid Carcinoma Panel, 2007-2014
Pediatric Endocrine Society (formerly known as the Lawson Wilkins Pediatric Endocrine Society)
Member, 1999-present
The Endocrine Society
Member, 1999-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Yip L, Lee JE, Shapiro SE, Waguespack SG, Sherman SI, Hoff AO, Gagel RF, Arens JF, Evans DB. Surgical management of hereditary pheochromocytoma. J Am Coll Surg 198(4):525-34; discussion 534-5, 4/2004. PMID: 15051000.
2. Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, Asper JA, Diaz EM, Evans DB, Gagel RF, Garden A, Hoff AO, Lee JE, Morrison WH, Rosenthal DI, Sherman SI, Sturgis EM, Waguespack SG, Weber RS, Wirfel K, Vassilopoulou-Sellin R. Parathyroid carcinoma: a 22-year experience. Head Neck 26(8):716-26, 8/2004. PMID: 15287039.
3. Kouvaraki MA, Shapiro SE, Cote GJ, Lee JE, Yao JC, Waguespack SG, Gagel RF, Evans DB, Perrier ND. Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. World J Surg 30(5):643-53, 5/2006. PMID: 16680581.
4. Waguespack SG, Hui SL, Dimeglio LA, Econs MJ. Autosomal Dominant Osteopetrosis: Clinical Severity and Natural History of 94 Subjects with a Chloride Channel 7 Gene Mutation. J Clin Endocrinol Metab 92(3):771-8, 3/2007. e-Pub 12/2006. PMID: 17164308.
5. Shaw SA, Camacho LH, McCutcheon IE, Waguespack SG. Transient Hypophysitis after Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA4) Blockade. J Clin Endocrinol Metab 92(4):1201-2, 4/2007. PMID: 17409339.
6. Wray CJ, Rich TA, Waguespack SG, Lee JE, Perrier ND, Evans DB. Failure to recognize multiple endocrine neoplasia 2b: more common than we think? Ann Surg Oncol 15(1):293-301, 1/2008. e-Pub 10/2007. PMID: 17963006.
7. Jimenez C, Cabanillas ME, Santarpia L, Jonasch E, Kyle KL, Lano EA, Matin SF, Nunez RF, Perrier ND, Phan A, Rich TA, Shah B, Williams MD, Waguespack SG. Use of the Tyrosine Kinase Inhibitor Sunitinib in a Patient with von Hippel-Lindau Disease: Targeting Angiogenic Factors in Pheochromocytoma and other von Hippel-Lindau Disease-related Tumors. J Clin Endocrinol Metab (*Cover Illustration) 94(2):386-91, 2/2009. e-Pub 11/2008. PMID: 19017755.
8. Waguespack SG, Williams MD, Clayman GL, Herzog CE. The Successful Use of Sorafenib to Treat Pediatric Papillary Thyroid Carcinoma. Thyroid 19(4):407-12, 4/2009. PMID: 19355831.
9. Waguespack SG, Rich T, Grubbs E, Ying AK, Perrier ND, Ayala-Ramirez M, Jimenez C. A Current Review of the Etiology, Diagnosis, and Treatment of Pediatric Pheochromocytoma and Paraganglioma. J Clin Endocrinol Metab 95(5):2023-37, 5/2010. e-Pub 3/2010. PMID: 20215394.
10. Amhaz HH, Chamoun RB, Waguespack SG, Shah K, McCutcheon IE. Spontaneous involution of Rathke cleft cysts: is it rare or just underreported? J Neurosurg 112(6):1327-32, 6/2010. e-Pub 11/2009. PMID: 19929199.
11. Cabanillas ME, Waguespack SG, Bronstein Y, Williams MD, Feng L, Hernandez M, Lopez A, Sherman SI, Busaidy NL. Treatment with Tyrosine Kinase Inhibitors for Patients with Differentiated Thyroid Cancer: the M. D. Anderson Experience. J Clin Endocrinol Metab 95(6):2588-95, 6/2010. e-Pub 4/2010. PMID: 20392874.
12. Grubbs EG, Waguespack SG, Rich TA, Xing Y, Ying AK, Evans DB, Lee JE, Perrier ND. Do the recent American Thyroid Association (ATA) Guidelines accurately guide the timing of prophylactic thyroidectomy in MEN2A? Surgery 148(6):1302-10, 12/2010. PMID: 21134565.
13. Jasim S, Ying AK, Waguespack SG, Rich TA, Grubbs EG, Jimenez C, Hu MI, Cote G, Habra MA. Multiple endocrine neoplasia type 2B with a RET proto-oncogene A883F mutation displays a more indolent form of medullary thyroid carcinoma compared with a RET M918T mutation. Thyroid 21(2):189-92, 2/2011. e-Pub 12/27/2010. PMCID: PMC3025175.
14. Ayala-Ramirez M, Feng L, Johnson MM, Ejaz S, Habra MA, Rich T, Busaidy N, Cote GJ, Perrier N, Phan A, Patel S, Waguespack S, Jimenez C. Clinical Risk Factors for Malignancy and Overall Survival in Patients with Pheochromocytomas and Sympathetic Paragangliomas: Primary Tumor Size and Primary Tumor Location as Prognostic Indicators. J Clin Endocrinol Metab 96(3):717-25, 3/2011. e-Pub 12/29/2010. PMID: 21190975.
15. Ejaz S, Vassilopoulou-Sellin R, Busaidy NL, Hu MI, Waguespack SG, Jimenez C, Ying AK, Cabanillas M, Abbara M, Habra MA. Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion: The University of Texas MD Anderson Cancer Center Experience. Cancer 117(19):4381-9, 10/1/2011. e-Pub 3/15/2011. PMCID: PMC3134535.
16. Hong DS, Cabanillas ME, Wheler J, Naing A, Tsimberidou AM, Ye L, Waguespack SG, Hernandez M, El Naggar AK, Bidyasar S, Wright J, Sherman SI, Kurzrock R. Inhibition of the Ras/Raf/MEK/ERK and RET Kinase Pathways with the Combination of the Multikinase Inhibitor Sorafenib and the Farnesyltransferase Inhibitor Tipifarnib in Medullary and Differentiated Thyroid Malignancies. J Clin Endocrinol Metab 96(4):997-1005, 4/2011. e-Pub 2/2/2011. PMCID: PMC3070247.
17. Khan MI, Habra MA, McCutcheon IE, Nogueras-González GM, Devin JK, Busaidy NL, Levine NB, Lindstrom W, Kagan D, Jimenez C, Waguespack SG. Random postoperative day 3 cortisol as a predictor of hypothalamic-pituitary-adrenal axis integrity after transsphenoidal surgery. Endocr Pract 17(5):1-25, 9/1/2011. e-Pub 3/2011. PMID: 21454228.
18. Stephen MD, Zage PE, Waguespack SG. Gonadotropin-Dependent Precocious Puberty: Neoplastic Causes and Endocrine Considerations. Int J Pediatr Endocrinol (*article selected and evaluated by the Faculty of 1000) 2011(Article ID 184502):184502, 2011. e-Pub 3/2011. PMCID: PMC3095257.
19. Hightower E, Cabanillas ME, Fuller GN, McCutcheon IE, Hess KR, Shah K, Waguespack SG, Corley LJ, Devin JK. Phospho-histone H3 (pHH3) immuno-reactivity as a prognostic marker in non-functioning pituitary adenomas. Pituitary 15(4):556-61, 12/2012. e-Pub 11/2011. PMID: 22120760.
20. Clayman GL, Agarwal G, Edeiken BS, Waguespack SG, Roberts DB, Sherman SI. Long-term outcome of comprehensive central compartment dissection in patients with recurrent/persistent papillary thyroid carcinoma. Thyroid 21(12):1309-16, 12/2011. PMID: 22136266.
21. Jonasch E, McCutcheon IE, Waguespack SG, Wen S, Davis DW, Smith LA, Tannir NM, Gombos DS, Fuller GN, Matin SF. Pilot trial of sunitinib therapy in patients with von Hippel-Lindau disease. Ann Oncol 22(12):2661-6, 12/2011. PMID: 22105611.
22. Morris LF, Waguespack SG, Edeiken-Monroe BS, Lee JE, Rich TA, Ying AK, Warneke CL, Evans DB, Perrier ND, Grubbs EG. Ultrasonography Should Not Guide the Timing of Thyroidectomy in Pediatric Patients Diagnosed with Multiple Endocrine Neoplasia Syndrome 2A through Genetic Screening. Ann Surg Oncol 20(1):53-9, 1/2013. e-Pub 8/2012. PMID: 22890595.
23. Morris LF, Waguespack SG, Warneke CL, Ryu H, Ying AK, Anderson BJ, Sturgis EM, Clayman GL, Lee JE, Evans DB, Grubbs EG, Perrier ND. Long-Term Follow- Up Data May Help Manage Patient and Parent Expectations for Pediatric Patients Undergoing Thyroidectomy. Surgery 152(6):1165-71, 12/2012. PMID: 23158186.
24. Carhill AA, Cabanillas ME, Jimenez C, Waguespack SG, Habra MA, Hu M, Ying A, Vassilopoulou-Sellin R, Gagel RF, Sherman SI, Busaidy NL. The Non-investigational Use of Tyrosine Kinase inhibitors in Thyroid Cancer: Establishing a Standard for Patient Safety and Monitoring. J Clin Endocrinol Metab 98(1):31-42, 1/2013. e-Pub 11/2012. PMCID: PMC3537108.
25. Shawa H, Elsayes KM, Javadi S, Morani A, Williams MD, Lee JE, Waguespack SG, Busaidy NL, Vassilopoulou-Sellin R, Jimenez C, Habra MA. Adrenal ganglioneuroma: features and outcomes of 27 cases at a referral cancer centre. Clin Endocrinol (Oxf) 80(3):342-7, 3/2014. e-Pub 9/18/2013. PMID: 24033606.
26. Thosani S, Ayala-Ramirez M, Palmer L, Hu MI, Rich T, Gagel RF, Cote G, Waguespack SG, Habra MA, Jimenez C. The Characterization of Pheochromocytoma and Its Impact on Overall Survival in Multiple Endocrine Neoplasia Type 2. J Clin Endocrinol Metab 98(11):E1813-9, 11/2013. e-Pub 9/12/2013. PMID: 24030942.
27. Verma J, McCutcheon IE, Waguespack SG, Mahajan A. Feasibility and outcome of re-irradiation in the treatment of multiply recurrent pituitary adenomas. Pituitary 17(6):539-45, 12/2014. e-Pub 11/2013. PMID: 24272035.
28. Morris LF, Harris RS, Milton DR, Waguespack SG, Habra MA, Jimenez C, Vassilopoulou-Sellin R, Lee JE, Perrier ND, Grubbs EG. Impact and timing of bilateral adrenalectomy for refractory adrenocorticotropic hormone-dependent Cushing s syndrome. Surgery 154(6):1174-83; discussion 1183-4, 12/2013. PMID: 24383115.
29. Rich TA, Feng L, Busaidy N, Cote GJ, Gagel RF, Hu M, Jimenez C, Lee JE, Perrier N, Sherman SI, Waguespack SG, Ying A, Grubbs E. Prevalence by Age and Predictors of Medullary Thyroid Cancer in Patients with Lower Risk Germline RET Proto-Oncogene Mutations. Thyroid 24(7):1096-106, 7/2014. e-Pub 6/2014. PMCID: PMC4080849.
30. Dadu R, Devine C, Hernandez M, Waguespack SG, Busaidy NL, Hu MI, Jimenez C, Habra MA, Sellin RV, Ying AK, Cote GJ, Sherman SI, Cabanillas ME. Role of salvage targeted therapy in differentiated thyroid cancer patients who failed first-line sorafenib. J Clin Endocrinol Metab 99(6):jc20133588, 6/2014. e-Pub 3/2014. PMCID: PMC4037722.
31. Romero Arenas MA, Morris LF, Rich TA, Cote GJ, Grubbs EG, Waguespack SG, Perrier ND. Preoperative multiple endocrine neoplasia type 1 diagnosis improves the surgical outcomes of pediatric patients with primary hyperparathyroidism. J Pediatr Surg 49(4):546-50, 4/2014. e-Pub 11/2013. PMID: 24726110.
32. Falchook GS, Millward M, Hong D, Naing A, Piha-Paul S, Waguespack SG, Cabanillas ME, Sherman SI, Ma B, Curtis M, Goodman V, Kurzrock R. BRAF Inhibitor Dabrafenib in Patients with Metastatic BRAF-Mutant Thyroid Cancer. Thyroid 25(1):71-7, 1/2015. PMCID: PMC4291160.
33. Wells SA, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Schlumberger M, Shah M, Waguespack SG. Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma The American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma. Thyroid 25(6):567-610, 6/2015. e-Pub 3/2015. PMID: 25810047.
34. Raman S, Grimberg A, Waguespack SG, Miller BS, Sklar CA, Meacham LR, Patterson BC. Risk of Neoplasia in Pediatric Patients Receiving Growth Hormone Therapy - A Report from the Pediatric Endocrine Society Drug and Therapeutics Committee. J Clin Endocrinol Metab 100(6):jc20151002, 6/2015. e-Pub 4/2015. PMID: 25839904.
35. Francis G, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti J, Dinauer CA, Hamilton JK, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson G, Yamashita S. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Pediatric Thyroid Cancer. Thyroid. e-Pub 4/2015. PMID: 25900731.

Invited Articles

1. Tuttle RM, Haddad RI, Ball DW, Byrd D, Dickson P, Duh QY, Ehya H, Haymart M, Hoh C, Hunt JP, Iagaru A, Kandeel F, Kopp P, Lamonica DM, Lydiatt WM, McCaffrey J, Moley JF, Parks L, Raeburn CD, Ridge JA, Ringel MD, Scheri RP, Shah JP, Sherman SI, Sturgeon C, Waguespack SG, Wang TN, Wirth LJ, Hoffmann KG, Hughes M. Thyroid carcinoma, version 2.2014. J Natl Compr Canc Netw 12(12):1671-80; quiz 1680, 12/2014. PMID: 25505208.
2. Kalkan E, Waguespack SG. Endocrine Tumors Associated with Neurofibromatosis Type 1, Peutz- Jeghers Syndrome and Other Familial Neoplasia Syndromes. Front Horm Res 41:166-181, 2013. e-Pub 3/2013. PMID: 23652677.
3. Waguespack SG, Rich TA, Perrier ND, Jimenez C, Cote GJ. Management of medullary thyroid carcinoma and MEN2 syndromes in childhood. (Selected as a Medscape CME article). Nat Rev Endocrinol 7(10):596-607, 10/2011. e-Pub 8/2011. PMID: 21862994.
4. Khan MI, Waguespack SG, Hu MI. Medical Management of Postsurgical Hypoparathyroidism. Endocr Pract 17 Suppl 1:1-19, Mar-Apr, 3/2011. e-Pub 12/2010. PMID: 21134871.
5. Francis G and Waguespack SG. An Individualized Approach to the Child With Thyroid Cancer. Expert Review of Endocrinology & Metabolism 6(1):85-92, 1/2011.
6. Waguespack SG, Francis G. Initial Management and Follow-up of Differentiated Thyroid Cancer in Children. J Natl Compr Canc Netw 8(11):1289-1300, 11/2010. PMID: 21081785.
7. Ying AK, Huh W, Bottomley S, Evans DB, Waguespack SG. Thyroid cancer in young adults. Semin Oncol 36(3):258-74, 6/2009. PMID: 19460583.
8. Rich TA, Hu MI, Martin JW, Perrier ND, Waguespack SG. CDC73-Related Disorders [Includes: CDC73-Related Familial Isolated Hyperparathyroidism, Hyperparathyroidism-Jaw Tumor Syndrome, CDC73-Related Parathyroid Carcinoma] [Last Update May 24, 2012]. In: Pagon RA, Bird TC, Dolan CR, Stephens K, editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-. e-Pub 12/2008. PMID: 20301744.


1. Jimenez C, Waguespack SG. Functional imaging for pheochromocytoma-paraganglioma: a step closer to understanding its place in clinical practice. Endocrine. e-Pub 6/2015. PMID: 26113425.
2. Waguespack SG. A perspective from pediatric endocrinology on the hereditary medullary thyroid carcinoma syndromes. Thyroid 19(6):543-6, 6/2009. PMID: 19499985.

Book Chapters

1. Waguespack S, Wells S, Ross J, Bleyer A. Thyroid Cancer. In: Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000. Ed(s) Bleyer A, O'Leary M, Barr R, Ries LAG. National Cancer Institute, NIH Pub No 06-5767: Bethesda, MD, 143-54, 2006.
2. Waguespack S, Wells SA. Thyroid Carcinoma. In: Cancer in Adolescents and Young Adults. 1. Ed(s) Bleyer A and Barr R. Springer Verlag, 259-68, 2007. ISBN: 978-3-540-40842-0.
3. Bauer AJ, Waguespack SG, Grover A, Francis GL. Thyroid Neoplasia. In: Pediatric Endocrinology: A Practical Clinical Guide, 2nd. Ed(s) S Radovick, M MacGillivray. Humana Press, 319-338, 2013.
4. Waguespack SG, Grubbs EG, Hu MI. Multiple Endocrine Neoplasia Type 2. In: Clinical Genomics: Practical Applications in Adult Patient Care, 1st. Ed(s) MF Murray, MW Babyatsky, MA Giovanni. McGraw Hill Education, 278-283, 2014. ISBN: 978-0-07-162244-8.
5. Waguespack SG and Ying AK. Pheochromocytoma and Multiple Endocrine Neoplasia Syndromes. In: Pediatric Endocrinology, 4th. Ed(s) MA Sperling. Elsevier: Philadelphia, 533-568, 2014.
6. Waguespack SG. Chapter 506.1 Thyroid Tumors, Chapter 506.5 Adrenal Tumors. In: Nelson Textbook of Pediatrics, 20th edition. Ed(s) RM Kliegman, BF Stanton, JW St. Geme, NF Schor. Elsevier, Inc: Philadelphia, 2015.
7. Waguespack SG, Huh W, Bauer AJ. Chapter 36 Endocrine Tumors. In: Principles and Practice of Pediatric Oncology, 7th. Ed(s) PA Pizzo and DG Poplack. Lippincott Williams & Wilkins, 2015.

Letters to the Editor

1. Waguespack SG, Bauer AJ, Francis GL, Vassilopoulou-Sellin R. Radioactive Iodine for Pediatric Differentiated Thyroid Carcinoma: Sometimes "Less is More". J Clin Endocrinol Metab,, 10/2011.
2. Waguespack SG, Rich TA. Multiple endocrine neoplasia syndrome type 2B in early childhood: long-term benefit of prophylactic thyroidectomy. Cancer 116(9):2284, 5/2010. e-Pub 2/2010. PMID: 20166211.


1. Web-based CME Activity. "Mini-Case: Signs, Symptoms, and Treatment of Acromegaly in Adults." A Medscape CME Activity. August 29, 2011.

Last updated: 7/1/2015