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Steven G. Waguespack, M.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Pediatrics Patient Care, Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Steven Waguespack is an associate professor of internal medicine and pediatrics at the University of Texas M. D. Anderson Cancer Center in Houston. A native of Louisiana, Dr. Waguespack graduated summa cum laude from Loyola University in New Orleans, where he also participated in the presidential scholars honor program. He graduated from the University of Texas-Houston Medical School with honors and pursued training in internal medicine/pediatrics at Indiana University Medical Center in Indianapolis. He completed a combined adult and pediatric endocrinology fellowship at Indiana University and is board certified in both subspecialties. Recognized as one of "America's Top Doctors for Cancer" in endocrinology, his major clinical and research interests are thyroid cancer, pituitary tumors, and genetic syndromes of endocrine neoplasia. At M. D. Anderson, where he has been on faculty since 2002, Dr. Waguespack enjoys providing endocrine care to patients of all ages.

Research Interests

Thyroid Cancer, Pituitary Disease, Genetic Syndromes of Endocrine Neoplasia, Pediatric Endocrine Tumors

Education & Training

Degree-Granting Education

1994 University of Texas-Houston Medical School, Houston, TX, MD, Medicine
1990 Loyola University, New Orleans, LA, BS, Summa cum laude, Presidential Scholar, Biology

Postgraduate Training

7/1998-6/2002 Fellowship, Adult and Pediatric Endocrinology, Indiana University Medical Center, Indianapolis, IN
7/1994-6/1998 Internship and Residency, Internal Medicine/ Pediatrics, Indiana University Medical Center, Indianapolis, IN

Board Certifications

2003 Pediatric Endocrinology
2002 Endocrinology, Diabetes, and Metabolism
1999 General Pediatrics
1998 Internal Medicine

Selected Publications

Peer-Reviewed Original Research Articles
1. Clayman GL, Shellenberger TD, Ginsberg L, Edeiken B, El-Naggar AK, Sellin RV, Waguespack SG, Roberts DB, Sherman SI, Mirsha A. Approach and Safety of Comprehensive Central Compartment Dissection in Patients with Recurrent Papillary Thyroid Carcinoma. Head Neck 31(9):1152-63, 9/2009. e-Pub 4/2009. PMID: 19360746.
2. Waguespack SG, Williams MD, Clayman GL, Herzog CE. The Successful Use of Sorafenib to Treat Pediatric Papillary Thyroid Carcinoma. Thyroid 19(4):407-12, 4/2009. PMID: 19355831.
3. Jimenez C, Cabanillas ME, Santarpia L, Jonasch E, Kyle KL, Lano EA, Matin SF, Nunez RF, Perrier ND, Phan A, Rich TA, Shah B, Williams MD, Waguespack SG. Use of the Tyrosine Kinase Inhibitor Sunitinib in a Patient with von Hippel-Lindau Disease: Targeting Angiogenic Factors in Pheochromocytoma and other von Hippel-Lindau Disease-related Tumors. J Clin Endocrinol Metab 94(2):386-91, 2/2009. e-Pub 11/2008. PMID: 19017755.
4. Bilen MA, Waguespack SG, Tannir NM, Pravinkumar SE, Tamboli P, Tu SM. Multisystem Crisis in a Patient with Presumptive Renal Cell Carcinoma. Clin Genitourin Cancer 6(2):128-30, 9/2008. PMID: 18824438.
5. Rich TA, Jonasch E, Matin S, Waguespack SG, Gombos DS, Santarpia L, Stolle C, Jimenez C. A Novel von Hippel-Lindau Point Mutation Presents as Apparently Sporadic Pheochromocytoma. Cancer Invest 26(6):642-6, 7/2008. PMID: 18584357.
6. Wray CJ, Rich TA, Waguespack SG, Lee JE, Perrier ND, Evans DB. Failure to recognize multiple endocrine neoplasia 2b: more common than we think? Ann Surg Oncol 15(1):293-301, 1/2008. e-Pub 10/2007. PMID: 17963006.
7. McCutcheon IE, Waguespack SG, Fuller GN, Couldwell WT. Metastatic melanoma to the pituitary gland. Can J Neurol Sci 34(3):322-7, 8/2007. PMID: 17803030.
8. Thompson MA, Habra MA, Routbort MJ, Holsinger FC, Perrier ND, Waguespack SG, Rodriguez MA. Primary adrenal natural killer/T-cell nasal type lymphoma: First case report in adults. Am J Hematol 82(4):299-303, 4/2007. PMID: 17094095.
9. Shaw SA, Camacho LH, McCutcheon IE, Waguespack SG. Transient Hypophysitis after Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA4) Blockade. J Clin Endocrinol Metab 92(4):1201-2, 4/2007. PMID: 17409339.
10. Waguespack SG, Hui SL, Dimeglio LA, Econs MJ. Autosomal Dominant Osteopetrosis: Clinical Severity and Natural History of 94 Subjects with a Chloride Channel 7 Gene Mutation. J Clin Endocrinol Metab 92(3):771-8, 3/2007. e-Pub 12/2006. PMID: 17164308.
11. Kouvaraki MA, Shapiro SE, Cote GJ, Lee JE, Yao JC, Waguespack SG, Gagel RF, Evans DB, Perrier ND. Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. World J Surg 30(5):643-53, 5/2006. PMID: 16680581.
12. Chu K, Koller DL, Snyder R, Fishburn T, Lai D, Waguespack SG, Foroud T, Econs MJ. Analysis of variation in expression of autosomal dominant osteopetrosis type 2: searching for modifier genes. Bone 37(5):655-61, 11/2005. e-Pub 8/2005. PMID: 16120485.
13. Lora MS, Waguespack SG, Moley JF, Walvoord EC. Adrenal ganglioneuromas in children with multiple endocrine neoplasia type 2: a report of two cases. J Clin Endocrinol Metab 90(7):4383-7, 7/2005. e-Pub 4/2005. PMID: 15827098.
14. Habra MA, Feig BW, Waguespack SG. Image in endocrinology: adrenal pseudocyst. J Clin Endocrinol Metab 90(5):3067-8, 5/2005. PMID: 15872337.
15. Cagle AP, Waguespack SG, Buckingham BA, Shankar RR, Dimeglio LA. Severe infantile hypercalcemia associated with Williams syndrome successfully treated with intravenously administered pamidronate. Pediatrics 114(4):1091-5, 10/2004. PMID: 15466114.
16. Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, Asper JA, Diaz EM, Evans DB, Gagel RF, Garden A, Hoff AO, Lee JE, Morrison WH, Rosenthal DI, Sherman SI, Sturgis EM, Waguespack SG, Weber RS, Wirfel K, Vassilopoulou-Sellin R. Parathyroid carcinoma: a 22-year experience. Head Neck 26(8):716-26, 8/2004. PMID: 15287039.
17. Alatalo SL, Ivaska KK, Waguespack SG, Econs MJ, Väänänen HK, Halleen JM. Osteoclast-derived serum tartrate-resistant acid phosphatase 5b in Albers-Schonberg disease (type II autosomal dominant osteopetrosis). Clin Chem 50(5):883-90, 5/2004. e-Pub 3/2004. PMID: 15016726.
18. Yip L, Lee JE, Shapiro SE, Waguespack SG, Sherman SI, Hoff AO, Gagel RF, Arens JF, Evans DB. Surgical management of hereditary pheochromocytoma. J Am Coll Surg 198(4):525-34; discussion 534-5, 4/2004. PMID: 15051000.
19. Alvarado F, Waguespack SG, Campbell JH, Williams TP. Expansile intraosseus lesion of the mandible. J Oral Maxillofac Surg 61(11):1318-23, 11/2003. PMID: 14613089.
20. Riminucci M, Collins MT, Fedarko NS, Cherman N, Corsi A, White KE, Waguespack S, Gupta A, Hannon T, Econs MJ, Bianco P, Gehron Robey P. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J Clin Invest 112(5):683-92, 9/2003. PMCID: PMC182207.
21. Waguespack SG, Koller DL, White KE, Fishburn T, Carn G, Buckwalter KA, Johnson M, Kocisko M, Evans WE, Foroud T, Econs MJ. Chloride channel 7 (ClCN7) gene mutations and autosomal dominant osteopetrosis, type II. J Bone Miner Res 18(8):1513-8, 8/2003. PMID: 12929941.
22. Wilson JL, Sokol DK, Smith LH, Snook RJ, Waguespack SG, Kincaid JC. Acute painful neuropathy (insulin neuritis) in a boy following rapid glycemic control for type 1 diabetes mellitus. J Child Neurol 18(5):365-7, 5/2003. PMID: 12822825.
23. Waguespack SG, Hui SL, White KE, Buckwalter KA, Econs MJ. Measurement of tartrate-resistant acid phosphatase and the brain isoenzyme of creatine kinase accurately diagnoses type II autosomal dominant osteopetrosis but does not identify gene carriers. J Clin Endocrinol Metab 87(5):2212-7, 5/2002. PMID: 11994366.

Invited Articles
1. Ying AK, Huh W, Bottomley S, Evans DB, Waguespack SG. Thyroid cancer in young adults. Semin Oncol 36(3):258-74, 6/2009. PMID: 19460583.
2. Grubbs EG, Rich TA, Li G, Sturgis EM, Younes MN, Myers JN, Edeiken-Monroe B, Fornage BD, Monroe DP, Staerkel GA, Williams MD, Waguespack SG, Hu MI, Cote G, Gagel RF, Cohen J, Weber RS, Anaya DA, Holsinger FC, Perrier ND, Clayman GL, Evans DB. Recent advances in thyroid cancer. Curr Probl Surg 45(3):156-250, 3/2008. PMID: 18346477.

Editorials
1. Waguespack SG. A perspective from pediatric endocrinology on the hereditary medullary thyroid carcinoma syndromes. Thyroid 19(6):543-6, 6/2009. PMID: 19499985.
2. Rich TA, Waguespack SG, Evans DB. Premonitory symptoms preceding metastatic medullary thyroid cancer in multiple endocrine neoplasia type 2B: An exploratory analysis. Surgery 144(6):1052-3, 12/2008. PMID: 19041017.
Other Articles
1. Rich TA, Cabanillas ME, Martin JW, Perrier ND, Waguespack SG. CDC73-Related Disorders [Includes: CDC73-Related Familial Isolated Hyperparathyroidism, Hyperparathyroidism-Jaw Tumor Syndrome, CDC73-Related Parathyroid Carcinoma]. www.genetests.org, 2008.

Abstracts
1. Waguespack SG, Williams MD, Clayman GL, Herzog CE. First successful use of Sorafenib to treat pediatric papillary thyroid carcinoma (PTC). Pediatric Academic Societies Annual Meeting, Toronto Canada, May 5-8, 2007.
2. Athanassaki I, Herzog CE, Smith OE, Haymond MW, Waguespack SG. Interferon-a related thyroid disease in children - a retrospective study. The Endocrine Society's 89th Annual Meeting, Toronto Canada; June 2-5,, 2007.
3. Hu MI, Busaidy NL, Sellin RV, Waguespack SG. Non-Islet cell tumor hypoglycemia and inappropriate cortisol response. The Endocrine Society's 89th Annual Meeting, Toronto Canada, June 2-5, 2007.
4. Yazbeck CF, Gonzalez-Angulo AM, Shaw SA, Waguespack SG, Vassilopoulou-Sellin R, Busaidy NL. Hypocalcemia induced by bisphosphonates in cancer patients with Vitamin D deficiency. The Endocrine Society's 89th Annual Meeting, Toronto Canada; June 2-5, 2007.
5. Shah B, Cote G, Evans D, Waguespack S, Hoff A, Hu M. Sudden Death in a Family with multiple Endocrine Neoplasia type 1 (Men1): An Association of Hypercalcemia with Brugada Syndrome. The Endocrine Society's 90th Annual Meeting, San Francisco, CA, June 15 -18,, 2008.
6. Bharaktiya S, Parikh S, Weber D, Waguespack SG. Sellar Plasmacytoma Mimicking an Invasive Pituitary Macroadenoma-Response to Radiation and Conventional Multiple MyelomaTherapy. the Endocrine Society's 90th Annual Meeting, San Francisco, California June 15,, 2008.
7. Cabanillas ME, Jehaimi C, Waguespack SG. 'Primary Pigmented Nodular Adrenocortical Disease (PPNAD) in a Patient with Carney Complex (CC): A Case Report. American Association of Clinical Endocrinologists 18th Annual Meeting and Clinical Congress, Houston, Texas May 13 - 17,, 2009.
8. Cabanillas ME, Waguespack SG, Bronstein Y, Williams MD, Feng L, Sherman SI, Busaidy NL. Treatment (tx) with tyrosine kinase inhibitors (TKIs) for patients (pts) with differentiated thyroid cancer (DTC): The M. D. Anderson Cancer Center (MDACC) experience. American Society of Clinical Oncology. American Society of Clinical Oncology Annual Meeting, Orlando, Florida, May 29 - June 2,, 2009.
9. Matin S, McCutcheon I, Gombos D, Waguespack S, Wen S, Zhang Y, Davis D, Smith L, Fuller G, Jonasch E. Treatment of VHL patients with sunitinib: clinical observations and translational studies. American Society of Clinical Oncology Annual Meeting, Orlando, Florida, May 29 - June 2,, 2009.
10. Waguespack SG, McCutcheon I, Devin JK, Evans DB, Cote G, Rich T. Apparently Sporadic Pituitary Adenomas Presenting in Children and Young Adults Are Rarely Caused by Mutations in the MEN1 Gene. The Endocrine Society's 91st Annual Meeting, Washington, District of Columbia, June 10-13,, 2009.
11. Cabanillas ME, Kurzrock R, Bidyasar S, Wheler J, Fu S, Naing A, Sherman SI, Gagel R, Waguespack SG, Busaidy N, Sellin R, Hu M, Kies M, Hong DS. Phase 1 trial of combination sorafenib and tipifarnib: update on the experience in advanced differentiated thyroid cancer and medullary thyroid cancer. World Congress on Thyroid Cancer, Toronto, Ontario, Canada, August 6-10,, 2009.
12. Jehaimi C, Waguespack SG. Positron Emission Tomography in the Management of Papillary Thyroid Carcinoma in Children: Is There a Role? LWPES/ESPE 8th Joint Meeting in Pediatric Endocrinology. New York, New York, September 9-12,, 2009.

Book Chapters
1. Waguespack S, Wells SA. Thyroid Carcinoma. In: Cancer in Adolescents and Young Adults. 1. Ed(s) Bleyer A and Barr R. Springer Verlag, 259-68, 2007. PMID: 978-3-540-40842-0.
2. Waguespack S, Wells S, Ross J, Bleyer A. Thyroid Cancer. In: Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000. Ed(s) Bleyer A, O'Leary M, Barr R, Ries LAG. National Cancer Institute, NIH Pub No 06-5767: Bethesda, MD, 143-54, 2006.
3. Waguespack S, Maldonado M, Sekhar R, Gagel R, Balasubramanyam A. Endocrine Evaluation and Management of the Perioperative Cancer Patient. In: Acute Care of the Cancer Patient. Ed(s) Shaw A, Riedel B, Burton A, Fields A, Feeley T. Taylor & Francis: Boca Raton, FL, 43-67, 2005.
4. Waguespack S, Pescovitz OH. Delayed Puberty. In: Developmental Endocrinology: From Research to Clinical Practice. Ed(s) Pescovitz OH and Eugster E. Humana Press: Totowa, NJ, 331-355, 2002.
5. Waguespack S, Walvoord E, Pescovitz OH. Precocious and Delayed Puberty. In: Principles and Practice of Endocrinology and Metabolism, 3rd. Ed(s) Becker KL. Lippincott Williams & Wilkins: Philadelphia, 893-908, 2001.
 

Other
1. Internet article. "Adrenal Manifestations of VHL", 2003.
2. Newsletter article. "How I Manage Thyroid Nodules." Cancer and Blood Disease Newsletter of the Children's Cancer Hospital at MDACC, 2006.
3. Internet article. "Glossary of Pituitary Terminology", Pituitary Tumor Program Website, 2008.
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4. Newsletter Article. "Update in Acromegaly" Department of Endocrine Neoplasia and Hormonal Disorders Newsletter, Spring 2008 (http:/?www.mdanderson.org/pdf/endocrinology-newsletter-vol1-issue1.pdf)
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Last updated: 9/21/2009