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Timothy J. McDonnell, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Deputy Department Chair, Department of Hematopathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1986 Washington University, St. Louis, MO, MD, Medicine
1982 University of North Dakota, Grand Forks, ND, PHD, Anatomy
1980 University of North Dakota, Grand Forks, ND, MS, Anatomy
1977 University of California, La Jolla, CA, BA, Biology
1974 U.S. International University, San Diego, CA, AA, General Academics

Selected Publications

Peer-Reviewed Original Research Articles

1. McDonnell T.J., Troncoso P., Wang X., Bueso-Ramos C.E., Coombes K., Brisbay S., Lopez R., Prendergast G., Cho-Vega J.H., Logothetis C., Do K.A. Variations in biomarker expression pattern that correlate with high grade features in treatment naive, organ-confined prostate cancer. BMC Medical Genomics 1:1-9, 2008.
2. Efstathiou E, Troncoso P, Wen S, Do KA, Pettaway CA, Pisters LL, McDonnell TJ, Logothetis CJ. Initial modulation of the tumor microenvironment accounts for thalidomide activity in prostate cancer. Clin Cancer Res 13:1224-31, 2/2007. PMID: 17317833.
3. Han X, Garcia-Manero G, McDonnell TJ, Lozano G, Medeiros LJ, Xiao L, Rosner G, Nguyen M, Fernandez M, Valentin-Vega YA, Barboza J, Jones DM, Rassidakis GZ, Kantarjian HM, Bueso-Ramos CE. HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target. Mod Pathol 20:54-62, 1/2007. PMID: 17143258.
4. Cho-Vega, J.H., Tsavachidis, S., Do, K-A, Medeiros, L.J., Troncoso, P., Nakagawa, J., McDonnell, T.J. Dicarbonyl/L-xylulose reductase: A new potential biomarker identified by laser capture microdissection-micro serial analysis of gene expression. Cancer Epidemiology, Biomarkers and Prevention 16:2615-2622, 2007.
5. Leroux, M.E., Auzenne, E., Evans, R., Hail, N., Spohn, W., Ghosh, S., Farquhar, D., McDonnell, T., Klostergaard, J. Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce bcl-2-independent apoptosis in human prostatic adenocarcinoma cells. The Prostate 67:1699-1717, 2007.
6. Khor LY, Desilvio M, Li R, McDonnell TJ, Hammond ME, Sause WT, Pilepich MV, Okunieff P, Sandler HM, Pollack A. Bcl-2 and bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10. Int J Radiat Oncol Biol Phys 66:25-30, 9/2006. PMID: 16814949.
7. Spurgers KB, Gold DL, Coombes KR, Bohnenstiehl NL, Mullins B, Meyn RE, Logothetis CJ, McDonnell TJ. Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. J Biol Chem 281:25134-142, 9/2006. PMID: 16798743.
8. Spurgers KB, Chari NS, Bohnenstiehl NL, McDonnell TJ. Molecular mediators of cell death in multistep carcinogenesis: a path to targeted therapy. Cell Death Differ 13(8):1360-70, 8/2006. PMID: 16763617.
9. Wang, J., Do, K.A., Wen, S., Tsavachidou, D., McDonnell, T.J., Logothesis , C.J., Coombes, K.R. Merging microarray data, robust feature selection, and predicting prognosis in prostate cancer. Cancer Informatics 2:87-97, 2006.
10. Broom, B.M., McDonnell, T.J., Subramanian, D. Predicting altered pathways using extendable scaffolds. Int. J. Bionformatics Research and Applications 2:3-18, 2006.
11. Kim J, Sun P, Lam YW, Troncoso P, Sabichi AL, Babaian RJ, Pisters LL, Pettaway CA, Wood CG, Lippman SM, McDonnell TJ, Lieberman R, Logothetis C, Ho SM. Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer. Cancer Epidemiol Biomarkers Prev 14:1697-1702, 7/2005. PMID: 16030104.
12. Bueso-Ramos C, Xu Y, McDonnell TJ, Brisbay S, Pierce S, Kantarjian H, Rosner G, Garcia-Manero G. Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. J Clin Oncol 23:3932-39, 6/2005. PMID: 15851765.
13. Cho-Vega JH, Troncoso P, Do KA, Rago C, Wang X, Tsavachidis S, Medeiros LJ, Spurgers K, Logothetis C, McDonnell TJ. Combined laser capture microdissection and serial analysis of gene expression from human tissue samples. Mod Pathol 18(4):577-84, 4/2005. PMID: 15529182.
14. Bigelow RL, Jen EY, Delehedde M, Chari NS, McDonnell TJ. Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes. J Invest Dermatol 124(2):457-65, 2/2005. PMID: 15675968.
15. Assikis VJ, Do KA, Wen S, Wang X, Cho-Vega JH, Brisbay S, Lopez R, Logothetis CJ, Troncoso P, Papandreou CN, McDonnell TJ. Clinical and biomarker correlates of androgen-independent, locally aggressive prostate cancer with limited metastatic potential. Clin Cancer Res 10:6770-78, 10/2004. PMID: 15501953.
16. Cho-Vega JH, Rassidakis GZ, Admirand JH, Oyarzo M, Ramalingam P, Paraguya A, McDonnell TJ, Amin HM, Medeiros LJ. MCL-1 expression in B-cell non-Hodgkin's lymphomas. Hum Pathol 35:1095-1100, 9/2004. PMID: 15343511.
17. Resetkova E, Gonzalez-Angulo AM, Sneige N, McDonnell TJ, Buzdar AU, Kau SW, Yamamura Y, Reuben JM, Hortobagyi GN, Cristofanilli M. Prognostic value of P53, MDM-2, and MUC-1 for patients with inflammatory breast carcinoma. Cancer 101:913-17, 9/2004. PMID: 15329897.
18. Amin HM, McDonnell TJ, Ma Y, Lin Q, Fujio Y, Kunisada K, Leventaki V, Das P, Rassidakis GZ, Cutler C, Medeiros LJ, Lai R. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene 23(32):5426-34, 7/2004. PMID: 15184887.
19. Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10(6):594-601, 6/2004. PMID: 15156201.
20. Rosser CJ, Tanaka M, Pisters LL, Tanaka N, Levy LB, Hoover DC, Grossman HB, McDonnell TJ, Kuban DA, Meyn RE. Adenoviral-mediated PTEN transgene expression sensitizes Bcl-2-expressing prostate cancer cells to radiation. Cancer Gene Ther 11:273-79, 4/2004. PMID: 14765130.
21. Pisters LL, Pettaway CA, Troncoso P, McDonnell TJ, Stephens LC, Wood CG, Do KA, Brisbay SM, Wang X, Hossan EA, Evans RB, Soto C, Jacobson MG, Parker K, Merritt JA, Steiner MS, Logothetis CJ. Evidence that transfer of functional p53 protein results in increased apoptosis in prostate cancer. Clin Cancer Res 10(8):2587-93, 4/2004. PMID: 15102659.
22. Honda T, Coppola S, Ghibelli L, Cho SH, Kagawa S, Spurgers KB, Brisbay SM, Roth JA, Meyn RE, Fang B, McDonnell TJ. GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells. Cancer Gene Ther 11(4):249-55, 4/2004. PMID: 15002033.
23. Spurgers KB, Coombes KR, Meyn RE, Gold DL, Logothetis CJ, Johnson TJ, McDonnell TJ. A comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells. Oncogene 23(9):1712-23, 3/2004. PMID: 14647426.
24. Nam DH, Park K, Park C, Im YH, Kim MH, Lee S, Hong SC, Shin HJ, Kim JH, Eoh W, McDonnell TJ. Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib. Oncol Rep 11:263-68, 2/2004. PMID: 14719052.
25. Bigelow RL, Chari NS, Unden AB, Spurgers KB, Lee S, Roop DR, Toftgard R, McDonnell TJ. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem 279:1197-1205, 1/2004. PMID: 14555646.
26. Drakos E, Rassidakis GZ, Lai R, Herling M, O'Connor SL, Schmitt-Graeff A, McDonnell TJ, Medeiros LJ. Caspase-3 activation in systemic anaplastic large-cell lymphoma. Mod Pathol 17(1):109-16, 2004. PMID: 14657946.
27. Amin HM, Medeiros LJ, Ma Y, Feretzaki M, Das P, Leventaki V, Rassidakis GZ, O'Connor SL, McDonnell TJ, Lai R. Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. Oncogene 22(35):5399-407, 8/2003. PMID: 12934099.
28. Rassidakis GZ, Jones D, Lai R, Ramalingam P, Sarris AH, McDonnell TJ, Medeiros LJ. BCL-2 family proteins in peripheral T-cell lymphomas: correlation with tumour apoptosis and proliferation. J Pathol 200:240-48, 6/2003. PMID: 12754745.
29. Sah NK, Munshi A, Kurland JF, McDonnell TJ, Su B, Meyn RE. Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase. J Biol Chem 278(23):20593-602, 6/2003. PMID: 12663665.
30. Amin HM, McDonnell TJ, Medeiros LJ, Rassidakis GZ, Leventaki V, O'Connor SL, Keating MJ, Lai R. Characterization of 4 mantle cell lymphoma cell lines. Arch Pathol Lab Med 127(4):424-31, 4/2003. PMID: 12683869.
31. Bruckheimer EM, Spurgers K, Weigel NL, Logothetis C, McDonnell TJ. Regulation of Bcl-2 expression by dihydrotestosterone in hormone sensitive LNCaP-FGC prostate cancer cells. J Urol 169:1553-57, 4/2003. PMID: 12629413.
32. Aranha O, Grignon R, Fernandes N, McDonnell TJ, Wood DP, Jr, Sarkar FH. Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis. Int J Oncol 22(4):787-94, 4/2003. PMID: 12632069.
33. Milas I, Komaki R, Hachiya T, Bubb RS, Ro JY, Langford L, Sawaya R, Putnam JB, Allen P, Cox JD, McDonnell TJ, Brock W, Hong WK, Roth JA, Milas L. Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. Clin Cancer Res 9:1070-76, 3/2003. PMID: 12631609.
34. Rassidakis GZ, Claret FX, Lai R, Zhang Q, Sarris AH, McDonnell TJ, Medeiros LJ. Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma. Clin Cancer Res 9:1121-28, 3/2003. PMID: 12631617.
35. Khoury JD, Medeiros LJ, Rassidakis GZ, McDonnell TJ, Abruzzo LV, Lai R. Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression. J Pathol 199:90-97, 2003. PMID: 12474231.
36. Lai R, Rassidakis GZ, Medeiros LJ, Leventaki V, Keating M, McDonnell TJ. Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours. J Pathol 199(1):84-9, 2003. PMID: 12474230.
37. DuHadaway, Lynch, FJ, Brisbay, S, Bueso-Ramos, C, Troncoso, P, McDonnell, T, Prendergast, GC. Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: diverse sites of nuclear expression and losses in prostate cancer. . J. Cell. Biochem. 88:635-642, 2003.
38. Tsao, McDonnell, T, Lam, S, Putnam, JB, Bekele, N, Hong, WK, Kurie, J. Increased phospho-AKT (Ser(473)) expression in bronchial dysplasia: Implications for lung cancer prevention studies. . Cancer Epidemiology, Biomarkers & Prevention 12:660-664, 2003.
39. Swisher, Roth, JA, Komaki, R, Gu, J, Lee, JJ, Hicks, M, Ro, J, Hong, WK, Merritt, JA, Ahrar, K, Atkinson, N, Correa, AM, Dolormente, M, Dreiling, L, El-Naggar, AK, Fossella, F, Francisco, R, Glisson, B, Grammer, S, Herbst, R, Huaringa, A, Kemp, B, Khuri, FR, Kurie, JM, Liao, Z, McDonnell, TJ, Morice, R, Morello, F, Munden, R, Papadimitrakoopoulou, V, Pisters, KM, Putnam, JB, Sarabia, AJ, Shelton, T, Stephens, C, Shin, DM, Smythe, WR, Vaporciyan, A, Walsh, GL, Yin, M. Induction of p53 regulated genes and tumor regression in lung cancer patients following intratumoral delivery of adenoviral p53 (RPR/INGN 201) and radiation therapy. . Clin. Cancer Res. 9:93-101, 2003.
40. Pollack, Cowen, D, Troncoso, P, Zagars, GK, von Eschenbach, AC, Meistrich, ML, McDonnell, T. Molecular markers of patient outcome in prostate cancer treated with radiotherapy: Ki-67, bcl-2, bax, bcl-x . . Cancer 97:1630-1638, 2003.
41. Coombes KR, Zhang L, Bueso-Ramos C, Brisbay S, Logothetis C, Roth J, Keating MJ, McDonnell TJ. TAD: a web interface and database for tissue microarrays. Appl Bioinformatics 1:155-58, 2002. PMID: 15130842.

Invited Articles

1. Chari NS, Pinaire NL, Thorpe L, Medeiros LJ, Routbort MJ, McDonnell TJ. The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death. Apoptosis 14(4):336-47, 4/2009. e-Pub 2/2009. PMID: 19229632.
2. Chari, N.S., McDonnell, T.J. The sonic hedgehog signaling network in prostate development and neoplasia. Adv. Anat. Pathol. 14:344-352, 2007.

Last updated: 10/22/2012