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Uwe Titt, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Radiation Physics - Patient Care, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street
Unit Number: 1420
Houston, TX 77030-3722
Phone: (713) 563-2558
Fax: (713) 563-2545
Email: utitt@mdanderson.org

Education & Training

Degree-Granting Education

1994 Johann Wolfgang Goethe Universitat, Frankfurt, Germany, Diploma examination, Nuclear Physics
1994 Johann Wolfgang Goethe Universität, Frankfurt, Germany, PHD, Nuclear Physics
1991 Johann Wolfgang Goethe Universitat, Frankfurt, Germany, Pre-examination Diploma, Pre-examination

Postgraduate Training

1999-2000 Post Doctoral Fellow, Neutron Dosimetry, Massachusetts General Hospital, Boston, MA

Experience/Service

Academic Appointments

Assistant Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2003-8/2010
Instructor, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, 9/2000-7/2003
Teaching Assistant, Bio-Chemistry, Technische Universität, Braunschweig, Germany, 8/1997-9/1999
Instructor, Bio-Chemistry, Technische Universität, Braunschweig, Germany, 8/1997-9/1999
Instructor, Nuclear Physics, Johann Wolfgang Goethe Universität, Frankfurt, Frankfurt, Germany, 7/1993-9/1994

Other Appointments/Responsibilities

Staff Scientist, Biochemistry, Technische Universität, Braunschweig, Germany, 1997-1999
Nuclear Physicist, Weizmann Institute of Science Rehovot, Rehovot, Israel, 1994-1995

Honors and Awards

1999 Helmholtz Prize, Physikalisch Technische Bundesanstalt, Braunschweig, Germany

Selected Publications

Peer-Reviewed Original Research Articles

1. Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Sci Rep 5:9850, 2015. e-Pub 5/18/2015. PMID: 25984967.
2. Sawakuchi GO, Sahoo GP, Gasparian P, Rodriguez M, Archambault L, Titt U, Yukihara E. Determination of average LET of therapeutic proton beams using A1203:C optically stimulated luminescence (OSL) detectors. Phys Med Biol 55(17):3239-3240, 5/2014.
3. Perles LA, Mirkovic D, Anand A, Titt U, Mohan R. LET dependence of the response of EBT2 films in proton dosimetry modeled as a bimolecular chemical reaction. Phys Med Biol 58(23):8477-91, 12/7/2013. e-Pub 11/15/2013. PMID: 24240474.
4. Newhauser WD, Rechner L, Mirkovic D, Yepes P, Koch NC, Titt U, Fontenot JD, Zhang R. Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams. Radiat Meas 58:37-44, 11/1/2013. e-Pub 8/2013. PMCID: PMC4136527.
5. Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Titt U, Paganetti H, Kerr M, Mawlawi O. Feasibility of proton-activated implantable markers for proton range verification using PET. Phys Med Biol 58(21):7497-7512, 11/7/2013. e-Pub 10/8/2013. PMCID: PMC3998106.
6. Zhu XR, Poenisch F, Lii M, Sawakuchi GO, Titt U, Bues M, Song X, Zhang X, Li Y, Ciangaru G, Li H, Taylor MB, Suzuki K, Mohan R, Gillin MT, Sahoo N. Commissioning dose computation models for spot scanning proton beams in water for a commercially available treatment planning system. Med Phys 40(4):041723, 4/2013. PMCID: PMC3631269.
7. Titt U, Bednarz B, Paganetti H. Comparison of MCNPX and Geant4 proton energy deposition predictions for clinical use. Phys Med Biol 57(20):6381-93, 10/21/2012. e-Pub 9/21/2012. PMCID: PMC3496257.
8. Yang M, Zhu XR, Park PC, Titt U, Mohan R, Virshup G, Clayton JE, Dong L. Comprehensive analysis of proton range uncertainties related to patient stopping-power-ratio estimation using the stoichiometric calibration. Phys Med Biol 57(13):4095-115, 7/7/2012. e-Pub 6/7/2012. PMCID: PMC3396587.
9. Peeler CR, Titt U. Monte Carlo study of radial energy deposition from primary and secondary particles for narrow and large proton beamlet source models. Phys Med Biol 57((12)):3785-92, 6/21/2012. e-Pub 5/23/2012. PMCID: PMC3380359.
10. Anand A, Sahoo N, Zhu XR, Sawakuchi GO, Poenisch F, Amos RA, Ciangaru G, Titt U, Suzuki K, Mohan R, Gillin MT. A procedure to determine the planar integral spot dose values of proton pencil beam spots. Med Phys 39((2)):39(2):891-900, 2/2012. PMCID: PMC3277608.
11. Titt U, Mirkovic D, Sawakuchi GO, Perles LA, Newhauser WD, Taddei PJ, Mohan R. Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency. Phys Med Biol 55((23)):7097-106, 12/7/2010. e-Pub 11/12/2010. PMCID: PMC3001334.
12. Yepes PP, Brannan T, Huang J, Mirkovic D, Newhauser WD, Taddei PJ, Titt U. Application of a fast proton dose calculation algorithm to a thorax geometry. Radiat Meas 45(10):1367-1368, 12/1/2010. PMCID: PMC3085469.
13. Fontenot JD, Bloch C, Followill D, Titt U, Newhauser WD. Estimate of the uncertainties in the relative risk of secondary malignant neoplasms following proton therapy and intensity-modulated photon therapy. Phys Med Biol 55(23):6987 - 6998, 11/2010.
14. Sawakuchi GO, Mirkovic D, Perles LA, Sahoo N, Zhu XR, Ciangaru G, Suzuki K, Gillin MT, Mohan R, Titt U. An MCNPX Monte Carlo Model of a Discrete Spot Scanning Proton Beam Therapy Nozzle. Med Phys 37(9):4960-4970, 9/2010. PMCID: PMC2941520.
15. Perles L, Mirkovic D, Sawakuchi G, Titt U. Monte Carlo Investigation of Rebinning Material Density Distributions of Lung Parenchyma Phantoms in Proton Therapy. Nuclear Technology 175:22-26, 7/2010.
16. Sawakuchi GO, Zhu XR, Poenisch F, Suzuki K, Ciangaru G, Titt U, Anand A, Mohan R, Gillin MT, Sahoo N. Experimental characterization of the low-dose envelope of spot scanning proton beams. Phys Med Biol 55(12):3467-78, 6/2010. e-Pub 5/2010. PMID: 20508318.
17. Sawakuchi GO, Titt U, Mirkovic D, Ciangaru G, Zhu XR, Sahoo N, Gillin MT, Mohan R. Monte Carlo investigation of the low-dose envelope from scanned proton pencil beams. Phys Med Biol 55(3):711-721, 2/2010. e-Pub 1/2010. PMID: 20071752.
18. Gillin MT, Sahoo N, Bues M, Ciangaru G, Sawakuchi G, Poenisch F, Arjomandy B, Martin C, Titt U, Suzuki K, Smith AR, Zhu XR. Commissioning of the discrete spot scanning proton beam delivery system at The University of Texas M.D. Anderson Cancer Center, Proton Therapy Center, Houston. Med Phys 37(1):154-163, 1/2010. PMID: 20175477.
19. Yukihara EG, Gasparian PBR, Sawakuchi GO, Ruan C, Ahmad S, Kalavangunta C, Clouse WJ, Sahoo N and Titt U. Medical applications of optically stimulated luminescence dosimeters (OSLD's). Radiat Meas 45(3-6):658–662, 2010.
20. Taddei PJ, Mirkovic D, Fontenot JD, Giebeler A, Zheng Y, Titt U, Woo S, Newhauser WD. REDUCING STRAY RADIATION DOSE FOR A PEDIATRIC PATIENT RECEIVING PROTON CRANIOSPINAL IRRADIATION. Nucl Technol 168(1):108-112, 10/1/2009. PMCID: PMC2943394.
21. Kry SF, Salehpour M, Titt U, White RA, Stovall M, Followill D. Monte Carlo study shows no significant difference in second cancer risk between 6- and 18-MV intensity-modulated radiation therapy. Radiother Oncol 91(1):132-7, 4/2009. e-Pub 1/2009. PMID: 19147246.
22. Vassiliev ON, Kry SF, Chang JY, Balter PA, Titt U, Mohan R. Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac. J Appl Clin Med Phys 10(1):2880, 2009. e-Pub 1/2009. PMID: 19223837.
23. Vassiliev ON, Wareing TA, Davis IM, McGhee J, Barnett D, Horton JL, Gifford K, Failla G, Titt U, Mourtada F. Feasibility of a multigroup deterministic solution method for three-dimensional radiotherapy dose calculations. Int J Radiat Oncol Biol Phys 72(1):220-7, 9/1/2008. PMCID: PMC2597668.
24. Sawakuchi GO, Titt U, Mirkovic D, Mohan R. Density heterogeneities and the influence of multiple Coulomb and nuclear scatterings on the Bragg peak distal edge of proton therapy beams. Phys Med Biol 53(17):4605-19, 9/2008. e-Pub 8/2008. PMID: 18678928.
25. Titt U, Sahoo N, Ding X, Zheng Y, Newhauser WD, Zhu XR, Polf JC, Gillin MT, Mohan R. Assessment of the accuracy of an MCNPX-based Monte Carlo simulation model for predicting three-dimensional absorbed dose distributions. Phys Med Biol 53(16):4455-70, 8/2008. e-Pub 7/2008. PMID: 18670050.
26. Kry SF, Howell RM, Titt U, Salehpour M, Mohan R, Vassiliev ON. Energy spectra, sources, and shielding considerations for neutrons generated by a flattening filter-free Clinac. Med Phys 35(5):1906-11, 5/2008. PMID: 18561666.
27. Taddei PJ, Fontenot JD, Zheng Y, Mirkovic D, Lee AK, Titt U, Newhauser WD. Reducing stray radiation dose to patients receiving passively scattered proton radiotherapy for prostate cancer. Phys Med Biol 53(8):2131-47, 4/21/2008. e-Pub 3/27/2008. PMCID: PMC4144020.
28. Koch N, Newhauser WD, Titt U, Gombos D, Coombes K, Starkschall G. Monte Carlo calculations and measurements of absorbed dose per monitor unit for the treatment of uveal melanoma with proton therapy. Phys Med Biol 53(6):1581-94, 3/21/2008. e-Pub 2/25/2008. PMCID: PMC4101899.
29. Titt U, Zheng Y, Vassiliev ON, Newhauser WD. Monte Carlo investigation of collimator scatter of proton-therapy beams produced using the passive scattering method. Phys Med Biol 53(2):487-504, 1/2008. e-Pub 12/2007. PMID: 18185001.
30. Polf JC, Harvey MC, Titt U, Newhauser WD, Smith AR. Initial beam size study for passive scatter proton therapy. I. Monte Carlo verification. Med Phys 34(11):4213-8, 11/2007. PMID: 18072485.
31. Kry SF, Titt U, Followill D, Pönisch F, Vassiliev ON, White RA, Stovall M, Salehpour M. A Monte Carlo model for out-of-field dose calculation from high-energy photon therapy. Med Phys 34(9):3489-99, 9/2007. PMID: 17926952.
32. Newhauser W, Fontenot J, Zheng Y, Polf J, Titt U, Koch N, Zhang X, Mohan R. Monte Carlo simulations for configuring and testing an analytical proton dose-calculation algorithm. Phys Med Biol 52(15):4569-4584, 8/2007. e-Pub 7/2007. PMID: 17634651.
33. Vassiliev ON, Kry SF, Kuban DA, Salehpour M, Mohan R, Titt U. Treatment-Planning Study of Prostate Cancer Intensity-Modulated Radiotherapy with a Varian Clinic Operated without a Flattening Filter. Int J Radiat Oncol Biol Phys 68(5)(5):1567-1571, 8/2007. e-Pub 6/2007. PMID: 17544596.
34. Kry SF, Titt U, Pönisch F, Vassiliev ON, Salehpour M, Gillin M, Mohan R. Reduced neutron production through use of a flattening-filter-free accelerator. Int J Radiat Oncol Biol Phys 68(4)(4):1260-1264, 7/2007. PMID: 17637397.
35. Fontenot JD, Newhauser WD, Bloch C, White RA, Titt U, Starkschall G. Determination of output factors for small proton therapy fields. Med Phys 34(2):489-498, 2/2007. PMID: 17388166.
36. Vassiliev ON, Titt U, Kry SF, Mohan R, Gillin MT. Radiation safety survey on a flattening filter-free medical accelerator. Radiat Prot Dosimetry 124(2):187-90, 2007. e-Pub 8/2007. PMID: 17681966.
37. Kry SF, Titt U, Pönisch F, Followill D, Vassiliev ON, White RA, Mohan R, Salehpour M. A Monte Carlo model for calculating out-of-field dose from a varian 6 MV beam. Med Phys 33(11):4405-4413, 11/2006. PMID: 17153419.
38. Titt U, Vassiliev ON, Ponisch F, Dong L, Liu H, Mohan R. A flattening filter free photon treatment concept evaluation with Monte Carlo. Med Phys 33(6):1595-1602, 6/2006. PMID: 16872067.
39. Pönisch F, Titt U, Vassiliev ON, Kry SF, Mohan R. Properties of unflattened photon beams shaped by a multileaf collimator. Med Phys 33(6):1738-46, 6/2006. PMID: 16872081.
40. Vassiliev ON, Titt U, Pönisch F, Kry SF, Mohan R, Gillin MT. Dosimetric properties of photon beams from a flattening filter free clinical accelerator. Phys Med Biol 51(7):1907-1917, 4/2006. e-Pub 3/2006. PMID: 16552113.
41. Vassiliev ON, Titt U, Kry SF, Pönisch F, Gillin MT, Mohan R. Monte Carlo study of photon fields from a flattening filter-free clinical accelerator. Med Phys 33(4):820-827, 4/2006. PMID: 16696457.
42. Pönisch F, Titt U, Kry SF, Vassiliev ON, Mohan R. MCNPX simulation of a multileaf collimator. Med Phys 33(2):402-404, 2/2006. PMID: 16532947.
43. Titt U, Vassiliev ON, Ponisch F, Kry SF, Mohan R. Monte Carlo study of backscatter in a flattening filter free clinical accelerator. Med Phys 33(9):3270-3273, 2006. PMID: 17022221.
44. Newhauser W, Koch N, Hummel S, Ziegler M, Titt U. Monte Carlo simulations of a nozzle for the treatment of ocular tumours with high-energy proton beams. Phys Med Biol 50(22):5229-5249, 11/2005. e-Pub 10/2005. PMID: 16264250.
45. Newhauser WD, Ding X, Giragosian D, Nill S, Titt U. A Neutron radiation area monitoring system for proton therapy facilities. Radiat Prot Dosimetry 115(1-4):149-153, 2005. PMID: 16381703.
46. Titt U, Newhauser WD. Neutron shielding calculations in a proton therapy facility based on Monte Carlo simulations and analytical models: criterion for selecting the method of choice. Radiat Prot Dosimetry 115(1-4):144-148, 2005. PMID: 16381702.
47. Polf JC, Newhauser WD, Titt U. Patient neutron dose equivalent exposures outside of the proton therapy treatment field. Radiat Prot Dosimetry 115(1-4):154-158, 2005. PMID: 16381704.
48. Bues M, Newhauser WD, Titt U, Smith AR. Therapeutic step and shoot proton beam spot-scanning with a multi-leaf collimator: a Monte Carlo study. Radiat Prot Dosimetry 115(1-4):164-169, 2005. PMID: 16381706.
49. Fontenot JD, Newhauser WD, Titt U. Design tools for proton therapy nozzles based on the double-scattering foil technique. Radiat Prot Dosimetry 31(1-4 Pt 2):1723, 2004. PMID: 16604629.
50. Titt U, Dangendorf V, Grobwendt V, Schuhmacher H. Development and Application of an Optical TPC for Charged Particle Track Structure Imaging in Microdosimetry. Nuclear Instruments and Methods A477:536-539, 2002.
51. Dangendorf V, Schuhmacher H, Titt U, Tittelmeier K. Imaging of microscopic features of charged particle tracks in a low-pressure gas. Radiat Prot Dosimetry 99:353-354, 2002. PMID: 12194322.
52. Yan X, Newhauser WD, Titt U, Koehler AM. Measurement of neutron dose equivalent to proton therapy patients outside of the proton radiation field. Nuclear Instruments and Methods A476:429-434, 2002.
53. Newhauser WD, Titt U, Dexheimer D, Yan X, Nill S. Neutron shielding verification measurements and simulations for a 235-MeV Proton Therapy Center. Nuclear Instruments and Methods A476:80-84, 2002.
54. Titt U, Dangendorf V, Schuhmacher H. Digital imaging of charged particle track structures with a low pressure optical time projection chamber. Nucl Phys B (Pro Suppl) 78:444-448, 1999.
55. Titt U, Breskin A, Checkhik R, Dangendorf V, Schmidt-Bocking H, Schuhmacher H. A time projection chamber with optical read out for charged particle track sturcture imaging. Nucl Instr & Meth A416:85-89, 1998.
56. Titt U, Breskin A, Chechik R, Dangendorf V, Grobwendt B, Schuhmacher H. Concept of a neutron dosimeter based on a recoil particle track chamber. Radiat Prot Dosim 70:219-224, 1997.
57. Guan F, Peeler C, Bronk L, Taleei R, Randeniya S, Ge S, Mirkovich D, Grosshans D, Mohan R, Titt U. Analysis of the Track and Dose Averaged LET and LET Spectra in Proton Therapy using the Geant4 Monte Carlo Code. Med Phys. Submitted.
58. Titt U, Sell M, Unkelbach J, Bangert M, Mirkovic D, Oelfke U, Mohan R. Degradation of Proton Dose Distributions Attributable to Microstructures in Lung-equivalent Material. Med Phys. Submitted.
59. Taleei R, Guan F, Peeler C, Bronk L, Mirkovic D, Grosshans D, Mohan R, Titt U. Monte Carlo study (prediction) of helium ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Med Phys. Submitted.

Abstracts

1. Cao W, Zaghian M, Randeniya K, Lim G, Titt U, Mohan R. An Investigation of Including Variable Relative Biological Effectiveness in Intensity Modulated Proton Therapy Planning Optimization for Head and Neck Cancer Patients. Med Phys 42(6):3356, 6/2015. PMID: 26127776.
2. Guan F, Titt U, Patel D, Bronk L, Taleei R, Peeler C, Mirkovic D, Grosshans D, Jakel O, Mohan R. Experimental Design for High-Throughput In-Vitro RBE Measurements Using Protons, Helium and Carbon Ions. Med Phys 42(6):3675, 6/2015. PMID: 26129285.
3. Taleei R, Peeler C, Guan F, Patel D, Titt U, Mirkovic D, Grosshans D, Mohan R. Modeling Biological Response to Proton Irradiation and Evaluating Its Potential Clinical Consequences. Med Phys 42(6):3461, 6/2015. PMID: 26128210.
4. Mirkovic D, Peeler C, Grosshans D, Titt U, Taleei R, Mohan R. Modeling Relative Biological Effectiveness of Protons for Radiation Induced Brain Necrosis. Med Phys 42(6):3461, 6/2015. PMID: 26128212.
5. Guan F, Bronk L, Kerr M, Titt U, Wang X, Taleei R, Peeler C, Patel D, Mirkovic D, Grosshans D, Mohan R. Quantifying the Biological Effects of Therapeutic Protons by LET Spectrum Analysis. Med Phys 42(6):3616, 6/2015. PMID: 26128964.
6. Peeler C, Taleei R, Guan F, Bronk L, Patel D, Titt U, Mirkovic D, Stewart R, Grosshans D, Mohan R. Relative Biological Effectiveness of Double-Strand Break Induction for Modeling Cell Survival in Pristine Proton Beams of Different Dose-Averaged Linear Energy Transfers. Med Phys 42(6):3529, 6/2015. PMID: 26128495.
7. Titt U, Suzuki K. Validation of the MCNPX Monte Carlo Model of the Ocular Beam Line at the Proton Therapy Center Houston. Med Phys 42(6):3520, 6/2015. PMID: 26128458.
8. Cao W, *Zaghian M, Randeniya K, Lim G, Titt U, Mohan R. An Investigation of Including Variable Relative Biological Effectiveness in Intensity Modulated Proton Therapy Planning Optimization for Head and Neck Cancer Patients. AAPM 2015, Anaheim, CA, 2015.
9. Guan F, Titt U, Patel D, Bronk L, Taleei R, Peeler C, Mirkovic D, Grosshans D, Jakel O, Mohan R. Experimental Design for High-Throughput In-Vitro RBE Measurements Using Protons, Helium and Carbon Ions. AAPM 2015, Anaheim, CA, 2015.
10. Titt U, Bronk L, Patel D, Guan F, Taleei R, Grosshans D, Brons S, Bangert M, Jakel O, Mohan R. High throughput, high accuracy cell survival experiments with proton, helium, and carbon beams. PTCOG 54, San Diego, CA, 2015.
11. Taleei R, Peeler C, Guan F, Patel D, Titt U, Mirkovic D, Stewart R, Grosshans D, Mohan R. Modeling Biological Response to Proton Irradiation and Evaluating Its Potential Clinical Consequences. AAPM 2015, Aneheim, CA, 2015.
12. Mirkovic D, Peeler C, Grosshans D, Titt U, Taleei R, Mohan R. Modeling Relative Biological Effectiveness of Protons for Radiation Induced Brain Necrosis. AAPM 2015, Anaheim, CA, 2015.
13. Guan F, Bronk L, Kerr, M, Titt U, Wang X, Taleei R, Peeler C, Patel D, Mirkovic D, Grosshans D, Mohan R. Quantifying the Biological Effects of Therapeutic Protons by LET Spectrum Analysis. AAPM 2015, Anaheim, CA, 2015.
14. Peeler C, Taleei R, Guan F, Bronk L, Patel D, Titt U, Mirkovic D, Stewart R, Grosshans D, Mohan R. Relative Biological Effectiveness of Double-Strand Break Induction for Modeling Cell Survival in Pristine Proton Beams of Different Dose-Averaged Linear Energy Transfers. AAPM 2015, Anaheim, CA, 2015.
15. Titt U, Suzuki K. Validation of the MCNPX Monte Carlo Model of the Ocular Beam Line at the Proton Therapy Center Houston. AAPM 2015, Anaheim, CA, 2015.
16. Titt U, Mirkovic D, Liu AY, Anand A, Perles LA, Ciangaru G, Mohan R. Commissioning of the MC² Monte Carlo Dose Computation Engine. PTCOG-53 June 2014, Shanghai, China, 6/2014.
17. Peeler C, Guan F, Bronk L, Grosshans D, Mirkovic D, Titt U, Mohan R. Application of the Repair-Misrepair-Fixation RBE Model to Describe the Results of High Resolution Proton Irradiation Cell Survival Experiments. AAPM 2014, Austin, Texas, 2014.
18. Titt U, Mirkovic D, Liu AY, Anand A, Perles LA, Ciangaru G, Mohan R. Commissioning of the MC² Monte Carlo Dose Computation Engine. AAPM 2014, Austin, Texas, 2014.
19. Mirkovic D, Yepoes P, Titt U, MOhan R. Fast Four Dimensional Monte Carlo Dose Computations for Proton Therapy of Lung Cancer. AAPM 2014, Austin, Texas, 2014.
20. Bronk L, Guan F, Kerr M, Dingh J, Titt U, Mirkovic D, Lin S, Mohan R. High Throughput Mapping of Proton Biologic Effect. AAPM 2014, Austin, Texas, 2014.
21. Randeniya S, Mirkovic D, Titt U, Guan F, Mohan R. Importance of Energy Dependent Protons per MU Calibration Factors in IMPT Dose Calculations Using Monte Carlo Technique. AAPM 2014, Austin, Texas, 2014.
22. Taleei R, Titt U, Peeler C, Mirkovic D, Grosshans D, Mohan R. Modeling Physics Properties and Biologic Effects Induced by Protons. AAPM 2014, Austin, Texas, 2014.
23. Guan F, Titt U, Taleei R, Bangert M, Mirkovic D, Zhu XR, Carlson D, Grosshans D, Mohan R. Monte Carlo Analysis of the Dose Contributions from Primary and Secondary Particles in Light-Ion Therapy. PTCOG-53 June 2014, Shanghai, China, 2014.
24. Guan F, Bronk L, Kerr M, Titt U, Taleei R, Mikovic D, Zhu X, Grosshans D, Mohan R. The Effect of Particle Tracking Step Size Limit on Monte Carlo Computed LET Spectrum of Therapeutic Proton Beams. AAPM 2014, Austin, Texas, 2014.
25. Mohan R, Guan F, Dihn J, Kerr M, Mirkovic D, Titt U, Zhu XR, Gillin MT, Meyn R, Lin S. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE. PTCOG-52 June 2013, Essen, Germany, 6/2013.
26. TItt U, Mirkovic D, Liu AY, Mohan R,. Automated Monte Carlo Simulations of Proton Treatmen Plans. PTCOG-52, Essen Germany, June 2013, 2013.
27. Peeler C, Mirkovic D, Perles L, Titt U, Grosshans D, Mohan R. Comparison of Results for RBE-Weighted Dose from Two RBE Models for Proton Therapy Plans. AAPM 2013, Indianapolis, Indiana, 2013.
28. Mohan R, Guan F, Dihn J, Kerr M, Mirkovic D, Titt U, Zhu XR, Gillin MT, Meyn R, Lin S, Grosshand D. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE. AAPM 2013, Indianapolis, Indiana, 2013.
29. Guan F, Titt U, Bangert M, Mohan R. In Search of the Optimum Ion for Radiotherapy. AAPM 2013, Indianapolis, Indiana, 2013.
30. Poenisch F, Kerr M,Zhu XR, Sahoo N, Dhanesar S, Titt U, Suzuki K, Mohan R, Gillin MT. Measurement of the Effect of Apertures in Proton Scanning Beam. PTCOG-52, Essen, Germany June 2013, 2013.
31. Perles LA, Titt U, Mirkovic D, Mohan R. Modeling the Cell Inactivation Process for High LET Particles by Using the Law of Mass Action. AAPM 2013, Indianapolis, Indiana, 2013.
32. Titt U, Guan F, Mirkovic D, Mohan R,. On the Out-of-Field-Doses Caused by Secondard Particles from Light Ion Beams in Charged Particle Therapy. AAPM 2013, Indianapolis, Indiana, 2013.
33. Howell R, Kry S, Titt U. Project Based Learning - Expanding Course Content with a Broad-Scope Project. AAPM 2013, Indianapolis, Indiana, 2013.
34. Cho J, Ibbott G, Gillin M, Gonzales-Iepera, Titt U, Mawlawi O. Proton Beam Range Verification Using Proton Activated Fiducials and Off-Site PET. AAPM 2013, Indianapolis, Indiana, 2013.
35. Titt U, Liu AY, Mirkovic D. Runtime Optimization for the Automatic Monte Carlo Dose Computation System MC2. AAPM 2013, Indianapolis, IN, 2013.
36. Titt U, Mirkovic D. Mohan R. Three-Dimensional Energy Fluence Estimates for Future Treatment Planning Systems. AAPM 2013, Indianapolis, Indiana, 2013.
37. Mirkovic D, Titt U, Peeler C, Perles L, Liao Z, Mohan R. Variable RBE and Incidence of Radiation Pneumonitis in Lung Patients Treated with Proton Therapy. AAPM 2013, Indianapolis, Indiana, 2013.
38. Titt U, Mirkovic D, Liu A, Mohan R. Automatic Monte Carlo Dose Calculations of Proton Treatment Plans. AAPM 2012, Charlotte, North Carolina, 2012.
39. Bangert M, Titt U, Ziegenhein P, Mohan R, Oelkfe U. Beam Angle Optimization for IMPT Comparing Gantries and Fixed Beam Lines. AAPM 2012, Charoltte, North Carolina, 2012.
40. Peeler C, Mirkovic C, Grosshans D, Titt U Mohan R. Correlating Areas of Radiation Toxicity with Relative Biological Effectiveness-Weighted Dose Distributions in Proton Radiotherapy. AAPM 2012, Charolotte, North Carolina, 2012.
41. Perles L, Mirkovic D, Annand A, Titt U, Mohan R. Dose Response of EBT2 Film Modeled as a Biomelecular Reaction. AAPM 2012, Charlotte, North Carolina, 2012.
42. Sell M, Titt U, Perles L, Mirkovic D, Mohan R, Bangert M, Oelfke U. Evaluation of Anayltical Proton Dose Predictions with a Lung-Like Plastic Phantom. AAPM 2012, Charolotte, North Carolina, 2012.
43. Titt U, Mirkovic D, Perles L, Peeler C, Liu A, Mohan R. Monto Carlo Phase Space Production to Model Magnetically Scanned Proton Beams for IMPT. AAPM 2012, Charolotte, North Carolina, 2012.
44. Mirkovic D, Titt U, Mohan R. Potential Clinical Impact of Dosimetric Uncertainties in Proton Therapy. AAPM 2012, Charolotte, North Carolina, 2012.
45. Perles L, Ibbott G, Blatnica A, Mirkovic D, Titt U, Gillin M, Mohan R. 3D Proton Dose Distributions in an Anthropomoric Lung Phantom, Comparing Monte Carlo, Film,and TLD Measurements. AAPM 2011, Vancouver, Canada, 2011.
46. Titt U, Mirkovic D, Ciangaru G, Mohan R. A novel tool for patient specific input quality assurance, 2011.
47. Mohan R, Mirkovic D, Titt U, Song X, Li H, Zhu X, Gillin M. Experimental Assessment of the Accuracy of a Semi-Empirical Model and a Monte Carlo Systen for Proton Dose Calculations for Highly Inhomogeneous Media. AAPM 2011, Vancouver, Canada, 2011.
48. Mirkovic D, Titt U, Fang C, Cox J, Mohan R. Monte Carlo Investigation of Dosimetric Uncertainties in Proton Therapy of Lung Cancer, 2011.
49. Randeniya S, Mirkovic D, Kry S, Titt U, Newhauser W, Howell R. Patient Specific Out-of-Field Dose Calculation Tool for 6MV and 18MV: Development and Validation. AAPM 2011, Vancouver, Canada, 2011.
50. Sawakuchi GO, Sahoo N, Gasparian GPR, Rodrigues MG, Archambault L, Titt U, Yukihara EG. Determination of the average LET of therapeutic proton beams using AL2 O3 C optically stimulated luminescenece (OSL) detectors. Phys Med Biol 55:4963-4976, 2010.
51. Titt U, Mirkovic D, Sawakuchi GO, Perles LA, Newhauser WD, Taddei PJ, Mohan R. Spot size manipulation for magnetically scanned proton beams, 2010.
52. Bues M, Titt U. Proton therapy, the Houston experience, 2009.
53. Bues M and Titt U. Proton therapy, the Houston experience, 2009.
54. Titt U. Results of a monte carlo study of a flattening filter free (FFF) clinac, 2009.
55. Titt U, Paganetti H, Mohan R. Comparing GEANT4 and MCNPX for joint research to minimize uncertainties in proton therapy. Med Phys 36:2624, 2008.
56. Zhu X, Titt U, Bues M, Sahoo N, Ciangaru G, Sawakuchi G, Poenisch F, Lii M, Zhang X, Arjomandy G, Suzuki K, Mohan R, Gillin M. Configuration and validation of a single gaussian dose model for scanning proton beams. Med Phys 36:2666, 2008.
57. Fontenot J, Bloch C, Followill D, Titt U, Zhang M, Newhauser W. Estimate of the uncertainty in relative secondary cancer risk calculations following proton therapy and intensity modulated x-ray therapy. Med Phys 36:2723, 2008.
58. Giebeler A, Zhu X, Starkschall G, Balter P, Titt U, Tucker S, Newhauser W. Estimation of uncertainty for the patient and compensator scatter correction factor in proton therapy d/mu calculations. Med Phys 36:2668, 2008.
59. Melancon A, Archambault L, Lee A, Kudchadker, R, Zhang L, Beddar S, Titt U, Dong L. In vivo detection of the anterior rectal wall using a scintillation fluid-filled rectal baloon for prostate cancer radiotherapy. Med Phys 36:2313, 2008.
60. Mirkovic D, Titt U, Sawakuchi G, Zhang X, Li Y, Mohan R. Monte carlo computation of the effective dose in scanning beam proton therapy. Med Phys 36:2613, 2008.
61. Titt U, Zheng Y, Vassiliev O, Newhauser W. Monte carlo investigation of collimator scatter in proton-therapy beams using the passive scattering technique. Med Phys 35:2797, 2008.
62. Titt U, Zhang X, Mirkovic D, Sawakuchi G, Mohan R. Monte carlo study of distal edge degradation in proton therapy due to heterogeneities. Med Phys 35:2798, 2008.
63. Taddei P, Mirkovic D, Fontenot J, Giebeler A, Zheng Y, Titt U, Woo S, Newhauser W. Reducing stray radiation dose for a pediatric patient receiving craniospinal irradiation with protons. Med Phys 35:2845, 2008.
64. Sawakuchi G, Titt U, Ciangaru G, Mirkovic D, Zhu X, Mohan R. The causes of the lateral envelope of low doses in scanning proton beamlets. Med Phys 36:2620, 2008.
65. Sawakuchi G, Titt U, Mohan R. The contribution of nuclear products of the laterl profile of the pencil scanning proton beams from the md anderson proton therapy center houston nozzle:the halo effect. Med Phys 35:2797, 2008.
66. Ding X, Sahoo N, Zhu X, Yang J, Arjomandy B, Lii M, Titt U, Mohan R, Smith A, Gillin M. Valdiation study of the GEANT 4 monte-carlo simulation of the proton dose distribution from passively scattered proton beam nozzles at the proton therapy center houston. Med Phys 35:2799, 2008.
67. Sawakuchi G, Titt U, Mirkovic D, Zhu X, Sahoo N, Bues M, Ciangaru G, Poenisch F, Suzuki K, Arjomandy B, Gillin M, Mohan R. Validation of an mcnpx monte carlo model of a discrete-spot scanning beam nozzle and evaluation of the beamlet lateral envelope dose. Med Phys 36:2782, 2008.
68. Smith A, Sahoo N, Ciangaru G, Polf J, Titt U. Concepts in proton therapy treatment planning, delivery and qa:19, 10/2007.
69. Newhauser WD, Fontenot JD, Zheng Y, Taddei P, Mirkovic D, Titt U, Zhu X, Sahoo N, Schaffner B, Langenegger A, Koch NC, Zhang X, Mohan R. A Monte Carlo based dose engine for proton radiotherapy treatment planning, AAPM 2007 Minneapolis, MN, USA. Med Phys 34:2406, 2007.
70. Vassiliev ON, Titt U, Mohan R. Low dose RBE of therapeutic proton beams, AAPM 2007 Minneapolis, MN, USA. Med Phys 34:2467, 2007.
71. Taddei P, Fontenot JD, Zheng Y, Mirkovic D, Titt U, Newhauser WD. Monte Carlo investigation of local shielding to reduce stray radiation doses to patients receiving proton therapy, AAPM 2007 Minneapolis, MN, USA. Med Phys 34:2471-2472, 2007.
72. Mohan R, Zhang X, Titt U, Zhu X, Dong L. Reducing uncertainties in proton therapy achieving what you see is what you get, AAPM 2007 Minneapolis MN, USA. Med Phys 34:2552, 2007.
73. Vassiliev ON, Kry SF, Chang J, Balter PA, Titt U, Mohan R. Stereotactic radiotherapy for lung cancer using flattening filter free accelerator, AAPM 2007 Minneapolis MN, USA. Med Phys 34:2491, 2007.
74. Titt U, Sahoo N, Zhu X, Ding X, Zheng Y, Gillin MT, Mohan R. Validation of the Monte Carlo model of the passive scattering nozzles at the Proton Therapy Center Houston, AAPM 2007 Minneapolis MN, USA. Med Phys 34:2503, 2007.
75. Sadagopan R, Titt U, Tailor R. Dose variation within lung tumor and in its fingerlike extension as a function of incident photon angle, AAPM 2006 Orlando FL, USA. Med Phys 33:2284, 2006.
76. Vassiliev ON, Titt U, Gillin MT, Mohan R. Dosimetric properties of 8 and 10 MV photon beams from a flattening filter free clinical accelerator, AAPM 2006 Orlando FL, USA. Med Phys 33:2294, 2006.
77. Newhauser WD, Zheng Y, Fontenot JD, Koch NC, Polf JC, Schaffner B, Titt U. Implementation of the varian eclipse system for proton therapy treatment planning, AAPM 2006 Orlando FL, USA. Med Phys 33:2284, 2006.
78. Titt U, Poenisch F, Kry SF, Zhu XR, Mohan R, Vassiliev ON. Monte Carlo simulation of backscatter in a flattening filter free clinac, AAPM 2006 Orlando FL, USA. Med Phys 33:2123, 2006.
79. Wareing TA, Failla G, Vassiliev ON, Barnett A, McGhee JM, Titt U, Horton Jr. JL, Mourtada F. Performance assessment of a deterministic method incorporating coupled photon-election transport for photon beam dose calculations on acquired CT, AAPM 2006 Orlando FL, USA. Med Phys 33:2292, 2006.
80. Ponisch F, Titt U, Vaaailiev ON, Kry SF, Mohan R. Properties of unflattened photon beams shaped by a multi leaf collimator, AAPM Orlando FL, USA. Med Phys 33:2131, 2006.
81. Vassiliev ON, Beddar AS, Krishnan, Briere TM, Gillin MT, Mohan R, Titt U. Treatment planning study of liver cancer treatments with a flattening filter free linear accelerator, AAPM 2006 Orlando FL, USA. Med Phys 33:2064, 2006.
82. Titt U, Zheng Y, Zhu XR, Mohan R, Newhauser WD,. Verification of a proton treatment-planning pencil-beam dose algorithm with Monte Carlo, AAPM 2006 Orlando FL, USA. Med Phys 33:2149, 2006.
83. Kry SF, Titt U Salehpour M, Ponisch F, Followill D, Vassiliev ON, Mohan R. A Monte Carlo simulation of out-of-field radiation from an 18-MV beam, AAPM 2005 Seattle WA, USA. Med Phys 32:1889, 2005.
84. Kry SF, Titt U, Ponisch F, Vassiliev ON, Salehpour M, Gillin M, Mohan R. A reduction in neutron production through the use of a flattening-filter-free accelerator, AAPM Seattle WA, USA. Med Phys 32:2146, 2005.
85. Vassiliev ON, Titt U, Ponisch F, Kry SF, Gillin MT, Mohan R. Dosimetric properties of photon beams from a flattening filter free clinical accelerator, AAPM 2005 Seattle, WA USA. Med Phys 32:1896, 2005.
86. Titt U, Vassiliev ON, Ponisch F, Kry SF, Gillin MT, Mohan R. Flattening filter free IMRT, first experimental results, AAPM 2005 Seattle, WA, USA. Med Phys 32:2144-2146, 2005.
87. Newhauser WD, Koch N, Hummel S, Ziegler M, Titt U. Monte Carlo simulations of a nozzle for the treatment of ocular tumors with high-energy proton beams, AAPM Seattlem, WA, USA. Med Phys 32:2165, 2005.
88. Poenisch F, Titt U, Vassiliev ON, Kry SF, Gillin MT, Mohan R. Validation of a highly detailed multi leaf collimator model by comparing Monte Carlo simulations to measurements, AAPM 2005 Seattle, WA, USA. Med Phys 32:2014, 2005.
89. Titt U, Vassiliev ON, Dong L, Liu H, Mohan R. A flattening filter free photon treatment concept evaluation with Monte Carlo, AAPM 2004 Pittsburgh USA. Med Phys 31:1811, 2004.
90. Fontenot J, Titt U, Newhauser WD. Design tools for proton therapy nozzles based on the double-scattering technique, AAPM Pittsburgh USA. Med Phys 31:1723, 2004.
91. Titt U, Ponisch F, Kry SF, Dong L, Stovall MS. Exploring stray radiation dose to photon radiation therapy patients with MCNPX, AAPM Pittsburgh USA. Med Phys 31:1887, 2004.

Manuals, Teaching Aids, Other Teaching Publications

1. Newhauser WD, Nill S, Titt U, Yan X, Smith AR. Neutron Area Monitoring for the Northeast Proton Therapy Center at the Massachusetts General Hospital. Northeast Proton Therapy Center Report NPTC-HD-102, 8/2000.
2. Newhauser WD, Yan X, Titt U. Measurements of the neutron dose equivalent rates outside the NPTC building at 100-MeV and 230-MeV proton beam energies. Northeast Proton Therapy Center Report NPTC-HD-107, 2000.
3. Newhauser WD, Titt U, Dexheimer D, Yan X, Nill S. Neutron shielding verification measurements and simulations for a 235-MeV proton therapy center. Northeast Proton Therapy Center Report Number NPTC-91, 2000.

Grant & Contract Support

Title: Understanding Biological and Physical Factors Affecting Response to Proton Therapy to Improve its Clinical Effectiveness
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Dragan Mirkovic
Duration: 3/1/2016 - 2/28/2019
 
Title: Improving the Clinical Effectiveness and Understanding of the Biophysical Basis of Proton Therapy: Core B - Clinical & Research Support at MDACC
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Radhe Mohan/Thomas DeLaney
Duration: 9/1/2015 - 8/31/2016
 
Title: Improving the Clinical Effectiveness and Understanding of the Biophysical Basis of Proton Therapy: Project 3 - Assessing accuracy of proton therapy and understanding the impact of physical and biophysical factors on its outcomes
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Radhe Mohan/Thomas DeLaney
Duration: 9/1/2015 - 8/31/2016
 
Title: Moving proton therapy towards its full potential by using fast Monte Carlo techniques, To be resubmitted
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Yepes
Duration: 3/1/2015 - 2/28/2018
 
Title: Advancing Linear Energy Transfer Models for Biologically Optimized Proton Therapy, To be resubmitted
Funding Source: MDACC-IRG
Role: Co-Investigator
Principal Investigator: David Grosshans
Duration: 2/15/2015 - 2/14/2016
 
Title: The future of particle therapy:Physics and biology of light ions, To be resubmitted
Funding Source: UTMDACC - The Center for Radiation Oncology Research
Role: Principal Investigator
Duration: 11/1/2014 - 10/31/2015
 
Title: Improving the clinical effectiveness and understanding of the biophysical basis - Project 3: Assessing accuracy of proton therapy and understanding the impact of physical and biophysical factors on its outcomes, To be resubmitted
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Radhe Mohan
Duration: 9/25/2014 - 8/31/2015
 
Title: Improving the clinical effectiveness and understanding of the biophysical basis - Core B: Clinical & Research Support at MDACC, To be resubmitted
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Radhe Mohan
Duration: 9/25/2014 - 8/31/2015
 
Title: Mapping Proton RBE Variability Using Automated Biology and Monte Carlo Techniques, To be resubmitted
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: David Grosshans, MD, PhD
Duration: 8/1/2014 - 7/31/2016
 
Title: The future of particle therapy: Physics and biology of light ions, To be resubmitted
Funding Source: Sister Institution Network Fund Application
Role: Principal Investigator
Duration: 2013 - 2016
 
Title: Intensity Modulated Particle Therapy, To be resubmitted
Funding Source: Sister Institution Network Fund
Role: Co-Investigator
Duration: 2/1/2012 - 9/30/2014
 
Title: Distal Edge Degradation in Proton Therapy and its repair, To be resubmitted
Funding Source: Varian Master Research Agreement (Project 9)
Role: Principal Investigator
Duration: 2/1/2009 - 5/31/2010
 
Title: Optimizing Proton Therapy - Project 3: Reducing Range Uncertainties in Proton Radiation Therapy, To be resubmitted
Funding Source: NIH/NCI
Role: Project Leader
Principal Investigator: Thomas DeLaney
Duration: 9/25/2008 - 7/31/2014
 
Title: Optimizing Proton Therapy - Core B: Clinical and Computational Support, To be resubmitted
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Thomas DeLaney
Duration: 9/25/2008 - 7/31/2014
 
Title: Optimizing Proton Therapy - Core B: Clinical and Computational Support, To be resubmitted
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Thomas DeLaney
Duration: 9/25/2008 - 7/31/2014
 
Title: Optimizing Proton Therapy - Project 3: Reducing Range Uncertainties in Proton Radiation Therapy, To be resubmitted
Funding Source: NIH/NCI
Role: Project Leader
Principal Investigator: Thomas DeLaney
Duration: 9/25/2008 - 7/31/2014
 
Title: Investigation of Dosimetric and Late Effects for Patients Receiving Proton Beam Therapy, To be resubmitted
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Co-Investigator
Duration: 9/1/2007 - 3/31/2009
 
Title: Conventional & Intensity-Modulated Radiation Therapy (IMRT) System Based on a Flattening-Filter Free (FFF) Lincear Accelerator, To be resubmitted
Funding Source: Varian Master Research Agreement (Project 3)
Role: Principal Investigator
Duration: 6/1/2004 - 8/31/2007
 
Title: Deterministic Radiotherapy Dose Evaluation, To be resubmitted
Funding Source: NIH
Role: Co-Investigator
Duration: 2004 - 2005
 
Title: Monte Carlo Neutron Shielding of Proton Therapy Facilities, To be resubmitted
Funding Source: Betchel Infrastructure Corporation
Role: Principal Investigator
Duration: 2001 - 2003

Last updated: 7/22/2015