Wafik Zaky, MD
Department of Pediatrics, Division of Pediatrics
Present Title & Affiliation
Primary Appointment
Associate Professor, Pediatrics Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1999 | Cairo University, Cairo, EG, MBBCh in Medicine |
Postgraduate Training
| 2011-2012 | Neuro-Oncology Clinical Fellowship, Children’s Hospital Los Angeles, Los Angeles, California |
| 2008-2011 | Pediatric Hematology Oncology Fellowship, NYU Medical Center, New York |
| 2006-2008 | Clinical Residency, SUNY Upstate Medical University, Syracuse, New York |
| 2005-2006 | Clinical Internship, Tod Children’s Hospital/ Western Reserve Care System, Youngstown, Ohio |
| 2001-2002 | Clinical Internship, Cairo University, Cairo |
Experience & Service
Extramural Institutional Committee Activities
Member, Brain Tumor Center Executive Committee, The University of Texas MD Anderson Cancer Center, 2021 - Present
Member, IRB Committee, The University of Texas MD Anderson Cancer Center, 2018 - Present
Member, PRS Executive Council, The University of Texas MD Anderson Cancer Center, 2016 - Present
Member, Clinical Research Committee, The University of Texas MD Anderson Cancer Center, 2015 - Present
Honors & Awards
| 2022 | 10 Years of Service Award at MDA Cancer Center, The University of Texas MD Anderson Cancer Center |
| 2022 | Leader Skills and Universal Skills for LEADing Others and Above - High Reliability, Leadership institution, leading the others |
| 2021 | Leading change course, Leadership institution, leading the others |
| 2021 | Excellence in Faculty Service Award, Pediatric Hematology-Oncology Fellowship Program, The University of Texas MD Anderson Cancer Center |
| 2021 | Holding difficult conversation course, Leadership institution, leading the others |
| 2021 | Innovative Thinking, Leadership institution, leading the others |
| 2021 | Leading with emotional intelligence course, Leadership institution, leading the others |
| 2021 | Managing performance course, Leadership institution, leading the others |
| 2021 | Team Decision Making, Leadership institution, leading the others |
| 2019 | Top Doctor in Houston, Houstonia |
| 2018 | Best Teaching Award, Pediatric Hematology-Oncology Fellowship Program, The University of Texas MD Anderson Cancer Center |
| 2017 | 5 Years of Service Award at MDA Cancer Center, The University of Texas MD Anderson Cancer Center |
| 2015 | Best Teaching Award, Pediatric Neuro-Oncology Team, The University of Texas MD Anderson Cancer Center |
| 2010 - 2011 | ASPHO Young Investigator Travel Stipend Award, American Society of Pediatric Hematology-Oncology |
| 2008 - 2009 | Excellence in Teaching Award, SUNY Upstate Medical University |
Professional Memberships
Selected Presentations & Talks
Regional Presentations
- 2022. Diffuse Midline Glioma. Is there a light at the end of the tunnel?. Conference. Diffuse Midline Glioma. Is there a light at the end of the tunnel?, US.
- 2021. Pediatric CNS tumors. Conference. Pediatric CNS tumors, US.
- 2014. Pediatric Brain Tumors in NF1. Conference. Pediatric Brain Tumors in NF1, TX, US.
- 2013. Recurrent progressive PNET, possible role for targeted therapy. Conference. Recurrent progressive PNET, possible role for targeted therapy, US.
National Presentations
- 2022. Pediatric Low-Grade Glioma and Diffuse Midline Glioma Management and Advances In Genomic Era. Conference. VII Neuro Oncology Course, US.
- 2021. Choroid plexus carcinoma. Conference. clinical trial proposal, US.
- 2019. Presenting ACNS2021 protocol for new diagnosis NGGCT. Conference. Presenting ACNS2021 protocol for new diagnosis NGGCT, US.
- 2018. CNS Brain Tumors. Conference. 18th International Symposium on Pediatric Neuro-Oncology – ISPNO. Denver, CO, US.
- 2018. Pilot Study of Circulating Tumor Cells in Pediatric High Grade Brain Tumors. Conference. Pilot Study of Circulating Tumor Cells in Pediatric High Grade Brain Tumors, US.
- 2012. Malignant transformation of pediatric low grade glioma. Conference. Grand Rounds. Houston, TX, US.
- 2011. Choroid plexus carcinoma and “Head Start” I-III experience. Conference. Children's Oncology Group, US.
- 2011. Atypical Teratoid Rhabdoid Tumors and "Head Start" I-III Experience. Conference. Atypical Teratoid Rhabdoid Tumors and "Head Start" I-III Experience, US.
- 2011. Aggressive Type of Tectal Gliomas with Malignant Degeneration, Treatment and Outcome, Literature Review. Conference. Aggressive Type of Tectal Gliomas with Malignant Degeneration, Treatment and Outcome, Literature Review, US.
- 2011. Intracranial Chondrosarcoma, Treatment and Outcome, Literature Review. Conference. Intracranial Chondrosarcoma, Treatment and Outcome, Literature Review, US.
- 2011. GBM with PNET-like features. Conference. GBM with PNET-like features, US.
- 2010. Ikaros deletion leads to chemotherapy resistance in pediatric acute lymphoblastic leukemia. Conference. Ikaros deletion leads to chemotherapy resistance in pediatric acute lymphoblastic leukemia, US.
- 2010. Ikaros Role in Acute Lymphoblastic Leukemia Relapse and Chemo-Resistance. Conference. Ikaros Role in Acute Lymphoblastic Leukemia Relapse and Chemo-Resistance. New York, NY, US.
Grant & Contract Support
| Date: | 2021 - Present |
| Title: | A Phase 2 Trial of Chemotherapy followed by Response Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor |
| Funding Source: | 3% efforts |
| Role: | Co-Chair |
| Date: | 2020 - Present |
| Title: | 2018-0840: Newly Diagnosed with Medulloblastoma and Other Embryonal Tumors: Induction Chemotherapy Followed by Consolidation of Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue |
| Funding Source: | 1% efforts |
| Role: | Co-PI |
| Date: | 2020 - 2021 |
| Title: | Combinatorial epigenetic strategies for GBM to enhance immune sensitization and overcome radiation resistance |
| Funding Source: | Brain Cancer Spore |
| Role: | CO-I |
| Date: | 2019 - 2024 |
| Title: | Communication Plan Early Through End of Life (COMPLETE) Intervention. R01 CA235632, Moody/Ferguson/Haase (PIs) |
| Funding Source: | NIH/NCI |
| Role: | CO-I |
| Date: | 2019 - 2022 |
| Title: | Evaluation of Dual Targeted kinase Inhibitor Therapy for Adult and Pediatric High Grade Gliomas |
| Funding Source: | IGNITE Program |
| Role: | CO-I |
| Date: | 2019 - 2020 |
| Title: | PDGFRa-specific Car T Cells for the Treatment of Refractory Pediatric High Grade Gliomas |
| Funding Source: | IRG |
| Role: | CO-I |
| Date: | 2019 - 2020 |
| Title: | PDGFRα-specific CAR T cells for the Treatment of Refractory Pediatric High Grade Gliomas |
| Funding Source: | Swim across America |
| Role: | CO-I |
| Date: | 2018 - 2020 |
| Title: | Epigenetic of Pediatric Osteosarcoma |
| Funding Source: | Division of Pediatric Research Award |
| Role: | Co-PI |
| Date: | 2018 - 2023 |
| Title: | Pediatric Solid Tumors Comprehensive Data Resource Core |
| Funding Source: | CPRIT Core Grant |
| Role: | Collaborator |
| Date: | 2018 - Present |
| Title: | Study of a Novel Deubiquitylase in Medulloblastoma |
| Funding Source: | National Institutes of Health |
| Role: | Collaborator |
| ID: | 2R01NS079715 |
| Date: | 2018 - 2023 |
| Title: | Onc201 study (2018-0178) in Newly Diagnosed Diffuse Intrinsic Pontine Glioma and Recurrent/Refractory Pediatric H3 K27M Gliomas |
| Funding Source: | Oncoceutics pharma |
| Role: | Co-PI |
| Date: | 2017 - 2019 |
| Title: | Circulating Biomarkers in Pediatric Gliomas and Brain Tumors |
| Funding Source: | ARD Foundation |
| Role: | Co-PI |
| Date: | 2016 - Present |
| Title: | Development of Adoptive PDGFR-specific CAR T cells for the Treatment of Refractory Pediatric High Grade Gliomas |
| Funding Source: | Brain SPORE |
| Role: | Co-PI |
| Date: | 2016 - Present |
| Title: | Phase I Trial of Dasatinib (PDGFR and SRC Inhibitor), Temsirolimus and Cyclophosphamide in Patients with Advanced Solid Tumors |
| Funding Source: | High Impact Clinical Research Support Program |
| Role: | PI |
| Date: | 2015 - 2020 |
| Title: | Phase I Trial of Dasatinib, Temsirolimus and Cyclophosphamide in Patients with Advanced Solid Tumors |
| Funding Source: | Pediatric Clinical Innovator Award |
| Role: | PI |
| Date: | 2015 - Present |
| Title: | Phase I Trial of Dasatinib (PDGFR and SRC Inhibitor), Temsirolimus and Cyclophosphamide in Patients with Advanced Solid Tumors |
| Funding Source: | UTMDACC Institutional Research Grant |
| Role: | PI |
| Date: | 2015 - Present |
| Title: | A Novel Signal Transduction Inhibitors Combination Phase I Trial for Pediatric Patients with Advanced Brain Tumors |
| Funding Source: | Mathew Larsen Foundation |
| Role: | PI |
| Date: | 2014 - 2015 |
| Title: | Clinical Evaluation of Targeted Therapy for Advanced Pediatric High Grade Gliomas |
| Funding Source: | Marnie Rose Foundation |
| Role: | PI |
| Date: | 2014 - Present |
| Title: | Targeted Therapy for Advanced Pediatric High Grade Gliomas |
| Funding Source: | UTMDACC Institutional Research Grant |
| Role: | PI |
| Date: | 2014 - Present |
| Title: | Targeted Therapy for Advanced Pediatric Brain Tumors Harboring Aberrant RAS-RAF-MAPK Signaling |
| Funding Source: | Team Connor Foundation |
| Role: | PI |
| Date: | 2014 - Present |
| Title: | A Pilot Study of Personalized Therapy for Pediatric Recurrent or Refractory Brain Tumors |
| Funding Source: | UTMDACC Institutional Research Grant |
| Role: | PI |
| Date: | 2013 - Present |
| Title: | Personalized Therapy for Pediatric Recurrent or Refractory Brain Tumors |
| Funding Source: | UTMDACC Institutional Research Grant |
| Role: | PI |
| Date: | 2011 - 2012 |
| Title: | Malignant transformation of Pediatric Non-Pilocytic Astrocytoma |
| Funding Source: | St. Baldrick's Foundation |
| Role: | PI |
| Date: | 2010 - 2011 |
| Title: | IKZF1 deletion and chemotherapy resistance in pediatrics acute lymphoblastic leukemia |
| Funding Source: | St. Baldrick's Foundation |
| Role: | PI |
| Title: | Evaluation of dual targeted kinase inhibitor therapy for adult and pediatric high grade gliomas |
| Funding Source: | National Institutes of Health, IGNITE program |
| Role: | Collaborator |
| Title: | Choroid Plexus Carcinoma: A Contemporary Multi-Institutional Analysis of Genotype, Phenotype and Outcomes in Young Children |
| Funding Source: | American Brain Tumor Association |
| Role: | Co-PI |
Selected Publications
Peer-Reviewed Articles
- Lee, KL, Johnson, JM, Kralik, SF, Ramírez Mateo, SV, Grosshans, DR, McAleer, MF, Zaky, W, Baxter, PA, Lin, FY, Chintagumpala, M, Paulino, AC, McGovern, SL. Pseudoprogression in Pediatric Spinal Pilocytic Astrocytoma and Myxopapillary Ependymoma after Proton Therapy. Pediatric Blood and Cancer 72(9), 2025. e-Pub 2025. PMID: 40563211.
- Stitzlein, LM, Baig, M, Chandra, J, McGovern, SL, Paulino, AC, Ketonen, L, Khatua, S, Zaky, W. Phase I Study of Vorinostat and Temsirolimus in Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma. Pediatric Blood and Cancer 72(5), 2025. e-Pub 2025. PMID: 40000388.
- Karajannis, MA, Onar-Thomas, A, Lin, T, Baxter, PA, Boue, DR, Cole, B, Fuller, C, Haque, SS, Jabado, N, Lucas, JT, MacDonald, SM, Matsushima, C, Patel, N, Pierson, CR, Souweidane, MM, Thomas, D, Walsh, MF, Zaky, W, Leary, SE, Gajjar, A, Fouladi, M, Cohen, KJ. Phase 2 trial of veliparib, local irradiation, and temozolomide in patients with newly diagnosed high-grade glioma. Neuro-oncology 27(4):1092-1101, 2025. e-Pub 2025. PMID: 39560182.
- Gajjar, A, Mahajan, A, Bale, T, Bowers, DC, Canan, L, Chi, SN, Cluster, A, Cohen, KJ, Cole, B, Coven, SL, Darlington, W, Dorris, K, Elster, J, Ermoian, RP, Franson, A, George, E, Helgager, J, Landi, D, Lin, C, Metrock, L, Nanda, R, Palmer, JD, Partap, S, Plant, A, Pruthi, S, Reynolds, R, Stearns, D, Storm, PB, Wang, AC, Wang, LD, Whipple, NS, Zaky, W, McMillian, NR, Ramakrishnan, S. Pediatric Central Nervous System Cancers, Version 2.2025. JNCCN Journal of the National Comprehensive Cancer Network 23(3):113-130, 2025. e-Pub 2025. PMID: 40073837.
- Stitzlein, LM, Nam, D, Hernandez, FA, Patel, KH, Poche, A, Ma, H, Impelman, K, Gumin, J, Wang, H, Wang, J, Gadd, S, Zaky, W, Becher, OJ, Dudley, RW, Lang Jr, FF, Sareddy, GR, Chandra, J. Combined inhibition of lysine-specific demethylase 1 and kinase signaling as a preclinical treatment strategy in glioblastoma. Neuro-Oncology Advances 7(1), 2025. e-Pub 2025. PMID: 41497449.
- Osorio, DS, Yankelevich, M, Lafay-Cousin, L, Zaky, W. An overview of the diagnosis and management of Choroid Plexus tumors. Advances in Cancer Research 167:103-139, 2025. e-Pub 2025. PMID: 41198335.
- Yankelevich, M, Zaky, W, Lafay-Cousin, L, Osorio, DS, Adamski, J, Kordes, U, Finlay, J, Prados, M, Mueller, S. Marrow-ablative consolidation chemotherapy and molecular targeted therapy delivered in a risk-adapted manner for newly diagnosed children with choroid plexus carcinoma. Neuro-Oncology Advances 6(1), 2024. e-Pub 2024. PMID: 39036438.
- Phadnis, SS, Wang, X, Daw Bitar, N, Herzog, CE, Subbiah, IM, Zaky, W, Gouda, MA, Morani, A, Amini, B, Harrison, DJ, Piha-Paul, SA, Meric-Bernstam, F, Gorlick, R, Schwartz, CL, Subbiah, V. Everolimus in combination with vandetanib in children, adolescents, and young adults. ESMO Open 8(6), 2023. e-Pub 2023. PMID: 37879233.
- Zaky, W, Ragoonanan, D, Batth, IS, Dao, L, Wang, J, Xia, X, Daw Bitar, N, Gill, JB, Khatua, S, Li, S. Automated Capture and Analysis of Circulating Tumor Cells in Pediatric, Adolescent and Young Adult Patients with Central Nervous System Tumors. Cancers 15(15), 2023. e-Pub 2023. PMID: 37568669.
- Matsui JK, Allen PK, Perlow HK, Johnson JM, Paulino AC, McAleer MF, Fouladi M, Grosshans DR, Ghia AJ, Li J, Zaky WT, Chintagumpala MM, Palmer JD, McGovern SL. Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience. J Neurooncol 163(3):717-726, 2023. e-Pub 2023. PMID: 37440097.
- Pokhylevych, H, Khose, S, Amer, A, Alhasan, H, Kaya, D, Johnson, R, Fuller, GN, Gruschkus, SK, Zaky, W, Weinberg, J, Johnson, JM. Retrospective Analysis of Imaging Characteristics of Tectal Gliomas. Journal of computer assisted tomography 47(1):136-143, 2023. e-Pub 2023. PMID: 36598462.
- Gregory, TA, Mastall, M, Lin, Y, Hess, KR, Yuan, Y, Martin-Bejarano Garcia, M, Fuller, GN, Alfaro, KD, Gule-Monroe, MK, Huse, J, Khatua, S, Rao, G, Sandberg, DI, Wefel, JS, Yeboa, DN, Paulino, AC, McGovern, SL, Zaky, W, Mahajan, A, Suki, D, Weathers, S, Harrison, R, De Groot, J, Puduvalli, VK, Penas-Prado, M, Majd, NK. Characterization of recurrence patterns and outcomes of medulloblastoma in adults. Neuro-Oncology Advances 5(1), 2023. e-Pub 2023. PMID: 37114244.
- Pokhylevych H, Khose S, Gule-Monroe MK, Chen MM, Fuller G, Gruschkus SK, Sadighi Z, Zaky W, Sandberg DI, McGovern SL, Johnson JM. Contrast Enhancement Patterns in Pediatric Glioblastomas. J Comput Assist Tomogr 47(1):115-120, 2023. e-Pub 2022. PMID: 36112052.
- Gajjar, A, Mahajan, A, AbdelBaki, MS, Anderson, C, Antony, R, Bale, T, Bindra, RS, Bowers, DC, Cohen, KJ, Cole, B, Dorris, K, Ermoian, RP, Franson, A, Helgager, J, Landi, D, Lin, C, Metrock, L, Nanda, R, Palmer, JD, Partap, S, Plant, A, Pruthi, S, Reynolds, RK, Ruggieri, P, Stearns, D, Storm, PB, Wang, AC, Warren, KE, Whipple, NS, Zaky, W, McMillian, NR, Pluchino, L. Pediatric Central Nervous System Cancers, Version 2.2023. JNCCN Journal of the National Comprehensive Cancer Network 20(12):1339-1362, 2022. e-Pub 2022. PMID: 36509072.
- Upadhyay R, Liao K, Grosshans DR, McGovern SL, McAleer MF, Zaky W, Chintagumpala MM, Mahajan A, Yeboa DN, Paulino AC. Quantifying the risk and dosimetric variables of symptomatic brainstem injury after proton beam radiation in pediatric brain tumors. Neuro Oncol 24(9):1571-1581, 2022. e-Pub 2022. PMID: 35157767.
- Upadhyay R, Khose S, Pokhylevych H, Paulino AC, McAleer MF, Ghia A, Li J, Yeboa DN, Loghin M, Harrison R, O'Brien B, Kamiya-Matsuoka C, De Groot J, Puduvalli VK, Tatsui C, Alvarez-Breckenridge C, Prabhu S, Rhines L, Zaky W, Lin F, Weinberg JS, Fuller G, Sandberg DI, Johnson JM, McGovern SL. Patterns of failure after radiation therapy in primary spinal high-grade gliomas: A single institutional analysis. Neurooncol Adv 4(1):vdac129, 2022. e-Pub 2022. PMID: 36128585.
- Gardner, S, Tarapore, RS, Allen, J, McGovern, SL, Zaky, W, Odia, Y, Daghistani, D, Diaz, Z, Hall, MD, Khatib, Z, Koschmann, C, Cantor, E, Kurokawa, R, MacDonald, T, Aguilera, D, Vitanza, NA, Mueller, S, Kline, C, Lu, G, Allen, JE, Khatua, S. Phase i dose escalation and expansion trial of single agent ONC201 in pediatric diffuse midline gliomas following radiotherapy. Neuro-Oncology Advances 4(1), 2022. e-Pub 2022. PMID: 36382108.
- Olsthoorn IM, Holland AA, Hawkins RC, Cornelius AE, Baig MU, Yang G, Holland DC, Zaky W, Stavinoha PL. Sleep Disturbance and Its Association With Sluggish Cognitive Tempo and Attention in Pediatric Brain Tumor Survivors. Front Neurosci 16:918800, 2022. e-Pub 2022. PMID: 35812214.
- Dussupt V, Sankhala RS, Mendez-Rivera L, Townsley SM, Schmidt F, Wieczorek L, Lal KG, Donofrio GC, Tran U, Jackson ND, Zaky WI, Zemil M, Tritsch SR, Chen WH, Martinez EJ, Ahmed A, Choe M, Chang WC, Hajduczki A, Jian N, Peterson CE, Rees PA, Rutkowska M, Slike BM, Selverian CN, Swafford I, Teng IT, Thomas PV, Zhou T, Smith CJ, Currier JR, Kwong PD, Rolland M, Davidson E, Doranz BJ, Mores CN, Hatziioannou T, Reiley WW, Bieniasz PD, Paquin-Proulx D, Gromowski GD, Polonis VR, Michael NL, Modjarrad K, Joyce MG, Krebs SJ. Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations. Nat Immunol 22(12):1503-1514, 2021. e-Pub 2021. PMID: 34716452.
- Mohiuddin S, Maraka S, Baig MU, Gupta S, Muzzafar T, Valyi-Nagy T, Lindsay H, Moody K, Razvi S, Paulino A, Slavin K, Gondi V, McCutcheon I, Zaky W, Khatua S. Corrigendum to "Case series of diffuse extraneural metastasis in H3F3A mutant high-grade gliomas: Clinical, molecular phenotype and literature review" [J. Clin. Neurosci. 89 (2021) 405-411]. J Clin Neurosci 93:286, 2021. e-Pub 2021. PMID: 34344600.
- Nantavithya C, Paulino AC, Liao K, Woodhouse KD, McGovern SL, Grosshans DR, McAleer MF, Khatua S, Chintagumpala MM, Majd N, Zaky W, Yeboa DN. Observed-to-expected incidence ratios of second malignant neoplasms after radiation therapy for medulloblastoma: A Surveillance, Epidemiology, and End Results analysis. Cancer 127(13):2368-2375, 2021. e-Pub 2021. PMID: 33721338.
- Gibson A, Baig MU, Mohiuddin S, Zaky W. Neither iatrogenic nor hereditary cause: A rare case of anaphylaxis to low sorb tubing used for infusions. Pediatr Blood Cancer 68(4):e28800, 2021. e-Pub 2021. PMID: 33164273.
- Taku N, Woodhouse KD, Liao KP, Anakwenze CP, Harrison RA, Zaky W, Paulino AC, Yeboa DN. Patterns of care for pediatric patients with newly-diagnosed grade II gliomas. Childs Nerv Syst. e-Pub 2021. PMID: 33404712.
- Mak DY, Laperriere N, Ramaswamy V, Bouffet E, Murray JC, McNall-Knapp RY, Bielamowicz K, Paulino AC, Zaky W, McGovern SL, Okcu MF, Tabori U, Atwi D, Dirks PB, Taylor MD, Tsang DS, Bavle A. Reevaluating surgery and re-irradiation for locally recurrent pediatric ependymoma-a multi-institutional study. Neurooncol Adv 3(1):vdab158, 2021. e-Pub 2021. PMID: 34988448.
- Dao L, Ragoonanan D, Batth I, Satelli A, Foglesong J, Wang J, Zaky W, Gill JB, Liu D, Albert A, Gordon N, Huh W, Harrison D, Herzog C, Kleinerman E, Gorlick R, Daw N, Li S. Prognostic Value of Cell-Surface Vimentin-Positive CTCs in Pediatric Sarcomas. Front Oncol 11:760267, 2021. e-Pub 2021. PMID: 34956881.
- Sun Y, Bailey CP, Sadighi Z, Zaky W, Chandra J. . Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities. J Neurooncol 150(1):17-26, 2020. e-Pub 2020. PMID: 32504402.
- Bailey CP, Figueroa M, Gangadharan A, Yang Y, Romero MM, Kennis BA, Yadavilli S, Henry V, Collier T, Monje M, Lee DA, Wang L, Nazarian J, Gopalakrishnan V, Zaky W, Becher OJ, Chandra J. Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in pediatric high grade glioma (pHGG). Neuro Oncol 22(9):1302-1314, 2020. e-Pub 2020. PMID: 32166329.
- Khatua S, Cooper LJN, Sandberg DI, Ketonen L, Johnson JM, Rytting ME, Liu DD, Meador H, Trikha P, Nakkula RJ, Behbehani GK, Ragoonanan D, Gupta S, Kotrotsou A, Idris T, Shpall EJ, Rezvani K, Colen R, Zaky W, Lee DA, Gopalakrishnan V. Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma. Neuro Oncol 22(8):1214-1225, 2020. e-Pub 2020. PMID: 32152626.
- Sen S, Tanaka R, Khatua S, Zaky W, Janku F, Penas-Prado M, Weathers SP, Behrang A, Roszik J, Subbiah V. Dual inhibition of BRAF and mTOR in BRAF V600E -mutant pediatric, adolescent, and young adult brain tumors. Cold Spring Harb Mol Case Stud 6(4), 2020. e-Pub 2020. PMID: 32843426.
- Mullarkey MP, Nehme G, Mohiuddin S, Ballester LY, Bhattacharjee MB, Trivedi D, Shah MN, Fuller GN, Zaky W, Sandberg DI. Posttreatment Maturation of Medulloblastoma into Gangliocytoma: Report of 2 Cases. Pediatr Neurosurg 55(4):1-10, 2020. e-Pub 2020. PMID: 32882694.
- Phadnis SS, Chen L, Wang WL, Migden MR, Zaky W. Disseminated anaplastic pleomorphic xanthoastrocytoma with posttreatment fat necrosis during combined BRAF and MEK inhibitors therapy. Pediatr Blood Cancer 66(12):e27974, 2019. e-Pub 2019. PMID: 31502413.
- Chi AS, Tarapore RS, Hall MD, Shonka N, Gardner S, Umemura Y, Sumrall A, Khatib Z, Mueller S, Kline C, Zaky W, Khatua S, Weathers SP, Odia Y, Niazi TN, Daghistani D, Cherrick I, Korones D, Karajannis MA, Kong XT, Minturn J, Waanders A, Arillaga-Romany I, Batchelor T, Wen PY, Merdinger K, Schalop L, Stogniew M, Allen JE, Oster W, Mehta MP. Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201. J Neurooncol 145(1):97-105, 2019. e-Pub 2019. PMID: 31456142.
- Kennis BA, Michel KA, Brugmann WB, Laureano A, Tao RH, Somanchi SS, Einstein SA, Bravo-Alegria JB, Maegawa S, Wahba A, Kiany S, Gordon N, Silla L, Schellingerhout D, Khatua S, Zaky W, Sandberg D, Cooper L, Lee DA, Bankson JA, Gopalakrishnan V. Correction to: Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI. J Neurooncol 142(3):409, 2019. e-Pub 2019. PMID: 30968268.
- Kennis BA, Michel KA, Brugmann WB, Laureano A, Tao RH, Somanchi SS, Einstein SA, Bravo-Alegria JB, Maegawa S, Wahba A, Kiany S, Gordon N, Silla L, Schellingerhout D, Khatua S, Zaky W, Sandberg D, Cooper L, Lee DA, Bankson JA, Gopalakrishnan V. Monitoring of Intracerebellarly-Administered Natural Killer Cells with Fluorine-19 MRI. J Neurooncol 142(3):395-407, 2019. e-Pub 2019. PMID: 30788681.
- Zaky W, Patil SS, Park M, Liu D, Wang WL, Wani KM, Calle S, Ketonen L, Khatua S. Ganglioglioma in children and young adults: single institution experience and review of the literature. J Neurooncol 139(3):739-747, 2018. e-Pub 2018. PMID: 29882043.
- Eterovic AK, Maher OM, Chandra J, Chen K, Huse J, Zaky W. Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing. J Natl Compr Canc Netw 16(6):683-691, 2018. e-Pub 2018. PMID: 29891519.
- Patel RP, Sitton CW, Ketonen LM, Hou P, Johnson JM, Romo S, Fletcher S, Shah MN, Kerr M, Zaky W, Rytting ME, Khatua S, Sandberg DI. Phase-contrast cerebrospinal fluid flow magnetic resonance imaging in qualitative evaluation of patency of CSF flow pathways prior to infusion of chemotherapeutic and other agents into the fourth ventricle. Childs Nerv Syst 34(3):481-486, 2018. e-Pub 2018. PMID: 29170836.
- Gilbert AR, Zaky W, Gokden M, Fuller CE, Ocal E, Leeds NE, Fuller GN. Extending the Neuroanatomic Territory of Diffuse Midline Glioma, K27M Mutant: Pineal Region Origin. Pediatr Neurosurg 53(1):59-63, 2018. e-Pub 2018. PMID: 29131126.
- Wong KK, All S, Waxer J, Olch AJ, Venkatramani R, Dhall G, Davidson TB, Zaky W, Finlay JL. Radiotherapy after high-dose chemotherapy with autologous hematopoietic cell rescue: Quality assessment of Head Start III. Pediatr Blood Cancer 64(10), 2017. e-Pub 2017. PMID: 28379644.
- Maher OM, Khatua S, Mukherjee D, Olar A, Lazar A, Luthra R, Liu D, Wu J, Ketonen L, Zaky W. Primary intracranial soft tissue sarcomas in children, adolescents, and young adults: single institution experience and review of the literature. J Neurooncol 127(1):155-63, 2016. e-Pub 2016. PMID: 26718692.
- Sandberg DI, Rytting M, Zaky W, Kerr M, Ketonen L, Kundu U, Moore BD, Yang G, Hou P, Sitton C, Cooper LJ, Gopalakrishnan V, Lee DA, Thall PF, Khatua S. Methotrexate administration directly into the fourth ventricle in children with malignant fourth ventricular brain tumors: a pilot clinical trial. J Neurooncol 125(1):133-41, 2015. e-Pub 2015. PMID: 26255071.
- Zaky W, Dhall G, Khatua S, Brown RJ, Ginn KF, Gardner SL, Yildiz VO, Yankelevich M, Finlay JL. Choroid plexus carcinoma in children: the Head Start experience. Pediatr Blood Cancer 62(5):784-9, 2015. e-Pub 2015. PMID: 25662896.
- Vitanza NA, Zaky W, Blum R, Meyer JA, Wang J, Bhatla T, Morrison DJ, Raetz EA, Carroll WL. Ikaros deletions in BCR-ABL-negative childhood acute lymphoblastic leukemia are associated with a distinct gene expression signature but do not result in intrinsic chemoresistance. Pediatr Blood Cancer 61(10):1779-85, 2014. e-Pub 2014. PMID: 24976218.
- Khatua S, Hou P, Bodiwala R, Wolff J, Hamilton J, Patil S, Zaky W, Mahajan A, Ketonen L. Preliminary experience with diffusion tensor imaging before and after re-irradiation treatments in children with progressive diffuse pontine glioma. Childs Nerv Syst 30(5):925-30, 2014. e-Pub 2014. PMID: 24395582.
- Moonat H, Maher O, Silva J, Almohammedsalim A, Khatua S, Zaky W. Infection Mimicking Malignancy: Two Cases to Learn From. Progressive Science 1(5), 2014. e-Pub 2014.
- Zaky W, Dhall G, Ji L, Haley K, Allen J, Atlas M, Bertolone S, Cornelius A, Gardner S, Patel R, Pradhan K, Shen V, Thompson S, Torkildson J, Sposto R, Finlay JL. Intensive induction chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for young children newly-diagnosed with central nervous system atypical teratoid/rhabdoid tumors: the Head Start III experience. Pediatr Blood Cancer 61(1):95-101, 2014. e-Pub 2014. PMID: 23934933.
- Zaky W, Wellner M, Brown RJ, Blüml S, Finlay JL, Dhall G. Treatment of children with diffuse intrinsic pontine gliomas with chemoradiotheapy followed by a combination of temozolmide, irinotecan, and bevacizumab. Pediatr Hematol Oncol 30(7):623-32, 2013. e-Pub 2013. PMID: 24050762.
- Dhir N, Zaky W, Zomorodian T, Dhall G. Chronic myeloid leukemia as a second malignant neoplasm in a patient with medulloblastoma after treatment with chemotherapy and irradiation: a case report and review of the literature. Pediatr Hematol Oncol 30(1):28-9, 2013. e-Pub 2013. PMID: 23273112.
- Gardner S, Allen J, Tarpore R, Zaky W, Odia Y, Hall M, Daghistan D, Khatib Z, Koschman C, Cantor E, Aguilera D, MacDonald T, Fouladi M, McGovern S, Vitanza N, Diaz Z, Gurangrong L, Khatua S. Phase I dose escalation and expansion trial of single agent ONC201 in recurrent or refractory pediatric H3 K27M-mutant gliomas. Journal of Clinical Oncology.
- Hammoud RA, Zaky W, Tran DQ. Actinomycosis presenting as a thigh mass in a pediatric patient with suspected X-linked carrier chronic granulomatous disease and transient skewed lionization. Pediatric Infectious Diseases Society.
Invited Articles
- Khatua S, Mangum R, Bertrand KC, Zaky W, McCall D, Mack SC. Pediatric ependymoma: current treatment and newer therapeutic insights. Future Oncol 14(30):3175-3186, 2018. e-Pub 2018. PMID: 30418040.
- Bailey CP, Figueroa M, Mohiuddin S, Zaky W, Chandra J. Cutting Edge Therapeutic Insights Derived from Molecular Biology of Pediatric High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG). Bioengineering (Basel) 5(4), 2018. e-Pub 2018. PMID: 30340362.
- Zaky W, Manton C, Miller CP, Khatua S, Gopalakrishnan V, Chandra J. The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities. Cancer Metastasis Rev 36(4):617-633, 2017. e-Pub 2017. PMID: 29071526.
- Khatua S, Zaky W. The biologic era of childhood medulloblastoma and clues to novel therapies. Future Oncol 10(4):637-45, 2014. e-Pub 2014. PMID: 24754593.
- Khatua S, Zaky W. Diffuse intrinsic pontine glioma: time for therapeutic optimism. CNS Oncol 3(5):337-48, 2014. e-Pub 2014. PMID: 25363006.
Review Articles
- Elgehiny, A, Fan, AE, Frost, M, He, J, Gary, S, Osorio, DS, Zaky, W, Zhou, L, Kang, K, Zhang, Z, Fueyo-Margareto, J, Gomez-Manzano, C, Thompson, EM, Bernstock, J, Friedman, GK. Clinical and translational progress in oncolytic virotherapy for pediatric CNS tumors. Journal of neuro-oncology 177(1), 2026. e-Pub 2026. PMID: 41741902.
- He, J, Connors, JS, Meador, A, Xu, S, Meador, H, Jiang, H, Fueyo-Margareto, J, Gomez-Manzano, C, Friedman, GK, Zaky, W, Sadighi, ZS, Slopis, JM, Ahmad, AH. Immunotherapy-related neurotoxicity in the central nervous system of children with cancer. Neuro-oncology 27(3):625-643, 2025. e-Pub 2025. PMID: 39535217.
- Osorio, DS, Yankelevich, M, Zaky, W, Lafay-Cousin, L, Margol, AS, Toll, SA, Quiroz, L, Fox, JE, Hanson, D, Gardner, S, Prados, M, Mueller, S, Finlay, J. Marrow-ablative consolidation chemotherapy (HDCT) to decrease the development of choroid plexus carcinoma (CPC) specific relapse in high-risk TP53-mutated (germline or somatic) young children with newly diagnosed CPC. Journal of Clinical Oncology 42:2088, 2024. e-Pub 2024.
- Odia, Y, Koschmann, C, Vitanza, NA, de Blank, P, Aguilera, D, Allen, J, Daghistani, D, Hall, MD, Khatib, Z, Kline, C, MacDonald, T, Mueller, S, Faison, SL, Allen, JE, Naderer, OJ, Ramage, SC, Tarapore, RS, McGovern, SL, Khatua, S, Zaky, W, Gardner, S. Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3 K27M-mutant glioma. Neuro-oncology 26(Supplement_2):S155-S164, 2024. e-Pub 2024. PMID: 38400780.
- He, J, Munir, F, Ragoonanan, D, Zaky, W, Khazal, SJ, Tewari, P, Fueyo-Margareto, J, Gomez-Manzano, C, Jiang, H. Combining CAR T Cell Therapy and Oncolytic Virotherapy for Pediatric Solid Tumors. Immuno 3(1):37-56, 2023. e-Pub 2023.
- Ragoonanan D, Khazal SJ, Mejia R, Ewing L, Durand JB, Bashoura L, Tayar J, Dailey Garnes N, Petropoulos D, Tewari P, Bhatti M, Ahmad AH, Cortes J, Razvi S, McBeth K, Swinford R, Shoberu B, Waseemuddin W, Chi L, Gill JB, Zaky W, Daw N, Gutierrez C, Tereffe W, Kebriaei P, Rezvani K, Shpall EJ, Champlin RE, Mahadeo KM. Case Discussion and Literature Review: Cancer Immunotherapy, Severe Immune-Related Adverse Events, Multi-Inflammatory Syndrome, and Severe Acute Respiratory Syndrome Coronavirus 2. Front Oncol 11:625707, 2021. e-Pub 2021. PMID: 33614514.
- Zaky W, Finlay JL. Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives. Pediatr Blood Cancer 65(7):e27031, 2018. e-Pub 2018. PMID: 29528196.
Professional Educational Materials
- . Pediatrics Brain Tumors, Fellowship Program, 2015.
Editorials
- Zaky W. Revisiting Management of Pediatric Brain Tumors with New Molecular Insights. Cell 164(5):844-6, 2016. PMID: 26919424.
Abstracts
- Sadighi Z, Pokhylevych H, Gule-Monroe M, Chen M, Fuller G, Gruschkus S, Sandberg D, McGovern S, McAleer MF, Zaky W, Khatua S, Johnson J. Pediatric glioblastomas contrast enhancement pattern is predictive of survival. Annual meeting of the International Society of Pediatric Neuro-Oncology, 2020. e-Pub 2020.
- Sridharan S, Harmanci A, Sharma A, LaYi, Kennis B, Dobson T, Swaminathan J, Haltom A, Khatua S, Tarapore RS, Allen JE, Cheng D, Zaky W, Gopalakrishnan V. ONC201 in Refractory DIPG: Transcriptomic and Proteomic Analyses. Annual meeting of the American Association of Cancer Research, 2020. e-Pub 2020.
- A Gibson A, M Baig M, S Raza S, D Grosshans D, W Zaky W. Clinical characterization and outcome; our experience of chordomas in pediatric and young adults. Annual meeting of the International Society of Pediatric Neuro-Oncology, Japan, 2020. e-Pub 2020.
- Baig, M, McAleer, M, Grosshans, D, Paulino, A, Baxter, P, Chintagumpala, M, Zaky, W, McGovern, S. Salavage radiation therapy for progressive and or relapsed pediatric medulloblastoma. Annual meeting of the International Society of Pediatric Neuro-Oncology, Japan, 2020. e-Pub 2020.
- Baig M, McGovern, S, McAleer, M, Grosshans, D, Paulino, A, Woodhouse, K, Zaky, W, Stavinoha, P. Neurocognitive profile of pediatric medulloblastoma patients prior to radiation therapy. Annual meeting of the International Society of Pediatric Neuro-Oncology, Japan, 2020. e-Pub 2020.
- Gardner S, Koschmann CJ, Tarapore RS, Allen J, Zaky W, Odia Y, Hall M, Daghistani D, Khatib Z, Aguilera D, MacDonald TJ, Fouladi M, McGovern S, Kline C, Vitanza N, Lu G, Oster W, Allen JE, Khatua S. ONC201 in previously irradiated pediatric H3 K27M-mutant glioma or newly diagnosed DIPG. Annual Meeting of the Society of Clinical Oncology, 2020. e-Pub 2020.
- Baig M, Gibson A, Mohiuddin S, Triche L, Robusto L, Shirley E, Khatua S, Zaky W. Not the medication it’s the tubing system: A case of anaphylaxis to medicine delivery tubing system. Annual meeting of the International Society of Pediatric Neuro-Oncology, 2020. e-Pub 2020.
- Mohiuddin S, Baig M, Gibson A, Triche L, Robusto L, Shirley E, Khatua S, Zaky W. Incidence of proteinuria in NF2 patients receiving Avastin. Annual Meeting of the International Society of Pediatrics Neuro-Oncology, 2020. e-Pub 2020.
- Gupta S, Tian X, Wang J, Huse J, Rhines L, Sadighi Z, Zaky W, Tatsui C, Khatua S. Spinal Myxopapillary Ependymoma and Methylation-Profiling: The MD Anderson Cancer Center Experience. Annual meeting of the International Society of Pediatric Neuro-Oncology, 2020. e-Pub 2020.
- Baig M, Fuller G, Bingham R, Slopis J, Khatua S, Zaky W, Gupta S, Mork M, Sadighi Z. Treatment challenges in pediatric glioblastoma multiforme with concurrent somatic and germline NF1 mutations with germline mismatch repair mutations: two unique cases. Annual meeting of the International Society of Pediatric Neuro-Oncology, 2020. e-Pub 2020.
- Baig M, McGovern S, Khatua S, S, Zaky W. Salvage Proton Radiation Therapy and Outcome of Progressive and/or Relapsed Pediatric Medulloblastoma: Institutional Experience and Literature Review. Annual meeting of the International Society of Pediatric Neuro-Oncology, 2020. e-Pub 2020.
- Gardner SL, Koschmann CJ, Tarapore RS, Allen J, Zaky W, Odia Y, Hall MD, Daghistani D, Khatib Z, Aguilera D, MacDonald TJ, Fouladi M, McGovern S, Muellen S, Kline C, Vitanza N, Lu G, Allen JE, Khatua S. Safety and pharmacokinetics of ONC201 alone and in combination with radiation in pediatric H3 K27M-mutant diffuse midline gliomas. Annual meeting of the Society of Neuro-Oncology, 2020. e-Pub 2020.
- Baig M, Mohiuddin S, Johnson J, Lin R, Khatua S, Zaky W. Predictive and Prognostic Significance of Contrast Enhancement on MRI in Pediatric Low Grade Gliomas. Annual meeting of the International Society of Pediatric Neuro-Oncology, 2020. e-Pub 2020.
- Gardner S, Tarapore RS, Allen J, Zaky W, Odia Y, Hall M, Daghistani D, Khatib Z, Koschmann CJ, Aguilera D, MacDonald TJ, Fouladi M, McGovern S, Kline C, Vitanza N, Lu G, Merdinger K, Oster W, Allen JE, Khatua S. Phase I clinical trial of ONC201 in pediatric H3 K27M-mutant glioma or newly diagnosed DIPG. Annual meeting of the International Society of Pediatric Neuro-Oncology, 2020. e-Pub 2020.
- Baig M, Johnson J, Gupta S, Sadighi Z, Zaky W, Khatua S. A Phase I Study of Multi-Targeted Therapy in Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma. Annual meeting of the International Society of Pediatric Neuro-Oncology, Japan, 2020. e-Pub 2020.
- Gardner S, Allen J, Zaky W, Odia W, Daghistani D, Khatib Z, Koschmann C, Aguilera D, MacDonald TJ, Chi AS, Tarapore RS, Merdinger K, Oster W, Allen JE, Khatua S. ONC201 in previously-irradiated pediatric H3 K27M-mutant glioma. Annual Meeting of the American Society of Clinical Oncology, 2019. e-Pub 2019.
- Khatua S, Chandra J, Morrell MM, Meador HB, Sandberg DI, Weinberg J, Fuller G, Ketonen L, Johnson JM, Hess KR Zaky W. A phase I study of Suberoylanilide Hydroxamic Acid (SAHA) with Temsirolimus in children with newly diagnosed or progressive diffuse intrinsic pontine glioma (DIPG). American Association of Cancer Research Meeting, 2019. e-Pub 2019.
- McCall D, Baig M, McAleer M, Zaky W, Meador H, Ketonen L, Davis W, Slopis J, Sandberg D, Fuller G, Khatua S. Diffuse superficial cortical-leptomeningeal medulloblastoma mimicking leptomeningeal disease and correlative molecular biology. Pediatric Hematology / Oncology, 2019. e-Pub 2019.
- N Majd N, M Mastall M, K Hess K, G Fuller G, K Alfaro K, M Gule-Monroe M, J Huse J, S Khatua S, Rao, D Sandberg D, J Wefel J, D Yeboa D, W Zaky W, A Mahajan A, V Puduvalli V, D Suki D, S Weathers S, R Harrison R, J De Groot J, M Penas-Prado M. Characterization of Adult Medulloblastoma; a retrospective review of 200 patients at MD Anderson Cancer Center. SNO, 2019. e-Pub 2019.
- Majd N, Mastall M, Hess K, Fuller G, Alfaro K, Gule-Monroe M, Huse J, Khatua S, Rao G, Sandberg D, Wefel J, Yeboa D, Zaky W, Mahajan A, Puduvalli V, Suki D, Weathers S, Harrison R, De Groot J, Penas-Prado M. Characterization of Adult Medulloblastoma; a retrospective review of 200 patients at MD Anderson Cancer Center. Annual Meeting of the Society of Neuro-oncology, 2019. e-Pub 2019.
- Baig U, Khatua S, Zaky W, Sadighi Z. Unique concurrent association of somatic and germline NF1 mutations with germline mismatch repair mutations in pediatric glioblastoma multiforme. SNO, 2019. e-Pub 2019.
- Khatua S, Chandra J, Gopalakrishnan V, Ketonen L, Johnson MJ, Fuller G, Garcia Morrell MB, Meador H, Bolton K, Butterworth G, Mukheef F, Sadighi Z, Zaky W. Phase I trial of Temsirolimis and vorinostat in pediatric patient with DIPG. SNO, 2019. e-Pub 2019.
- A Sharma A, Y Lai Y, B Kennis B, S Shridaran S, T Dobson T, J Swaminathan J, S Khatua S, D Sandberg D, J Allen J, R Tarapore R, V Gopalakrishnan V, W Zaky W. Study of ONC201 in pre-clinical models of DIPG. SNO, 2019. e-Pub 2019.
- Gardner S, Tarapore RS, Allen J, Zaky W, Odia Y, Hall M, Daghistani D, Khatib Z, Koschmann CJ, Aguilera D, MacDonald TJ, Fouladi M, Merdinger K, Chiarella M, Oster W, Allen JE, Khatua S. Phase I clinical trial of ONC201 in pediatric H3 K27M-mutant glioma or newly diagnosed DIPG. SNO, 2019. e-Pub 2019.
- McCall D, Eterovic AK, Moss T, Baig M, Fuller G, Huse J, Sandberg D, Rytting M, Gill J, Chandra J, Khatua S, Shaw K, Meric-Bernstam F, Zaky W. Targeted Next Generation Sequencing Of Pediatric High Grade Glioma and Its Therapeutic Implications, MD Anderson Experience. SNO, 2019. e-Pub 2019.
- Baig M, Chan M, Johnson J, Sadighi Z, Ater J, Park M, Liu D, Roth M, Khatua S, Zaky W. American Pediatric Low-grade gliomas- clinical and radiological correlation. American Society of Pediatric Hematology/Oncology,, 2019. e-Pub 2019.
- Paulino AC, Grosshans D, Ludmir EB, McGovern SL, McAleer MF, Su J, Okcu MF, Khatua S, Zaky W, Mahajan A, Chintagumpala M. Preliminary Report of Secondary Malignant Neoplasm Incidence in Pediatric Patients Receiving Proton versus Photon Craniospinal Irradiation for Medulloblastoma. Annual Meeting of the American Society of Clinical Oncology, 2019. e-Pub 2019.
- Sridaharan S, Sharma A, Kennis B, Dobson T, Swanithan J, Haltom A, Lai Y, Khatua S, Sandberg DI, Allen J, Tarapore A, Hamanci A, Gopalakrishnan V, Zaky W. Study of ONC201 in Preclinical Models of DIPG. Annual Meeting of the Society of Neuro-oncology, 2019. e-Pub 2019.
- McCall D, Moss T, Eterovic AK, Baig M, Fuller G, Huse J, Sandberg D, Rytting M, Gill J, Chandra J, Khatua S, Shaw K, Meric-Bernstam F, Zaky W. Targeted Next Generation Sequencing of Pediatric High-Grade Glioma and its Therapeutic Implications, MD Anderson Cancer Center Experience. Annual Meeting of the American Society of Clinical Oncology, 2019. e-Pub 2019.
- Baig UM, Khatua S, Gupta S, Fuller G, Tran G, Mork M, Slopis J, Kamiya C, Zaky W, Sadighi Z. Unique concurrent association of somatic and germline NF1 mutations with germline mismatch repair mutations in pediatric glioblastoma multiforme. Annual Meeting of the American Society of Clinical Oncology, 2019. e-Pub 2019.
- Paulino AC, Grosshans D, Ludmir EB, McGovern SL, McAleer MF, Su J, M Fatih Okcu M, Khatua S, Zaky W, Mahajan A, Chintagumpala M. Preliminary Report of Secondary Malignant Neoplasm Incidence in Pediatric Patients Receiving Proton versus Photon Craniospinal Irradiation for Medulloblastoma. American Society for Radiation Oncology, 2019. e-Pub 2019.
- Trikha P, Nakkula R, Lamb M, Zaky W, Gopalakrishnan V, Khatua S, Lee D. Autologous locoregional NK cell immunotherapy for patients with recurrent 4th ventricular brain tumors. Natural Killer Cell Annual meeting, 2018. e-Pub 2018.
- Bailey CP, Romero MM, Han R, Larson JL, Becher OJ, Lee DA, Monje M, Gopalakrishnan V, Zaky W, Chandra J. LSD1 modulates NK cell immunotherapy through an onco-immunogenic gene signature in DIPG. International Symposium of Pediatric Neuro-oncology meeting, 2018. e-Pub 2018.
- Chi A, Gardner S, Arrillaga-Romany I, Wen PY, Batchelor T, Hall M, Odia Y, Zaky W, Khatua S, Shonka N, Khatib Z, Prabhu VV, Tarapore RS, Schalop L, Allen JE, Oster W, Minesh Mehta M. Integrated Clinical Experience with ONC201 in H3 K27M Glioma. International Symposium of Pediatric Neuro-oncology meeting, 2018. e-Pub 2018.
- Tarapore RS, Schalop L, Allen JE, Oster W, Mehta M. Integrated Clinical Experience with ONC201 in H3 K27M Glioma. International Symposium of Pediatric Neuro-oncology meeting, 2018. e-Pub 2018.
- Baig M, McCall D, Mohiuddin S, Patil S, Park M, Zaky W, Khatua S. Gangliogliomas in Children- MD Anderson Cancer Center Experience. International Symposium of Pediatric Neuro-Oncology meeting, 2018. e-Pub 2018.
- Chi AS, Romany IA, Gardner S, Wen PY, Batchelor TT, Hall M, Odia Y, Zaky W, Khatua S, McGovern S, Harrison R, DeGroot J, Sumrall A, Shonka N, Khatib Z, Karajannis M, Mueller S, Tarapore RS, Merdinger K, Schalop L, Allen JE, Oster W, Mehta M. Integrated clinical experience with ONC201 in previously-treated H3 K27M-mutant glioma patients. Society of Neuro-Oncology meeting, 2018. e-Pub 2018.
- Mastall M, Majd N, Fuller G, Gule-Monroe M, Huse J, Khatua S, Rao G, Sandberg D, Wefel J, Yeboa D, Zaky W, Mahajan A, Pudulvalli V, Suki D, Alfaro K, Weathers S, Harrison R, De Groot J, Penas-Prado M. Characterization of adult medulloblastoma patients at recurrence; retrospective review of the MD Anderson Cancer Center experience. Society of Neuro-Oncology meeting, 2018. e-Pub 2018.
- Batth IS, Zaky W, Chen SH, Huang W, Albert AC, Daw NC, Gill J, Li S, Khatua S. Pilot Study of Circulating Tumor Cells in Pediatric High Grade Brain Tumors. Society of Neuro-Oncology Annual Meeting (SNO), 2018. e-Pub 2018.
- Khatua S, Sandberg DI, Ketonen L, Rytting ME, Cooper LJ, Moyes J, Gopalakrishnan V, Johnson J, Lee D, Liu D, Zaky W. Phase I study of intraventricular infusions of autologous ex-vivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system. International Symposium of Pediatric Neuro-Oncology meeting, 2018. e-Pub 2018.
- Phadnis S, Patil S, Park M, Liu D, Wang WL, Wani KM, Calle S, Ketonen L, Zaky W, Khatua S. BRAF Mutations in Pediatric Gangliogliomas and the clinical significance – an MD Anderson Cancer Center experience. Society of Neuro-Oncology meeting, 2018. e-Pub 2018.
- Underiner R, Eltobgy M, Stanek JR, Michaud J, Zaky W, Bouffet E, Finlay JL, AbdelBaki MS. Meta-analysis of treatment modalities in metastatic atypical teratoid rhabdoid tumors in children. International Symposium of Pediatric Neuro-Oncology meeting, 2018. e-Pub 2018.
- Bravo-Alegria J, Maegawa S, Callegari K, Kennis B, Ma W, Brugmann W, Rao A, Lee D, Khatua S, Zaky W, Sandberg D, Goldman S, Gopalakrishnan V. Natural Killer Cell Immunotherapy for Diffuse Intrinsic Pontine Glioma. International Symposium of Pediatric Neuro-Oncology meeting, 2018. e-Pub 2018.
- Itzep N, Sridhar C, Gogia D, Zaky W, Meador H, Fuller G, Ketonen L, Khatua S. Embryonal Tumor with Multilayered Rosettes: The MD Anderson Cancer Center Experience. International Symposium of Pediatric Neuro-oncology meeting, 2018. e-Pub 2018.
- Khatua S, Gopalakrishnan V, Chandra J, Ketonen L, Sandberg D, Weinberg J, Fuller G, Hess KR, Slone N, Morrell M, Zaky W. A phase I study of Vorinostat and Temsirolimus in children with newly diagnosed or progressive diffuse intrinsic pontine glioma (DIPG). American Association of Cancer Research Annual meeting, 2017. e-Pub 2017.
- Phadnis S, Ketonen L, Fuller G, Khatua S, Zaky W. Diffuse Leptomeningeal Glioneuronal Tumor. GAP Conference, 2017. e-Pub 2017.
- Nehme G, Ketonen L, Khatua S, Zaky W. FBXW7 mutation in a child with medulloblastoma: A Case Report and Review of the Literature. GAP Conference, 2017. e-Pub 2017.
- Khatua S, Sandberg DI, Ketonen L, Rytting M, Cooper L, Moyes J, Gopalakrishnan V, Johnson J, Liu D, Zaky W. A Phase I study of Fourth Ventricular Infusions of Ex vivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system. American Association of Cancer Research Annual meeting, 2017. e-Pub 2017.
- Itzep N, Khatua S, Sridhar CD, Gogia B, Zaky W, Fuller G, Ketonen EL. Embryonal Tumor with Multilayered Rosettes: The MD Anderson Cancer Center Experience. ASPHO, 2017. e-Pub 2017.
- Zaky W, Patil SS, Liu D, Park M, Khatua S. Ganglioglioma management and outcome in children, adolescents, and young adults: Single institution experience and review of the literature. GAP Conference, 2017. e-Pub 2017.
- Phadnis S, Ketonen L, Fuller G, Khatua S, Zaky W. Diffuse Leptomeningeal Glioneuronal Tumor: distinctive entity without a current standard treatment. Case report and literature review. ASPHO, 2017. e-Pub 2017.
- Khatua S, Sandberg D, Ketonen L, Rytting M, Moyes J, Johnson J, Liu D, Gopalakrishnan V, Lee D, Zaky W. Phase I study of fourth ventricle infusions of autologous ex-vivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system. International Symposium in Pediatric Neuro-Oncology, 2016. e-Pub 2016.
- Tanaka R, Khatua S, Zaky W, Penas-Prado M, Shiao-Pei W, Subbiah V. Phase I study of BRAF inhibitor (Vemurafenib) in combination with the mTOR inhibitor (Everolimus) in BRAFv600E positive Pediatric and AYA brain tumors. American Society of Pediatric Hematology/Oncology Annual Meeting, 2016. e-Pub 2016.
- Brugmann WB, Laureano A, Hatcher R, Kennis BA, Khatua S, Zaky W, Sbardella G, Moyes J, Goldman S, Lulla R, Fangusaro J, Sandberg D, Silla L, Rajaram V, Hawkins C, Huang A, Cooper LNJ, Lee DA and Gopalakrishnan V. Identification of Molecular Mechanisms of NK resistance in Pediatric Posterior Fossa Tumors. International Symposium in Pediatric Neuro-Oncology, 2016. e-Pub 2016.
- Sandberg DI, Patel RP, Kerr M, Sitton CW, Ketonen LM, Hou P, Johnson JM, Shah MN, Fletcher S, Zaky W, Rytting ME, Khatua S. Phase-Contrast Cerebrospinal Fluid (CSF) Flow Magnetic Resonance Imaging (MRI) in Evaluating Distribution of Infused Agents from the Fourth Ventricle to the Total Spine. Neurosurgery Conference, 2016. e-Pub 2016.
- Gilbert A, Gokden M, Zaky W, Fuller CE, Ocal E, Leeds NE, Fuller GN. Extending the Neuroanatomic Territory of Diffuse Midline Glioma, K27M-Mutant Pineal Glioblastoma Multiforme. Neuropathology conference, 2016. e-Pub 2016.
- Zaky W, Sandberg DI, Ketonen L, Cooper LJ, Gopalakrishnan V, Lee D, Liu D, Khatua S. Phase I study of Fourth ventricle infusions of autologous ex vivo expanded NK cells in children with recurrent / refractory malignant posterior fossa tumors of the central nervous system. Society of Neurooncoogy Annual Meeting, 2015. e-Pub 2015.
- Khatua S, Zaky W, Rytting M, Weinberg J, Sandberg D, Mahajan A, Ketonen L, Johnson JM, Subbiah V. The Need for Multi-Targeted Therapy in Pediatric Brain Tumors with BRAF Mutation. Society for Neuro-Oncology SNO, 2015. e-Pub 2015.
- Khatua S, Sandberg DI, Ketonen L, Cooper LJ, Gopalakrishnan V, Lee D, Moyse J, Liu D, Zaky W. Phase I Study of Fourth Ventricle Infusions of Autologous Ex-vivo Expanded Natural Killer Cells in Children with Recurrent/Refractory Malignant Posterior Fossa Tumors of the Central Nervous System. Society for Neuro-Oncology (SNO), 2015. e-Pub 2015.
- Kannan G, Khatua S, Zaky W, Fuller G, Ketonen L. Papillary Glioneuronal Tumor:Case Report with Magnetic Resonance Findings. ISPNO, 2014. e-Pub 2014.
- Sandberg D, Khatua S, Maher O, Rytting M, Zaky W, Tomaras M, Kerr M, Ketonen L, Kundu U, Moore B, Yang G. Methotrexate Infusion Directly into the Fourth Ventricle for Treatment of Recurrent Malignant Fourth Ventricular Brain Tumors: A Pilot Clinical Trial. ASPHO, 2014. e-Pub 2014.
- Moonat H, Maher O, Almohammedsalim A, Khatua S, Zaky W. Infection Mimicking Malignancy. Report of two cases of abdominal tuberculosis and acute EBV infection simulating neoplasm. ASPHO, 2014. e-Pub 2014.
- Khatua S, Fuller G, Dasgupta S, Rytting M, Vats T, Zaky W. ETANTR, a rare biologically elusive tumor with clinical and radiographical heterigenity- MD Anderson Cancer Center Experience . Society of Neuro-Oncology, 2013. e-Pub 2013.
- Khatua S, Hou P, Wolff J, Hamilton J, Zaky W, Mahajan A, Ketonen L. Diffusion Tensor Imaging Confirms Efficacy of Re-irradiation Treatment in Pediatric Patients with Diffuse Intrinsic Pontine Glioma. Society of Neuro-Oncology, 2013. e-Pub 2013.
- Zaky W, Weinberg J, Fuller G, Ketonen L, McAleer M, Khatua S. Glioblastoma Multiforme in Siblings with Biallelic MSH6 Mutations: A Case Report and Review of the Literature. Society of Neuro-Oncology, 2013. e-Pub 2013.
- Khatua S, Sandberg D, Foresman L, Vats T, Dasgupta S, McAleer M, Zaky W. ICE as Salvage Therapy in Multiply Recurrent Intracranial Malignant Germ Cell Tumor. Society of Neuro-Oncology, 2013. e-Pub 2013.
- Zaky W, Olar A, Stewart J, Sandberg D, Foresman L, Ketonen L, Khatua S. Progressive Disseminated Supratentorial Primitive Neuroectodermal Tumor (SPNET Post-chemoradiation Treated with Combined Chemotherapy and Targeted Agent. Society of Neuro-Oncology, 2013. e-Pub 2013.
- Dhir N, Zaky W, Zomorodian T, Dhall G. Chronic myeloid leukemia as a secondary malignant neoplasm in a patient with medulloblastoma after treatment with chemotherapy and irradiation: A case report and review of literature. International Symposium on Pediatric Neuro-Oncology, 2012. e-Pub 2012.
- Zaky W, Bluml S, Grimm J, Wong, K, McComb JG, Gilles F, Finlay JL, Dhall G. Aggressive behavior of tectal gliomas in children: A report of two cases and review of literature. International Symposium on Pediatric Neuro-Oncology, 2012. e-Pub 2012.
- Zaky W, Bluml S, Grimm J, Wong, K, McComb JG, Gilles F, Finlay JL, Dhall G. Clear Cell Meningioma in Children: A Report of Two Cases With Description of Presenting Clinical Features, Treatment, and Patterns of Relapse. International Symposium on Pediatric Neuro-Oncology, 2012. e-Pub 2012.
- Zaky W, Kreimer S, Dagri J, Grimm JP, Bluml S, Britt B, Dhall G, Gilles F, Finlay JL. Transformation of Pediatric Non-Pilocytic Low Grade Astrocytomas to Malignant Gliomas: Preliminary Results of the Children’s Hospital Los Angeles (CHLA) Retrospective Review. Annual Meeting of the Society for Neuro-Oncology, 2011. e-Pub 2011.
- Bhatla T, Wang J, Morrison D, Zaky W, Raetz E, Carroll W. Vorinostat Reverses Relapse-Specific Drug Resistance Gene Expression Signatures In Childhood Acute Lymphoblastic Leukemia (ALL). ASPHO, 2010. e-Pub 2010.
- Zaky W, Chen Z, Meyer J, Bhatla T, Yang J, l E. IKAROS Deletion Leads to Chemotherapy Resistance in Pediatric Acute Lymphoblastic Leukemia. Pediatric Blood and Cancer 54(6):789, 2010. e-Pub 2010.
- Eterovic KA, Ezzedine N, Song P, Tang L, Mohammad M, Li S, Daw N, Meador H, Gill J, Khatua S, Hildebrandt M, Zaky W. A robust cell-free DNA (cfDNA) assay to detect mutations in plasma samples of pediatric high grade glioma patients despite of genomic DNA (gDNA) contamination. Society of Pediatric Neuro-Oncology Basic and Translational Research Conference 2019.
- Bath I, Zaky W, Daw NC, Khatua S, Albert A, Mahadeo KM, Khazal SJ, Rood S, Huang W, Chen D, Gill JB, Kleinerman E, Gorlick, Li S. Automated Capture and Analysis of Circulating Tumor Cells Across Different Types of Tumors in Pediatric Cancer Patients. American Association of Cancer Research Meeting, 2019.
Book Chapters
- Zaky, W. Central Nervous System Tumors in Childhood, 3116-3125.e1, 2024.
- Mohiuddin, S, Zaky, W, Cortes, JA. Overview of Pediatric Cancers, 491-497, 2023.
- Zaky W, Finlay J. Choroid Plexus Carcinoma. In: Chemotherapy in Brain Tumors. Springer publication, 2018.
- Zaky W, Khatua S, Ater J. Brain Tumors. In: Nelson Text Book of Pediatrics - 21st Edition. Elsevier publication, 2017.
- B Cuglievan B, W Zaky W, R Gorlick R, D Harrison D. Pediatric Cancers. In: The MD Anderson Manual of Medical Oncology. 4th Edition.
- Mohiuddin S, Zaky W, Cortes J. In: Perioperative/Peri-procedural care of the Pediatric patients with Cancer.
Patient Reviews
CV information above last modified July 22, 2026