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Wendy A. Woodward, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2000 Jefferson Medical College, Philadelphia, PA, MD, Medicine
2000 Thomas Jefferson University, Philadelphia, PA, PHD, Biochemistry and Molecular Biology
1993 Mount Holyoke College, S. Hadley, MA, BA, Cum Laude, High Honors, Chemistry

Postgraduate Training

9/2003-9/2004 Research Fellowship, Molecular Cellular Biology, Baylor College of Medicine, Houston, TX, Jeff M. Rosen, Ph.D.
7/2001-6/2005 Clinical Residency, Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, Thomas A. Buchholz, M.D
7/2000-7/2001 Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA, Glenn Eiger, M.D.

Board Certifications

6/2006 American Board of Radiology (Radiation Oncology)

Experience/Service

Other Appointments/Responsibilities

Research Director, Breast Radiation Oncology Section, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 8/2008-present

Honors and Awards

2008 RTOG Next Generation Investigator Award, Radiation Therapy Oncology Group
2005 Gilbert H. Fletcher Award, The University of Texas M. D. Anderson Cancer Center, Residency Research Award
2004 Roentgen Research Award, Radiological Society of North America
2003 Merit Award, American Society of Clinical Oncology
2003 Young Oncologist Essay Award, American Radium Society

Selected Publications

Peer-Reviewed Original Research Articles
1. Gilcrease MZ, Woodward WA, Nicolas MM, Corley LJ, Fuller GN, Esteva FJ, Tucker SL, Buchholz TA. Even Low-level HER2 Expression May be Associated With Worse Outcome in Node-positive Breast Cancer. Am J Surg Pathol 33(5):759-67, 5/1/2009. e-Pub 2/26/2009. PMID: 19252432.
2. Gilcrease MZ, Zhou X, Lu X, Woodward WA, Hall BE, Morrissey PJ. Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in brease cancer. Journal of Experimental and Clinical Cancer Research 28(67), 5/2009.
3. Vinh-Hung V, Truong P, Janni W, Nguyen NP, Vlastos G, Cserni G, Royve ME, Woodward WA, Promish D, Tai P, Soete G, Balmer-Majno S, Cutuli B, Storme G, Bouchardy C. The effect of adjuvant radiotherapy on mortality differs according to primary tumor location in women with node-positive breast cancer. Strahlenther Onkol 185(3):161-168, 3/2009. e-Pub 3/28/2009. PMID: 19330292.
4. Beadle BM, Woodward WA, Middleton LP, Tereffe W, Strom EA, Litton JK, Meric-Bernstam F, Theriault RL, Buchholz TA, Perkins GH. The impact of pregnancy on breast cancer outcomes in women </=35 years. Cancer 115(6):1174-84, 3/2009. PMID: 19204903.
5. Reed VK, Woodward WA, Zhang L, Strom EA, Perkins GH, Tereffe W, Oh JL, Yu TK, Bedrosian I, Whitman GJ, Buchholz TA, Dong L. Automatic Segmentation of Whole Breast Using Atlas Approach and Deformable Image Registration. Int J Radiat Oncol Biol Phys 73(5):1493-500, 9/17/2008. e-Pub 9/17/2008. PMID: 18804333.
6. Smith GL, Smith BD, Buchholz TA, Giordano SH, Garden AS, Woodward WA, Krumholz HM, Weber RS, Ang KK, Rosenthal DI. Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy. J Clin Oncol 26(31):5119-25, 8/25/2008. e-Pub 8/25/2008. PMID: 18725647.
7. Garg AK, Frija EK, Sun TL, Strom EA, Perkins GH, Oh JL, Yu TK, Woodward WA, Tereffe WA, Salehpour M, Buchholz TA. Effects of Variable Placement of Superior Tangential/Supraclavicular Match Line on Dosimetric Coverage of Level III Axilla/Axillary Apex in Patients Treated with Breast and Supraclavicular Radiotherapy. Int J Radiat Oncol Biol Phys 73(2):370-4, 8/2008. PMID: 18676090.
8. Beadle BM, Woodward WA, Tucker SL, Outlaw ED, Allen PK, Oh JL, Strom EA, Perkins GH, Tereffe W, Yu TK, Meric-Bernstam F, Litton JK, Buchholz TA. Ten-Year Recurrence Rates in Young Women With Breast Cancer by Locoregional Treatment Approach. Int J Radiat Oncol Biol Phys 73(3):734-44, 8/2008. e-Pub 8/2008. PMID: 18707822.
9. Truong PT, Vinh-Hung V, Cserni G, Woodward WA, Tai P, Vlastos G, Vlastos G. The number of positive nodes and the ratio of positive to excised nodes are significant predictors of survival in women with micrometastatic node-positive breast cancer. Eur J Cancer 44(12):1670-1677, 8/2008. PMID: 18595686.
10. Buchholz TA, Woodward WA, Duan Z, Fang S, Oh JL, Tereffe W, Strom EA, Perkins GH, Yu TK, Hunt KK, Meric-Bernstam F, Hortobagyi GN, Giordano SH. Radiation use and long-term survival in breast cancer patients with T1, T2 primary tumors and 1-3 positive axillary lymph nodes. Int J Radiat Oncol Biol Phys 71(4):1022-7, 7/15/2008. e-Pub 1/2008. PMID: 18234447.
11. Bristol IJ, Woodward WA, Strom EA, Cristofanilli M, Domain D, Singletary SE, Perkins GH, Oh JL, Yu TK, Terrefe W, Sahin AA, Hunt KK, Hortobagyi GN, Buchholz TA. Locoregional Treatment Outcomes After Multimodality Management Of Inflammatory Breast Cancer. Int J Radiat Oncol Biol Phys 72(2):474-84, 4/2008. e-Pub 4/24/2008. PMID: 18439768.
12. Smith GL, Smith BD, Giordano SH, Shih YT, Woodward WA, Strom EA, Perkins GH, Tereffe W, Yu TK, Buchholz TA. Risk of hypothyroidism in older breast cancer patients treated with radiation. Cancer 112(6):1371-1379, 3/2008.
13. Woodward WA, Durand JB, Tucker SL, Strom EA, Perkins GH, Oh JL, Arriaga L, Domain D, Buchholz TA. Prospective analysis of carotid flow in breast cancer patients treated with supraclavicular irradiation eight or more years prior to study: No increase in ipsilateral carotid stenosis after radiation. Cancer 112(2):268-273, 12/2007. PMID: 18000801.
14. Reed VK, Cavalcanti JL, Strom EA, Perkins GH, Oh JL, Tereffe W, Yu TK, Yeung H, Whitman GJ, Bedrosian I, Macapinlac HA, Buchholz TA, Woodward WA. Risk of subclinical micrometastatic disease in the supraclavicular nodal bed based on the anatomical distribution in patients with advanced breast cancer. Int J Radiat Oncol Biol Phys 71(2):435-40, 12/2007. PMID: 18164831.
15. Liengsawangwong R, Yu TK, Sun TL, Erasmus J, Perkins GH, Tereffe W, Oh JL, Woodward WA, Strom EA, Salehpour M, Buchholz TA. Treatment optimization using computed tomography-delineated targets should be used for supraclavicular irradiation for breast cancer. Int J Radiat Oncol Biol Phys 69(3):711-715, 12/2007. PMID: 17889264.
16. Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M, Marini FC. Tumor irradiation increases recruitment of circulating MSC into tumor microenvironment. Cancer Research 67(24):11687-11697, 12/2007.
17. Oh JL, Nguyen G, Whitman GH, Hunt KK, Yu TK, Woodward WA, Tereffe W, Strom EA, Perkins GH, Buchholz TA. Placement of radiopaque clips for tumor localization in patients undergoing neoadjuvant chemotherapy and breast conservation therapy. Cancer 110(11). e-Pub 10/2007. PMID: 17941034.
18. Garg AK, Oh JL, Oswald MJ, Huang E, Strom EA, Perkins GH, Woodward WA, Yu TK, Tereffe W, Meric-Bernstam F, Hahn K, Buchholz TA. Effect of postmastectomy radiotherapy in patients <35 years old with stage II-III breast cancer treated with doxorubicin-based neoadjuvant chemotherapy and mastectomy. Int J Radiat Oncol Biol Phys 69(5):1478-1483, 9/2007. PMID: 17855016.
19. McGuire SE, Gonzales-Angulo AM, Tucker SL, Kau SW, Yu TK, Strom EA, Oh J, Woodward WA, Tereffe W, Hunt KK, Kuerer HM, Sahin A, Hortobagyi GH, Buchholz TA. Post-mastectomy radiation improves the outcome of patients with stage III breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 68(4):1004-1009, 7/2007. PMID: 17418973.
20. Sher T, Henessy BT, Valero V, Brogio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzales-Angulo AM. Primary angiosarcomas of the breast. Cancer 110(1):173-178, 7/2007. PMID: 17541936.
21. Truong PT, Woodward WA, Thames HD, Ragaz J, Olivotto TA, Buchholz TA. The ratio of positive to excised nodes identifies high-risk subsets and reduces inter-institutional differences in locoregional recurrence risk estimates in breast cancer patients with 1-3 positive nodes: An analysis of prospective data from British Columbia and the M. D. Anderson Cancer Center. Int J Radiat Oncol Biol Phys 68(1):59-65, 5/2007. PMID: 17321065.
22. Huang EH, Strom EA, Valero V, Fornage B, Perkins GH, Oh JL, Yu TK, Tereffe W, Woodward WA, Hunt KK, Meric-Bernstam F, Sahin AA, Bedorsian I, Hortobagyi GN, Buchholz TA. Local-regional treatment outcomes for breast cancer patients with ipsilateral supraclaficular metastases at diagnosis. Int J Rad Oncol Biol Phys 67(2):490-496, 2/2007.
23. Chen MS, Woodward WA, Behbod F, Peddibhotla S, Alfaro M, Buchholz TA, Rosen JM. Wnt/B-catenin mediates radiation resistance of Sca1+ progenitors in immortalized mammary gland cell line. J Cell Science 120(3):468-477, 2007.
24. Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM. WTN/B-catenin mediates radiation resistance of mouse mammary progenitor cells. PNAS 104(2):618-623, 2007.
25. Woodward WA, Huang EH, McNeese MD, Perkins GH, Tucker SL, Strom EA, Middleton L, Gwyn K, Hortogabyi GN, Buchholz TA. African-American race is associated with a poorer overall survival rate for breast cancer patients treated with mastectomy and doxorubicin-based chemotherapy. Cancer 107(11):2662-2668, 12/2006.
26. Oh JL, Dryden MJ, Woodward WA, Yu TK, Tereffe W, Strom EA, Perkins GH, Middleton L, Hunt KK, Giordano SH, Oswald MJ, Domain D, Buchholz TA. Local-regional control of clinically diagnosed multifocal or multicentric breast cancer after neoadjuvant chemotherapy and local-regional therapy. J Clin Oncol 24(31):4971-4975, 11/2006.
27. Buchholz TA, Strom EA, Oswald Mj, Perkins GH, Oh J, Domain D, Yu Tk, Woodward WA, Tereffe W, Singletary SE, Thomas E, Buzdar AU, Hortogabyi GN, McNeese MD. Fifteen-year results of a randomized prospective trial of hyperfractionated chest wall irradiation versus once-daily chest wall irridation after chemotherapy and mastectomy for patients with locally advanced noninflammatory breast cancer. Int J Radiat Oncol Biol Phys 65(4):1155-1160, 7/2006.
28. Woodward WA, Vinh-Hung V, Ueno NT, Cheng YC, Royce M, Tai P, Vlastos G, Wallace AM, Hortobagyi GN, Nieto Y. Prognostic value of nodal ratios in node-positive breast cancer. J Clin Oncol 24:2910-6, 6/2006. PMID: 16782931.
29. Woodward WA, Giordano SH, Duan Z, Hortobagyi GN, Buchholz TA. Supraclavicular radiation for breast cancer does not increase the 10-year risk of stroke. Cancer 106(12):2556-2562, 6/2006.
30. Strom EA, Woodward WA, Katz A, Buchholz TA, Perkins GH, Jhingran A, theriault R, Singletary E, Sahin A, McNeese MD. Clinical investigation: regional nodal failure patterns in breast cancer patients treated with mastectomy without radiotherapy. Int J Radiat Oncol Biol Phys 63(5):1508-1513, 12/2005.
31. Woodward WA, Strom EA, McNeese MD, Perkins GH, Outlaw EL, Hortobagyi GN, Buzdar AU, Buchholz TA. Cardiovascular death and second non-breast cancer malignancy after postmastectomy radiation and doxorubicin-based chemotherapy. Int J Radiat Oncol Biol Phys 57:327-35, 10/2003. PMID: 12957242.
32. Woodward WA, Strom EA, Tucker SL, Katz A, McNeese MD, Perkins GH, Buzdar AU, Hortobagyi GN, Hunt KK, Sahin A, Meric F, Sneige N, Buchholz TA. Locoregional recurrence after doxorubicin-based chemotherapy and postmastectomy: Implications for breast cancer patients with early-stage disease and predictors for recurrence after postmastectomy radiation. Int J Radiat Oncol Biol Phys 57:336-44, 10/2003. PMID: 12957243.
33. Woodward WA, Strom EA, Tucker SL, McNeese MD, Perkins GH, Schechter NR, Singletary SE, Theriault RL, Hortobagyi GN, Hunt KK, Buchholz TA. Changes in the 2003 American Joint Committee on Cancer staging for breast cancer dramatically affect stage-specific survival. J Clin Oncol 21:3244-8, 9/2003. PMID: 12947058.
34. Woodward WA, Tuan RS. N-Cadherin expression and signaling in limb mesenchymal chondrogenesis: stimulation by poly-L-lysine. Dev Genet 24:178-87, 1999. PMID: 10079520.
35. Owen CS, Wahl ML, Leeper DB, Perry HD, Bobyock SB, Russell M, Woodward W. Accurate Whole-Spectrum Measurements of Intracellular pH and [Na+]. J Fluorescence 5:329-336,, 1995.

Invited Articles
1. Woodward WA, Bristow RG. Radiosensitivity of cancer-initiating cells and normal stem cells (or what the Heisenberg Uncertainly Principle has to do with Biology). Semin Radiat Oncol 19(2):87-95, 4/2009. PMID: 19249646.
2. Debeb BG, Xu W, Woodward WA. Radiation resistance of breast cancer stem cells: understanding the clinical framework. J Mammary Gland Biol Neoplasia 14(1). e-Pub 2/2009. PMID: 19252973.

Last updated: 9/15/2009