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Xiande Liu, PHD

Present Title & Affiliation

Primary Appointment

Instructor, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2005 Chinese Academy of Sciences, Shanghai, China, PHD, Biological Sciences
1997 Jiangsu Normal University, Jiangsu, China, BS, Biological Sciences

Postgraduate Training

9/2005-1/2011 Research Fellowship, Postdoctoral Fellowship, Baylor College of Medicine, Houston, TX

Experience/Service

Academic Appointments

Instructor, Department of Medicine Baylor College of Medicine, Houston, TX, 1/2011-3/2012
Postdoctoral Associate, Department of Medicine Baylor College of Medicine, Houston, TX, 9/2005-1/2011
Lab Manager, Department of Biology Jiangsu Normal University, Jiangsu, China, 9/1997-9/2000

Honors and Awards

2015 ASCO Merit Award
2014 Travel Grant, European Society for Medical Oncology
2005-2006 DiAo Award, Chinese Academy of Sciences
2004-2005 DiAo Award, Chinese Academy of Sciences
1997 Educational Scholarship, Hongshanshau Foundation

Selected Publications

Peer-Reviewed Original Research Articles

1. Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E. Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma. Oncogene 35(21):2687-97, 5/2016. e-Pub 9/2015. PMCID: PMC4791213.
2. DePavia A, Jonasch E, Liu XD. Autophagy degrades hypoxia inducible factors. Mol Cell Oncol 3(2):e1104428, 3/2016. e-Pub 3/2016. PMCID: PMC4905411.
3. German P, Bai S, Liu XD, Sun M, Zhou L, Kalra S, Zhang X, Minelli R, Scott KL, Mills GB, Jonasch E, Ding Z. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene. e-Pub 3/2016. PMID: 26973240.
4. Xu G, Jiang Y, Xiao Y, Liu XD, Yue F, Li W, Li X, He Y, Jiang X, Huang H, Chen Q, Jonasch E, Liu L. Fast clearance of lipid droplets through MAP1S-activated autophagy suppresses clear cell renal cell carcinomas and promotes patient survival. Oncotarget 7(5):6255-65, 2/2016. PMCID: PMC4868754.
5. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222, 2016. PMCID: PMC4835977.
6. Liu XD, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, Zhou L, Jonasch D, Zhang X, Conti CJ, Efstathiou E, Tannir NM, Eissa NT, Mills GB, Walker CL, Jonasch E. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene 34(19):2450-60, 5/2015. e-Pub 7/2014. PMCID: PMC4286517.
7. Liu X, Hoang A, Zhou L, Kalra S, Yetil A, Sun M, Ding Z, Zhang X, Bai S, German P, Tamboli P, Rao P, Karam JA, Wood CG, Matin SF, Zurita A, Bex A, Griffioen AW, Gao J, Sharma P, Tannir NM, Sircar K, Jonasch E. Resistance to anti-angiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma. Cancer Immunol Res. e-Pub 5/2015. PMID: 26014097.
8. Zhou X, Wang Y, Shan B, Han J, Zhu H, Lv Y, Fan X, Sang M, Liu XD, Liu W. The downregulation of miR-200c/141 promotes ZEB1/2 expression and gastric cancer progression. Med Oncol 32(1):428, 1/2015. e-Pub 12/2014. PMID: 25502084.
9. Ho TH, Liu XD, Huang Y, Warneke CL, Johnson MM, Hoang A, Tamboli P, Wang F, Jonasch E. The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma. BMC Cancer 15:304, 2015. e-Pub 4/2015. PMCID: PMC4406182.
10. Liu XD, Zhu H, DePavia A, Jonasch E. Dysregulation of HIF2a and autophagy in renal cell carcinoma. Molecular & Cellular Oncology 2(2):e965643, http://dx.doi.org/10.4161/23723548.2014.965643, 2014.
11. Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Research 74:3127-36, 2014.
12. Chen W, Ayala-Orozco C, Biswal NC, Perez-Torres C, Bartels M, Bardhan R, Stinnet G, Liu XD, Ji B, Deorukhkar A, Brown LV, Guha S, Pautler RG, Krishnan S, Halas NJ, Joshi A. Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells. Nanomedicine (Lond) 9(8):1209-22, 2014. e-Pub 9/2013. PMCID: PMC4051872.
13. Deeraksa A, Pan J, Sha Y, Liu XD, Eissa NT, Lin SH, Yu-Lee LY. Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis. Oncogene 32(24):2973-83, 6/13/2013. e-Pub 8/13/2012. PMCID: PMC3499666.
14. Xu Y, Fattaha EA, Liu XD, Jagannath C, Eissaa NT. Harnessing of TLR-mediated autophagy to combat mycobacteria in macrophages. Tuberculosis:S33-S37, 2013.
15. Liu XD, Ko S, Xu Y, Fattah EA, Xiang Q, Jagannath C, Ishii T, Komatsu M, Eissa NT. Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J Biol Chem 287(23):19687-98, 6/1/2012. e-Pub 4/19/2012. PMCID: PMC3366003.
16. Liu XD, Mazumdar T, Xu Y, Getzoff ED, Eissa NT. Identification of a flavin mononucleotide module residue critical for activity of inducible nitrite oxide synthase. J Immunol 183(9):5977-82, 11/2009. e-Pub 10/2009. PMID: 19828635.
17. Xu Y, Liu XD, Gong X, Eissa NT. Signaling pathway of autophagy associated with innate immunity. Autophagy 4(1):110-2, 1/2008. e-Pub 10/31/2007. PMID: 18059159.
18. Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27(1):135-44, 7/2007. e-Pub 7/19/2007. PMCID: PMC2680670.
19. Liu X, Shen Y. Salt shock induces state II transition of the photosynthetic apparatus in dark-adapted Dunaliella salina cells. Environmental and Experimental Botany 57(1–2):19-24, 8/2006.
20. Liu XD, Ma WM, Shen YG. State transition of the photosynthetic apparatus in plant. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao 32(2):127-32, 4/2006. PMID: 16622310.
21. Liu XD, Hu FH, Shen YG. Transient decrease of light-harvesting complex II phosphorylation level by hypoosmotic shock in dark-adapted Dunaliella salina. Acta Biochim Biophys Sin (Shanghai) 38(2):104-9, 2/2006. PMID: 16474901.
22. Liu XD, Shen YG. Changes in trans-thylakoid membrane proton motive force induced by treatments with red and far-red light in Dunaliella salina. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao 31(3):317-21, 6/2005. PMID: 15961908.
23. Liu XD, Shen YG. Salt-induced redox-independent phosphorylation of light harvesting chlorophyll a/b proteins in Dunaliella salina thylakoid membranes. Biochim Biophys Acta 1706(3):215-9, 2/17/2005. PMID: 15694349.
24. Liu XD, Shen YG. NaCl-induced phosphorylation of light harvesting chlorophyll a/b proteins in thylakoid membranes from the halotolerant green alga, Dunaliella salina. FEBS Lett 569(1-3):337-40, 7/2/2004. PMID: 15225658.
25. Liu X, Shen Y. Hypoosmotic shock induces a stateⅠtransition of photosynthetic apparatus in Dunaliella salina. Chinese Science Bulletin Vol. 49(No. 7):672—675, 1/2004.

Abstracts

1. Liu X, Hoang A, Zhou L, Kalra S, Yetil A, Sun M, Ding Z, Tamboli P, Rao P, Karam JA, Wood CG, Matin SF, Zurita AJ, Bex A, Griffioen AW, Gao J, Sharma P, Tannir NM, Sircar K, Jonasch E. Resistance to anti-angiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma. 2015 Genitourinary Cancers Symposium (#419), 2015.
2. Liu X, Hoang A, Zhou L, Kalra S, Sun M, Ding Z, Bai S, German P, Zhang X, Tamboli P, Rao P, Karam J, Wood C, Matin S, Tannir N, Sircar K, Jonasch E. Anti-angiogenic therapy induces T-lymphocyte infiltration associated with poor survival in metastatic renal cell carcinoma patients. Annals of Oncology 1060P, 2014.
3. Liu XD, Ko S, Xiang Q, Eissa TN. Alis Formation Is A Cytosolic Unfolded Protein Response To Inflammation And Endoplasmic Reticulum Stress. Am J Respir Crit Care Med (#A3219), http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A3219. e-Pub 5/2010.
4. Liu XD, Xu Y, Fung C, Dalu Z, Xiang Q, Jagannath C, Eissa NT. BCG Infection Induces P62-Dependent Autophagy-Independent Formation Of Dendritic Cell Aggresome-Like Structures. Am J Respir Crit Care Med (#A3222), http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A3222. e-Pub 5/2010.
5. Xu Y, Liu X, Eissa T. Harnessing Of TLR-mediated Autophagy To Eliminate Mycobacterium Tuberculosis From Macrophages. American Thoracic Society, 5/2010.

Grant & Contract Support

Title: The Role of Autophagy in Renal Carcinogenesis
Funding Source: MDACC Institutional Research Grant
Role: Co-Investigator
Principal Investigator: Eric Jonasch
Duration: 12/10/2014 - 12/9/2016
 
Title: Kidney Cancer Research Program Pilot Project
Funding Source: MDACC-Kidney MRP
Role: Investigator
Duration: 5/30/2013 - 6/1/2014

Last updated: 7/7/2016