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Xiao Ni, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Dermatology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Faculty, The University of Texas, Graduate School of Biomedical Sciences, Houston, TX

Research Interests

Skin immunology, tumor immunology, immunotherapy, dendritic cells, and T cells

Education & Training

Degree-Granting Education

1999 Peking Union Medical College, Beijing, China, PHD, Investigative Dermatology
1983 Nantong Medical College, Nantong, China, MD, Medicine

Postgraduate Training

2000-2003 Postdoctoral Fellow, Cutaenous T-cell Lymphoma, The University of Texas MD Anderson Cancer Center, Houston, TX
1989-1990 Clinical Fellowship, Dermapathology, Institution of Dermatology, The Chinese Academy of Medicine and Sciences, Nanjing, China
1984-1989 Clinical Residency, Dermatology, University of Nanjing - Affiliated Gulou Hospital, Nanjing, Jiangsu, China
1983-1984 Clinical Internship, internal medicine, University of Nanjing - Affiliated Gulou Hospital, Nanjing, China

Experience/Service

Institutional Committee Activities

Member, The Clinical Research Committee, 9/2008-8/2010

Professional Memberships

American Society of Hematology
Member, 2007-present
The Society of Investigative Dermatology
Member, 2002-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Ni X, Richmond H, Liao X, Decker W, Shiue L, Shpall E, Duvic M.. Induction of T-cell Responses against Cutaneous T-cell Lymphomas ex vivo by Autologous Dendritic Cells Transfected with Amplified Tumor RNA. J Invest Dermatol 128(11):2631-2639, 11/2008. e-Pub 5/15/2008. PMID: 18480841.
2. Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, Chiao JH, Reilly JF, Ricker JL, Richon VM, Frankel SR. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 109(1):31-9, 1/1/2007. PMID: 16960145.
3. Doherty SD, Ni X, Doherty CB, Jones D, Zhao X, Owen LB, Duvic M. Abnormal expression of interleukin-23 in mycosis fungoides/Sézary syndrome lesions. Arch Dermatol Res 298(7):353-6, 12/2006. PMID: 17021762.
4. Ni X, Zhang C, Talpur R, Duvic M. Resistance to activation-induced cell death and bystander cytotoxicity via the Fas/Fas ligand pathway are implicated in the pathogenesis of cutaneous T cell lymphomas. J Invest Dermatol 124(4):741-750, 2005. PMID: 15816832.
5. Zhang CL, Richon V, Ni X, Talpur R, Duvic M. Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. J Invest Dermatol 125(5):1045-52, 2005. PMID: 16297208.
6. Zhang C, Ni X, Konopleva M, Andreeff M, Duvic M. The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) induces apoptosis in Mycosis fungoides/Sézary syndrome cells. J Invest Dermatol 123(2):380-7, 8/2004. PMID: 15245439.
7. Apisarnthanarax N, Talpur R, Ward S, Ni X, Kim HW, Duvic M. Tazarotene 0.1% Gel for Refractory Mycosis Fungoides Lesions: An Open-label Pilot Study. J Am Acad Dermatol 50(5):600-607, 2004. PMID: 15034511.
8. Duvic M, Ni X, Talpur R, Herne K, Schulz C, Sui D, Ward S, Joseph A, Hazarika P. Tazarotene induced gene-3 is suppressed in basal cell carcinomas and reversed in vivo by tazarotene application. J Invest Dermatol 121(4):902-9, 10/2003. PMID: 14632211.
9. Zhang CL, Hazarika P, Ni X, Weidner DA, Duvic M. Induction of Apoptosis by Bexarotene in Cutaneous T-Cell Lymphoma Cells: Relevance to Mechanism of therapeutic Action. Clin Cancer Res 8(5):1234-1240, 2002. PMID: 12006543.
10. Ni X, Hazarika P, Zhang C, Talpur R, Duvic M. Fas ligand expression by neoplastic T- lymphocytes mediates elimination of CD8+ cytotoxic T lymphocytes in mycosis fungoides: a potential mechanism of tumor immune escape? . Clin Cancer Res 7(9):2682-92, 9/2001. PMID: 11555580.
11. Ni X, Sun JF. Methygreen-Pyronin staining for apoptotic cells in psoriatic Lesions. Journal of Clinical Dermatology 29(6):334-336, 2000.
12. Ni X, Sun JF, Zeng XS,Sang HG, Li AM, Ye GY. The excessive prolifereation and apoptosis are correlated with the abnormal expression of c-myc, P53 and bcl-2 in psoriatic lesions. Chinese Journal of Dermatology 33(4):240-242, 2000.
13. Ni X, Sun JF. Improved diagnosis accuracy with pathological reports for the suspected psoriasis. Chinese Journal of Dermatology and Venereology 13(2):75-76, 1999.
14. Ni X, Jiang YQ, Sun JF. Apoptosis in the development of Pilomatricoma. Chinese Journal of Dermatology 31(6):386-387, 1998.
15. Ni X, Yang HP, Sun JF. Excessive proliferation and apoptosis in both keratinocytes and infiltrating lymphocytes of psoriatic lesions. Chinese Journal of Dermatology 31(2):95-96, 1998.
16. Yang HP, Ni X, Sun JF. Psoriasis arthropathica: analysis of 26 cases. Chinese Journal of Dermatology 31(2):114- 115, 1998.
17. Ni X. A case study: Piebaldism and the pedigree analysis. Journal of Clinical Dermatology 24(1):50, 1995.
18. Ni X, Chen ZG, Zhu WW. Epidermal-grafting for the patient with piebaldism. Chinese Journal of Dermatology 28(4):261, 1995.
19. Ni X, Fang Y, Zhu WW. A clinical trial of Germanium Huangqi for psoriasis vulgaris. Chinese Journal of Dermatology 27(6):377-378, 1994.
20. Ni X, Lu ML, Li FQ. Clinical efficacy of chinese medicine herbs for summer dermatitis. Journal of Clinical Dermatology 23(1):46, 1994.
21. Ni X. Two cases of anhidrotic ectodermal dysplasia. Chinese Journal of Dermatology 27(3):183, 1994.
22. Ni X, Li FQ. Analysis of non-papillomatous hyperplastic lesions in genitalia. Jiangsu Medical Journal 19:282, 1993.
23. Gu JG, Gu XJ, Ni X. Clinical efficacy of enoxacin for skin infectious dieseases. Chinese Journal of Antibiotics 18(6):465-468, 1993.
24. Ni X, Li FQ. A case study: pseudo-acanthosis nigricans. Chinese Journal of Dermatology 25(5):348, 1992.
25. Ni X, Li FQ, Liu JH. A case study: cutaneous T cell lymphoma manifesting lethal midline granuloma. Chinese Journal of Dermatology 24(4):275-276, 1991.
26. Xiao Ni, Meghali Goswami, Alexis Dougherty, Lisa Shiue, and Madeleine Duvic. Increased Twist expression in advanced stage of cutaneous T-cell lymphoma. Journal of Cutaneous Pathology. Submitted.
27. Chung JS, Shiue L, Dougherty A, Ni X, Duvic M, Cruz, Jr. P, Ariizumi K,. Overexpression of Syndecan-4 by Cutaneous T Cell Lymphoma Is a Potentially Useful Target for Therapy. Journal of Clinical Investigation. Submitted.

Invited Articles
1. Ni X, Sun JF. In situ polymerase chain reaction and its applications in the dermatology. Foreign Medical Sciences 23(5):279-282, 1997.
2. Ni X, Sun JF. Updates of the molecular biological studies on psoriasis. Foreign Medical Sciences 23(2):85-87, 1997.

Abstracts
1. Ni X, Kim Y, Goswami M, et al. THE EXPRESSION OF CCR4 IN PTCL/CTCL SKIN LESIONS AND ITS CORRELATION WITH THE SKIN RESPONSE TO KW-0761. First World Congress of Cutaneous Lymphomas, 9/2010.
2. LH Shiue, M Goswami, A Alousi, C Hosing, M Duvic, X Ni. Effect of extracorporeal photopheresis on dendritic cell populations in patients with Sézary syndrome and graft versus host disease. Journal of Investigative Dermatology 130(S1):S119, 4/2010.
3. Ni X, Goswami M, Shiue LH, Dougherty A , and Duvic M. Increased Twist expression in advanced stage. Journal of Investigative Dermatology 130(S1), 4/2010.
4. LH Shiue, E Ahkus, P Arias-Mendoza, M Duvic, X Ni. Increased levels of CD4+25high regulatory T cells in patients with cutaneous T-cell lymphoma after extracorporeal photopheresis. Journal of Investigative Dermatology 129(S1):S46, 4/2009.
5. Alexis Dougherty, Lisa Shiue, Roland Bassett, Madeleine Duvic, Victor Prieto, and Xiao Ni. Increased Syndecan-4 expression in malignant T -lymphocytes is associated with progression in Mycosis Fungoides. Journal of Investigative Dermatology 129(S1):S45, 4/2009.
6. Xiao Ni, Lisa Shiue, Paola Arias-Mendoza, Erin Aakhus, Chitra Hosing, and Madeleine Duvic. Foxp3 Expression is Induced in Peripheral Blood Mononuclear Cells from Patients with CTCL and GVHD after Extrocorporeal Photopheresis. Blood 112::2912, 11/2008.
7. Ni X,Zhou WH,Shiue L, Aakhus E, Duvic M. A novel approach to study tumor-specific CD8+ cytotoxic T lymphocyte in cutaneous T-cell lymphoma patients treated with extracorporeal photopheresis. J Invest Dermatol 129, 2008.
8. Ni X, Kelly C, Talpur R, Zhang C, Breuer-Mc-Ham J, Richon V, Duvic M. Anti-angiogenic effect of vorinostar (suberoylanilide hydroxamic acid, SAHA), a histone deacetylase inhibitor, in CTCL lesions. J Invest Dermatol. 126:2, 2006.
9. Ni X, Liao XS, Segall H, Zhang CL, Shpall E, Duvic M. Apoptotic cells and tumor cell lysate pulsed CD14+monocyte-derived dendritic cells from cutaneous T-cell lymphoma mature and induce allogenic T-cell proliferation in vitro. J Invest Dermatol 122(3):A121, 2004.
10. Ni X, Talpur R, Herne K, Schulz C, Sui D, Ward S, Hazarika P, Josephs A, Duvic M. Tazarotene induced gene-3 is suppressed in basal cell carcinomas and upregulated by tazarotene in vivo. J Invest Dermatol 121(1):191, 2003.
11. Ni X, Zhang CL, Hazarika P, Duvic M. Functional Fas ligand is expressed in human cutaneous T cell lymphoma cells and inhibited by Bexarotene. J Invest Dermatol 119(1):217, 2002.
12. Hazarika P, Geoge S, Prieto V, Ni X, Bar-Eli MM, Duvic M. Over-expression of a novel caveolae associated protein, Flotillin-2, is associated with melanoma progression. J Invest Dermatol 119(1):223, 2002.

Book Chapters
1. Ni X, Sun J, Liu J. History of Dermatopathology in China. In: Chinese Modern Scientific Encyclopedia. Scientific Publishing House, 2000.
2. Ni X. Benign and Malignant epidermal tumors. In: Atlas of Dermatology and Venereology. the People's Medical Publishing House, 337-354, 1998.

Last updated: 11/19/2010