Yan Xia, Ph.D.
Department of Neuro-Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Instructor, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2000 | Umeå University, Umeå, SWE, PHD, Medical Microbiology |
| 1991 | Nanjing University, Nanjing, CHN, MBA, Molecular Biology |
| 1988 | Nanjing University, Nanjing, CHN, BS, Biochemistry |
Postgraduate Training
| 2001-2004 | Post-doctoral fellow, Molecular and Cellular Biology, The Salk Institute for Biological Studies, La Jolla, CA |
Experience & Service
Academic Appointments
Research Associate, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2004 - 2007
Honors & Awards
| 2007 | Nycomed GmbH Outstanding Research Publication Award, The University of Texas M. D. Anderson Cancer Center |
| 2007 | The A. Lavoy Moore Endowed Fund Award, The University of Texas M. D. Anderson Cancer Center |
| 2002 | California Breast Cancer Research Program Postdoctoral Fellowship, The Salk Institute for Biological Studies |
| 1996 | Ph.D. Fellowship "Doktorandtjanst", Umeå University, Sweden |
Selected Publications
Peer-Reviewed Articles
- Chen P, Hsu WH, Han J, Xia Y, DePinho RA.. Cancer Stemness Meets Immunity: From Mechanism to Therapy. Cell Rep 34(1):108597, 2021. PMID: 33406434.
- Liu R, Lee JH, Li J, Yu R, Tan L, Xia Y, Zheng Y, Bian XL, Lorenzi PL, Chen Q, Lu Z.. Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. Mol Cell 81(13):2722-2735, 2021. e-Pub 2021. PMID: 34077757.
- Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z.. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature 580(7804):530-535, 2020. e-Pub 2020. PMID: 32322062.
- Li X, Qian X, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, DePinho RA, Lu Z.. Programmable base editing of mutated TERT promoter inhibits brain tumour growth. Nat Cell Biol 22(3):282-288, 2020. PMID: 32066906.
- Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z.. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Mol Cell 76(6):885-895, 2019. PMID: 31629659.
- Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L, Zheng Y, Zhao D, Zhang C, Lorenzi PL, You Y, Jiang BH, Jiang T, Li H, Lu Z.. PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1. Mol Cell 76(3):516-527, 2019. PMID: 31492635.
- Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, Lu Z.. Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Mol Cell 72(4):650-660, 2018. PMID: 30392930.
- Wang Y, Xia Y, Lu Z.. Metabolic features of cancer cells. Cancer Commun (Lond) 38(1):65, 2018. PMID: 30376896.
- Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GB, Jiang T, Lu Z.. EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Mol Cell 70(2):197-210, 2018. PMID: 29677490.
- Qian X, Li X, Tan L, Lee JH, Xia Y, Cai Q, Zheng Y, Wang H, Lorenzi PL, Lu Z.. Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress. Cancer Discov 8(1):94-107, 2018. PMID: 29074724.
- Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z.. KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase. Nature 552(7684):273-277, 2017. PMID: 29211711.
- Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, Li W, Lyu J, Rao G, Zhang X, Qian CN, Rozen SG, Jiang T, Lu Z.. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell 66(5):684-697, 2017. PMID: 28552616.
- Liang J, Cao R, Zhang Y, Xia Y, Zheng Y, Li X, Wang L, Yang W, Lu Z. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nat Commun 7:12431, 2016. e-Pub 2016. PMID: 27485204.
- Li X, Jiang Y, Meisenhelder J, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, Lu Z. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Mol Cell 61(5):705-719, 2016. PMID: 26942675.
- Ji H, Lee JH, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z. EGFR phosphorylates FAM129B to promote Ras activation. Proc Natl Acad Sci U S A 113(3):644-9, 2016. e-Pub 2015. PMID: 26721396.
- Zheng Y, Li X, Qian X, Wang Y, Lee JH, Xia Y, Hawke DH, Zhang G, Lyu J, Lu Z. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nat Cell Biol 17(10):1348-55, 2015. e-Pub 2015. PMID: 26280537.
- Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol 17(9):1158-68, 2015. e-Pub 2015. PMID: 26237645.
- Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z.. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell 53(1):75-87, 2014. PMID: 24316223.
- Xia Y, Yang W, Bu W, Ji H, Zhao X, Zheng Y, Lin X, Li Y, Lu Z.. Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. J Biol Chem 288(27):19321-9, 2013. PMID: 23678002.
- Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z.. EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell 48(5):771-84, 2012. e-Pub 2012. PMID: 23123196.
- Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z.. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biology 14(12):1295-304, 2012. PMID: 23178880.
- Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z.. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 2012. PMID: 22901803.
- Yang W, Xia Y, Zheng Y, Liang J, Huang W, Gao X, Aldape K, and Lu Z.. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature 480(7375):118-22, 2011. PMID: 22056988.
- Chen H, Xia Y, Fang D, Hawke D, Lu Z. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol 29(13):3657-64, 2009. e-Pub 2009. PMID: 19380486.
- Zheng Y, Xia Y, Hawke D, Halle M, Tremblay M, Gao X, Xie K, He J, and Lu Z.. FAK phosphorylation by ERK primes Ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell 35(1):11-25, 2009. PMID: 19595712.
- Lindberg S, Xia Y, Sonden B, Goransson M, Hacker J, and Eric B.. Regulatory interactions among adhesin gene systems of uropathogenic Escherichia coli. Infection and Immunity 76(2):771-80, 2007. e-Pub 2007. PMID: 18039830.
- Xia Y, Wang J, Xu S, Johnson GL, Hunter T, Lu Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol 27(2):510-7, 2007. e-Pub 2006. PMID: 17101801.
- Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z.. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem, 2007. PMID: 17287208.
- Xia Y, Wang J, Liu TJ, Yung WKA, Hunter T, and Lu Z.. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol Cell 25(2):219-232, 2007. PMID: 17244530.
- Xia Y, Suzuki H, Borevitz J, Blount J, Guo Z, Patel K, Dixon RA, Lamb C.. An extracellular aspartic protease functions in Arabidopsis disease resistance signaling. EMBO J 23(4):980-8, 2004. PMID: 14765119.
- Xia Y, Pao GM, Verma IM, and Hung T.. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem, 2003. PMID: 12431996.
- Xia Y, Gally D, Forsman-Semb K, and Uhlin DE.. Regulatory cross-talk between adhesin operons in Escherichia coli: inhibition of type 1 fimbriae expression by the PapB protein. EMBO J 19(7):1450-1457, 2000. PMID: 10747013.
- Xia Y, Uhlin BE.. Mutational analysis of the PapB transcriptional regulator in Escherichia coli. Regions important for DNA binding and oligomerization. J Biol Chem 274(28):19723-30, 1999. PMID: 10391913.
- Xia Y, Forsman K, Jass J, Uhlin BE. Oligomeric interaction of the PapB transcriptional regulator with the upstream activating region of pili adhesin gene promoters in Escherichia coli. Mol Microbiol 30(3):513-23, 1998. PMID: 9822817.
Book Chapters
- Xia Y, Forsman-Semb K, Jass J, and Uhlin BE.. Structural and functional studies of the fimbrial adhesin gene regulator PapB from uropathogenic Escherichia coli.. In: Genes and Proteins Underlying Microbial Urinary Tract Virulence, Part of Series: Advances in Experimental Medicine and Biology. Kluwer Academic/Plenum Publishers: New York, 123-6, 2000.
- Uhlin BE, Balsalobre C, Forsman-Semb K, Göransson M, Jass J, Johansson J, Naureckiene S, Sondén B, Urbonaviciene J, and Xia Y. Control mechanisms in the Pap-pili system. In: Genes and Proteins Underlying Microbial Urinary Tract Virulence, Part of Series: Advances in Experimental Medicine and Biology. Kluwer Academic Publishers: New York, 113-118, 2000.
Grant & Contract Support
| Title: | Identification of collateral lethal and synthetic lethal targets in pancreatic and colorectal cancers |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Key Personnel |
Patient Reviews
CV information above last modified July 17, 2023