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Ying Yuan, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Dept of Statistics, Rice University, Houston, TX
Associate member, The University of Texas Graduate School of Biometrical Science, Houston, TX

Research Interests

  • Bayesian clinical trial design
  • Statistical analysis of missing data and longitudinal data
  • Mediation analysis
  • Survey sampling

More about my research can be found at http://odin.mdacc.tmc.edu/~yyuan

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street
Unit Number: 1411
Houston, TX 77030-4009
Room Number: FCT4.6032
Phone: 713-563-4271
Fax: 713-563-4243

Education & Training

Degree-Granting Education

2005 University of Michigan, Ann Arbor, MI, PHD, Biostatistics
2000 Brandeis University, Waltham, MA, MS, Biochemistry

Professional Memberships

American Statistical Association, Eastern North American Region/International Biometric Society
Member, 2005-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Yuan Y, Johnson VE. Goodness-of-Fit diagnostics for Bayesian Hierarchical Models. Biometrics 68(1):156-64, 3/2012. e-Pub 11/2011. PMCID: PMC3276744.
2. Koul D, Fu J, Shen R, LaFortune TA, Wang S, Tiao N, Kim YW, Liu JL, Ramnarian D, Yuan Y, Garcia-Echevrria C, Maira SM, Yung WK. Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells. Clin Cancer Res 18(1):184-95, 1/1/2012. e-Pub 11/7/2011. PMID: 22065080.
3. Yuan Y, Thall PF, Wolff JE. Estimating progression-free survival in paediatric brain tumour patients when some progression statuses are unknown. J R Stat Soc Ser C Appl Stat 61(1):135-149, 1/1/2012. PMCID: PMC3298417.
4. Schover LR, Canada A, Yuan Y, Sui D, Neese L, Jenkins R, Rhodes MM. A randomized trial of internet-based versus traditional sexual counseling for couples after localized prostate cancer treatment. Cancer 118:500-509, 2012.
5. Huo L, Yuan Y and Yin G. Dose Finding in Drug Combinations with Discrete and Continuous Doses. Bayesian Analysis 7:235-252, 2012.
6. Yuan Y, Thall P. and Wolff J. Estimating progression-free survival when the progression status of some subjects is unknown. Journal of the Royal Statistical Society: Series C 61:135-149, 2012.
7. Yao J, Zhao Q, Yuan Y, Zhang L, Liu X, Yung WK, Weinstein JN. Identification of common prognostic gene expression signatures with biological meanings from microarray gene expression datasets. PLoS One 7(9):e45894, 2012. e-Pub 9/21/2012. PMCID: PMC3448701.
8. Zhang G. and Yuan, Y. Modeling Longitudinal Dyadic Data with Nonignorable Dropout with Application to a Breast Cancer Study. Annals of Applied Statistics 6:753-771, 2012.
9. Younes A, Oki Y, Copeland AR, Feng L, Yuan Y, Chuang H, Macapinlac H, Fanale MA, Fayad L, McLaughlin P, Pro B, Hagemesiter F, Romaguera J, Samaiego F, Dabaja B and Rodriquez MA. Phase II Study of Rituximab plus ABVD in Patients with Newly Diagnosed Classical Hodgkin Lymphoma. Blood 119:4123-4128, 2012.
10. Fingeret MC,Yuan Y, Urbauer D, Weston J, Weber R. The nature and extent of body image concerns in patients with facial cancer. Psycho-oncology 21:836-844, 2012.
11. Yuan Y, Yin G. Dose-response curve estimation: A semiparametric mixture approach. Biometrics 67(4):1543-54, 12/2011. e-Pub 5/31/2011. PMID: 21627631.
12. Yuan Y, Huang X, Liu S. A Bayesian response-adaptive covariate-balanced randomization design with application to a leukemia clinical trial. Stat Med 30(11):1218-29, 5/20/2011. e-Pub 3/22/2011. PMCID: PMC3086983.
13. Lei X, Yuan Y, Yin G. Bayesian phase II adaptive randomization by jointly modeling time-to-event efficacy and binary toxicity. Lifetime Data Anal 17(1):156-74, 1/2011. e-Pub 4/3/2010. PMID: 20364321.
14. Yuan Y. and Yin G. Bayesian phase I/II drug-combination trial design in oncology. The Annals of Applied Statistics 5:924-942, 2011.
15. Le-Petross HT, Whitman GJ, Atchely DP, Yuan Y, Gutierrez-Barrera A, Berry D, Hortobagyi GN, and Arun BK. Effectiveness of alternating mammography and magnetic resonance imaging for screening women at high risk of breast cancer. Cancer 117:3900-3907, 2011.
16. Carmack, C.L., Basen-Engquist, K., Yuan, Y., Rodriguez-Bigas, M., Wolff, R., Barker T., Pennebaker J. Feasibility of an expressive-disclosure group intervention for post-treatment colorectal cancer patients: Results of the Healthy Expressions study. Cancer 117:4993-5002, 2011.
17. Yuan, Y. and Yin, G. Hybrid Bayes factor design in phase I oncology clinical trials. Statistics in Medicine 30:2098-2108, 2011.
18. Yuan Y and Yin G. On adaptive randomization: is it useful? JCO 29:e390-e392, 2011.
19. Yuan, Y. and Yin, G. Robust EM continual reassessment method in oncology dose finding. JASA 106:818-831, 2011.
20. Yin G, Ma Y, Liang F and Yuan Y. Stochastic generalized method of moments. Journal of Computational and Graphical Statistics 20:714-727, 2011.
21. Yuan Y, Yin G. Bayesian quantile regression for longitudinal studies with nonignorable missing data. Biometrics 66:105-114, 2010. PMID: 19459836.
22. Yin G and Yuan Y. Rejoinder to the correspondence of Gasparini, Bailey and Neuenschwander on Bayesian dose finding in oncology for drug combinations by copula regression. Journal of the Royal Statistical Society Series C:544-546, 2010.
23. Yuan Y, MacKinnon DP. Bayesian mediation analysis. Psychol Methods 14(4):301-22, 12/2009. PMCID: PMC2885293.
24. Kiserud CE, Schover LR, Dahl AA, Fosså A, Bjøro T, Loge JH, Holte H, Yuan Y, Fosså SD. Do male lymphoma survivors have impaired sexual function? J Clin Oncol 27(35):6019-26, 12/2009. e-Pub 10/2009. PMID: 19858388.
25. Yin G. and Yuan Y. Bayesian model averaging continual reassessment method in phase I clinical trials. Journal of the American Statistical Association 104(487):954-968, 9/2009.
26. Yuan Y, Little RJ. Meta-analysis of studies with missing data. Biometrics 65(2):487-96, 6/2009. e-Pub 5/18/2008. PMID: 18565168.
27. Yuan Y, Little RJ. Mixed-effect hybrid models for longitudinal data with nonignorable dropout. Biometrics 65(2):478-86, 6/2009. e-Pub 8/2008. PMID: 18759842.
28. Song P.X., Li M, and Yuan Y. Joint regression analysis of correlated data using Gaussian copulas. Biometrics 65(1):60-68, 3/2009. e-Pub 5/2008. PMID: 18510653.
29. Yin G. and Yuan Y. Bayesian dose-finding in oncology for drug combinations by copula regression. Journal of the Royal Statistical Society: Series C 58:211-224, 2009.
30. Yuan Y. and Yin, G. Bayesian dose-finding by jointly modeling toxicity and efficacy as time-to-event outcomes. Journal of the Royal Statistical Society: Series C 58:719-736, 2009.
31. Yuan Y, Yin G. Sequential continual reassessment method for two-dimensional dose finding. Stat Med 27(27):5664-78, 11/29/2008. PMID: 18618901.
32. Yin G, Yuan Y. A latent contingency table approach to dose finding for combinations of two agents. Biometrics. e-Pub 8/2008. PMID: 18759848.
33. Yuan Y, and Johnson VE. Bayesian hypothesis tests using nonparametric statistics. Statistica Sinica 18:1185-1200, 2008. PMID: Not in PubMed.
34. Yuan Y, and Little R.J.A. Model-based inference for two-stage cluster samples subject to nonignorable item nonresponse. Journal of Official Statistics 24(2):193-211, 2008. PMID: Not in PubMed.
35. Yuan Y, Little RJ. Parametric and semiparametric model-based estimates of the finite population mean for two-stage cluster samples with item nonresponse. Biometrics 63(4):1172-80, 12/2007. e-Pub 5/8/2007. PMID: 17489967.
36. Kolker JL, Yuan Y, Burt BA, Sandretto AM, Sohn W, Lang SW, Ismail AI. Dental caries and dietary patterns in low-income African American children. Pediatr Dent 29(6):457-64, Nov-Dec, 11/2007. PMID: 18254414.
37. Johnson V, Yuan Y. Comments on 'An exploratory test for an excess of significant findings' by JPA loannidis and TA Trikalinos. Clin Trials 4(3):254-5; discussion 256-7, 2007. PMID: 17715250.
38. Yuan Y, Little RJA. Model-based estimates of the finite population mean for two-stage cluster samples with unit non-response. Journal of the Royal Statistical Society:Series C 56(1):79-97, 2007. e-Pub 1/2007. PMID: Not in PubMed.
39. Zhou J, Yuan Y, Reynolds R, Raber S, Li Y. Cost-efficient higher-order crossover designs in comparative bioavailability studies. Clin Pharmacokinet 45(6):623-32, 2006. PMID: 16719543.
40. Burt BA, Kolker JL, Sandretto AM, Yuan Y, Sohn W, Ismail AI. Dietary patterns related to caries in a low-income adult population. Caries Res 40(6):473-80, 2006. PMCID: PMC1626651.
41. Yuan Y, Zhou J. Cost-efficient higher-order crossover designs for two-treatment clinical trials. Pharmaceutical Statistics 4(4):245-252, 2005. e-Pub 11/2005. PMID: Not in PubMed.
42. Zhou J, He Y, Yuan Y. Comparison of Schuirmann's two one-sided tests with nonparametric two one-sided tests for non-normal data in clinical pharmacokinetic drug-drug interaction studies. Online Journal of Pharmacology and Pharmacokinetics 2:33-43, 2004. PMID: Not in PubMed.
43. Yuan Y, Wang ZH, Tang Jian-Guo. Intra-a chain disulphide bond forms first during insulin precursor folding. Biochemistry Journal 343:139-44, 1999.

Book Chapters

1. Yin, G. and Yuan, Y. Bayesian approach for adaptive design. In: Handbook of Adaptive Designs in Pharmaceutical and Clinical Development, 2010.

Letters to the Editor

1. Song PX, Li M and Yuan Y. Rejoinder to Joint regression analysis for discrete Longitudinal data by Madsen and Fang. Biometrics 67:1175-1176, 2011.
2. Yin, G. and Yuan, Y. Rejoinder to the correspondence of Gasparini, Bailey and Neuenschwander on ``Bayesian dose finding in oncology for drug combinations by copula regression.''. Journal of the Royal Statistical Society: Series C 59:544-546, 2010.

Last updated: 1/30/2013