Ying Yuan, Ph.D.
Department of Biostatistics, Division of Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Adjunct Professor, Dept of Statistics, Rice University, Houston, TX
Associate Faculty Member, The University of Texas Graduate School of Biomedical Science, Houston, TX
Research Interests
Bayesian clinical trial design Statistical analysis of missing data and longitudinal data Mediation analysis Survey sampling
More about my research can be found at http://odin.mdacc.tmc.edu/~yyuan
Education & Training
Degree-Granting Education
| 2005 | University of Michigan, Ann Arbor, MI, USA, PHD, Biostatistics |
| 2000 | Brandeis University, Waltham, MA, USA, MS, Biochemistry |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Liu S, Yuan Y. Bayesian Optimal Interval Designs for Phase I Clinical Trials. Journal of the Royal Statistical Society: Series C 64:507-523, 2015.
- Liu S, Yuan Y, Castillo R, Guerrero T, Johnson VE. Evaluation of image registration spatial accuracy using a Bayesian hierarchical model. Biometrics 70(2):366-77, 2014. e-Pub 2014. PMID: 24575781.
- Cai C, Yuan Y, Ji Y. A Bayesian Dose-finding Design for Oncology Clinical Trials of Combinational Biological Agents. J R Stat Soc Ser C Appl Stat 63(1):159-173, 2014. PMID: 24511160.
- Jin IH, Liu S, Thall PF, Yuan Y. Using data augmentation to facilitate conduct of phase I/II clinical trials with delayed outcomes. J Am Stat Assoc 109(506):525-536, 2014. PMID: 25382884.
- Ahn J, Yuan Y, Parmigiani G, Suraokar MB, Diao L, Wistuba II, Wang W. DeMix: deconvolution for mixed cancer transcriptomes using raw measured data. Bioinformatics 29(15):1865-71, 2013. e-Pub 2013. PMID: 23712657.
- Jin IH, Yuan Y Liang F. Bayesian analysis for exponential random graph models using the adaptive exchange sampler. Statistics and Is Interface 6:559-576, 2013. PMID: 3956133.
- Cai C, Yuan Y, Johnson VE. Bayesian adaptive phase II screening design for combination trials. Clin Trials 10(3):353-62, 2013. e-Pub 2013. PMID: 23359875.
- Zhang G, Yuan Y. Bayesian Modeling Longitudinal Dyadic Data with Nonignorable Dropout With Application to a Breast Cancer Study. Ann Appl Stat 6(2):753-771, 2012. PMID: 23814631.
- Yuan Y, Johnson VE. Goodness-of-Fit diagnostics for Bayesian Hierarchical Models. Biometrics 68(1):156-64, 2012. e-Pub 2011. PMID: 22050079.
- Yin G, Yuan Y. Bayesian model averaging continual reassessment method in phase I clinical trials. Journal of the American Statistical Association 104(487):954-968, 2012.
- Schover LR, Canada AL, Yuan Y, Sui D, Neese L, Jenkins R, Rhodes MM. A randomized trial of internet-based versus traditional sexual counseling for couples after localized prostate cancer treatment. Cancer 118(2):500-509, 2012. e-Pub 2011. PMID: 21953578.
- Yuan Y, Thall PF, Wolff JE. Estimating progression-free survival in paediatric brain tumour patients when some progression statuses are unknown. J R Stat Soc Ser C Appl Stat 61(1):135-149, 2012. PMID: 22408277.
- Huo L, Yuan Y, Yin G. Bayesian Dose Finding for Combined Drugs with Discrete and Continuous Doses. Bayesian Anal 7(4):235-252, 2012. PMID: 23956811.
- Yuan Y, Yin G. Dose-response curve estimation: A semiparametric mixture approach. Biometrics 67(4):1543-54, 2011. e-Pub 2011. PMID: 21627631.
- Yuan Y, Yin G. Robust EM continual reassessment method in oncology dose finding (featured article). J Am Stat Assoc 106(495):818-831, 2011. PMID: 22375092.
- Yuan Y, Yin G. Bayesian hybrid design in phase I oncology clinical trials. Statistics in Medicine 30(17):2098-2108, 2011. e-Pub 2011. PMID: 21365672.
- Yuan Y, Huang X, Liu S. A Bayesian response-adaptive covariate-balanced randomization design with application to a leukemia clinical trial. Stat Med 30(11):1218-29, 2011. e-Pub 2011. PMID: 21432894.
- Lei X, Yuan Y, Yin G. Bayesian phase II adaptive randomization by jointly modeling time-to-event efficacy and binary toxicity. Lifetime Data Analysis 17(1):156-74, 2011. e-Pub 2010. PMID: 20364321.
- Carmack, CL, Basen-Engquist, K, Yuan, Y, Rodriguez-Bigas, M, Wolff, R, Barker T., Pennebaker J. Feasibility of an expressive-disclosure group intervention for post-treatment colorectal cancer patients: Results of the Healthy Expressions study. Cancer 117:4993-5002, 2011.
- Le-Petross HT, Whitman GJ, Atchely DP, Yuan Y, Gutierrez-Barrera A, Berry D, Hortobagyi GN, and Arun BK. Effectiveness of alternating mammography and magnetic resonance imaging for screening women at high risk of breast cancer. Cancer 117:3900-3907, 2011.
- Yuan Y and Yin G. On adaptive randomization: is it useful?. Journal of Clinical Oncology 29:e390-e392, 2011. e-Pub 2011.
- Yuan Y, Yin G. Bayesian Phase I/II Adaptively Randomized Oncology Trials With Combinded Drugs. Ann Appl Stat 5(2A):924-942, 2011. PMID: 22375162.
- Yuan Y, Yin G. Quantile regression for longitudinal studies with nonignorable missing data. Biometrics 66:105-114, 2010. e-Pub 2009. PMID: 19459836.
- Yin G, Yuan, Y. Rejoinder to the correspondence of Gasparini, Bailey and Neuen- schwander on \Bayesian dose finnding in oncology for drug combinations by copula regression.". Journal of the Royal Statistical Society: Series C 59:544-546, 2010.
- Yuan Y, MacKinnon DP. Bayesian mediation analysis. Psychological Methods 14(4):301-22, 2009. PMID: 19968395.
- Kiserud CE, Schover LR, Dahl AA, Fosså A, Bjøro T, Loge JH, Holte H, Yuan Y, Fosså SD. Do male lymphoma survivors have impaired sexual function?. J Clin Oncol 27(35):6019-26, 2009. e-Pub 2009. PMID: 19858388.
- Yin G, Yuan Y. A latent contingency table approach to dose finding for combinations of two agents. Biometrics 65(3):866-75, 2009. e-Pub 2008. PMID: 18759848.
- Yuan Y, Little RJ. Meta-analysis of studies with missing data. Biometrics 65(2):487-96, 2009. e-Pub 2008. PMID: 18565168.
- Yuan Y, Little RJ. Mixed-effect hybrid models for longitudinal data with nonignorable dropout. Biometrics 65(2):478-86, 2009. e-Pub 2008. PMID: 18759842.
- Song P.X., Li M, Yuan Y. Joint regression analysis of correlated data using Gaussian copulas. Biometrics 65(1):60-68, 2009. e-Pub 2008. PMID: 18510653.
- Yin G, Yuan Y. Bayesian dose-finding in oncology for drug combinations by copula regression. Journal of the Royal Statistical Society: Series C 58:211-224, 2009.
- Yuan Y, Yin G. Bayesian dose-finding by jointly modeling toxicity and efficacy as time-to-event outcomes. Journal of the Royal Statistical Society: Series C 58:719-736, 2009.
- Yuan Y, Yin G. Sequential continual reassessment method for two-dimensional dose finding. Statistics in Medicine 27(27):5664-78, 2008. PMID: 18618901.
- Yuan Y, Johnson VE. Bayesian hypothesis tests using nonparametric statistics. Statistica Sinica 18:1185-1200, 2008.
- Yuan Y, Little R.J.A.. Model-based inference for two-stage cluster samples subject to nonignorable item nonresponse. Journal of Official Statistics 24(2):193-211, 2008.
- Yuan Y, Little RJ. Parametric and semiparametric model-based estimates of the finite population mean for two-stage cluster samples with item nonresponse. Biometrics 63(4):1172-80, 2007. e-Pub 2007. PMID: 17489967.
- Kolker JL, Yuan Y, Burt BA, Sandretto AM, Sohn W, Lang SW, Ismail AI. Dental caries and dietary patterns in low-income African American children. Pediatr Dent 29(6):457-64, 2007. PMID: 18254414.
- Yuan Y, Little RJA. Model-based estimates of the finite population mean for two-stage cluster samples with unit non-response. Journal of the Royal Statistical Society:Series C 56(1):79-97, 2007. e-Pub 2007.
- Zhou J, Yuan Y, Reynolds R, Raber S, Li Y. Cost-efficient higher-order crossover designs for two-treatment clinical trials. Clinical Pharmacokinetics 45:623-632, 2006. PMID: 16719543.
- Johnson VE, Yuan Y. Comments on 'An Exploratory Test for Excess of Signi. Clinical Trials 4(3):254-255; discussion 256-7, 2006. PMID: 17715250.
- Yuan Y, Zhou J. Cost-Efficient Higher-Order Crossover Designs for Two-Treatment Clinical Trials. Pharmaceutical Statistics 4:245-252, 2005. e-Pub 2005. PMID: Not in PubMed.
- Zhou J, He Y, Yuan Y. Comparison of Schuirmann's Two One-Sided Tests with Nonparametric Two One-Sided Tests for Non-normal Data in Clinical Drug-Drug Interaction Studies. Online Journal of Pharmacology and Pharmacokinetics 2:33-43, 2004. PMID: Not in PubMed.
Book Chapters
- Yin G, Yuan Y’. Bayesian approach for adaptive design. In: Handbook of Adaptive Designs in Pharmaceutical and Clinical Development, 2010.
Books (edited and written)
- Yuan Y, Nguyen H, Thall P. Bayesian Design for Phase I-II Clinical Trials,. In: CRC Biostatistics Series. Chapman and Hall/CRC Press, 2016.
Grant & Contract Support
| Title: | Fast Track: An Adaptive Phase I/II Dose Escalation Trial of Sterotactic Body Radiation Therapy in Combination with Radiomodulating Agent GC4419 in Locally Advanced Pancreatic AdenoCarcinoma |
| Funding Source: | Galera Therapeutics, Inc |
| Role: | Co-Investigator |
| Title: | Immunotherapy Targeting Stromal CD5L in Ovarian Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Biostatistician |
| Title: | Consortium for the Study of Chronic Pancreatis, Diabetes and Pancreatic Cancer: Coordination and Data Management Center (CSCPDPC-CDMC) |
| Funding Source: | NIH/NIDDK |
| Role: | Principal Investigator |
| Title: | Expanding Tobacco Use Cessation in Northeast Texas |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Evaluator |
| Title: | Using multiple-source data and machine learning methods to predict clinical response for cancer patients |
| Funding Source: | Boehringer Ingelheim Pharmaceuticals, Inc |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified September 17, 2024