Abhineet Uppal, M.D.
Department of Colon & Rectal Surgery, Division of Surgery
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Colon & Rectal Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Genetics and Immunology of colon and rectal cancers
Treatment pathways for colorectal carcinomatosis
Patient-centered outcomes after surgery
Clinical Interests
Multi-disciplinary treatment of colon and rectal cancers
Improving access to cancer care using technology
Education & Training
Degree-Granting Education
| 2010 | University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, MD, Medicine |
| 2006 | University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, BS, Biochemistry |
Postgraduate Training
| 2019-2020 | Clinical Fellowship, Colon and Rectal Surgery, University of California at Irvine, Orange, CA |
| 2017-2019 | Clinical Fellowship, Complex General Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA |
| 2012-2014 | Research Fellowship, University of Chicago, Chicago, IL |
| 2010-2017 | Clinical Residency, General Surgery, University of Chicago, Chicago, IL |
Board Certifications
| 2021 | Colorectal Surgery |
| 2020 | Complex General Surgical Oncology |
| 2018 | General Surgery |
Honors & Awards
| 2018 | Harold McAlister Fellow, John Wayne Cancer Institute |
| 2009 | Alpha Omega Alpha |
| 2006 | Phi Beta Kappa |
Selected Publications
Peer-Reviewed Articles
- Scholer AJ, Uppal A, Chang SC, Ghosh D, Garland-Kledzik M, Santamaria-Barria J, Khader A, Dehal A, Fischer T, Goldfarb M. Inaccurate pretreatment staging can impact survival in early stage esophageal adenocarcinoma. J Surg Oncol. e-Pub 2020. PMID: 32632944.
- Uppal A, Stern S, Thompson JF, Foshag L, Mizzollo N, Nieweg OE, Hoekstra HJ, Roses DF, Sondak VK, Kashani-Sabet M, Coventry BJ, Cochran AJ, Fujita M, Sim-Shin M, Elashoff D, Elashoff RM, Faries MB. Regional Node Basin Recurrence in Melanoma Patients: More Common After Node Dissection for Macroscopic Rather than Clinically Occult Nodal Disease. Ann Surg Oncol 27(6):1970-1977, 2020. e-Pub 2019. PMID: 31863416.
- Uppal A, Dehal A, Chang SC, Barrak D, Naeini Y, Jalas JR, Bilchik AJ. The Immune Microenvironment Impacts Survival in Western Patients with Gastric Adenocarcinoma. J Gastrointest Surg 24(1):28-38, 2020. e-Pub 2019. PMID: 31625020.
- Uppal A, Smieliauskas F, Sharma MR, Maron SB, Polite BN, Posner MC, Turaga K. Facilities that service economically advantaged neighborhoods perform surgical metastasectomy more often for patients with colorectal liver metastases. Cancer 126(2):281-292, 2020. e-Pub 2019. PMID: 31639217.
- Uppal A, Wang M, Fischer T, Goldfarb M. Duodenal GI stromal tumors: Is radical resection necessary?. J Surg Oncol 120(6):940-945, 2019. e-Pub 2019. PMID: 31401812.
- Uppal A, Vuong B, Dehal A, Stern SL, Mejia J, Weerasinghe R, Kapoor V, Ong E, Hansen PD, Bilchik AJ. Can high-volume teams of anesthesiologists and surgeons decrease perioperative costs for pancreatic surgery?. HPB (Oxford) 21(5):589-595, 2019. e-Pub 2018. PMID: 30366882.
- Voce DJ, Bernal GM, Wu L, Crawley CD, Zhang W, Mansour NM, Cahill KE, Szymura SJ, Uppal A, Raleigh DR, Spretz R, Nunez L, Larsen G, Khodarev NN, Weichselbaum RR, Yamini B. Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma. Cancer Res 79(10):2536-2548, 2019. e-Pub 2019. PMID: 30940658.
- Vuong B, Dehal A, Uppal A, Stern SL, Mejia J, Weerasinghe R, Kapoor V, Ong E, Hansen PD, Bilchik AJ. What Are the Most Significant Cost and Value Drivers for Pancreatic Resection in an Integrated Healthcare System?. J Am Coll Surg 227(1):45-53, 2018. e-Pub 2018. PMID: 29580880.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nat Commun 9(1):1793, 2018. e-Pub 2018. PMID: 29728604.
- Oshima G, Guo N, He C, Stack ME, Poon C, Uppal A, Wightman SC, Parekh A, Skowron KB, Posner MC, Lin W, Khodarev NN, Weichselbaum RR. In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases. Mol Ther 25(7):1588-1595, 2017. e-Pub 2017. PMID: 28457664.
- Oshima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones. J Vis Exp(117), 2016. e-Pub 2016. PMID: 27929457.
- Wong AC, Watson SP, Pitroda SP, Son CH, Das LC, Stack ME,Uppal A, Oshima G, Khodarev NN, Salama JK, Weichselbaum RR, Chmura SJ. Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT). Cancer 122(14):2242-50, 2016. e-Pub 2016. PMID: 27206146.
- Uppal A, White MG, Nagar S, Aschebrook-Kilfoy B, Chang PJ, Angelos P, Kaplan EL, Grogan RH. Benign and Malignant Thyroid Incidentalomas Are Rare in Routine Clinical Practice: A Review of 97,908 Imaging Studies. Cancer Epidemiol Biomarkers Prev 24(9):1327-31, 2015. e-Pub 2015. PMID: 26160694.
- Oshima G, Wightman SC, Uppal A, Stack ME, Pitroda SP, Oskvarek JJ, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Imaging of tumor clones with differential liver colonization. Sci Rep 5:10946, 2015. e-Pub 2015. PMID: 26094901.
- Uppal A, Wightman SC, Mallon S, Oshima G, Pitroda SP, Zhang Q, Huang X, Darga TE, Huang L, Andrade J, Liu H, Ferguson MK, Greene GL, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR. 14q32-encoded microRNAs mediate an oligometastatic phenotype. Oncotarget 6(6):3540-52, 2015. PMID: 25686838.
- Uppal A, Ferguson MK, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR. Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs. Clin Exp Metastasis 31(6):735-48, 2014. e-Pub 2014. PMID: 24968866.
- Uppal A, Wightman SC, Ganai S, Weichselbaum RR, An G. Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model. Theor Biol Med Model 11:17, 2014. e-Pub 2014. PMID: 24725600.
- Zayed MA, Uppal A, Hartnett ME. New-onset maternal gestational hypertension and risk of retinopathy of prematurity. Invest Ophthalmol Vis Sci 51(10):4983-8, 2010. e-Pub 2010. PMID: 20463319.
- Mehl BP, House RL, Uppal A,, Reams AJ, Zhang C, Kirschbrown JR, Papanikolas JM. Direct imaging of optical cavity modes in ZnO rods using second harmonic generation microscopy. J Phys Chem A 114(3):1241-6, 2010. PMID: 19588988.
- Saito Y, Uppal A, Byfield G, Budd S, Hartnett ME. Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model. Invest Ophthalmol Vis Sci 49(4):1591-8, 2008. PMID: 18385079.
- Saito Y, Geisen P, Uppal A, Hartnett ME. Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity. Mol Vis 13:840-53, 2007. e-Pub 2007. PMID: 17615545.
Patient Reviews
CV information above last modified February 23, 2023