Adam Grippin, MD,PHD
Department of Thoracic Radiation Oncology, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Assistant Professor, Thoracic Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Thoracic Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2019 | University of Florida College of Medicine, Gainesville, Florida, US, PhD, Biomedical Engineering with Certificate in Clinical and Translational Science |
| 2021 | University of Florida College of Medicine, Gainesville, Florida, US, MD |
| 2013 | University of Florida, Gainesville, Florida, US, BS, Chemical Engineering |
Postgraduate Training
| 2022-2026 | Resident, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2021-2022 | Transitional Year, University of Central Florida/HCA GME Consortium, Orlando, Florida |
Licenses & Certifications
| 2024 | American Heart Association Advanced Basic Life Support |
| 2022 | State of Texas Physician-in-Training Medical License |
Experience & Service
Faculty Academic Appointments
NIH T32 Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2023 - 2026
Resident, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2022 - 2026
Graduate Student, University of Florida, Gainesville, Florida, 2015 - 2021
Other Professional Positions
Member, Early Career Committee, Society for the Immunotherapy of Cancer, 2025 - Present
Co-Founder, Resident Research Accelerator, Created an infrastructure to facilitate resident research from conception through publication, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2023 - Present
Founder and Board Member, Founded a statewide organization for student run free clinics to coordinate efforts, Florida Clinics Collaborative, 2019 - 2021
Executive Director, Equal Access Clinic Network, 2017 - 2019
Physician Recruitment Director, Equal Access Clinic Network, 2014 - 2016
Chemical Engineering Research Intern, Identified methods to produce tortilla chips more resistant to breakage. This work contributed to production of Tostito’s Cantina ThinsTM, PepsiCo Global Research and Development, Plano, Texas
Panel Member, mRNA Cancer Vaccine Roundtable, Alliance for mRNA Medicines
Honors & Awards
| Undergraduate Student Environmental Chemistry Award, American Chemical Society | |
| Howard Hughes Medical Institute Extramural Research Award, University of Florida | |
| Science Undergraduate Laboratory Internship, U.S. Department of Energy | |
| Outstanding Scholar Athlete, Collegiate Water Polo Association | |
| Graduate Student Research Fellowship, University of Florida Department of Biomedical Engineering | |
| Graduate Student Research Award, Circle of Hope for Cancer Research | |
| McKnight Brain Institute Research Fellowship, University of Florida | |
| TL1 Training Award, Clinical and Translational Science Institute, University of Florida | |
| Dissertation Award, UFHealth Cancer Center | |
| Best Oral Presentation, Pruitt Family Research Day | |
| Graduate Student Research Award, Circle of Hope for Cancer Research | |
| Ruth L. Kirschstein National Research Service Award, National Cancer Institute, NIH | |
| Graduate Student Research Award, Circle of Hope for Cancer Research | |
| Best Poster Award, Therapeutic Vaccination category, CIMT Annual Meeting, Germany | |
| Best Oral Presentation, University of Florida Biomaterials Day | |
| Best Oral Presentation, University of Florida Biomaterials Day | |
| Semi-Finalist, University of Florida Medical Student Research Program | |
| Hall of Fame, University of Florida | |
| J. Robert Cade, M.D. Memorial Award, University of Florida | |
| Radiation Oncology All-Star Award, The University of Texas, MD Anderson Cancer Center | |
| Cancer Nanotechnology T32 Training Grant, MD Anderson/Rice University | |
| Early Career Education Award, IASLC 2023 World Conference on Lung Cancer | |
| Poster Finalist and Travel Award, Texas Lung Cancer Conference 2024 Poster Competition | |
| Jeffrey Lee Cousins Fellowship in Lung Cancer Research, The University of Texas MD Anderson Cancer Center | |
| Annual Meeting Basic Translational Abstract Award, American Society for Radiation Oncology | |
| Merit Travel Grant, European Society for Medical Oncology Congress | |
| Young Investigator Abstract Travel Award, Society for the Immunotherapy of Cancer | |
| American Brain Tumor Association Fellowship, American Brain Tumor Association | |
| Trainee Peer-to-Peer Mentor Award | |
| Daniel D. Von Hoff Award, AACR/ASCO Clinical Trials Workshop | |
| Resident/Fellow Research Grant, Radiological Society of America | |
| Doreen J. Putrah Cancer Research Foundation Scholar-in-Training Award, American Association of Cancer Research | |
| Conquer Cancer Young Investigator Award, American Society for Clinical Oncology | |
| Young Investigator Abstract Travel Award, Society for the Immunotherapy of Cancer | |
| ASTRO Annual Meeting Abstract Award, American Society for Radiation Oncology | |
| STAT Wunderkind, STAT News | |
| AACR Next Gen Star Award, American Association For Cancer Research | |
| Best Oral Presentation, MD Anderson Flash Talk Competition | |
| Top Ten Clinical Research Achievement Award, Clinical Research Forum |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2027. Harnessing innate activation of mRNA therapeutics. Invited. Gordon Research Conference. Houston, Texas, US.
- 2026. Challenging paradigms: My journey as a physician scientist. Invited. CATALYST Summer Research Student Symposium. Houston, Texas, US.
- 2024. Immunologic impacts of SARS-COV-2 mRNA vaccines. Invited. Alamar Biosciences Seminar. Houston, Texas, US.
Regional Presentations
- 2019. Modifiable RNA loaded lipid nanoparticles function as immunotherapeutic vehicles against glioblastoma. Society for Neuro-Oncology. Phoenix, Arizona, US.
- 2019. Bifunctional RNA nanoparticles induce antitumor immune responses and allow MRI-based detection of dendritic cell migration as a biomarker of antitumor immune response. Biomaterials Day. Gainesville, Florida, US.
- 2018. Bifunctional RNA nanoparticles induce antitumor immune responses and allow MRI-based detection of dendritic cell migration as a biomarker of antitumor immune response. Society for Neuro-Oncology. New Orleans, Louisiana, US.
- 2018. Introduction to the Equal Access Clinic Network. Invited. University of Florida College of Medicine. Gainesville, Florida, US.
- 2018. Cancer Immunotherapy. Invited. Medical Sciences Journal Club. Gainesville, Florida, US.
- 2018. mRNA-loaded magnetoliposomes enhance antitumor responses to dendritic cell vaccines and enable MRI-based detection of cell migration. Biomaterials Day. Gainesville, Florida, US.
- 2017. Engineering RNA-nanoparticles to treat brain tumors. Invited. University of Florida Introduction to Biomedical Engineering. Gainesville, Florida, US.
- 2017. Development of Bi-functional RNA-nanoparticles to Enhance and Track Dendritic Cell Vaccines. Pruitt Research Day. Gainesville, Florida, US.
- 2017. Engineering RNA-nanoparticles to treat brain tumors. Invited. University of Florida Magnetics Seminar Series. Gainesville, Florida, US.
- 2017. Engineering RNA-nanoparticles to treat brain tumors. Invited. Orange County Commissioner's Meeting. Kissimmee, Florida, US.
National Presentations
- 2026. Mechanisms by which RNA vaccines stimulate antitumor immune responses. Invited. American Association for Cancer Research.
- 2026. Beyond Personalized Medicine: Exploiting adjuvant effects of mRNA vaccines. Invited. American Association for Clinical Research. San Diego, California, US.
- 2026. Beyond Personalized Medicine: Exploiting adjuvant effects of mRNA vaccines. Invited. Melanoma Research Conference. San Francisco, California, US.
- 2025. Beyond Personalized Medicine: Exploiting adjuvant effects of mRNA vaccines. Invited. Hem/Onc Grand Rounds. Ithaca, New York, US.
- 2025. SARS-CoV-2 mRNA vaccines sensitize intracranial tumors to immune checkpoint blockade. Society for Neuro-Oncology. Honolulu, Hawaii, US.
- 2025. Designing mRNA therapeutics to sensitize responses to immune checkpoint blockade. Invited. Parker Institute for Cancer Immunotherapy Cancer Vaccine Summit.
- 2025. SARS-CoV-2 mRNA vaccines sensitize tumors to immune checkpoint blockade. Invited. American Association for Clinical Research. Chicago, Illinois, US.
- 2025. Pre-vaccine radiation and CTLA-4 blockade increase adjuvant effects of SARS-CoV-2 mRNA vaccines. 2025 AACR Special Conference on Translating Targeted Therapies in Combination with Radiotherapy. San Diego, California, US.
- 2024. SARS-COV-2 mRNA vaccines are associated with Type I interferon signaling and improved clinical responses to immune checkpoint inhibition. Society for the Immunotherapy of Cancer. Houston, Texas, US.
- 2024. IMMUNOCERV Phase II trial combining the HPV-specific T cell immunotherapy PDS0101 with chemoradiation for treatment of locally advanced cervical cancer. American Society for Radiation Oncology. Washington, D.C, District of Columbia, US.
- 2023. Versatile mRNA-nanoparticle platform to initiate anti-tumor immune responses, manipulate the brain tumor microenvironment, and predict treatment response. American Radium Society. Lahaina, Hawaii, US.
- 2020. Customizable mRNA-Nanoparticles for treatment of glioblastoma. 35th Annual MD/PhD National Student Conference. Denver, Colorado, US.
International Presentations
- 2026. Beyond personalized medicine: Dissecting mechanisms by which mRNA vaccines stimulate antitumor immunity. Invited. Cancer Immunotherapy Meeting.
- 2026. Beyond Personalized Medicine: Exploiting adjuvant effects of mRNA vaccines. Invited. Gustave Roussey. Paris, FR.
- 2025. SARS-CoV-2 mRNA vaccines sensitize tumors to immune checkpoint blockade. European Society for Medical Oncology. Berlin, DE.
- 2024. Association of SARS-COV-2 mRNA vaccines with tumor PD-L1 expression and clinical responses to immune checkpoint blockade. European Society for Medical Oncology. Barcelona, ES.
- 2023. Timing of pre-biopsy COVID-mRNA vaccination and PD-L1 expression in advanced non-small cell lung cancer. World Conference on Lung Cancer. Singapore, SG.
- 2018. Bifunctional RNA-nanoparticles to enhance dendritic cell activation and enable MRI-based detection of dendritic cell migration to lymph nodes. Cancer Immunotherapy Meeting. Mainz, DE.
Grant & Contract Support
| Date: | 2026 - 2031 |
| Title: | Dissecting mechanisms by which mRNA vaccines encoding nontumor antigens initiate antitumor immunity |
| Funding Source: | National Cancer Institute |
| Role: | PI |
| Date: | 2025 - 2026 |
| Title: | Integrating mRNA vaccines into multimodality cancer therapy |
| Funding Source: | MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2025 - 2026 |
| Title: | mRNA vaccines and therapeutic radiation for non-small cell lung cancer |
| Funding Source: | ASTRO and LUNGevity |
| Role: | PI |
| Date: | 2025 - 2026 |
| Title: | Impact of COVID mRNA vaccines on immune checkpoint inhibition |
| Funding Source: | American Society for Clinical Oncology |
| Role: | PI |
| Date: | 2024 - 2026 |
| Title: | In Situ Generation of GD20 CAR Macrophages to Treat H3K27M Diffuse Midline Glioma |
| Funding Source: | American Brain Tumor Association |
| Role: | PI |
| Date: | 2024 - 2025 |
| Title: | Restoration of LKB1 expression to sensitize tumors to chemoradiation |
| Funding Source: | Radiological Society of America |
| Role: | PI |
| Date: | 2023 - 2025 |
| Title: | Exosomes for temporary gene modification |
| Funding Source: | Rice University |
| Role: | Trainee |
| Date: | 2019 - 2024 |
| Title: | High quality, free care for all at the Equal Access Clinic Network |
| Funding Source: | Jules B. Chapman and Annie Lou Chapman Foundation |
| Role: | PI |
| Date: | 2018 - 2021 |
| Title: | Engineering RNA-nanoparticles to enhance dendritic cell mediated treatment of glioblastoma |
| Funding Source: | Ruth L. Kirschstein National Research Service Award |
| Role: | PI |
| Date: | 2018 - 2019 |
| Title: | Expanding Capacity at the Equal Access Clinic Network |
| Funding Source: | University of Florida Medical Guild |
| Role: | PI |
| Date: | 2018 - 2019 |
| Title: | Expanding Capacity at the Equal Access Clinic Network |
| Funding Source: | Community Agency Partnership Program |
| Role: | PI |
| Date: | 2018 - 2019 |
| Title: | Basic Operations at the Equal Access Clinic Network |
| Funding Source: | Jules B. Chapman and Annie Lou Chapman Foundation |
| Role: | PI |
| Date: | 2018 - 2019 |
| Title: | Engineering a clinically accessible biomarker for glioblastoma immunotherapy |
| Funding Source: | Circle of Hope for Cancer Research, INC Graduate Student Research Award |
| Role: | PI |
| Date: | 2017 - 2018 |
| Title: | Engineering Delivery of Immunomodulatory RNA-nanoparticles Targeting Malignant Glioma |
| Funding Source: | UFHealth Cancer Center Dissertation Award |
| Role: | PI |
| Date: | 2017 - 2018 |
| Title: | Capacity Expansion at the Equal Access Clinic Network |
| Funding Source: | Florida Association for Free and Charitable Clinics |
| Role: | PI |
| Date: | 2017 - 2018 |
| Title: | Engineering a clinically accessible biomarker for glioblastoma immunotherapy |
| Funding Source: | Circle of Hope for Cancer Research, INC Graduate Student Research Award |
| Role: | PI |
| Date: | 2016 - 2018 |
| Title: | Magnetic nanoparticles facilitate tracking of dendritic cells for treatment of brain tumors |
| Funding Source: | Clinical and Translational Science TL1 Training Program |
| Role: | PI |
| Date: | 2016 - 2018 |
| Title: | mRNA-loaded magnetic nanoparticles for treatment of glioblastoma |
| Funding Source: | McKnight Brain Institute Fellowship |
| Role: | PI |
| Date: | 2016 - 2017 |
| Title: | Engineering a clinically accessible biomarker for glioblastoma immunotherapy |
| Funding Source: | Circle of Hope for Cancer Research, INC Graduate Student Research Award |
| Role: | PI |
| Date: | 2015 - 2016 |
| Title: | Engineering nanoparticles to treat glioblastoma |
| Funding Source: | University of Florida Graduate Student Fellowship |
| Role: | PI |
Selected Publications
Peer-Reviewed Articles
- Tian Y, Liu Y, Tong Y, Huntoon K, Yang L, Shi J, Ma Y, Dong S, Jeong SD, Estania AP, Yi Y, Kwak KJ, Wang Y, Wu A, Edwards JL, Wang X, Chang YT, Cao J, Zhang H, Sun M, Grippin AJ, Yang Z, Lu WJ, Lee LJ, Bahrani E, Zhang H, Bai L, Nguyen PK, Jiang W, Lan F, Kim BYS, Lee AS. Skeletal-muscle-targeted non-viral delivery of full-length DMD mRNA for Duchenne muscular dystrophy. Nat Biomed Eng, 2026. e-Pub 2026. PMID: 42277318.
- Xu X, Saad MB, Grippin A, Xu H, Muneer A, Young E, Lin SH, Liao Z, Gandhi S, Balter P, Ning MS, Qian D, Bronk JK, Chen A, O'Reilly M, Nguyen QN, Welsh J, Pollard-Larkin JM, Heymach JV, Lee JJ, Wu J, Chang JY. SARS-CoV-2 mRNA Vaccination Improved Survival in NSCLC Treated With Radiotherapy. J Thorac Oncol:103956, 2026. e-Pub 2026. PMID: 42229634.
- Au CC, Azorin DD, Carrot-Zhang J, Corsello SM, Curiel-Garcia A, Freed-Pastor W, Grippin AJ, Nguyen LC, Pillai R, Sreekumar A, Zabransky DJ. Insights on Future Directions in Cancer Research from the 2026 AACR NextGen Stars. Cancer Discov 16(4):670-676, 2026. e-Pub 2026. PMID: 41918358.
- Ha J, Wang Y, Ma Y, Wu A, Dong S, Jeong SD, Edwards JL, Chang M, Chang YT, Wang X, Dufilho M, Najarro Torres M, McCabe S, Deng W, Grippin AJ, Weinberg JS, Raza SM, DeMonte F, McCutcheon IE, Prabhu S, Ferguson SD, Ene CI, Akdemir K, Basu S, Jindal S, Schrank BR, Hu J, Goswami S, Puduvalli VK, Lang FF, Huntoon K, Sharma P, Kim BYS, Jiang W. Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma. Nat Commun 17(1), 2026. e-Pub 2026. PMID: 41803138.
- Grippin AJ, Marconi C, Copling S, Li N, Braun C, Woody C, Young E, Gupta P, Wang M, Wu A, Jeong SD, Soni D, Weidert F, Xie C, Goldenberg E, Kim A, Zhao C, DeVries A, Castillo P, Lohray R, Rooney MK, Schrank BR, Wang Y, Ma Y, Chang E, Kouzy R, Dyson K, Jafarnia J, Nariman N, Gladish G, New J, Argueta A, Amaya D, Thomas N, Doty A, Chen J, Copling N, Alatrash G, Simon J, Davies AB, Dennis W, Liang R, Lewis J, Wei X, Rinsurongkawong W, Vaporciyan AA, Johns A, Lee J, Lee JH, Sun R, Sharma P, Tran H, Zhang J, Gibbons DL, Wargo J, Kim BYS, Heymach JV, Mendez-Gomez HR, Jiang W, Sayour EJ, Lin SH. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. Nature 647(8089):488-497, 2025. e-Pub 2025. PMID: 41125896.
- Grippin AJ, Jiang W. Mitochondrial proteins go public and novel interactions: insights from surfaceome mapping. Nat Rev Immunol 25(9):636, 2025. e-Pub 2025. PMID: 40702235.
- Qdaisat S, Wummer B, Stover BD, Zhang D, McGuiness J, Weidert F, Chardon-Robles J, Grippin A, DeVries A, Zhao C, Marconi C, Karachi A, Xie C, Jobin G, Liu R, Michel S, Ma X, Moor RSF, von Roemeling C, Nguyen DT, Elliott L, Thomas N, Barpujari A, Geffrard H, Campaneria Y, Ogando-Rivas E, Rabideau C, Soni D, Huang J, Carrera-Justiz S, Fredenburg K, Silver NL, Sawyer WG, Rahman M, Ligon JA, Flores CT, Lee JH, Mitchell DA, Castillo P, Mendez-Gomez HR, Sayour EJ. Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nat Biomed Eng 9(9):1437-1452, 2025. e-Pub 2025. PMID: 40681861.
- Noticewala SS, Grippin AJ, Kouzy R, Abi Jaoude J, Miller A, Sherry A, Ludmir EB. Effect size estimation in cooperative group- and industry-sponsored phase 3 oncology trials. J Natl Cancer Inst 117(8):1738-1742, 2025. e-Pub 2025. PMID: 40220316.
- Wang Y, Song H, Teng Y, Huang G, Qian J, Wang H, Dong S, Ha J, Ma Y, Chang M, Jeong SD, Deng W, Schrank BR, Grippin A, Wu A, Edwards JL, Zhang Y, Lin Y, Poon W, Wilhelm S, Bi Y, Teng L, Wang Z, Kim BYS, Jiang W. A Generative Artificial Intelligence Copilot for Biomedical Nanoengineering. ACS Nano 19(20):19394-19407, 2025. e-Pub 2025. PMID: 40367350.
- Grippin AJ, Kim A, Liu Y, Copling S, Nalin AP, Crabtree K, Cheng H, Kui N, Zhang Z, McAleer MF, Grosshans D, McGovern S, Sun R, Paulino AC. Osteoradionecrosis in Pediatric Patients Treated with Proton Therapy for Head and Neck Malignancies. Int J Radiat Oncol Biol Phys 122(1):159-163, 2025. e-Pub 2025. PMID: 39674326.
- Chung MC, Mendez-Gomez HR, Soni D, McGinley R, Zacharia A, Ashbrook J, Stover B, Grippin AJ, Sayour EJ, Guan J. Multi-Step Assembly of an RNA-Liposome Nanoparticle Formulation Revealed by Real-Time, Single-Particle Quantitative Imaging. Adv Sci (Weinh) 12(12):e2414305, 2025. e-Pub 2025. PMID: 39887619.
- Schrank BR, Wang Y, Wu A, Tran N, Lee D, Edwards J, Huntoon K, Dong S, Ha J, Ma Y, Grippin AJ, Jeong SD, Antony A, Chang M, Kang M, Gallup TD, Koong AC, Li J, Yun K, Kim BYS, Jiang W. An antibody-toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy. Nat Cancer 6(3):511-527, 2025. e-Pub 2025. PMID: 40000910.
- Seo A, Xiao W, Gjyshi O, Yoshida-Court K, Wei P, Swanson D, Cisneros Napravnik T, Grippin A, Venkatesan AM, Jacobsen MC, Fuentes DT, Lynn E, Sammouri J, Jhingran A, Joyner M, Lin LL, Colbert LE, Gillison ML, Klopp AH. Human Papilloma Virus Circulating Cell-Free DNA Kinetics in Patients with Cervical Cancer Undergoing Definitive Chemoradiation. Clin Cancer Res 31(4):697-706, 2025. e-Pub 2025. PMID: 39680029.
- von Roemeling CA, Patel JA, Carpenter SL, Yegorov O, Yang C, Bhatia A, Doonan BP, Russell R, Trivedi VS, Klippel K, Ryu DH, Grippin A, Futch HS, Ran Y, Hoang-Minh LB, Weidert FL, Golde TE, Mitchell DA. Adeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade. Nat Commun 15(1):5871, 2024. e-Pub 2024. PMID: 38997283.
- Shi C, De B, Tran Cao HS, Liu S, Florez MA, Kouzy R, Grippin AJ, Katz MHG, Tzeng CD, Ikoma N, Kim MP, Lee S, Willis J, Noticewala SS, Minsky BD, Smith GL, Holliday EB, Taniguchi CM, Koong AC, Das P, Ludmir EB, Koay EJ. Escalated-dose radiotherapy for unresected locally advanced pancreatic cancer: Patterns of care and survival in the United States. Cancer Med 13(12):e7434, 2024. e-Pub 2024. PMID: 38923407.
- Ha J, Grippin AJ, Kim BYS, Jiang W. Striking the Balance with a PD-L1x4-1BB Bispecific Antibody. Cancer Res 84(10):1546-1547, 2024. e-Pub 2024. PMID: 38745496.
- Bian X, Yang L, Jiang D, Grippin AJ, Ma Y, Wu S, Wu L, Wang X, Tang Z, Tang K, Pan W, Dong S, Kim BYS, Jiang W, Yang Z, Li C. Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles. Nat Commun 15(1):3987, 2024. e-Pub 2024. PMID: 38734698.
- Mendez-Gomez HR, DeVries A, Castillo P, von Roemeling C, Qdaisat S, Stover BD, Xie C, Weidert F, Zhao C, Moor R, Liu R, Soni D, Ogando-Rivas E, Chardon-Robles J, McGuiness J, Zhang D, Chung MC, Marconi C, Michel S, Barpujari A, Jobin GW, Thomas N, Ma X, Campaneria Y, Grippin A, Karachi A, Li D, Sahay B, Elliott L, Foster TP, Coleman KE, Milner RJ, Sawyer WG, Ligon JA, Simon E, Cleaver B, Wynne K, Hodik M, Molinaro AM, Guan J, Kellish P, Doty A, Lee JH, Massini T, Kresak JL, Huang J, Hwang EI, Kline C, Carrera-Justiz S, Rahman M, Gatica S, Mueller S, Prados M, Ghiaseddin AP, Silver NL, Mitchell DA, Sayour EJ. RNA aggregates harness the danger response for potent cancer immunotherapy. Cell 187(10):2521-2535.e21, 2024. e-Pub 2024. PMID: 38697107.
- Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC, Tainer JA, Jiang W, Kim BYS. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nat Biomed Eng 8(5):593-610, 2024. e-Pub 2024. PMID: 38641710.
- Dong S, Liu X, Bi Y, Wang Y, Antony A, Lee D, Huntoon K, Jeong S, Ma Y, Li X, Deng W, Schrank BR, Grippin AJ, Ha J, Kang M, Chang M, Zhao Y, Sun R, Sun X, Yang J, Chen J, Tang SK, Lee LJ, Lee AS, Teng L, Wang S, Teng L, Kim BYS, Yang Z, Jiang W. Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer. Nat Commun 14(1):6610, 2023. e-Pub 2023. PMID: 37857647.
- Mendez-Gomez HR, DeVries A, Castillo P, Stover BD, Qdaisat S, Von Roemeling C, Ogando-Rivas E, Weidert F, McGuiness J, Zhang D, Chung MC, Li D, Zhang C, Marconi C, Campaneria Y, Chardon-Robles J, Grippin A, Karachi A, Thomas N, Huang J, Milner R, Sahay B, Sawyer WG, Ligon JA, Silver N, Simon E, Cleaver B, Wynne K, Hodik M, Molinaro A, Guan J, Kellish P, Doty A, Lee JH, Carrera-Justiz S, Rahman M, Gatica S, Mueller S, Prados M, Ghiaseddin A, Mitchell DA, Sayour EJ. mRNA aggregates harness danger response for potent cancer immunotherapy. medRxiv, 2023. e-Pub 2023. PMID: 36993772.
- Gjyshi O, Grippin A, Andring L, Jhingran A, Lin LL, Bronk J, Eifel PJ, Joyner MM, Sastry JK, Yoshida-Court K, Solley TN, Napravnik TC, O'Hara MP, Hegde VL, Colbert LE, Klopp AH. Circulating neutrophils and tumor-associated myeloid cells function as a powerful biomarker for response to chemoradiation in locally advanced cervical cancer. Clin Transl Radiat Oncol 39:100578, 2023. e-Pub 2023. PMID: 36935860.
- Indelicato DJ, Ioakeim-Ioannidou M, Grippin AJ, Bradley JA, Mailhot Vega RB, Viviers E, Tarbell NJ, Yock TI, MacDonald SM. Bicentric Treatment Outcomes After Proton Therapy for Nonmyxopapillary High-Grade Spinal Cord Ependymoma in Children. Int J Radiat Oncol Biol Phys 112(2):335-341, 2022. e-Pub 2022. PMID: 34597719.
- Wildes TJ, Dyson KA, Francis C, Wummer B, Yang C, Yegorov O, Shin D, Grippin A, Dean BD, Abraham R, Pham C, Moore G, Kuizon C, Mitchell DA, Flores CT. Immune Escape After Adoptive T-cell Therapy for Malignant Gliomas. Clin Cancer Res 26(21):5689-5700, 2020. e-Pub 2020. PMID: 32788225.
- Long Y, Tao H, Karachi A, Grippin AJ, Jin L, Chang YE, Zhang W, Dyson KA, Hou AY, Na M, Deleyrolle LP, Sayour EJ, Rahman M, Mitchell DA, Lin Z, Huang J. Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma. Cancer Res 80(3):499-509, 2020. e-Pub 2020. PMID: 31723000.
- Grippin AJ, Wummer B, Wildes T, Dyson K, Trivedi V, Yang C, Sebastian M, Mendez-Gomez HR, Padala S, Grubb M, Fillingim M, Monsalve A, Sayour EJ, Dobson J, Mitchell DA. Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging. ACS Nano 13(12):13884-13898, 2019. e-Pub 2019. PMID: 31730332.
- Jin L, Tao H, Karachi A, Long Y, Hou AY, Na M, Dyson KA, Grippin AJ, Deleyrolle LP, Zhang W, Rajon DA, Wang QJ, Yang JC, Kresak JL, Sayour EJ, Rahman M, Bova FJ, Lin Z, Mitchell DA, Huang J. CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors. Nat Commun 10(1):4016, 2019. e-Pub 2019. PMID: 31488817.
- Wildes TJ, Grippin A, Fasanya H, Dyson KA, Brantly M. Effect of atorvastatin on humoral immune response to 23-valent pneumococcal polysaccharide vaccination in healthy volunteers: The StatVax randomized clinical trial. Vaccine 37(10):1313-1324, 2019. e-Pub 2019. PMID: 30686636.
- Sayour EJ, Grippin A, De Leon G, Stover B, Rahman M, Karachi A, Wummer B, Moore G, Castillo-Caro P, Fredenburg K, Sarkisian MR, Huang J, Deleyrolle LP, Sahay B, Carrera-Justiz S, Mendez-Gomez HR, Mitchell DA. Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy. Nano Lett 18(10):6195-6206, 2018. e-Pub 2018. PMID: 30259750.
- Wildes TJ, Grippin A, Dyson KA, Wummer BM, Damiani DJ, Abraham RS, Flores CT, Mitchell DA. Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma. Clin Cancer Res 24(16):3955-3966, 2018. e-Pub 2018. PMID: 29712687.
- Sayour EJ, De Leon G, Pham C, Grippin A, Kemeny H, Chua J, Huang J, Sampson JH, Sanchez-Perez L, Flores C, Mitchell DA. Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles. Oncoimmunology 6(1):e1256527, 2017. e-Pub 2017. PMID: 28197373.
- Woo MH, Grippin A, Anwar D, Smith T, Wu CY, Wander JD. Effects of relative humidity and spraying medium on UV decontamination of filters loaded with viral aerosols. Appl Environ Microbiol 78(16):5781-7, 2012. e-Pub 2012. PMID: 22685135.
- Woo MH, Grippin A, Wu CY, Baney RH. Use of dialdehyde starch treated filters for protection against airborne viruses. J Aerosol Sci 46:77-82, 2012. e-Pub 2012. PMID: 32226124.
Review Articles
- Grippin AJ, Lee D, Parkes EE, Jiang W, Kim BYS. Nanotechnology for immuno-oncology. Nat Cancer 6(8):1311-1325, 2025. e-Pub 2025. PMID: 40775548.
- Ma Y, Dong S, Grippin AJ, Teng L, Lee AS, Kim BYS, Jiang W. Engineering therapeutical extracellular vesicles for clinical translation. Trends Biotechnol 43(1):61-82, 2025. e-Pub 2025. PMID: 39227240.
- Zhang H, Grippin A, Sun M, Ma Y, Kim BYS, Teng L, Jiang W, Yang Z. New avenues for cancer immunotherapy: Cell-mediated drug delivery systems. J Control Release 375:712-732, 2024. e-Pub 2024. PMID: 39326499.
- Grippin AJ, McGovern SL. Proton therapy for pediatric diencephalic tumors. Front Oncol 13:1123082, 2023. e-Pub 2023. PMID: 37213290.
- Grippin AJ, Dyson KA, Qdaisat S, McGuiness J, Wummer B, Mitchell DA, Mendez-Gomez HR, Sayour EJ. Nanoparticles as immunomodulators and translational agents in brain tumors. J Neurooncol 151(1):29-39, 2021. e-Pub 2021. PMID: 32757093.
- Dyson KA, Stover BD, Grippin A, Mendez-Gomez HR, Lagmay J, Mitchell DA, Sayour EJ. Emerging trends in immunotherapy for pediatric sarcomas. J Hematol Oncol 12(1):78, 2019. e-Pub 2019. PMID: 31311607.
- Grippin AJ, Sayour EJ, Mitchell DA. Translational nanoparticle engineering for cancer vaccines. Oncoimmunology 6(10):e1290036, 2017. e-Pub 2017. PMID: 29123947.
Other Articles
- Nalin AP, Msaouel P, Grippin AJ, Kouzy R, Abi Jaoude J, Lin TA, Miller AM, Meimoun NS, Ludmir EB, Sherry AD Control arm overperformance in phase 3 oncology clinical trials. Cancer 132(4):e70306, 2026. PMID: 41653086.
Letters to the Editor
- Grippin AJ, Paulino AC. In Reply to Somay et al. Int J Radiat Oncol Biol Phys 123: 319, 2025.
Web Publications
- Wouters, M, Grippin A. COVID-19 mRNA vaccines provide a surprising boost to ICB therapy efficacy, 2025.
- Johnson M, Grippin A. Study finds mRNA coronavirus vaccines prolonged life of cancer patients, 2025.
- Neergaard L, Grippin A. COVID-19 vaccines may help some cancer patients fight tumors, 2025.
- Neergaard L, Grippin A. COVID-19 vaccines may help some cancer patients fight tumors, 2025.
- Neergaard L, Grippin A. COVID-19 vaccines may help some cancer patients fight tumors, 2025.
Patient Reviews
CV information above last modified August 25, 2026