Amin M. Alousi, M.D.
Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine
About Dr. Alousi
Dr. Alousi is Professor of Medicine in the Department of Stem Cell Transplant and Cellular Therapy at the University of Texas, MD Anderson Cancer Center where he serves as the Inpatient Medical Director as well as the Director of the Multi-Discipline Graft-vs.-Host Disease (GVHD) Clinic and Research Program. His area of research is in the prevention and treatment of acute and chronic GVHD as well as survivorship needs in recipients of allogeneic hematopoietic cell transplantation. He has served as principle investigator of numerous single-center and multi-center trials investigating novel therapies in the prevention and treatment of GVHD. He is the prior co-chair for the Center for International Blood and Marrow Research GVHD Study Section in addition to serving on the Blood and Marrow Transplant Clinical Trials Networks GVHD State of the Science Committee, National Institute of Health’s 2021 Chronic GVHD Consensus Panel, Chronic GVHD Consortium Data Safety Board and the FDA’s Acute GVHD Clinical Trials Endpoint Conference.
Present Title & Affiliation
Primary Appointment
Professor, Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Director, Department of GVHD Clinic and Research Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston
Dual/Joint/Adjunct Appointment
Adjunct Assistant Professor, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Education & Training
Degree-Granting Education
| 1997 | Wayne State University School of Medicine, Detroit, MI, USA, MD, Medicine |
Postgraduate Training
| 2005-2006 | Clinical Fellowship, Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2002-2005 | Clinical Fellowship, Hematology and Oncology, Karmanos Cancer Institute Wayne State University, Detroit, MI |
| 2001-2002 | Chief Residency, Internal Medicine, Detroit Receiving Hospital Wayne State University, Detroit, MI |
| 1997-2001 | Clinical Residency, Internal Medicine and Pediatrics, Childrens Hospital of Michigan Wayne State University, Detroit, TX |
Board Certifications
| 2017 | American Board of Hematology |
| 2006 | American Board of Medical Oncology |
| 2002 | American Board of Internal Medicine |
Experience & Service
Other Appointments/Responsibilities
Co-Chair, Center for International Blood & Marrow Transplant Research, Milwaukee, WI, 2014 - 2018
Member, U54 Data and Safety Monitoring Board (DSMB) Charter - CHRONIC GVHD CONSORTIUM, Fred Hutchinson Cancer Research Center, Seattle, WA, 2011 - Present
Member, BMT CTN GVHD State of the Science Committee, Bethesda, MD, 2011 - Present
Member, BMT CTN Steering Committee - GVHD, Bethesda, MD, 2008 - Present
Institutional Committee Activities
Member, UTMDACC Ethics and Compliance in Oncology Research (ECOR) Advisory Board, 2011 - Present
Chair, UTMDACC Clinical Research Committee (CRC 4), 2011 - Present
Chair, UTMDACC Transfusion Subcommittee, 2010 - Present
Member, UTMDACC / SCTCT - ICU Committee, 2006 - Present
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- MacMillan ML, Robin M, Harris AC, DeFor TE, Martin PJ, Alousi A, Ho VT, Bolaños-Meade J, Ferrara JL, Jones R, Arora M, Blazar BR, Holtan SG, Jacobsohn D, Pasquini M, Socie G, Antin JH, Levine JE, Weisdorf DJ. A refined risk score for acute GVHD that predicts response to initial therapy, survival and transplant-related mortality. Biol Blood Marrow Transplant 21(4):761-7, 2015. e-Pub 2015. PMID: 25585275.
- Alousi AM, Le-Rademacher J, Saliba RM, Appelbaum FR, Artz A, Benjamin J, Devine SM, Kan F, Laughlin MJ, Lazarus HM, Liesveld J, Perales MA, Maziarz RT, Sabloff M, Waller EK, Eapen M, Champlin RE. Who is the better donor for older hematopoietic transplant recipients: an older-aged sibling or a young, matched unrelated volunteer?. Blood 121(13):2567-73, 2013. e-Pub 2013. PMID: 23361908.
- Najera JE, Alousi A||B, De Lima M, Ciurea SO. Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis. Bone Marrow Transplant 48(1):157-8, 2013. e-Pub 2012. PMID: 22705799.
- Alousi AM, Bolaños-Meade J, Lee SJ. Graft-versus-Host Disease: The State of the Science. Biol Blood Marrow Transplant 19(1 Suppl):S102-8, 2013. e-Pub 2012. PMID: 23110985.
- Levine JE, Logan BR, Wu J, Alousi AM, Bolaños-Meade J, Ferrara JL, Ho VT, Weisdorf DJ, Paczesny S. Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study. Blood 119(16):3854-60, 2012. e-Pub 2012. PMID: 22383800.
- Hymes SR, Alousi AM, Cowen EW. Graft-versus-host disease: Part I. Pathogenesis and clinical manifestations of graft-versus-host disease. J Am Acad Dermatol 66(4):515.e1-515.e18, 2012. PMID: 22421123.
- Hymes SR, Alousi AM, Cowen EW. Graft-versus-host disease: Part II. Management of cutaneous graft-versus-host disease. J Am Acad Dermatol 66(4):535.e1-535.e16, 2012. PMID: 22421124.
- Anderlini P, Saliba RM, Ledesma C, Chancoco C, Alousi AM, Shpall EJ, Popat UR, Hosing CM, Khouri IF, Nieto Y, Ciurea S, Younes A, Fanale MA, Acholonu S, Valverde R, Champlin RE. Gemcitabine, fludarabine and melphalan (G-FM) as a reduced-intensity conditioning regimen for allogeneic stem cell transplantation in relapsed and refractory hodgkin lymphoma: preliminary results. Leuk Lymphoma 53(3):499-502, 2012. e-Pub 2011. PMID: 21859247.
- Ross WA, Alousi AM. Making the diagnosis of gastrointestinal GVHD: is evaluation of the ileum necessary?. Bone Marrow Transplant 47(3):321-2, 2012. PMID: 22395763.
- Popat U, de Lima MJ, Saliba RM, Anderlini P, Andersson BS, Alousi AM, Hosing C, Nieto Y, Parmar S, Khouri IF, Kebriaei P, Qazilbash M, Champlin RE, Giralt SA. Long-term outcome of reduced-intensity allogeneic hematopoietic SCT in patients with AML in CR. Bone Marrow Transplant 47(2):212-6, 2012. e-Pub 2011. PMID: 21423123.
- Alatrash G, Pelosini M, Saliba RM, Koca E, Rondon G, Andersson BS, Chiattone A, Zhang W, Giralt SA, Cernosek AM, Kebriaei P, Alousi AM, Popat UR, Hosing C, Khouri IF, Champlin RE, de Lima MJ. Platelet Recovery Prior to Allogeneic Stem Cell Transplant Predicts Posttransplant Outcomes in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome. Biol Blood Marrow Transplant 17(12):1841-5, 2011. e-Pub 2011. PMID: 21684343.
- Joseph RW, Alousi A, Konda B, Komanduri K, Neumann J, Trevino C, Stolar K, Qazilbash M, Hosing C, Kebriaei P, Couriel DR, Champlin RE, Saliba R, Popat U. High incidence of vitamin D deficiency in patients undergoing allogeneic stem cell transplantation. Am J Hematol 86(11):954-6, 2011. e-Pub 2011. PMID: 21948087.
- Kim HN, Alousi AM, Lee JH, Qiao W, Xiao L, Ross WA. Role of ERCP in patients after hematopoietic stem cell transplantation. Gastrointest Endosc 74(4):817-24, 2011. e-Pub 2011. PMID: 21802682.
- Parmar S, Andersson BS, Couriel D, Munsell MF, Fernandez-Vina M, Jones RB, Shpall EJ, Popat U, Anderlini P, Giralt S, Alousi A, Cano P, Bosque D, Hosing C, Silva Lde P, Westmoreland M, Wathen JK, Berry D, Champlin RE, de Lima MJ. Prophylaxis of Graft-Versus-Host Disease in Unrelated Donor Transplantation with Pentostatin, Tacrolimus, and "Mini"-Methotrexate: A Phase I/II Controlled, Adaptively Randomized Study. J Clin Oncol 29(3):294-302, 2011. e-Pub 2010. PMID: 21149654.
- Westin JR, Saliba RM, De Lima M, Alousi A, Hosing C, Qazilbash MH, Khouri IF, Shpall EJ, Anderlini P, Rondon G, Andersson BS, Champlin R, Couriel DR. Steroid-Refractory Acute GVHD: Predictors and Outcomes. Adv Hematol 2011:601953, 2011. e-Pub 2011. PMID: 22110505.
- Levine JE, Logan B, Wu J, Alousi AM, Ho V, Bolaños-Meade J, Weisdorf D, Blood and Marrow Transplant Clinical Trials Network. Graft-versus-Host Disease Treatment: Predictors of Survival. Biol Blood Marrow Transplant 16(12):1693-9, 2010. e-Pub 2010. PMID: 20541024.
- Jacobson PA, Huang J, Wu J, Kim M, Logan B, Alousi A, Grimley M, Bolaños-Meade J, Ho V, Levine JE, Weisdorf D. Mycophenolate Pharmacokinetics and Association with Response to Acute Graft vs Host Disease (GVHD) Treatment From the Blood and Marrow Transplant Clinical Trials Network. Biol Blood Marrow Transplant 16(3):421-9, 2010. e-Pub 2009. PMID: 19925875.
- Alousi AM, Uberti J, Ratanatharathorn V. The role of B cell depleting therapy in graft versus host disease after allogeneic hematopoietic cell transplant. Leuk Lymphoma 51(3):376-389, 2010. e-Pub 2010. PMID: 20141428.
- Couriel DR, Saliba R, de Lima M, Giralt S, Andersson B, Khouri I, Hosing C, Ippoliti C, Shpall EJ, Champlin R, Alousi A. A phase III study of infliximab and corticosteroids for the initial treatment of acute graft-versus-host disease. Biol Blood Marrow Transplant 15(12):1555-62, 2009. e-Pub 2009. PMID: 19896079.
- Alousi AM, Weisdorf DJ, Logan BR, Bolaños-Meade J, Carter S, Difronzo N, Pasquini M, Goldstein SC, Ho VT, Hayes-Lattin B, Wingard JR, Horowitz MM, Levine JE, Blood and Marrow Transplant Clinical Trials Network. Etanercept, mycophenolate, denileukin or pentostatin plus corticosteroids for acute graft vs. host disease: a randomized phase II trial from the BMT CTN. Blood 114(3):511-7, 2009. e-Pub 2009. PMID: 19443659.
- Tam CS, Bassett R, Ledesma C, Korbling M, Alousi A, Hosing C, Kebraei P, Harrell R, Rondon G, Giralt SA, Anderlini P, Popat U, Pro B, Samuels B, Hagemeister F, Medeiros LJ, Champlin RE, Khouri IF. Mature results of the MD Anderson Cancer Center risk-adapted transplantation strategy in mantle cell lymphoma. Blood 113(18):4144-52, 2009. e-Pub 2009. PMID: 19168784.
- Alousi AM, Saliba RM, Okoroji GJ, Macapinlac HA, Hosing C, Korbling M, Samuels BI, Popat U, Kebriaei P, Anderlini P, Qazilbash MH, de Lima M, Giralt SA, Champlin RE, Khouri IF. Disease staging with positron emission tomography or gallium scanning and use of rituximab predict outcome for patients with diffuse large B-cell lymphoma treated with autologous stem cell transplantation. Br J Haematol 142(5):786-92, 2008. e-Pub 2008. PMID: 18564354.
- Alousi A, de Lima M. Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation. Clin Adv Hematol Oncol 5(7):560-70, 2007. PMID: 17679930.
- Alousi AM, Boinpally R, Wiegand R, Parchment R, Gadgeel S, Heilbrun LK, Wozniak AJ, DeLuca P, LoRusso PM. A phase 1 trial of XK469: toxicity profile of a selective topoisomerase IIbeta inhibitor. Invest New Drugs 25(2):147-54, 2007. e-Pub 2006. PMID: 17103044.
Book Chapters
- Alousi A, de Lima M. Ablative Preparative Regimens. In: Stem Cell Transplantation for Hematologic and Other Disorders. 2nd. Humana Press, 2008.
- de Lima M, Alousi A, Giralt S. Preparative Regimens for Stem Cell Transplantation. In: Hematology: Basic Principals and Practice. 5th. Churchill Livingstone, 2008.
- Alousi AM, Giralt SA. Hematopoietic Progenitor Cells: Allogeneic. In: Rossi’s Principles of Transfusion Medicine. 4th. Wiley-Blackwell, 542-558, 2008.
- Alousi A. Graft-Versus-Host Disease: Prevention and Treatment / Transfusion Support. In: Supportive Care Manual for Blood and Marrow Transplantation. 1st. Summit: New York, 97-138; 171-183, 2007.
- Alousi A. Disseminated Intravascular Coagulation / Fever in the Neutropenic Patient. In: Pediatric Acute Care. 2nd. Lippincott Williams & Wilkins, 74-75; 82 and 84-85, 2001.
Grant & Contract Support
| Title: | Itacitinib Monotherapy for Low Risk Graft-Vs-Host Disease |
| Funding Source: | Icahn School of Medicine - Mt Sinai |
| Role: | Principal Investigator |
| Title: | A Randomized, Multicenter, Phase III Trial of Tacrolimus/Methotrexate versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation |
| Funding Source: | National Marrow Donor Program (1703/1801) |
| Role: | Principal Investigator |
| Title: | A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study To Evaluate The Safety And Efficacy Of Alpha-1 Antitrypsin For The Prevention Of Graft-Versus Host Disease In Patients Receiving Hematopoietic Cell Transplant (MODULAATE Study) |
| Funding Source: | CSL Behring |
| Role: | Principal Investigator |
| Title: | Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Cell Transplant Recipients |
| Funding Source: | Fred Hutchinson Cancer Center/ NHLBI |
| Role: | Co-Investigator |
Patient Reviews
CV information above last modified August 12, 2024