Andrea Viale, MD
Department of Genomic Medicine, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty Member, Graduate School of Biomedical Sciences, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty Member, Graduate School of Biomedical Sciences, Houston, TX
Education & Training
Degree-Granting Education
| 2004 | University of Turin, Turin, IT, Oncology, Diploma in Clinical Oncology (Residency) |
| 2000 | Medical School, University of Turin, Turin, IT, MD |
Postgraduate Training
| 2011-2011 | Biomarkers and Imaging in Drug Development, Harvard University, Boston, Massachusetts |
| 2010-2010 | Intensive Training in Translational Medicine, Harvard University, Boston, Massachusetts |
| 2009-2011 | Postdoctoral Fellowship, Dana-Farber Cancer Institute/Harvard University |
| 2004-2009 | Postdoctoral Fellowship, European Institute of Oncology, Milan |
| 2000-2004 | Residency in Clinical Oncology, University of Turin, Turin |
| 2000-2003 | Research Fellowship, Institute for Cancer Research and Treatment, Candiolo |
| 2000-2001 | Clinical Internship, Division of Clinical Oncology, Institute for Cancer Research and Treatment, Candiolo |
Licenses & Certifications
| 2018 | National Academic Qualification (ASN), Italy |
| 2004 | Diploma in Clinical Oncology |
| 2000 | Italian Medical Board |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2022
Instructor, Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2016
Administrative Appointments/Responsibilities
Chair, Overseas Joint Meetings, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2022 - Present
Co-Chair, Genomic Medicine and Cancer Biology Departmental Meetings, The University of Texas MD Anderson Cancer Center, Houston, 2016 - Present
Elected Member - Faculty Senate, The University of Texas MD Anderson Cancer Center, Houston, 2016 - 2022
Extramural Institutional Committee Activities
Member, Technology Task Force, The University of Texas MD Anderson Cancer Center, 2026 - Present
Member, Division of Cancer Medicine Faculty Recognition and Award Program, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, Research Misconduct Inquiry Committee, The University of Texas MD Anderson Cancer Center, 2025 - Present
Chair, Organizing Committee Second CRO Aviano – MD Anderson Symposium, The University of Texas MD Anderson Cancer Center, 2025
Member, Mid Term Faculty Evaluation, The University of Texas MD Anderson Cancer Center, 2024
Interviewer, GSBS applicant student interviewer, Graduate School of Biomedical Sciences, 2023 - Present
Chair, Organizing Committee for the Leading Edge of Cancer Research Symposium, The University of Texas MD Anderson Cancer Center, 2023
Organizing Member, Organizing Committee member and member of the faculty representing MD Anderson at the First CRO Aviano – MD Anderson, The University of Texas MD Anderson Cancer Center, 2023
Chair, Organizing Committee Overseas Joint Meeting Series, The University of Texas MD Anderson Cancer Center, 2022 - Present
Co-Chair, Organizing Committee for the Leading Edge of Cancer Research Symposium, The University of Texas MD Anderson Cancer Center, 2022
Member, GSBS Alfred G. Knudson Award Selection Panel, Graduate School of Biomedical Sciences, 2022
Interviewer, Vice President Research Recruitment, The University of Texas MD Anderson Cancer Center, 2022
Interviewer, Department of Systems Biology Chair Search, The University of Texas MD Anderson Cancer Center, 2022
Committee Member, Hematopoietic Biology & Malignancy Chair Search Committee, The University of Texas MD Anderson Cancer Center, 2021
Committee Member, Faculty Exam Committee for Graduate Students, Graduate School of Biomedical Sciences, 2020 - Present
Committee Member, Postdoc Recruitment Committee, The University of Texas MD Anderson Cancer Center, 2020
Committee Member, Research Ramp Up Working Group, The University of Texas MD Anderson Cancer Center, 2020
Committee Member, Faculty Advisory Committee for Graduate Students, Graduate School of Biomedical Sciences, 2019 - Present
Committee Member, Faculty Search Committee Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 2019
Committee Member, Faculty Search Committee Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 2019
Committee Member, Organizing/Reviewing Committee of Genomic Medicine Science Day, The University of Texas MD Anderson Cancer Center, 2018 - 2019
Honors & Awards
| 2022 | Wall of Science-excellence work recognition for PMID: 34529467, MD Anderson Cancer Center |
| 2022 | Recipient of President’s Recognition of Faculty Excellence, MD Anderson Cancer Center |
| 2022 | Wall of Science-excellence work recognition for PMID: 34039636, MD Anderson Cancer Center |
| 2020 | V Scholar Cancer Research Award |
| 2019 | Andrew Sabin Family Foundation Fellowship, MD Anderson Cancer Center |
| 2010 | Lorini Foundation Award for Cancer And HIV Research, Lorini Foundation |
| 2010 | Hirshberg Foundation for Pancreatic Cancer Research Seed Grant, Hirshberg Foundation |
| 2004 - 2009 | Postdoctoral Fellowship, Vollaro Foundation |
| 2000 - 2004 | Fellowship, Oncology Medical School, Turin, Italy |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2026. CCSG Gastrointestinal Program. Invited. Houston, Texas, US.
- 2025. Symposium on a Decade of Advances in Pancreatic Cancer Research & Clinical Care at the MD Anderson Cancer Center. Invited. Houston, Texas, US.
- 2024. Shelby-Lavine Symposium. Invited. Houston, Texas, US.
- 2024. System Biology Seminar Series. Invited. Houston, Texas, US.
- 2023. MIMIG Symposium. Invited. Houston, Texas, US.
- 2023. Pancreatic Cancer Research Seminar Series. Invited, US.
- 2023. Kopchick Research Symposium. Invited. Houston, Texas, US.
- 2022. Humanitas Research Hospital. Invited. Milan, IT.
- 2018. CCSG GI Program Retreat. Invited. Houston, Texas, US.
- 2016. Pancreatic Cancer Action Network: Pancreatic Cancer 2020. Invited. Pancreatic Cancer Action Network. Houston, Texas, US.
- 2015. XF Advanced Cell Metabolism in Cancer. Invited. Houston, Texas, US.
- 2014. DanStem. Copenhagen, DK.
- 2014. DKFZ, German Cancer Research Center. Invited. Heildelberg, DE.
- 2014. European Institute of Oncology. Invited. Milan, IT.
- 2014. Cancer Research UK. Invited. Cambridge, GB.
- 2014. Emil Freireich Institutional Ground Rounds. Invited. Houston, Texas, US.
National Presentations
- 2019. Symposium on Metabolism in Cancer. Invited. The University of Texas MD Anderson Cancer Center. Houston, Texas, US.
- 2018. The Banbury Center-CSHL, Autophagy and Cancer. Invited. CSHL. New York, NY, US.
- 2016. Symposium on Metabolism in Cancer. Invited. The University of Texas MD Anderson Cancer Center. Houston, Texas, US.
- 2015. Symposium on Metabolism in Cancer. Invited. The University of Texas MD Anderson Cancer Center. Houston, Texas, US.
- 2011. The Seventh Annual Agi Hirshberg Symposium for Pancreatic Cancer. Invited. UCLA. Los Angeles, CA, US.
International Presentations
- 2026. Hematopoietic Stem Cell and Myelodysplastic Syndromes Symposium. Invited. Houston, US.
- 2026. NCI Workshop: Understanding Plasticity and Its Role Across the Cancer Continuum. Invited. Rockville, US.
- 2023. First CRO-MD Anderson Symposium in Cancer Research. Invited. Pordenone, IT.
- 2023. MDACC-Princess Margaret Joint Symposium. Invited. Houston, US.
- 2023. American Association for Cancer Research, Annual Meeting. Conference. Orlando, US.
- 2023. European Association for Cancer Research, Annual Meeting. Invited. Turin, IT.
- 2022. Weizmann Institute-MD Anderson Symposium in Cancer Research. Invited. Rehovot, IL.
- 2022. American Pancreatic Association, Annual Meeting. Conference. Orlando, US.
- 2021. International Society for Cancer Metabolism 8th Annual Meeting. Invited. International Society for Cancer Metabolism. Padua, IT.
- 2021. 3rd International Conference on Aging and Cancer: the impact of aging on clonal evolution. Invited. 3rd International Conference on Aging and Cancer: the impact of aging on clonal evolution. Haikou, CN.
- 2019. Symposia on Cancer Research. Invited. The University of Texas MD Anderson Cancer Center. Houston, US.
- 2018. First Alumni Meeting, European Institute of Oncology. Invited. European Institute of Oncology, IT.
- 2018. AACR Annual Meeting, Reversing Drug Resistance. Conference. AACR. Chicago, US.
- 2016. 24th SFFRA Annual Meeting. Invited. SFFRA. Gold Coast, AU.
- 2016. Symposia on Cancer Research. Invited. The University of Texas MD Anderson Cancer Center. Houston, US.
- 2015. AACR Annual Meeting, Cancer Stem Cell Symposium. Conference. AACR. Philadelphia, US.
- 2014. Pancreatic Cancer: Innovation in Research and Treatment. Conference. AACR. New Orleans, US.
- 2009. Hematology. Invited. SIES. Florence, IT.
- 2009. From leukemic cell biology to new therapeutic approaches. Invited. From leukemic cell biology to new therapeutic approaches.
- 2008. Stem Cell Biology. Invited. EMBO. Banz Monastery, DE.
- 2007. AMLs from Bench to Bedside. Invited. AMLs from Bench to Bedside.
- 2005. Cancer Stem Cells. Invited. International Workshop on Cancer Stem Cells. Milan, IT.
Grant & Contract Support
| Date: | 2026 - 2029 |
| Title: | CROSSROADS: cross-tissue regeneration aberrancy drives systemic precancer escape |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| ID: | BDP-FY27-02 |
| Date: | 2026 - 2028 |
| Title: | Alternating Clonal Dominance and Local Microenvironment Evolution at the Primary Tumor Site as Key Drivers of Metastatic Dissemination in Pancreatic Cancer |
| Funding Source: | U.S. Department of Defense |
| Role: | PI |
| ID: | CA250849 |
| Date: | 2026 - 2028 |
| Title: | Intergenerational effects of paternal obesity on lung immune dysregulation and tumorigenesis |
| Funding Source: | Cancer Prevention and Research Institute of Texas |
| Role: | PI |
| ID: | RP260829 |
| Date: | 2025 - 2028 |
| Title: | Dissecting the molecular mechanisms underlying epithelial memory and pancreatic cancer progression |
| Funding Source: | Cancer Prevention Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP230373 |
| Date: | 2025 - 2029 |
| Title: | EMPATHIC: Environmental Microplastics and systemic PATHology, Inflammation and Carcinogenesis |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| ID: | RCTS 00065428 |
| Date: | 2025 - 2026 |
| Title: | Dissecting clonal and microenvironmental evolution during pancreatic tumor dissemination |
| Funding Source: | Institutional Research Grant |
| Role: | PI |
| Date: | 2023 - 2025 |
| Title: | Body care products, cell reprogramming, and melanoma development |
| Funding Source: | Permanent Health Funds |
| Role: | PI |
| ID: | 1601968 |
| Date: | 2023 - 2026 |
| Title: | Mapping the Geospatial Tumor Clonal Architecture to Restore Immune Recognition in Pancreatic Cancer |
| Funding Source: | Cancer Prevention Research Institute of Texas |
| Role: | PI |
| ID: | RP230373 |
| Date: | 2021 - 2026 |
| Title: | Mitochondrial heterogeneity as the origin of chemoresistance in pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA258917 |
| Date: | 2020 - 2022 |
| Title: | Contribution of tumor heterogeneity in eliciting response to the immune system |
| Funding Source: | V Foundation |
| Role: | PI |
| ID: | V2020-018 |
| Date: | 2020 - 2021 |
| Title: | Define biomarker of progression and modalities to prevent pancreatic cancer |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2019 - 2021 |
| Title: | Epithelial memory of resolved inflammation as a driver of pancreatic cancer progression |
| Funding Source: | Cancer Prevention Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | FP00007338 |
| Date: | 2019 - 2024 |
| Title: | MD Anderson Cancer Center SPORE in Gastrointestinal Cancer – Project 3 |
| Funding Source: | NIH/NCI |
| Role: | Project Leader |
| ID: | P50CA221707-01A1 |
| Date: | 2019 - 2021 |
| Title: | Inducers of acinar ductal metaplasia as a new therapeutic strategy to cure pancreatitis and prevent pancreatic cancer |
| Funding Source: | Andrew Sabin Family Fellows |
| Role: | PI |
| ID: | 00057021 |
| Date: | 2018 - 2023 |
| Title: | Medium-chain acyl-coenzyme A dehydrogenase as an essential feeder of glioblastoma multiforme |
| Funding Source: | National Institute of Health |
| Role: | Collaborator |
| ID: | R01CA218139-01A1 |
| Date: | 2016 - 2021 |
| Title: | Genetics and Biology of Pancreatic Ductal Adenocarcinoma |
| Funding Source: | National Institute of Health |
| Role: | Co-I |
| ID: | 2 P01 CA117969-12 |
| Date: | 2016 - 2019 |
| Title: | Identifying new epigenetic vulnerabilities in pancreatic cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP160471 |
| Date: | 2014 - 2016 |
| Title: | The Nexus of Epigenetics and Immune-oncology |
| Funding Source: | Department of Defense (DOD) |
| Role: | Collaborator |
| Date: | 2014 - 2017 |
| Title: | Developing a novel oxidative phosphorylation inhibitor in pancreatic cancer |
| Funding Source: | PanCAN |
| Role: | Co-I |
| ID: | 14-90-25-DRAE |
| Date: | 2013 - 2016 |
| Title: | Eradication of treatment-resistant pancreatic cancer stem cells |
| Funding Source: | UTMDACC Khalifa Bin Zayed Al Nahyan Center for Pancreatic Cancer Research |
| Role: | Co-PI |
| Date: | 2010 - 2011 |
| Title: | Role of Oncogenic K-RAS in Self-renewal and Maintenance of Cancer Stem Cells in Pancreatic Tumor |
| Funding Source: | Hirshberg Foundation for Pancreatic Cancer Research |
| Role: | PI |
| Date: | 2010 - 2012 |
| Title: | No title provided |
| Funding Source: | Harvard Stem Cell Institute |
| Role: | Co-I |
Selected Publications
Peer-Reviewed Articles
- Yen E, Ho I, Chen K, Liu Z, Li CY, Citron F, Wang F, Jiang S, Shah R, Dyke CA, Attanasio S, Cecchetto L, Granato E, Kwon JH, Sainani S, Castillo LA, Kugeratski FG, Chang J, Pan J, Del Poggetto E, Peoples M, Jiang H, Singh S, Joon AY, Ying H, Genovese G, Carugo A, Giuliani V, Yee C, Di Pilato M, Futreal AP, Draetta GF, Viale A. Recurrent shallow deletion orchestrates spatial immune exclusion and immune checkpoint blockade resistance in cancer. Science. e-Pub 2026.
- Ho I, Shah R, Liu Z, Wong MC, Kwon JH, Yen E, Dyke CA, Citron F, Jayabalan R, Gonzalez-Delgado R, Damania A, Attanasio S, Cecchetto L, Granato E, Chen Z, Zal MA, Yang H, Cassasent A, Jiang S, Min J, Martinez AH, Ramamoorthy V, Peoples M, Daniele JR, Ying H, Giuliani V, Perelli L, Genovese G, Maitra A, Jeter C, Heffernan T, Wargo J, Di Pilato M, Navin N, Van Loo P, Draetta GF, Futreal AP, Ajami AJ, Viale A. Physiological aneuploidy as a result of asynthetic reductive divisions during damage repair in the pancreas. Gut. e-Pub 2026.
- Attanasio S, Citron F, Shah R, Saj F, Liu Z, Ho I, Yen E, Xiao L, Dyke C, Kwon HJ, Cecchetto L, Chen Z, Granato E, Sainani S, Loponte S, Chu Y, Soeung M, Perelli L, Jiang S, Dutta P, Bhattacharya P, Wang H, Wang L, Kim M, Genovese G, Lyssiotis CA, Welsch D, Menter D, Draetta GF, Kopetz S, Maitra A, Pant S, Viale A. Targeting mitochondrial complex I overcomes adaptive response to chemotherapy: a preclinical and phase Ib study in advanced pancreatic cancer. Gut. e-Pub 2026.
- Citron F, Cecchetto L, Granato E, Ho IL, Liu Z, Balestrieri C, Yen EY, Perelli L, Zhang L, Castillo Montanez LA, Dyke CA, Shah R, Attanasio S, Srinivasan S, Roy S, Kwon HJ, Blazanin N, Chen Y, Chen KC, Chen Z, Scognamiglio I, Pham N, Jiang S, Pan J, Leung CS, Wang L, Gao S, Carugo A, Wang H, Yao W, Tonon G, Bonini MC, Zal MA, Jeter C, Tainer JA, Heffernan TP, Giuliani V, Lissanu Y, Genovese G, Di Pilato M, Viale A, Schlacher K, Draetta GF. DPY30 Is an Epigenetic Decoupler Linking Replication Stress to Immunoediting in Pancreatic Cancer. Cancer Research 86(12), 2026. e-Pub 2026. PMID: 41941748.
- Wei Y, # ML, Yen E, # JY, Xun Z, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Li C, Theardy MS, Park J, Cai Y, Takeda M, Vasquez M, Park EM, Peng DH, Zhou Y, Zhao H, Heffernan TP, Viale A, Wang H, Watowich SS, Liang H, Zhao D, DePinho RA, Yao W, Ying H. KRAS Inhibition Activates an Actionable CD24 "Do Not Eat Me" Signal in Pancreatic Cancer. Cancer Research, 2025. e-Pub 2025. PMID: 40966362.
- Chen Z, Ho IL, Liu J, Soeung M, Yen EY, Sainani S, Dyke CA, Shah R, Kwon HJ, Han G, Yan X, Zhang S, Srinivasan S, Rose JL, Citron F, Jiang S, Chang Q, Feng N, Genovese G, Gao S, Yao W, Wang L, Wang H, Ying H, Viale A, Draetta GF. GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma. Cancer Research, 2025. e-Pub 2025. PMID: 41329747.
- Soeung M, Yan X, Zanca C, Qian J, Karki M, Duan F, Khan H, Zhang L, Peng DH, Williams M, He R, Chen Z, Perelli L, Chen J, Tidwell RS, Chauhan PK, Le CN, Lam TNA, Bhattacharya N, Shah R, Ho IL, Gay JP, Carrillo CC, Feng N, Le K, Gao G, Perry TL, Mseeh F, Jiang Y, Xu QA, Zacharias NM, Sheth RA, Bathala TK, Rao P, Daw NC, Tripathi DN, Walker CL, Mohammad MM, Zhang J, Han G, Chu Y, Wang R, Dang M, Dai E, Peng F, Liu Y, Jadhav A, Lang W, Arrechedera CA, Clemente LC, Parra ER, Lu H, Haymaker CL, Wistuba II, Futreal A, Viale A, Soth MJ, Jones P, Marszalek JR, Heffernan T, Draetta GF, Tannir NM, Gao J, Wang L, Genovese G, Msaouel P. Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence. Nature Communications, 2025. e-Pub 2025. PMID: 41290625.
- Perelli L, Zhang L, Mangiameli S, Giannese F, Mahadevan KK, Peng F, Citron F, Khan H, Le C, Gurreri E, Carbone F, C Russell AJ, Soeung M, Anh Lam TN, Lundgren S, Marisetty S, Zhu C, Catania D, T Mohamed AM, Feng N, Augustine JJ, Sgambato A, Tortora G, Draetta GF, Tonon G, Futreal A, Giuliani V, Carugo A, Viale A, Kim MP, Heffernan TP, Wang L, Kalluri R, Cittaro D, Chen F, Genovese G. Evolutionary fingerprints of epithelial-to-mesenchymal transition. Nature, 2025. e-Pub 2025. PMID: 40044861.
- Ho, IL, Li, CY, Wang, F, Zhao, L, Liu, J, Yen, EY, Dyke, CA, Shah, R, Liu, Z, Çetin, AO, Chu, Y, Citron, F, Attanasio, S, Corti, D, Darbaniyan, F, Del Poggetto, E, Loponte, S, Liu, J, Soeung, M, Chen, Z, Jiang, S, Jiang, H, Inoue, A, Gao, S, Deem, AK, Feng, N, Ying, H, Kim, M, Giuliani, V, Genovese, G, Zhang, J, Futreal, A, Maitra, A, Heffernan, TP, Wang, L, Do, K, Gargiulo, G, Draetta, G, Carugo, A, Lin, R, Viale, A. Clonal dominance defines metastatic dissemination in pancreatic cancer. Science Advances 10(11), 2024. e-Pub 2024. PMID: 38478609.
- Cortesi, A, Gandolfi, F, Arco, F, Chiaro, PD, Valli, E, Polletti, S, Noberini, R, Gualdrini, F, Attanasio, S, Citron, F, Ho, IL, Shah, R, Yen, EY, Spinella, MC, Ronzoni, S, Rodighiero, S, Mitro, N, Bonaldi, T, Ghisletti, S, Monticelli, S, Viale, A, Diaferia, GR, Natoli, G. Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer. Science Advances 10(13), 2024. e-Pub 2024. PMID: 38536927.
- Thongon N, Ma F, Baran N, Lockyer P, Liu J, Jackson C, Rose A, Furudate K, Wildeman B, Marchesini M, Marchica V, Storti P, Todaro G, Ganan-Gomez I, Adema V, Rodriguez-Sevilla JJ, Qing Y, Ha MJ, Fonseca R, Stein C, Class C, Tan L, Attanasio S, Garcia-Manero G, Giuliani N, Berrios Nolasco D, Santoni A, Cerchione C, Bueso-Ramos C, Konopleva M, Lorenzi P, Takahashi K, Manasanch E, Sammarelli G, Kanagal-Shamanna R, Viale A, Chesi M, Colla S. Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma. Nature Communications 15(1):1203, 2024. e-Pub 2024. PMID: 38331987.
- Chen, Z, Ho, IL, Soeung, M, Yen, EY, Liu, J, Yan, L, Rose, J, Srinivasan, S, Jiang, S, Chang, Q, Feng, N, Gay, J, Wang, Q, Wang, J, Lorenzi, PL, Veillon, L, Wei, B, Weinstein, JN, Deem, AK, Gao, S, Genovese, G, Viale, A, Yao, W, Lyssiotis, CA, Marszalek, JR, Draetta, G, Ying, H. Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis. Nature Communications 14(1), 2023. e-Pub 2023. PMID: 37069167.
- Perelli L, Carbone F, Zhang L, Huang JK, Le C, Khan H, Citron F, Del Poggetto E, Gutschner T, Tomihara H, Soeung M, Minelli R, Srinivasan S, Peoples M, Lam TNA, Lundgren S, Xia R, Zhu C, Mohamed AMT, Zhang J, Sircar K, Sgambato A, Gao J, Jonasch E, Draetta GF, Futreal A, Bakouny Z, Van Allen EM, Choueiri T, Signoretti S, Msaouel P, Litchfield K, Turajlic S, Wang L, Chen YB, Di Natale RG, Hakimi AA, Giuliani V, Heffernan TP, Viale A, Bristow CA, Tannir NM, Carugo A, Genovese G. Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer. Nature Cancer 4(7):984-1000, 2023. e-Pub 2023. PMID: 37365326.
- Soeung, M, Perelli, L, Chen, Z, Dondossola, E, Ho, IL, Carbone, F, Zhang, L, Khan, H, Le, C, Zhu, C, Peoples, M, Feng, N, Jiang, S, Millward, NZ, Minelli, R, Shapiro, DD, Deem, AK, Gao, S, Cheng, EH, Lucchetti, D, Walker, CL, Carugo, A, Giuliani, V, Heffernan, TP, Viale, A, Tannir, NM, Draetta, G, Msaouel, P, Genovese, G. SMARCB1 regulates the hypoxic stress response in sickle cell trait. PNAS 120(21), 2023. e-Pub 2023. PMID: 37186844.
- Cao S, Wang JR, Ji S, Yang P, Dai Y, Guo S, Montierth MD, Shen JP, Zhao X, Chen J, Lee JJ, Guerrero PA, Spetsieris N, Engedal N, Taavitsainen S, Yu K, Livingstone J, Bhandari V, Hubert SM, Daw NC, Futreal PA, Efstathiou E, Lim B, Viale A, Zhang J, Nykter M, Czerniak BA, Brown PH, Swanton C, Msaouel P, Maitra A, Kopetz S, Campbell P, Speed TP, Boutros PC, Zhu H, Urbanucci A, Demeulemeester J, Van Loo P, Wang W. Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. Nature Biotechnology 40(11):1624-1633, 2022. e-Pub 2022. PMID: 35697807.
- Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA. Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells. Nature Cancer 3(11):1386-1403, 2022. e-Pub 2022. PMID: 36411320.
- Puca F, Yu F, Bartolacci C, Pettazzoni P, Carugo A, Huang-Hobbs E, Liu J, Zanca C, Carbone F, Del Poggetto E, Gumin J, Dasgupta P, Seth S, Srinivasan S, Lang FF, Sulman EP, Lorenzi PL, Tan L, Shan M, Tolstyka ZP, Kachman M, Zhang L, Gao S, Deem AK, Genovese G, Scaglioni PP, Lyssiotis CA, Viale A, Draetta GF. Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma. Cancer Discovery 11(11):2904-2923, 2021. e-Pub 2021. PMID: 34039636.
- Del Poggetto E, Ho IL, Balestrieri C, Yen EY, Zhang S, Citron F, Shah R, Corti D, Diaferia GR, Li CY, Loponte S, Carbone F, Hayakawa Y, Valenti G, Jiang S, Sapio L, Jiang H, Dey P, Gao S, Deem AK, Rose-John S, Yao W, Ying H, Rhim AD, Genovese G, Heffernan TP, Maitra A, Wang TC, Wang L, Draetta GF, Carugo A, Natoli G, Viale A. Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science 373(6561):eabj0486, 2021. e-Pub 2021. PMID: 34529467.
- Giuliani V, Miller MA, Liu CY, Hartono SR, Class CA, Bristow CA, Suzuki E, Sanz LA, Gao G, Gay JP, Feng N, Rose JL, Tomihara H, Daniele JR, Peoples MD, Bardenhagen JP, Geck Do MK, Chang QE, Vangamudi B, Vellano C, Ying H, Deem AK, Do KA, Genovese G, Marszalek JR, Kovacs JJ, Kim M, Fleming JB, Guccione E, Viale A, Maitra A, Emilia Di Francesco M, Yap TA, Jones P, Draetta G, Carugo A, Chedin F, Heffernan TP. PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nature Communications 12(1):4626, 2021. e-Pub 2021. PMID: 34330913.
- Citron F, Segatto I, Musco L, Pellarin I, Rampioni Vinciguerra GL, Franchin G, Fanetti G, Miccichè F, Giacomarra V, Lupato V, Favero A, Concina I, Srinivasan S, Avanzo M, Castiglioni I, Barzan L, Sulfaro S, Petrone G, Viale A, Draetta GF, Vecchione A, Belletti B, Baldassarre G. miR-9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC. EMBO Mol Med 13(7):e12872, 2021. e-Pub 2021. PMID: 34062049.
- Inoue A, Robinson FS, Minelli R, Tomihara H, Rizi BS, Rose JL, Kodama T, Srinivasan S, Harris AL, Zuniga AM, Mullinax RA, Ma X, Seth S, Daniele JR, Peoples MD, Loponte S, Akdemir KC, Khor TO, Feng N, Roszik J, Sobieski MM, Brunell D, Stephan C, Giuliani V, Deem AK, Shingu T, Deribe YL, Menter DG, Heffernan TP, Viale A, Bristow CA, Kopetz S, Draetta GF, Genovese G, Carugo A. Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer. Gastroenterology 161(1):196-210, 2021. e-Pub 2021. PMID: 33745946.
- Tomihara H, Carbone F, Perelli L, Huang JK, Soeung M, Rose JL, Robinson FS, Lissanu Deribe Y, Feng N, Takeda M, Inoue A, Poggetto ED, Deem AK, Maitra A, Msaouel P, Tannir NM, Draetta GF, Viale A, Heffernan TP, Bristow CA, Carugo A, Genovese G. Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress. Cancer Research 81(2):332-343, 2021. e-Pub 2021. PMID: 33158812.
- Citron F, Perelli L, Deem AK, Genovese G, Viale A. Leukotrienes, a potential target for Covid-19. Prostaglandins Leukot Essent Fatty Acids 161:102174, 2020. e-Pub 2020. PMID: 32977289.
- Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer. Cell 179(5):1239, 2019. e-Pub 2019. PMID: 31730860.
- Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature 568(7752):410-414, 2019. e-Pub 2019. PMID: 30918400.
- Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell 35(2):204-220.e9, 2019. e-Pub 2019. PMID: 30753823.
- Seth S, Li CY, Ho IL, Corti D, Loponte S, Sapio L, Del Poggetto E, Yen EY, Robinson FS, Peoples M, Karpinets T, Deem AK, Kumar T, Song X, Jiang S, Kang Y, Fleming J, Kim M, Zhang J, Maitra A, Heffernan TP, Giuliani V, Genovese G, Futreal A, Draetta GF, Carugo A, Viale A. Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors. Cell Reports 26(6):1518-1532.e9, 2019. e-Pub 2019. PMID: 30726735.
- Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Sgambato A, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature 542(7641):362-366, 2017. e-Pub 2017. PMID: 28178232.
- Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature 542(7639):119-123, 2017. e-Pub 2017. PMID: 28099419.
- Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Reports 16(1):133-47, 2016. e-Pub 2016. PMID: 27320920.
- Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222, 2016. e-Pub 2016. PMID: 26799652.
- Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estecio M, Weksberg DC, Ho YW, Hu B, Genovese G, Pettazzoni P, Multani AS, Jiang S, Hua S, Ryan MC, Carugo A, Nezi L, Wei Y, Yang H, D'Anca M, Zhang L, Gaddis S, Gong T, Horner JW, Heffernan TP, Jones P, Cooper LJ, Liang H, Kantarjian H, Wang YA, Chin L, Bueso-Ramos C, Garcia-Manero G, DePinho RA. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell 27(5):644-57, 2015. e-Pub 2015. PMID: 25965571.
- Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, Kapoor A, Yao W, Francesco ME, Petrocchi A, Deem AK, Scott K, Colla S, Mills GB, Fleming JB, Heffernan TP, Jones P, Toniatti C, DePinho RA, Draetta GF. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Research 75(6):1091-101, 2015. e-Pub 2015. PMID: 25736685.
- Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514(7524):628-32, 2014. e-Pub 2014. PMID: 25119024.
- Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer. Cell 158(1):185-97, 2014. e-Pub 2014. PMID: 24954535.
- Campaner S, Viale A, De Fazio S, Doni M, De Franco F, D'Artista L, Sardella D, Pelicci PG, Amati B. A non-redundant function of cyclin E1 in hematopoietic stem cells. Cell Cycle 12(23):3663-72, 2013. e-Pub 2013. PMID: 24091730.
- Mallardo M, Caronno A, Pruneri G, Raviele PR, Viale A, Pelicci PG, Colombo E. NPMc+ and FLT3_ITD mutations cooperate in inducing acute leukaemia in a novel mouse model. Leukemia 27(11):2248-51, 2013. e-Pub 2013. PMID: 23584564.
- Insinga A, Cicalese A, Faretta M, Gallo B, Albano L, Ronzoni S, Furia L, Viale A, Pelicci PG. DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions. PNAS 110(10):3931-6, 2013. e-Pub 2013. PMID: 23417300.
- Martin-Padura I, Marighetti P, Gregato G, Agliano A, Malazzi O, Mancuso P, Pruneri G, Viale A, Bertolini F. Spontaneous cell fusion of acute leukemia cells and macrophages observed in cells with leukemic potential. Neoplasia 14(11):1057-66, 2012. e-Pub 2012. PMID: 23226099.
- Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149(3):656-70, 2012. e-Pub 2012. PMID: 22541435.
- Occhionorelli M, Santoro F, Pallavicini I, Gruszka A, Moretti S, Bossi D, Viale A, Shing D, Ronzoni S, Muradore I, Soncini M, Pruneri G, Rafaniello P, Viale G, Pelicci PG, Minucci S. The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha. Leukemia 25(5):814-20, 2011. e-Pub 2011. PMID: 21331069.
- Belloni E, Shing D, Tapinassi C, Viale A, Mancuso P, Malazzi O, Gerbino E, Dall'Olio V, Egurbide I, Odero MD, Bertolini F, Pelicci PG, Giuseppe Pelicci P. In vivo expression of an aberrant MYB-GATA1 fusion induces leukemia in the presence of GATA1 reduced levels. Leukemia 25(4):733-6, 2011. e-Pub 2011. PMID: 21252985.
- Viale A, De Franco F, Orleth A, Cambiaghi V, Giuliani V, Bossi D, Ronchini C, Ronzoni S, Muradore I, Monestiroli S, Gobbi A, Alcalay M, Minucci S, Pelicci PG. Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature 457(7225):51-6, 2009. e-Pub 2009. PMID: 19122635.
- Colucci S, Taraboletti G, Primo L, Viale A, Roca C, Valdembri D, Geuna M, Pagano M, Grano M, Pogrel AM, Harris AL, Athanasou NN, Mantovani A, Zallone A, Bussolino F. Gorham-Stout syndrome: a monocyte-mediated cytokine propelled disease. J Bone Miner Res 21(2):207-18, 2006. e-Pub 2006. PMID: 16418776.
- Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, Altucci L, Nervi C, Minucci S, Pelicci PG. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nature Medicine 11(1):71-6, 2005. e-Pub 2005. PMID: 15619634.
- Droetto S, Viale A, Primo L, Jordaney N, Bruno S, Pagano M, Piacibello W, Bussolino F, Aglietta M. Vasculogenic potential of long term repopulating cord blood progenitors. FASEB J 18(11):1273-5, 2004. e-Pub 2004. PMID: 15208264.
- Piacibello W, Bruno S, Sanavio F, Droetto S, Gunetti M, Ailles L, Santoni de Sio F, Viale A, Gammaitoni L, Lombardo A, Naldini L, Aglietta M. Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice. Nonobese diabetic/severe combined immunodeficient. Blood 100(13):4391-400, 2002. e-Pub 2002. PMID: 12453876.
- Leone F, Perissinotto E, Viale A, Cavalloni G, Taraglio S, Capaldi A, Piacibello W, Torchio B, Aglietta M. Detection of breast cancer cell contamination in leukapheresis product by real-time quantitative polymerase chain reaction. Bone Marrow Transplant 27(5):517-23, 2001. e-Pub 2001. PMID: 11313686.
Invited Articles
- Loponte S, Lovisa S, Deem AK, Carugo A, Viale A. The Many Facets of Tumor Heterogeneity: Is Metabolism Lagging Behind?. Cancers 11(10), 2019. e-Pub 2019. PMID: 31623133.
- Viale A, Draetta GF. Sugar? No thank you, just a deep breath of oxygen for cancer stem cells. Cell Metabolism 22(22):543-5, 2015. e-Pub 2015. PMID: 26445511.
- Viale A, Corti D, Draetta GF. Tumors and mitochondrial respiration: a neglected connection. Cancer Research 75(18):3685-6, 2015. e-Pub 2015. PMID: 26374463.
- Viale A, Pelicci PG. Awaking stem cells from dormancy: growing old and fighting cancer. EMBO Molecular Medicine 1(2):88-91, 2009. e-Pub 2009.
Book Chapters
- Viale A, Draetta GF. Metabolic features of cancer treatment resistance. In: Metabolism in Cancer. Ed(s) Cramer Thorsten, Schmitt Clemens, 2017.
- Viale A, Pelicci PG. Regulation of self-renewing division in normal and leukaemia stem cells. In: Cell cycle deregulation in cancer. Springer, 2010.
Patents
- Compositions and Methods for the Treatment of Cancer. Patent Number: 63/744,068.
- The use of ADM pharmacological inducers to treat pancreatitis and prevent pancreatic cancer. Patent Number: PCT/US2021/033024.
Patient Reviews
CV information above last modified August 28, 2026