Angela Ting, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Adjunct Associate Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
Education & Training
Degree-Granting Education
| 2005 | Johns Hopkins University School of Medicine, Baltimore, MD, USA, PHD, Cellular and Molecular Medicine |
| 2001 | University of British Columbia, Vancouver, CAN, BS, Genetics with Honors |
Postgraduate Training
| 2005-2007 | Postdoctoral Fellow, Johns Hopkins University School of Medicine, Baltimore, MD |
Selected Publications
Peer-Reviewed Articles
- Qiu H, Makarov V, Bolzenius JK, Halstead A, Parker Y, Wang A, Iyer GV, Wise H, Kim D, Thayaparan V, Lindner DJ, Haber GP, Ting AH, Ren B, Chan TA, Arora V, Solit DB, Lee BH. KDM6A loss triggers an epigenetic switch that disrupts urothelial differentiation and drives cell proliferation in bladder cancer. Cancer Res 83(6):814-829, 2023. e-Pub 2023. PMID: 36638328.
- Fink EE, Sona S, Lee BH, Ting AH. Processing and cryopreservation of human ureter tissues for single-cell and spatial transcriptomics assays. STAR Protoc 3(4):101854, 2022. e-Pub 2022. PMID: 36595885.
- Fink EE, Sona S, Tran U, Desprez PE, Bradley M, Qiu H, Eltemamy M, Wee A, Wolkov M, Nicolas M, Min B, Haber GP, Wessely O, Lee BH, Ting AH. Single-cell and spatial mapping Identify cell types and signaling Networks in the human ureter. Dev Cell 57(15):1899-1916.e6, 2022. e-Pub 2022. PMID: 35914526.
- Nanavaty V, Abrash EW, Hong C, Park S, Fink EE, Li Z, Sweet TJ, Bhasin JM, Singuri S, Lee BH, Hwang TH, Ting AH. DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex. Mol Cell 78(4):752-764.e6, 2020. e-Pub 2020. PMID: 32333838.
- Liang J, Zhou W, Sakre N, DeVecchio J, Ferrandon S, Ting AH, Bao S, Bissett I, Church J, Kalady MF. Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers. Br J Cancer 119(10):1267-1277, 2018. e-Pub 2018. PMID: 30318507.
- Sarvestani SK, Signs SA, Lefebvre V, Mack S, Ni Y, Morton A, Chan ER, Li X, Fox P, Ting A, Kalady MF, Cruise M, Ashburn J, Stiene J, Lai W, Liska D, Xiang S, Huang EH. Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids. Oncotarget 9(47):28717-28730, 2018. e-Pub 2018. PMID: 29983891.
- Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH, Vignali DAA, Stohlman SA, Baldwin WM, Min B. Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc Natl Acad Sci U S A 114(38):10190-10195, 2017. e-Pub 2017. PMID: 28874534.
- Bhasin JM, Ting AH. Goldmine integrates information placing genomic ranges into meaningful biological contexts. Nucleic Acids Res 44(12):5550-6, 2016. e-Pub 2016. PMID: 27257071.
- Yan H, Tang G, Wang H, Hao L, He T, Sun X, Ting AH, Deng A, Sun S. DNA methylation reactivates GAD1 expression in cancer by preventing CTCF-mediated polycomb repressive complex 2 recruitment. Oncogene 35(30):3995-4008, 2016. e-Pub 2015. PMID: 26549033.
- Bhasin JM, Hu B, Ting AH. MethylAction: detecting differentially methylated regions that distinguish biological subtypes. Nucleic Acids Res 44(1):106-16, 2016. e-Pub 2015. PMID: 26673711.
- Sadler T, Bhasin JM, Xu Y, Barnholz-Sloan J, Chen Y, Ting AH, Stylianou E. Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn's disease-associated fibrosis. Clin Epigenetics 8:30, 2016. e-Pub 2016. PMID: 26973718.
- Bhasin JM, Lee BH, Matkin L, Taylor MG, Hu B, Xu Y, Magi-Galluzzi C, Klein EA, Ting AH. Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer. Cell Rep 13(10):2135-46, 2015. e-Pub 2015. PMID: 26628371.
- Al-Harbi S, Choudhary GS, Ebron JS, Hill BT, Vivekanathan N, Ting AH, Radivoyevitch T, Smith MR, Shukla GC, Almasan A. miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies. Mol Cancer 14:185, 2015. e-Pub 2015. PMID: 26537004.
- Hu K, Ting AH, Li J. BSPAT: a fast online tool for DNA methylation co-occurrence pattern analysis based on high-throughput bisulfite sequencing data. BMC Bioinformatics 16:220, 2015. e-Pub 2015. PMID: 26163275.
- Kim JG, Kim TO, Bae JH, Shim JW, Kang MJ, Yang K, Ting AH, Yi JM. Epigenetically regulated MIR941 and MIR1247 target gastric cancer cell growth and migration. Epigenetics 9(7):1018-30, 2014. e-Pub 2014. PMID: 24785261.
- Hu B, Ji Y, Xu Y, Ting AH. Screening for SNPs with Allele-Specific Methylation based on Next-Generation Sequencing Data. Stat Biosci 5(1):179-197, 2013. PMID: 23710259.
- Lee BH, Taylor MG, Robinet P, Smith JD, Schweitzer J, Sehayek E, Falzarano SM, Magi-Galluzzi C, Klein EA, Ting AH. Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1. Cancer Res 73(3):1211-8, 2013. e-Pub 2012. PMID: 23233737.
- Xu Y, Hu B, Choi AJ, Gopalan B, Lee BH, Kalady MF, Church JM, Ting AH. Unique DNA methylome profiles in CpG island methylator phenotype colon cancers. Genome Res 22(2):283-91, 2012. e-Pub 2011. PMID: 21990380.
- Ginsberg MR, Rubin RA, Falcone T, Ting AH, Natowicz MR. Brain transcriptional and epigenetic associations with autism. PLoS One 7(9):e44736, 2012. e-Pub 2012. PMID: 22984548.
- Yan H, Choi AJ, Lee BH, Ting AH. Identification and functional analysis of epigenetically silenced microRNAs in colorectal cancer cells. PLoS One 6(6):e20628, 2011. e-Pub 2011. PMID: 21698188.
- Messick CA, Church JM, Liu X, Ting AH, Kalady MF. Stage III colorectal cancer: molecular disparity between primary cancers and lymph node metastases. Ann Surg Oncol 17(2):425-31, 2010. e-Pub 2009. PMID: 19885699.
- Serre D, Lee BH, Ting AH. MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic Acids Res 38(2):391-9, 2010. e-Pub 2009. PMID: 19906696.
- Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB. A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. Cancer Res 68(8):2570-5, 2008. PMID: 18413723.
- Winter JM, Ting AH, Vilardell F, Gallmeier E, Baylin SB, Hruban RH, Kern SE, Iacobuzio-Donahue CA. Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res 14(2):412-8, 2008. PMID: 18223216.
- Schuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB. Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet 3(9):1709-23, 2007. e-Pub 2007. PMID: 17892325.
- Jair KW, Bachman KE, Suzuki H, Ting AH, Rhee I, Yen RW, Baylin SB, Schuebel KE. De novo CpG island methylation in human cancer cells. Cancer Res 66(2):682-92, 2006. PMID: 16423997.
- Ting AH, Jair KW, Schuebel KE, Baylin SB. Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation. Cancer Res 66(2):729-35, 2006. PMID: 16424002.
- Ting AH, Schuebel KE, Herman JG, Baylin SB. Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat Genet 37(8):906-10, 2005. e-Pub 2005. PMID: 16025112.
- Ting AH, Jair KW, Suzuki H, Yen RW, Baylin SB, Schuebel KE. CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1. Nat Genet 36(6):582-4, 2004. e-Pub 2004. PMID: 15156141.
Patient Reviews
CV information above last modified January 31, 2024