Arjun Bhattacharya

Peer-Reviewed Articles

1. Venkateswaran, V, Boulier, K, Ding, Y, Johnson, R, Bhattacharya, A, Pasaniuc, B. Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles. Translational psychiatry 14(1), 2024. PMID: 38238290.
2. Chang Y, Head ST, Harrison T, Yu Y, Huff CD, Pasaniuc B, Lindström S, Bhattacharya A. Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level. medRxiv None(None):None. e-Pub 2024. PMID: 39574839.
3. Hervoso, JL, Amoah, K, Dodson, J, Choudhury, M, Bhattacharya, A, Quinones-Valdez, G, Pasaniuc, B, Xiao, X. Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia. American journal of human genetics 111(8):1573-1587, 2024. PMID: 38925119.
4. Xia, Y, Xia, C, Jiang, Y, Chen, Y, Zhou, J, Dai, R, Han, C, Mao, Z, Liu, C, Chen, C, Akbarian, S, Abyzov, A, Ahituv, N, Arasappan, D, Armenteros, JA, Beliveau, BJ, Bendl, J, Berretta, S, Bharadwaj, RA, Bhattacharya, A, Bicks, L, Brennand, KJ, Capauto, D, Champagne, FA, Chatterjee, T, Chatzinakos, C, Chen, Y, Chen, HI, Cheng, Y, Cheng, L, Chess, A, Chien, JF, Chu, Z, Clarke, D, Clement, A, Collado-Torres, L, Cooper, GM, Crawford, G, Daskalakis, NP, Davila-Velderrain, J, Deep-Soboslay, A, Deng, C, DiPietro, CP, Dracheva, S, Drusinsky, S, Duan, Z, Duong, D, Dursun, C, Eagles, NJ, Wang, H. Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders. Science translational medicine 16(749), 2024. PMID: 38781321.
5. Wen, C, Margolis, M, Dai, R, Zhang, P, Przytycki, PF, Vo, DD, Bhattacharya, A, Matoba, N, Tang, M, Jiao, C, Kim, M, Tsai, E, Hoh, C, Aygün, N, Walker, RL, Chatzinakos, C, Clarke, D, Pratt, HE, Peters, MA, Gerstein, M, Daskalakis, NP, Weng, Z, Jaffe, AE, Kleinman, JE, Hyde, TM, Weinberger, DR, Bray, NJ, Sěstan, N, Geschwind, DH, Roeder, K, Gusev, A, Pasaniuc, B, Stein, JL, Love, MI, Pollard, KS, Liu, C, Gandal, MJ. Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain. Science 384(6698), 2024. PMID: 38781368.
6. Yap, CX, Vo, DD, Heffel, MG, Bhattacharya, A, Wen, C, Yang, Y, Kemper, KE, Zeng, J, Zheng, Z, Zhu, Z, Hannon, E, Vellame, DS, Franklin, A, Caggiano, C, Wamsley, B, Geschwind, DH, Zaitlen, N, Gusev, A, Pasaniuc, B, Mill, J, Luo, C, Gandal, MJ. Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics. Science Advances 10(21), 2024. PMID: 38781333.
7. Shin, DS, Basak, S, Veena, MS, Comin-Anduix, B, Bhattacharya, A, Dong, TS, Ko, A, Han, P, Jacobs, J, Moatamed, N, Avila, L, Pellegrini, M, Wang, MB, Srivatsan, ES. Enhanced CTLA-4 blockade anti-tumor immunity with APG-157 combination in a murine head and neck cancer. Cancer medicine 13(9), 2024. PMID: 38686626.
8. Lo Faro, V, Bhattacharya, A, Zhou, W, Zhou, D, Wang, Y, Läll, K, Kanai, M, Lopera-Maya, EA, Straub, P, Pawar, P, Tao, R, Zhong, X, Namba, S, Sanna, S, Nolte, Im, Okada, Y, Ingold, N, MacGregor, S, Snieder, H, Surakka, I, Shortt, J, Gignoux, C, Rafaels, N, Crooks, K, Verma, A, Verma, SS, Guare, LA, Rader, DJ, Willer, CJ, Martin, AR, Brantley, MA, Gamazon, ER, Jansonius, NM, Joos, K, Cox, NJ, Hirbo, JB. Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation. Cell Reports Medicine 5(2), 2024. PMID: 38382466.
9. Levey, DF, Galimberti, M, Deak, JD, Wendt, FR, Bhattacharya, A, Koller, D, Harrington, KM, Quaden, R, Johnson, EC, Gupta, P, Biradar, M, Lam, M, Cooke, M, Rajagopal, VM, Empke, SL, Zhou, H, Nunez, YZ, Kranzler, HR, Edenberg, HJ, Agrawal, A, Smoller, J, Lencz, T, Hougaard, DM, Børglum, AD, Demontis, D, Gaziano, JM, Gandal, MJ, Polimanti, R, Stein, MB, Gelernter, J. Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Nature Genetics 55(12):2094-2103, 2023. PMID: 37985822.
10. Bhattacharya, A, Vo, DD, Jops, C, Kim, M, Wen, C, Hervoso, JL, Pasaniuc, B, Gandal, MJ. Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain. Nature Genetics 55(12):2117-2128, 2023. PMID: 38036788.
11. Petter, E, Ding, Y, Hou, K, Bhattacharya, A, Gusev, A, Zaitlen, N, Pasaniuc, B. Genotype error due to low-coverage sequencing induces uncertainty in polygenic scoring. American journal of human genetics 110(8):1319-1329, 2023. PMID: 37490908.
12. Mester, R, Hou, K, Ding, Y, Meeks, G, Burch, KS, Bhattacharya, A, Henn, B, Pasaniuc, B. Impact of cross-ancestry genetic architecture on GWASs in admixed populations. American journal of human genetics 110(6):927-939, 2023. PMID: 37224807.
13. Wang, X, Lu, Z, Bhattacharya, A, Pasaniuc, B, Mancuso, N. twas_sim, a Python-based tool for simulation and power analysis of transcriptome-wide association analysis. Bioinformatics 39(5), 2023. PMID: 37099718.
14. Hou, K, Ding, Y, Xu, Z, Wu, Y, Bhattacharya, A, Mester, R, Belbin, G, Buyske, S, Conti, DV, Darst, BF, Fornage, M, Gignoux, C, Guo, X, Haiman, CA, Kenny, EE, Kim, M, Kooperberg, C, Lange, L, Manichaikul, AW, North, KE, Peters, U, Rasmussen-Torvik, LJ, Rich, SS, Rotter, JI, Wheeler, HE, Wojcik, GL, Zhou, Y, Sankararaman, S, Pasaniuc, B. Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals. Nature Genetics 55(4):549-558, 2023. PMID: 36941441.
15. Johnson, R, Ding, Y, Bhattacharya, A, Knyazev, S, Chiu, A, Lajonchere, C, Geschwind, DH, Pasaniuc, B. The UCLA ATLAS Community Health Initiative. Cell Genomics 3(1), 2023. PMID: 36777178.
16. Wang, Y, Namba, S, Lopera, E, Kerminen, S, Tsuo, K, Läll, K, Kanai, M, Zhou, W, Wu, KH, Favé, MJ, Bhatta, L, Awadalla, P, Brumpton, B, Deelen, P, Hveem, K, Lo Faro, V, Mägi, R, Murakami, Y, Sanna, S, Smoller, J, Uzunovic, J, Wolford, BN, Wu, KH, Rasheed, H, Hirbo, JB, Bhattacharya, A, Zhao, H, Surakka, I, Lopera-Maya, EA, Chapman, SB, Karjalainen, J, Kurki, M, Mutaamba, M, Partanen, JJ, Chavan, S, Chen, TT, Daya, M, Ding, Y, Feng, YA, Gignoux, C, Graham, SE, Hornsby, WE, Ingold, N, Johnson, R, Laisk, T, Lin, K, Lv, J, Millwood, IY, Palta, P, Pandit, A. Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts. Cell Genomics 3(1), 2023. PMID: 36777179.
17. Kanai, M, Elzur, R, Zhou, W, Wu, KH, Rasheed, H, Tsuo, K, Hirbo, JB, Wang, Y, Bhattacharya, A, Zhao, H, Namba, S, Surakka, I, Wolford, BN, Lo Faro, V, Lopera-Maya, EA, Läll, K, Favé, MJ, Partanen, JJ, Chapman, SB, Karjalainen, J, Kurki, M, Maasha, M, Brumpton, B, Chavan, S, Chen, TT, Daya, M, Ding, Y, Feng, YA, Guare, LA, Gignoux, C, Graham, SE, Hornsby, WE, Ingold, N, Ismail, SI, Johnson, R, Laisk, T, Lin, K, Lv, J, Millwood, IY, Moreno-Grau, S, Nam, K, Palta, P, Pandit, A, Preuss, M, Saad, C, Setia-Verma, S, Thorsteinsdottir, U, Uzunovic, J, Verma, A, Zawistowski, M. Meta-analysis fine-mapping is often miscalibrated at single-variant resolution. Cell Genomics 2(12), 2022. PMID: 36643910.
18. Liu, W, Sun, Q, Huang, L, Bhattacharya, A, Wang, GW, Tan, X, Kuban, KC, Joseph, RM, O’Shea, TM, Fry, RC, Li, Y, Santos, HP. Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm. Journal of neurodevelopmental disorders 14(1), 2022. PMID: 35240980.
19. Johnson, R, Ding, Y, Venkateswaran, V, Bhattacharya, A, Boulier, K, Chiu, A, Knyazev, S, Schwarz, T, Freund, M, Zhan, L, Burch, KS, Caggiano, C, Hill, B, Rakocz, N, Balliu, B, Denny, CT, Sul, JH, Zaitlen, N, Arboleda, VA, Halperin, E, Sankararaman, S, Butte, MJ, Lajonchere, C, Geschwind, DH, Pasaniuc, B. Leveraging genomic diversity for discovery in an electronic health record linked biobank. Genome medicine 14(1), 2022. PMID: 36085083.
20. Bhattacharya, A, Freedman, AN, Avula, V, Harris, R, Liu, W, Pan, C, Lusis, AJ, Joseph, RM, Smeester, L, Hartwell, HJ, Kuban, KC, Marsit, CJ, Li, Y, O’Shea, TM, Fry, RC, Santos, HP. Placental genomics mediates genetic associations with complex health traits and disease. Nature communications 13(1), 2022. PMID: 35121757.
21. Gandal, MJ, Haney, JR, Wamsley, B, Yap, CX, Parhami, S, Emani, PS, Chang, N, Chen, GT, Hoftman, GD, de Alba, D, Ramaswami, G, Hartl, C, Bhattacharya, A, Luo, C, Jin, T, Wang, D, Kawaguchi, R, Quintero, D, Ou, J, Wu, YE, Parikshak, NN, Swarup, V, Belgard, TG, Gerstein, MB, Pasaniuc, B, Geschwind, DH. Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD. Nature 611(7936):532-539, 2022. PMID: 36323788.
22. Zhao, H, Rasheed, H, Nøst, TH, Cho, Y, Liu, Y, Bhatta, L, Bhattacharya, A, Hemani, G, Davey Smith, G, Brumpton, B, Zhou, W, Neale, BM, Gaunt, TR, Zheng, J. Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases. Cell Genomics 2(11), 2022. PMID: 36388766.
23. Tsuo K, Zhou W, Kanai M, Wang Y, Namba S, Gupta R, Majara L, Nkambule LL, Morisaki T, Okada Y, Bhattacharya A, Neale BM, Meta-analysis Initiative GB, Daly MJ, Martin AR. Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity. Cell Genomics None(None):None, 2022. PMID: 36778051.
24. Bhattacharya, A, Hirbo, JB, Zhou, D, Zhou, W, Zheng, J, Kanai, M, Pasaniuc, B, Gamazon, ER, Cox, NJ. Best practices for multi-ancestry, meta-analytic transcriptome-wide association studies. Cell Genomics 2(10), 2022. PMID: 36341024.
25. Zhou, W, Kanai, M, Wu, KH, Rasheed, H, Tsuo, K, Hirbo, JB, Wang, Y, Bhattacharya, A, Zhao, H, Namba, S, Surakka, I, Wolford, BN, Lo Faro, V, Lopera-Maya, EA, Läll, K, Favé, MJ, Partanen, JJ, Chapman, SB, Karjalainen, J, Kurki, M, Maasha, M, Brumpton, B, Chavan, S, Chen, TT, Daya, M, Ding, Y, Feng, YA, Guare, LA, Gignoux, C, Graham, SE, Hornsby, WE, Ingold, N, Ismail, SI, Johnson, R, Laisk, T, Lin, K, Lv, J, Millwood, IY, Moreno-Grau, S, Nam, K, Palta, P, Pandit, A, Preuss, M, Saad, C, Setia-Verma, S, Thorsteinsdottir, U, Uzunovic, J, Verma, A, Zawistowski, M, Zhong, X. Global Biobank Meta-analysis Initiative. Cell Genomics 2(10), 2022. PMID: 36777996.
26. Partanen JJ, Häppölä P, Zhou W, Lehisto AA, Ainola M, Sutinen E, Allen RJ, Stockwell AD, Leavy OC, Bhattacharya A, Oldham JM, Guillen-Guio B, Cox NJ, Hirbo JB, Schwartz DA, Fingerlin TE, Flores C, Noth I, Yaspan BL, Jenkins R, Wain LV, Ripatti S, Pirinen M, Genetics Consortium II, Meta-Analysis Initiative GB, Laitinen T, Kaarteenaho R, Myllärniemi M, Daly MJ, Koskela JT. Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics. Cell Genomics None(None):None, 2022. PMID: 36777997.
27. Jones, G, Hoadley, KA, Benefield, H, Olsson, LT, Hamilton, AM, Bhattacharya, A, Kirk, EL, Tipaldos, HJ, Fleming, JM, Williams, KP, Love, MI, Nichols, HB, Olshan, AF, Troester, MA. Racial differences in breast cancer outcomes by hepatocyte growth factor pathway expression. Breast Cancer Research and Treatment 192(2):447-455, 2022. PMID: 35034243.
28. Jones, G, Hoadley, KA, Olsson, LT, Hamilton, AM, Bhattacharya, A, Kirk, EL, Tipaldos, HJ, Fleming, JM, Love, MI, Nichols, HB, Olshan, AF, Troester, MA. Hepatocyte growth factor pathway expression in breast cancer by race and subtype. Breast Cancer Research 23(1), 2021. PMID: 34344422.
29. Bhattacharya, A, Hamilton, AM, Troester, MA, Love, MI. DeCompress. Nucleic acids research 49(8):E48, 2021. PMID: 33524140.
30. Bhattacharya, A, Hamilton, AM, Furberg, H, Pietzak, E, Purdue, MP, Troester, MA, Hoadley, KA, Love, MI. An approach for normalization and quality control for NanoString RNA expression data. Briefings in bioinformatics 22(3), 2021. PMID: 32789507.
31. Bhattacharya, A, Li, Y, Love, MI. MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies. PLoS genetics 17(3), 2021. PMID: 33684137.
32. Santos, HP, Adynski, H, Harris, R, Bhattacharya, A, Incollingo Rodriguez, AC, Cali, R, Yabar, AT, Nephew, BC, Murgatroyd, C. Biopsychosocial correlates of psychological distress in Latina mothers. Journal of Affective Disorders 282:617-626, 2021. PMID: 33445084.
33. Patel, A, Garcia-Closas, M, Olshan, AF, Perou, CM, Troester, MA, Love, MI, Bhattacharya, A. Gene-Level Germline Contributions to Clinical Risk of Recurrence Scores in Black and White Patients with Breast Cancer. Cancer Research 82(1):25-35, 2021. PMID: 34711612.
34. Santos Jr HP, Bhattacharya A, Joseph RM, Smeester L, K Kuban KC, Marsit CJ, O'Shea T, Fry RC. Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm. Molecular Autism None(None):None, 2020. PMID: 33308293.
35. Bhattacharya A, García-Closas M, Olshan AF, Perou CM, Troester MA, Love MI. A framework for transcriptome-wide association studies in breast cancer in diverse study populations. Genome Biology None(None):None, 2020. PMID: 32079541.
36. Santos Jr HP, Bhattacharya A, Martin EM, Addo K, Psioda M, Smeester L, Joseph RM, Hooper SR, Frazier JA, Kuban KC, O'Shea T, Fry RC. Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status. Epigenetics None(None):None, 2019. PMID: 31062658.
37. Santos Jr HP, Nephew BC, Bhattacharya A, Tan X, Smith L, S Alyamani RA, Martin EM, Perreira K, Fry RC, Murgatroyd C. Discrimination exposure and DNA methylation of stress-related genes in Latina mothers. Psychoneuroendocrinology None(None):None, 2018. PMID: 30144780.

Other Articles

1. Hou, K, Bhattacharya, A, Mester, R, Burch, KS, Pasaniuc, B On powerful GWAS in admixed populations. Nature Genetics 53(12):1631-1633, 2021. PMID: 34824480.