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      Bin Liu Image

      Bin Liu

      Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science

      Present Title & Affiliation

      Primary Appointment

      Professor, Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX

      Dual/Joint/Adjunct Appointment

      Professor, Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas

      Education & Training

      Degree-Granting Education

      2000UT Health Science Center, Houston, Texas, US, Ph.D. in Molecular Pathology and Laboratory Medicine
      1988Peking University, Beijing, CN, M.S. in Biochemistry
      1985Peking University, Beijing, CN, BS in Biochemistry

      Postgraduate Training

      2000-2003Programmer and Bioinformatics Group Leader, Bioinformatics, Baylor College of Medicine, Houston, Texas

      Experience & Service

      Faculty Academic Appointments

      Associate Professor, Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2017 - 2023

      Assistant Professor, Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2017

      Assistant Director in Center of Comparative Medicine, Baylor College of Medicine, Houston, TX, 2006 - 2010

      Assistant Professor in Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 2006 - 2010

      Bioinformatics Group Leader /Assistant Professor, Baylor College of Medicine, Houston, TX, 2002 - 2006

      Programmer and bioinformatics Group Leader, Baylor College of Medicine, Houston, TX, 2000 - 2002

      Graduate Research (Graduate study), University of Texas Health Science Center, Houston, TX, 1994 - 2000

      Extramural Institutional Committee Activities

      Member, MDA High Performance Computation Committee, The University of Texas MD Anderson Cancer Center, 2013 - Present

      Honors & Awards

      2008Director Award, CCM, Baylor College of Medicine

      Professional Memberships

      American Society of Human Genetics

      2019

      American Association for the Advancement of Science

      2017 - Present

      International Society for Biocuration

      2015 - 2016

      International Society for Computational Biology

      2011 - 2024

      Selected Presentations & Talks

      Formal Peers

      1. 2016. Tumor Heterogeneity. Invited. Fuzhou, FuJian, CN.
      2. 2013. Mutational Heterogeneity in Adenoid Cystic Carcinoma. Invited. Houston, TX, US.
      3. 2013. Mapping The Spatial And Temporal Heterogeneity In Adenoid Cystic Carcinoma. Invited. Houston, TX, US.
      Read More
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      Selected Publications

      Peer-Reviewed Articles

      1. Liu B, Xiong S, Williams-Villalobo A, Chau G, Qi Y, Chen H, Johnson C, Chachad D, McDaniel J, Su X, El-Naggar AK, Lozano G, Zhang Y. Stromal fibroblastic mutant Trp53 promotes mammary tumor development via enhanced secretion of paracrine factors. NPJ Breast Cancer 12(1):12, 2025. e-Pub 2025. PMID: 41387465.
      2. Hussain T, Bramble MD, Liu B, Abba MC, Chesi M, Aldaz CM. B-cell-specific Wwox deletion promotes plasmablastic tumor development and proinflammatory signatures in myeloma model. Blood Neoplasia 2(4):100153, 2025. e-Pub 2025. PMID: 41090157.
      3. Li, Y, Dang, N, He, W, Returan, M, Carvajal-Maldonado, D, Guerin, AT, Xu, H, Liu, B, Wood, R. Pol θ-mediated end-joining uses microhomologies containing mismatches. Nature communications 16(1), 2025. e-Pub 2025. PMID: 40603872.
      4. Kircher, BK, Liu, B, Bramble, M, Moses, MM, Behringer, RR. Gene expression profile analysis of subregions of the adult female reproductive tract in the brown anole, Anolis sagrei. Reproduction 169(2), 2025. e-Pub 2025. PMID: 39561037.
      5. Zhang, Y, Simko, AC, Okoro, U, Sibert, DJ, Moon, JH, Liu, B, Matin, A. Commitment Complex Splicing Factors in Cancers of the Gastrointestinal Tract—An In Silico Study. Bioinformatics and Biology Insights 18, 2024. e-Pub 2024. PMID: 39421280.
      6. Hardikar S, Ren R, Ying Z, Zhou J, Horton JR, Bramble MD, Liu B, Lu Y, Liu B, Coletta LD, Shen J, Dan J, Zhang X, Cheng X, Chen T. The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA. Science Advances 10(34):eadr0036, 2024. e-Pub 2024. PMID: 39178265.
      7. Wang, Y, Zhou, J, He, W, Fu, R, Shi, L, Dang, NK, Liu, B, Xu, H, Cheng, X, Bedford, MT. SART3 reads methylarginine-marked glycine- and arginine-rich motifs. Cell Reports 43(7), 2024. e-Pub 2024. PMID: 38985674.
      8. Malone, CF, Mabe, NW, Forman, AB, Alexe, G, Engel, KL, Chen, YJ, Soeung, M, Salhotra, S, Basanthakumar, A, Liu, B, Dent, SR, Stegmaier, K. The KAT module of the SAGA complex maintains the oncogenic gene expression program in MYCN-amplified neuroblastoma. Science Advances 10(22), 2024. e-Pub 2024. PMID: 38820154.
      9. Pourebrahim, R, Montoya, RH, Akiyama, H, Ostermann, LB, Khazaei, S, Muftuoglu, M, Baran, N, Zhao, R, Lesluyes, T, Liu, B, Khoury, J, Gagea Iurascu, M, Van Loo, P, Andreeff, M. Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice. Cell Reports Medicine 5(5), 2024. e-Pub 2024. PMID: 38733986.
      10. Hogan, CH, Owens, SM, Reynoso, GV, Liao, Y, Meyer, TJ, Zelazowska, M, Liu, B, Li, X, Grosskopf, AK, Khairallah, C, Kirillov, V, Reich, NC, Sheridan, BS, McBride, K, Gewurz, BE, Hickman-Miller, H, Forrest, JC, Krug, LT. Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. mBio 15(2), 2024. e-Pub 2024. PMID: 38170993.
      11. Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T. Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24. Cell Mol Immunol 12:1487-1498, 2023. e-Pub 2023. PMID: 37990035.
      12. Wright, T, Wang, Y, Stratton, SA, Sebastian, MM, Liu, B, Johnson, DG, Bedford, MT. Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma. Biochemical Journal 480(22):1805-1816, 2023. e-Pub 2023. PMID: 37905668.
      13. Yang J, Horton JR, Liu B, Corces VG, Blumenthal RM, Zhang X, Cheng X. Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res 51(16):8447-8462, 2023. e-Pub 2023. PMID: 37439339.
      14. Saha D, Hailu S, Hada A, Lee J, Luo J, Ranish JA, Lin YC, Feola K, Persinger J, Jain A, Liu B, Lu Y, Sen P, Bartholomew B. The AT-hook is an evolutionarily conserved auto-regulatory domain of SWI/SNF required for cell lineage priming. Nat Commun 14(1):4682, 2023. e-Pub 2023. PMID: 37542049.
      15. Pourebrahim R, Heinz Montoya R, Alaniz Z, Ostermann L, Lin PP, Liu B, Ayoub E, Burks JK, Andreeff M. Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage. Cell Death Dis 14(6):371, 2023. e-Pub 2023. PMID: 37353528.
      16. Fan Y, Li Y, Yao X, Jin J, Scott A, Liu B, Wang S, Huo L, Wang Y, Wang R, Pool Pizzi M, Ma L, Shao S, Sewastjanow-Silva M, Waters R, Chatterjee D, Liu B, Shanbhag N, Peng G, Calin GA, Mazur PK, Hanash SM, Ishizawa J, Hirata Y, Nagano O, Wang Z, Wang L, Xian W, McKeon F, Ajani JA, Song S. Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment. Gut 72(4):624-637, 2023. e-Pub 2023. PMID: 36002248.
      17. Zhang Y, Williams-Villalobo A, Godavarthi JD, Shakoor F, Xiong S, Liu B. Integrative bioinformatic analysis of p53 and pathway alterations in two different lung cancer subtypes. Biochem Biophys Rep 33:101404, 2023. e-Pub 2023. PMID: 36532876.
      18. Ren R, Horton JR, Chen Q, Yang J, Liu B, Huang Y, Blumenthal RM, Zhang X, Cheng X. Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J Biol Chem 299(2):102885, 2023. e-Pub 2023. PMID: 36626981.
      19. Gao G, Hausmann S, Flores NM, Benitez AM, Shen J, Yang X, Person MD, Gayatri S, Cheng D, Lu Y, Liu B, Mazur PK, Bedford MT. The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer. Nat Commun 14(1):363, 2023. e-Pub 2023. PMID: 36690626.
      20. Zhang Y, Li Y, Chachad D, Liu B, Godavarthi JD, Williams-Villalobo A, Lasisi L, Xiong S, Matin A. In silico analysis of DND1 and its co-expressed genes in human cancers. Biochem Biophys Rep 29(29):101206, 2022. e-Pub 2022. PMID: 35059511.
      21. Song S, Chen Q, Li Y, Lei G, Scott A, Huo L, Li CY, Estrella JS, Correa A, Pizzi MP, Ma L, Jin J, Liu B, Wang Y, Xiao L, Hofstetter WL, Lee JH, Weston B, Bhutani M, Shanbhag N, Johnson RL, Gan B, Wei S, Ajani JA. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. Gut 70(12):2238-2248, 2021. e-Pub 2021. PMID: 33487592.
      22. Yang F, Chen J, Liu B, Gao G, Sebastian M, Jeter C, Shen J, Person MD, Bedford MT. SPINDOC binds PARP1 to facilitate PARylation. Nat Commun 12(1):6362, 2021. e-Pub 2021. PMID: 34737271.
      23. Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC. Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun 12(1):5389, 2021. e-Pub 2021. PMID: 34508101.
      24. Kim MP, Li X, Deng J, Zhang Y, Dai B, Allton KL, Hughes TG, Siangco C, Augustine JJ, Kang Y, McDaniel JM, Xiong S, Koay EJ, McAllister F, Bristow CA, Heffernan TP, Maitra A, Liu B, Barton MC, Wasylishen AR, Fleming JB, Lozano G. Oncogenic KRAS recruits an expansive transcriptional network through mutant p53 to drive pancreatic cancer metastasis. Cancer Discov 11(8):2094-2111, 2021. e-Pub 2021. PMID: 33839689.
      25. Chen LM, Chai JC, Liu B, Strutt TM, McKinstry KK, Chai KX. Prostasin regulates PD-L1 expression in human lung cancer cells. Biosci Rep 41(7), 2021. e-Pub 2021. PMID: 34240739.
      26. Karpinets TV, Mitani Y, Liu B, Zhang J, Pytynia KB, Sellen LD, Karagiannis DT, Ferrarotto R, Futreal AP, El-Naggar AK. Whole-Genome Sequencing of Common Salivary Gland Carcinomas: Subtype-Restricted and Shared Genetic Alterations. Clin Cancer Res 27(14):3960-3969, 2021. e-Pub 2021. PMID: 34011559.
      27. Yan L, Gaddis S, Coletta LD, Repass J, Powell KL, Simper MS, Chen Y, Byrom M, Zhong Y, Lin K, Liu B, Lu Y, Shen J, MacLeod MC. ATF3-Induced Mammary Tumors Exhibit Molecular Features of Human Basal-Like Breast Cancer. Int J Mol Sci 22(5):1-18, 2021. e-Pub 2021. PMID: 33652981.
      28. Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK. Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets. Clin Cancer Res 27(3):852-864, 2021. e-Pub 2021. PMID: 33172898.
      29. Kumar A, Zhong Y, Albrecht A, Sang PB, Maples A, Liu Z, Vinayachandran V, Reja R, Lee CF, Kumar A, Chen J, Xiao J, Park B, Shen J, Liu B, Person MD, Trybus KM, Zhang KYJ, Pugh BF, Kamm KE, Milewicz DM, Shen X, Kapoor P. Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription. Cell Rep 32(13):108172, 2020. e-Pub 2020. PMID: 32997990.
      30. Zelazowska MA, Dong Q, Plummer JB, Zhong Y, Liu B, Krug LT, McBride KM. Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire. Life Sci Alliance 3(3), 2020. e-Pub 2020. PMID: 32029571.
      31. Song S, Wang Z, Li Y, Ma L, Jin J, Scott AW, Xu Y, Estrella JS, Song Y, Liu B, Johnson RL, Ajani JA. PPARδ Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression. Mol Cancer Res 18(3):390-402, 2020. e-Pub 2020. PMID: 31796534.
      32. Manickavinayaham S, Vélez-Cruz R, Biswas AK, Bedford E, Klein BJ, Kutateladze TG, Liu B, Bedford MT, Johnson DG. E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. Nat Commun 10(1):4951, 2019. e-Pub 2019. PMID: 31666529.
      33. Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K. Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer. Clin Cancer Res 25(13):3996-4013, 2019. e-Pub 2019. PMID: 30867218.
      34. Marisetty AL, Lu L, Veo BL, Liu B, Coarfa C, Kamal MM, Kassem DH, Irshad K, Lu Y, Gumin J, Henry V, Paulucci-Holthauzen A, Rao G, Baladandayuthapani V, Lang FF, Fuller GN, Majumder S. REST-DRD2 mechanism impacts glioblastoma stem cell-mediated tumorigenesis. Neuro Oncol 21(6):775-785, 2019. e-Pub 2019. PMID: 30953587.
      35. Aryal NK, Pant V, Wasylishen AR, Parker-Thornburg J, Baseler L, El-Naggar AK, Liu B, Kalia A, Lozano G, Arur S. Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci U S A 116(3):960-969, 2019. e-Pub 2019. PMID: 30593561.
      36. Zhang Y, Xiong S, Liu B, Pant V, Celii F, Chau G, Elizondo-Fraire AC, Yang P, You MJ, El-Naggar AK, Navin NE, Lozano G. Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. Nat Commun 9(1):3953, 2018. e-Pub 2018. PMID: 30262850.
      37. Mullen RD, Wang Y, Liu B, Moore EL, Behringer RR. Osterix functions downstream of anti-Müllerian hormone signaling to regulate Müllerian duct regression. Proc Natl Acad Sci U S A 115(33):8382-8387, 2018. e-Pub 2018. PMID: 30061417.
      38. Lu L, Marisetty A, Liu B, Kamal MM, Gumin J, Veo B, Cai Y, Kassem DH, Weng C, Maynard ME, Hood KN, Fuller GN, Pan ZZ, Cykowski MD, Dash PK, Majumder S. REST overexpression in mice causes deficits in spontaneous locomotion. Sci Rep 8(1):12083, 2018. e-Pub 2018. PMID: 30108242.
      39. Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, Lin SH. Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway. Cancer Res 78(11):2911-2924, 2018. e-Pub 2018. PMID: 29514796.
      40. Larsson CA, Moyer SM, Liu B, Michel KA, Pant V, Yang P, Wong J, El-Naggar AK, Krahe R, Lozano G. Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration. Proc Natl Acad Sci U S A 115(9):2198-2203, 2018. e-Pub 2018. PMID: 29440484.
      41. Ajani JA, Estrella JS, Chen Q, Correa AM, Ma L, Scott AW, Jin J, Liu B, Xie M, Sudo K, Shiozaki H, Badgwell B, Weston B, Lee JH, Bhutani MS, Onodera H, Suzuki K, Suzuki A, Ding S, Hofstetter WL, Johnson RL, Bresalier RS, Song S. Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors. Br J Cancer 118(1):52-61, 2018. e-Pub 2018. PMID: 29136404.
      42. Yuan T, Yang Y, Chen J, Li W, Li W, Zhang Q, Mi Y, Goswami RS, You JQ, Lin D, Qian MD, Calin S, Liang Y, Miranda RN, Calin GA, Zhou X, Ma L, Zweidler-McKay PA, Liu B, Weng AP, Medeiros LJ, Zhang Y, You MJ. Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD. Leukemia 31(11):2355-2364, 2017. e-Pub 2017. PMID: 28280276.
      43. Liu B, Mitani Y, Rao X, Zafereo M, Zhang J, Zhang J, Futreal PA, Lozano G, El-Naggar AK. Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma. J Natl Cancer Inst 109(10), 2017. e-Pub 2017. PMID: 29117356.
      44. Pourebrahim R, Zhang Y, Liu B, Gao R, Xiong S, Lin PP, McArthur MJ, Ostrowski MC, Lozano G. Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein. Genes Dev 31(18):1847-1857, 2017. e-Pub 2017. PMID: 29021240.
      45. Wadhwa R, Wang X, Baladandayuthapani V, Liu B, Shiozaki H, Shimodaira Y, Lin Q, Elimova E, Hofstetter WL, Swisher SG, Rice DC, Maru DM, Kalhor N, Bhutani MS, Weston B, Lee JH, Skinner HD, Scott AW, Kaya DM, Harada K, Berry D, Song S, Ajani JA. Nuclear expression of Gli-1 is predictive of pathologic complete response to chemoradiation in trimodality treated oesophageal cancer patients. Br J Cancer 117(5):648-655, 2017. e-Pub 2017. PMID: 28728163.
      46. Li J, Mitani Y, Rao PH, Perlaky L, Liu B, Weber RS, El-Naggar AK. Establishment and genomic characterization of primary salivary duct carcinoma cell line. Oral Oncol 69:108-114, 2017. e-Pub 2017. PMID: 28559013.
      47. Marisetty AL, Singh SK, Nguyen TN, Coarfa C, Liu B, Majumder S. REST represses miR-124 and miR-203 to regulate distinct oncogenic properties of glioblastoma stem cells. Neuro Oncol 19(4):514-523, 2017. e-Pub 2017. PMID: 28040710.
      48. McCallum KC, Liu B, Fierro-González JC, Swoboda P, Arur S, Miranda-Vizuete A, Garsin DA. TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans. Genetics 203(1):387-402, 2016. e-Pub 2016. PMID: 26920757.
      49. Mitani Y, Liu B, Rao PH, Borra VJ, Zafereo M, Weber RS, Kies M, Lozano G, Futreal PA, Caulin C, El-Naggar AK. Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clin Cancer Res 22(3):725-33, 2016. e-Pub 2016. PMID: 26631609.
      50. Lee YC, Lin SC, Yu G, Cheng CJ, Liu B, Liu HC, Hawke DH, Parikh NU, Varkaris A, Corn P, Logothetis C, Satcher RL, Yu-Lee LY, Gallick GE, Lin SH. Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer. Cancer Res 75(22):4949-59, 2015. e-Pub 2015. PMID: 26530902.
      51. P* S, PO* Z, AL* M, B* L, MM* K, Singh SK, Bady P, Lu L, Wani KM, Veo BL, Gumin J, Kassem DH, Robinson F, Weng C, Baladandayuthapani V, Suki D, Colman H, Bhat KP, Sulman EP, Aldape K, Colen RR, Verhaak RG, Lu Z, Fuller GN, Huang S, Lang FF, Sawaya R, Hegi M, Majumder S. Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact. J Neurosci 35(45):15097-112, 2015. e-Pub 2015. PMID: 26558781.
      52. Li Y, Xiao X, Ji X, Liu B, Amos CI. RNA-seq analysis of lung adenocarcinomas reveals different gene expression profiles between smoking and nonsmoking patients. Tumour Biol 36(11):8993-9003, 2015. e-Pub 2015. PMID: 26081616.
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      Review Articles

      1. Hussain T, Liu B, Shrock MS, Williams T, Aldaz CM. WWOX, the FRA16D gene: A target of and a contributor to genomic instability. Genes Chromosomes Cancer 58(5):324-338, 2019. e-Pub 2019. PMID: 30350478.
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