Bin Wang, Ph.D.
Department of Genetics, Division of Discovery Science
About Dr. Bin Wang
Dr. Wang is a Professor in the Department of Genetics. Her research is focused on understanding how cells respond to DNA damage and safeguard the integrity of the genome. Her laboratory takes multidisciplinary approach to identify important players in the DNA damage response and define the roles of these genes in maintaining genomic stability and tumor suppression.
View a compelte list of Dr. Wang's publications.
Visit Dr. Wang's Lab website.
Present Title & Affiliation
Primary Appointment
Professor, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX
Professor, Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX
Professor, Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
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A hallmark of cancer is genomic instability. Defects in the ability of cells to properly respond to and repair DNA damage result in genomic instability and underlie many forms of cancer. The goal of our research is to understand how cells respond to DNA damage and safeguard the integrity of the genome. We use functional and molecular approaches that involve imaging, CRISPR/Cas9 gene editing, genetics screens, high throughput sequencing, mass spectrometry, mouse model, etc.
Ongoing Projects:
(1) How does the hereditary breast tumor suppressor BRCA1 interaction network suppress breast tumor development? (Castillo et al, Cell Rep 8, 807-817, 2014; Wu et al, Mol Cell 61, 434-448, 2016);
(2) How does chromatin modification at sites of DNA damage regulate DNA repair and transcription? (Paul and Wang, Mol Cell 66, 458-472, 2017; Wu et al, Genes Dev 33, 1702-1717, 2019);
(3) How does the cell protect genome stability in response to DNA replication stress? (Xu et al, Genes Dev 31, 1469-1482, 2017)
https://mdanderson.elsevierpure.com/en/persons/bin-wang
Visit Dr. Wang's lab website.
View a complete list of Dr. Wang's publications.
Education & Training
Degree-Granting Education
| 2000 | Baylor College of Medicine, Houston, Texas, US, Biochemistry and Molecular Biology, Ph.D |
| 1994 | Shanghai Institute of Biochemistry, Shanghai, CN, Molecular Biology, M.S |
| 1991 | Nanjing University, Nanjing, CN, Biochemistry, BS |
Postgraduate Training
| 2003-2008 | Postdoctoral Fellow, Harvard Medical School / Brigham and Women's Hospital, Boston, MA |
| 2000-2003 | Postdoctoral Fellow, Baylor College of Medicine, Houston, Texas |
Experience & Service
Faculty Academic Appointments
Associate Professor, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, 2014 - 2022
Associate Professor, Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2022
Assistant Professor, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, 2008 - 2014
Assistant Professor, Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2014
Other Professional Positions
Co-Director, GSBS Genetics & Epigenetics PHD Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedicas Sciences, 2026 - 2028
Honors & Awards
| 2023 - 2025 | Faculty Senate, MD Anderson Cancer Center |
| 2022 | Provost's Wall of Science, MD Anderson Cancer Center |
| 2016 | GSBS Faculty Recognition Award, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences |
| 2016 | Provost's Wall of Science, MD Anderson Cancer Center |
| 2009 - 2011 | Sidney Kimmel Scholar, Sidney Kimmel Foundation for Cancer Research |
| 2005 - 2010 | Howard Temin Award, National Institute of Health, National Cancer Institute |
| 2002 - 2005 | Postdoctoral Fellowship, US Army Breast Cancer Foundation |
| 1999 | Annual Graduate Student Symposium platform presentation speaker, Baylor College of Medicine Graduate School of Biomedical Sciences |
Selected Publications
Peer-Reviewed Articles
- Wang, L, Wu, X, Paul, A, Yao, J, Wang, B. The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2Sdependent Lys11-linked ubiquitination. PLoS biology 23(12), 2025. e-Pub 2025. PMID: 41359628.
- Ye, Z, Xu, S, Shi, Y, Cheng, X, Zhang, Y, Roy, S, Namjoshi, S, Longo, M, Link, T, Schlacher, K, Peng, G, Yu, D, Wang, B, Tainer, J, Ahmed, Z. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nature Commun 15(1):2132, 2024. e-Pub 2024. PMID: 38459011.
- Liu S, Atkinson E, Paulucci-Holthauzen A, Wang B. A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G quadruplex resolution. Nature Commun 14(1):6111, 2023. e-Pub 2023. PMID: 37777511.
- Shao, N, Zhou, Y, Yao, J, Zhang, P, Song, Y, Zhang, K, Han, X, Wang, B, Liu, X. A Bidirectional Single-Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration. Advanced Science 10(8), 2023. e-Pub 2023. PMID: 36658690.
- Emam A, Wu X, Xu S, Wang L, Liu S, Wang B. Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signalling. Nat Cell Biol 24(7):1154-1164, 2022. e-Pub 2022. PMID: 35817959.
- Zu Y, Xu S, Shi Y, Bacolla A, Syed A, Moiani, D, Shen C, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv 7(32):eabe9254, 2021. e-Pub 2021. PMID: 34348893.
- Wu X, Wang B. Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage. Nat Commun 12(1):4373, 2021. e-Pub 2021. PMID: 34272385.
- Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y. Alteration of DNA Damage Response Causes Cleft Palate. Front Physiol 12:649492, 2021. e-Pub 2021. PMID: 33854442.
- Zhang P, Yao J, Wang B, Qin L. Microfluidics-Based Single-Cell Protrusion Analysis for Screening Drugs Targeting Subcellular Mitochondrial Trafficking in Cancer Progression. Anal Chem 92(4):3095-3102, 2020. e-Pub 2020. PMID: 31965790.
- Chu YY, Yam C, Chen MK, Chan LC, Xiao M, Wei YK, Yamaguchi H, Lee PC, Han Y, Nie L, Sun X, Moulder SL, Hess KR, Wang B, Hsu JL, Hortobagyi GN, Litton J, Chang JT, Hung MC. Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. Am J Cancer Res 10(2):648-661, 2020. e-Pub 2020. PMID: 32195033.
- Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturevedi A, Horton JR, Cheng X, Bedford MT, Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. *Co-corresponding author. Genes Dev 33:1702-1717, 2019. e-Pub 2019. PMID: 31699778.
- Zhang P, Han X, Yao J, Shao N, Zhang K, Zhou Y, Zu Y, Wang B, Qin L. High-Throughput Isolation of Cell Protrusions with Single-Cell Precision for Profiling Subcellular Gene Expression. *Co-corresponding authors. Angew Chem, 2019. e-Pub 2019. PMID: 31188523.
- Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y. BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLOS Genetics 14(5):1007340, 2018. e-Pub 2018.
- Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, S-C S, and Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci USA 115(10):2311-2319, 2018. e-Pub 2018.
- Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev 31(14):1469-1482, 2017. e-Pub 2017. PMID: 28860160.
- Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell 66(4):458-472, 2017. e-Pub 2017. PMID: 28525740.
- Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blunder TL. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. *Co-corresponding authors. Mol Cell 61(3):434-48, 2016. e-Pub 2016. PMID: 26778126.
- Ling H, Hu X, Li S, Qiao F, Yao L, Cao Z, Li K, Ye F, Wang B, Shao Z. Evaluation of BRCA1 associated A complex with triple negative breast cancer susceptibility in Chinese women. *Co-corresponding authors. Oncotarget 7(9):9759-72, 2016. e-Pub 2016.
- Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B. The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression. Cell Rep 8(3):807-17, 2014. e-Pub 2014. PMID: 25066119.
- Desai S, Ding M, Wang B, Lu Z, Zhao Q, Shaw K, Yung WKA, Weinstein, Tan M, Yao J. Tissue-specific isoform switch and DNA hypomethylation of the PKM2 gene in human cancer. Oncotarget 5(18):8202-10, 2013. e-Pub 2013.
- Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, Zhang D. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A 110(33):13558-63, 2013. e-Pub 2013. PMID: 23901102.
- Hu X, Paul A, Wang B. Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates. J Biol Chem 287(30):25510-9, 2012. e-Pub 2012. PMID: 22689573.
- Hu X, Kim JA, Castillo A, Huang M, Liu J, Wang B. NBA1/Merit40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 containing complexes. J Biol Chem 286(13):11734-45, 2011. e-Pub 2011. PMID: 21282113.
- Wang B, Hurov K, Hofmann K, Elledge SJ. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev 23(6):729-39, 2009. e-Pub 2009. PMID: 19261749.
- Xiao A, Li H, Schecter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 457(7225):57-62, 2009. e-Pub 2009. PMID: 19092802.
Invited Articles
- Wang B. BRCA1 Tumor Suppressor Network: Focusing on Its Tail. Cell & Bioscience 2:6, 2012. e-Pub 2012.
Book Chapters
- Wang B. Assaying cell cycle checkpoints in mammalian cells. In: Cell Cycle Control: Mechanisms and Protocols. Second Edition. Human Press/Springer, 2014.
Patient Reviews
CV information above last modified September 11, 2026