Meet Bora Lim, M.D.
Bora Lim, M.D.
Department of Breast Medical Oncology, Division of Cancer Medicine
About Dr. Bora Lim
Bora Lim is an esteemed associate professor at The University of Texas MD Anderson Cancer Center, at the forefront of translational research in oncology. As the Chief of the Translational Research section, Dr. Lim is not just a researcher; she's a visionary, crafting innovative therapeutic strategies to confront and conquer aggressive breast cancers. Her unique approach leverages precise tissue analysis and rigorous bench validation to ensure the highest efficacy in clinical applications.
At the helm of the OPTIMA program, Dr. Lim orchestrates a symphony of collaboration among internal and external investigators. Her mission: to unearth new therapeutic vulnerabilities and decipher the resistance mechanisms of rare and formidable breast cancers. Trust in Dr. Lim's expertise to illuminate the path toward new life-saving treatments in the fight against breast cancer.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Breast Medical Oncology, Division of Cancer Medicine, UT MD Anderson Cancer Center, Houston, TX
Chief, Section of Translational Breast Cancer Research, Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston
Director, Translational Research, Department of The Morgan Welch IBC Research Program and Clinic, Division of Cancer Medicine, UT MD Anderson Cancer Center, Houston, TX
Research Interests
As a dedicated researcher, my passion lies in pioneering investigator-initiated trials that blend innovative scientific reasoning with robust prognostic and predictive biomarkers, particularly for cancers that challenge current medical practices. I proudly lead as a principal investigator for ground-breaking phase Ib/II trials. My purpose is clear: to alleviate the pain and distress faced by patients enduring aggressive breast cancers, including triple-negative and inflammatory breast cancers. Through the design of cutting-edge translational trials and the execution of scientifically rigorous pre-clinical studies, my goal is to open new horizons in treatment possibilities and improve patient outcomes.
Education & Training
Degree-Granting Education
2004 | Ewha Womans University, School of Medicine, Seoul, KOR, MD, Medicine |
Postgraduate Training
2017-2017 | Integrated Translational Science Center, South Western Oncology Group, Cold Spring Harbor |
2015-2015 | Research Fellowship, IDB, CTEP, National Cancer Institute, Bethesda, MD |
2015-2016 | Heart of Leadership, The University of Texas MD Anderson Cancer Center, Houston, TX |
2015-2015 | The AAMC Early Career Women Faculty Professional Development Seminar, American Association of Medical Colleges, Englewood, CO |
2015-2015 | Clinical Trial Workshop, The University of Texas MD Anderson Cancer Center, Houston, TX |
2014-2015 | Faculty Supervisory & Management Program, The University of Texas MD Anderson Cancer Center, Houston, TX |
2014-2014 | Molecular biology, Molecular Biology, American Association for Cancer Research, Aspen, CO |
2013-2013 | Clinical Trial, Methods in Cancer, Clinical Trial, Methods in Cancer, American Association for Cancer Research, American Society of Clinical Oncology, Vail, CO |
2012-2014 | Research Fellowship, Experimental therapeutics, Penn State Hershey Cancer Institute, El-Deiry Laboratory of Experimental Therapeutics, Hershey, PA |
2011-2014 | Clinical Fellowship, Hematology-Oncology, Penn State Hershey Medical Center, Penn State College of Medicine, Hershey, PA |
2010-2011 | Chief Medical Residency, Internal Medicine, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA |
2007-2010 | Clinical Residency, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA |
2004-2005 | Clinical Internship, Surgery, Catholic Medical Center, Seoul |
Board Certifications
2014 | American Board of Internal Medicine, Specialty in Hematology |
2014 | American Board of Internal Medicine, Specialty in Oncology |
2006 | Educational Commission for Foreign Medical Graduates |
Experience & Service
Academic Appointments
Associate Professor, Division of Dan L. Duncan Comprehensive Cancer Center, (Tenured), Breast Oncology, Department of Hematology/Oncology, Houston, TX, 2020 - 2023
Assistant Professor, Department of Breast Medical Oncology, Section of the Translational Breast Cancer Research, Morgan Welch Inflammatory Breast Cancer Research Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2020
Professional Staff, Department of Medicine, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA, 2010 - 2011
Administrative Appointments/Responsibilities
Director, Translational Research, Baylor College of Medicine, Houston, TX, 2020 - 2023
Associate Director for Clinical Science, The Lester and Sue Smith Breast Center Laboratories, Houston, TX, 2020 - 2023
Joint Appointmet, Clinical Research Group-Translational Molecular Pathology (CRG-TMP) Group Lead, Department of Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX, 2020 - 2020
Clinical Research Director, Department of Morgan Welch IBC Research and Clinic Program, Morgan Welch Inflammatory Breast Cancer Research and Clinic Program, Houston, TX, 2018 - 2020
Other Appointments/Responsibilities
Clinical Lead/co-investigator, CPRIT proteogenomics, Houston, TX, 2022 - Present
CME Committee Member, American Association for Cancer Research, Philadelphia, PA, 2019 - Present
Medical Advisory Council Member, Susan G. Komen Houston, Houston, TX, 2019 - Present
ASCO University Educational Review/Question Generation Committee Member, American Society of Clinical Oncology, Alexandria, VA, 2019 - 2020
Breast Cancer Working Group Committee, Translational Working Group Committee, South Western Oncology Group, San Francisco, CA, 2017 - Present
Chief Family Physician, Jeju-Jaeil Family Clinic, Jeju, 2006 - 2007
Nocturnal Chief Physician, Bucheon Burn/Emergency Center, Bucheon, 2006 - 2006
General Volunteer Practitioner, Yong-san121st General Hospital, Seoul, 2006 - 2007
Supervised Physician, JM Dermatology Clinic, Seoul, 2006 - 2006
General Practitioner, Yeonsoo Central Hospital, Incheon, 2005 - 2006
Counseling Managing Physician, Korea Health Promotion Association, Incheon, 2005 - 2006
President of Student Body, Ewha Womans University School of Medicine Student Body, Seoul, 2001 - 2002
Institutional Committee Activities
Breast Lead, U54 Disparity Grant, 2022 - Present
Member, Disease Review Committee, 2021 - Present
Chair, Clinical Trial Working Group, IBC-IC, 2020 - Present
Member, Locoregional Working Group Committee, TBCRC, 2020 - Present
Member, Translatinal Working Group Committee, SWOG, Medical Advisory Council Member, Susan G. Komen Houston, 2020 - Present
ASCO Representative, ASCO-CAP Cancer Committee, 2020 - Present
Administrative Core and Project 1 Clinical Lead, Breast Spore, 2020 - Present
Member, Scientific Review Committee #3, 2020 - 2020
Program Organizer, The Biology of Apoptosis, 2019 - Present
Chair, TMP-CRG (Translational Molecular Pathology-Clinical Research Group), 2019 - 2020
Member, Immunotherapy Working Gruop Committee, 2019 - 2020
Member, Breast Medical Oncology Representative, Junior Faculty Committee, 2018 - Present
Steering Committee Faculty Member, Advanced Breast Cancer Clinic, 2016 - 2020
Member and Secretariat, Triple Negative working Group Committee, 2015 - 2020
Member and Secretariat, Inflammatory Breast Cancer Working Group Committee, 2015 - 2020
Leader of Breast Group, Junior Faculty Committee, 2015 - 2020
Member, Triple Negative Breast Cancer Working Group, 2015 - Present
Member, Inflammatory Breast Cancer Working Group, 2015 - Present
Director, Grand Rounds for Pennsylvania Hospital/Philadelphia Internal Medicine Community Pennsylvania Hospital, University of Pennsylvania Health System, 2010 - 2011
Member, House Staff Representative, Route Cause Analysis/Blood Stream Infection Committee, Pennsylvania Hospital, University of Pennsylvania Health System, 2010 - 2011
Member, ED Efficiency Improvement Committee, Pennsylvania Hospital, University of Pennsylvania Health System, 2010 - 2011
Member, Health Literacy Committee, Pennsylvania Hospital, University of Pennsylvania Health System, 2010 - 2011
Member, Patient Drug and Safety Committee, 2010 - 2011
Honors & Awards
2023 | Excellence in Clinical Research, Theresa Research Foundation |
2022 | Patient Experience, All Stars, 2022 |
2022 | Breast Cancer Care and Research Honoree, For the Breast of Us |
2020 | Woman of the Week, Diverse Health Hub |
2020 | Multidisciplinary Breast Program Outstanding Teacher Award, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center |
2017 | South Western Oncology Group Translational Workshop, Hope Foundation, South Western Oncology Group Translational Workshop |
2017 | Multidisciplinary Breast Program Outstanding Teacher Award, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center |
2017 | CTEP young investigator CDA (Career Development Award), National Cancer Institute |
2015 | Clinical Trials Methods & Design Workshop for MDACC Junior Faculty, The University of Texas MD Anderson Cancer Center |
2015 | AAMC-Early-Career Women Faculty Professional Development Program, Women Faculty Program, The University of Texas MD Anderson Cancer Center, Americal Association for Medical Colleges |
2014 | AACR Aspen Workshop, Molecular Biology in Clinical Oncology, AACR |
2014 | Best Fellow Research Award, Penn State Hershey Medical Center, Penn State College of Medicine |
2013 | AACR/ASCO Vail workshop, Methods in Clinical Cancer Research, AACR/ASCO |
2011 | Lou-Dinon Teaching Award, University of Pennsylvania Medical Students, Pennsylvania Hospital, University of Pennsylvania |
2006 | Certificate of Appreciation, 121st General Hospital, 18th Medical Command |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Kalra R, Lim B, Ellis MJ, Kavuri SM. The uncharted role of HER2 mutant alleles in breast cancer. Oncotarget 14:904-907, 2023. e-Pub 2023. PMID: 37921670.
- Kumar T, Nee K, Wei R, He S, Nguyen QH, Bai S, Blake K, Pein M, Gong Y, Sei E, Hu M, Casasent AK, Thennavan A, Li J, Tran T, Chen K, Nilges B, Kashikar N, Braubach O, Ben Cheikh B, Nikulina N, Chen H, Teshome M, Menegaz B, Javaid H, Nagi C, Montalvan J, Lev T, Mallya S, Tifrea DF, Edwards R, Lin E, Parajuli R, Hanson S, Winocour S, Thompson A, Lim B, Lawson DA, Kessenbrock K, Navin N. A spatially resolved single-cell genomic atlas of the adult human breast. Nature 620(7972):181-191, 2023. e-Pub 2023. PMID: 37380767.
- Zhang Y, Zhao Z, Huang LA, Liu Y, Yao J, Sun C, Li Y, Zhang Z, Ye Y, Yuan F, Nguyen TK, Garlapati NR, Wu A, Egranov SD, Caudle AS, Sahin AA, Lim B, Beretta L, Calin GA, Yu D, Hung MC, Curran MA, Rezvani K, Gan B, Tan Z, Han L, Lin C, Yang L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab 35(8):1457-1473.e13, 2023. e-Pub 2023. PMID: 37329887.
- Kim BJ, Zheng ZY, Lei JT, Holt MV, Chen A, Peng J, Fandino D, Singh P, Kennedy H, Dou Y, Chica-Parrado MDR, Bikorimana E, Ye D, Wang Y, Hanker AB, Mohamed N, Hilsenbeck SG, Lim B, Asirvatham JR, Sreekumar A, Zhang B, Miles G, Anurag M, Ellis MJ, Chang EC. Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor-positive Breast Cancers for Targeted Treatment. Cancer Res Commun 3(7):1366-1377, 2023. e-Pub 2023. PMID: 37501682.
- Wang M, Ding Q, Gu J, Sfamenos SM, Huo L, Tang Z, Sun H, Robinson M, Tang G, Lim B, Wu Y, Albarracin CT, Sahin AA, Chen H. Breast Cancer With a HER2 FISH Group 2 Result: Should HER2 Tests be Repeated?. Clin Breast Cancer 23(4):415-422, 2023. e-Pub 2023. PMID: 36878823.
- Abuhadra N, Sun R, Bassett RL, Huo L, Chang JT, Teshome M, Clayborn AR, White JB, Ravenberg EE, Adrada BE, Candelaria RP, Yang W, Ding Q, Symmans WF, Arun B, Damodaran S, Koenig KB, Layman RM, Lim B, Litton JK, Thompson A, Ueno NT, Piwnica-Worms H, Hortobagyi GN, Valero V, Tripathy D, Rauch GM, Moulder S, Yam C. Targeting chemotherapy resistance in mesenchymal triple-negative breast cancer: a phase II trial of neoadjuvant angiogenic and mTOR inhibition with chemotherapy. Invest New Drugs 41(3):391-401, 2023. e-Pub 2023. PMID: 37043123.
- Abuhadra N, Sun R, Yam C, Rauch GM, Ding Q, Lim B, Thompson AM, Mittendorf EA, Adrada BE, Damodaran S, Virani K, White J, Ravenberg E, Sun J, Choi J, Candelaria R, Arun B, Ueno NT, Santiago L, Saleem S, Abouharb S, Murthy RK, Ibrahim N, Sahin A, Valero V, Symmans WF, Litton JK, Tripathy D, Moulder S, Huo L. Predictive Roles of Baseline Stromal Tumor-Infiltrating Lymphocytes and Ki-67 in Pathologic Complete Response in an Early-Stage Triple-Negative Breast Cancer Prospective Trial. Cancers (Basel) 15(13), 2023. e-Pub 2023. PMID: 37444385.
- Oropeza E, Seker S, Carrel S, Mazumder A, Lozano D, Jimenez A, VandenHeuvel SN, Noltensmeyer DA, Punturi NB, Lei JT, Lim B, Waltz SE, Raghavan SA, Bainbridge MN, Haricharan S. Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness. Sci Adv 9(26):eadf2860, 2023. e-Pub 2023. PMID: 37390209.
- Hao X, Shen Y, Chen N, Zhang W, Valverde E, Wu L, Chan HL, Xu Z, Yu L, Gao Y, Bado I, Michie LN, Rivas CH, Dominguez LB, Aguirre S, Pingel BC, Wu YH, Liu F, Ding Y, Edwards DG, Liu J, Alexander A, Ueno NT, Hsueh PR, Tu CY, Liu LC, Chen SH, Hung MC, Lim B, Zhang XH. Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. Cell Stem Cell 30(5):648-664.e8, 2023. PMID: 37146584.
- Kumar T, Nee K, Wei R, He S, Nguyen QH, Bai S, Blake K, Gong Y, Pein M, Sei E, Hu M, Casasent A, Thennavan A, Li J, Tran T, Chen K, Nilges B, Kashikar N, Braubach O, Cheikh BB, Nikulina N, Chen H, Teshome M, Menegaz B, Javaid H, Nagi C, Montalvan J, Tifrea DF, Edwards R, Lin E, Parajuli R, Winocour S, Thompson A, Lim B, Lawson DA, Kessenbrock K, Navin N. A spatially resolved single cell genomic atlas of the adult human breast. bioRxiv, 2023. e-Pub 2023. PMID: 37163043.
- Baek ML, Lee J, Pendleton KE, Berner MJ, Goff EB, Tan L, Martinez SA, Mahmud I, Wang T, Meyer MD, Lim B, Barrish JP, Porter W, Lorenzi PL, Echeverria GV. Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment. Oncogene 42(14):1117-1131, 2023. e-Pub 2023. PMID: 36813854.
- Cohen EN, Jayachandran G, Gao H, Peabody P, McBride HB, Alvarez FD, Kai M, Song J, Shen Y, Willey JS, Lim B, Valero V, Ueno NT, Reuben JM. Phenotypic Plasticity in Circulating Tumor Cells Is Associated with Poor Response to Therapy in Metastatic Breast Cancer Patients. Cancers (Basel) 15(5), 2023. e-Pub 2023. PMID: 36900406.
- Wang D, Porter CE, Lim B, Rosewell Shaw A, Robertson CS, Woods ML, Xu Y, Biegert GGW, Morita D, Wang T, Grilley BJ, Heslop H, Brenner MK, Suzuki M. Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies. Sci Adv 9(13):eade6790, 2023. e-Pub 2023. PMID: 36989357.
- Lee H, Jung S, Gong G, Lim B, Lee HJ. Association of cyclooxygenase-2 expression with endoplasmic reticulum stress and autophagy in triple-negative breast cancer. PLoS One 18(8):e0289627, 2023. e-Pub 2023. PMID: 37540709.
- Chen H, Ding Q, Khazai L, Zhao L, Damodaran S, Litton JK, Rauch GM, Yam C, Chang JT, Seth S, Lim B, Thompson AM, Mittendorf EA, Adrada B, Virani K, White JB, Ravenberg E, Song X, Candelaria R, Arun B, Ueno NT, Santiago L, Saleem S, Abouharb S, Murthy RK, Ibrahim N, Routbort MJ, Sahin A, Valero V, Symmans WF, Tripathy D, Wang WL, Moulder S, Huo L. PTEN in triple-negative breast carcinoma: protein expression and genomic alteration in pretreatment and posttreatment specimens. Ther Adv Med Oncol 15:17588359231189422, 2023. e-Pub 2023. PMID: 37547448.
- Cao S, Wang JR, Ji S, Yang P, Dai Y, Guo S, Montierth MD, Shen JP, Zhao X, Chen J, Lee JJ, Guerrero PA, Spetsieris N, Engedal N, Taavitsainen S, Yu K, Livingstone J, Bhandari V, Hubert SM, Daw NC, Futreal PA, Efstathiou E, Lim B, Viale A, Zhang J, Nykter M, Czerniak BA, Brown PH, Swanton C, Msaouel P, Maitra A, Kopetz S, Campbell P, Speed TP, Boutros PC, Zhu H, Urbanucci A, Demeulemeester J, Van Loo P, Wang W. Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. Nat Biotechnol 40(11):1624-1633, 2022. e-Pub 2022. PMID: 35697807.
- Lee J, Thall PF, Lim B, Msaouel P. Utility-based Bayesian personalized treatment selection for advanced breast cancer. J R Stat Soc Ser C Appl Stat 71(5):1605-1622, 2022. e-Pub 2022. PMID: 36714159.
- Anurag M, Jaehnig EJ, Krug K, Lei JT, Bergstrom EJ, Kim BJ, Vashist TD, Huynh AMT, Dou Y, Gou X, Huang C, Shi Z, Wen B, Korchina V, Gibbs RA, Muzny DM, Doddapaneni H, Dobrolecki LE, Rodriguez H, Robles AI, Hiltke T, Lewis MT, Nangia JR, Nemati Shafaee M, Li S, Hagemann IS, Hoog J, Lim B, Osborne CK, Mani DR, Gillette MA, Zhang B, Echeverria GV, Miles G, Rimawi MF, Carr SA, Ademuyiwa FO, Satpathy S, Ellis MJ. Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer. Cancer Discov 12(11):2586-2605, 2022. PMID: 36001024.
- Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y, Yao J, Hung MC, Calin GA, Cheng J, Lim B, Lehmann LH, Salem JE, Johnson DB, Curran MA, Yu D, Han L, Darabi R, Yang L, Moslehi JJ, Lin C. Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Sci Transl Med 14(669):eabo1981, 2022. e-Pub 2022. PMID: 36322628.
- Yan G, Luna A, Wang H, Bozorgui B, Li X, Sanchez M, Dereli Z, Kahraman N, Kara G, Chen X, Zheng C, McGrail D, Sahni N, Lu Y, Babur O, Cokol M, Lim B, Ozpolat B, Sander C, Mills GB, Korkut A. BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer. Cell Rep 40(11):111304, 2022. PMID: 36103824.
- Kalra R, Chen CH, Wang J, Salam AB, Dobrolecki LE, Lewis A, Sallas C, Yates CC, Gutierrez C, Karanam B, Anurag M, Lim B, Ellis MJ, Kavuri SM. Poziotinib Inhibits HER2-Mutant-Driven Therapeutic Resistance and Multiorgan Metastasis in Breast Cancer. Cancer Res 82(16):2928-2939, 2022. PMID: 35736563.
- Haque W, Verma V, Schwartz MR, Lim B, Mangalampalli N, Butler EB, Teh BS. Neoadjuvant Chemotherapy for Metaplastic Breast Cancer: Response Rates, Management, and Outcomes. Clin Breast Cancer 22(5):e691-e699, 2022. e-Pub 2022. PMID: 35193807.
- Yam C, Abuhadra N, Sun R, Adrada BE, Ding QQ, White JB, Ravenberg EE, Clayborn AR, Valero V, Tripathy D, Damodaran S, Arun BK, Litton JK, Ueno NT, Murthy RK, Lim B, Baez L, Li X, Buzdar AU, Hortobagyi GN, Thompson AM, Mittendorf EA, Rauch GM, Candelaria RP, Huo L, Moulder SL, Chang JT. Molecular Characterization and Prospective Evaluation of Pathologic Response and Outcomes with Neoadjuvant Therapy in Metaplastic Triple-Negative Breast Cancer. Clin Cancer Res 28(13):2878-2889, 2022. PMID: 35507014.
- Shafaee MN, Makawita S, Lim B, Ellis MJ, Ludwig MS. Concurrent Chemo-radiation As a Means of Achieving Pathologic Complete Response in Triple Negative Breast Cancer. Clin Breast Cancer 22(4):e536-e543, 2022. e-Pub 2021. PMID: 35184934.
- Mouabbi JA, Hassan A, Lim B, Hortobagyi GN, Tripathy D, Layman RM. Invasive lobular carcinoma: an understudied emergent subtype of breast cancer. Breast Cancer Res Treat 193(2):253-264, 2022. e-Pub 2022. PMID: 35347549.
- Stires H, Bado I, Brown T, Carlson M, Chan IS, Echeverria GV, Ewald AJ, Lim B, Lloyd C, Maues J, Oesterreich S, Riter RN, Shanahan K, Welm AL, Newby J. Improving the odds together: a framework for breast cancer research scientists to include patient advocates in their research. NPJ Breast Cancer 8(1):75, 2022. e-Pub 2022. PMID: 35773258.
- Msaouel P, Jimenez-Fonseca P, Lim B, Carmona-Bayonas A, Agnelli G. Medicine before and after David Cox. Eur J Intern Med 98:1-3, 2022. e-Pub 2022. PMID: 35241350.
- Kim ST, Chu Y, Misoi M, Suarez-Almazor ME, Tayar JH, Lu H, Buni M, Kramer J, Rodriguez E, Hussain Z, Neelapu SS, Wang J, Shah AY, Tannir NM, Campbell MT, Gibbons DL, Cascone T, Lu C, Blumenschein GR, Altan M, Lim B, Valero V, Loghin ME, Tu J, Westin SN, Naing A, Garcia-Manero G, Abdel-Wahab N, Tawbi HA, Hwu P, Oliva ICG, Davies MA, Patel SP, Zou J, Futreal A, Diab A, Wang L, Nurieva R. Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy. Nat Commun 13(1):1970, 2022. e-Pub 2022. PMID: 35413951.
- Singh P, Lim B. Targeting Apoptosis in Cancer. Curr Oncol Rep 24(3):273-284, 2022. e-Pub 2022. PMID: 35113355.
- Masuda H, Harano K, Miura S, Wang Y, Hirota Y, Harada O, Jolly MK, Matsunaga Y, Lim B, Wood AL, Parinyanitikul N, Jin Lee H, Gong G, George JT, Levine H, Lee J, Wang X, Lucci A, Rao A, Schweitzer BL, Lawrence OR, Seitz RS, Morris SW, Hout DR, Nakamura S, Krishnamurthy S, Ueno NT. Changes in Triple-Negative Breast Cancer Molecular Subtypes in Patients Without Pathologic Complete Response After Neoadjuvant Systemic Chemotherapy. JCO Precis Oncol 6:e2000368, 2022. PMID: 35294223.
- Abuhadra N, Sun R, Litton JK, Rauch GM, Yam C, Chang JT, Seth S, Bassett R, Lim B, Thompson AM, Mittendorf E, Adrada BE, Damodaran S, White J, Ravenberg E, Candelaria R, Arun B, Ueno NT, Santiago L, Saleem S, Abouharb S, Murthy RK, Ibrahim N, Sahin AA, Valero V, Symmans WF, Tripathy D, Moulder S, Huo L. Prognostic Impact of High Baseline Stromal Tumor-Infiltrating Lymphocytes in the Absence of Pathologic Complete Response in Early-Stage Triple-Negative Breast Cancer. Cancers (Basel) 14(5), 2022. e-Pub 2022. PMID: 35267631.
- Hobbs EA, Chen N, Kuriakose A, Bonefas E, Lim B. Prognostic/predictive markers in systemic therapy resistance and metastasis in breast cancer. Ther Adv Med Oncol 14:17588359221112698, 2022. e-Pub 2022. PMID: 35860831.
- Irajizad E, Wu R, Vykoukal J, Murage E, Spencer R, Dennison JB, Moulder S, Ravenberg E, Lim B, Litton J, Tripathym D, Valero V, Damodaran S, Rauch GM, Adrada B, Candelaria R, White JB, Brewster A, Arun B, Long JP, Do KA, Hanash S, Fahrmann JF. Application of Artificial Intelligence to Plasma Metabolomics Profiles to Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer. Front Artif Intell 5:876100, 2022. e-Pub 2022. PMID: 36034598.
- Postlewait LM, Teshome M, Adesoye T, DeSnyder SM, Lim B, Kuerer HM, Bedrosian I, Sun SX, Woodward WA, Le-Petross HT, Valero V, Ueno NT, Lucci A. Contralateral Axillary Metastasis in Patients with Inflammatory Breast Cancer. Ann Surg Oncol 28(13):8610-8621, 2021. e-Pub 2021. PMID: 34125346.
- Huang X, Chen H, Ding Q, Robinson MK, Moseley TW, Bassett RL, Tang G, Lim B, Sahin AA. Clinicopathological features of and neoadjuvant therapy for human epidermal growth factor receptor 2-positive classic invasive lobular carcinoma. Hum Pathol 117:51-59, 2021. e-Pub 2021. PMID: 34363799.
- Evans KW, Yuca E, Scott SS, Zhao M, Paez Arango N, Cruz Pico CX, Saridogan T, Shariati M, Class CA, Bristow CA, Vellano CP, Zheng X, Gonzalez-Angulo AM, Su X, Tapia C, Chen K, Akcakanat A, Lim B, Tripathy D, Yap TA, Francesco MED, Draetta GF, Jones P, Heffernan TP, Marszalek JR, Meric-Bernstam F. Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer. Cancer Res 81(21):5572-5581, 2021. e-Pub 2021. PMID: 34518211.
- Kai M, Marx AN, Liu DD, Shen Y, Gao H, Reuben JM, Whitman G, Krishnamurthy S, Ross MI, Litton JK, Lim B, Ibrahim N, Kogawa T, Ueno NT. A phase II study of talimogene laherparepvec for patients with inoperable locoregional recurrence of breast cancer. Sci Rep 11(1):22242, 2021. e-Pub 2021. PMID: 34782633.
- Hester RH, Hortobagyi GN, Lim B. Inflammatory breast cancer: early recognition and diagnosis is critical. Am J Obstet Gynecol 225(4):392-396, 2021. e-Pub 2021. PMID: 33845027.
- Yam C, Yen EY, Chang JT, Bassett RL, Alatrash G, Garber H, Huo L, Yang F, Philips AV, Ding QQ, Lim B, Ueno NT, Kannan K, Sun X, Sun B, Parra Cuentas ER, Symmans WF, White JB, Ravenberg E, Seth S, Guerriero JL, Rauch GM, Damodaran S, Litton JK, Wargo JA, Hortobagyi GN, Futreal A, Wistuba II, Sun R, Moulder SL, Mittendorf EA. Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer. Clin Cancer Res 27(19):5365-5375, 2021. PMID: 34253579.
- Lim B, Peterson CB, Davis A, Cho E, Pearson T, Liu H, Hwang M, Ueno NT, Lee J. ONC201 and an MEK Inhibitor Trametinib Synergistically Inhibit the Growth of Triple-Negative Breast Cancer Cells. Biomedicines 9(10), 2021. e-Pub 2021. PMID: 34680527.
- Allen JE, Kline CLB, Prabhu VV, Wagner J, Ishizawa J, Madhukar N, Lev A, Baumeister M, Zhou L, Lulla A, Stogniew M, Schalop L, Benes C, Kaufman HL, Pottorf RS, Nallaganchu BR, Olson GL, Al-Mulla F, Duvic M, Wu GS, Dicker DT, Talekar MK, Lim B, Elemento O, Oster W, Bertino J, Flaherty K, Wang ML, Borthakur G, Andreeff M, Stein M, El-Deiry WS. Correction: Discovery and clinical introduction of first-in-class imipridone ONC201. Oncotarget 12(21):2231, 2021. e-Pub 2021. PMID: 34676056.
- Wang K, Xiao Z, Yan Y, Ye R, Hu M, Bai S, Sei E, Qiao Y, Chen H, Lim B, Lin SH, Navin NE. Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility. Mol Cell 81(20):4319-4332.e10, 2021. PMID: 34686316.
- Partain N, Postlewait LM, Teshome M, Rosso K, Hall C, Song J, Meas S, DeSnyder SM, Lim B, Valero V, Woodward W, Ueno NT, Kuerer H, Lucci A. The Role of Mastectomy in De Novo Stage IV Inflammatory Breast Cancer. Ann Surg Oncol 28(8):4265-4274, 2021. e-Pub 2021. PMID: 33403525.
- Lim B. PD-L1 in Breast Cancer: The Road to the Perfect BiomarkerIs Fraught With Uncertainty. J Natl Cancer Inst 113(8):951-952, 2021. PMID: 33523229.
- Yennurajalingam S, Carmack C, Balachandran D, Eng C, Lim B, Delgado M, Guzman Gutierrez D, Raznahan M, Park M, Hess KR, Williams JL, Lu Z, Ochoa J, Bruera E. Sleep disturbance in patients with cancer: a feasibility study of multimodal therapy. BMJ Support Palliat Care 11(2):170-179, 2021. e-Pub 2020. PMID: 31924662.
- Cerna D, Lim B, Adelabu Y, Yoo S, Carter D, Fahim A, Mitsuuchi Y, Teicher BA, Bernhard E, Coleman CN, Takebe N, Ahmed MM. SMAC Mimetic/IAP Inhibitor Birinapant Enhances Radiosensitivity of Glioblastoma Multiforme. Radiat Res 195(6):549-560, 2021. PMID: 33826739.
- Lim B, Potter DA, Salkeni MA, Silverman P, Haddad TC, Forget F, Awada A, Canon JL, Danso M, Lortholary A, Bourgeois H, Tan-Chiu E, Vincent S, Bahamon B, Galinsky KJ, Patel C, Neuwirth R, Leonard EJ, Diamond JR. Sapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor-Positive/HER2-Negative Advanced or Metastatic Breast Cancer. Clin Cancer Res 27(12):3329-3338, 2021. e-Pub 2021. PMID: 33820779.
- Lee J, Liu H, Pearson T, Iwase T, Fuson J, Lalani AS, Eli LD, Diala I, Tripathy D, Lim B, Ueno NT. PI3K and MAPK Pathways as Targets for Combination with the Pan-HER Irreversible Inhibitor Neratinib in HER2-Positive Breast Cancer and TNBC by Kinome RNAi Screening. Biomedicines 9(7), 2021. e-Pub 2021. PMID: 34203351.
- Yam C, Rauch GM, Rahman T, Karuturi M, Ravenberg E, White J, Clayborn A, McCarthy P, Abouharb S, Lim B, Litton JK, Ramirez DL, Saleem S, Stec J, Symmans WF, Huo L, Damodaran S, Sun R, Moulder SL. A phase II study of Mirvetuximab Soravtansine in triple-negative breast cancer. Invest New Drugs 39(2):509-515, 2021. e-Pub 2020. PMID: 32984932.
- Minussi DC, Nicholson MD, Ye H, Davis A, Wang K, Baker T, Tarabichi M, Sei E, Du H, Rabbani M, Peng C, Hu M, Bai S, Lin YW, Schalck A, Multani A, Ma J, McDonald TO, Casasent A, Barrera A, Chen H, Lim B, Arun B, Meric-Bernstam F, Van Loo P, Michor F, Navin NE. Breast tumours maintain a reservoir of subclonal diversity during expansion. Nature 592(7853):302-308, 2021. e-Pub 2021. PMID: 33762732.
- Sun H, Chen H, Crespo J, Tang G, Robinson M, Lim B, Sahin AA. Clinicopathological Features of Breast Cancer with Polysomy 17 and Its Response to Neoadjuvant Chemotherapy. Eur J Breast Health 17(2):128-136, 2021. e-Pub 2021. PMID: 33870112.
- Chainitikun S, Saleem S, Lim B, Valero V, Ueno NT. Update on systemic treatment for newly diagnosed inflammatory breast cancer. J Adv Res 29:1-12, 2021. e-Pub 2020. PMID: 33842000.
- Lim B, Song J, Ibrahim NK, Koenig KB, Chavez-MacGregor M, Ensor JE, Gomez JS, Krishnamurthy S, Caudle AS, Shaitelman SF, Whitman GJ, Valero V. A Randomized Phase II Study of Sequential Eribulin Versus Paclitaxel Followed by FAC/FEC as Neoadjuvant Therapy in Patients with Operable HER2-Negative Breast Cancer. Oncologist 26(2):e230-e240, 2021. e-Pub 2020. PMID: 33140515.
- Chainitikun S, Espinosa Fernandez JR, Long JP, Iwase T, Kida K, Wang X, Saleem S, Lim B, Valero V, Ueno NT. Pathological complete response of adding targeted therapy to neoadjuvant chemotherapy for inflammatory breast cancer: A systematic review. PLoS One 16(4):e0250057, 2021. e-Pub 2021. PMID: 33861773.
- Postlewait LM, Teshome M, DeSnyder SM, Lim B, Kuerer HM, Bedrosian I, Woodward WA, Ueno NT, Lucci A. Factors Associated with Pathological Node Negativity in Inflammatory Breast Cancer: Are There Patients Who May be Candidates for a De-Escalation of Axillary Surgery?. Ann Surg Oncol 27(12):4603-4612, 2020. e-Pub 2020. PMID: 32710271.
- Li P, Lu M, Shi J, Gong Z, Hua L, Li Q, Lim B, Zhang XH, Chen X, Li S, Shultz LD, Ren G. Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis. Nat Immunol 21(11):1444-1455, 2020. e-Pub 2020. PMID: 32958928.
- Kida K, Hess KR, Lim B, Iwase T, Chainitikun S, Valero V, Lucci A, Le-Petross HC, Woodward WA, Krishnamurthy S, Hortobagyi GN, Tripathy D, Ueno NT. Validation of Prognostic Stage and Anatomic Stage in the American Joint Committee on Cancer 8th Edition for Inflammatory Breast Cancer. Cancers (Basel) 12(11), 2020. e-Pub 2020. PMID: 33114311.
- Wang X, Semba T, Phi LTH, Chainitikun S, Iwase T, Lim B, Ueno NT. Targeting Signaling Pathways in Inflammatory Breast Cancer. Cancers (Basel) 12(9), 2020. e-Pub 2020. PMID: 32883032.
- Kogawa T, Fujii T, Wu J, Harano K, Fouad TM, Liu DD, Shen Y, Masuda H, Krishnamurthy S, Chavez-MacGregor M, Lim B, Murthy RK, Valero V, Tripathy D, Ueno NT. Prognostic Value of HER2 to CEP17 Ratio on Fluorescence In Situ Hybridization Ratio in Patients with Nonmetastatic HER2-Positive Inflammatory and Noninflammatory Breast Cancer Treated with Neoadjuvant Chemotherapy with or without Trastuzumab. Oncologist 25(6):e909-e919, 2020. e-Pub 2020. PMID: 32003919.
- Milbury K, Weathers SP, Durrani S, Li Y, Whisenant M, Li J, Lim B, Weinberg JS, Kesler SR, Cohen L, Bruera E. Online Couple-Based Meditation Intervention for Patients With Primary or Metastatic Brain Tumors and Their Partners: Results of a Pilot Randomized Controlled Trial. J Pain Symptom Manage 59(6):1260-1267, 2020. e-Pub 2020. PMID: 32061834.
- Lim B, Lin Y, Navin N. Advancing Cancer Research and Medicine with Single-Cell Genomics. Cancer Cell 37(4):456-470, 2020. PMID: 32289270.
- Ueno NT, Tahara RK, Fujii T, Reuben JM, Gao H, Saigal B, Lucci A, Iwase T, Ibrahim NK, Damodaran S, Shen Y, Liu DD, Hortobagyi GN, Tripathy D, Lim B, Chasen BA. Phase II study of Radium-223 dichloride combined with hormonal therapy for hormone receptor-positive, bone-dominant metastatic breast cancer. Cancer Med 9(3):1025-1032, 2020. e-Pub 2019. PMID: 31849202.
- Espinosa Fernandez JR, Eckhardt BL, Lee J, Lim B, Pearson T, Seitz RS, Hout DR, Schweitzer BL, Nielsen TJ, Lawrence OR, Wang Y, Rao A, Ueno NT. Identification of triple-negative breast cancer cell lines classified under the same molecular subtype using different molecular characterization techniques: Implications for translational research. PLoS One 15(4):e0231953, 2020. e-Pub 2020. PMID: 32353087.
- Crespo J, Sun H, Wu J, Ding QQ, Tang G, Robinson MK, Chen H, Sahin AA, Lim B. Rate of reclassification of HER2-equivocal breast cancer cases to HER2-negative per the 2018 ASCO/CAP guidelines and response of HER2-equivocal cases to anti-HER2 therapy. PLoS One 15(11):e0241775, 2020. e-Pub 2020. PMID: 33180796.
- Lim B, Greer Y, Lipkowitz S, Takebe N.. Novel Apoptosis-Inducing Agents for the Treatment of Cancer, a New Arsenal in the Toolbox. Cancers (Basel), 2019. e-Pub 2019.
- Ding Q, Chen H, Lim B, Damodaran S, Chen W, Tripathy D, Piha-Paul S, Luthra R, Meric-Bernstam F, Sahin AA.. HER2 somatic mutation analysis in breast cancer: correlation with clinicopathological features. Human Pathol, 2019.
- Lee J, Lim B, Pearson T, Choi K, Fuson JA, Bartholomeusz C, Paradiso LJ, Myers T, Tripathy D, Ueno NT. Correction to: Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer. Breast Cancer Res Treat 176(1):251, 2019. PMID: 30982934.
- Candelaria RP, Adrada BE, Wei W, Thompson AM, Santiago L, Lane DL, Huang ML, Arribas EM, Rauch GM, Symmans WF, Gilcrease MZ, Huo L, Lim B, Ueno NT, Moulder SL, Yang WT. Imaging features of triple-negative breast cancers according to androgen receptor status. Eur J Radiol 114:167-174, 2019. e-Pub 2019. PMID: 31005169.
- Lim B, Murthy RK, Lee J, Jackson SA, Iwase T, Davis DW, Willey JS, Wu J, Shen Y, Tripathy D, Alvarez R, Ibrahim NK, Brewster AM, Barcenas CH, Brown PH, Giordano SH, Moulder SL, Booser DJ, Moscow JA, Piekarz R, Valero V, Ueno NT. A phase Ib study of entinostat plus lapatinib with or without trastuzumab in patients with HER2-positive metastatic breast cancer that progressed during trastuzumab treatment. Br J Cancer. e-Pub 2019. PMID: 31097774.
- Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers (Basel) 11(5), 2019. e-Pub 2019. PMID: 31137625.
- Lee J, Lim B, Pearson T, Choi K, Fuson JA, Bartholomeusz C, Paradiso LJ, Myers T, Tripathy D, Ueno NT. Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer. Breast Cancer Res Treat. e-Pub 2019. PMID: 30826934.
- Kang S, Kim EH, Hwang JE, Shin JH, Jeong YS, Yim SY, Joo EW, Eun YG, Lee DJ, Sohn BH, Lee SH, Lim B, Lee JS. Prognostic significance of high metabolic activity in breast cancer: PET signature in breast cancer. Biochem Biophys Res Commun 511(1):185-191, 2019. e-Pub 2019. PMID: 30777332.
- Menta A, Fouad TM, Lucci A, Le-Petross H, Stauder MC, Woodward WA, Ueno NT, Lim B,. Inflammatory Breast Cancer: What to Know About This Unique, Aggressive Breast Cancer. Surg Clin North Am 98(4):787-800, 2018. e-Pub 2018. PMID: 30005774.
- Murthy RK, Raghavendra AS, Hess KR, Fujii T, Lim B, Barcenas CH, Zhang H, Chavez-Mac-Gregor M, Mittendorf EA, Litton JK, Giordano SH, Thompson AM, Valero V, Moulder SL, Tripathy D, Ueno NT. Neoadjuvant Pertuzumab-containing Regimens Improve Pathologic Complete Response Rates in Stage II to III HER-2/neu-positive Breast Cancer: A Retrospective, Single Institution Experience. Clin Breast Cancer. e-Pub 2018. PMID: 30077429.
- Lim B, Matsuda N, Wang X, Krishnamurthy S, Alvarez RH, Willey JS, Parker CA, Song J, Shen Y, Hu J, Wu W, Li N, Babiera GV, Murray JL, Arun BK, Brewster AM, Reuben JM, Stauder MC, Barnett CM, Woodward WA, Le-Petross HTC, Lucci A, DeSnyder SM, Tripathy D, Valero V, Ueno NT. Safety and Efficacy of Panitumumab Plus Neoadjuvant Chemotherapy in Patients With Primary HER2-Negative Inflammatory Breast Cancer. JAMA Oncol. e-Pub 2018. PMID: 29879283.
- Kogawa T, Fujii T, Fouad TM, Liu DD, Harano K, Masuda H, Iwase T, Barnett C, Park YS, Lim B, Tripathy D, Litton JK, Ueno NT. Impact of change in body mass index during neoadjuvant chemotherapy and survival among breast cancer subtypes. Breast Cancer Res Treat. e-Pub 2018. PMID: 29915946.
- Le-Petross HT, Lim B,. Role of MR Imaging in Neoadjuvant Therapy Monitoring. Magn Reson Imaging Clin N Am 26(2):207-220, 2018. e-Pub 2018. PMID: 29622126.
- Lim B, Woodward WA, Wang X, Reuben JM, Ueno NT. Inflammatory breast cancer biology: the tumour microenvironment is key. Nat Rev Cancer. e-Pub 2018. PMID: 29703913.
- Uemura MI, French JT, Hess KR, Liu D, Raghav K, Hortobagyi GN, Arun BK, Valero V, Ueno NT, Alvarez RH, Woodward WA, Debeb BG, Moulder SL, Lim B, Tripathy D, Ibrahim NK. Development of CNS metastases and survival in patients with inflammatory breast cancer. Cancer. e-Pub 2018. PMID: 29579338.
- He J, Huo L, Ma J, Zhao J, Bassett RL, Sun X, Ueno NT, Lim B, Gong Y. Expression of Programmed Death Ligand 1 (PD-L1) in Posttreatment Primary Inflammatory Breast Cancers and Clinical Implications. Am J Clin Pathol. e-Pub 2018. PMID: 29425258.
- Yamauchi T, Espinosa Fernandez JR, Imamura CK, Yamauchi H, Jinno H, Takahashi M, Kitagawa Y, Nakamura S, Lim B, Krishnamurthy S, Reuben JM, Liu D, Tripathy D, Chen H, Takebe N, Saya H, Ueno NT. Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer. Oncotarget 9(6):6872-6882, 2018. e-Pub 2018. PMID: 29467936.
- Ueno NT, Espinosa Fernandez JR, Cristofanilli M, Overmoyer B, Rea D, Berdichevski F, El-Shinawi M, Bellon J, Le-Petross HT, Lucci A, Babiera G, DeSnyder SM, Teshome M, Chang E, Lim B, Krishnamurthy S, Stauder MC, Parmar S, Mohamed MM, Alexander A, Valero V, Woodward WA. International Consensus on the Clinical Management of Inflammatory Breast Cancer from the Morgan Welch Inflammatory Breast Cancer Research Program 10th Anniversary Conference. J Cancer 9(8):1437-1447, 2018. e-Pub 2018. PMID: 29721054.
- Harano K, Wang Y, Lim B, Seitz RS, Morris SW, Bailey DB, Hout DR, Skelton RL, Ring BZ, Masuda H, Rao AUK, Laere SV, Bertucci F, Woodward WA, Reuben JM, Krishnamurthy S, Ueno NT. Rates of immune cell infiltration in patients with triple-negative breast cancer by molecular subtype. PLoS One 13(10):e0204513, 2018. e-Pub 2018. PMID: 30312311.
- Fujii T, Kogawa T, Dong W, Sahin AA, Moulder S, Litton JK, Tripathy D, Iwamoto T, Hunt KK, Pusztai L, Lim B, Shen Y, Ueno NT. Revisiting the definition of estrogen receptor positivity in HER2-negative primary breast cancer. Ann Oncol 28(10):2420-2428, 2017. PMID: 28961844.
- Harano K, Kogawa T, Wu J, Yuan Y, Cohen EN, Lim B, Reuben JM, Ueno NT.. Thrombocytosis as a prognostic factor in inflammatory breast cancer. Breast Cancer Res Treat, 2017. e-Pub 2017. PMID: 28831670.
- Oualla K, El-Zawahry HM, Arun B, Reuben JM, Woodward WA, Gamal El-Din H, Lim B, Mellas N, Ueno NT, Fouad T. Novel therapeutic strategies in the treatment of triple-negative breast cancer. Ther Adv Med Oncol 7(493-511), 2017. PMID: 28717401.
- Sato N, Wakabayashi M, Nakatsuji M, Shimoji N, Sakamoto S, Ishida A, Lee J, Lim B, Ueno NT, Ishihara H, Inui T. MEK and PI3K catalytic activity as predictor of the response to molecularly targeted agents in triple-negative breast cancer. Biochem Biophys Res Commun, 2017. PMID: 28576487.
- Matsuda N, Lim B, Wang X, Ueno NT. Early clinical development of epidermal growth factor receptor targeted therapy in breast cancer. Expert Opin Investig Drugs 26(4):1-17, 2017. e-Pub 2017. PMID: 28271910.
- Fouad TM, Barrera AM, Reuben JM, Lucci A, Woodward WA, Stauder MC, Lim B, DeSnyder SM, Arun B, Gildy B, Valero V, Hortobagyi GN, Ueno NT. Inflammatory breast cancer: a proposed conceptual shift in the UICC-AJCC TNM staging system. Lancet Oncol 18(4):e228-e232, 2017. PMID: 28368261.
- Ralff MD, Kline CLB Küçükkase OC, Wagner J, Lim B, Dicker DT, Prabhu VV, Oster W, El-Deiry WS. ONC201 demonstrates anti-tumor effects in both triple negative and non-triple negative breast cancers through TRAIL-dependent and TRAIL-independent mechanisms. Molecular Cancer Therapeutics, 2017.
- Kono M, Fujii T, Lim B, Karuturi MS, Tripathy D, Ueno N. Androgen Receptor Function and Androgen Receptor-Targeted Therapies in Breast Cancer: A Review. JAMA Oncol. e-Pub 2017. PMID: 28301631.
- Matsuda N, Lim B, Wang Y, Krishnamurthy S, Woodward W, Alvarez RH, Lucci A, Valero V, Reuben JM, Meric-Bernstam F, Ueno NT. Identification of frequent somatic mutations in inflammatory breast cancer. Breast Cancer Res Treat. e-Pub 2017. PMID: 28243898.
- Torres-Adorno AM, Lee J, Kogawa T, Ordentlich P, Tripathy D, Lim B, Ueno NT.. Histone deacetylase inhibitor enhances the efficacy of MEK inhibitor through NOXA-mediated MCL1 degradation in triple-negative and inflammatory breast cancer. Clin Cancer Res, 2017.
- Fujii T, Reuben JM, Huo L, Espinosa Fernandez JR, Gong Y, Krupa R, Suraneni MV, Graf RP, Lee J, Greene S, Rodriguez A, Dugan L, Louw J, Lim B, Barcenas CH, Marx AN, Tripathy D, Wang Y, Landers M, Dittamore R, Ueno NT. Androgen receptor expression on circulating tumor cells in metastatic breast cancer. PLoS One 12(9):e0185231, 2017. e-Pub 2017. PMID: 28957377.
- Lim B, Hortobagyi GN. Current challenges of metastatic breast cancer. Cancer Metastasis Rev 35(4):495-514, 2016. e-Pub 2016. PMID: 27933405.
- Allen JE, Kline CL, Prabhu VV, Wagner J, Ishizawa J, Madhukar N, Lev A, Baumeister M, Zhou L, Lulla A, Stogniew M, Schalop L, Benes C, Kaufman HL, Pottorf RS, Nallaganchu BR, Olson GL, Al-Mulla F, Duvic M, Wu GS, Dicker DT, Talekar MK, Lim B, Elemento O, Oster W, Bertino J, Flaherty K, Wang ML, Borthakur G, Andreeff M, Stein M, El-Deiry WS. Discovery and clinical introduction of first-in-class imipridone ONC201. Oncotarget 7(45):74380-74392, 2016. e-Pub 2016. PMID: 27602582.
- Matthew EM, Zhou L, Yang Z, Dicker DT, Holder SL, Lim B, Harouaka R, Zheng SY, Drabick JJ, Lamparella NE, Truica CI, El-Deiry WS. A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells. Oncotarget 7(4):3662-76, 2016. e-Pub 2015. PMID: 26695546.
- Le Du F, Eckhardt BL, Lim B, Litton JK, Moulder S, Meric-Bernstam F, Gonzalez-Angulo AM, Ueno NT. Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype?. Oncotarget 6(15):12890-12908, 2015. e-Pub 2015. PMID: 25973541.
- Allen JE, Prabhu V, Talekar M, van den Heuvel AP, Lim B, Dicker DT, Fritz JL, Beck A, El-Deiry WS. Genetic and pharmacological screens converge in identifying FLIP, BCL2 and IAP proteins as key regulators of sensitivity to the TRAIL-Inducing anticancer agent ONC201/TIC10. Cancer Res 75(8):1668-74, 2015. e-Pub 2015. PMID: 25681273.
- Ma Y, Hao S, Wang S, Zhao Y, Lim B, Lei M, Spector DJ, El-Deiry WS, Zheng SY, Zhu J. A Combinatory Strategy for Detection of Live CTCs Using Microfiltration and a New Telomerase-Selective Adenovirus. Mol Cancer Ther 14(3):835-43, 2015. e-Pub 2015. PMID: 25589497.
- Lee HJ, Song IH, Seo AN, Lim B, Kim JY, Lee JJ, Park IA, Shin J, Yu JH, Ahn JH, Gong G. Correlations Between Molecular Subtypes and Pathologic Response Patterns of Breast Cancers After Neoadjuvant Chemotherapy. Ann Surg Oncol 22(2):392-400, 2015. e-Pub 2014. PMID: 25192679.
- Lim B, Allen JE, Prabhu VV, Talekar MK, Finnberg NK, El-Deiry WS. Targeting TRAIL in the treatment of cancer: new developments. Expert Opin Ther Targets 25(9):1-15, 2015. e-Pub 2015. PMID: 26004811.
- Brennan M, Lim B. The Actual Role of Receptors as Cancer Markers, Biochemical and Clinical Aspects: Receptors in Breast Cancer. Adv Exp Med Biol 867:327-37, 2015. PMID: 26530375.
- Lim B, Jiang Y. Current and Emerging Systemic Therapy in Gastro-Esophageal Cancer "The Old and New Therapy for Metastatic Disease, The Role of Adjuvant and Neoadjuvant Therapy for Localized Disease". Curr Clin Pharmacol 10(4):267-78, 2015. PMID: 26548904.
- El-Deiry WS, Vijayvergia N, Xiu J, Scicchitano A, Lim B, Yee NS, Harvey HA, Gatalica Z, Reddy S. Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites. Cancer Biol Ther 16(12):0, 2015. e-Pub 2015. PMID: 26553611.
- Lee J, Galloway R, Grandjean G, Jacob J, Humphries J, Bartholomeusz C, Goodstal S, Lim B, Bartholomeusz G, Ueno NT, Rao A. Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer. J Cancer 6(12):1306-19, 2015. e-Pub 2015. PMID: 26640591.
- Lee HJ, Park IA, Park SY, Seo AN, Lim B, Chai Y, Song IH, Kim NE, Kim JY, Yu JH, Ahn JH, Gong G. Two histopathologically different diseases: hormone receptor-positive and hormone receptor-negative tumors in HER2-positive breast cancer. Breast Cancer Res Treat 145(3):615-23, 2014. e-Pub 2014. PMID: 24820412.
- Miller E, Lee HJ, Lulla A, Hernandez L, Gokare P, Lim B. Current treatment of early breast cancer: adjuvant and neoadjuvant therapy. F1000Res 3:198, 2014. e-Pub 2014. PMID: 25400908.
- Lim B, Scicchitano A, Beachler C, Gusani N, Sarwani N, Yang Z, Staveley-O'Carroll K, Ashkenazi A, Portera C, El-Deiry WS. FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer. Cancer Biol Ther 14(8):711-9, 2013. e-Pub 2013. PMID: 23792567.
- Lim B, Cream LV, Harvey HA. Update on clinical trials: genetic targets in breast cancer. Adv Exp Med Biol 779:35-54, 2013. PMID: 23288634.
Invited Articles
- Finnberg NK, Lim B. Predicting response to EGFR-targeting mAb in CRC – is the KRAS mutation test sufficient?. PMO 2(8):430-6, 2013.
Manuals, Teaching Aids, Other Teaching Publications
- Milbury K, Weathers S-P, Durrani S, Li Y, Whisenant M, Li J, Lim B. Educational Exchange. jpsmjournal.com, 2020.
Other Articles
- Lee J, Lim B, Ueno NT VOICES: MD Anderson's EDGE Preclinical Solutions Program—Aiming to Overcome Challenges of Preclinical Research for Breast Cancer Early Drug Development. Oncology Times 37(24):36-7, 2015.
Editorials
- Lim B. Tumor Biology Correlates With Rates of Breast-Conserving Surgery and Pathologic Complete Response After Neoadjuvant Chemotherapy for Breast Cancer: Findings From The ACOSOG Z1071 (Alliance) Prospective Multicenter Clinical Trial. Breast Diseases: a YB Quarterly 26(3).
Abstracts
- Moulder SL, Bassett RL, White JB, Huo L, Damodaran S, Lim B, Ueno NT, Murthy RK, Arun B, Valero V, Tripathy D, Hortobagyi GN, Litton JK, Thompson AM, Mittendorf EA, Ravenberg E, Santiago L, Adrada BE, Candelaria RP, Rauch GM. Statistical modeling of a novel clinical trial design using neoadjuvant therapy (NAT) to personalize therapy in patients (pts) with triple-negative breast cancer (TNBC). J Clin Oncol 38(15_suppl):595, 2020.
- Basho RK, Yam C, White JB, Zhao L, Huo L, Mittendorf EA, Thompson AM, Litton JK, Arun B, Lim B, Valero V, Tripathy D, Zhang J, Adrada BE, Santiago L, Ravenberg E, Moulder SL, Damodaran S. Incidence of PI3K pathway alteration and response to neoadjuvant therapy (NAT) in triple negative breast cancer (TNBC) subtypes. J Clin Oncol 38(15_Suppl), 2020.
- Lim B, Seth S, Huo L, Layman RM, Valero V, Thompson AM, White JB, Litton JK, Damodaran S, Candelaria RP, Arun B, Rauch GM, Murthy RK, Ding Q, Symmans WF, Zhao L, Zhang J, Tripathy D, Moulder SL, Ueno NT. Comprehensive profiling of androgen receptor-positive (AR+) triple-negative breast cancer (TNBC) patients (pts) treated with standard neoadjuvant therapy (NAT)+/-enzalutamide. J Clin Oncol 38(15_Suppl), 2020.
- Abuhadra N, Sun R, Litton JK, Rauch GM, Thompson AM, Lim B, Adrada BE, Mittendorf EA, White JB, Ravenberg E, Damodaran S, Candelaria RP, Arun B, Ueno NT, Santiago L, Murhy RK, Ibrahim NK, Symmans WF, Moulder SL, Huo L. Prognostic impact of high stromal tumor-infiltrating lymphocytes (sTIL) in the absence of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in early stage triple negative breast cancer (TNBC). J Clin Oncol 38(15_Suppl), 2020.
- Abuhadra N, Sun R, Litton JK, Rauch GM, Thompson AM, Lim B, Adrada BE, Mittendorf EA, Damodaran S, Pitpitan R, Arun B, White JB, Ravenberg E, Santiago L, Sahin AA, Murthy RK, Ueno NT, Ibrahim NK, Mloulder SL, Huo L. The immunomodulatory (IM) signature enhances prediction of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in triple negative breast cancers (TNBC) with moderate stromal tumour infiltrating lymphocytes (sTIL). Ann Oncol 31(Suppl_2), 2020.
- Evans K, Moulder S, Yuca E, Scott S, Arango NP, Shariati M, Vellano CP, Saridogan T, Zheng X, Gonzalez-Argulo AM, Zhao M, Su X, Tapia C, Chen K, Akcakanat A, Perou CM, Lim B, Tripathy D, Yap TA, Francesco ME, Draetta PJ, Marszalek J, Meric-Bernstam F. Abstract C016: Oxidative phosphorylation is a metabolic vulnerability in chemotherapy resistant triple negative breast cancer. Mol Cancer Ther 18(C016), 2019.
- Crespo J, Sun H, Wu J, Ding Q, Tang G, Robinson M, Chen H, Sahin AA, Lim B. HER2 targeted therapy and outcome in HER2-equivocal cases after 2018 ASCO/CAP HER2 guideline modification. J Clin Oncol 37(15_Suppl), 2019. e-Pub 2019.
- Winer A, Vijayvergia N, Cohen SJ, Denlinger CS, Astsaturov IA, Dotan E, Gallant J-N, Wang EW, Kunkel M, Lim B, Harvey HA, Sivik JM, Zhou L, Korzekwa K, Ruth K, Ross EA, El-Deiry WS. A phase ib trial to evaluate the safety and efficacy of quinacrine plus capecitabine in patients with refractory metastatic colorectal cancer. J Clin Oncol 37(15_Suppl), 2019. e-Pub 2019.
- Seth S, Crespo J, Huo L, Thompson AM, Mittendorf EA, Hess KR, Litton JK, Rauch GM, Adrada BE, Damodaran S, Candelaria RP, Arun B, Yang WT, Santiago L, Murthy RK, Sahin AA, Symmans WF, Moulder SL, Ueno NT, Lim B. Evaluation of predictive biomarkers for AR therapy and to identify the LAR subtype of TNBC. J Clin Oncol 37(15_Suppl), 2019. e-Pub 2019.
- Abuhadra N, Hess KR, Litton JK, Rauch GM, Thompson AM, Lim B, Adrada BE, Mittendorf EA, Damodaran S, Candelaria RP, Arun B, Yang WT, Ueno NT, Santiago L, Murthy RK, Ibrahim NK, Sahin AA, Symmans WF, Moulder SL, Huo L. Beyond TILs: Predictors of pathologic complete response (pCR) in triple-negative breast cancer (TNBC) patients with moderate tumor-infiltrating lymphocytes (TIL) receiving neoadjuvant chemotherapy. J Clin Oncol 37(15_Suppl), 2019.
- Yennu S, Valero V, Lim B, Booser DJ, Hernandez CDH, Lu Z, Liu DD, Busaidy NL, Reuben JM, Williams JL, Hess KR, Basen-Enuquist KB, Bruera E. High/low dose dexamethasone with physical activity for cancer-related fatigue in patients with advanced cancer: A phase II randomized double blind study. J Clin Oncol 37(15_Suppl), 2019.
- Karakas B, Jean SR, Narovlyansky M, Kumar S, Gillies S, Krajewski S, Lim B, Cardone M. Identifying Bcl-2 family protein dependencies in tumors using dimerization specific antibody biomarkers as a method for predicting response to apoptosis inducing therapies. Cancer Res 79(13_suppl):3164, 2019.
- Moulder SL, Adrada B, Lim B, Ueno NT, Candelaria RM, Rauch G, Litton JK, Thompson AM, Huo L, Hess KR. A model using easily evaluated clinical features to identify triple negative breast cancer (TNBC) patients (pts) with high probability of achieving pathologic complete response. The Breast 44:S101-102, 2019.
- H Masuda, S Miura, K Harano, Y Wang, Y Hirota, Y Matsunaga, Lim B, A Lucci, N Parinyanitikul, HJ Lee, G Gong, A Rao, RS Seitz, SW Morris, DR Hout, S Nakamura, D Tripathy, O Harada, S Krishnamurthy, NT Ueno. Abstract P4-02-05: Apocrine morphology and LAR molecular subtype predict prognosis of TNBC patients with residual disease after neoadjuvant chemotherapy. Cancer Res 79(4_Suppl), 2019.
- Murthy RK, Raghavendra AS, Hess KR, Barcenas CH, Lim B, Moulder SL, Giordano SH, Mittendorf EA, Thompson A, Ueno NT, Valero V, Litton JK, Tripathy D, Chavez-Macgregor M. Abstract P6-17-04: 3-year relapse-free survival of stage II-III HER2-neu positive breast cancer treated with pertuzumab and trastuzumab-containing neoadjuvant therapy compared to trastuzumab-containing therapy. Cancer Res 79(4_Suppl), 2019.
- Kida K, Lee J, Liu H, Lim B, Murthy RK, Sahin AA, Tripathy D, Ueno NT. Abstract P3-10-23: Changes in the expression of HER2 and other genes in HER2-positive metastatic breast cancer induced by treatment with ado-trastuzumab emtansine and/or pertuzumab/trastuzumab. Cancer Res 79(4_Suppl), 2019.
- Ueno NT, Tahara RK, Reuben JM, Gao H, Saigal B, Fujii T, Lucci A, Ibrahim NK, Damodaran S, Shen Y, Liu DD, Hortobagyi GN, Tripathy D, Lim B, BA Chasen. Abstract P1-18-04: CTCs and SUV to predict the efficacy of the bone-specific radiopharmaceutical agent radium-223 dichloride combined with hormonal therapy for hormone receptor-positive bone-dominant breast cancer metastasis. Cancer Res 79(4_Suppl), 2019.
- Yam C, Raghavendra A, Hess KR, Adrada BE, Candelaria RP, Damodaran S, Gilcrease MZ, Helgason T, Hortobagyi GN, Huo L, Layman RM, Lim B, Litton JK, Mittendorf EA, Murthy RK, Piwnica-Worms H, Rauch GM, Santiago L, Symmans WF, Thompson AM, Tripathy D, Ueno NT, Valero V, Barcenas CH, Moulder SL, Yang W. Abstract P1-15-06: Impact of serial biopsies in triple-negative breast cancer patients receiving neoadjuvant systemic therapy. Cancer Res 79(4_Suppl), 2019.
- Alexander A, Marx AN, Reddy SM, Ruben JM, Le-Petross HC, Lane D, Huang ML, Krishnamurthy S, Gong Y, Gombos DS, Patel N, Tung CI, Allen RC, Kandl TJ, Wu J, Liu S, Patel AB, Futreal A, Wistuba I, Layman RM, Valero V, Tripathy D, Ueno NT, Lim B. Abstract OT3-05-04: Phase II study of atezolizumab, cobimetinib, and eribulin in patients with recurrent or metastatic inflammatory breast cancer (IBC). Cancer Res 79(4 Suppl), 2019.
- Murthy RK, Raghavendra AS, Hess KR, Fujii T, Lim B, Barcenas CH, Zhang H, Chavez-Mac-Gregor M, Mittendorf EA, Litton JK, Giordano SH, Thompson AM, Valero V, Moulder SL, Tripathy D, Ueno NT. Neoadjuvant Pertuzumab-containing Regimens Improve Pathologic Complete Response Rates in Stage II to III HER-2/neu-positive Breast Cancer: A Retrospective, Single Institution Experience. Clin Breast Cancer 18(6), 2018.
- Chang N, Chen H, Al-Awadhi AM, Tang G, Robinson MK, Lim B, Sahin A. Equivocal HER2/neu FISH Results in Breast Cancer: How Frequently Do They Change on Repeat Testing?. Laboratory Investigation 98:53, 2018.
- Al-Awadhi A, Kono M, Marx A, Moseley T, Willey J, Sun H, Fu M, Whitman GJ, Valero V, Ueno NT, Lim B. Abstract OT2-07-09: A phase Ib study of neratinib, pertuzumab, and trastuzumab with paclitaxel in patients with metastatic and locally advanced breast cancer. Cancer Res 78(4_Suppl), 2018.
- Willey JS, Parker C, Valero V, Lim B, Reuben JM, Krishnamurthy S, Gong Y, Scoggins ME, Dryden MJ, Liu DD, Woodward WA, Ueno NT. Abstract OT1-02-01: A phase II study of anti-PD-1 (MK-3475) therapy in patients with metastatic inflammatory breast cancer (MIBC) or non-IBC triple negative breast cancer (non-IBC TNBC) who have achieved clinical response or stable disease to prior chemotherapy. Cancer Res 78(4_Suppl), 2018.
- Angela Alexander, Jie Willey, Huiming Sun, Charla A Parker, Angela N Marx, Anita L Wood, Sangeetha M Reddy, James M Reuben, Roland L Bassett, Huong T Le-Petross, Savitri Krishnamurthy, Yun Gong, Wendy A Woodward, Vicente Valero, Naoto T Ueno, Bora Lim. A single arm phase II study of adjuvant anti-PD1 (pembrolizumab) in combination with hormonal therapy in patients with hormone receptor (HR)-positive localized inflammatory breast cancer. Cancer Res 78(4 Suppl), 2018.
- Yam C, Santiago L, Candelaria RP, Adrada BE, Rauch GM, Hess KR, Litton JK, Piwnica-Worms H, Mittendorf EA, Ueno NT, Lim B, Murthy RK, Damodaran S, Helgason T, Huo L, Thompson AM, Gilcrease MZ, Symmans WF, Moulder SL, Yang W. Abstract P6-03-05: Risk of needle-track seeding with serial ultrasound guided biopsies in triple negative breast cancer. Cancer Res 78(4_Suppl), 2018.
- Willey JS, Marx AN, Lim B, Ibrahim NK, Valero V, Mittendorf EM, Reuben JM, Le-Petross HT, Whitman GJ, Krishnamurthy S, Woodward WA, Lucci A, Liu DD, Shen Y, Ueno NT. Abstract OT1-01-05: A phase II study using talimogene laherparepvec as a single agent for inflammatory breast cancer or non-inflammatory breast cancer patients with inoperable local recurrence. Cancer Res 78(4_Suppl), 2018.
- Willey JS, Parker C, Valero V, Lim B, Reuben JM, Krishnamurthy S, Gong Y, Scoggins ME, Dryden MJ, Liu DD, Woodward WW, Ueno NT. Abstract OT1-02-01: A phase II study of anti-PD-1 (MK-3475) therapy in patients with metastatic inflammatory breast cancer (MIBC) or non-IBC triple negative breast cancer (TNBC). Cancer Res 78(4_Suppl), 2018.
- Willey J, Parker C, Lim B, Valero V, Le-Petross HT, Krishnamurthy S, Woodward WA, Lucci A, Wood AL, Sun H, Babiera GV, Song J, Shen Y, Wang X, Ueno NT. Abstract OT3-06-04: A randomized phase II study of neoadjuvant panitumumab/carboplatin/paclitaxel (PaCT) versus carboplatin/paclitaxel (CT) followed by adriamycin and cyclophosphamide. Cancer Res 78(4_Suppl), 2018.
- Cohen EN, Jayachandran G, Gao H, Tin S, Alvarez RH, Valero V, Lim B, Ueno NT, Reuben J. Abstract P2-02-04: Circulating protein biomarker profile for inflammatory breast cancer using a multiplexed proximity extension assay. Cancer Res 78(4_Suppl), 2018.
- Alexander A, Willey J, Sun H, Parker CA, Marx AN, Wood AL, Reddy SM, Reuben RM, Bassett RL, Le-Petross CH, Krishnamurthy S, Gong Y, Woodward WA, Valero V, Ueno NT, Lim B. Abstract OT1-02-05: A single arm phase II study of adjuvant anti-PD1 (pembrolizumab) in combination with hormonal therapy in patients with hormone receptor (HR)-positive inflammatory breast cancer. Cancer Res 78(4_Suppl), 2018.
- Lee J, Lim B, Pearson T, Tripathy D, Ordentlich P, Ueno NT. Abstract P5-21-15: The synergistic antitumor activity of entinostat (MS-275) in combination with palbociclib (PD 0332991) in estrogen receptor-positive and triple-negative …. Cancer Res 78(4_Suppl), 2018.
- Yam C, Huo L, Hess KR, Litton JK, Yang W, Piwnica-Worms H, EA Mittendorf EA, NT Ueno NT, Lim B, Murthy RK, Damodaran S, Helgason T, Thompson AM, Santiago L, Candelaria RP, Rauch GM, Adrada BE, Symmans WF, Gilcrease MZ, Moulder SL. Abstract P1-07-22: Androgen receptor positivity is associated with nodal disease in triple negative breast cancer. Cancer Res 78(4_Suppl), 2018.
- Rauch GM, Li H, Zhu H, Adrada BE, Santiago L, Candelaria B, Wang H, Leung J, Thompson AM, Litton JK, Wu Y, Lim B, Moulder SL, Mittendorf EA, Yang W. Abstract P4-02-04: Quantitative MRI features analysis for differentiation of triple negative and HER2 positive subtypes of breast cancer. Cancer Res 78(4_Suppl), 2018.
- Espinosa-Fernandez JR, Eckhardt BL, Lee J, Seitz RS, Hout DR, Ring BZ, Lim B, Ueno NT. Abstract P5-06-04: Classification of molecular subtypes of triple-negative breast cancer cell lines using two models. Cancer Res 78(4_Suppl), 2018.
- Lim B, Lee J, Liu H, Pearson T, Coffer L, Tripathy D, Ueno NT. Preclinical evaluation of imipridone ONC201 in triple negative breast cancer identifies predictive biomarkers and combinatorial opportunities. Cancer Res 77(13 Suppl):4294, 2017.
- Meric-Bernstam F, Evans K, Zheng X, Su X, Yuca E, Scott S, Akcakanat A, Ueno NT, Lim B, Litton J, Valero V, Symmans WF, Hortobagyi G, Perou C, Tripathy D, Draetta G, Marszalek J, Gonzalez-Angulo AM, Moulder S. Oxidative phosphorylation as a target in triple negative breast cancer therapy. Cancer Res 77(13 Suppl):4970, 2017.
- Damodaran S, Hess K, Rauch M, Astrada B, Santiago L, Litton J, Mittendorf M, Lim B, Ueno NT, Tripathy D, Thompson A, Gilcrease M, Yang W, Piwnica-Worms H, Symmans WF, Moulder SL. Abstract CT062: NCT02456857: A phase II trial of liposomal doxorubicin, bevacizumab and everolimus (DAE) in patients with localized triple-negative breast cancer (TNBC) with tumors predicted insensitive to standard neoadjuvant chemotherapy. Cancer Res 77(13 Suppl):CT062, 2017.
- Ding Q, Chen H, Lim B, Damodaran S, Chen W, Tripathy D, Piha-Paul SA, Luthra R, Broaddus RR, Meric-Bernstam F, Sahin AA. HER2 Somatic Mutation Analysis in Breast Cancer: Correlation with Clinicopathologic Features. Laboratory Invest, 2017.
- Jayachandran G, Cohen EN, Gao H, Alvarez RH, Valero V, Lim B, Woodward WA, Ueno NT, Reuben JM. Abstract P1-02-07: Delineation of breast cancer based on circulating protein biomarker profile using the OLINK proteomics multiplexed proximity extension assay. Cancer Res 77(4 Suppl):P1-02-07, 2017.
- Moulder S, Hess K, Rauch M, Astrada B, Litton J, Mittendorf E, Ueno NT, Tripathy D, Lim B, Piwnica-Worms H, Thompson A, Symmans WF. Abstract OT2-01-22: NCT02456857: A phase II trial of liposomal doxorubicin, bevacizumab and everolimus (DAE) in patients (pts) with localized triple-negative breast cancer (TNBC) with tumors predicted insensitive to standard neoadjuvant chemotherapy (NACT). Cancer Res 77(4 Suppl):OT2-01-22, 2017.
- Fujii T, Lim B, Helgason T, Hess KR, Gilcrease MZ, Willey JS, Tripathy D, Litton JK, Moulder S, Krishnamurthy S, Yang W, Reuben JM, Symmans WF, Ueno NT. Abstract OT3-02-05: NCI-2016-00367: A phase IIB study of neoadjuvant ZT regimen (enzalutamide therapy in combination with weekly paclitaxel) for androgen receptor (AR)-positive triple-negative breast cancer (TNBC). Cancer Res 77(4 Suppl):OT3-02-05, 2017.
- Lim B, Helgason T, Hess KR, Piwnica-Worms H, Yang W, Adrada BE, Rauch GM, Gilcrease MZ, Symmans WF, Huo L, Mittendorf EA, Thompson A, Moulder S, Tripathy D, Ueno NT. Abstract OT2-01-20: Phase IIB study of neoadjuvant panitumumab combined with carboplatin and paclitaxel (PaCT) for anthracycline-resistant triple-negative breast cancer (TNBC). Cancer Res 77(4 Suppl):OT2-01-20, 2017.
- Harano K, Wang Y, Lim B, Seitz RS, Morris SW, Bailey DB, Hout DR, Skelton RL, Ring BZ, Masuda H, Rao AUK, Woodward WA, Reuben JM, Ueno NT. Rates of immune inflitration in patients with triple-negative breast cancers by molecular subtype and in patients with inflammatory and non-inflammatory breast cancers. Cancer Res 76(14_Suppl), 2016.
- Diamond JR, Borges VF, Kabos P, Krill-Jackson E, Graham R, Hoffman A, Lim B, Richards D, Salkeni MA, Wilks S, Patel C, Neuwirth R, Kneissi M, Zohren F. Phase 1b/2 safety and efficacy of TAK-228 (MLN0128), plus exemestane or fulvestrant in postmenopausal women with ER+/HER2- metastatic breast cancer. Ann Oncol 27(Suppl_6), 2016.
- Moulder SL, Litton JK, Mittendorf EA, Yang W, Ueno NT, Hess KR, Valero V, Murthy RK, Ibrahim N, Lim B, Arun B, Thompson AM, Piwnica-Worms H, Tripathy D, Symmans WF. Improving outcomes in triple-negative breast cancer (TNBC) using molecular characterization and diagnostic imaging to identify and treat chemo-insensitive disease. Ann Oncol 27(Suppl_6), 2016.
- Lim B, Murthy RK, Jackson S, Willey J, Lee J, Alvarez, RH, karuturi MS, Barcenas CH, Ibrahim NK, Booser DJ, Moulder SL, Giordano SH, Brewster AM, Walters RS, Brown PH, Tripathy D, Valero V, Ueno NT. Open-label phase Ib study of entinostat (E), and lapatinib (L) alone, and in combination with trastuzumab (T) in patients (pts) with HER2+ metastatic (mHER2+) breast cancer after progression on trastuzumab. J Clin Oncol 34(15_Suppl), 2016. e-Pub 2016.
- Fujii T, Kogawa T, Dong W, Litton JK, Moulder SL, Tripathy D, Hunt K, Iwamoto T, Pusztai L, Shen Y, Lim B, Ueno NT. New threshold of ER positivity in early-stage HER2-negative breast cancer. J Clin Oncol 34(15_Suppl), 2016. e-Pub 2016.
- Mitri Z, Ueno NT, Yang W, Valero V, Litton J, Murthy R, Lim B, Ibrahim NK, Arun BK, Mittendorf EA, Hunt KK, Meric-Bernstam F, Thompson A, Gilcrease M, Piwnica-Worms H, Tripathy D, Fraser WF, Moulder-Thompson S. Women's triple-negative, first-line treatment: Improving outcomes in triple-negative breast cancer using molecular triaging and diagnostic imaging to guide neoadjuvnat therapy. Cancer Res 76(4_Suppl), 2016. e-Pub 2016.
- Sato N, Wakabayashi M, Lee J, Lim B, Ueno NT, Ishihara H. Predicting the response of molecular targeting agents in triple-negative breast cancer cell lines by kinase activities. Cancer Res 76(4_Suppl), 2016.
- Fujii T, Wang Y, Reuben JM, Krupa R, Grat R, Dugan L, Kouw J, Marriucci D, Lim B, Barcenas CH, Marx AN, Tripathy D, Dittamore R, Ueno NT. Androgen receptor expression on circulating tumor cells in metastatic breast cancer. Cancer Res 76(14_Suppl). e-Pub 2016.
- Baumeister MD, Wagner J, Prabhu VV, Kline CL, Lim B, Allen JE, Dicker DT, El-Deiry WS. ONC201 induces cell death in triple negative, BRCA1 deficient and non-triple negative breast cancer cells. Cancer Res 76(14_Suppl). e-Pub 2016.
- Baumeister MD, Wagner J, Prabhu VV, Kline CL, Lim B, Allen JE, Dicker DT, El-Deiry WS. Novel small molecule ONC201 induces cell death and targets chemotherapy-resistant cancer stem-like cells in triple negative breast cancer. Cancer Res 76(14_Suppl). e-Pub 2016.
- Matsuda N, Wang X, Willey J, Parker CA, James M, Brewster A, James RM, Stauder MC, Woodward W, Lucci A, Babiera G, DeSnyder SM, Alvarez RH, Lim B, Valero V, Tripathy D, Ueno NT. Phase II study of panitumumab, nab-paclitaxel, and carboplatin followed by FEC neoadjuvant chemotherapy for patients with primary HER2-negative inflammatory breast cancer. J Clin Oncol 34(15_Suppl). e-Pub 2016.
- Fujii T, Wang Y, Rao A, Lim B, Ueno NT, Le-Petross CH. A Pilot Study: Radiogenomics of Inflammatory Breast Cancer. Cancer Res 76(14_Suppl), 2016.
- Torres-Adorno AM, Lee JJ, Kogawa T, Bartholomeusz C, Pitner MK, Ordentlich P, Lim B, Tripathy D, Ueno NT.. The histone deacetylase inhibitor entinostat enhances the efficacy of the MEK inhibitor pimasertib against aggressive types of breast cancer through Noxa-mediated myeloid cell leukemia 1 degradation. Cancer Res 75(9_Suppl), 2015.
- Yamauchi T, Imamura CK, Yamauchi H, Jinno H, Takahashi M, Kitagawa Y, Nakamura S, Lim B, Krishnamurthy S, Reuben JM, Liu D, Tripathy D, Zujewski JA, Chen H, Takebe N, Saya H, Ueno NT. CD44v as a potential predictive biomarker for pathologic complete response in primary HER2+ breast cancer: Utility of adaptive response biopsy in preoperative therapy. Cancer Res 75(9_Suppl), 2015.
- Lim B, Summer J, Alvarez R, Ibrahim N, Willey J, Murthy RK, Booser D, Giordano S, Barcenas C, Brewster A, Walters R, Brown PH, Tripathy D, Valero V, Ueno NT. A single-center, open-label phase 1b study of entinostat and lapatinib alone, and in combination with trastuzumab in patients with HER2+ metastatic breast cancer after progression on trastuzumab. Cancer Res 75(9_Suppl), 2015.
- French JT, Hess KR, Liu DD, Raghav KPS, Hortobagyi GN, Arun B, Valero V, Ueno NT, Alvarez RH, Woodward WA, Debeb BG, Moulder SL, Lim B, Tripathy D, Ibrahim NK. Development of CNS metastasis and subsequent survival in patients with inflammatory breast cancer. J Clin Oncol 33(15_Suppl), 2015.
- Matsuda N, Alvarez RH, Krishnamurthy S, Willey JS, Wang X, Lim B, Parker CA, Marx A, Babiera G, Booser DJ, Murray JL, Arun B, Brewster AM, Reuben JM, Woodward WA, Lucci A, Gainer SM, Tripathy D, Valero V, Ueno NT. Phase II study of panitumumab, nab-paclitaxel, and carboplatin followed by FEC neoadjuvant chemotherapy for patients with primary HER-2 negative inflammatory breast cancer. J Clin Oncol 33(15_Suppl), 2015.
- Fujii T, Kogawa T, Wei C, Fouad TM, Harano K, Park YS, Lim B, Tripathy D, Ueno NT, Litton JK. Association of body mass index with survival outcome in three breast cancer subtypes. J Clin Oncol 33(15_Suppl), 2015.
- Lim B, Dicker DT, Kline LC, El-Deiry WS. Exploring the best therapeutic partner of triple negative breast cancers: using different characteristics/dependent pathways of triple negative breast cancer cell lines based on subgroups. Cancer Res 73(24_Suppl), 2014.
- Matthew E, Zhou L, Lim B, Lamparella NE, Dicker DT, Gallant J-N, Joshi M, Holder SL, Harouaka R, Zheng S, Drabick JJ, Truica CI, Yang Z, El-Deiry WS. Immunophenotyping circulating tumor cells in patients with unknown primary. Cancer Res 73(24_Suppl), 2014.
- El-Deiry WS, Xiu J, Lim B, Scicchitano A, Feeley E, Harvey HA, Yee NS. Molecular Profiling of 6,892 Colorectal Cancer patients to identify potential treatment options. J Clin Oncol 32(15_Suppl), 2014.
- Lim B, Dolloff NG, Allen JE, Dicker DT, El-Deiry WS. Elucidating the Change of TRAIL Sensitivity in Basal-Like TNBC Cell Lines by Lapatinib, and Further Therapeutic Implications. Cancer Res 73(24_Suppl), 2013.
- LIm B, Dolloff NG, Allen JE, Dicker DT, El-Deiry WS. Lapatinib Restores TRAIL-Mediated Apoptosis in TRAIL-resistant TNBC through an off-target strategy-that Appears to be independent of increased Death Receptor expression. Cancer Res 73(8_Suppl), 2013.
- Lim B, Ali SM, Varlotto JM, Higgins K, DeCarmp MM, Recht A, Flickinger JC, Reed M, Toth J, Kelsey CR.. Does Anatomic Segmentectomy have Better Outcomes than Wedge Resections in Stage I NSCLC Patients Treated by Sub-Lobar Resection. J Clin Oncol 31(15_Suppl), 2013.
- Rhee SS, Lim B, Kim H, Wang Y, Aziz U, Butt U, Tang W, Vuchak LA, DeMichele A, Troxel AB, Feldman MD, Meinkoth JL, Brose MS. Rap1 GTPase Activating Protein (Rap1GAP) is Down-Regulated in DCIS and Invasive Ductal Carcinoma. Cancer Res 71(8_Suppl), 2011.
- Mintzer DM, Lim B, Sataloff DM; Pennsylvania Hospital, Philadelphia, PA. Breast cancer in the "very elderly": Staging, treatment, and outcomes in patients over age 80. J Clin Oncol 28(15_Suppl), 2010.
Book Chapters
- Le-Petross CH, Lim B, Hylton N. MRI and Neoadjuvant chemotherapy. In: Breast Oncology: Techniques, Indications, and Interpretation. Springer, 2016.
- Rizvi SM, Lim B. Current Treatment of Febrile Neutropenia: Tailored, Individual Based Therapy. In: iMOP. Springer International Publishing, 771-8, 2015.
Grant & Contract Support
Title: | Identify molecules that enhance anti-tumor activity of EP-100 in ER-positive, triple-negative and inflammatory breast cancer cells lines |
Funding Source: | Esperance |
Role: | Co-Principal Investigator |
Title: | A Preclinical and Clinical research Protocol of KAPT Project |
Funding Source: | Nittobo |
Role: | Co-Principal Investigator |
Title: | Determine in vitro and in vivo anti-tumor activity of Naclynamide (XBP1-inflammasome inhibitor) in inflammatory breast cancer |
Funding Source: | Therimeunex |
Role: | Co-Principal Investigator |
Title: | E6201: MEK Inhibitor - In vitro anti-tumor and in vivo anti-matastasis effect of E6201 in triple negative breast cancer |
Funding Source: | Strategia Therapeutics |
Role: | Co-Principal Investigator |
Title: | Determining the anti-tumor efficacy of DS-8201a based on novel HER2 targeted drug resistant HER2 positive breast cancer cell lines |
Funding Source: | Daiichi Sankyo |
Role: | Co-Investigator |
Title: | Identification of molecules that enhance anti-tumor activity of eribulin in metastatic breast cancer cell lines |
Funding Source: | Eisai |
Role: | Co-Investigator |
Title: | The therapeutic molecular targets that enhances anti-tumor activity of neratinib in breast cancer |
Funding Source: | Puma Biotechnology |
Role: | Co-Principal Investigator |
Title: | Enhancing anti-EGFR therapeutic efficacy in inflammatory breast cancer |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Human Cell Atlas Seed Network - Breast |
Funding Source: | Chan Zuckerberg Institute |
Role: | Co-Principal Investigator |
Title: | Single cell transcriptome of IBC cells and surrounding microenvironment |
Funding Source: | SWOG HOPE foundation |
Role: | Principal Investigator |
Title: | The Role of Lung Resident Mesenchymal Stem Cells in Post-Chemotherapy Lung Metastases of Breast Cancer |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Proteogenomic Analysis of Treatment Refractory Cancers |
Funding Source: | AbbVie Inc |
Role: | Principal Investigator |
Title: | BC200589P1 - Therapeutic Targeting of Nuclear Hormone Receptors in Neurofibromin/NF1-Depleted Breast Cancer |
Funding Source: | Department of Defense (DOD) |
Role: | Principal Investigator |
Title: | Selectively targeting myeloid derived suppressor cells (MDSCs) through TRAIL receptor 2 to enhance the efficacy of CAR T cell therapy for treatment of breast cancer |
Funding Source: | V Foundation |
Role: | Co-Investigator |
Title: | Optimizing Treatment for NF1-Deficient Metastatic ER+ Breast Cancers (Expansion Award) |
Funding Source: | Department of Defense (DOD) |
Role: | Partnering PI |
Title: | Proteomics and Metabolomics Core Facility |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | Co-Investigator |
Title: | Systematic Characterization of Small Nucleolar RNAs in Cancer |
Funding Source: | NIH/NCI |
Role: | Consortium PI |
Title: | Translational Research in Breast Cancer |
Funding Source: | NIH/NCI |
Role: | Core Principal Investigator |
Title: | Translational Research in Breast Cancer- Project 1 |
Funding Source: | NIH/NCI |
Role: | Core Principal Investigator |
Title: | The Role of Lung Resident Mesenchymal Stem Cells in Post-chemotherapy Lung Metastases of Breast Cancer |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Systematic Targeting Small Nucleolar RNA Augments Immunotherapeutic Efficacy |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Metabolic Adaptation in Triple Negative Breast Cancer Residual Disease Following Chemotherapy |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Rapid Response Monitoring with Circulating Tumor DNA in Metastatic Breast Cancer |
Funding Source: | NIH/NCI |
Role: | Co-Principal Investigator |
Title: | The role of HER2 activating mutations in ER+ breast cancer metastasis |
Funding Source: | American Cancer Society (ACS) |
Role: | Co-Investigator |
Title: | Mechanisms of tumor cell clustering in breast cancer metastasis |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Minority PDX Development and Trial Center: Baylor College of Medicine and MD Anderson Cancer Center Collaboration in Mechanistic Studies to Dissect and Combat Health Disparities in Cancer |
Funding Source: | NIH/NCI |
Role: | Project 2 Leader |
Title: | Human Breast Cell Atlas Seed Network |
Funding Source: | Chan Zuckerberg Foundation |
Role: | Co-Principal Investigator |
Title: | Circulating Tumor DNA Based-Monitoring in Early Stage and Advanced Breast Cancer |
Funding Source: | BCRF |
Role: | Co-Investigator |
Title: | Identification of Therapeutic molecular targets that enhance anti-tumor activity of neratinib in breast cancer |
Funding Source: | PUMA Biotechnology, Inc. |
Role: | Principal Investigator |
Title: | A phase Ib/II study of safety and efficacy of MLN0128 (Dual TORC 1/2 Inhibitor) in combination with exemestane or fulvestrant therapy in postmenopausal women with ER+/HER2-advanced or metastatic breast cancer that has progressed on treatment with everolimus in combination with exemestane or fulvestrant |
Funding Source: | Millenium Pharmaceuticals |
Role: | Principal Investigator |
Title: | A preclinical and clinical research protocol of KAPt project |
Funding Source: | Nittobo Medical Co LTD |
Role: | Principal Investigator |
Title: | A phase II study of anti-PD-1 (pembrolizumab) in combination with hormonal therapy in patients with hormone receptor (HR)-positive localized inflammatory breast cancer (IBC) who did not achieve a pathological complete response (pCR) to neoadjuvant chemotherapy |
Funding Source: | Merck |
Role: | Principal Investigator |
Title: | A Phase II Trial of Panitumumab, Carboplatin and Paclitaxel (PaCT) in Patients with Localized Triple-Negative Breast Cancer (TNBC) with Tumors Predicted Insensitive to Standard Neoadjuvant Chemotherapy |
Funding Source: | Amgen |
Role: | Principal Investigator |
Title: | A Phase II Clinical Trial of Pembrolizumab (MK-3475) as Monotherapy for Metastatic Triple-Negative Breast Cancer (nIBC) (KEYNOTE-086) |
Funding Source: | Merck |
Role: | Principal Investigator |
Title: | A Phase II study of triple combination of atezolizumab, cobimetinib, eribulin (ACE) in patients with chemo resistant IBC |
Funding Source: | Genetech |
Role: | Principal Investigator |
Title: | A phase 1b study of neratinib, pertuzumab and trastuzumab with taxol (3HT) in metastatic and locally advanced breast cancer, and phase II study of 3HT followed by AC in HER2 + primary IBC, and neratinib with taxol (NT) followed by AC in HR+ /HER2- primary IBC |
Funding Source: | PUMA Biotech |
Role: | Principal Investigator |
Title: | Determine in vitro and in vivo anti-tumor activity of naclynamide in inflammatory breast cancer Time |
Funding Source: | Therimunex |
Role: | Co-Principal Investigator |
Title: | Delineating the Evolution of Multi-Organ Metastasis in Breast Cancer with Single Cell Genomics Time |
Funding Source: | Emerson Collective |
Role: | Co-Investigator |
Title: | A phase I study of OTS167PO, a MELK inhibitor, to evaluate safety, tolerability and pharmacokinetics in patients with advanced breast cancer and dose-expansion study in patients with triple negative breast cancer and dose-expansion |
Funding Source: | Oncotherapy |
Role: | Co-Principal Investigator |
Title: | Enhancing anti-EGFR Therapeutic Efficacy in Inflammatory Breast Cancer |
Funding Source: | NIH/NCI |
Role: | Co-Principal Investigator |
Title: | A phase IIB study of neoadjuvant ZT regimen (enzalutamide therapy in combination with weekly paclitaxel) for androgen receptor (AR)-positive triple- negative breast cancer |
Funding Source: | Astellas Pharma Global |
Role: | Principal Investigator |
Title: | Identification of molecules that enhance anti-tumor activity of eribulin in metastatic breast cancer cell lines |
Funding Source: | EISAI, Inc |
Role: | Co-Principal Investigator |
Title: | A Multi-ctr, Ph 2 study of the Glutaminase inhibitor CB-839 in combination with Paclitaxel in patients with advanced TNBC including patients of african ancestry and non-african ancestry (CX-839-007) |
Funding Source: | Calithera |
Role: | Principal Investigator |
Title: | Determining the anti-tumor efficacy of DS-8201a or patritumab based on novel HER2 targeted drug resistant HER2 positive breast cancer cell lines |
Funding Source: | Daiichi Sankyo |
Role: | Co-Investigator |
Title: | Study 2: Identify molecules that enhance anti-tumor activity of EP-100 in ER- positive, triple-negative and inflammatory breast cancer cells lines |
Funding Source: | Esperance Pharmaceuticals |
Role: | Co-Principal Investigator |
Title: | Single cell transcriptome of IBC cells and surrounding microenvironment |
Funding Source: | SWOG Hope Foundation ITSC |
Role: | Principal Investigator |
Title: | Human Cell ATLAS project – breast |
Funding Source: | Silicon Valley Community Foundation |
Role: | Co-Principal Investigator |
Title: | In vitro anti-tumor and in vivo anti-metastatic effect of E6201 |
Funding Source: | Strategia Therapeutics |
Role: | Co-Principal Investigator |
Title: | A Phase II Study of BIBF 1120 (Nintedanib) for Patients with HER2 Normal Metastatic Inflammatory Breast Cancer (IBC) |
Funding Source: | Boehringer Ingleheim |
Role: | Co-Principal Investigator |
Title: | Determination of the anti-tumor and anti-metastatic effect of OR-S2, a EXH1/2 dual inhibitor, in metastatic breast cancer |
Funding Source: | Daiichi Sankyo |
Role: | Co-Principal Investigator |
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CV information above last modified May 03, 2024