Daoyan Wei, PhD
Department of Gastroenterology Hepatology and Nutrition, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Gastroenterology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2000 | Shanghai Jiaotong University, P.R, CHN, PHD, Molecular Biology & Biochemistry |
Experience & Service
Academic Appointments
Assistant Professor, Department of Gastroenterology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2020
Assistant Professor, Department of Gastrointestinal (GI) Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2013
Instructor, Department of Gastrointestinal (GI) Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2004 - 2010
Selected Publications
Peer-Reviewed Articles
- Chakraborty S, Wei D, Tran M, Lang FF, Newman RA, Yang P. PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death. Neoplasia 54:101008, 2024. e-Pub 2024. PMID: 38823209.
- Zuo X, Wang L, Liu Y, Wang H, Hafley M, Gagea M, Chen R, Xiong Y, Pan S, Shureiqi I, Bresalier RS, Wei D. Dysregulated KLF4 expression plays a pivotal role in the pathogenesis of pancreatic intraductal papillary mucinous neoplasms. Gut. e-Pub 2024. PMID: 38969489.
- Wei D, Wang L, Zuo X, Maitra A, Bresalier RS. A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer. Clin Cancer Res 30(4):655-662, 2024. PMID: 37831007.
- Liu Y, Wei D, Deguchi Y, Xu W, Tian R, Liu F, Xu M, Mao F, Li D, Chen W, Valentin LA, Deguchi E, Yao JC, Shureiqi I, Zuo X. PPARδ dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment. Gastric Cancer 26(6):904-917, 2023. e-Pub 2023. PMID: 37572185.
- Wei D, Wang L, Liu Y, Hafley MA, Tan L, Lorenzi PL, Yang P, Zuo X, Bresalier RS. Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression. Dig Dis Sci 68(7):3043-3058, 2023. e-Pub 2023. PMID: 37071246.
- Wei D, Chen D, Mou H, Chakraborty S, Wei B, Tan L, Lorenzi PL, Qian X, Yang P. Targeting Glutamine Metabolism with a Novel Na+/K+-ATPase Inhibitor RX108 in Hepatocellular Carcinoma. Mol Cancer Ther 22(6):693-705, 2023. PMID: 36780187.
- Liu Y, Deguchi Y, Wei D, Liu F, Moussalli MJ, Deguchi E, Li D, Wang H, Valentin LA, Colby JK, Wang J, Zheng X, Ying H, Gagea M, Ji B, Shi J, Yao JC, Zuo X, Shureiqi I. Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. Nat Commun 13(1):2665, 2022. e-Pub 2022. PMID: 35562376.
- Wei D, Wang L, Zuo X, Bresalier RS. Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer. Cancers (Basel) 13(11), 2021. e-Pub 2021. PMID: 34072725.
- Al-Hassan JM, Wei D, Chakraborty S, Conway T, Rhea P, Wei B, Tran M, Gagea M, Afzal M, Oommen S, Nair D, Paul BM, Yang P. Fraction B From Catfish Epidermal Secretions Kills Pancreatic Cancer Cells, Inhibits CD44 Expression and Stemness, and Alters Cancer Cell Metabolism. Front Pharmacol 12:659590, 2021. e-Pub 2021. PMID: 34349642.
- Wang L, Jia Z, Xie D, Zhao T, Tan Z, Zhang S, Kong F, Wei D, Xie K. Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics. Cancer Res 80(20):4500-4513, 2020. e-Pub 2020. PMID: 32699135.
- Liu F, Zuo X, Liu Y, Deguchi Y, Moussalli MJ, Chen W, Yang P, Wei B, Tan L, Lorenzi PL, Gao S, Jaoude JC, Mehdizadeh A, Valentin LA, Wei D, Shureiqi I. Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P. Cell Rep 32(7):108049, 2020. PMID: 32814052.
- Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I. PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice. Gastroenterology 157(1):163-178, 2019. e-Pub 2019. PMID: 30885780.
- Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, Xu W, Xu M, Liu F, Gao S, Jaoude JC, Chrieki SP, Moussalli MJ, Gagea M, Morris J, Broaddus RR, Zuo X, Shureiqi I. Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. Cancer Res 79(5):954-969, 2019. e-Pub 2019. PMID: 30679176.
- Wang L, Shen F, Stroehlein JR, Wei D. Context-dependent functions of KLF4 in cancers: could alternative splicing isoforms be the key?. Cancer Letters 438:10-16, 2018. e-Pub 2018. PMID: 30217565.
- Xie VK, Li Z, Yan Y, Jia Z, Zuo X, Ju Z, Wang J, Du J, Xie D, Xie K, Wei D. DNA-methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-like factor 4 Expression. Clin Cancer Res 23(18):5585-5597, 2017. e-Pub 2017. PMID: 28659310.
- Guo K, Cui J, Quan M, Xie D, Jia Z, Wei D, Wang L, Gao Y, Ma Q, Xie K. The Novel KLF4/MSI2 Signaling Pathway Regulates Growth and Metastasis of Pancreatic Cancer. Clin Cancer Res 23(3):687-696, 2017. e-Pub 2016. PMID: 27449499.
- Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, Wei D, Hung MC, Sood AK, Shureiqi I. Metastasis regulation by PPARD expression in cancer cells. JCI Insight 2(1):e91419, 2017. e-Pub 2017. PMID: 28097239.
- Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell 29(3):324-338, 2016. PMID: 26977883.
- Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K. KLF4-mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. Cancer Res. e-Pub 2016. PMID: 26880805.
- Sun H, Tang H, Xie D, Jia Z, Ma Z, Wei D, Mishra L, Gao Y, Zheng S, Xie K, Peng Z. Krüppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6. Clin Cancer Res 22(2):502-12, 2016. e-Pub 2015. PMID: 26338995.
- Quan M, Cui J, Xia T, Jia Z, Xie D, Wei D, Huang S, Huang Q, Zheng S, Xie K. Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling. Cancer Res 75(22):4778-89, 2015. e-Pub 2015. PMID: 26483206.
- Yan Y, Zuo X, Wei D. Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target. Stem Cells Transl Med 4(9):1033-43, 2015. e-Pub 2015. PMID: 26136504.
- Li Z, Jia Z, Gao Y, Xie D, Wei D, Cui J, Mishra L, Huang S, Zhang Y, Xie K. Activation of vitamin D receptor signaling downregulates the expression of nuclear FOXM1 protein and suppresses pancreatic cancer cell stemness. Clin Cancer Res 21(4):844-53, 2015. e-Pub 2014. PMID: 25501129.
- Li L, Li Z, Kong X, Xie D, Jia Z, Jiang W, Cui J, Du Y, Wei D, Huang S, Xie K. Down-Regulation of MicroRNA 494 via Loss of SMAD4 Increases FOXM1 and β-Catenin. Gastroenterology 147(2):485-97.e18, 2014. e-Pub 2014. PMID: 24859161.
- Shi M, Cui J, Du J, Wei D, Jia Z, Zhang J, Zhu Z, Gao Y, Xie K. A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res 20(16):4370-80, 2014. e-Pub 2014. PMID: 24947925.
- Cui J, Shi M, Xie D, Wei D, Jia Z, Zheng S, Gao Y, Huang S, Xie K. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clin Cancer Res 20(10):2595-606, 2014. e-Pub 2014. PMID: 24634381.
- Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology 143(3):799-810.e1-2, 2012. e-Pub 2012. PMID: 22677193.
- Li Q, Jia Z, Wang L, Kong X, Li Q, Guo K, Tan D, Le X, Wei D, Huang S, Mishra L, Xie K. Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology 142(3):531-542, 2012. PMID: 22155367.
- Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S, Xie K. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Research 72(3):655-665, 2012. PMID: 22194465.
- Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Suyun H, Huang S, Wang L, Xie K.. Combining betulinic acid and mithramycin A effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res 71(15):5182-93, 2011. e-Pub 2011. PMID: 21673052.
- Wei D, Wang L, Kanai M, Jia Z, Le X, Li Q, Wang H, Xie K. KLF4a Up-regulation Promotes Cell Cycle Progression and Reduces Survival Time of Patients with Pancreatic Cancer. Gastroenterology 139(6):2135-45, 2010. e-Pub 2010. PMID: 20727893.
- Jia Z, Gao Y, Wang L, Li Q, Zhang J, Le X, Wei D, Yao JC, Chang DZ, Huang S, Xie K. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res 70(3):1111-9, 2010. e-Pub 2010. PMID: 20086170.
- Li Q, Wei D, Wang L, Wang L, Jia Z, Le X, Gao Y, Huang S, Xie K. Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse. Clin Exp Metastasis 27(1):11-8, 2010. e-Pub 2009. PMID: 19882218.
- Wei D, Kanai M, Jia Z, Le X, Xie K. Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res 68(12):4631-9, 2008. PMID: 18559508.
- Kanai M, Wei D, Li Q, Jia Z, Ajani J, Le X, Yao J, Xie K. Loss of Kruppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression. Clin Cancer Res 12(21):6395-402, 2006. PMID: 17085651.
- Wei D, Kanai M, Huang S, Xie K. Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis 27(1):23-31, 2006. e-Pub 2005. PMID: 16219632.
- Wei D, Gong W, Oh SC, Li Q, Kim WD, Wang L, Le X, Yao J, Wu TT, Huang S, Xie K. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Res 65(11):4809-16, 2005. PMID: 15930301.
- Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT, Huang S, Xie K. Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res 65(7):2746-54, 2005.
- Wei D, Gong W, Oh SC, Li Q, Kim WD, Wang L, Le X, Yao J, Wu TT, Huang S, Xie K. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Res 102(24):8758-63, 2005.
- Wei D, Wang L, He Y, Xiong HQ, Abbruzzese JL, Xie K. Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Cancer Res 64(6):2030-2038, 2004. PMID: 15026340.
- Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22(3):319-329, 2003. PMID: 12545153.
- Wei D, Richardson EL, Zhu K, Wang L, Le X, He Y, Huang S, Xie K. Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase. Cancer Res 63(14):3855-3859, 2003. PMID: 12873972.
- Yang S, Wei D, Wang D, Phimphilai M, Kerbsbach P, Francesch R. In vitro and in vivo synergetic interaction between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein 2 in stimulating osteoblast differentiation. Journal of Bone and Mineral Research 18(4):705-715, 2003.
Invited Articles
- Liu Y, Colby JK, Zuo X, Jaoude J, Wei D, Shureiqi I. The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. Int J Mol Sci 19(11), 2018. e-Pub 2018. PMID: 30373124.
Editorials
- Wang L, Shureiqi I, Stroehlein JR, Wei D. Novel and emerging innate immune therapeutic targets for pancreatic cancer. Expert Opin Ther Targets 22(12):977-981, 2018. PMID: 30332892.
Grant & Contract Support
| Title: | Genetic alterations of KLF4 in human pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | KLF4 Genetic and Epigenetic Changes in Human Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Genetic approaches to pancreatic cancer progression |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Dietary DIM in pancreatic cancer prevention and therapy |
| Funding Source: | American Institute for Cancer Research (AICR) |
| Role: | Principal Investigator |
| Title: | The role of KLF4a in pancreatic cancer |
| Funding Source: | American Association for Cancer Research (AACR) |
| Role: | Principal Investigator |
| Title: | Molecular mechanisms of pancreatic cancer pathogenesis |
| Funding Source: | MD Anderson Institutional Research Grant |
| Role: | Principal Investigator |
| Title: | Molecular Mediators of Pancreatic Cancer Invasion and Progression |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | The role of KLF4 in pancreatic injury and regeneration |
| Funding Source: | The Texas Medical Center Digestive Diseases Center |
| Role: | Principal Investigator |
| Title: | Functional validation of pancreatic cancer progression biomarkers |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Molecular mechanisms of pancreatic cancer initiation |
| Funding Source: | MD Anderson Cancer Center Institutional Research Grant |
| Role: | Principal Investigator |
| Title: | Development of novel liquid biopsy for early detection and risk prediction of pancreatic neoplasms |
| Funding Source: | Elsa U Pardee Foundation |
| Role: | Principal Investigator |
| Title: | Integrated signaling in pancreatic cancer progression |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Clinical Significance of Pancreatic Cancer Differentiation and Dedifferentiation |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Novel biomarkers for early detection and intervention of pancreatic neoplasms |
| Funding Source: | Duncan Family Institute Foundation |
| Role: | Principal Investigator |
| Title: | Unveiling mechanisms underlying therapeutic resistance of pancreatic cancer |
| Funding Source: | IRG Grant |
| Role: | Principal Investigator |
| Title: | Dissecting and targeting tumor-stroma interactions in pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
Patient Reviews
CV information above last modified October 30, 2024