David R. Grosshans, M.D., Ph.D.

Peer-Reviewed Articles

1. Wefel JS, Deshmukh S, Brown PD, Grosshans DR, Sulman EP, Cerhan JH, Mehta MP, Khuntia D, Shi W, Mishra MV, Suh JH, Laack NN, Chen Y, Curtis AA, Laba JM, Elsayed A, Thakrar A, Pugh SL, Bruner DW. Impact of Apolipoprotein E (APOE) Genotype on Neurocognitive Function (NCF) in Patients with Brain Metastasis (BM): An Analysis of NRG Oncology's RTOG 0614. Int J Radiat Oncol Biol Phys 119(3):846-857, 2024. e-Pub 2023. PMID: 38101486.
2. Chen M, Yang D, Zhu XR, Ma L, Grosshans DR, Shao Y, Lu W. Investigation of intra-fractionated range guided adaptive proton therapy (RGAPT): (Part II) range-shift compensated on-line treatment adaptation and verification. Phys Med Biol 69(15), 2024. e-Pub 2024. PMID: 38861995.
3. Yang D, Zhu XR, Chen M, Ma L, Cheng X, Grosshans DR, Lu W, Shao Y. Investigation of intra-fractionated range guided adaptive proton therapy: (Part I) on-line PET imaging and range measurement. Phys Med Biol 69(15), 2024. e-Pub 2024. PMID: 38861997.
4. Milgrom SA, van Luijk P, Pino R, Ronckers CM, Kremer LC, Gidley PW, Grosshans DR, Laskar S, Okcu MF, Constine LS, Paulino AC. Salivary and Dental Complications in Childhood Cancer Survivors Treated With Radiation Therapy to the Head and Neck: A Pediatric Normal Tissue Effects in the Clinic (PENTEC) Comprehensive Review. Int J Radiat Oncol Biol Phys 119(2):467-481, 2024. e-Pub 2021. PMID: 34074567.
5. Beckham TH, Rooney MK, McAleer MF, Ghia AJ, Tom MC, Perni S, McGovern SL, Grosshans DR, Chung C, Wang C, De B, Swanson T, Paulino A, Jiang W, Ferguson S, Patel CB, Li J, Yeboa DN. Hypofractionated radiotherapy for glioblastoma: A large institutional retrospective assessment of 2 approaches. Neurooncol Pract 11(3):266-274, 2024. e-Pub 2024. PMID: 38737610.
6. Kim M, Maldonado JA, Pandey P, El Alam MB, Kouzy R, Christopherson K, Minsky BD, Nugyen QN, Grosshans DR, Lin LL, Mitchell MP, Klopp AH, Lee PP, Bird J, Satcher R, Lewis VO, Lin PP, Tang C, Koong AC, Moon B, Colbert LE. Single-fraction radiation retreatment for bone metastases: role of a rapid access clinic. BMJ Support Palliat Care. e-Pub 2024. PMID: 38843933.
7. Abu-Arja MH, Brown AL, Su JM, Okcu MF, Lindsay HB, McGovern SL, McAleer MF, Grosshans DR, Chintagumpala MM, Paulino AC. The cochlear dose and the age at radiotherapy predict severe hearing loss after passive scattering proton therapy and cisplatin in children with medulloblastoma. Neuro Oncol. e-Pub 2024. PMID: 38916058.
8. Sienna J, Kahalley LS, Mabbott D, Grosshans DR, Santiago AT, Paulino ADC, Merchant TE, Manzar GS, Dama H, Hodgson DC, Chintagumpala M, Okcu MF, Whitehead WE, Laperriere N, Ramaswamy V, Bartels U, Tabori U, Bennett JM, Das A, Craig T, Tsang DS. Proton Therapy Mediates Dose Reductions to Brain Structures Associated with Cognition in Children with Medulloblastoma. Int J Radiat Oncol Biol Phys 119(1):200-207, 2024. e-Pub 2023. PMID: 38040059.
9. Wang C, Rooney MK, Alvarez-Breckenridge C, Beckham TH, Chung C, De BS, Ghia AJ, Grosshans DR, Majd NK, McAleer MF, McGovern SL, North RY, Paulino AC, Perni S, Reddy JP, Rhines LD, Swanson TA, Tatsui CE, Tom MC, Yeboa DN, Li J. Outcomes and Pattern of Care for Spinal Myxopapillary Ependymoma in the Modern Era-A Population-Based Observational Study. Cancers (Basel) 16(11), 2024. e-Pub 2024. PMID: 38893133.
10. Bronk JK, McAleer MF, McGovern SL, Lassen-Ramshad Y, Safwat A, Daw NC, Rainusso N, Mahajan A, Grosshans DR, Paulino AC. Comprehensive radiotherapy for pediatric Ewing Sarcoma: Outcomes of a prospective proton study. Radiother Oncol 195:110270. e-Pub 2024. PMID: 38583721.
11. Grosshans DR, Thomas R, Zhang D, Cronkite C, Thomas R, Singh S, Bronk L, Morales R, Duman J. Subcellular functions of tau mediates repair response and synaptic homeostasis in injury. Res Sq, 2024. e-Pub 2024. PMID: 38464175.
12. Goudarzi HM, Lim G, Grosshans DR, Mohan R, Cao W. Incorporating variable RBE in IMPT optimization for ependymoma. J Appl Clin Med Phys 25(1):e14207, 2024. e-Pub 2023. PMID: 37985962.
13. Durante M, Bender T, Schickel E, Mayer M, Debus J, Grosshans DR, Schroeder I. Aberrant choroid plexus formation in human cerebral organoids exposed to radiation. Res Sq, 2023. e-Pub 2023. PMID: 37886443.
14. Cao W, Li Y, Zhang X, Poenisch F, Yepes P, Sahoo N, Grosshans DR, McGovern SL, Gunn GB, Frank SJ, Zhu XR. Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma. J Appl Clin Med Phys 24(7):e13954, 2023. e-Pub 2023. PMID: 36913484.
15. Matsui JK, Allen PK, Perlow HK, Johnson JM, Paulino AC, McAleer MF, Fouladi M, Grosshans DR, Ghia AJ, Li J, Zaky WT, Chintagumpala MM, Palmer JD, McGovern SL. Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience. J Neurooncol 163(3):717-726, 2023. e-Pub 2023. PMID: 37440097.
16. Mash LE, Kahalley LS, Raghubar KP, Goodrich-Hunsaker NJ, Abildskov TJ, De Leon LA, MacLeod M, Stancel H, Parsons K, Biekman B, Desai NK, Grosshans DR, Paulino AC, Chu ZD, Whitehead WE, Okcu MF, Chintagumpala M, Wilde EA. Cognitive Sparing in Proton versus Photon Radiotherapy for Pediatric Brain Tumor Is Associated with White Matter Integrity: An Exploratory Study. Cancers (Basel) 15(6), 2023. e-Pub 2023. PMID: 36980730.
17. Hoffman LM, Jaimes C, Mankad K, Mirsky DM, Tamrazi B, Tinkle CL, Kline C, Ramasubramanian A, Malbari F, Mangum R, Lindsay H, Horne V, Daniels DJ, Keole S, Grosshans DR, Young Poussaint T, Packer R, Cavalheiro S, Bison B, Hankinson TC, Müller HL, Bartels U, Warren KE, Chintagumpala M. Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Neuro Oncol 25(2):224-233, 2023. e-Pub 2022. PMID: 36124689.
18. Mash LE, Kahalley LS, Okcu MF, Grosshans DR, Paulino AC, Stancel H, De Leon L, Wilde E, Desai N, Chu ZD, Whitehead WE, Chintagumpala M, Raghubar KP. Superior verbal learning and memory in pediatric brain tumor survivors treated with proton versus photon radiotherapy. Neuropsychology 37(2):204-217, 2023. e-Pub 2022. PMID: 36480379.
19. De B, Florez MA, Ludmir EB, Maor MH, McGovern SL, McAleer MF, Grosshans DR, Chang EL, Mahajan A, Paulino AC. Late Effects of Craniospinal Irradiation Using Electron Spinal Fields for Pediatric Cancer Patients. Int J Radiat Oncol Biol Phys 115(1):164-173, 2023. e-Pub 2022. PMID: 35716848.
20. Chevli N, Grosshans DR, McAleer MF, Foster JH, Harrison D, McGovern SL, Paulino AC. Renal function in abdominal neuroblastoma patients undergoing proton radiotherapy. Pediatric Blood & Cancer 70(1):e29981, 2023. e-Pub 2022. PMID: 36129239.
21. McGovern SL, Luo D, Johnson J, Nguyen K, Li J, McAleer MF, Yeboa D, Grosshans DR, Ghia AJ, Chung C, Bishop AJ, Song J, Thall PF, Brown PD, Mahajan A. A Prospective Study of Conventionally Fractionated Dose Constraints for Re-Irradiation of Primary Brain Tumors in Adults. Pract Radiat Oncol 13(3):231-238, 2023. e-Pub 2022. PMID: 36596356.
22. Guan F, Zhao L, Bronk JK, Maletic-Savatic M, Grosshans DR, Carlson DJ. Editorial: Advances in the biological effects of ionizing radiation. Front Oncol 13:1352771, 2023. e-Pub 2024. PMID: 38234403.
23. Gandy K, Chambers T, Raghubar KP, Fatih Okcu M, Chintagumpala M, Taylor O, Mahajan A, Kahalley LS, Chan W, Grosshans DR, Brown AL, Douglas Ris M. A Prospective Evaluation of Fatigue in Pediatric Brain Tumor Patients Treated With Radiation Therapy. J Pediatr Hematol Oncol Nurs 39(6):358-365, 2022. e-Pub 2022. PMID: 36285825.
24. Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, Bronk L, Cao X, Chatterjee A, Clay DE, Courtney C, Fox DT, Gaber MW, Gerecht S, Grabham P, Grosshans DR, Guan F, Jezuit EA, Kirsch DG, Liu Z, Maletic-Savatic M, Miller KM, Montague RA, Nagpal P, Osenberg S, Parkitny L, Pierce NA, Porada C, Rosenberg SM, Sargunas P, Sharma S, Spangler J, Tavakol DN, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young DW, Donoviel D. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst) 35:105-112, 2022. e-Pub 2022. PMID: 36336356.
25. McNerlin C, Guan F, Bronk L, Lei K, Grosshans DR, Young DW, Gaber MW, Maletic-Savatic M. Targeting hippocampal neurogenesis to protect astronauts' cognition and mood from decline due to space radiation effects. Life Sci Space Res (Amst) 35:170-179, 2022. e-Pub 2022. PMID: 36336363.
26. Kirkman MA, Day J, Gehring K, Zienius K, Grosshans DR, Taphoorn M, Li J, Brown PD. Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation. Cochrane Database Syst Rev 11(11):CD011335, 2022. e-Pub 2022. PMID: 36427235.
27. Bishop AJ, Amini B, Lin H, Raza SM, Patel S, Grosshans DR, Ghia A, Farooqi A, Guadagnolo BA, Mitra D, Akdemir KC, Lazar AJ, Wang WL, Alvarez-Breckenridge C, Bird J, Rhines LD, Somaiah N, Conley AP. Immune Checkpoint Inhibitors Have Clinical Activity in Patients With Recurrent Chordoma. J Immunother 45(8):374-378, 2022. e-Pub 2022. PMID: 35943386.
28. Mallick S, V R A, Giridhar P, Upadhyay R, Kim BK, Sharma A, Elghazawy H, Elumalai T, Solipuram V, Hsieh CE, Hentz C, Solanki AA, Li J, Chan DP, Ness E, Venkatesulu BP, Grosshans DR. A Systematic Review and Meta-analysis of the Impact of Radiation-Related Lymphopenia on Outcomes in High-Grade Gliomas. South Asian J Cancer 11(4):361-369, 2022. e-Pub 2022. PMID: 36756098.
29. Upadhyay R, Liao K, Grosshans DR, McGovern SL, Frances McAleer M, Zaky W, Chintagumpala MM, Mahajan A, Nana Yeboa D, Paulino AC. Quantifying the risk and dosimetric variables of symptomatic brainstem injury after proton beam radiation in pediatric brain tumors. Neuro Oncol 24(9):1571-1581, 2022. e-Pub 2022. PMID: 35157767.
30. McCurdy MD, Raghubar KP, Christopher K, Okcu MF, Wilde E, Desai N, Chu ZD, Gragert M, Stancel H, Warren EH, Whitehead WE, Grosshans DR, Paulino AC, Chintagumpala M, Kahalley LS. Predicting neurocognitive function in pediatric brain tumor early survivorship: The neurological predictor scale and the incremental validity of tumor size. Pediatr Blood Cancer 69(9):e29803, 2022. e-Pub 2022. PMID: 35709014.
31. Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: helium ion therapy. Phys Med Biol 67(15), 2022. e-Pub 2022. PMID: 35395649.
32. Warren EAH, Raghubar KP, Cirino PT, Child AE, Lupo PJ, Grosshans DR, Paulino AC, Okcu MF, Minard CG, Ris MD, Mahajan A, Viana A, Chintagumpala M, Kahalley LS. Cognitive predictors of social adjustment in pediatric brain tumor survivors treated with photon versus proton radiation therapy. Pediatr Blood Cancer 69(6):e29645, 2022. e-Pub 2022. PMID: 35285129.
33. Tang TT, Zawaski JA, Kesler S, Beamish CA, Inoue T, Perez EC, Bronk L, Poenisch F, Briere TM, Sabek OM, Grosshans DR, Waleed Gaber M. Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model. Int J Radiat Oncol Biol Phys 112(2):554-564, 2022. e-Pub 2021. PMID: 34509550.
34. Bronk JK, Amer A, Khose S, Flint D, Adair A, Yepes P, Grosshans DR, Johnson J, Chung C. Brain Radiation Necrosis Outside the Target Volume After Proton Radiation Therapy: Analyses of Multiparametric Imaging and Proton Biologic Effectiveness. Adv Radiat Oncol 7(6):101044, 2022. e-Pub 2022. PMID: 36420203.
35. Brown PD, Chung C, Liu DD, McAvoy S, Grosshans DR, Al Feghali K, Mahajan A, Li J, McGovern SL, McAleer MF, Ghia AJ, Sulman EP, Penas-Prado M, de Groot JF, Heimberger AB, Wang J, Armstrong TS, Gilbert MR, Guha-Thakurta N, Wefel JS. A Prospective Phase II Randomized Trial of Proton Radiotherapy vs. Intensity Modulated Radiotherapy for Patients with Newly Diagnosed Glioblastoma. Neuro Oncol 23(8):1337-1347, 2021. e-Pub 2021. PMID: 33647972.
36. Heitzer AM, Kahalley LS, Minard CG, Stafford C, Grosshans DR, Okcu MF, Raghubar KP, Gragert M, McCurdy M, Warren EH, Gomez J, Ris MD, Paulino AC, Chintagumpala M. Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas. Pediatr Blood Cancer 68(8):e29096, 2021. e-Pub 2021. PMID: 34019329.
37. Paulino AC, Ludmir EB, Grosshans DR, Su JM, McGovern SL, Okcu MF, McAleer MF, Baxter PA, Mahajan A, Chintagumpala MM. Overall survival and secondary malignant neoplasms in children receiving passively scattered proton or photon craniospinal irradiation for medulloblastoma. Cancer. e-Pub 2021. PMID: 34254296.
38. Flint DB, Bright SJ, McFadden CH, Konishi T, Ohsawa D, Turner B, Lin SH, Grosshans DR, Chiu HS, Sumazin P, Shaitelman SF, Sawakuchi GO. Cell lines of the same anatomic site and histologic type show large variability in intrinsic radiosensitivity and relative biological effectiveness to protons and carbon ions. Med Phys 48(6):3243-3261, 2021. e-Pub 2021. PMID: 33837540.
39. Oyefiade A, Paltin I, De Luca CR, Hardy KK, Grosshans DR, Chintagumpala M, Mabbott DJ, Kahalley LS. Cognitive Risk in Survivors of Pediatric Brain Tumors. J Clin Oncol 39(16):1718-1726, 2021. e-Pub 2021. PMID: 33886348.
40. Child AE, Warren EA, Grosshans DR, Paulino AC, Okcu MF, Ris MD, Mahajan A, Orobio J, Cirino PT, Minard CG, Viana AG, Bick J, Woods SP, Chintagumpala M, Kahalley LS. Long-term cognitive and academic outcomes among pediatric brain tumor survivors treated with proton versus photon radiotherapy. Pediatr Blood Cancer:e29125. e-Pub 2021. PMID: 34114294.
41. Skaarup M, Lundemann MJ, Darkner S, Jørgensen M, Marner L, Mirkovic D, Grosshans DR, Peeler C, Mohan R, Vogelius IR, Appelt A. A framework for voxel-based assessment of biological effect after proton radiotherapy in pediatric brain cancer patients using multi-modal imaging. Med Phys. e-Pub 2021. PMID: 34021597.
42. Beamish CA, Zawaski JA, Inoue T, Sarkar P, Grosshans DR, Sabek OM, Gaber MW. NF-κB Blockade by NEMO Binding Domain Peptide Ameliorates Inflammation and Neurobehavioral Sequelae After Cranial Radiation Therapy in Juvenile Mice. Int J Radiat Oncol Biol Phys 109(5):1508-1520, 2021. e-Pub 2020. PMID: 33307152.
43. Hanania AN, Paulino AC, Ludmir EB, Shah VS, Su JM, McGovern SL, Baxter PA, McAleer MF, Grosshans DR, Okcu MF, Chintagumpala MM. Early Radiotherapy Preserves Vision in Sporadic Optic Pathway Glioma. Cancer. e-Pub 2021. PMID: 33739455.
44. Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC. Disease Control and Patterns of Failure After Proton Beam Therapy for Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 109(3):718-725, 2021. PMID: 33516439.
45. Bishop AJ, Livingston JA, Ning MS, Valdez ID, Wages CA, McAleer MF, Paulino AC, Grosshans DR, Woodhouse KD, Tao R, Roth ME, Gunn GB, McGovern SL. Young Adult Populations Face yet another Barrier to Care with Insurers: Limited Access to Proton Therapy. Int J Radiat Oncol Biol Phys. e-Pub 2021. PMID: 33677051.
46. Nantavithya C, Paulino AC, Liao K, Woodhouse KD, McGovern SL, Grosshans DR, McAleer MF, Khatua S, Chintagumpala MM, Majd N, Zaky W, Yeboa DN. Observed-to-expected incidence ratios of second malignant neoplasms after radiation therapy for medulloblastoma: A surveillance, epidemiology, and end results analysis. Cancer. e-Pub 2021. PMID: 33721338.
47. Liu SM, Brooks ED, Rubin ML, MD Anderson Cancer Center Radiation Oncology Fellows Consortium, Grosshans DR, Frank SJ, McAleer MF, McGovern SL, Paulino AC, Woodhouse KD. Referral Patterns and Treatment Delays in Medulloblastoma: A Large Academic Proton Center Experience. Int J Part Ther 7(3):1-10, 2021. e-Pub 2020. PMID: 33604411.
48. Spiotto MT, McGovern SL, Gunn GB, Grosshans DR, McAleer MF, Frank SJ, Paulino AC. Proton Radiotherapy to Reduce Late Complications in Childhood Head and Neck Cancers. Int J Part Ther 8(1):155-167, 2021. e-Pub 2021. PMID: 34285943.
49. Al Feghali KA, Randall JW, Liu DD, Wefel JS, Brown PD, Grosshans DR, McAvoy SA, Farhat MA, Li J, McGovern SL, McAleer MF, Ghia AJ, Paulino AC, Sulman EP, Penas-Prado M, Wang J, de Groot J, Heimberger AB, Armstrong TS, Gilbert MR, Mahajan A, Guha-Thakurta N, Chung C. Phase II trial of proton therapy versus photon IMRT for GBM: secondary analysis comparison of progression-free survival between RANO versus clinical assessment. Neurooncol Adv 3(1):vdab073, 2021. e-Pub 2021. PMID: 34337411.
50. Abolfath R, Grosshans DR, Mohan R. Oxygen depletion in FLASH ultra-high-dose-rate radiotherapy: A molecular dynamics simulation. Med Phys 47(12):6551-6561, 2020. e-Pub 2020. PMID: 33089504.
51. Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jäkel O, Mohan R, Titt U, Grosshans DR. Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques. Cancers (Basel) 12(12), 2020. e-Pub 2020. PMID: 33291477.
52. Paganetti H, Beltran CJ, Both S, Dong L, Flanz JB, Furutani KM, Grassberger C, Grosshans DR, Knopf AC, Langendijk JA, Nyström H, Parodi K, Raaymakers BW, Richter C, Sawakuchi GO, Schippers JM, Shaitelman SF, Teo K, Unkelbach J, Wohlfahrt P, Lomax AJ. Roadmap: proton therapy physics and biology. Phys Med Biol. e-Pub 2020. PMID: 33227715.
53. Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Author Correction: Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Sci Rep 10(1):19101, 2020. e-Pub 2020. PMID: 33127998.
54. Lin TA, Ludmir EB, Liao KP, McAleer MF, Bishop AJ, Grosshans DR, McGovern S, Woodhouse KD, Paulino AC, Yeboa DN. Relationship between treatment center case volume and survival for localized Ewing sarcoma: The role of radiotherapy timing. Pediatr Blood Cancer:e28685. e-Pub 2020. PMID: 32881378.
55. Nantavithya C, Paulino AC, Liao K, McGovern SL, Grosshans DR, McAleer MF, Woodhouse KD, Khatua S, Chintagumpala MM, Majd NK, Yeboa DN. Development of second primary tumors and outcomes in medulloblastoma by treatment modality: A Surveillance, Epidemiology, and End Results analysis. Pediatr Blood Cancer 67(8):e28373, 2020. e-Pub 2020. PMID: 32453481.
56. Vassiliev ON, Peterson CB, Grosshans DR, Mohan R. A simple model for calculating relative biological effectiveness of X-rays and gamma radiation in cell survival. Br J Radiol 93(1112):20190949, 2020. e-Pub 2020. PMID: 32464080.
57. Mohan R, Liu AY, Brown PD, Mahajan A, Dinh J, Chung C, McAvoy S, McAleer MF, Lin SH, Li J, Ghia AJ, Zhu C, Sulman EP, de Groot JF, Heimberger AB, McGovern SL, Grassberger C, Shih H, Ellsworth S, Grosshans DR. Proton Therapy Reduces the Likelihood of High-Grade Radiation-Induced Lymphopenia in Glioblastoma Patients: Phase II Randomized Study of Protons vs. Photons. Neuro Oncol. e-Pub 2020. PMID: 32750703.
58. Abolfath R, Helo Y, Carlson DJ, Stewart R, Grosshans DR, Mohan R. A New Approach to Modeling the Microdosimetry of Proton Therapy Beams. Med Phys 47(7):3184-3190, 2020. e-Pub 2020. PMID: 32249429.
59. Kahalley LS, Peterson R, Ris MD, Janzen L, Okcu MF, Grosshans DR, Ramaswamy V, Paulino AC, Hodgson D, Mahajan A, Tsang DS, Laperriere N, Whitehead WE, Dauser RC, Taylor MD, Bouffet E, Chintagumpala M, Mabbott D. Reply to S.A. Milgrom et al. J Clin Oncol 38(19):2212-2213, 2020. e-Pub 2020. PMID: 32374644.
60. Noticewala SS, Ludmir EB, Bishop AJ, Chung C, Ghia AJ, Grosshans DR, McGovern S, Paulino AC, Wang C, Woodhouse KD, Yeboa DN, Prabhu SS, Weathers SP, Das P, Koong AC, McAleer MF, Li J. Radiation for Glioblastoma in the Era of Coronavirus Disease 2019 (COVID-19): Patient Selection and Hypofractionation to Maximize Benefit and Minimize Risk. Adv Radiat Oncol 5(4):743-745, 2020. e-Pub 2020. PMID: 32775785.
61. Bai X, Lim G, Grosshans DR, Mohan R, Cao W. A biological effect-guided optimization approach using beam distal-edge avoidance for intensity-modulated proton therapy. Med Phys. e-Pub 2020. PMID: 32557747.
62. Zhang D, Zhou W, Lam TT, Li V, Duman JG, Dougherty PM, Grosshans DR. Cranial irradiation induces axon initial segment dysfunction and neuronal injury in the prefrontal cortex and impairs hippocampal coupling. Neurooncol Adv. e-Pub 2020. PMID: 32642710.
63. Raghubar KP, Rothhaar MC, Yeates KO, Mahone EM, Grosshans DR, Scheurer ME, Ris MD. Premorbid functioning as a predictor of outcome in pediatric brain tumor: An initial examination of the normalcy assumption. Pediatr Blood Cancer 67(4):e28135, 2020. e-Pub 2019. PMID: 31886612.
64. Brown PD, Gondi V, Pugh S, Tome WA, Wefel JS, Armstrong TS, Bovi JA, Robinson C, Konski A, Khuntia D, Grosshans DR, Benzinger TLS, Bruner D, Gilbert MR, Roberge D, Kundapur V, Devisetty K, Shah S, Usuki K, Anderson BM, Stea B, Yoon H, Li J, Laack NN, Kruser TJ, Chmura SJ, Shi W, Deshmukh S, Mehta MP, Kachnic LA, for NRG Oncology. Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001. J Clin Oncol 38(10):1019-1029, 2020. e-Pub 2020. PMID: 32058845.
65. Roth AK, Ris MD, Orobio J, Xue J, Mahajan A, Paulino AC, Grosshans DR, Okcu MF, Chintagumpala M, Kahalley LS. Cognitive mediators of adaptive functioning outcomes in survivors of pediatric brain tumors treated with proton radiotherapy. Pediatr Blood Cancer 67(2):e28064, 2020. e-Pub 2019. PMID: 31736188.
66. Kahalley LS, Peterson R, Ris MD, Janzen L, Okcu MF, Grosshans DR, Ramaswamy V, Paulino AC, Hodgson D, Mahajan A, Tsang DS, Laperriere N, Whitehead WE, Dauser RC, Taylor MD, Conklin HM, Chintagumpala M, Bouffet E, Mabbott D. Superior Intellectual Outcomes After Proton Radiotherapy Compared With Photon Radiotherapy for Pediatric Medulloblastoma. J Clin Oncol 38(5):454-461, 2020. e-Pub 2019. PMID: 31774710.
67. Evans LT, DeMonte F, Grosshans DR, Ghia AJ, Habib A, Raza SM. Salvage Therapy for Local Progression following Definitive Therapy for Skull Base Chordomas: Is There a Role of Stereotactic Radiosurgery?. J Neurol Surg B Skull Base 81(1):97-106, 2020. e-Pub 2019. PMID: 32021756.
68. Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Sci Rep 10(1):3199, 2020. e-Pub 2020. PMID: 32081928.
69. Abolfath R, Peeler C, Mirkovic D, Mohan R, Grosshans DR. A DNA damage multi-scale model for NTCP in proton and hadron therapy. Med Phys 47(4). e-Pub 2020. PMID: 31955444.
70. Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO. Non-homologous end joining is more important than proton linear energy transfer in dictating cell death. Int J Radiat Oncol Biol Phys 105(5):1119-1125, 2019. e-Pub 2019. PMID: 31425731.
71. Wu RY, Liu AY, Yang J, Williamson TD, Wisdom PG, Bronk L, Gao S, Grosshans DR, Fuller DC, Gunn GB, Zhu XR, Frank SJ. Evaluation of the accuracy of deformable image registration on MRI with a physical phantom. J Appl Clin Med Phys. e-Pub 2019. PMID: 31808307.
72. Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC. Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma. Pediatr Blood Cancer 66(11):e27952, 2019. e-Pub 2019. PMID: 31397065.
73. Vassiliev ON, Peterson CB, Cao W, Grosshans DR, Mohan R. Systematic microdosimetric data for protons of therapeutic energies calculated with Geant4-DNA. Phys Med Biol 64(21), 2019. e-Pub 2019. PMID: 31553958.
74. Raghubar KP, Orobio J, Ris MD, Heitzer AM, Roth A, Brown AL, Okcu MF, Chintagumpala M, Grosshans DR, Paulino AC, Mahajan A, Kahalley LS. Adaptive functioning in pediatric brain tumor survivors: An examination of ethnicity and socioeconomic status. Pediatr Blood Cancer 66(9):e27800, 2019. e-Pub 2019. PMID: 31134755.
75. Bagley AF, Grosshans DR, Philip NV, Foster J, McAleer MF, McGovern SL, Lassen-Ramshad Y, Mahajan A, Paulino AC. Efficacy of proton therapy in children with high-risk and locally recurrent neuroblastoma. Pediatr Blood Cancer 66(8):e27786, 2019. e-Pub 2019. PMID: 31050179.
76. Ludmir EB, Mahajan A, Ahern V, Ajithkumar T, Alapetite C, Bernier-Chastagner V, Bindra RS, Bishop AJ, Bolle S, Brown PD, Carrie C, Chalmers AJ, Chang EL, Chung C, Dieckmann K, Esiashvili N, Gandola L, Ghia AJ, Gondi V, Grosshans DR, Harrabi SB, Horan G, Indelicato DJ, Jalali R, Janssens GO, Krause M, Laack NN, Laperriere N, Laprie A, Li J, Marcus KJ, McGovern SL, Merchant TE, Merrell KW, Padovani L, Parkes J, Paulino AC, Schwarz R, Shih HA, Souhami L, Sulman EP, Taylor RE, Thorp N, Timmermann B, Wheeler G, Wolden SL, Woodhouse KD, Yeboa DN, Yock TI, Kortmann RD, McAleer MF. Assembling the brain trust: the multidisciplinary imperative in neuro-oncology. Nat Rev Clin Oncol 16(8):521-522, 2019. e-Pub 2019. PMID: 31150024.
77. Darne CD, Alsanea F, Robertson D, Guan F, Pan T, Grosshans DR, Beddar S. A novel proton imaging system using a large-volume liquid scintillator: a preliminary study. Medical Physics, 2019. PMID: 32194988.
78. Ning MS, Gomez DR, Shah AK, Kim CR, Palmer MB, Thaker NG, Grosshans DR, Liao Z, Chapman BV, Brooks ED, Tang C, Rosenthal DI, Garden AS, Frank SJ, Gunn GB. The Insurance Approval Process for Proton Radiation Therapy: A Significant Barrier to Patient Care. Int J Radiat Oncol Biol Phys 104(4):724-733, 2019. e-Pub 2018. PMID: 30557675.
79. Darne CD; Alsanea F; Robertson D; Guan F; Pan T; Grosshans DR; Beddar S. A proton imaging system using a volumetric liquid scintillator: a preliminary study. Biomedical Physics & Engineering Express 5(4), 2019. e-Pub 2019. PMID: 32194988.
80. Tang TT, Zawaski JA, Kesler SR, Beamish CA, Reddick WE, Glass JO, Carney DH, Sabek OM, Grosshans DR, Gaber MW. A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury. Neurooncol Adv. e-Pub 2019. PMID: 31608330.
81. Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness. Int J Radiat Oncol Biol Phys 104(2):316-324, 2019. e-Pub 2019. PMID: 30731186.
82. Kahalley LS, Ris MD, Mahajan A, Okcu MF, Chintagumpala M, Paulino AC, Whitehead WE, Minard CG, Stancel HH, Orobio J, Xue JJ, Warren EA, Grosshans DR. Prospective, Longitudinal Comparison of Neurocognitive Change in Pediatric Brain Tumor Patients Treated with Proton Radiotherapy versus Surgery Only. Neuro Oncol 21(6):809-818, 2019. e-Pub 2019. PMID: 30753584.
83. Amsbaugh MJ, Mahajan A, Thall PF, McAleer MF, Paulino AC, Grosshans DR, Khatua S, Ketonen L, Fontanilla H, McGovern SL. In Reply to Krishnatry and Manjali. Int J Radiat Oncol Biol Phys 104(2):468-469, 2019. PMID: 31047634.
84. Lin TA, Ludmir EB, Liao KP, McAleer MF, Grosshans DR, McGovern SL, Bishop AJ, Woodhouse KD, Paulino AC, Yeboa DN. Timing of Local Therapy Impacts Survival in Ewing Sarcoma. Int J Radiat Oncol Biol Phys 104(1):127-136, 2019. e-Pub 2018. PMID: 30593906.
85. Amsbaugh MJ, Mahajan A, Thall PF, McAleer MF, Paulino AC, Grosshans DR, Khatua S, Ketonen L, Fontanilla H, McGovern SL. A Phase I/II Trial of Reirradiation for Diffuse Intrinsic Pontine Glioma. Int J Radiat Oncol Biol Phys 104(1):144-148, 2019. e-Pub 2019. PMID: 30610915.
86. Ludmir EB, Mahajan A, Paulino AC, Jones JY, Ketonen LM, Su JM, Grosshans DR, McAleer MF, McGovern SL, Lassen-Ramshad YA, Adesina AM, Dauser RC, Weinberg JS, Chintagumpala MM. Increased Risk of Pseudoprogression among Pediatric Low-Grade Glioma Patients Treated with Proton versus Photon Radiotherapy. Neuro Oncol 21(5):686-695, 2019. e-Pub 2019. PMID: 30753704.
87. Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC. Patterns of failure following proton beam therapy for head and neck rhabdomyosarcoma. Radiother Oncol 134:143-150, 2019. e-Pub 2019. PMID: 31005208.
88. Buszek SM, Ikner S, Wiedermann L, Wang J, McAleer MF, Grosshans DR, de la Cruz Paulino A, McGovern SL, Chung C. Safety and Feasibility of Magnetic Resonance Imaging Simulation for Radiation Treatment Planning in Pediatric Patients: A Single Institution Experience. Advances in Radiation Oncology 4(2):362-366, 2019. e-Pub 2018. PMID: 31011682.
89. Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans DR, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H. Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Med Phys 46(3):e53-e78, 2019. e-Pub 2019. PMID: 30661238.
90. Abolfath R, Helo Y, Bronk L, Carabe A, Grosshans DR, Mohan R. Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control. The European Physical Journal D 73(64), 2019.
91. Durante M, Paganetti H, Pompos A, Kry SF, Wu X, Grosshans DR. Report of a National Cancer Institute Special Panel: Characterization of the Physical Parameters of Particle Beams for Biological Research. Medical Physics 46(2):e37-e52, 2019. e-Pub 2018. PMID: 30506898.
92. Jaramillo S, Grosshans DR, Philip N, Varan A, Akyüz C, McAleer MF, Mahajan A, McGovern SL. Radiation for ETMR: Literature review and case series of patients treated with proton therapy. Clin Transl Radiat Oncol 15:31-37, 2019. e-Pub 2018. PMID: 30582019.
93. Yeboa DN, Yu JB, Liao E, Huse J, Penas-Prado M, Kann BH, Sulman E, Grosshans DR, Contessa J. Differences in patterns of care and outcomes between grade II and grade III molecularly defined 1p19q co-deleted gliomas. Clin Transl Radiat Oncol 15:46-52, 2019. e-Pub 2018. PMID: 30656222.
94. Kohno R, Cao W, Yepes P, Bai X, Poenisch F, Grosshans DR, Akimoto T, Mohan R. Biological Dose Comparison between a Fixed RBE and a variable RBE in SFO and MFO IMPT with Various Multi-Beams for Brain Cancer. International Journal of Medical Physics,Clinical Engineering and Radiation Oncology 8(1):32-45, 2019.
95. Cao W, Khabazian A, Yepes P, Lim G, Poenisch F, Grosshans DR, Mohan R. Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'. Phys Med Biol 64(5):058002, 2019. e-Pub 2019. PMID: 30811349.
96. Bai X, Lim G, Grosshans D, Mohan R, Cao W.. Robust optimization to reduce the impact of biological effect variation from physical uncertainties in intensity-modulated proton therapy. Phys Med Biol 64(2):1361-1365, 2019. PMID: 30523932.
97. Guan F, Geng C, Carlson DJ, Ma DH, Bronk L, Gates D, Wang X, Kry SF, Grosshans DR, Mohan R. A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies. Phys Med Biol 64(1):015008, 2018. e-Pub 2018. PMID: 30523805.
98. Yepes P, Adair A, Frank SJ, Grosshans DR, Liao Z, Liu A, Mirkovic D, Poenisch F, Titt U, Wang Q, Mohan R. Fixed- versus Variable-RBE Computations for Intensity Modulated Proton Therapy. Adv Radiat Oncol 4(1):156-167, 2018. PMID: 30706024.
99. Yepes P, Adair A, Frank SJ, Grosshans DR, Liao Z, Liu A, Mirkovic D, Poenisch F, Titt U, Wang Q, Mohan R.. Fixed- versus Variable-RBE Computations for Intensity Modulated Proton Therapy. Adv Radiat Oncol 4(1):156-167, 2018.
100. Ludmir EB, Grosshans DR, Woodhouse KD. Radiotherapy Advances in Pediatric Neuro-Oncology. Bioengineering (Basel) 5(4), 2018. e-Pub 2018. PMID: 30400370.
101. Vatner RE, Niemierko A, Misra M, Weyman EA, Goebel CP, Ebb DH, Jones RM, Huang MS, Mahajan A, Grosshans DR, Paulino AC, Stanley T, MacDonald SM, Tarbell NJ, Yock TI. Endocrine Deficiency as a Function of Radiation Dose to the Hypothalamus and Pituitary in Pediatric and Young Adult Patients With Brain Tumors. J Clin Oncol 36(28):2854-2862, 2018. e-Pub 2018. PMID: 30118397.
102. Stoker J, Vora S, Patel A, Grosshans DR, Brown PD, Vern-Gross T, Bues M, Daniels T, Allred B, Uejo A, Kosiorek H, Bruso M, Keole S. Advantages of intensity modulated proton therapy during hippocampal. Physics and Imaging in Radiation Oncology 8(2018):28-32, 2018.
103. Raghubar KP, Lamba M, Cecil KM, Yeates KO, Mahone EM, Limke C, Grosshans DR, Beckwith TJ, Ris MD. Dose-volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study. Pediatr Blood Cancer 65(9):e27245, 2018. e-Pub 2018. PMID: 29856521.
104. Grosshans DR, Duman JG, Gaber MW, Sawakuchi G. Particle Radiation Induced Neurotoxicity in the Central Nervous System. International Journal of Particle Therapy, 2018.
105. Guan F, Geng C, Ma D, Bronk L, Kerr M, Li Y, Gates D, Kroger B, Sahoo N, Titt U, Grosshans DR, Mohan R. RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies. International Journal of Particle Therapy 5(1):160-171, 2018. PMID: 30338268.
106. Raza SM, Bell D, Freeman JL, Grosshans DR, Fuller GN, DeMonte F. Multimodality Management of Recurrent Skull Base Chordomas: Factors Impacting Tumor Control and Disease-Specific Survival. Oper Neurosurg (Hagerstown) 15(2):131-143, 2018. e-Pub 2017. PMID: 29040778.
107. Zhang D, Zhou W, Lam TT, Weng C, Bronk L, Ma D, Wang Q, Duman JG, Dougherty PM, Grosshans DR. Radiation induces age-dependent deficits in cortical synaptic plasticity. Neuro Oncol 20(9):1207-1214, 2018. e-Pub 2018. PMID: 29660023.
108. Paulino AC, Mahajan A, Ye R, Grosshans DR, Fatih Okcu M, Su J, McAleer MF, McGovern S, Mangona VA, Chintagumpala M. Ototoxicity and cochlear sparing in children with medulloblastoma: Proton vs. photon radiotherapy. Radiother Oncol 128(1):128-132, 2018. e-Pub 2018. PMID: 29373195.
109. Grosshans DR, Brown PD. Chemotherapy Plus Proton or Photon Radiation on a Trial. Int J Radiat Oncol Biol Phys 101(3):518-519, 2018. PMID: 29893270.
110. Willers H, Allen A, Grosshans DR, McMahon SJ, von Neubeck C, Wiese C, Vikram B. Toward A variable RBE for proton beam therapy. Radiother Oncol 128(1):68-75, 2018. e-Pub 2018. PMID: 29910006.
111. Ludmir EB, Paulino AC, Grosshans DR, McAleer MF, McGovern SL, Huh WW, Okcu MF, Harrell LM, Mahajan A. Regional Nodal Control for Head and Neck Alveolar Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 101(1):169-176, 2018. e-Pub 2018. PMID: 29477293.
112. Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, Kalapurakal J, Terezakis S, Kooy H, Grosshans DR, Makrigiorgos M, Mishra K, Poussaint TY, Cohen K, Fitzgerald T, Gondi V, Liu A, Michalski J, Mirkovic D, Mohan R, Perkins S, Wong K, Vikram B, Buchsbaum J, Kun L. National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. Int J Radiat Oncol Biol Phys 101(1):152-168, 2018. PMID: 29619963.
113. Wilke C, Grosshans DR, Duman J, Brown P, Li J. Radiation-induced cognitive toxicity: Pathophysiology and interventions to reduce toxicity in adults. Neuro Oncol 20(5):597-607, 2018. e-Pub 2017. PMID: 29045710.
114. Duman JG, Dinh J, Zhou W, Cham H, Mavratsas VC, Paveškovic M, Mulherkar S, McGovern SL, Tolias KF, Grosshans DR. Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses. Neuro Oncol 20(5):655-665, 2018. e-Pub 2017. PMID: 29112734.
115. Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans DR, Mohan R, Titt U. Erratum: "Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code" [Med. Phys. 42 (11), page range 6234-6247(2015)]. Med Phys 45(3):1302, 2018. e-Pub 2018. PMID: 29527697.
116. Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Erratum: "Monte Carlo simulations of3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness" [Med. Phys. 43 (2), page range 761-776(2016)]. Med Phys 45(3):1301, 2018. e-Pub 2018. PMID: 29527699.
117. Vassiliev ON, Kry SF, Grosshans DR, Mohan R. Average stopping powers for electron and photon sources for radiobiological modeling and microdosimetric applications. Phys Med Biol 63(5):055007, 2018. e-Pub 2018. PMID: 29411712.
118. Mohan R, Held KD, Story MD, Grosshans DR, Capala J. Proceedings of the National Cancer Institute Workshop on Charged Particle Radiobiology. Int J Radiat Oncol Biol Phys 100(4):816-831, 2018. e-Pub 2017. PMID: 29485053.
119. Yepes P, Adair A, Grosshans DR, Mirkovic D, Poenisch F, Titt U, Wang Q, Mohan R. Comparison of Monte Carlo and analytical dose computations for intensity modulated proton therapy. Phys Med Biol 63(4):045003, 2018. e-Pub 2018. PMID: 29339570.
120. Bronk JK, Guha-Thakurta N, Allen PK, Mahajan A, Grosshans DR, McGovern SL. Analysis of pseudoprogression after proton or photon therapy of 99 patients with low grade and anaplastic glioma. Clin Transl Radiat Oncol 9:30-34, 2018. PMID: 29594248.
121. Cao W, Khabazian A, Yepes PP, Lim GJ, Poenisch F, Grosshans DR, Mohan R. Linear energy transfer incorporated intensity modulated proton therapy optimization. Phys Med Biol 63(1), 2017. e-Pub 2017. PMID: 29131808.
122. Wang X, Li Y, Zhang X, Li H, Miyazaki K, Fujimoto R, Akiyama H, Gillin MT, Poenisch F, Sahoo N, Grosshans DR, Gunn B, Frank SJ, Wang P, Lang J, Hou Q, Zhu XR. Synchrotron-Based Pencil Beam Scanning Nozzle with an Integrated Mini-Ridge Filter: A Dosimetric Study to Optimize Treatment Delivery. Cancers (Basel) 9(12), 2017. e-Pub 2017. PMID: 29236051.
123. Mohan R, Peeler CR, Guan F, Bronk L, Cao W, Grosshans DR. Radiobiological issues in proton therapy. Acta Oncol 56(11):1-7, 2017. e-Pub 2017. PMID: 28826292.
124. Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmüller C, Jäkel O, Grosshans DR, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Med Phys 44(11):6061-6073, 2017. e-Pub 2017. PMID: 28880368.
125. Kohno R, Cao W, Yepes P, Bai X, Poenisch F, Grosshans DR, Akimoto T, Mohan R. Dose Comparison between Eclipse Dose Calculation and Fast Dose Calculator in Single- and Multi-Field Optimization Intensity-Modulated Proton Therapy Plans with Various Multi-Beams for Brain Cancer. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology. e-Pub 2017.
126. Patel D, Bronk L, Guan F, Peeler C, Brons S, Dokic I, Abdollahi A, Rittmueller C, Jäkel O, Grosshans DR, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Medical Physics 44(11):6061-6073, 2017. PMID: 28880368.
127. Vassiliev ON, Grosshans DR, Mohan R. A new formalism for modelling parameters α and β of the linear quadratic model of cell survival for hadron therapy. Phys Med Biol 62(20):8041-8059, 2017. e-Pub 2017. PMID: 28832343.
128. Raza SM, Gidley PW, Meis JM, Grosshans DR, Bell D, DeMonte F. Multimodality Treatment of Skull Base Chondrosarcomas: The Role of Histology Specific Treatment Protocols. Neurosurgery 81(3):520-530, 2017. PMID: 28368506.
129. Abolfath R, Peeler CR, Newpower M, Bronk L, Grosshans DR, Mohan R. A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data. Sci Rep 7(1):8340, 2017. e-Pub 2017. PMID: 28827691.
130. Antonini TN, Ris MD, Grosshans DR, Mahajan A, Okcu MF, Chintagumpala M, Paulino A, Child AE, Orobio J, Stancel HH, Kahalley LS. Attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy. Radiother Oncol 124(1):89-97, 2017. e-Pub 2017. PMID: 28655455.
131. Grosshans DR, Mohan R, Gondi V, Shih HA, Mahajan A, Brown PD. The role of image-guided intensity modulated proton therapy in glioma. Neuro Oncol 19(suppl_2):ii30-ii37, 2017. PMID: 28380636.
132. Hou P, Zhu KH, Park PC, Li H, Mahajan A, Grosshans DR. Proton Therapy for Juvenile Pilocytic Astrocytoma: Quantifying Treatment Responses by Magnetic Resonance Diffusion Tensor Imaging. International Journal of Particle Therapy 3(3):414-420, 2017.
133. Chun SG, Solberg TD, Grosshans DR, Nguyen QN, Simone CB, Mohan R, Liao Z, Hahn SM, Herman JM, Frank SJ. The Potential of Heavy-Ion Therapy to Improve Outcomes for Locally Advanced Non-Small Cell Lung Cancer. Front Oncol 7:201, 2017. e-Pub 2017. PMID: 28929085.
134. Peeler CR, Mirkovic D, Titt U, Blanchard P, Gunther JR, Mahajan A, Mohan R, Grosshans DR. Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma. Radiother Oncol 121(3):395-401, 2016. e-Pub 2016. PMID: 27863964.
135. Mohan R, Grosshans DR. Proton therapy - Present and future. Adv Drug Deliv Rev. e-Pub 2016. PMID: 27919760.
136. Wang X, Poenisch F, Sahoo N, Zhu RX, Lii M, Gillin MT, Li J, Grosshans DR. Spot scanning proton therapy minimizes neutron dose in the setting of radiation therapy administered during pregnancy. J Appl Clin Med Phys 17(5):366-376, 2016. e-Pub 2016. PMID: 27685136.
137. Jiang S, Wang J, Li H, Liao L, Li Y, Wang X, Yang Y, Zhu RX, Sahoo N, Gillin MT, Hojo Y, Sun J, Chang JY, Liao Z, Grosshans DR, Frank SJ, Zhang X. Novel Hybrid Scattering- and Scanning-Beam Proton Therapy Approach. International Journal of Particle Therapy 3(1):37-50, 2016.
138. Tucker SL, Liu A, Gomez D, Tang LL, Allen P, Yang J, Liao Z, Grosshans DR. Impact of heart and lung dose on early survival in patients with non-small cell lung cancer treated with chemoradiation. Radiother Oncol 119(3):495-500, 2016. e-Pub 2016. PMID: 27189523.
139. Owusu-Agyemang P, Popovich SM, Zavala AM, Grosshans DR, Van Meter A, Williams UU, Holmes AA, Arunkumar R, Rebello E, McAleer MF, Porche V, Mahajan A. A multi-institutional pilot survey of anesthesia practices during proton radiation therapy. Pract Radiat Oncol 6(3):155-9, 2016. e-Pub 2015. PMID: 26725965.
140. Agarwal A, Thaker NG, Tawk B, Allen PK, Grosshans DR, Herzog CE, Gombos DS, Mahajan A. The Evolution of Radiation Therapy for Retinoblastoma: The MD Anderson Cancer Center Experience. International Journal of Particle Therapy 4(4):490-498, 2016.
141. Kahalley LS, Ris MD, Grosshans DR, Okcu MF, Paulino AC, Chintagumpala M, Moore BD, Guffey D, Minard CG, Stancel HH, Mahajan A. Comparing Intelligence Quotient Change After Treatment With Proton Versus Photon Radiation Therapy for Pediatric Brain Tumors. J Clin Oncol 34(10):1043-9, 2016. e-Pub 2016. PMID: 26811522.
142. Grosshans DR. Proton therapy for paediatric medulloblastoma. Lancet Oncol 17(3):258-9, 2016. e-Pub 2016. PMID: 26830376.
143. Munck Af Rosenschold P, Engelholm SA, Brodin PN, Jørgensen M, Grosshans DR, Zhu RX, Palmer M, Crawford CN, Mahajan A. A Retrospective Evaluation of the Benefit of Referring Pediatric Cancer Patients to an External Proton Therapy Center. Pediatr Blood Cancer 63(2):262-269, 2016. e-Pub 2015. PMID: 26397177.
144. Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of ³He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Med Phys 43(2):761-76, 2016. PMID: 26843239.
145. Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans DR, Mohan R, Titt U. Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Med Phys 42(11):6234, 2015. PMID: 26520716.
146. Grant SR, Grosshans DR, Bilton SD, Garcia JA, Amin M, Chambers MS, McGovern SL, McAleer MF, Morrison WH, Huh WW, Kupferman ME, Mahajan A. Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics. Radiother Oncol 116(2):309-15, 2015. e-Pub 2015. PMID: 26232128.
147. Holliday EB, Mitra HS, Somerson JS, Rhines LD, Mahajan A, Brown PD, Grosshans DR. Post-operative proton therapy for chordomas and chondrosarcomas of the spine: Adjuvant vs. salvage radiation therapy. Spine (Phila Pa 1976) 40(8):544-9, 2015. e-Pub 2015. PMID: 25627289.
148. Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Sci Rep 5:9850, 2015. e-Pub 2015. PMID: 25984967.
149. McGovern SL, Okcu MF, Munsell MF, Kumbalasseriyil N, Grosshans DR, McAleer MF, Chintagumpala M, Khatua S, Mahajan A. Outcomes and Acute Toxicities of Proton Therapy for Pediatric Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System. Int J Radiat Oncol Biol Phys 90(5):1143-52, 2014. e-Pub 2014. PMID: 25311260.
150. Grosshans DR, Zhu XR, Melancon A, Allen PK, Poenisch F, Palmer M, McAleer MF, McGovern SL, Gillin M, DeMonte F, Chang EL, Brown PD, Mahajan A. Spot Scanning Proton Therapy for Malignancies of the Base of Skull: Treatment Planning, Acute Toxicities, and Preliminary Clinical Outcomes. Int J Radiat Oncol Biol Phys 90(3):540-6, 2014. e-Pub 2014. PMID: 25304948.
151. Ladra MM, Szymonifka JD, Mahajan A, Friedmann AM, Yong Yeap B, Goebel CP, MacDonald SM, Grosshans DR, Rodriguez-Galindo C, Marcus KJ, Tarbell NJ, Yock TI. Preliminary Results of a Phase II Trial of Proton Radiotherapy for Pediatric Rhabdomyosarcoma. J Clin Oncol 32(33):3762-70, 2014. e-Pub 2014. PMID: 25332253.
152. Stoker JB, Grant J, Zhu XR, Pidikiti R, Mahajan A, Grosshans DR. Intensity modulated proton therapy for craniospinal irradiation: organ-at-risk exposure and a low-gradient junctioning technique. Int J Radiat Oncol Biol Phys 90(3):637-44, 2014. e-Pub 2014. PMID: 25194667.
153. Bishop AJ, Greenfield B, Mahajan A, Paulino AC, Okcu MF, Allen PK, Chintagumpala M, Kahalley LS, McAleer MF, McGovern SL, Whitehead WE, Grosshans DR. Proton Beam Therapy Versus Conformal Photon Radiation Therapy for Childhood Craniopharyngioma: Multi-institutional Analysis of Outcomes, Cyst Dynamics, and Toxicity. Int J Radiat Oncol Biol Phys 90(2):354-61, 2014. e-Pub 2014. PMID: 25052561.
154. Ladra MM, Samantha K. Edgington SK, Szymonifka J, Mahajan A, Khan F, Moteabbed M, Friedmann AM, MacDonald SM, Grosshans DR, Tarbell NJ, Yock TI. A Dosimetric Comparison of Proton Radiotherapy and IMRT in Pediatric RMS Patients Enrolled on a Phase II Proton Study. Radiotherapy Oncology 113(1):77-83, 2014. PMID: 25443861.
155. Gomez DR, Yusuf SW, Munsell MF, Welsh JW, Liao Z, Lin SH, Pan HY, Chang JY, Komaki R, Cox JD, McAleer MF, Grosshans DR. Prospective exploratory analysis of cardiac biomarkers and electrocardiogram abnormalities in patients receiving thoracic radiation therapy with high-dose heart exposure. J Thorac Oncol 9(10):1554-60, 2014. PMID: 25521400.
156. Zhu, XR, Poenisch F, Wu RY, Taylor MB, Sahoo N, Zhang X, Lee AK, Chang EL, Choi S, Pugh T, Frank SJ, Palmer MB, Amin MV, Gillin MT, Mahajan A, Grosshans DR. A Single-Field Integrated Boost Technique for Spot Scanning Proton Therapy. Radiation Oncology, 2014. PMID: 25212571.
157. LeRoux LG, Bredow S, Grosshans DR, Schellingerhout D. Molecular Imaging Detects Impairment in the Retrograde Axonal Transport Mechanism After Radiation-Induced Spinal Cord Injury. Mol Imaging Biol 16(4):504-10, 2014. e-Pub 2014. PMID: 24395625.
158. Shao Y, Sun X, Lou K, Zhu XR, Mirkovic D, Poenisch F, Grosshans DR. In-beam PET imaging for on-line adaptive proton therapy: An initial phantom study. Phys Med Biol 59(13):3373-88, 2014. e-Pub 2014. PMID: 24874943.
159. Tucker SL, Liao Z, Dinh J, Bian SX, Mohan R, Martel MK, Grosshans DR. Is there an impact of heart exposure on the incidence of radiation pneumonitis? Analysis of data from a large clinical cohort. Acta Oncol 53(5):590-6, 2014. e-Pub 2013. PMID: 23992110.
160. Owusu-Agyemang P, Grosshans DR, Arunkumar R, Rebello E, Popovich S, Zavala A, Williams C, Ruiz J, Hernandez M, Mahajan A, Porche V. Non-invasive anesthesia for children undergoing proton radiation therapy. Radiother Oncol 111(1):30-4, 2014. e-Pub 2014. PMID: 24560754.
161. Barney CL, Brown AP, Grosshans DR, McAleer MF, de Groot JF, Puduvalli V, Tucker SL, Crawford CN, Gilbert MR, Brown PD, Mahajan A. Technique, outcomes, and acute toxicities in adults treated with proton beam craniospinal irradiation. Neuro Oncol 16(2):303-9, 2014. e-Pub 2013. PMID: 24311638.
162. Mackin D, Zhu XR, Poenisch F, Heng L, Sahoo N, Kerr M, Holmes C, Li Y, Liii M, Wu R, Suzuki K, Gillin MT, Frank SJ, Grosshans DR, Zhang X. Spot-Scanning Proton Therapy Patient-Specific Quality Assurance: Results from 309 Treatment Plans. International Journal of Particle Therapy, 2014.
163. Liu W, Mohan R, Park P, Liu Z, Li H, Li X, Li Y, Wu R, Sahoo N, Dong L, Zhu XR, Grosshans DR. Dosimetric benefits of robust treatment planning for intensity modulated proton therapy for base-of-skull cancers. Pract Radiat Oncol 4(6):384-91, 2014. e-Pub 2014. PMID: 25407859.
164. Zhu XR, Poenisch F, Li H, Zhang X, Sahoo N, Wu RY, Li X, Lee AK, Chang EL, Choi S, Pugh T, Frank SJ, Gillin MT, Mahajan A, Grosshans DR. A single-field integrated boost treatment planning technique for spot scanning proton therapy. Radiat Oncol 9:202, 2014. e-Pub 2014. PMID: 25212571.
165. Day J, Zienius K, Gehring K, Grosshans DR, Taphoorn M, Grant R, Li J, Brown PD. Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation. Cochrane Database Syst Rev 12:CD011335, 2014. e-Pub 2014. PMID: 25519950.
166. Brown AP, Barney CL, Grosshans DR, McAleer MF, de Groot JF, Puduvalli VK, Tucker SL, Crawford CN, Khan M, Khatua S, Gilbert MR, Brown PD, Mahajan A. Proton Beam Craniospinal Irradiation Reduces Acute Toxicity for Adults With Medulloblastoma. Int J Radiat Oncol Biol Phys 86(2):277-84, 2013. e-Pub 2013. PMID: 23433794.
167. Bian SX, McAleer MF, Vats TS, Mahajan A, Grosshans DR. Pilocytic astrocytoma with leptomeningeal dissemination. Childs Nerv Syst 29(3):441-50, 2013. e-Pub 2012. PMID: 23207974.
168. Dinh J, Stoker J, Georges RH, Sahoo N, Zhu XR, Rath S, Mahajan A, Grosshans DR. Comparison of proton therapy techniques for treatment of the whole brain as a component of craniospinal radiation. Radiat Oncol 8:289, 2013. e-Pub 2013. PMID: 24344645.
169. Amsbaugh MJ, Grosshans DR, McAleer MF, Zhu R, Wages C, Crawford CN, Palmer M, De Gracia B, Woo S, Mahajan A. Proton Therapy for Spinal Ependymomas: Planning, Acute Toxicities and Preliminary Outcomes. Int J Radiat Oncol Biol Phys 83(5):1419-24, 2012. e-Pub 2012. PMID: 22245209.
170. Pinnix CC, Fontanilla HP, Hayes-Jordan A, Subbiah V, Bilton SD, Chang EL, Grosshans DR, McAleer MF, Sulman EP, Woo SY, Anderson P, Green HL, Mahajan A. Whole Abdominopelvic Intensity-Modulated Radiation Therapy for Desmoplastic Small Round Cell Tumor after Surgery. Int J Radiat Oncol Biol Phys 83(1):317-26, 2012. e-Pub 2011. PMID: 22104361.
171. Boehling NS, Grosshans DR, Allen PK, McAleer MF, Burton AW, Azeem S, Rhines LD, Chang EL. Vertebral Compression Fracture Risk After Stereotactic Body Radiotherapy for Spinal Metastases. J Neurosurg Spine 16(4):379-86, 2012. e-Pub 2012. PMID: 22225488.
172. Boehling NS, Grosshans DR, Bluett JB, Palmer MT, Song X, Amos RA, Sahoo N, Meyer JJ, Mahajan A, Woo SY. Dosimetric Comparison of Three-Dimensional Conformal Proton Radiotherapy, Intensity-Modulated Proton Therapy, and Intensity-Modulated Radiotherapy for Treatment of Pediatric Craniopharyngiomas. Int J Radiat Oncol Biol Phys 82(2):643-52, 2012. e-Pub 2011. PMID: 21277111.
173. Amsbaugh MJ, Zhu XR, Palmer M, Poenisch F, Mahajan A, Grosshans DR. Spot Scanning Proton Therapy for Craniopharyngioma. Practical Radiation Oncology 2(4):314-318, 2012. PMID: 24674170.
174. Grosshans DR, Boehling N, Palmer M, Spicer C, Erice R, Cox JD, Komaki R, Chang J. Improving Cardiac Dosimetry: Alternative Beam Arrangements for IMRT Planning in Patients with Carcinoma of the Distal Esophagus. Practical Radiation Oncology 2(1):41-45. e-Pub 2012. PMID: 24674035.
175. Wu PH, Coultrap S, Pinnix C, Davies KD, Tailor R, Ang KK, Browning MD, Grosshans DR. Radiation induces acute alterations in neuronal function. PLoS One 7(5):e37677, 2012. e-Pub 2012. PMID: 22662188.
176. Sharp H, Grosshans DR, Kadia T, Dabaja BS. Cutaneous graft-versus-host disease after proton-based craniospinal irradiation for recurrent Philadelphia-positive acute lymphoblastic leukemia. BMJ Case Rep 2012, 2012. e-Pub 2012. PMID: 22787181.
177. Moeller BJ, Chintagumpala M, Philip JJ, Grosshans DR, McAleer MF, Woo SY, Gidley PW, Vats TS, Mahajan A. Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy. Radiat Oncol 2(6):1-7, 2011. e-Pub 2011. PMID: 21635776.
178. Grosshans DR, Meyers CA, Allen PK, Davenport SD, Komaki R. Neurocognitive function in patients with small cell lung cancer: effect of prophylactic cranial irradiation. Cancer 112(3):589-95, 2008. PMID: 18098269.
179. Hellier JL, Grosshans DR, Coultrap SJ, Jones JP, Dobelis P, Browning MD, Staley KJ. NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network. J Neurophysiol 98(5):2818-26, 2007. e-Pub 2007. PMID: 17728388.
180. Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD. Tyrosine dephosphorylation and ethanol inhibition of N-Methyl-D-aspartate receptor function. J Biol Chem 278(13):11020-5, 2003. e-Pub 2003. PMID: 12536146.
181. Grosshans DR, Clayton DA, Coultrap SJ, Browning MD. Analysis of glutamate receptor surface expression in acute hippocampal slices. Sci STKE 2002(137):PL8, 2002. PMID: 12072555.
182. Clayton DA, Grosshans DR, Browning MD. Aging and surface expression of hippocampal NMDA receptors. J Biol Chem 277(17):14367-9, 2002. e-Pub 2002. PMID: 11891215.
183. Grosshans DR, Clayton DA, Coultrap SJ, Browning MD. LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 5(1):27-33, 2002. PMID: 11740502.
184. Grosshans DR, Browning MD. Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor. J Neurochem 76(3):737-44, 2001. PMID: 11158244.
185. Oh JJ, Grosshans DR, Wong SG, Slamon DJ. Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells. Nucleic Acids Res 27(20):4008-17, 1999. PMID: 10497265.
186. Péterfy M, Gyuris T, Grosshans DR, Cuaresma CC, Takács L. Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein. Genomics 47(2):200-6, 1998. PMID: 9479492.
187. Chang M, McNinch J, Elias C, Manthey CL, Grosshans DR, Meng T, Boone T, Andrew DP. Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. J Biol Chem 272(40):25229-37, 1997. PMID: 9312138.
188. Wilson CA, Payton MN, Elliott GS, Buaas FW, Cajulis EE, Grosshans DR, Ramos L, Reese DM, Slamon DJ, Calzone FJ. Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b. Oncogene 14(1):1-16, 1997. PMID: 9010228.

Invited Articles

1. Dinh J, Mahajan A, Palmer M, Grosshans DR. Particle therapy for central nervous system tumors in pediatric and adult patients. Translational Cancer Research 1(3). e-Pub 2012.
2. Grosshans, DR.. Radiation Therapy for Childhood Cancers. Pediatrics for Parents 27(3):24-25, 2011.