Eleonora Dondossola, Ph.D.
Department of Genitourinary Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Regular Member, Institutional Committee, Department of (Cancer Biology, Therapeutics and Pharmacology Programs), the Graduate School of Biomedical Sciences, UT MDACC, Houston, Tx, The University of Texas MD Anderson Cancer Center, Houston, Texas
Assistant Professor, Department of Genitourinary Medical Oncology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2010 | University Vita-Salute San Raffaele, Milan, IT, Cell and Molecular Biology, Ph.D |
| 2006 | University Vita-Salute San Raffaele, Milan, IT, Molecular and Cellular Medical Biotechnology, M.Sc |
| 2004 | University Vita-Salute San Raffaele, Milan, IT, Medical and Pharmaceutical Biotechnology, B.Sc |
Postgraduate Training
| 2013-2016 | Postdoctoral Fellow, Cancer Biology Intravital Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2011-2013 | Postdoctoral Fellow, Tumor Angiogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2010-2011 | Postdoctoral Fellow, Tumor Vessel Biology, San Raffaele Scientific Institute, Milan |
Experience & Service
Academic Appointments
Instructor, Department of Genitourinary Medical Oncology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2022
Lecturer, University Vita-Salute San Raffaele, Milan, 2008 - 2024
Other Appointments/Responsibilities
Adjunct Faculty, Department of Engineering, Rice University, Houston, TX, 2023 - Present
Institutional Committee Activities
Chair, Junior Faculty Committee, 2024 - Present
Co-Chair, RFA Task Force, 2024 - Present
Chair-elect, Junior Faculty Committee, 2023 - 2024
Co-Chair, Italian Scientists and Scholars in North America Foundation, West South - Central Chapter, 2022 - Present
Senator, Faculty Senate, 2019 - Present
Member, Junior Faculty Committee, 2018 - Present
Communication Vice Chair, Postdoctoral Association Executive Committee, 2015 - 2016
Honors & Awards
| Ministerial Research Fellowship, Italian Ministry of School and Research | |
| Travel grant, 2014 ISSNAF Young Investigator Awards - Biomedicine, Italian Embassy, Washington | |
| The AMGEN Award in Basic Science Research, University of Texas MD Anderson Cancer Center | |
| Individual Investigator Award, Cancer Prevention and Research Institute of Texas (CPRIT) | |
| Descience Contest - finalist, MIT Media Lab | |
| The Lupe C. Garcia Fellowship in Cancer Research, University of Texas MD Anderson Cancer Center | |
| Gerald B. Grindey Memorial Scholar-in-Training Award, AACR | |
| AFLAC Scholar-in-Training Award, AACR-Tumor Metastasis Special Conference | |
| The 2016 Mark Walter, Brent Nicklas, Adrianne and Jerry Cohen–PCF Young Investigator Award, Prostate Cancer Foundation | |
| The Rolanette and Berdon Lawrence Bone Research Award, The Rolanette and Berdon Lawrence Bone Disease Program of Texas | |
| Selected as part of the 100 Italian Influential Women in STEM https://100esperte.it/search?id=302 | |
| Nature Research Award for Inspiring Science - Top 10 Finalist | |
| 40 Under 40 in Cancer, The Lynx Group, Upstream Partners, the Association for Value-Based Cancer Care, NCODA, and Swim Across America | |
| AACR Early Stage Investigator Scholar Award, AACR Annual Meeting, Inaugural Class |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Maksimovic S, Boscolo NC, La Posta L, Barrios S, Moussa MJ, Gentile E, Pesquera PI, Li W, Chen J, Gomez JA, Basi A, Burks JK, Alvarez-Breckenridge C, Gao J, Campbell MT, Dondossola E. Antiangiogenic Tyrosine Kinase Inhibitors have Differential Efficacy in Clear Cell Renal Cell Carcinoma in Bone. Cancer Res Commun 4(10):2621-2637, 2024. PMID: 39248577.
- Paindelli C, Parietti V, Barrios S, Shepherd P, Pan T, Wang WL, Satcher RL, Logothetis CJ, Navone N, Campbell MT, Mikos AG, Dondossola E. Bone mimetic environments support engineering, propagation, and analysis of therapeutic response of patient-derived cells, ex vivo and in vivo. Acta Biomater 178:83-92, 2024. e-Pub 2024. PMID: 38387748.
- Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, Paindelli C, Parietti V, Mikos AG, Lodi A, Bagrodia A, Elliott A, McKay RR, Murali R, Tiziani S, Kettenbach AN, Bottini N. Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Sci Adv 10(5):eadg7887, 2024. e-Pub 2024. PMID: 38295166.
- Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G. SMARCB1 regulates the hypoxic stress response in sickle cell trait. Proc Natl Acad Sci U S A 120(21):e2209639120, 2023. PMID: 37186844.
- Mossa F, Robesti D, Sumankalai R, Corey E, Titus M, Kang Y, Zhang J, Briganti A, Montorsi F, Vellano CP, Marszalek JR, Frigo DE, Logothetis CJ, Gujral TS, Dondossola E. Subtype and site specific-induced metabolic vulnerabilities in prostate cancer. Mol Cancer Res 21(1):51-61, 2023. e-Pub 2022. PMID: 36112348.
- Parlani M, Bedell ML, Mikos AG, Friedl P, Dondossola E. Dissecting the recruitment and self-organization of αSMA-positive fibroblasts in the foreign body response. Sci Adv 8(51):eadd0014, 2022. e-Pub 2022. PMID: 36542704.
- Parlani M, Boccalatte F, Yeaton A, Wang F, Zhang J, Aifantis I, Dondossola E. Radium 223 induces transient functional bone marrow toxicity. J Nucl Med 63(10):1544-1550, 2022. e-Pub 2022. PMID: 35177425.
- Paindelli C, Casarin S, Wang F, Diaz-Gomez L, Zhang J, Mikos AG, Logothetis CJ, Friedl P, Dondossola E. Enhancing Radium 223 treatment efficacy by anti-beta 1 integrin targeting. J Nucl Med 63(7):1039-1045, 2022. e-Pub 2021. PMID: 34711616.
- Sarti, M, Parlani, M, Diaz-Gomez, LA, Mikos, AG, Cerveri, P, Casarin, S, Dondossola, E. Deep Learning for Automated Analysis of Cellular and Extracellular Components of the Foreign Body Response in Multiphoton Microscopy Images. Frontiers in Bioengineering and Biotechnology 9, 2022. PMID: 35145962.
- Shapiro DD, Soeung M, Perelli L, Dondossola E, Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MHG, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P. Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies. Cancers (Basel) 13(23), 2021. e-Pub 2021. PMID: 34885132.
- Bello T, Paindelli C, Diaz-Gomez LA, Melchiorri A, Mikos AG, Nelson PS, Dondossola E, Gujral TS. Computational modeling identifies multitargeted kinase inhibitors as effective therapies for metastatic, castration-resistant prostate cancer. Proc Natl Acad Sci U S A 118(40), 2021. e-Pub 2021. PMID: 34593636.
- Casarin S, Dondossola E. An agent-based model of prostate Cancer bone metastasis progression and response to Radium223. BMC Cancer 20(1):605, 2020. e-Pub 2020. PMID: 32600282.
- Dondossola E, Casarin S, Paindelli C, De-Juan-Pardo EM, Hutmacher DW, Logothetis CJ, Friedl P. Radium 223-Mediated Zonal Cytotoxicity of Prostate Cancer in Bone. J Natl Cancer Inst 111(10):1042-1050, 2019. PMID: 30657953.
- Paindelli C, Navone N, Logothetis CJ, Friedl P, Dondossola E. Engineered bone for probing organotypic growth and therapy response of prostate cancer tumoroids in vitro. Biomaterials 197(None):296-304, 2019. e-Pub 2019. PMID: 30682644.
- Dondossola E, Alexander S, Holzapfel BM, Filippini S, Starbuck MW, Hoffman RM, Navone N, De-Juan-Pardo EM, Logothetis CJ, Hutmacher DW, Friedl P. Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone. Sci Transl Med 10(452), 2018. PMID: 30068572.
- Dondossola E, Holzapfel BM, Alexander S, Filippini S, Hutmacher DW, Friedl P. Dissecting the foreign body response to biomaterials by non-linear intravital microscopy. Nat Biomed Eng 1(0007):None, 2016. e-Pub 2016. PMID: None.
- Curnis F, Dallatomasina A, Bianco M, Gasparri A, Sacchi A, Colombo B, Fiocchi M, Perani L, Venturini M, Tacchetti C, Sen S, Borges R, Dondossola E, Esposito A, Mahata SK, Corti A. Regulation of tumor growth by circulating full-length chromogranin A. Oncotarget 7(45):72716-72732, 2016. PMID: 27683038.
- Bianco M, Gasparri A, Generoso L, Assi E, Colombo B, Scarfò L, Bertilaccio MT, Scielzo C, Ranghetti P, Dondossola E, Ponzoni M, Caligaris-Cappio F, Ghia P, Corti A. Inhibition of chronic lymphocytic leukemia progression by full length chromogranin A and its N-terminal fragment in mouse models. Oncotarget None(None):None. e-Pub 2016. PMID: 27203389.
- Dondossola E, Dobroff AS, Marchiò S, Cardó-Vila M, Hosoya H, Libutti SK, Corti A, Sidman RL, Arap W, Pasqualini R. Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors. Proc Natl Acad Sci U S A 113(8):2223-8, 2016. e-Pub 2016. PMID: 26858439.
- Christianson DR, Dobroff AS, Proneth B, Zurita AJ, Salameh A, Dondossola E, Makino J, Bologa CG, Smith TL, Yao VJ, Calderone TL, O'Connell DJ, Oprea TI, Kataoka K, Cahill DJ, Gershenwald JE, Sidman RL, Arap W, Pasqualini R. Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis. Proc Natl Acad Sci U S A 112(8):2521-6, 2015. e-Pub 2015. PMID: 25659743.
- Mintz PJ, Rietz AC, Cardó-Vila M, Ozawa MG, Dondossola E, Do KA, Kim J, Troncoso P, Logothetis CJ, Sidman RL, Pasqualini R, Arap W. Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer. Proc Natl Acad Sci U S A 112(8):2515-20, 2015. e-Pub 2015. PMID: 25675522.
- Dondossola E, Corti A, Sidman RL, Arap W, Pasqualini R. Bone marrow-derived CD13(+) cells sustain tumor progression: A potential non-malignant target for anticancer therapy. Oncoimmunology 3:e27716, 2014. e-Pub 2014. PMID: 25339996.
- Dondossola E, Rangel R, Guzman-Rojas L, Barbu EM, Hosoya H, St John LS, Molldrem JJ, Corti A, Sidman RL, Arap W, Pasqualini R. CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(51):20717-22, 2013. e-Pub 2013. PMID: 24297924.
- Guzman-Rojas L, Rangel R, Salameh A, Edwards JK, Dondossola E, Kim YG, Saghatelian A, Giordano RJ, Kolonin MG, Staquicini FI, Koivunen E, Sidman RL, Arap W, Pasqualini R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. Proc Natl Acad Sci U S A 109(5):1637-42, 2012. e-Pub 2012. PMID: 22307623.
- Dondossola E, Crippa L, Colombo B, Ferrero E, Corti A. Chromogranin A regulates tumor self-seeding and dissemination. Cancer Res 72(2):449-59, 2012. e-Pub 2011. PMID: 22139379.
- Veschini L, Crippa L, Dondossola E, Doglioni C, Corti A, Ferrero E. The vasostatin-1 fragment of chromogranin A preserves a quiescent phenotype in hypoxia-driven endothelial cells and regulates tumor neovascularization. FASEB J 25(11):3906-14, 2011. e-Pub 2011. PMID: 21825034.
- Dondossola E, Gasparri AM, Colombo B, Sacchi A, Curnis F, Corti A. Chromogranin A restricts drug penetration and limits the ability of NGR-TNF to enhance chemotherapeutic efficacy. Cancer Res 71(17):5881-90, 2011. e-Pub 2011. PMID: 21799030.
- Roatta S, Passatore M, Novello M, Colombo B, Dondossola E, Mohammed M, Losano G, Corti A, Helle KB. The chromogranin A- derived N-terminal peptide vasostatin-I: In vivo effects on cardiovascular variables in the rabbit. Regul Pept 168(1-3):10-20, 2011. e-Pub 2011. PMID: 21362443.
- Dondossola E, Gasparri A, Bachi A, Longhi R, Metz-Boutigue MH, Tota B, Helle KB, Curnis F, Corti A. Role of vasostatin-1 C-terminal region in fibroblast cell adhesion. Cell Mol Life Sci 67(12):2107-18, 2010. e-Pub 2010. PMID: 20217454.
- Curnis F, Longhi R, Crippa L, Cattaneo A, Dondossola E, Bachi A, Corti A. Spontaneous formation of L-isoaspartate and gain of function in fibronectin. J Biol Chem 281(47):36466-76, 2006. e-Pub 2006. PMID: 17015452.
Other Articles
- Hahn, AW, Siddiqui, BA, Leo, J, Dondossola, E, Basham, KJ, Miranti, CK, Frigo, DE Cancer Cell–Extrinsic Roles for the Androgen Receptor in Prostate Cancer. Endocrinology 164(6), 2023. PMID: 37192413.
- Hahn AW, Siddiqui BA, Leo J, Dondossola E, Basham KJ, Miranti CK, Frigo DE Cell-Extrinsic Roles for the Androgen Receptor in Prostate Cancer. Endocrinology None(None):None, 2023. PMID: None.
- Leo J, Dondossola E, Basham KJ, Wilson NR, Alhalabi O, Gao J, Kurnit KC, White MG, McQuade JL, Westin SN, Wellberg EA, Frigo DE Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer. Endocrinology 164(6):None, 2023. PMID: 37154098.
- Dondossola E, Friedl P Host responses to implants revealed by intravital microscopy. Nature Review Material 7 (1)(None):p. 6-22, 2022. PMID: None.
- Sheth RA, Perkons N, Dondossola E, Subudhi SK, Gade TP, Tam AL Patient-Derived Xenograft Tumor Models: Overview and Relevance to IR. J Vasc Interv Radiol 29(6):880-882.e1, 2018. PMID: 29798759.
Book Chapters
- Dondossola E, Paindelli C. In vitro 3D modeling for prostate cancer. In: Biomaterials for 3D Tumor Modeling. None. Elsevier, 2020.
Grant & Contract Support
| Title: | Overcoming Therapy Resistance by Integrated Computational Modeling of The Bone Metastatic Niche in Prostate and Renal Cancers |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| Title: | The Bone Metastasis Immunological Niche: Unraveling its Complexity and Role in Therapy Response and Resistance |
| Funding Source: | DOD |
| Role: | PI |
| Title: | Investigation of the Role of Epithelial-Mesenchymal Plasticity in Renal Cell Carcinoma |
| Funding Source: | NIH |
| Role: | Co-I |
| Title: | Dissecting Radium 223 Mechanisms of Action and Therapeutic Efficacy in Preclinical Models of Prostate Cancer Lesions in Bone |
| Funding Source: | Bayer |
| Role: | PI |
| Title: | Combining Anti-Angiogenesis and Cell- Based Immunotherapy to Eradicate Metastatic Renal Cell Carcinoma to Bone |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Title: | Dissecting the Effects of Radium 223 on Bone Health |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Title: | Targeting Therapeutic Resistance in Clear Cell Renal Cell Carcinoma Bone Metastases with Radium 223 |
| Funding Source: | Kure It Cancer Research |
| Role: | PI |
| Title: | Integrating In vivo and In Silico Models of Prostate Cancer-Bone Interactions to Overcome Anti-Tumor Therapy Resistance |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Title: | Targeting the Osteogenic Niche for Preventing Kidney Cancer Bone Metastasis Progression |
| Funding Source: | DOD-KCRP |
| Role: | Co-I |
| Title: | Tissue Engineered Platforms Combined to ex vivo PDX Engineering and Direct in vivo Transfer for Co - Clinical strategies |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Title: | Targeting the Osteogenic Niche in the AML Bone Marrow Microenvironment Using ALK 2 Inhibitor TP-0184 |
| Funding Source: | Tolero Pharmaceuticals, Inc |
| Role: | Co-I |
| Title: | Illuminating the Resistance Niche to Chemotherapy in Osteosarcoma |
| Funding Source: | Alex Lemonade Stand Foundation |
| Role: | Co-I |
| Title: | Targeting Kinases in Castration-Resistant Prostate Cancer Bone Metastasis |
| Funding Source: | American Association for Cancer Research (AACR) |
| Role: | PI |
| Title: | Effect of AP-002 on cancer bone metastases and bone resorption |
| Funding Source: | Altum Pharmaceuticals Inc |
| Role: | PI |
| Title: | Targeting Metabolic Vulnerabilities in Metastatic Prostate Cancer to Bone |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Title: | Targeting Kinases and Associated Networks in Metastatic Castrate-Resistant Prostate Cancer. Interdisciplinary Approaches in Cancer Metastasis |
| Funding Source: | Sage Bionetworks/National Cancer Institute |
| Role: | Co-I |
| Title: | Programs of Prostate Cancer Invasion into Bone: Morphological, Molecular and Therapeutic Consequences |
| Funding Source: | The Rolanette and Berdon Lawrence Bone Disease Program of Texas |
| Role: | PI |
| Title: | Preclinical Targeting of Early-Stage and Established Prostate Cancer Lesions in Bone by Radium-223: Impact on Tumor Cells, Stroma and Markers of Response |
| Funding Source: | Prostate Cancer Foundation |
| Role: | PI |
| Title: | Preclinical Intravital Microscopy of Prostate Cancer Lesions in Bone: Identification and Eradication of Survival Niches by Combination Therapy |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
Patient Reviews
CV information above last modified November 27, 2024