Ellen Ackerstaff, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1998 | University of Bremen, Bremen, DEU, Dr. rer. nat. (PHD), Physics & Electrical Engineering |
| 1994 | Westfälische Wilhelms-Universität Münster, Münster, DEU, Dipl.- Phys. (MS), Physics |
Postgraduate Training
| 2012-2012 | Early Career Women Faculty Professional Development, American Association of Medical Colleges, Potomac, MD |
| 1998-2001 | Research Fellowship, Division of MR Research, Russell H. Morgan Dept. of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD |
Experience & Service
Academic Appointments
Assistant Attending Physicist, Department of Medical Physics, Memorial Hospital for Cancer and Allied Diseases, New York, NY, 2012 - 2022
Assistant Laboratory Member, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 2012 - 2022
Instructor, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 2006 - 2012
Member, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, MD, 2005 - 2006
Research Associate, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 2005 - 2006
Research Associate, Department of Division of MR Research, Russell H. Morgan Dept. of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 2001 - 2006
Research & Teaching Assistant, Department of Physics & Electrical Engineering, University of Bremen, Breman, 1996 - 1998
Selected Publications
Peer-Reviewed Articles
- Li Z, Nguyen C, Jang H, Hoang D, Min S, Ackerstaff E, Koutcher JA, Shi L. Multimodal imaging of metabolic activities for distinguishing subtypes of breast cancer. Biomed Opt Express 14(11):5764-5780, 2023. e-Pub 2023. PMID: 38021123.
- Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours. Nature 591(7851):652-658, 2021. e-Pub 2021. PMID: 33588426.
- Mane MM, Cohen IJ, Ackerstaff E, Shalaby K, Ijoma JN, Ko M, Maeda M, Albeg AS, Vemuri K, Satagopan J, Moroz A, Zurita J, Shenker L, Shindo M, Nickles T, Nikolov E, Moroz MA, Koutcher JA, Serganova I, Ponomarev V, Blasberg RG. Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy. Mol Ther Oncolytics 18:382-395, 2020. e-Pub 2020. PMID: 32913888.
- Bendau E, Smith J, Zhang L, Ackerstaff E, Kruchevsky N, Wu B, Koutcher JA, Alfano R, Shi L. Distinguishing metastatic triple-negative breast cancer from nonmetastatic breast cancer using second harmonic generation imaging and resonance Raman spectroscopy. J Biophotonics 13(7):e202000005, 2020. e-Pub 2020. PMID: 32219996.
- Jin S, Han S, Stoyanova R, Ackerstaff E, Cho H. Pattern recognition analysis of dynamic susceptibility contrast (DSC)-MRI curves automatically segments tissue areas with intact blood-brain barrier in a rat stroke model: A feasibility and comparison study. J Magn Reson Imaging 51(5):1369-1381, 2020. e-Pub 2019. PMID: 31654463.
- Bodo S, Campagne C, Thin TH, Higginson DS, Vargas HA, Hua G, Fuller JD, Ackerstaff E, Russell J, Zhang Z, Klingler S, Cho H, Kaag MG, Mazaheri Y, Rimner A, Manova-Todorova K, Epel B, Zatcky J, Cleary CR, Rao SS, Yamada Y, Zelefsky MJ, Halpern HJ, Koutcher JA, Cordon-Cardo C, Greco C, Haimovitz-Friedman A, Sala E, Powell SN, Kolesnick R, Fuks Z. Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. J Clin Invest 129(2):786-801, 2019. e-Pub 2019. PMID: 30480549.
- Han S, Stoyanova R, Lee H, Carlin SD, Koutcher JA, Cho H, Ackerstaff E. Automation of pattern recognition analysis of dynamic contrast-enhanced MRI data to characterize intratumoral vascular heterogeneity. Magn Reson Med 79(3):1736-1744, 2018. e-Pub 2017. PMID: 28727185.
- Patel BB, Ackerstaff E, Serganova IS, Kerrigan JE, Blasberg RG, Koutcher JA, Banerjee D. Tumor stroma interaction is mediated by monocarboxylate metabolism. Exp Cell Res 352(1):20-33, 2017. e-Pub 2017. PMID: 28132882.
- Simões RV, Serganova IS, Kruchevsky N, Leftin A, Shestov AA, Thaler HT, Sukenick G, Locasale JW, Blasberg RG, Koutcher JA, Ackerstaff E. Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment. Neoplasia 17(8):671-84, 2015. PMID: 26408259.
- Viola-Villegas NT, Carlin SD, Ackerstaff E, Sevak KK, Divilov V, Serganova I, Kruchevsky N, Anderson M, Blasberg RG, Andreev OA, Engelman DM, Koutcher JA, Reshetnyak YK, Lewis JS. Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc Natl Acad Sci U S A 111(20):7254-9, 2014. e-Pub 2014. PMID: 24785505.
- Cho H, Ackerstaff E, Carlin S, Lupu ME, Wang Y, Rizwan A, O'Donoghue J, Ling CC, Humm JL, Zanzonico PB, Koutcher JA. Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia. Neoplasia 11(3):247-59, 2p following 259, 2009. PMID: 19242606.
- Ackerstaff E, Artemov D, Gillies RJ, Bhujwalla ZM. Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism. Neoplasia 9(12):1138-51, 2007. PMID: 18084621.
- Ackerstaff E, Pflug BR, Nelson JB, Bhujwalla ZM. Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. Cancer Res 61(9):3599-603, 2001. PMID: 11325827.
Editorials
- Ackerstaff E, López-Larrubia P. Editorial: Differentiating brain cancers and glioblastoma through imaging methodologies. Front Oncol 13:1351874, 2023. PMID: 38164194.
Patient Reviews
CV information above last modified December 11, 2024