Ellen Ackerstaff, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Assistant Professor, Cancer Systems Imaging, Diagnostic Imaging, UT MD Anderson, Houston, Texas
Core Investigator, Cancer Neuroimaging Research Program, Cancer Systems Imaging, UT MD Anderson, Houston, Texas
Education & Training
Degree-Granting Education
| 1998 | Department of Physics and Electrical Engineering, University of Bremen, Bremen, DE, Experimental Physics and Biophysics, Dr. rer. nat. (Ph.D.) |
| 1994 | Westfälische Wilhelms-Universität Münster, Münster, DE, Physics; Major: Medical Physics and Biophysics, Dipl.- Phys. (exceeds typical M.Sc. degree) |
Postgraduate Training
| 2012-2012 | Early Career Women Faculty Professional Development, American Association of Medical Colleges (AAMC), Potomac, Maryland |
| 1998-2001 | Postdoctoral Research Fellow, Preclinical Cancer Research: Prostate & Breast Cancer Cell Invasion & Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland |
Experience & Service
Faculty Academic Appointments
Assistant Professor - Ad Interim, Cancer Systems Imaging, UT MD Anderson, Houston, Texas, 2023 - 2023
Non-Employee Contingent, Department of Medical Physics, Memorial Hospital for Cancer and Allied Diseases, New York, NY, 2022 - 2022
Non-Employee Contingent, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 2022 - 2022
Assistant Attending Physicist, Department of Medical Physics, Memorial Hospital for Cancer and Allied Diseases, New York, NY, 2012 - 2022
Assistant Laboratory Member, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 2012 - 2022
Instructor, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 2006 - 2012
Instructor, Department of Medical Physics, Memorial Hospital for Cancer and Allied Diseases, New York, New York, 2006 - 2012
Research Associate, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 2005 - 2006
Research Associate, Russell H. Morgan Dept. of Radiology & Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, 2001 - 2006
Other Professional Positions
Various roles, Dr. Jason A. Koutcher’s Research Laboratory Memorial Sloan Kettering Cancer Center,, New York, NY, 2006 - 2022
Member, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, MD, 2005 - 2006
Volunteer – Parental Business, Website design, programming & maintenance (http://www.nietberg.de), Bad Bentheim, Bad Bentheim, Germany, 2003 - 2026
Volunteer - Adult Basic Education, Individualized teaching of English (reading, writing) and mathematics to US citizens with limited school education, Greater Homewood Community Services, Baltimore, MD, 2001 - 2006
Various roles, Johns Hopkins University School of Medicine, Baltimore, MD, 1998 - 2006
Research & Teaching Assistant, University of Bremen, Breman, 1996 - 1998
Student Assistant - Part Time Employment, Instructed physicians, medical students, and employees in the use of computers and software. Hardware & Software maintenance, Klinik und Poliklinik für Allgemeine Orthopädie, Universitätskliniken, Münster, 1993 - 1994
Laboratory Assistant (Temporary employee), Processing of environmental samples and data processing for environmental analyses, Gesellschaft für Arbeitsplatz – und Umweltanalytik mbH, Münster-Roxel, Münster, 1992 - 1992
Volunteer – Parental Business, Agrotourism, Restaurant, and Agriculture, Bad Bentheim, Bad Bentheim, 1986 - 1998
Intramural Institutional Committee Activities
Poster Judge, Annual Retreat of the Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 2026
Reviewer & Judge of Posters, 14th Annual Metabolism in Cancer Symposium Poster Competition, UT MD Anderson, 2025
Reviewer & Judge of Posters, 13th Annual Cancer Metabolism Symposium Poster Competition, UT MD Anderson, 2024
Senator, Faculty Senate, UT MD Anderson, 2024 - 2025
Reviewer & Judge of Posters, 12th Annual Cancer Metabolism Symposium Poster Competition, UT MD Anderson, 2023
Member, Memorial Sloan Kettering (MSK) Institutional Animal Care and Use Committee (IACUC), Memorial Sloan Kettering Cancer Center, 2020 - 2022
Editorial Activities
Research Topic Editor, Research Topic: Differentiating Brain Cancers and Glioblastoma through Imaging Methodologies, Frontiers in Oncology, 2022 - 2023
Research Topic Editor, Research Topic: Women in Cancer Imaging and Image-directed Interventions Vol II: 2022, Frontiers in Oncology, 2022
Research Topic Editor, Research Topic: Women in Cancer Imaging and Image-directed Interventions: 2021, Frontiers in Oncology, 2021
Associate Editor, Frontiers in Oncology | Cancer Imaging & Image-directed Interventions, 2020 - Present
Honors & Awards
| 2024 | Faculty Senate Nomination, Faculty Senate |
| 2012 | Awarded competitive admission to the American Association of Medical Colleges (AAMC) Early Career Women Faculty Professional Development Seminar, American Association of Medical Colleges (AAMC), Washington, DC |
| 2010 | Nominated for active membership in the American Association for Cancer Research (AACR), American Association for Cancer Research (AACR), Philadelphia, PA |
| 2005 | Stipend for Young Scientists, International Conference on Magnetic Resonance in Biological Systems (ICMRBS) Council |
| 2004 | Bill Negendank Student Poster Award, Poster, Workshop on Advances in Experimental and Clinical Cancer Research |
| 2001 | Educational Stipends for Students and Postdoctoral Trainees, International Society for Magnetic Resonance in Medicine (ISMRM), Concord, CA |
| 2000 - 2001 | Educational Stipends for Students and Postdoctoral Trainees, International Society for Magnetic Resonance in Medicine (ISMRM), Concord, CA |
| 1998 | Stipend for Young Scientists, University of Bremen, Bremen, Germany |
| 1996 | Stipend for Young Scientists, University of Bremen, Bremen, Germany |
| 1996 | Stipend for Young Scientists, International Conference on Magnetic Resonance in Biological Systems (ICMRBS) Council |
| 1995 | Research Scholarship - Funding of research conducted in the Ph.D. program, University of Bremen, Bremen, Germany |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. Developing a novel PET tracer to visualize glioma invasion. Poster. 14th Annual Metabolism in Cancer Symposium 2025. Houston, Texas, US.
- 2025. Elucidating the Metabolic Tumor Microenvironment in Cancer. Invited. 14th Annual Metabolism in Cancer Symposium 2025. Houston, Texas, US.
- 2025. Enhanced drug delivery via blood-brain barrier disruption by transcranial magnetic resonance-guided focused ultrasound (MRgFUS). Poster. CNP (Cancer Neuroscience Program) Scientific Retreat. Houston, Texas, US.
- 2025. Development of a novel PET tracer for visualizing glioma invasion. Poster. CNP (Cancer Neuroscience Program) Scientific Retreat. Houston, Texas, US.
- 2025. Bridging Scales in Preclinical Brain Imaging: From Ex Vivo Light Sheet Fluorescence Microscopy (LSFM) to In Vivo MRI and PET. Poster. CNP (Cancer Neuroscience Program) Scientfic Retreat. Houston, Texas, US.
Regional Presentations
- 1994. Detection Systems in Matrix-Assisted Laser Desorption / Ionization (MALDI) Mass Spectrometry. Invited. Invitation by Prof. Dr. Adalbert Mayer-Heinricy. Bremen, DE.
- 1994. Laser Desorption / Ionization Mass Spectrometry – Theory, Design, and Detection Systems. Invited. Invitation by Dr. Horst-Günter Rubahn and Prof. Dr. J. Peter Toennies. Göttingen, DE.
National Presentations
- 2025. In Vivo Functional & Molecular Imaging of the Tumor Microenvironment. Invited. Invitation by Prof. Dr. Christopher Chad Quarles. Houston, Texas, US.
- 2025. Preclinical In Vivo Functional & Molecular Imaging of the Tumor Microenvironment. Invited. Invitation by Prof. Dr. Thoralf Niendorf, Head of B.U.F.F. Berlin-Buch, DE.
- 2022. Functional and Molecular Imaging of the Tumor Microenvironment. Invited. Invitation by Dr. Todd Sasser, Head of PCI Applications Americas. Billerica, Massachusetts, US.
- 2022. Functional and Molecular Imaging of the Tumor Microenvironment. Sylvester Comprehensive Cancer Center. Invited. Invitation by Prof. Dr. Radka Stoyanova and Prof. Dr. Scott M. Welford. Miami, Florida, US.
- 2022. Functional and Molecular Imaging of the Tumor Microenvironment. Houston Methodist Research Institute Translational Imaging Center. Invited. Invitation by Prof. Dr. Christof Karmonik and Prof. Dr. Diego R. Martin. Houston, Texas, US.
- 2012. Hypoxia – Role in cancer progression, cell metabolism, and treatment response. Invited. Invitation by Dr. Radka S. Stoyanova. Miami, Florida, US.
- 2006. Functional Imaging of the Invasive Phenotype of Human Breast and Prostate Cancer Cells. Invited. Invitation by Dr. Jason A. Koutcher. New York, New York, US.
International Presentations
- 2006. MRI and MRS of Cancer Invasion & Metabolism. Invited. Invitation by Prof. Dr. Klaus Wienhard. Köln, DE.
Selected Publications
Peer-Reviewed Articles
- Serganova I, Colombo G, Ballesio F, Kang JH, Karakousi T, Esposito TVF, Ackerstaff E, Santella A, Blasberg R, Pillarsetty NVK, Schreier A, Andreopoulou E, Demaria S, Lund AW, Gherardini PF, Zappasodi R. A tumor metabolism-angiogenesis-immune axis governs immunotherapy responses. bioRxiv, 2026. e-Pub 2026. PMID: 42124721.
- Jang HJ, Li Z, Bahrenburg F, Ackerstaff E, Koutcher JA, Shi LY. Pre-processing for precise super-resolution multimodal image analysis. Adv Chem Microsc Life Sci Transl Med 12855:1285505, 2024. e-Pub 2024.
- Li Z, Nguyen C, Jang H, Hoang D, Min SS, Ackerstaff E, Koutcher JA, Shi L. Multimodal imaging of metabolic activities for distinguishing subtypes of breast cancer. Biomed Opt Express 14(11):5764-5780, 2023. e-Pub 2023. PMID: 38021123.
- Jang HJ, Li Z, Li YJ, Bagheri P, Ackerstaff E, Koutcher JA, Shi LY. Ultrafast nonlinear multimodal metabolic imaging platform for studying aging and diseases. ULTRAFAST NONLINEAR IMAGING AND SPECTROSCOPY X 12228:1222805, 2022. e-Pub 2022.
- Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours. Nature 591(7851):652-658, 2021. e-Pub 2021. PMID: 33588426.
- Mane MM, Cohen IJ, Ackerstaff E, Shalaby K, Ijoma JN, Ko M, Maeda M, Albeg AS, Vemuri K, Satagopan J, Moroz A, Zurita J, Shenker L, Shindo M, Nickles T, Nikolov E, Moroz MA, Koutcher JA, Serganova I, Ponomarev V, Blasberg RG. Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy. Mol Ther Oncolytics 18:382-395, 2020. e-Pub 2020. PMID: 32913888.
- Bendau E, Smith J, Zhang L, Ackerstaff E, Kruchevsky N, Wu B, Koutcher JA, Alfano R, Shi L. Distinguishing metastatic triple-negative breast cancer from nonmetastatic breast cancer using second harmonic generation imaging and resonance Raman spectroscopy. J Biophotonics 13(7):e202000005, 2020. e-Pub 2020. PMID: 32219996.
- Jin S, Han S, Stoyanova R, Ackerstaff E, Cho H. Pattern recognition analysis of dynamic susceptibility contrast (DSC)-MRI curves automatically segments tissue areas with intact blood-brain barrier in a rat stroke model: A feasibility and comparison study. J Magn Reson Imaging 51(5):1369-1381, 2020. e-Pub 2020. PMID: 31654463.
- Bodo S, Campagne C, Thin TH, Higginson DS, Vargas HA, Hua G, Fuller JD, Ackerstaff E, Russell J, Zhang Z, Klingler S, Cho H, Kaag MG, Mazaheri Y, Rimner A, Manova-Todorova K, Epel B, Zatcky J, Cleary CR, Rao SS, Yamada Y, Zelefsky MJ, Halpern HJ, Koutcher JA, Cordon-Cardo C, Greco C, Haimovitz-Friedman A, Sala E, Powell SN, Kolesnick R, Fuks Z. Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. J Clin Invest 129(2):786-801, 2019. e-Pub 2019. PMID: 30480549.
- Han S, Stoyanova R, Lee H, Carlin SD, Koutcher JA, Cho H, Ackerstaff E. Automation of pattern recognition analysis of dynamic contrast-enhanced MRI data to characterize intratumoral vascular heterogeneity. Magn Reson Med 79(3):1736-1744, 2018. e-Pub 2018. PMID: 28727185.
- Chang YC, Ackerstaff E, Tschudi Y, Jimenez B, Foltz W, Fisher C, Lilge L, Cho H, Carlin S, Gillies RJ, Balagurunathan Y, Yechieli RL, Subhawong T, Turkbey B, Pollack A, Stoyanova R. Delineation of Tumor Habitats based on Dynamic Contrast Enhanced MRI. Sci Rep 7(1):9746, 2017. e-Pub 2017. PMID: 28851989.
- Simões RV, Veeraperumal S, Serganova IS, Kruchevsky N, Varshavsky J, Blasberg RG, Ackerstaff E, Koutcher JA. Inhibition of prostate cancer proliferation by Deferiprone. NMR Biomed 30(6), 2017. e-Pub 2017. PMID: 28272795.
- Patel BB, Ackerstaff E, Serganova IS, Kerrigan JE, Blasberg RG, Koutcher JA, Banerjee D. Tumor stroma interaction is mediated by monocarboxylate metabolism. Exp Cell Res 352(1):20-33, 2017. e-Pub 2017. PMID: 28132882.
- Sun X, Ackerstaff E, He F, Xing L, Hsiao HT, Koutcher JA, Ling CC, Li GC. Visualizing the antivascular effect of bortezomib on the hypoxic tumor microenvironment. Oncotarget 6(33):34732-44, 2015. e-Pub 2015. PMID: 26416246.
- Simões RV, Serganova IS, Kruchevsky N, Leftin A, Shestov AA, Thaler HT, Sukenick G, Locasale JW, Blasberg RG, Koutcher JA, Ackerstaff E. Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment. Neoplasia 17(8):671-84, 2015. e-Pub 2015. PMID: 26408259.
- Viola-Villegas NT, Carlin SD, Ackerstaff E, Sevak KK, Divilov V, Serganova I, Kruchevsky N, Anderson M, Blasberg RG, Andreev OA, Engelman DM, Koutcher JA, Reshetnyak YK, Lewis JS. Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc Natl Acad Sci U S A 111(20):7254-9, 2014. e-Pub 2014. PMID: 24785505.
- Pu Y, Xue J, Wang W, Xu B, Gu Y, Tang R, Ackerstaff E, Koutcher JA, Achilefu S, Alfano RR. Native fluorescence spectroscopy reveals spectral differences among prostate cancer cell lines with different risk levels. J Biomed Opt 18(8):87002, 2013. e-Pub 2013. PMID: 23912761.
- Xing L, Sun X, Deng X, Kotedia K, Zanzonico PB, Ackerstaff E, Koutcher JA, Ling CC, Li GC. A triple suicide gene strategy that improves therapeutic effects and incorporates multimodality molecular imaging for monitoring gene functions. Cancer Gene Ther 20(6):358-65, 2013. e-Pub 2013. PMID: 23722591.
- Han SH, Ackerstaff E, Stoyanova R, Carlin S, Huang W, Koutcher JA, Kim JK, Cho G, Jang G, Cho H. Gaussian mixture model-based classification of dynamic contrast enhanced MRI data for identifying diverse tumor microenvironments: preliminary results. NMR Biomed 26(5):519-32, 2013. e-Pub 2013. PMID: 23440683.
- Pu Y, Xue J, Xu B, Wang W, Gu Y, Tang R, Achilefu S, Ackerstaff E, Koutcher JA, Alfano R. Investigation of native fluorescence spectral difference among prostate cancer cell lines with different risk levels. Proc. SPIE 8577(Optical Biopsy XI):85770X, 2013. e-Pub 2013.
- Stoyanova R, Huang K, Sandler K, Cho H, Carlin S, Zanzonico PB, Koutcher JA, Ackerstaff E. Mapping Tumor Hypoxia In Vivo Using Pattern Recognition of Dynamic Contrast-enhanced MRI Data. Transl Oncol 5(6):437-47, 2012. e-Pub 2012. PMID: 23326621.
- Han S, Paulsen JL, Zhu G, Song Y, Chun S, Cho G, Ackerstaff E, Koutcher JA, Cho H. Temporal/spatial resolution improvement of in vivo DCE-MRI with compressed sensing-optimized FLASH. Magn Reson Imaging 30(6):741-52, 2012. e-Pub 2012. PMID: 22465192.
- Rattigan YI, Patel BB, Ackerstaff E, Sukenick G, Koutcher JA, Glod JW, Banerjee D. Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. Exp Cell Res 318(4):326-35, 2012. e-Pub 2012. PMID: 22178238.
- Darpolor MM, Kennealey PT, Le HC, Zakian KL, Ackerstaff E, Rizwan A, Chen JH, Sambol EB, Schwartz GK, Singer S, Koutcher JA. Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS. NMR Biomed 24(9):1159-68, 2011. e-Pub 2011. PMID: 21994185.
- Suehiro M, Yang G, Torchon G, Ackerstaff E, Humm J, Koutcher J, Ouerfelli O. Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles. Bioorg Med Chem 19(7):2287-97, 2011. e-Pub 2011. PMID: 21398131.
- Kakkad SM, Solaiyappan M, O'Rourke B, Stasinopoulos I, Ackerstaff E, Raman V, Bhujwalla ZM, Glunde K. Hypoxic tumor microenvironments reduce collagen I fiber density. Neoplasia 12(8):608-17, 2010. e-Pub 2010. PMID: 20689755.
- Shah T, Wildes F, Penet MF, Winnard PT, Glunde K, Artemov D, Ackerstaff E, Gimi B, Kakkad S, Raman V, Bhujwalla ZM. Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells. NMR Biomed 23(6):633-42, 2010. e-Pub 2010. PMID: 20623626.
- Cho H, Ackerstaff E, Carlin S, Lupu ME, Wang Y, Rizwan A, O’Donoghue J, Ling C, Humm JL, Zanzonico PB, Koutcher JA. Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia. Neoplasia 11(3):247-59, 2p following 259, 2009. e-Pub 2009. PMID: 19242606.
- Xing L, Deng X, Kotedia K, Ackerstaff E, Ponomarev V, Clifton Ling C, Koutcher JA, Li GC. Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein. Acta Oncol 47(7):1211-20, 2008. e-Pub 2008. PMID: 18661431.
- Ackerstaff E, Artemov D, Gillies RJ, Bhujwalla ZM. Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism. Neoplasia 9(12):1138-51, 2007. e-Pub 2007. PMID: 18084621.
- Ackerstaff E, Gimi B, Artemov D, Bhujwalla ZM. Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line. Neoplasia 9(3):222-35, 2007. e-Pub 2007. PMID: 17401462.
- Gimi B, Mori N, Ackerstaff E, Frost EE, Bulte JW, Bhujwalla ZM. Noninvasive MRI of endothelial cell response to human breast cancer cells. Neoplasia 8(3):207-13, 2006. e-Pub 2006. PMID: 16611414.
- Glunde K, Ackerstaff E, Natarajan K, Artemov D, Bhujwalla ZM. Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin. Magn Reson Med 48(5):819-25, 2002. e-Pub 2002. PMID: 12417996.
- Pilatus U, Aboagye E, Artemov D, Mori N, Ackerstaff E, Bhujwalla ZM. Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy. Magn Reson Med 45(5):749-55, 2001. e-Pub 2001. PMID: 11323800.
- Ackerstaff E, Pflug BR, Nelson JB, Bhujwalla ZM. Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. Cancer Res 61(9):3599-603, 2001. e-Pub 2001. PMID: 11325827.
- Bhujwalla ZM, Artemov D, Natarajan K, Ackerstaff E, Solaiyappan M. Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts. Neoplasia 3(2):143-53, 2001. e-Pub 2001. PMID: 11420750.
- Pilatus U, Ackerstaff E, Artemov D, Mori N, Gillies RJ, Bhujwalla ZM. Imaging prostate cancer invasion with multi-nuclear magnetic resonance methods: the Metabolic Boyden Chamber. Neoplasia 2(3):273-9, 2000. e-Pub 2000. PMID: 10935513.
Review Articles
- Ramamonjisoa N, Ackerstaff E. Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging. Front Oncol 7:3, 2017. e-Pub 2017. PMID: 28197395.
- Bokacheva L, Ackerstaff E, LeKaye HC, Zakian K, Koutcher JA. High-field small animal magnetic resonance oncology studies. Phys Med Biol 59(2):R65-R127, 2014. e-Pub 2014. PMID: 24374985.
- Zakian KL, Shukla-Dave A, Ackerstaff E, Hricak H, Koutcher JA. 1H magnetic resonance spectroscopy of prostate cancer: biomarkers for tumor characterization. Cancer Biomark 4(4-5):263-76, 2008. e-Pub 2008. PMID: 18957715.
- Glunde K, Ackerstaff E, Mori N, Jacobs MA, Bhujwalla ZM. Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions. Mol Pharm 3(5):496-506, 2006. e-Pub 2006. PMID: 17009848.
- Gimi B, Pathak AP, Ackerstaff E, Glunde K, Artemov D, Bhujwalla ZM. Molecular Imaging of Cancer: Applications of Magnetic Resonance Methods. Proc IEEE Inst Electr Electron Eng 93(4):784-799, 2005. e-Pub 2005. PMID: 19779604.
- Pathak AP, Gimi B, Glunde K, Ackerstaff E, Artemov D, Bhujwalla ZM. Molecular and functional imaging of cancer: advances in MRI and MRS. Methods Enzymol 386:3-60, 2004. e-Pub 2004. PMID: 15120245.
- Ackerstaff E, Glunde K, Bhujwalla ZM. Choline phospholipid metabolism: a target in cancer cells?. J Cell Biochem 90(3):525-33, 2003. e-Pub 2003. PMID: 14523987.
- Bhujwalla ZM, Artemov D, Aboagye E, Ackerstaff E, Gillies RJ, Natarajan K, Solaiyappan M. The physiological environment in cancer vascularization, invasion and metastasis. Novartis Found Symp 240:23-38; discussion 38-45, 152-3, 2001. e-Pub 2001. PMID: 11727932.
Professional Educational Materials
- Ackerstaff E. Redesigned & improved curriculum for laboratory course Physics 1 (Mechanics & Optics).
- Ackerstaff E. Developed & Designed Biophysics Syllabus.
Other Articles
- Cho H, Ackerstaff E, Carlin S, Lupu ME, Wang Y, Rizwan A, O'Donoghue J, Ling CC, Humm JL, Zanzonico PB, Koutcher JA Corrigendum to "Noninvasive Multimodality Imaging of the Tumor Microenvironment: Registered Dynamic Magnetic Resonance Imaging and Positron Emission Tomography Studies of a Preclinical Tumor Model of Tumor Hypoxia" [Neoplasia 11 (2009) 247-259]. Neoplasia 18(12):811, 2016. PMID: 27978998.
Editorials
- Ackerstaff E, López-Larrubia P. Editorial: Differentiating brain cancers and glioblastoma through imaging methodologies. Front Oncol 13:1351874, 2023. PMID: 38164194.
Abstracts
- Ravi H, Damodar N, Healey D, Ackerstaff E, Gumin J, Lang FF, Shpall EJ, Vilchez MCM, Wang SJ, Quarles CC. BIOM-45. ON THE DEVELOPMENT OF A CLINICALLY FEASIBLE PROTOCOL FOR LABELING MESENCHYMAL STEM CELLS WITH IRON OXIDE PARTICLES AND ONCOLYTIC VIRUS: A PILOT STUDY. Neuro Oncol 27(Supplement_5):v34-v34, 2025. e-Pub 2025.
- Ravi H, Damodar N, Healey D, Ackerstaff E, Gumin J, Lang FF, Shpall EJ, Vilchez MCM, Wang SJ, Quarles CC. BIOM-46. MRI RELAXATION PARAMETERS COULD REVEAL INFORMATION ON INTACT IRON OXIDE PARTICLES LABELED MESENCHYMAL STEM CELLS. Neuro Oncol 27(Supplement_5):v35-v35, 2025. e-Pub 2025.
- Jang HJ, Li Z, Li YJ, Bagheri P, Ackerstaff E, Koutcher JA, Shi L. Super-resolution non-linear multimodal imaging platform for studying spatially correlated metabolic reactions. Biophys J 122(3 Supplement 1):133A-133A, 2023. e-Pub 2023.
- Ackerstaff E, Budhu S, Winkleman DP, Min S, Ijoma JN, Serganova IS, Blasberg RG, Merghoub T, Koutcher JA. Deferiprone alters macrophage function and metabolism. Cancer Res 82(12 Supplement 5):LB135, 2022. e-Pub 2022.
- Zappasodi R, Serganova I, Cohen I, Maeda M, Senbabaoglu Y, Shindo M, Maniyar R, Mane M, Leftin A, Watson M, Verma S, Lubin M, Ko MK, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher J, Ho P, Delgoffe G, Blasberg R, Wolchok J, Merghoub T. 254 CTLA-4 blockade promotes Treg glucose metabolism and reduces Treg functional stability in glycolysis-defective tumors. J Immunother Cancer 8(Supplement 3):A153-A154, 2020. e-Pub 2020.
- Zappasodi R, Serganova I, Cohen I, Maeda M, Shindo M, Senbabaoglu Y, Leftin A, Maniyar R, Verma S, Lubin M, Ko MK, Mane MM, Ghosh A, Ackerstaff E, Koutcher JA, Ho P, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. Abstract 3257: CTLA-4 blockade drives loss of regulatory T cell functional stability in glycolysis defective tumors. Cancer Res 80(16_Supplement):3257, 2020. e-Pub 2020.
- Mane MM, Shalaby K, Cohen I, Albeg A, Ijoma J, Ko M, Maeda M, Vemuri K, Satagopan J, Moroz A, Zurita J, Shenker L, Ackerstaff E, Shindo M, Moroz E, Moroz MA, Serganova I, Koutcher J, Ponomarev V, Blasberg RG. Abstract A089: The effect of lactate dehydrogenase-A (LDH-A) knockdown and human prostate-specific membrane antigen (hPSMA) directed CAR T cell treatment on hPSMA(+) Myc-CaP tumors. Cancer Immunol Res 7(2_Supplement):A089, 2019. e-Pub 2019.
- Zappasodi R, Ghosh A, Serganova I, Cohen I, Senbabaoglu Y, Shindo M, Mane MM, Leftin A, Ackerstaff E, Koutcher JA, Wolchok JD, Blasberg RG, Merghoub T. Abstract PR06: Overcoming intratumor T-cell exclusion by modulation of lactate metabolism to improve immune checkpoint therapies in aggressive breast cancer. Cancer Immunol Res 4(11_Supplement):PR06, 2016. e-Pub 2016.
- Chang Y, Solorzano G, Ackerstaff E, Yechieli R, Subhawong T, Stoyanova R. SU-F-R-16: Delineation of Tumor Habitats Based On Dynamic Contrast Enhanced MRI. Med Phys 43(6):3376-3376, 2016. e-Pub 2016.
- Campagne CG, Thin TH, Fuller JD, Ackerstaff E, Koutcher JA, Haimovitz-Friedman A, Powell SN, Kolesnick RN, Fuks Z. Abstract LB-215: Epigenetic loss-of-function BRCA1 mediates tumor cure by single dose radiotherapy. Cancer Res 75(15_Supplement):LB-215, 2015. e-Pub 2015.
- Simoes RV, Ackerstaff E, Serganova I, Kruchevsky N, Sukenick G, Blasberg R, Koutcher JA. Metastatic and Non−Metastatic Isogenic Breast Cancer Cells Lines Show Different Metabolic Signatures in Response to Intermittent Hypoxia and Transient Glutamine/Glucose Deprivation. Cancer Res 72(24_Supplement):P6-01-01, 2012. e-Pub 2012.
- Patel B, Rattigan Y, Ackerstaff E, Koutcher J, Sukenick G, Glod J, Banerjee D. Adaptive exploitation of stromal cell metabolism by tumor cells. FASEB J 26(S1):966.5, 2012. e-Pub 2012.
- Patel B, Rattigan Y, Ackerstaff E, Koutcher J, Sukenick G, Glod J, Banerjee D. P1-03-03: Adaptive exploitation of stromal cell metabolism by tumor cells. Cancer Res 74(24_Supplement):P1-03-03, 2011. e-Pub 2011.
- Patel B, Rattigan YI, Ackerstaff E, Sukenick G, Glod JW, Banerjee D. 1064 POSTER : Adaptive exploitation of stromal cell metabolism by tumor cells. Eur J Cancer 47(Supplement 1):S114 - S114, 2011. e-Pub 2011.
- Patel BB, Rattigan YI, Ackerstaff E, Sukenick G, Glod JW, Koutcher J, Banerjee D. Abstract LB-287: Adaptive exploitation of stromal cell metabolism by tumor cells. Cancer Res 71(Supplement 8):LB-287, 2011. e-Pub 2011.
- Stoyanova R, Ackerstaff E, Cho H, Koutcher JA, Pollack A. Poster 2300: DCE-MRI for Delineation of Hypoxic Regions in Prostate Tumor. Int J Radiat Oncol Biol Phys 78(3 Supplement):S337, 2010. e-Pub 2010.
- He F, Sun X, Ackerstaff E, Xing L, Minami A, Hsiao HT, Carlin S, Ling CC, Koutcher J, Li GC. Poster 1381: The effect of proteasome inhibitor velcade on tumor microenvironment. Cancer Res 70(8_Suppl):1381, 2010. e-Pub 2010.
- Ackerstaff E, Cho H, Carlin S, Rizwan A, Suehiro M, Ouerfelli O, Zanzonico PB, Humm JL, Koutcher JA. Hypoxia Imaging in Cancer – Preclinical Studies. Advanced BioTech 10(5):80, 2010. e-Pub 2010.
- Sun X, He F, Ackerstaff E, Xing L, Minami A, Carlin S, Ling C, Koutcher J, Li G. Poster Discussion 1100: The Effect of Proteasome Inhibitor Velcade on Tumor Microenvironment. Int J Radiat Oncol Biol Phys 75(3 Suppl):S171-S171, 2009. e-Pub 2009.
- Suehiro M, Ouerfelli O, Torchon G, Koziorowski J, Humm J, Ackerstaff E, Koutcher J. Approaches Towards Radiolabeling of Trifluoro-Miso with 18F. J. Labelled Comp. Radiopharm 52(S1):S3, 2009. e-Pub 2009.
- Ackerstaff E, Wildes F, Raman V, Artemov D, Bhujwalla ZM. Abstract ID 270: Human Prostate Cancer Cells Overexpressing VEGF Exhibit Increased Invasion and Metabolic Changes under Hypoxia in the Presence of Endothelial Cells. Molecular Imaging 3(3):251, 2004. e-Pub 2004.
- Gimi B, Mori N, Ackerstaff E, Frost EE, M Bulte JW, Bhujwalla ZM. Abstract ID 279: MR Imaging Of Superparamagnetically Labeled Endothelial Cells Revealed Directed Migration In Response To Factors Secreted By Human Breast Cancer Cells. Molecular Imaging 3(3):254, 2004. e-Pub 2004.
- Bhujwalla ZM, Solaiyappan M, Pathak AP, Ackerstaff E, Raman V, Glunde K, Artemov D. Abstract ID 072: Characterizing Tumors with Multi-Modality Imaging. Molecular Imaging 3(3):196, 2004. e-Pub 2004.
- Ackerstaff E, Mironchik Y, Raman V, Artemov D, Bhujwalla ZM. Abstract ID 335: VEGF Overexpressing Human Prostate Cancer Cells Exhibit Increased Invasion. Molecular Imaging 2(3):273, 2003. e-Pub 2003.
- Ackerstaff E, Artemov D, Gillies R, Bhujwalla Z. Abstract ID 170: Endothelial Cells Promote Invasion of the Human Prostate Cancer Cell Line PC-3 under Hypoxia. Molecular Imaging 1(3):204, 2002. e-Pub 2002.
- Fichtner A, Luebberstedt H, Ackerstaff E, Mayer A. P-H4-09: Diffusion-weighted 1H nmr studies of the microalgae Chlorella fusca. Prog Biophys Mol Biol 65(Supplement 1):PH409, 1996. e-Pub 1996.
Book Chapters
- Jacobs MA, Glunde K, Gimi B, Pathak AP, Ackerstaff E, Artemov D, Bhujwalla ZM. Chapter 8: MR Molecular and Functional Imaging of Cancer. In: Molecular and Cellular MR Imaging. 1st Edition. Taylor & Francis CRC Press, 141-160, 2007.
- Bhujwalla ZM, Glunde K, Ackerstaff E, Pathak AP, Gimi B, Mori N, Raman V, Artemov D. Chapter 13: Functional and Molecular MRI of Preclinical Cancer Models in Drug Discovery and Development. In: In vivo MR techniques in drug discovery and development. 1st Edition. Taylor & Francis CRC Press, 255-279, 2006.
- Bhujwalla ZM, Artemov D, Ackerstaff E, Solaiyappan M, Glunde K, Pathak AP, Raman V. Chapter 19: In Vivo Cellular and Molecular Imaging of Cancer. In: Biomedical Magnetic Resonance: Proceedings of the International Workshop. 1st Edition. Jaypee Brothers Medical Publishers (P) Ltd, 247-256, 2005.
- Bhujwalla ZM, Artemov D, Ackerstaff E, Mayappan S. Chapter 12: MRI and MRS Studies of Cancer. In: Recent Advances in MR Imaging and Spectroscopy in Experimental and Clinical Research. 1st Edition. Jaypee Brothers Medical Publishers (P) Ltd, 262-280, 2005.
Books (edited and written)
- Ackerstaff E. In vivo 13C-, 15N-, 31P- und diffusionsgewichtete 1H-Kernspinresonanzspektroskopie - Untersuchungen zum Stoffwechsel und zur Wasserdiffusion in der photoautotrophen Mikroalge Chlorella fusca. Logos Verlag, 1998.
Patient Reviews
CV information above last modified August 11, 2026