Enoch Chang, MD
Department of GI Radiation Oncology, Division of Radiation Oncology
About Dr. Enoch Chang
Dr. Enoch Chang is an Assistant Professor of Gastrointestinal Radiation Oncology at MD Anderson. He received his BA from Yale University and his MD, cum laude, from Yale School of Medicine, followed by residency at MD Anderson.
The MD Anderson Department of GI Radiation Oncology represents decades of GI cancer expertise by nine radiation oncology doctors, and a specialized team of GI radiotherapy physician assistants, nurses, physicists, therapists, and dosimetrists. We treat cancers of the stomach, liver, bile duct, pancreas, rectum, and anus. We offer every type of radiotherapy technology including intensity modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT), and proton therapy, always selected and personalized for each patient. We are constantly working to improve radiotherapy for GI cancers, and offer many clinical trials designed to make radiotherapy more effective with fewer side effects.
Present Title & Affiliation
Primary Appointment
Assistant Professor, Gastrointestinal Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2021 | Yale School of Medicine, New Haven, Connecticut, US, MD |
| 2016 | Yale University, New Haven, Connecticut, US, BA in Philosophy |
Postgraduate Training
| 2024-2025 | Fellow, Institute for Data Science in Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2022-2026 | Clinical Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2021-2022 | Clinical Internship, Internal Medicine, California Pacific Medical Center, San Francisco, California |
Licenses & Certifications
| 2026 | DEA |
| 2026 | Texas Medical Board |
Experience & Service
Intramural Institutional Committee Activities
Member, Radiation Oncology Residency Interview Committee, The University of Texas MD Anderson Cancer Center, 2025 - Present
Resident Representative, Clinical Effectiveness Advisory Committee, The University of Texas MD Anderson Cancer Center, 2024 - 2025
Resident Representative, Radiation Oncology Clinical Operations Committee, The University of Texas MD Anderson Cancer Center, 2023 - 2024
Extramural Institutional Committee Activities
Resident Representative, Gastrointestinal Committee, SWOG, 2025 - 2026
Honors & Awards
| 2025 | Resident Educator of the Year, The University of Texas MD Anderson Cancer Center |
| 2024 | Mary Fletcher Memorial Award for Clinical Excellence and Compassionate Patient Care, The University of Texas MD Anderson Cancer Center |
| 2021 | Louis G. Welt Prize for an Outstanding Thesis, Yale School of Medicine |
| 2021 | Cum Laude, Yale School of Medicine |
| 2020 | Research Medical Student Grant, Radiological Society of North America |
| 2020 | Award for Excellence in Neuro-Imaging, Society for Neuro-Oncology |
Professional Memberships
Selected Presentations & Talks
National Presentations
- 2023. Phase I Trial of SPECT-Guided Liver-Directed Ablative Radiotherapy for Patients with Low Functional Liver Volume. ASTRO Annual Meeting. San Diego, California, US.
- 2021. Machine Learning Methods for Survival Analysis. NRG Oncology Digital Health Workshop, US.
- 2020. Deep Learning Survival Analysis for Multiple Brain Metastases. SNO Annual Meeting, US.
- 2020. Deep Learning Survival Analysis for Brain Metastases Treated with Stereotactic Radiosurgery. ASTRO Annual Meeting, US.
Selected Publications
Peer-Reviewed Articles
- Chang E, Holliday EB, Szklaruk J, Erwin WD, Ludmir EB, Noticewala SS, Das P, Koong AC, Minsky BD, Smith GL, Sawakuchi GO, Martin-Paulpeter RM, Niedzielski JS, Perles LA, Beddar S, Valino VS, Nguyen JL, Raghav KPS, Javle M, Kaseb AO, Dasari AN, Overman MJ, Parseghian CM, Odisio BC, Mahvash A, Kuban JD, Shen SE, Wang XS, Gupta AC, Al Taie MM, Brock KK, Tzeng CD, Vauthey JN, Wong FCL, Koay EJ. Single-photon emission computed tomography functional liver imaging to facilitate reirradiation for liver malignancies: A phase I trial. JHEP Rep 8(4):101743, 2026. e-Pub 2026. PMID: 41825097.
- De B, Dogra P, Zaid M, Elganainy D, Sun K, Amer AM, Wang C, Rooney MK, Chang E, Kang HC, Wang Z, Bhosale P, Odisio BC, Newhook TE, Tzeng CD, Tran Cao HS, Chun YS, Vauthey JN, Lee SS, Kaseb A, Raghav K, Javle M, Minsky BD, Noticewala SS, Holliday EB, Smith GL, Koong AC, Das P, Cristini V, Ludmir EB, Koay EJ. Measurable imaging-based changes in enhancement of intrahepatic cholangiocarcinoma after radiotherapy reflect physical mechanisms of response. NPJ Syst Biol Appl 11(1):140, 2025. e-Pub 2025. PMID: 41387975.
- Grippin AJ, Marconi C, Copling S, Li N, Braun C, Woody C, Young E, Gupta P, Wang M, Wu A, Jeong SD, Soni D, Weidert F, Xie C, Goldenberg E, Kim A, Zhao C, DeVries A, Castillo P, Lohray R, Rooney MK, Schrank BR, Wang Y, Ma Y, Chang E, Kouzy R, Dyson K, Jafarnia J, Nariman N, Gladish G, New J, Argueta A, Amaya D, Thomas N, Doty A, Chen J, Copling N, Alatrash G, Simon J, Davies AB, Dennis W, Liang R, Lewis J, Wei X, Rinsurongkawong W, Vaporciyan AA, Johns A, Lee J, Lee JH, Sun R, Sharma P, Tran H, Zhang J, Gibbons DL, Wargo J, Kim BYS, Heymach JV, Mendez-Gomez HR, Jiang W, Sayour EJ, Lin SH. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. Nature 647(8089):488-497, 2025. e-Pub 2025. PMID: 41125896.
- Asif A, Asif A, Rooney MK, Chang E, Namayanja F, Quentin K, Lee S, Hu I, Bernard V, Das P, Holiday EB, Noticewala S, Smith GL, Koong AC, Ludmir EB, Javle M, Xiao L, Koay EJ. Safety and efficacy of liver-directed radiotherapy after chemoimmunotherapy for advanced cholangiocarcinoma: an early report from a large tertiary cancer center. J Gastrointest Oncol 16(5):2146-2157, 2025. e-Pub 2025. PMID: 41220722.
- Sperduto PW, Marqueen KE, Chang E, Li J, Davies MA, Ebner DK, Breen WG, Lamba N, Shih HA, Edwards D, Kim MM, Mahal A, Rahman R, Ankrah N, Boggs DH, Lewis C, Hyer D, Buatti JM, Johri F, Soliman H, Masucci L, Roberge D, Aneja S, Chiang V, Phuong C, Braunstein S, Dajani S, Sachdev S, Wan Z, Niedzwiecki D, Vaios E, Kirkpatrick JP, Pasetsky J, Wang TJC, Kutuk T, Kotecha R, Ross RB, Rusthoven CG, Nakano T, Tawbi HA, Mehta MP. Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment. J Clin Oncol 43(16):1910-1919, 2025. e-Pub 2025. PMID: 40245362.
- Wahid KA, Dede C, El-Habashy DM, Kamel S, Rooney MK, Khamis Y, Abdelaal MRA, Ahmed S, Corrigan KL, Chang E, Dudzinski SO, Salzillo TC, McDonald BA, Mulder SL, McCullum L, Alakayleh Q, Sjogreen C, He R, Mohamed ASR, Lai SY, Christodouleas JP, Schaefer AJ, Naser MA, Fuller CD. Overview of the Head and Neck Tumor Segmentation for Magnetic Resonance Guided Applications (HNTS-MRG) 2024 Challenge. Head Neck Tumor Segm MR Guid Appl (2024) 15273:1-35, 2025. e-Pub 2025. PMID: 40115167.
- Chang E, Wong FCL, Chasen BA, Erwin WD, Das P, Holliday EB, Koong AC, Ludmir EB, Minsky BD, Noticewala SS, Smith GL, Taniguchi CM, Rodriguez MJ, Beddar S, Martin-Paulpeter RM, Niedzielski JS, Sawakuchi GO, Schueler E, Perles LA, Xiao L, Szklaruk J, Park PC, Dasari AN, Kaseb AO, Kee BK, Lee SS, Overman MJ, Willis JA, Wolff RA, Tzeng CD, Vauthey JN, Koay EJ. Phase I trial of single-photon emission computed tomography-guided liver-directed radiotherapy for patients with low functional liver volume. JNCI Cancer Spectr 8(3), 2024. e-Pub 2024. PMID: 38730548.
- Arzola A, Chang E, Rooney MK, Corrigan K, Das P, Ludmir EB, Koay EJ, Minsky BD, Smith GL, Messick C, Morris VK, Nebgen D, Crane CH, Holliday EB. Daily Vaginal Dilator Use During Radiation for Women With Squamous Cell Carcinoma of the Anus: Vaginal Wall Dosimetry and Patient-Reported Sexual Function. Pract Radiat Oncol 14(2):e105-e116, 2024. e-Pub 2024. PMID: 37898354.
- Joel MZ, Umrao S, Chang E, Choi R, Yang DX, Duncan JS, Omuro A, Herbst R, Krumholz HM, Aneja S. Using Adversarial Images to Assess the Robustness of Deep Learning Models Trained on Diagnostic Images in Oncology. JCO Clin Cancer Inform 6:e2100170, 2022. e-Pub 2022. PMID: 35271304.
- Khullar D, Casalino LP, Qian Y, Lu Y, Chang E, Aneja S. Public vs physician views of liability for artificial intelligence in health care. J Am Med Inform Assoc 28(7):1574-1577, 2021. e-Pub 2021. PMID: 33871009.
- Chang E, Joel MZ, Chang HY, Du J, Khanna O, Omuro A, Chiang V, Aneja S. Comparison of radiomic feature aggregation methods for patients with multiple tumors. Sci Rep 11(1):9758, 2021. e-Pub 2021. PMID: 33963236.
- Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Netw Open 4(3):e211793, 2021. e-Pub 2021. PMID: 33755165.
- Chang E, Mougalian SS, Adelson KB, Young MR, Yu JB. Association between prolonged metastatic free interval and recurrent metastatic breast cancer survival: findings from the SEER database. Breast Cancer Res Treat 173(1):209-216, 2019. e-Pub 2019. PMID: 30242577.
Review Articles
- Chang E, Sherry AD, Liermann J, Abdollahi A, Tzeng CD, Tang C, Aguilera TA, Koay EJ, Das P, Koong AC, Pant S, Ludmir EB. Evolving Paradigms in the Treatment of Oligometastatic Pancreatic Ductal Adenocarcinoma. J Gastrointest Cancer 56(1):47, 2025. e-Pub 2025. PMID: 39827280.
- Aneja S, Chang E, Omuro A. Applications of artificial intelligence in neuro-oncology. Curr Opin Neurol 32(6):850-856, 2019. e-Pub 2019. PMID: 31609739.
Book Chapters
- Chang E, Zaorsky NG, Park HS. Systematic Reviews and Meta-Analyses. In: Principles of Clinical Cancer Research. Springer Publishing, 2018.
Patient Reviews
CV information above last modified September 25, 2026