Gamze Bildik Elcik

Peer-Reviewed Articles

1. Bildik G, Gray JP, Mao W, Yang H, Ozyurt R, Orellana VR, De Wever O, Carey MS, Bast RC, Lu Z. DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas. Autophagy 20(3):675-691, 2024. e-Pub 2024. PMID: 38169324.
2. Esmaeilian Y, Yusufoglu S, Iltumur E, Bildik G, Oktem O. Visualizing Lipophagy as a New Mechanism of the Synthesis of Sex Steroids in Human Ovary and Testis Using Immunofluorescence Staining Method. Methods Mol Biol. e-Pub 2024. PMID: 38411886.
3. Liang X, Jung SY, Fong LW, Bildik G, Gray JP, Mao W, Zhang S, Millward SW, Gorfe AA, Zhou Y, Lu Z, Bast RC. Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function. iScience 26(11):108151, 2023. e-Pub 2023. PMID: 37915607.
4. Esmaeilian Y, Hela F, Bildik G, Iltumur E, Yusufoglu S, Yildiz CS, Yakin K, Kordan Y, Oktem O. Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis. Cell Death Dis 14(5):342, 2023. e-Pub 2023. PMID: 37236920.
5. Yildiz S, Bildik G, Benlioglu C, Turan V, Dilege E, Ozel M, Kim S, Oktem O. Breast cancer treatment and ovarian function. Reprod Biomed Online 46(2):313-331, 2023. e-Pub 2022. PMID: 36400663.
6. Timofeeva N, Ayres ML, Baran N, Santiago-O'Farrill JM, Bildik G, Lu Z, Konopleva M, Gandhi V. Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia. Front Oncol 13:1161254, 2023. e-Pub 2023. PMID: 37228498.
7. Esmaeilian Y, Hela F, Bildik G, Akin N, Iltumur E, Yusufoglu S, Yildiz CS, Keles I, Vatansever D, Taskiran C, Yakin K, Oktem O. IVF characteristics and the molecular luteal features of random start IVF cycles are not different from conventional cycles in cancer patients. Hum Reprod 38(1):113-124, 2023. PMID: 36367834.
8. Bildik G, Esmaeilian Y, Hela F, Akin N, Iltumur E, Yusufoglu S, Yildiz CS, Yakin K, Oktem O. Cholesterol uptake or trafficking, steroid biosynthesis, and gonadotropin responsiveness are defective in young poor responders. Fertil Steril 117(5):1069-1080, 2022. e-Pub 2022. PMID: 35292154.
9. Bildik G, Liang X, Sutton MN, Bast RC, Lu Z. DIRAS3: An Imprinted Tumor Suppressor Gene that Regulates RAS and PI3K-driven Cancer Growth, Motility, Autophagy, and Tumor Dormancy. Mol Cancer Ther 21(1):25-37, 2022. e-Pub 2021. PMID: 34667114.
10. Vatansever D, Incir S, Bildik G, Taskiran C, Oktem O. In-vitro AMH production of ovarian tissue samples in culture correlates with their primordial follicle pool. Eur J Obstet Gynecol Reprod Biol 254:138-140, 2020. e-Pub 2020. PMID: 32971433.
11. Bildik G, Esmaeilian Y, Vatansever D, Bilir E, Taskiran C, Oktem O. A comparative molecular analysis of DNA damage response, cell cycle progression, viability and apoptosis of malignant granulosa cells exposed to gemcitabine and cisplatin. Mol Biol Rep 47(5):3789-3796, 2020. e-Pub 2020. PMID: 32277442.
12. Bildik G, Akin N, Esmaeilian Y, Hela F, Yakin K, Onder T, Urman B, Oktem O. hCG Improves Luteal Function and Promotes Progesterone Output through the Activation of JNK Pathway in the Luteal Granulosa Cells of the Stimulated IVF Cycles†. Biol Reprod 102(6):1270-1280, 2020. PMID: 32163131.
13. Bildik G, Akin N, Esmaeilian Y, Hela F, Yildiz CS, Iltumur E, Incir S, Karahuseyinoglu S, Yakin K, Oktem O. Terminal differentiation of human granulosa cells as luteinization is reversed by activin-A through silencing of Jnk pathway. Cell Death Discov 6(1):93, 2020. e-Pub 2020. PMID: 33042587.
14. Güralp O, Bese T, Bildik G, Demikiran F, Ince Ü, Malik E, Arvas M, Öktem Ö. The mammalian target of rapamycin protein expression in human granulosa cell tumors. J Turk Ger Gynecol Assoc 20(4):247-254, 2019. e-Pub 2018. PMID: 30592193.
15. Bildik G, Akin N, Seyhan A, Esmaeilian Y, Yakin K, Keles I, Balaban B, Ata B, Urman B, Oktem O. Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles. Hum Reprod 34(2):345-355, 2019. PMID: 30520979.
16. Guzel Y, Bildik G, Dilege E, Oktem O. Sphingosine-1-phosphate reduces atresia of primordial follicles occurring during slow-freezing and thawing of human ovarian cortical strips. Mol Reprod Dev 85(11):858-864, 2018. e-Pub 2018. PMID: 29995320.
17. Bildik G, Acilan C, Sahin GN, Karahuseyinoglu S, Oktem O. C-Abl is not activated in DNA damage-induced and Tap63-mediated oocyte apoptosis in human ovary. Cell Death Dis 9(10):943, 2018. e-Pub 2018. PMID: 30237472.
18. Bildik G, Akin N, Senbabaoglu F, Esmalian Y, Sahin GN, Urman D, Karahuseyinoglu S, Ince U, Palaoglu E, Taskiran C, Arvas M, Guzel Y, Yakin K, Oktem O. Endogenous c-Jun N-terminal kinase (JNK) activity marks the boundary between normal and malignant granulosa cells. Cell Death Dis 9(4):421, 2018. e-Pub 2018. PMID: 29549247.
19. Guzel Y, Bildik G, Oktem O. Sphingosine-1-phosphate protects human ovarian follicles from apoptosis in vitro. Eur J Obstet Gynecol Reprod Biol 222:19-24, 2018. e-Pub 2018. PMID: 29331755.
20. Oktem O, Akin N, Bildik G, Yakin K, Alper E, Balaban B, Urman B. FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization. Hum Reprod 32(3):643-652, 2017. PMID: 28158500.
21. Oktem O, Bildik G, Senbabaoglu F, Lack NA, Akin N, Yakar F, Urman D, Guzel Y, Balaban B, Iwase A, Urman B. Cytotoxicity and mitogenicity assays with real-time and label-free monitoring of human granulosa cells with an impedance-based signal processing technology intergrating micro-electronics and cell biology. Reprod Toxicol 60:82-91, 2016. e-Pub 2015. PMID: 26746109.
22. Bildik G, Akin N, Senbabaoglu F, Sahin GN, Karahuseyinoglu S, Ince U, Taskiran C, Selek U, Yakin K, Guzel Y, Ayhan C, Alper E, Cetiner M, Balaban B, Mandel NM, Esen T, Iwase A, Urman B, Oktem O. GnRH agonist leuprolide acetate does not confer any protection against ovarian damage induced by chemotherapy and radiation in vitro. Hum Reprod 30(12):2912-25, 2015. e-Pub 2015. PMID: 26466909.
23. Yuksel A, Bildik G, Senbabaoglu F, Akin N, Arvas M, Unal F, Kilic Y, Karanfil I, Eryilmaz B, Yilmaz P, Ozkanbas C, Taskiran C, Aksoy S, Guzel Y, Balaban B, Ince U, Iwase A, Urman B, Oktem O. The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells. Hum Reprod 30(12):2926-35, 2015. e-Pub 2015. PMID: 26466914.