Guoyu Yu

Peer-Reviewed Articles

1. Yu G, Corn PG, Mak CSL, Liang X, Zhang M, Troncoso P, Song JH, Lin SC, Song X, Liu J, Zhang J, Logothetis CJ, Melancon MP, Panaretakis T, Wang G, Lin SH. Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization. Proc Natl Acad Sci U S A 121(33):e2402903121, 2024. e-Pub 2024. PMID: 39102549.
2. Lin, SC, Yu, G, Corn, P, Damasco, J, Lee, Y, Song, J, Navone, NM, Logothetis, CJ, Melancon, MP, Panaretakis, T, Lin, S. Radium-223 Treatment Produces Prolonged Suppression of Resident Osteoblasts and Decreased Bone Mineral Density in Trabecular Bone in Osteoblast Reporter Mice. Cancers 16(14), 2024. e-Pub 2024. PMID: 39061241.
3. Damasco, J, Yu, G, Kumar, A, Perez, JD, Lirag, RM, Whitley, EM, Lin, S, Melancon, MP. Alendronate conjugate for targeted delivery to bone-forming prostate cancer. Talanta 256, 2023. e-Pub 2023. PMID: 36774896.
4. Lin, S, Yu, G, Lee, Y, Song, J, Song, X, Zhang, J, Panaretakis, T, Logothetis, CJ, Komatsu, Y, Yu-Lee, LY, Wang, G, Lin, S. Endothelial-to-osteoblast transition in normal mouse bone development. iScience 26(2), 2023. e-Pub 2023. PMID: 36798441.
5. Yu, G, Corn, P, Shen, PF, Song, J, Lee, Y, Lin, S, Pan, J, Agarwal, SK, Panaretakis, T, Pacifici, M, Logothetis, CJ, Yu-Lee, LY, Lin, S. Retinoic Acid Receptor Activation Reduces Metastatic Prostate Cancer Bone Lesions by Blocking the Endothelial-to-Osteoblast Transition. Cancer Research 82(17):3158-3171, 2022. e-Pub 2022. PMID: 35802768.
6. Lee YC, Lin SC, Yu G, Zhu M, Song JH, Rivera K, Pappin DJ, Logothetis CJ, Panaretakis T, Wang G, Yu-Lee LY, Lin SH. Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition. Oncogene 41(6):757-769, 2022. e-Pub 2022. PMID: 34845375.
7. Pan T, Lin SC, Lee YC, Yu G, Song JH, Pan J, Titus M, Satcher RL, Panaretakis T, Logothetis C, Yu-Lee LY, Lin SH. Statins reduce castration-induced bone marrow adiposity and prostate cancer progression in bone. Oncogene 40(27):4592-4603, 2021. e-Pub 2021. PMID: 34127814.
8. Vardaki I, Corn P, Gentile E, Song JH, Madan N, Hoang A, Parikh N, Guerra L, Lee YC, Lin SC, Yu G, Santos E, Melancon MP, Troncoso P, Navone N, Gallick GE, Efstathiou E, Subudhi SK, Lin SH, Logothetis CJ, Panaretakis T. Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment. Clin Cancer Res 27(11):3253-3264, 2021. e-Pub 2021. PMID: 33753455.
9. Yu G, Shen P, Lee YC, Pan J, Song JH, Pan T, Lin SC, Liang X, Wang G, Panaretakis T, Logothetis CJ, Gallick GE, Yu-Lee LY, Lin SH. Multiple pathways coordinating reprogramming of endothelial cells into osteoblasts by BMP4. iScience 24(4):102388, 2021. e-Pub 2021. PMID: 33981975.
10. Rojo RD, Perez JVD, Damasco JA, Yu G, Lin SC, Heralde FM, Novone NM, Santos EB, Lin SH, Melancon MP. Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice. Int J Hyperthermia 38(1):650-662, 2021. e-Pub 2021. PMID: 33882773.
11. Pan T, Martinez M, Hubka KM, Song JH, Lin SC, Yu G, Lee YC, Gallick GE, Tu SM, Harrington DA, Farach-Carson MC, Lin SH, Satcher RL. Cabozantinib Reverses Renal Cell Carcinoma-mediated Osteoblast Inhibition in Three-dimensional Coculture In Vitro and Reduces Bone Osteolysis In Vivo. Mol Cancer Ther 19(6):1266-1278, 2020. e-Pub 2020. PMID: 32220969.
12. Yu-Lee LY, Lee YC, Pan J, Lin SC, Pan T, Yu G, Hawke DH, Pan BF, Lin SH. Bone secreted factors induce cellular quiescence in prostate cancer cells. Sci Rep 9(1):18635, 2019. e-Pub 2019. PMID: 31819067.
13. Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, Lin SH. Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway. Cancer Res 78(11):2911-2924, 2018. e-Pub 2018. PMID: 29514796.
14. Yu G, Cheng CJ, Lin SC, Lee YC, Frigo DE, Yu-Lee LY, Gallick GE, Titus MA, Nutt LK, Lin SH. Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II. Cancer Res 78(10):2490-2502, 2018. e-Pub 2018. PMID: 29535221.
15. Pan T, Lin SC, Yu KJ, Yu G, Song JH, Lewis VO, Bird JE, Moon B, Lin PP, Tannir NM, Jonasch E, Wood CG, Gallick GE, Yu-Lee LY, Lin SH, Satcher RL. BIGH3 Promotes Osteolytic Lesions in Renal Cell Carcinoma Bone Metastasis by Inhibiting Osteoblast Differentiation. Neoplasia 20(1):32-43, 2018. e-Pub 2018. PMID: 29190493.
16. Yu KJ, Li JK, Lee YC, Yu G, Lin SC, Pan T, Satcher RL, Titus MA, Yu-Lee LY, Weng WH, Gallick GE, Lin SH. Cabozantinib-induced osteoblast secretome promotes survival and migration of metastatic prostate cancer cells in bone. Oncotarget 8(43):74987-75006, 2017. e-Pub 2017. PMID: 29088840.
17. Bilen MA, Pan T, Lee YC, Lin SC, Yu G, Pan J, Hawke D, Pan BF, Vykoukal J, Gray K, Satcher RL, Gallick GE, Yu-Lee LY, Lin SH. Proteomics Profiling of Exosomes from Primary Mouse Osteoblasts under Proliferation versus Mineralization Conditions and Characterization of Their Uptake into Prostate Cancer Cells. J Proteome Res 16(8):2709-2728, 2017. e-Pub 2017. PMID: 28675788.
18. Zeng H, Ortiz A, Shen PF, Cheng CJ, Lee YC, Yu G, Lin SC, Creighton CJ, Yu-Lee LY, Lin SH. Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget 8(6):10145-10160, 2017. e-Pub 2017. PMID: 28052036.
19. Lee YC, Lin SC, Yu G, Cheng CJ, Liu B, Liu HC, Hawke DH, Parikh NU, Varkaris A, Corn P, Logothetis C, Satcher RL, Yu-Lee LY, Gallick GE, Lin SH. Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer. Cancer Res 75(22):4949-59, 2015. e-Pub 2015. PMID: 26530902.
20. Ortiz A, Lee YC, Yu G, Liu HC, Lin SC, Bilen MA, Cho H, Yu-Lee LY, Lin SH. Angiomotin is a novel component of cadherin-11/beta-catenin/p120 complex and is critical for cadherin-11-mediated cell migration. FASEB J 29(3):1080-91, 2015. e-Pub 2015. PMID: 25466890.
21. Yu G, Jiang P, Xiang Y, Zhang Y, Zhu Z, Zhang C, Lee S, Lee W, Zhang Y. Increased expression of protease-activated receptor 4 and Trefoil factor 2 in human colorectal cancer. PLoS One 10(4):e0122678, 2015. e-Pub 2015. PMID: 25876034.
22. Li SM, Jiang P, Xiang Y, Wang WW, Zhu YC, Feng WY, Li SD, Yu GY. Protease-activated receptor (PAR)1, PAR2 and PAR4 expressions in esophageal squamous cell carcinoma. Dongwuxue Yanjiu 35(5):420-5, 2014. e-Pub 2014. PMID: 25297082.
23. Jiang P, Yu G, Zhang Y, Xiang Y, Zhu Z, Feng W, Lee W, Zhang Y. Promoter hypermethylation and downregulation of trefoil factor 2 in human gastric cancer. Oncol Lett 7(5):1525-1531, 2014. e-Pub 2014. PMID: 24765170.
24. Satcher RL, Pan T, Cheng CJ, Lee YC, Lin SC, Yu G, Li X, Hoang AG, Tamboli P, Jonasch E, Gallick GE, Lin SH. Cadherin-11 in renal cell carcinoma bone metastasis. PLoS One 9(2):e89880, 2014. e-Pub 2014. PMID: 24587095.
25. Lee YC, Bilen MA, Yu G, Lin SC, Huang CF, Ortiz A, Cho H, Song JH, Satcher RL, Kuang J, Gallick GE, Yu-Lee LY, Huang W, Lin SH. Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis. Mol Cancer Res 11(11):1401-11, 2013. e-Pub 2013. PMID: 23913163.
26. Jiang P, Xiang Y, Wang YJ, Li SM, Wang Y, Hua HR, Yu GY, Zhang Y, Lee WH, Zhang Y. Differential expression and subcellular localization of Prohibitin 1 are related to tumorigenesis and progression of non-small cell lung cancer. Int J Clin Exp Pathol 6(10):2092-101, 2013. e-Pub 2013. PMID: 24133587.
27. Jiang P, Yu GY, Zhang Y, Xiang Y, Hua HR, Bian L, Wang CY, Lee WH, Zhang Y. Down-regulation of protease-activated receptor 4 in lung adenocarcinoma is associated with a more aggressive phenotype. Asian Pac J Cancer Prev 14(6):3793-8, 2013. e-Pub 2013. PMID: 23886184.
28. Lei W, Huang Y, Zhang Y, Yu G, Wan S, Lee W, Zhang Y. The frog trefoil factor Bm-TFF2 activates human platelets via Gq and G12/13 signaling pathway. Toxicon 59(1):104-9, 2012. e-Pub 2012. PMID: 22100826.
29. Zhang Y, Yu G, Wang Y, Xiang Y, Gao Q, Jiang P, Zhang J, Lee W, Zhang Y. Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2. Cell Mol Life Sci 68(22):3771-80, 2011. e-Pub 2011. PMID: 21461878.
30. Zhang Y, Yu G, Jiang P, Xiang Y, Li W, Lee W, Zhang Y. Decreased expression of protease-activated receptor 4 in human gastric cancer. Int J Biochem Cell Biol 43(9):1277-83, 2011. e-Pub 2011. PMID: 21635966.
31. Zhang Y, Yu G, Wang D, Hu Y, Lei W. ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. Toxicon 57(6):932-7, 2011. e-Pub 2011. PMID: 21419152.
32. Lei W, Zhang Y, Yu G, Jiang P, He Y, Lee W, Zhang Y. Cloning and sequence analysis of an Ophiophagus hannah cDNA encoding a precursor of two natriuretic peptide domains. Toxicon 57(5):811-6, 2011. e-Pub 2011. PMID: 21334357.
33. Chen Z, Wu J, Zhang Y, Yang X, Yu G, Zhu S, Lee W, Lu Q, Zhang Y. A novel platelet glycoprotein Ib-binding protein with human platelet aggregation-inhibiting activity from Trimeresurus jerdonii venom. Toxicon 57(5):672-9, 2011. e-Pub 2011. PMID: 21256857.
34. Chen ZM, Wu JB, Zhang Y, Yu GY, Lee WH, Lu QM, Zhang Y. Jerdonuxin, a novel snaclec (snake C-type lectin) with platelet aggregation activity from Trimeresurus jerdonii venom. Toxicon 57(1):109-16, 2011. e-Pub 2011. PMID: 21040740.
35. Yu GY, Zhang HY, Zhang Y, Jiang P, Lee WH, Zhang Y. [Expression and identification of Bm-TFF2 in Pichia pastoris]. Dongwuxue Yanjiu 31(6):565-9, 2010. e-Pub 2010. PMID: 21174343.
36. Yu G, Zhang Y, Xiang Y, Jiang P, Chen Z, Lee W, Zhang Y. Cell migration-promoting and apoptosis-inhibiting activities of Bm-TFF2 require distinct structure basis. Biochem Biophys Res Commun 400(4):724-8, 2010. e-Pub 2010. PMID: 20816935.
37. Zhang Y, Yu G, Wang Y, Zhang J, Wei S, Lee W, Zhang Y. A novel annexin A2 protein with platelet aggregation-inhibiting activity from amphibian Bombina maxima skin. Toxicon 56(3):458-65, 2010. e-Pub 2010. PMID: 20466017.
38. Zhang Y, Zhao H, Yu GY, Liu XD, Shen JH, Lee WH, Zhang Y. Structure-function relationship of king cobra cathelicidin. Peptides 31(8):1488-93, 2010. e-Pub 2010. PMID: 20576537.
39. Zhang Y, Yu G, Xiang Y, Wu J, Jiang P, Lee W, Zhang Y. Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing. Biochem Biophys Res Commun 398(3):559-64, 2010. e-Pub 2010. PMID: 20599756.

Abstracts

1. Yu G, Li J, Tian X, Lin H, Wang X. [Changes of protein tyrosine phosphorylation in erythrocyte band 3 glucose-6-phosphate dehydrogenase deficiency]. Zhonghua Xue Ye Xue Za Zhi 23(11):565-7, 2002. e-Pub 2002. PMID: 12482337.