Meet Jeffrey How, M.D.
Jeffrey How, MD MPH MS
Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery
About Jeffrey How
Dr. How is an Assistant Professor in the Department of Gynecologic Oncology at the University of Texas MD Anderson Cancer Center. He obtained his Medical Degree and completed his residency in Obstetrics and Gynecology at McGill University in Montreal, Canada. He received a Master of Public Health with a concentration in Epidemiology from the Harvard T.H. Chan School of Public Health in Boston. Furthermore, he completed a Master of Science in Biomedical Sciences with a concentration in Immunology at the UT Health MD Anderson Cancer Center Graduate School of Biomedical Sciences. Additionally, he completed a fellowship in Gynecologic Oncology at the University of Texas MD Anderson Cancer Center.
His research interests include immunotherapy research, innovative clinical trial designs, and translational research for the predictive markers of response and resistance for immunotherapy/targeted therapy.
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2021 | The University of Texas M.D. Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, Texas, US, Biochemical Sciences, Master of Science |
| 2017 | Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, US, Epidemiology, Master of Public Health |
| 2014 | McGill University School of Medicine, Montreal, CA, MD |
Postgraduate Training
| 2019-2023 | Clinical Fellowship, Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas |
| 2017-2017 | Felix Rutledge Fellowship, Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas |
| 2014-2019 | Clinical Residency, Obstetrics and Gynecology, McGill University, Montreal |
Experience & Service
Institutional Committee Activities
Committee Member, Junior Faculty Committee, 2023 - Present
Representative of the Department of Gynecologic Oncology and Reproductive Medicine, Faculty Senate, 2023 - Present
Clinical Quality Improvement Fellow, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 2022 - 2023
Gynecologic Oncology Fellowship Program Representative, House Staff Senate, The University of Texas MD Anderson Cancer Center, 2020 - 2021
Fellowship Program Education Committee Member, The University of Texas MD Anderson Gynecologic Oncology Fellowship, 2019 - Present
Residency Program Committee, McGill University Obstetrics and Gynecology Residency, 2018 - 2018
MORE (OB) Quality Improvement Committee, Royal Victoria Hospital Department of Obstetrics and Gynecology, 2016 - 2018
Honors & Awards
| Yale Book Award for outstanding personal character and promise of intellectual achievement, Yale Club of Montreal | |
| Recipient of the Fonds de la recherche en santé du Québec Summer Research Bursary | |
| Award for Best Scientific Oral Presentation, Young Doctors’ summit of the 14th biennial meeting of the International Gynecologic Cancer Society | |
| Recipient of travel grant to the Shingo Fujii Young Doctors’ Summit at the 15th biennial meeting of the International Gynecologic Cancer Society, 15th biennial meeting of the International Gynecologic Cancer Society | |
| Harvard School of Public Health Grant for studies for the academic year 2015 – 2016, Harvard School of Public Health | |
| Award for Professionalism in Obstetrics and Gynecology for the academic year 2015 – 2016, St. Mary’s Hospital Department of Obstetrics and Gynecology | |
| Selected to represent McGill University for “best of the best resident research presentations”, 2016 Annual Meeting of the Association of Academic Professionals of Obstetrics and Gynecology of Canada | |
| Harvard School of Public Health Grant for studies for the academic year 2016 – 2017, Harvard School of Public Health | |
| Award for Professionalism in Obstetrics and Gynecology for the academic year 2016 – 2017, Jewish General Hospital Department of Obstetrics and Gynecology | |
| Brian Newton Memorial Prize for Excellence in Gynecologic Oncology for the academic year 2016 – 2017, McGill University Department of Obstetrics and Gynecology | |
| Award for best oral presentation for residents and fellows, 51st annual meeting of the Association of Obstetricians and Gynecologists of Quebec | |
| Erin and Jane Molson Award for Excellence in Research for the academic year 2018 – 2019, McGill University Department of Obstetrics and Gynecology | |
| Immunology Program First-author Review Incentive Award, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences | |
| Dr. Henry R. Shibata Fellowship Award, Cedars Cancer Foundation | |
| The University of Texas MD Anderson Gynecologic Oncology Fellowship Program Service Award | |
| Thomas H. and Mayme P. Scott Fellowship in Cancer Research, The University of Texas MD Anderson Cancer Center Trainee Research Day 2021 | |
| Second place in the Oral Competition for Clinical Research, The University of Texas MD Anderson Cancer Center Trainee Research Day 2021 | |
| Recipient of the 2022 Dr. Chien-Tien Hsu Fellow Scholarship in Gynecologic Oncology, Hsu Medical Education Foundation | |
| 2022 AACR-Doreen Putrah Cancer Research Foundation Scholar-in-Training Award, Annual Meeting of the American Association for Cancer Research | |
| Linda Manning Fellowship in Ovarian Cancer Research Award, The University of Texas MD Anderson Cancer Center | |
| Society of Gynecologic Oncology Bridges Research Initiative Scholar | |
| 2023 American Society of Clinical Oncology Annual Meeting Merit Award, Conquer Cancer, the ASCO Foundation |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Gouda MA, Stephen B, Tian Y, Alshawa A, Onwugaje DOC, Albittar A, Yang Y, Zarifa A, Yilmaz B, Gurses S, Sprenger A, Derbala MH, Brink A, How JA, Moyers J, Piha-Paul SA, Hong DS, Meric-Bernstam F, Patel SP, Oliva IG. A Phase Ib Study of Selinexor in Combination with Pembrolizumab in Patients with Metastatic Melanoma. J Immunother Precis Oncol 7(4):247-254, 2024. PMID: 39524469.
- Brodsky AL, Legarreta AF, Fellman BM, Glassman D, How J, Vuttaradhi V, Sood AK, Ramondetta LM, Gershenson D, Hillman RT. TERT promoter mutations and survival outcomes in adult-type granulosa cell tumors. Int J Gynecol Cancer None(None):None, 2024. PMID: 39395821.
- How JA, Dang M, Lee S, Fellman B, Westin SN, Sood AK, Fleming ND, Shafer A, Yuan Y, Liu J, Zhao L, Celestino J, Hajek R, Morgan MB, Parra ER, Laberiano Fernandez CD, Arrechedera CA, Solis Soto LM, Schmeler KM, Nick A, Lu KH, Coleman R, Wang L, Jazaeri AA. Phase II trial of pembrolizumab in combination with chemotherapy for frontline treatment of advanced epithelial ovarian cancer. Med None(None):None, 2024. PMID: 39151421.
- How, JA, Legarreta, AF, Handley, KF, Fellman, B, Foster, KI, Glassman, D, Vuttaradhi, VK, Brodsky, AL, Lawson, BC, Frumovitz, M, Westin, SN, Ramondetta, LM, Gershenson, DM, Sood, AK, Hillman, RT. Serial cytoreductive surgery and survival outcomes in recurrent adult-type ovarian granulosa cell tumors. American journal of obstetrics and gynecology 230(5):544.e1-544.e13, 2024. PMID: 38191019.
- Bernard, L, How, JA, Patel, S, Yates, MS, Jazaeri, AA. Obesity is associated with improved progression-free survival in Microsatellite-Instability-High endometrial cancer treated with pembrolizumab. Gynecologic oncology 180:139-145, 2024. PMID: 38091773.
- Foster KI, Flores Legarreta A, Kamat R, Handley KF, Glassman D, How JA, Lawson BC, Westin SN, Ramondetta LM, Frumovitz M, Gershenson DM, Sood AK, Hillman RT. Clinical outcomes of leuprolide acetate in the treatment of recurrent ovarian granulosa cell tumors. Am J Obstet Gynecol 228(6):724.e1-724.e9, 2023. e-Pub 2023. PMID: 36907533.
- How JA, Jazaeri AA, Fu S, Rodon Ahnert J, Gong J, Stephen B, Ferreira Dalla Pria H, Bhosale P, Johnson A, Yuan Y, Meric-Bernstam F, Naing A. Clinical Outcomes of Patients with Recurrent Microsatellite-Stable Endometrial Cancer in Early-Phase Immunotherapy Clinical Trials. Cancers (Basel) 14(15), 2022. e-Pub 2022. PMID: 35954359.
- How JA, Patel S, Fellman B, Lu KH, Hwu P, Ramondetta LM, Westin SN, Fleming ND, Soliman PT, Jazaeri AA. Toxicity and efficacy of the combination of pembrolizumab with recommended or reduced starting doses of lenvatinib for treatment of recurrent endometrial cancer. Gynecol Oncol 162(1):24-31, 2021. e-Pub 2021. PMID: 33958211.
- Turkdogan S, Schnitman G, Wang T, Gotlieb R, How J, Gotlieb WH. Development of a Digital Patient Education Tool for Patients With Cancer During the COVID-19 Pandemic. JMIR Cancer 7(2):e23637, 2021. e-Pub 2021. PMID: 34101611.
- How JA, Jazaeri AA, Fellman B, Daniels MS, Penn S, Solimeno C, Yuan Y, Schmeler K, Lanchbury JS, Timms K, Lu KH, Yates MS. Modification of Homologous Recombination Deficiency Score Threshold and Association with Long-Term Survival in Epithelial Ovarian Cancer. Cancers (Basel) 13(5):1-18, 2021. e-Pub 2021. PMID: 33668244.
- How JA, Jazaeri AA, Soliman PT, Fleming ND, Gong J, Piha-Paul SA, Janku F, Stephen B, Naing A. Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial. Sci Rep 11(1):3667, 2021. e-Pub 2021. PMID: 33574401.
- Kogan L, Matanes E, Wissing M, Mitric C, How J, Amajoud Z, Abitbol J, Yasmeen A, López-Ozuna V, Eisenberg N, Lau S, Salvador S, Gotlieb WH. The added value of sentinel node mapping in endometrial cancer. Gynecol Oncol 158(1):84-91, 2020. e-Pub 2020. PMID: 32349874.
- Abitbol J, Gotlieb W, Zeng Z, Ramanakumar A, Kessous R, Kogan L, Pare-Miron V, Rombaldi M, Salvador S, Kucukyazici B, Brin S, How J, Lau S. Incorporating robotic surgery into the management of ovarian cancer after neoadjuvant chemotherapy. Int J Gynecol Cancer 29(9):1341-1347, 2019. e-Pub 2019. PMID: 31601648.
- Wissing M, Mitric C, Amajoud Z, Abitbol J, Yasmeen A, López-Ozuna V, How J, Kessous R, Eisenberg N, Lau S, Salvador S, Gotlieb WH, Kogan L. Risk factors for lymph nodes involvement in obese women with endometrial carcinomas. Gynecol Oncol 155(1):27-33, 2019. e-Pub 2019. PMID: 31349997.
- Kessous R, How J, Abitbol J, Puzhakkal S, Kogan L, Yasmeen A, Salvador S, Gotlieb WH, Lau S. Triple tracer (blue dye, indocyanine green, and Tc99) compared to double tracer (indocyanine green and Tc99) for sentinel lymph node detection in endometrial cancer: a prospective study with random assignment. Int J Gynecol Cancer 29(7):1121-1125, 2019. e-Pub 2019. PMID: 31320490.
- 17Abitbol J, Lau S, Salvador S, How J, Kogan L, Kessous R, Brin S, Drummond N, Ramanakumar AV, Gotlieb R, Tatar A, Gomolin A, Gotlieb WH. A three-pronged approach to evaluating robotic surgery. Gynecol Pelvic Med:2(15):1 - 12, 2019. PMID: None.
- How J, Boldeanu I, Lau S, Salvador S, How E, Gotlieb R, Abitbol J, Halder A, Amajoud Z, Probst S, Brin S, Gotlieb W. Unexpected locations of sentinel lymph nodes in endometrial cancer. Gynecol Oncol 147(1):18-23, 2017. e-Pub 2017. PMID: 28716308.
- How J, Gauthier C, Abitbol J, Lau S, Salvador S, Gotlieb R, Pelmus M, Ferenczy A, Probst S, Brin S, Fatnassi A, Gotlieb W. Impact of sentinel lymph node mapping on recurrence patterns in endometrial cancer. Gynecol Oncol 144(3):503-509, 2017. e-Pub 2017. PMID: 28104296.
- How J, Gotlieb WH, Press JZ, Abitbol J, Pelmus M, Ferenczy A, Probst S, Gotlieb R, Brin S, Lau S. Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer. Gynecol Oncol 137(3):436-42, 2015. e-Pub 2015. PMID: 25870917.
- Zeng XZ, Lavoue V, Lau S, Press JZ, Abitbol J, Gotlieb R, How J, Wang Y, Gotlieb WH. Outcome of robotic surgery for endometrial cancer as a function of patient age. Int J Gynecol Cancer 25(4):637-44, 2015. PMID: 25723778.
- How JA, Abitbol J, Lau S, Gotlieb WH, Abenhaim HA. The impact of qualitative research on gynaecologic oncology guidelines. J Obstet Gynaecol Can 37(2):138-144, 2015. PMID: 25767946.
- Lau S, Aubin S, Rosberger Z, Gourdji I, How J, Gotlieb R, Drummond N, Eniu I, Abitbol J, Gotlieb W. Health-related quality of life following robotic surgery: a pilot study. J Obstet Gynaecol Can 36(12):1071-1078, 2014. PMID: 25668042.
- Abitbol J, Lau S, Ramanakumar AV, Press JZ, Drummond N, Rosberger Z, Aubin S, Gotlieb R, How J, Gotlieb WH. Prospective quality of life outcomes following robotic surgery in gynecologic oncology. Gynecol Oncol 134(1):144-9, 2014. e-Pub 2014. PMID: 24796633.
- Lavoue V, Zeng X, Lau S, Press JZ, Abitbol J, Gotlieb R, How J, Wang Y, Gotlieb WH. Impact of robotics on the outcome of elderly patients with endometrial cancer. Gynecol Oncol 133(3):556-62, 2014. e-Pub 2014. PMID: 24708920.
- How J, Lau S, Press J, Ferenczy A, Pelmus M, Stern J, Probst S, Brin S, Drummond N, Gotlieb W. Accuracy of sentinel lymph node detection following intra-operative cervical injection for endometrial cancer: a prospective study. Gynecol Oncol 127(2):332-7, 2012. e-Pub 2012. PMID: 22910695.
- Halliday D, Lau S, Vaknin Z, Deland C, Levental M, McNamara E, Gotlieb R, Kaufer R, How J, Cohen E, Gotlieb WH. Robotic radical hysterectomy: comparison of outcomes and cost. J Robot Surg 4(4):211-6, 2010. e-Pub 2010. PMID: 27627947.
Other Articles
- How JA, Jazaeri AA, Westin SN, Lawson BC, Klopp AH, Soliman PT, Lu KH Translating biological insights into improved management of endometrial cancer. Nat Rev Clin Oncol 21(11):781-800, 2024. PMID: 39198622.
- How, JA, Jazaeri, AA Immunotherapy in locally advanced cervical cancer. Med 5(6):487-489, 2024. PMID: 38878765.
- Boast A, How JA, Lau C, Sett A, Gilby D, Burke A, McWhinney B, Wright C, Tramontana A, Globan M, Denholm J, Graham SM, Osowicki J Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby. Clin Infect Dis 78(1):149-153, 2024. PMID: 37681559.
- Batman S, Rauh-Hain JA, Grinsfelder MO, Harrison R, Avila M, Cun H, How JA, Tandon N, Wang X, Hinchcliff E, Jazaeri AA, Schmeler KM Exceptional Response to Pembrolizumab for Treatment of Metastatic Chemorefractory Endometrial Carcinoma in a Patient with Lynch Syndrome: A Case Report. Case Rep Oncol 16(1):273-278, 2023. PMID: 37123608.
- How JA, Frumovitz M, Stewart KI, Soliman PT Lymphatic Mapping and Sentinel Node Biopsy in High-Grade Uterine Cancers. Curr Oncol Rep 24(11):1521-1529, 2022. PMID: 35781863.
- Schnitman G, Wang T, Kundu S, Turkdogan S, Gotlieb R, How J, Gotlieb W The role of digital patient education in maternal health: A systematic review. Patient Educ Couns 105(3):586-593, 2022. PMID: 34183217.
- Marchocki Z, Cusimano MC, Clarfield L, Kim SR, Fazelzad R, Espin-Garcia O, Bouchard-Fortier G, Rossi EC, Stewart KI, Soliman PT, How JA, Gotlieb WH, Holloway RW, Ianieri MM, Cabrera S, Lim YK, Ferguson SE Sentinel lymph node biopsy in high-grade endometrial cancer: a systematic review and meta-analysis of performance characteristics. Am J Obstet Gynecol 225(4):367.e1-367.e39, 2021. PMID: 34058168.
- How JA, Jazaeri A, Westin SN, Sood AK, Ramondetta LM, Xu M, Abonofal A, Karp DD, Subbiah V, Stephen B, Rodon JA, Yang F, Naing A The clinical efficacy and safety of single-agent pembrolizumab in patients with recurrent granulosa cell tumors of the ovary: a case series from a phase II basket trial. Invest New Drugs 39(3):829-835, 2021. PMID: 33415580.
- How JA, Siedel JH, Shafer A Post-operative gastroparesis following carbohydrate loading in a diabetic patient. Gynecol Oncol Rep 36:100714, 2021. PMID: 33644283.
- Gotlieb R, Abitbol J, How JA, Ben-Brith I, Abenhaim HA, Lau SK, Basik M, Rosberger Z, Geva N, Gotlieb WH, Mintz A Gender differences in how physicians access and process information. Gynecol Oncol Rep 27:50-53, 2019. PMID: 30662932.
- Nguyen DB, How J, Ziegler C, Madar J Acute Respiratory Distress Syndrome After Uterine Artery Embolization. Obstet Gynecol 132(4):956-959, 2018. PMID: 30204705.
- Bougie O, Zuckerman SL, Switzer N, How J, Sey M Influence of Resident Involvement in Obstetrics and Gynaecology Surgery on Surgical Outcomes: Systematic Review and Meta-Analysis. J Obstet Gynaecol Can 40(9):1170-1177, 2018. PMID: 30007802.
- How JA, O'Farrell P, Amajoud Z, Lau S, Salvador S, How E, Gotlieb WH Sentinel lymph node mapping in endometrial cancer: a systematic review and meta-analysis. Minerva Ginecol 70(2):194-214, 2018. PMID: 29185673.
- Drudi L, Press JZ, Lau S, Gotlieb R, How J, Eniu I, Drummond N, Brin S, Deland C, Gotlieb WH Vaginal vault dehiscence after robotic hysterectomy for gynecologic cancers: search for risk factors and literature review. Int J Gynecol Cancer 23(5):943-50, 2013. PMID: 23669442.
Book Chapters
- How JA, Abitbol J, Gotlieb WH. Minimally invasive surgery in ovarian cancer. In: Surgery for ovarian cancer. 4th. CRC Press, None, 2023.
- How JA, Patel A, Jazaeri AA. Immuno-oncology for Gynecologic Malignancies. In: Immunotherapy. 4th. Springer Nature, 193-232, 2022.
- How J, Patel A, Jazaeri A. Immuno-oncology for Gynecologic Malignancies. In: Immunotherapy. 3rd. Springer Nature, None, 2020.
- How J, Gotlieb WH. Sentinel lymph node evaluation in endometrial cancer. In: Uterine Cancer: Diagnosis & Management. None. None, 2014.
Patient Reviews
CV information above last modified December 03, 2024