Jian Wang, PhD

Peer-Reviewed Articles

1. Zaky W, Ragoonanan D, Batth I, Dao L, Wang J, Xia X, Daw NC, Gill JB, Khatua S, Li S. Automated Capture and Analysis of Circulating Tumor Cells in Pediatric, Adolescent and Young Adult Patients with Central Nervous System Tumors. Cancers (Basel) 15(15), 2023. e-Pub 2023. PMID: 37568669.
2. Hahn AW, Menk AV, Rivadeneira DB, Augustin RC, Xu M, Li J, Wu X, Mishra AK, Gide TN, Quek C, Zang Y, Spencer CN, Menzies AM, Daniel CR, Hudgens CW, Nowicki T, Haydu LE, Khan MAW, Gopalakrishnan V, Burton EM, Malke J, Simon JM, Bernatchez C, Putluri N, Woodman SE, Gopal Y N V, Guerrieri R, Fischer GM, Wang J, Wani KM, Thompson JF, Lee JE, Hwu P, Ajami N, Gershenwald JE, Long GV, Scolyer RA, Tetzlaff MT, Lazar AJ, Schadendorf D, Wargo JA, Kirkwood JM, DeBerardinis RJ, Liang H, Futreal A, Zhang J, Wilmott JS, Peng W, Davies MA, Delgoffe GM, Najjar YG, McQuade JL. Obesity is associated with altered tumor metabolism in metastatic melanoma. Clin Cancer Res. e-Pub 2022. PMID: 36166093.
3. Aggarwal P, Hutcheson KA, Yu R, Wang J, Fuller CD, Garden AS, Goepfert RP, Rigert J, Mott FE, Lu C, Lai SY, Gunn GB, Chambers MS, Li G, Wu CC, Hanna EY, Sturgis EM, Shete S. Genetic susceptibility to patient-reported xerostomia among long-term oropharyngeal cancer survivors. Sci Rep 12(1):6662, 2022. e-Pub 2022. PMID: 35459784.
4. Sheikh IN, Miller J, Shoberu B, Andersen CR, Wang J, Williams LA, Mahadeo KM, Robert R. Using the MDASI-Adolescent for early symptom identification and mitigation of symptom impact on daily living in adolescent and young adult stem cell transplant patients. Children (Basel) 9(1):19, 2021. e-Pub 2021. PMID: 35053644.
5. John JC, Wang J, McNeill LHM, Basen-Engquist K, Hoover DS, Daniel CR, Strong LL. A mixed methods study on engagement and satisfaction with a digitally-enhanced pilot intervention among African American and Hispanic women. J Immigr Minor Health 23(5):1011-1020, 2021. e-Pub 2020. PMID: 33043411.
6. Wang J, Ma J, Cai C, Daver N, Ning J. A Bayesian hierarchical monitoring design for phase II cancer clinical trials: incorporating information on response duration into monitoring rules. Stat Med 40(21):4629-4639, 2021. e-Pub 2021. PMID: 34101217.
7. Wang J, Reyes-Gibby C, Shete S. An approach to analyze longitudinal zero-inflated microbiome count data using two-stage mixed effects models. Statistics in Biosciences 13:267-290, 2021.
8. Yan J, Zhao Q, Wang J, Tian X, Wang J, Xia X, Ott M, Rao G, Heimberger AB, Li S. FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells. Cancer Lett 506:83-94, 2021. e-Pub 2021. PMID: 33676940.
9. Chung M, Benkli B, Roldan C, Qing Y, Wang J, Huh B. Subanesthetic ketamine in the ambulatory setting for refractory cancer pain: a 6-year retrospective at a cancer center. Pain Manag 11(3):267-276, 2021. e-Pub 2021. PMID: 33533283.
10. Cuglievan B, Berkman A, Dibaj S, Wang J, Andersen CR, Livingston JA, Gill J, Bleyer A, Roth M. Impact of lagtime, health insurance type and income status at diagnosis on the long-term survival of adolescent and young adult cancer patients. J Adolesc Young Adult Oncol 10(2):164-174, 2021. e-Pub 2020. PMID: 32678703.
11. Hu J, Zhao Q, Kong LY, Wang J, Yan J, Xia X, Jia Z, Heimberger AB, Li S. Regulation of tumor immune suppression and cancer-cell survival by CXCL1/2 elevation in glioblastoma multiforme. Sci Adv 7(5), 2021. e-Pub 2021. PMID: 33571109.
12. Ragoonanan D, Khazal SJ, Wang J, Payne A, Kohorst M, Harden A, Tewari P, Petropoulos D, Shoberu B, Kebriaei P, Mahadeo KM, Tambaro FP. Improved detection of sinusoidal obstructive syndrome using pediatric-AYA diagnostic criteria and severity grading. Bone Marrow Transplant 56(1):175-184, 2021. e-Pub 2020. PMID: 32665674.
13. Wang J, Ning J, Shete S. Mediation model with a categorical exposure and a censored mediator with application to a genetic study. PLoS One 16(10):e0257628, 2021. e-Pub 2021. PMID: 34637449.
14. Dao L, Ragoonanan D, Batth I, Satelli A, Foglesong J, Wang J, Zaky W, Gill JB, Liu D, Albert A, Gordon N, Huh W, Harrison D, Herzog C, Kleinerman E, Gorlick R, Daw N, Li S. Prognostic Value of Cell-Surface Vimentin-Positive CTCs in Pediatric Sarcomas. Front Oncol 11:760267, 2021. e-Pub 2021. PMID: 34956881.
15. Batth IS, Dao L, Satelli A, Mitra A, Yi S, Noh H, Li H, Brownlee Z, Zhou S, Bond J, Wang J, Wang J, Gill J, Sholler GS, Li S. Cell Surface Vimentin Positive Circulating tumor cell-based relapse prediction in a long-term longitudinal study of post-remission neuroblastoma patients. Int J Cancer 147(12):3550-3559, 2020. e-Pub 2020. PMID: 32506485.
16. Reyes-Gibby CC*, Wang J*, Zhang L, Peterson CB, Do KA, Jenq RR, Shelburne S, Shah DP, Chambers MS, Hanna EY, Yeung SJ, Shete S. Oral microbiome and onset of oral mucositis in patients with squamous cell carcinoma of the head and neck (* equally contributed). Cancer 126(23):5124-5136, 2020. e-Pub 2020. PMID: 32888342.
17. Kohorst MA, Khazal SJ, Tewari P, Petropoulos D, Mescher B, Wang J, Mahadeo KM, Kelley JM. Transfusion reactions in pediatric and adolescent young adult haematology oncology and immune effector cell patients. EClinicalMedicine 26:100514, 2020. e-Pub 2020. PMID: 32964199.
18. Berkman AM, Livingston JA, Merriman K, Hildebrandt M, Wang J, Dibaj S, McQuade J, You N, Ying A, Barcenas C, Bodurka D, DePombo A, Lee HJ, de Groot J, Roth M. Long-term survival among 5-year survivors of adolescent and young adult cancer. Cancer 126(16):3708-3718, 2020. e-Pub 2020. PMID: 32484922.
19. Dong J, White S, Nielsen K, Banchs J, Wang J, Botz GH, Nates JL. Tricuspid Annular Plane Systolic Excursion is a Predictor of Mortality for Septic Shock. Intern Med J. e-Pub 2020. PMID: 32618101.
20. Shete S, Liu H*, Wang J*, Yu R*, Sturgis EM, Li G, Dahlstrom KR, Liu Z, Amos CI, Wei Q. A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck. (* equally contributed). Cancer Res 80(12):2451-2460, 2020. e-Pub 2020. PMID: 32276964.
21. Peng W, Williams LJ, Xu C, Melendez B, McKenzie JA, Chen Y, Jackson HL, Voo KS, Mbofung RM, Leahey SE, Wang J, Lizee G, Tawbi HA, Davies MA, Hoos A, Smothers J, Srinivasan R, Paul EM, Yanamandra N, Hwu P. Anti-OX40 antibody directly enhances the function of tumor-reactive CD8+ T cells and synergizes with PI3Kβ inhibition in PTEN loss melanoma. Clin Cancer Res 25(21):6406-6416, 2019. e-Pub 2019. PMID: 31371342.
22. Yennu-Nanda VP, Gammon S, Prasad R, Knighton B, Pisaneschi F, Roszik J, Feng N, Johnson S, Pramanik S, Sudderth J, Sui D, Hudgens C, Fischer GM, Deng W, Reuben A, Peng W, Wang J, McQuade JL, Tetzlaff MT, Di Francesco ME, Marszalek J, Piwnica-Worms D, DeBerardinis RJ, Davies MA. A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma. Clin Cancer Res 25(21):6429-6442, 2019. e-Pub 2019. PMID: 31439581.
23. Wang J, Ning J, Shete S. Mediation analysis in a case-control study when the mediator is a censored variable. Stat Med 38(7):1213-1229, 2019. e-Pub 2018. PMID: 30421436.
24. Heredia NI, Wilkinson AV, Forman MR, Christie IC, Wang J, Daniel CR, Zhao H, Bondy ML, Strong LL. Longitudinal associations of family functioning with body mass index in Mexican-origin adolescents living in the U.S. Prev Med 118:309-316, 2019. e-Pub 2018. PMID: 30419254.
25. Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S. FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun 10(1):448, 2019. e-Pub 2019. PMID: 30683885.
26. Wang J, Shete S. Estimation of indirect effect when the mediator is a censored variable. Stat Methods Med Res 27(10):962280217690414, 2018. PMID: 28132585.
27. Reyes-Gibby CC, Wang J, Yeung SJ, Chaftari P, Yu RK, Hanna EY, Shete S. Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer. Sci Rep 8(1):8789, 2018. e-Pub 2018. PMID: 29884837.
28. Mechanic LE, Lindström S, Daily KM, Sieberts SF, Amos CI, Chen HS, Cox NJ, Dathe M, Feuer EJ, Guertin MJ, Hoffman J, Liu Y, Moore JH, Myers CL, Ritchie MD, Schildkraut J, Schumacher F, Witte JS, Wang W, Williams SM, U4C Challenge Participants, U4C Challenge Data Contributors, Gillanders DM. Up For A Challenge (U4C) - Stimulating Innovation in Breast Cancer Genetic Epidemiology. PLOS Genetics 13(9):e1006945, 2017.
29. Reyes-Gibby CC, Melkonian SC, Wang J, Yu RK, Shelburne SA, Lu C, Gunn GB, Chambers MS, Hanna EY, Yeung SJ, Shete S. Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: an informative gene network analysis. PLoS One 12(7):e0180396, 2017. e-Pub 2017. PMID: 28678827.
30. Wang J, Talluri R, Shete S. Selection of X-chromosome inactivation model. Cancer Inform 16:1176935117747272, 2017. e-Pub 2017. PMID: 29308008.
31. Reyes-Gibby CC, Wang J, Silvas MR, Yu RK, Hanna EY, Shete S. Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. Scientific Reports 6:34206, 2016. e-Pub 2016. PMID: 27670397.
32. Zhu X, Wang J, Peng B, Shete S. Empirical estimation of sequencing error rates using smoothing splines. BMC Bioinformatics 17:177, 2016. e-Pub 2016. PMID: 27102907.
33. Reyes-Gibby CC*, Wang J*, Silvas M, Yu R, Yeung SC, Shete S. MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients. (* equally contributed). BMC Genet 17(1):40, 2016. e-Pub 2016. PMID: 26872611.
34. Reyes-Gibby CC, Yuan C*, Wang J*, Yeung SC, Shete S. Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. (* equally contributed). BMC Syst Biol 9:25, 2015. e-Pub 2015. PMID: 26044620.
35. Reyes-Gibby CC*, Wang J*, Yeung SC, Shete S. Informative gene network for chemotherapy-induced peripheral neuropathy. (* equally contributed). BioData Min 8:24, 2015. e-Pub 2015. PMID: 26269716.
36. Wang J, Yu R, Shete S. X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation. Genet Epidemiol 38(6):483-93, 2014. e-Pub 2014. PMID: 25043884.
37. Archer NP, Wilkinson AV, Ranjit N, Wang J, Zhao H, Swann AC, Shete S. Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. Brain Behav 4(4):521-30, 2014. e-Pub 2014. PMID: 25161819.
38. Wang J, Yu R, Shete S. Comparison of multilevel model and the family-based association test (FBAT) for identifying SNPs associated with systolic and diastolic blood pressure using GAW18 simulated data. BMC Proceedings 8(Suppl):S30, 2014. e-Pub 2014.
39. Talluri R, Wang J, Shete S. Calculation of exact p-values when SNPs are tested using multiple genetic models. BMC Genet 15(1):75, 2014.
40. Reyes-Gibby CC, Wang J, Spitz M, Wu X, Yennurajalingam S, Shete S. Genetic variations in Interleukin-8 and Interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients. J Pain Symptom Manage 46(2):161-172, 2013. e-Pub 2012. PMID: 23149083.
41. Wilkinson AV, Gabriel KP, Wang J, Bondy ML, Dong Q, Wu X, Shete S, Spitz MR. Sensation seeking genes and physical activity in youth. Genes Brain Behav 12(2):181-8, 2013. e-Pub 2012. PMID: 23190435.
42. Wang J, Shete S. Analysis of secondary phenotype involving the interactive effect of the secondary phenotype and genetic variants on the primary disease. Ann Hum Genet 76(6):484-99, 2012. e-Pub 2012. PMID: 22881407.
43. Wilkinson AV, Bondy ML, Wu X, Wang J, Dong Q, D'Amelio AM, Prokhorov AV, Pu X, Yu RK, Etzel CJ, Shete S, Spitz MR. Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants. Cancer Epidemiol Biomarkers Prev 21(1):228-38, 2012. e-Pub 2011. PMID: 22028400.
44. Wang J, Spitz MR, Amos CI, Wu X, Wetter DW, Cinciripini PM, Shete S. Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk. PLoS One 7(10):e47705, 2012. e-Pub 2012. PMID: 23077662.
45. Wang J, Shete S. Power and type I error results for a bias-correction approach recently shown to provide accurate odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. Genet Epidemiol 35(7):739-43, 2011. e-Pub 2011. PMID: 21769937.
46. Wang J, Shete S. Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. Genet Epidemiol 35(3):190-200, 2011. e-Pub 2011. PMID: 21308766.
47. Wang J, Shete S. A powerful hybrid approach to select top SNPs for genome-wide association study. BMC Genet 12(1):3, 2011. e-Pub 2011. PMID: 21211033.
48. Wang J, Shete S. Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study. PLoS One 6(11):e27642, 2011. e-Pub 2011. PMID: 22110703.
49. Huang Z*, Wang J*, Wu CC, Houlston RS, Bondy ML, Shete S. False-Negative-Rate based approach for selecting top single-nucleotide polymorphisms in the first stage of a two-stage genome-wide association study. (* equally contributed). Stat Interface 4(3):359-371, 2011. PMID: 23060946.
50. Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk. Cancer 116(14):3458-3462, 2010. PMID: 20564069.
51. Wang J, Shete S. Using both cases and controls for testing hardy-weinberg proportions in a genetic association study. Hum Hered 69(3):212-218, 2010. e-Pub 2010. PMID: 20203526.
52. Wang J, Shete S. Is the tail strength measure more powerful for genetic association test? And tail strength to combine two p-values: their correlation cannot be ignored: Authors reply. Am J Hum Genet 84(2):298-300, 2009.
53. Wang J, Shete S. A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases. Am J Hum Genet 83(1):53-63, 2008. e-Pub 2008. PMID: 18589394.

Manuals, Teaching Aids, Other Teaching Publications

1. Wang J. Recovering Bayesian networks with applications to gene regulatory networks. University of Colorado at Boulder: Boulder, CO, 2007.
2. Shaw J, Csibrik K, Wang J, Tang Y, Ramos E. Impacts of Slow the Flow Colorado on outdoor water use. Center for ReSource Conservation: Boulder, CO, 2007.
3. Baker A, Jung M, Lee C, Maslova I, Morton M, Wang J. Analysis of biological interaction networks for drug discovery. Proceedings of 12th Industrial Mathematical & Statistical Modeling Workshop: Raleigh, NC, 2006.
4. Liu EL, Lu LN, Luo G, Wang J. The application of decision-making to bid under risks. International Conference on Modern Industrial Engineering and Engineering Management in New Century: Tianjin, 2001.
5. Liu EL, Wang J, Luo G. Project bidding decision based on fuzzy logic. International Conference on Modern Industrial Engineering and Engineering Management in New Century: Tianjin, 2001.

Abstracts

1. Zhang Y, Wang J, Shen J, Galloway-Pena J, Shelburne S, Wang L, Hu J. Inverse Probability Weighting-based Mediation Analysis for Microbiome Data. 2022 American Causal Inference Conference, 2022.
2. Wang J, Shete S. A novel approach to analyze the mediation model when the mediator is a censored variable. The 67th Annual Meeting of the American Society of Human Genetics, 2017.
3. Heredia N, Strong LL, Forman MR, Christie IC, Wang J, Daniel CR, Zhao H, Bondy ML, Spitz MR, Wilkinson AV. Family social and cultural impacts on Mexican-American adolescents’ body mass index. Kay Bartholomew Eldredge Student Poster Competition, 2017.
4. Wang, J. A unified X-chromosome genetic association test accounting for different XCI processes. 2016 ICSA Applied Statistics Symposium, 2016.
5. Wang J, Shete S. Estimation of indirect effect when the mediator is a censored variable. 2016 Conference of Texas Statisticians, 2016.
6. Zhu X, Wang J, Peng B, Shete S. Empirical estimation of sequencing error rates using smoothing splines. 2015 Integrative Biostatistics Research for Imaging, Genomics, & High-throughput Technologies in Precision Medicine, 2015.
7. Wang J, Zhu X, Peng B, Shete S. Empirical estimation of sequencing error rates using smoothing splines. 24th Annual Meeting of International Genetic Epidemiology Society, 2015.
8. Wang J, Yu R, Shete S. A unified analysis approach for X-chromosome that accounts for random, skewed and escaping of X-chromosome inactivation. The 64th Annual Meeting of the American Society of Human Genetics, 2014.
9. Yuan C, Wang J, Shete S, Reyes-Gibby C. Bioinformatics and opioid addiction: gene network analysis. CPRIT Summer Program, MD Anderson Cancer Center, 2014.
10. Strong L, Wang J, Christie I, Regan S, Franzini L, Wetter D, Reitzel L, McNeill L. Pathways linking neighborhood socioeconomic context to self-rated health in African Americans in Houston, TX. 141st Annual Meeting and Exposition of American Public Health Association, 2013.
11. Wang J, Yu R, Shete S. X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escaping of X-inactivation. 22nd Annual Meeting of International Genetic Epidemiology Society, 2013.
12. Christie IC, Strong LL, Regan SD, Wang J, Reitzel LR, Wetter DW, McNeill LH. Multiple Factors of Neighborhood Deprivation Differentially Predict Physical Health in a Large African American Sample. 71st Annual Scientific Meeting of American Psychosomatic Society, 2013.
13. Wang J, Spitz MR, Amos CI, Wu X, Wetter DW, Cinciripini PM, Shete S. Multiple mediation analysis in case-control studies: application to detecting joint mediating effects of smoking and chronic obstructive pulmonary disease on the association between CHRNA5-A3 genetic locus and lung cancer risk. The 62nd Annual Meeting of the American Society of Human Genetics, 2012.
14. Wang J, Spitz MR, Amos CI, Wu X, Wetter DW, Cinciripini PM, Shete S. Method to analyze multiple mediators in case-control studies with application to detecting mediating effects of smoking and chronic obstructive pulmonary disease on the association between CHRNA5-A3 genetic locus and lung cancer risk. 21st Annual Meeting of International Genetic Epidemiology Society, 2012.
15. Wang J, Yu RK, Shete S. Comparison of multilevel model and the family-based association test (FBAT) for identifying SNPs associated with systolic and diastolic blood pressure using GAW18 simulated data. Genetic Analysis Workshop 18, 2012.
16. Yu RK, Wang J, Shete S. Family-based association test of hypertension among Mexican American. Genetic Analysis Workshop 18, 2012.
17. Wang J, Shete S. Selection of top SNPs for genome-wide association study using p values and magnitude of odds ratios. The 61st Annual Meeting of the American Society of Human Genetics, 2011.
18. Wang J, Shete S. Selection of top SNPs for genome-wide association study using p values and magnitude of odds ratios. 20th Annual Meeting of International Genetic Epidemiology Society, 2011.
19. Wang J, Shete S. Estimation of odds ratio of genetic variants for secondary phenotype associated with primary disease. 2011 IISA Conference on Probability, Statistics, and Data Analysis, 2011.
20. Wang J, Shete S. Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. 19th Annual Meeting of International Genetic Epidemiology Society, 2010.
21. Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating effects of smoking and chronic obstructive airway disease on the relationship between the CHRNA5-A3 genetic locus and lung cancer risk. Trainee Research Day Poster Finalist, MD Anderson Cancer Center, 2010.
22. Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating effects of smoking and chronic obstructive airway disease on the relationship between the CHRNA5-A3 genetic locus and lung cancer risk. 59th Annual Meeting of the American Society of Human Genetics, 2009.
23. Wang J, Shete S. A test for genetic association that incorporates information from population genetics. 58th Annual Meeting of the American Society of Human Genetics, 2008.

Book Chapters

1. Wang J, Shete S. Testing departure from Hardy-Weinberg proportions. In: Statistical Human Genetics. Methods in Molecular Biology. 2nd. Humana Press: New York, NY, 83-115, 2017.
2. Zhu X, Wang J, Reyes-Gibby C, Shete S. Processing and Analyzing Human Microbiome Data. In: Statistical Human Genetics. Methods in Molecular Biology. 2nd. Humana Press: New York, NY, 649-677, 2017.
3. Wang J, Shete S. Testing departure from Hardy-Weinberg proportions. In: Methods Mol Biol. Humana Press: USA, 77-102, 2012.