Jihye Yun, Ph.D.
Department of Genetics, Division of Division of Discovery Science
About Jihye Yun
https://www.mdanderson.org/research/departments-labs-institutes/labs/yun-laboratory.html
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Genetics, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2010 | Johns Hopkins University, School of Medicine, Baltimore, MD, USA, PHD, Cellular and Molecular Medicine Graduate Program |
Postgraduate Training
| 2012-2016 | Postdoctoral Associate, Weill Cornell Medical College, Meyer Cancer Center, New York, NY |
| 2011-2012 | Postdoctoral Associate, Harvard Medical School, Boston, MA |
Experience & Service
Academic Appointments
Assistant Professor, Department of Molecular and Human Genetics, Division of Basic Science Research, Baylor College of Medicine, Houston, TX, 2018 - 2022
Honors & Awards
| 2023 | Andrew Sabin Family Fellowship Award, Andrew Sabin Family Foundation |
| 2022 | Rising UT STARs Award, Universtiy of Texas |
| 2021 | Phi Beta Psi Award for Cancer Research, Phi Beta Psi Charity Trust |
| 2020 | Career Enhancement Program Research Award, UT MD Anderson Cancer Center |
| 2020 | Pew-Stewart Scholar Award for Cancer Research, Pew Foundation |
| 2019 | V Scholar Award for Cancer Research, V foundation |
| 2019 | Rosalind Franklin Young Investigator Award (Honorary Mention, 3rd Place), Genetics Society of America |
| 2017 | 1st Place winner in 2017 Young Investigators Award in Medicine, Weill Cornell Medical College |
| 2017 | Recruitment of First-Time, Tenure-Track Faculty Members Award, Cancer Prevention and Research Institute of Texas (CPRIT) |
| 2014 | 1st Place winner in Successful and Productive Academic Research Careers (SPARC) Conference, (SPARC) Conference |
| 2013 | Scholar-in-Training Award, AACR (American Association for Cancer Research) |
| 2010 | Young Investigator Award (Mette Strand Research Award), Johns Hopkins University School of Medicine |
| 2010 | 1st Place winner in Basic Research, Sidney Kimmel Comprehensive Cancer Center (SKCCC) Fellow Research Day |
| 2009 | Scholars-In-Training-Award, AACR (American Association for Cancer Research) |
| 2009 | Outstanding Research Award, BLSA (Baltimore Life Scientist Association) annual meeting |
Selected Publications
Peer-Reviewed Articles
- Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SK, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC, Yun J. High-fructose corn syrup enhances intestinal tumor growth in mice. Science 363(6433):1345-1349, 2019. PMID: 30898933.
- Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Proc Natl Acad Sci U S A 113(27):7596-601, 2016. e-Pub 2016. PMID: 27313209.
- Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science 350(6266):1391-6, 2015. e-Pub 2015. PMID: 26541605.
- Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz ÖH, Bronson RT, Martin ES, Tsichlis PN, Hung KE. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Lett 347(2):204-11, 2014. e-Pub 2014. PMID: 24576621.
- Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska IA, Yu J, Kwiatkowski DJ, Locasale JW, Asara JM, Choi AM, Finkel T, Henske EP. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol Cancer Res 12(1):48-57, 2014. e-Pub 2013. PMID: 24296756.
- Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 325(5947):1555-9, 2009. e-Pub 2009. PMID: 19661383.
- Lee YJ, Hong KH, Yun J, Oh SP. Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis 44(10):487-94, 2006. PMID: 16991118.
- Seki T, Hong KH, Yun J, Kim SJ, Oh SP. Isolation of a regulatory region of activin receptor-like kinase 1 gene sufficient for arterial endothelium-specific expression. Circ Res 94(8):e72-7, 2004. e-Pub 2004. PMID: 15059937.
- Seki T, Yun J, Oh SP. Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res 93(7):682-9, 2003. e-Pub 2003. PMID: 12970115.
- Yun J, Park CW, Lee YJ, Chung JH. Allele-specific methylation at the promoter-associated CpG island of mouse Copg2. Mamm Genome 14(6):376-82, 2003. PMID: 12879359.
- Kim J, Hahn Y, Sohn EH, Lee YJ, Yun JH, Kim JM, Chung JH. Phenotypic variation of a Thr704Met mutation in skeletal sodium channel gene in a family with paralysis periodica paramyotonica. J Neurol Neurosurg Psychiatry 70(5):618-23, 2001. PMID: 11309455.
- Hahn Y, Lee YJ, Yun JH, Yang SK, Park CW, Mita K, Huh TL, Rhee M, Chung JH. Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. FEBS Lett 482(1-2):31-6, 2000. PMID: 11018518.
- Lee YJ, Park CW, Hahn Y, Park J, Lee J, Yun JH, Hyun B, Chung JH. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett 472(2-3):230-4, 2000. PMID: 10788617.
Invited Articles
- Ngo B, Van Riper JM, Cantley LC, Yun J. Targeting cancer vulnerabilities with high-dose vitamin C. Nat Rev Cancer 19(5):271-282, 2019. PMID: 30967651.
- Yun J, Johnson JL, Hanigan CL, Locasale JW. Interactions between epigenetics and metabolism in cancers. Front Oncol 2:163, 2012. e-Pub 2012. PMID: 23162793.
- Yun J. Allosteric AKT inhibitors as a targeted cancer therapy. Cancer Biol Ther 9(7):504-6, 2010. e-Pub 2010. PMID: 20484970.
Book Chapters
- Yun J, George P, Brown E, Klempner S and Cantley LC. In: MOLECULAR PATHOGENESIS OF COLORECTAL CANCER, 2013.
Grant & Contract Support
| Title: | NCI Transition Career Development Award |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Recruitment of First-Time, Tenure-Track Faculty Members Awards |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | V Scholar for Cancer Research |
| Funding Source: | V Foundation |
| Role: | Principal Investigator |
| Title: | MD Anderson Cancer Center SPORE in Gastrointestinal Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Pew-Stewart Scholar for Cancer Research |
| Funding Source: | Pew Charitable Trusts |
| Role: | Principal Investigator |
| Title: | Dan L Duncan Comprehensive Cancer Center (DLDCC) Pilot Project Award |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Decoding the Sugar-Microbiome-Cancer Connection |
| Funding Source: | Phi Beta Psi Charity Trust |
| Role: | Principal Investigator |
| Title: | Equipment Grant for Rising Stars at TMC |
| Funding Source: | UT STARS |
| Role: | Principal Investigator |
| Title: | Effects of Sugary Drinks on Colorectal Cancer Metastasis |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Impact of Sugary Drinks on Colorectal Cancer Development |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Sabin Family Fellowship Award |
| Funding Source: | Andrew Sabin Family Foundation |
| Role: | Principal Investigator |
| Title: | Role of dietary sugar in humanized Apc mutant mice |
| Funding Source: | Colorectal Cancer Moonshot |
| Role: | Co-Principal Investigator |
Patient Reviews
CV information above last modified December 05, 2023