Joseph H. McCarty, Ph.D.
Department of Neurosurgery, Division of Surgery
Present Title & Affiliation
Primary Appointment
Professor, Neurosurgery - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Member (Joint appointment), Neurosurgery, Baylor College of Medicine, Houston, TX
Member (Joint appointment), Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Neurosurgery - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Neurosurgery - Research, Baylor College of Medicine, Houston
Director of the Brain Microenvironment Research Program, The University of Texas MD Anderson Cancer Center, Houston
Research Interests
The McCarty Lab uses mouse genetics to study how integrins and their extracellular matrix (ECM) protein ligands regulate the development and physiology of the central nervous system (CNS). Additional interests include understanding how abnormal regulation of integrin and ECM protein expression and functions lead to CNS pathologies, including birth defects, stroke and cancer. In particular, we study cell adhesion and signaling pathways that mediate bi-directional communication between glial cells and vascular cells within the CNS. The billions of neurons and glial cells in the CNS are intertwined with a complex web of blood vessels. These various neural and vascular cell types dynamically interact with each other to form integrated complexes, or neurovascular units, that regulate the structural and functional integrity of the CNS and have causative links to many CNS pathologies. We have identified integrins and their ECM protein ligands as essential regulators of neurovascular development and physiology in the CNS. One integrin, alphaVbeta8, which is expressed in perivascular neuroepithelial cells and astrocytes, is of particular interest. This integrin is a receptor for latent TGFbeta's (LAP-TGFb's) which are expressed by cells as inactive ECM-associated complexes. Genetic ablation of alphaVbeta8 integrin or the TGFb's lead to strikingly similar developmental neurovascular defects, including abnormal CNS angiogenesis, hemorrhage and premature death. Hence, alphaVbeta8 integrin and latent TGFb's are components of an adhesion and signaling axis that link perivascualr glial cells, vascular basement membranes and cerebral endothelial cells. Current efforts in the lab involve characterizing mechanisms that link the components of this axis as well as using this axis as a foundation to identify other genes and signaling pathways important for neurovascular development and disease.
McCarty Lab Website - Please click this link to view it: http://www.mdanderson.org/education-and-research/departments-programs-and-labs/labs/mccarty-lab/index.html
Education & Training
Degree-Granting Education
| 1998 | University of California, Santa Barbara, California, US, Biochemistry and Molecular Biology, Ph.D |
| 1989 | University of Maryland, Baltimore, Maryland, US, Biochemistry, BS |
Postgraduate Training
| 1998-2005 | Post-Doc, Molecular Genetics, Massachusetts Institute of Technology, Cambridge, Massachusetts |
Experience & Service
Faculty Academic Appointments
Associate Professor, Neurosurgery - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2018
Associate Professor, Neurosurgery - Research, Baylor College of Medicine, Houston, 2013 - 2018
Associate Professor, Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2013
Member, Center for Stem Cell and Developmental Biology, Houston, TX, 2007
Member, Cancer Metastasis Research Center, Houston, TX, 2005 - 2013
Assistant Professor, Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2005 - 2012
Post-doctoral Researcher, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 1998 - 2005
Graduate Student Researcher, University of California Santa Barbara, Santa Barbara, CA, 1991 - 1998
Research Assistant, ImmunoGen, Inc, Cambridge, MA, 1989 - 1991
Administrative Appointments/Responsibilities
Vice Chair of Research, Neurosurgery - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2018 - Present
Chair, Cancer Biology Program Sub-committee for Foreign Applicants, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 2009 - Present
Chair, Cancer Biology Program Sub-committee for Domestic Applicants, UT-GSBS, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 2009 - 2010
American Legion Auxiliary Fellowship Review Committee, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 2007
Poster Reviewer, Cancer Biology Program Student Research Retreat, University of Texas Graduate School of Biomedical Sciences Programs, Houston, TX, 2006
Other Professional Positions
Consultant, Pliant Therapeutics, San Francisco, CA, 2022 - Present
Consultant, Pfizer Neuroscience, Cambridge, MA, 2013
Consultant, Regeneron, Inc, Tarrytown, NY, 2010
Department of Cancer Biology Seminar Series Organizer, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009
Extramural Institutional Committee Activities
Member, Brain Tumor Center Tissue Oversight Committee, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Division of Surgery Basic/Translational Research Committee, The University of Texas MD Anderson Cancer Center, 2023 - Present
Project Lead, Cancer Neuroscience Neurobiology Initiative, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Cancer Neuroscience Steering Committee, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Research Integrity Committee, The University of Texas MD Anderson Cancer Center, 2022 - Present
Chair, Promotion Committee - Post-Doctoral to Instructor, The University of Texas MD Anderson Cancer Center, 2022
Member, Brain Tumor Center Executive Committee, The University of Texas MD Anderson Cancer Center, 2021 - Present
Member, Harvard Medical School External Advisory Board, The University of Texas MD Anderson Cancer Center, 2021
Member, Neurosurgery Faculty Search Committee, The University of Texas MD Anderson Cancer Center, 2019
Member, Steering Committee -The Brain Metastasis Program, The University of Texas MD Anderson Cancer Center, 2017 - Present
Chair, Cancer Biology Program Faculty Membership Committee, The University of Texas MD Anderson Cancer Center, 2017 - 2018
Member, Brain Metastasis, The University of Texas MD Anderson Cancer Center, 2017
Member, Knudsen Dissertation Award Committee, The University of Texas MD Anderson Cancer Center, 2017
Member, GSBS Cancer Biology Program Course Curriculum, The University of Texas MD Anderson Cancer Center, 2017
Member, Faculty Appeals Panel, The University of Texas MD Anderson Cancer Center, 2016 - Present
Member, Igniting Change Across Research (iCAR), The University of Texas MD Anderson Cancer Center, 2016 - 2017
Member, The Big Survey Faculty Working Group, The University of Texas MD Anderson Cancer Center, 2016
Member, Brain Metastasis Committee, The University of Texas MD Anderson Cancer Center, 2016
Member, Multidisciplinary Research Advisory Council, The University of Texas MD Anderson Cancer Center, 2015 - 2018
Member, Grants and Contracts, The University of Texas MD Anderson Cancer Center, 2015 - 2017
Member, Brain Tumor Center Tissue Committee, The University of Texas MD Anderson Cancer Center, 2015
Member, SPORE in Prostate Cancer, The University of Texas MD Anderson Cancer Center, 2013
Member, Alfred G Knutson Award, National Institute of Health, 2012
Member, Basic Research Review Committee, Institutional Research Grant (IRG), The University of Texas MD Anderson Cancer Center, 2009 - 2011
Chair, Cancer Biology Program Sub-committee, The University of Texas MD Anderson Cancer Center, 2009
Member, Review Committee, Odyssey Post-doctoral Fellowship Program, The University of Texas MD Anderson Cancer Center, 2008 - 2011
Member, American Legion Auxiliary Fellowship, The University of Texas MD Anderson Cancer Center, 2007
Editorial Activities
Academic Editor, PLoS One, 2015 - Present
Editorial Board Member, Neuro-Oncology, 2013 - 2020
Honors & Awards
| 2023 | Honoree for Excellence in Research, The University of Texas MD Anderson Cancer Center |
| 2020 | Sigma Xi Scientific Research Honor Society, Sigma Xi Scientific |
| 2009 - 2011 | ARRA Research Grant Award, NIH/NINDS |
| 2008 - 2010 | Career Development Award, MDACC Brain Cancer SPORE |
| 2006 - 2010 | New Scholar Award in Aging, Ellison Medical Foundation |
| 2005 | Nominee for Pew Scholar Program, MD Anderson Cancer Center |
| 2004 - 2005 | Anna Fuller Post-Doctoral Fellow |
| 2003 | Anna Fuller Post-Doctoral Fellow, MIT |
| 1998 - 2003 | Howard Hughes Medical Institute Post-Doctoral Research Associate, MIT |
| 1994 - 1997 | American Heart Association Pre-Doctoral Fellowship, University of California, Santa Barbara |
| 1993 | Pre-Doctoral Scholar Award, Summer Physiology Course, Marine Biological Laboratory, Woods |
| 1991 - 1992 | AmGen Pre-Doctoral Fellowship, University of California, Santa Barbara |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2010. Advances in Oncology Institutional Grand Rounds. Conference. University of Texas M. D. Anderson Cancer Center, US.
- 2009. Advances in Oncology Institutional Grand Rounds. Conference. University of Texas M. D. Anderson Cancer Center, US.
- 2006. Pediatric Grand Rounds. Conference. University of Texas MD Anderson Cancer Center. Houston, TX, US.
Regional Presentations
- 2025. Neurovascular signaling networks in brain hemorrhage development and repair. Invited. Pediatric Research Center. Houston, TX, US.
- 2024. Glial Control of Blood-Brain Barrier Permeability in Glioblastoma. Invited. University of Texas Medical School. Houston, TX, US.
- 2023. Analyzing Mechanisms of Brain Cancer Pathogenesis. Invited. TAMU Engineering and Medical School. Houston, TX, US.
- 2021. Astroglial Control of Cerebrovascular Development and Pathophysiology. Invited. Houston, TX, US.
- 2014. Cell Adhesion and Signaling Pathways in Brain Development and Cancer,. Invited. Houston, TX, US.
- 2014. Mechanisms of Cell Migration and Invasion in the CNS. Invited. College Station, TX, US.
- 2012. Deciphering Angiogenesis in Brain Development and Cancer. Invited. Houston, TX, US.
- 2012. Cell Adhesion and Signaling Pathways in Brain Development and Cancer. Invited. Houston, TX, US.
- 2009. Neurovascular Communication in Brain Development and Cancer. Invited. Integrative Biology and Pharmacology. Houston, TX, US.
- 2006. The Neurovascular Unit and Age-Related Neurodegeneration,. Invited. Huffington Center for Aging. Houston, TX, US.
National Presentations
- 2023. Cell Adhesion and Signaling Pathways in Brain Development and Cancer. Invited. Atlanta, BA, US.
- 2021. Astrocyte-Endothelial Cell Signaling Networks in Brain Development and Disease. Invited. Waltham, MA, US.
- 2019. Glioma Stem Cell Exploitation of the Perivascular Niche. Invited. Ivy Brain Tumor Center. Phoenix, AZ, US.
- 2019. Astrocyte-Endothelial Cell Signaling Pathways in Brain Vascular Development. Invited. Department of Neurobiology. Phoenix, AZ, US.
- 2019. Cell Adhesion and Signaling Pathways in Neurovascular Development. Invited. Department of Physiology. Memphis, TN, US.
- 2019. A Genetically Engineered Mouse Model to Selectively Identify Perivascular Astrocytes in the Brain. Invited. Blood-Brain Carrier Meeting. Laurel Hollow, NY, US.
- 2019. Prion Control of Angiogenesis in the Brain. Invited. Gordon Research Conference on Vascular Cell Biology. Ventura, CA, US.
- 2018. Mechanisms of Perivascular Brain Cancer Cell Invasion. Invited. Vascular Biology Program. Boston, MA, US.
- 2017. αvβ8 Integrin in Glioblastoma Stem Cells Promotes Tumor Initiation and Progression. Invited. Society for Neuro-Oncology Annual Meeting. San Francisco, CA, US.
- 2017. Cell Adhesion and Signaling Pathways that Drive Glioblastoma Cell Invasion,. Invited. Department of Bioengineering/Molecular and Cellular Biology Program/Wills Neuroscience Institute. Berkeley, CA, US.
- 2017. Pathways Linking Angiogenesis and Tumor Cell Invasion in Glioblastoma. Invited. Department of Physiology,. Oklahoma City, OK, US.
- 2015. Integrin Regulation of the Perivascular Niche in Glioblastoma. Invited. Gordon Research Conferences. Newport, RI, US.
- 2015. Deconstructing the Perivascular Niche in Glioblastoma. Invited. Department of Developmental, Molecular and Chemical Biology. Boston, MA, US.
- 2015. Astroglial Control of Angiogenesis in the Developing Brain. Department of Neuroscience. Boston, MA, US.
- 2015. Glial Control of Angiogenesis in the Nervous System. Invited. Gordon Research Conference on Vascular Cell Biology. Ventura, CA, US.
- 2014. Cell Adhesion and Signaling Pathways in Brain Development and Cancer. Invited. Buffalo, NY, US.
- 2013. Blood-Brain Barrier Development, Experimental Biology. Invited. 2013 American Association of Anatomists, Plenary Session on Neurovascular Biology. Boston, MA, US.
- 2013. The Microenvironment in GBM Progression. Invited. Greenbaum Cancer Center. Baltimore, MD, US.
- 2012. αvβ8 Integrin-TGFbeta Signaling in Blood-Brain Barrier Development and Disease. Invited. 2012 Blood-Brain Barrier Meeting. Laurel Hollow, NY, US.
- 2012. Links between Brain Development and Cancer. Invited. San Diego, CA, US.
- 2012. Analysis of the Blood-Brain Barrier in Health and Disease. Invited. Cambridge, MA, US.
- 2012. Neurovascular Communication in Brain Development and Cancer. Invited. Washington, DC, US.
- 2012. Integrin-Mediated Regulation of TGFbeta Activation and Signaling. Invited. Langone Cancer Center. New York, NY, US.
- 2012. The Neurovascular Unit in Development, Physiology and Cancer. Invited. Reynolds Oklahoma Center on Aging. Oklahoma City, OK, US.
- 2011. Cell Adhesion and Signaling Pathways in the Neurovascular Niche. Invited. Gordon Research Conference on Vascular Cell Biology. Ventura, CA, US.
- 2010. Integrins and the ECM in Glioblastoma Angiogenesis. Invited. American Society of Cell Biology 2010 National Meeting. Philadelphia, PA, US.
- 2010. Analysis of Integrin Adhesion and Signaling in Blood-Brain Barrier Development,. Invited. Blood-Brain Barrier Meeting. Laurel Hollow, NY, US.
- 2010. The Neurovascular Unit and Age-Related Neurodegeneration. Invited. The Ellison Medical Foundation Colloquium on the Biology of Aging. Woods Hole, MA, US.
- 2010. Regulation of Brain Tumor Angiogenesis by b8 Integrin. Conference. AACR. Washington, DC, US.
- 2010. Meet the Expert- Cell Adhesion and Signaling Pathways in Glioma Angiogenesis. Invited. AACR. Washington, D.C, US.
- 2010. Angiogenesis in Brain Development and Cancer. Invited. Tarrytown, NY, US.
- 2009. Integrin Regulation of Neurogenesis in the Adult Brain. Conference. Society for Neuroscience. Chicago, IL, US.
- 2009. Analyzing Functional Links between Band 4.1B and Integrins. Conference. Assocation of American Physicians (AAP). Chicago, IL, US.
- 2009. Analyzing αvβ8 Integrin Functions in Mouse and Human Glioma Cells. Conference. AACR. Denver, CO, US.
- 2009. Analzing TGFbeta Receptor Signaling in the Developing and Adult Brain. Conference. AACR, US.
- 2008. Cell Adhesion and Signaling Pathways in Neurovascular Development and Diseases. Invited. Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease. Biddeford, ME, ME, US.
- 2008. Integrin-Mediated Adhesion and Signaling Pathways in Glioma-Induced Angiogenesis. Conference. AACR. San Diego, CA, US.
- 2008. Integrin-Mediated Regulation of Neurogenesis in the Adult Brain. Invited. Experimental Biology 2008. San Diego, CA, US.
- 2006. Cell Adhesion and Signaling at the Blood-Brain Barrier. Invited. Gordon Research Conference on Barriers of the CNS. Tilton, NH, US.
- 2005. Cell Adhesion and Signaling During Neurovascular Development. Invited. NIH/National Eye Institute. Bethesda, MD, US.
- 2005. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Cornell University Medical School. Ithica, NY, US.
- 2005. Cell Adhesion and Signaling in the CNS Microenvironment. Invited. NCI Workshop on Mouse Models of Brain Cancer. St Louis, MO, US.
- 2005. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Cardiology. Ithaca, NY, US.
- 2005. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. University of North Carolina. Chapel Hill, NC, US.
- 2005. Cell Adhesion and Signaling in the CNS Microenvironment. Invited. NCI Workshop on Mouse Models of Brain Cancer. St Louis, MO, US.
- 2005. Cell Adhesion and Signaling at the Neural-Vascular Interface. Invited. Harvard Medical School Vascular Research Division. Boston, MA, US.
- 2005. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Neurosurgery. Salt Lake City, UT, US.
- 2005. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Cell and Molecular Physiology. Chapel Hill, NC, US.
- 2005. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. University of Utah. Salt Lake City, UT, US.
- 2005. Cell Adhesion and Signaling During Neurovascular Development. Invited. National Eye Institute. Bethesda, MD, US.
- 2005. Cell Adhesion and Signaling at the Neural-Vascular Interface. Invited. Harvard Medical School. Boston, MA, US.
- 2004. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Uniformed Services University of the Health Sciences. Bethesda, MD, US.
- 2004. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Cell Biology. Albany, NY, US.
- 2004. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Anatomy and Physiology. Bethesda, MD, US.
- 2004. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Albany Medical College. Albany, NY, US.
- 2004. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. University of Virginia. Charlottesville, VA, US.
- 2003. Cell Adhesion and Signaling During CNS Morphogenesis. Invited. University of California, Santa Barbara. Santa Barbara, CA, US.
- 2003. Cell Adhesion and Signaling Pathways in CNS Morphogenesis. Invited. Cellular, Molecular, and Developmental Biology. Santa Barbara, CA, US.
- 2003. Cell Adhesion and Signaling During Vascular Development in the CNS. Invited. Cardiovascular Research Center. Charlottesville, VA, US.
- 2001. Integrins and CNS Development. Invited. Department of Biochemistry. Waltham, MA, US.
- 2001. Integrins and CNS Development. Invited. Brandeis University. Waltham, MA, US.
- 2000. Cell Adhesion and Signaling Pathways in Neurovascular Development and Diseases. Invited. Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease. Biddenford, ME, US.
International Presentations
- 2012. The Blood-Brain Barrier in Development and Cancer. Invited. International Society for Cell Biology. Rio de Janeiro, BR.
- 2009. 12th International Symposium on "Signaling at the Blood-Brain and Blood-Retinal Barriers". Invited. International Blood-Brain Barrier Society. London, GB.
- 2007. Integrin-Mediated Regulation of Neurovascular Development and Homeostasis. Invited. Cerebral Vascular Biology Society. Ottawa, US.
Grant & Contract Support
| Date: | 2026 - 2031 |
| Title: | Targeting the Extracellular Matrix in Glioma |
| Funding Source: | CPRIT |
| Role: | PI |
| ID: | RP270459 |
| Date: | 2026 - 2031 |
| Title: | Decoding Extracellular Calcium Signaling in Glioblastoma Growth and Invasion |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA323047-01 |
| Date: | 2026 - 2031 |
| Title: | HepaCAM Adhesion and Signaling Pathways in Glioblastoma Cells |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA315912 |
| Date: | 2025 - 2026 |
| Title: | Spatial Profiling of the Extracellular Matrix in Glioblastoma |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | P50CA127001-14 |
| Date: | 2023 - 2024 |
| Title: | Neurovascular Barriers in Cancer |
| Funding Source: | MDACC Cancer Neuroscience Program |
| Role: | PI |
| Date: | 2023 - 2024 |
| Title: | Targeting Fatty Acid Metabolism in Metastatic Brain Cancer |
| Funding Source: | MDACC McDougal Brain Metastasis Research Program |
| Role: | PI |
| Date: | 2023 - 2024 |
| Title: | Targeting the Extracellular Matrix in Glioblastoma |
| Funding Source: | NCI SPORE |
| Role: | PI |
| ID: | 2P50CA127001 |
| Date: | 2023 - 2026 |
| Title: | Targeting the Mlc1-GlialCAM Protein Complex in Invasive Glioma Cells |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP230093 |
| Date: | 2021 - 2026 |
| Title: | Analyzing Adhesion and Signaling Functions for PTPN12 in Invasive Glioma Cells |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1R01NS122052-03 |
| Date: | 2021 - 2026 |
| Title: | Analyzing the Endothelial Cell-Expressed Prion Gene Prnd in Vascular Development |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1R01NS122143-03 |
| Date: | 2021 - 2026 |
| Title: | UTEP/UTMDA Partnership for Hispanic Cancer Disparities Research |
| Funding Source: | University of Texas El Paso |
| Role: | Co-I |
| ID: | RP210153 |
| Date: | 2020 - 2023 |
| Title: | Targeting Endothelial Transcription Networks in Glioblastoma |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-PI |
| ID: | RP200402 |
| Date: | 2020 - 2023 |
| Title: | Modulating Endothelial Transcriptional Networks to Affect Outcomes in GBM |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-PI |
| ID: | 153248 |
| Date: | 2020 - 2025 |
| Title: | Targeting the Blood-Brain Barrier with LITT |
| Funding Source: | Terry L Chandler Foundation |
| Role: | PI |
| ID: | Foundation |
| Date: | 2019 - 2023 |
| Title: | A Transformative Initiative in Glioblastoma |
| Funding Source: | Brockman Foundation |
| Role: | PI |
| ID: | Foundation |
| Date: | 2019 - 2021 |
| Title: | Analyzing Cell-Cell Fusion in Glioblastoma Growth and Progression |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | R21NS103841-02 |
| Date: | 2018 - 2021 |
| Title: | Targeting the Prion Protein Doppel in Brain Tumor Angiogenesis |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP180220 |
| Date: | 2017 - 2019 |
| Title: | Targeting Phosphorylation-Dependent Ubiquitination in Invasive GBM Cells |
| Funding Source: | UTMDACC Brain SPORE Developmental Research Program |
| Role: | PI |
| Date: | 2014 - 2017 |
| Title: | Targeting Tumor Cell Invasion in Glioblastoma |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP140411 |
| Date: | 2014 - 2024 |
| Title: | Signal Transduction by alphaVbeta8 Integrin |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 2R01NS087635-10 |
| Date: | 2014 - 2016 |
| Title: | Genetic Models to Study Glial Regulation of Angiogenesis |
| Funding Source: | NIH/NINDS |
| Role: | Co-PI |
| ID: | 1R21CA182053-01 |
| Date: | 2014 - 2015 |
| Title: | Analyzing Cell-Cell Fusion in Glioblastoma |
| Funding Source: | MDACC, Institutional Research Grant Program |
| Role: | PI |
| Date: | 2012 - 2017 |
| Title: | Deciphering Mechanisms of Tumor Cell Invasion in Glioblastoma |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1-R01-NS078402-01A1 |
| Date: | 2010 - 2012 |
| Title: | Inhibiting the Angiogenic to Invasive Transition in Glioblastoma |
| Funding Source: | NIH/NCI |
| Role: | SPORE Developmental Research Project Leader |
| Date: | 2010 - 2010 |
| Title: | Integrating Integrin and Wnt Signaling in Stem Cell Niches |
| Funding Source: | MDACC, Center for Stem Cell and Developmental Biology |
| Role: | PI |
| Date: | 2009 - 2011 |
| Title: | Analysis of alphaVbeta8 Integrin in Gliomagenesis |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 3-R01-NS059876-02S2 |
| Date: | 2009 - 2009 |
| Title: | Analysis of alphaVbeta8 Integrin in Gliomagenesis |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 3-R01-NS059876-02S1 |
| Date: | 2009 - 2009 |
| Title: | Integrin-Mediated Regulation of Epithelial Cell Growth |
| Funding Source: | American Cancer Society Institutional Research Grant |
| Role: | PI |
| Date: | 2008 - 2010 |
| Title: | Brain Cancer SPORE |
| Funding Source: | NIH/NCI |
| Role: | Career Development Project Leader |
| ID: | P50-CA127001 |
| Date: | 2007 - 2008 |
| Title: | Cell Adhesion and Signaling at the Neural-Vascular Interface |
| Funding Source: | MDACC Institutional Research Grant |
| Role: | PI |
| Date: | 2006 - 2010 |
| Title: | The Neurovascular Unit and Age-Related Neurodegeneration |
| Funding Source: | Ellison Medical Foundation |
| Role: | PI |
| Date: | 2006 - 2007 |
| Title: | The Neurovascular Unit and Brain Cancer Metastases |
| Funding Source: | MDACC, Cancer Metastasis Research Center |
| Role: | PI |
| Date: | 2005 - 2008 |
| Title: | Integrin-ECM Adhesion and Signaling at the Neurovascular Unit |
| Funding Source: | M. D. Anderson Cancer Center New Faculty Start-up Award |
| Role: | PI |
Selected Publications
Peer-Reviewed Articles
- Wahab, R, Keshavarz, A, Azam, Z, Islam, T, Hasan, MM, Zhang, XJ, Alobaida, A, Rana, M, Choi, JU, Alam, F, Kim, IS, Byun, Y, McCarty, J, Nickel, NP, Roy, S, Al-Hilal, TA. Microfluidic captured patient-derived circulating endothelial cells identify novel targets of pulmonary arterial hypertension. Biomaterials 323, 2025. e-Pub 2025. PMID: 40408976.
- De A, Foreno S, Morales JE, Sebastian S, Granada M, Weinberg J, Ballester L, Lang FF, Akdemir K, McCarty JH. Single-Cell Spatial Profiling of the Matrisome Gene Expression in Human Glioblastoma. e-Pub 2025.
- Nassir-Toosi, Forero, Morales, Sebastian, Chen, De, McCarty. GlialCAM Cytoplasmic Signaling in Astrocytes and Oligodendrocytes is Essential White Matter Homeostasis in the Adult Brain. e-Pub 2025.
- Forero, Chen, De, Morales, Wise, McCarty. Single Cell Profiling of Brain Hemorrhage Initiation and Repair. Angiogenesis. Nature Comm. Biol. e-Pub 2025.
- Kim S, Chen Z, Morales JE, McCarty JH. Prnd/Doppel in endothelial cells is required for neurovascular repair after stroke. e-Pub 2024.
- Sebastian S, De A, Morales JE, Chen Z, McCarty JH. The Fraser Syndrome Protein Frem1 Regulates Blood-Brain Barrier Maturation and Physiology. e-Pub 2024.
- Roby KC, De A, Morales JE, Kelly JR, Sebastian S, Zheng X, Huse JT, McCarty JH. Sub-populations of Glioma Associated Astrocytes Promote Tumor Growth and Progression via Brevican Deposition in the Extracellular Matrix. e-Pub 2024.
- De A, Lattier JM, Morales JE, Kelly JR, Zheng X, Chen Z, Sebastian S, Nassiri Toosi Z, Huse JT, Lang FF, McCarty JH. Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma. J Neurosci 43(47):8043-8057, 2023. e-Pub 2023. PMID: 37722850.
- McCarty JH. MMP9 Clears the Way for Metastatic Cell Penetration Across the Blood-Brain Barrier. Cancer Res 83(8):1167-1169, 2023. e-Pub 2023. PMID: 37057598.
- Chen Z, Kelly JR, Morales JE, Sun RC, De A, Burkin DJ, McCarty JH. The alpha7 integrin subunit in astrocytes promotes endothelial blood-brain barrier integrity. Development 150(6), 2023. e-Pub 2023. PMID: 36960827.
- De A, Morales JE, Chen Z, Sebastian S, McCarty JH. The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development. Development 149(6), 2022. e-Pub 2022. PMID: 35217866.
- Morales JE, De A, Miller AA, Chen Z, McCarty JH. Mlc1-Expressing Perivascular Astrocytes Promote Blood-Brain Barrier Integrity. J Neurosci 42(8):1406-1416, 2022. e-Pub 2022. PMID: 34965971.
- Catignas KK, Frick LR, Pellegatta M, Hurley E, Kolb Z, Addabbo K, McCarty JH, Hynes RO, van der Flier A, Poitelon Y, Wrabetz L, Feltri ML. αV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo. Glia 69(1):91-108, 2021. e-Pub 2021. PMID: 32744761.
- Lattier JM, De A, Chen Z, Morales JE, Lang FF, Huse JT, McCarty JH. Megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) promotes glioblastoma cell invasion in the brain microenvironment. Oncogene 39(50):7253-7264, 2020. e-Pub 2020. PMID: 33040087.
- Chen Z, Morales JE, Avci N, Guerrero PA, Rao G, Seo JH, McCarty JH. The vascular endothelial cell-expressed prion protein doppel promotes angiogenesis and blood-brain barrier development. Development 147(18), 2020. e-Pub 2020. PMID: 32895288.
- Yosef N, Xi Y, McCarty JH. Isolation and transcriptional characterization of mouse perivascular astrocytes. PLoS One 15(10):e0240035, 2020. e-Pub 2020. PMID: 33031376.
- Lattier, J M, Chen, Z, De, A, Morales, J E, and McCarty J H. MLC1, an Astrocyte-Expressed Gene Linked to Neurovascular Development, Promotes Glioblastoma Cell Invasion in the Brain Microenvironment. Oncology, 2020. e-Pub 2020. PMID: 33040087.
- Chen Z, Morales JE, Guerrero PA, Sun H, McCarty JH. PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells. Cancer Res 78(14):3809-3822, 2018. e-Pub 2018. PMID: 29743287.
- Tiwary S, Morales JE, Kwiatkowski SC, Lang FF, Rao G, McCarty JH. Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a. Sci Rep 8(1):8267, 2018. e-Pub 2018. PMID: 29844613.
- Guerrero PA, Tchaicha JH, Chen Z, Morales JE, McCarty N, Wang Q, Sulman EP, Fuller G, Lang FF, Rao G, McCarty JH. Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression. Oncogene 36(47):6568-6580, 2017. e-Pub 2017. PMID: 28783169.
- Toutounchian JJ, McCarty JH. Selective expression of eGFP in mouse perivascular astrocytes by modification of the Mlc1 gene using T2A-based ribosome skipping. Genesis 55(10), 2017. e-Pub 2017. PMID: 28929580.
- Clements TP, Tandon B, Lintel HA, McCarty JH, Wagner DS. RICE CRISPR: Rapidly increased cut ends by an exonuclease Cas9 fusion in zebrafish. Genesis 55(8), 2017. e-Pub 2017. PMID: 28653435.
- Kwiatkowski SC, Guerrero PA, Hirota S, Chen Z, Morales JE, Aghi M, McCarty JH. Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy. PLoS One 12(9):e0185065, 2017. e-Pub 2017. PMID: 28938007.
- Cheerathodi M, Avci NG, Guerrero PA, Tang LK, Popp J, Morales JE, Chen Z, Carnero A, Lang FF, Ballif BA, Rivera GM, McCarty JH. The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma. Mol Cancer Res 14(12):1277-1287, 2016. e-Pub 2016. PMID: 27655131.
- Hirota S, Clements TP, Tang LK, Morales JE, Lee HS, Oh SP, Rivera GM, Wagner DS, McCarty JH. Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain. Development 142(24):4363-73, 2015. e-Pub 2015. PMID: 26586223.
- Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, Saunus J, Lakhani S, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 527(7576):100-104, 2015. e-Pub 2015. PMID: 26479035.
- Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, Paidassi H, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH. Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol 35(8):1401-13, 2015. e-Pub 2015. PMID: 25666508.
- Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene 34(4):516-24, 2015. e-Pub 2015. PMID: 24469034.
- Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med 19(12):1617-24, 2013. e-Pub 2013. PMID: 24216753.
- Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF. The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell 24(24):3857-68, 2013. e-Pub 2013. PMID: 24152735.
- McCarty JH. Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET?. Clin Cancer Res 19(7):1631-3, 2013. e-Pub 2013. PMID: 23403631.
- Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH. αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. Mol Biol Cell 24(4):474-82, 2013. e-Pub 2013. PMID: 23283986.
- Jung Y, McCarty JH. Band 4.1 proteins regulate integrin-dependent cell spreading. Biochem Biophys Res Commun 426(4):578-84, 2012. e-Pub 2012. PMID: 22982319.
- Mobley AK, McCarty JH. Cre-Lox genetic strategies to selectively delete cell adhesion genes in astrocytes. Methods in Molecular Biology 814:555-70, 2012. e-Pub 2012.
- Allinson KR, Lee HS, Fruttiger M, McCarty JH, Arthur HM. Endothelial expression of TGFβ type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system. PLoS One 7(6):e39336, 2012. e-Pub 2012. PMID: 22745736.
- Hirota S, Liu Q, Lee HS, Hossain MG, Lacy-Hulbert A, McCarty JH. The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina. Development 138(23):5157-66, 2011. e-Pub 2011. PMID: 22069187.
- Nguyen HL, Lee YJ, Shin J, Lee E, Park SO, McCarty JH, Oh SP. TGFβ signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development. Lab Invest 91(11):1554-63, 2011. e-Pub 2011. PMID: 21876535.
- Mobley AK, McCarty JH. β8 integrin is essential for neuroblast migration in the rostral migratory stream. Glia 59(11):1579-87, 2011. e-Pub 2011. PMID: 21674628.
- Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH. Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin. Cancer Res 71(20):6371-81, 2011. e-Pub 2011. PMID: 21859829.
- Hsu A, Esmaeli B, Hayek B, Hossain MG, Shinder R, Lazar AJ, McCarty JH. Analysis of αv Integrin Protein Expression in Human Eyelid and Periorbital Squamous Cell Carcinomas. J Cutan Pathol 38(7):570-5, 2011. e-Pub 2011. PMID: 21375561.
- Khan S, Lakhe-Reddy S, McCarty JH, Sorenson CM, Sheibani N, Reichardt LF, Kim JH, Wang B, Sedor JR, Schelling JR. Mesangial cell Integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1. Am J Pathol 178(2):609-20, 2011. e-Pub 2011. PMID: 21281793.
- Jung Y, Kissil JL, McCarty JH. β8 Integrin and Band 4.1B Cooperatively Regulate Morphogenesis of the Embryonic Heart. Dev Dyn 240(1):2717-7, 2011. e-Pub 2011. PMID: 21181944.
- Tchaicha JH, Mobley AK, Hossain MG, Aldape KD, McCarty JH. A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis. Oncogene 29(31):4460-72, 2010. e-Pub 2010. PMID: 20531304.
- Langley RR, Fan D, Guo L, Zhang C, Lin Q, Brantley EC, McCarty JH, Fidler IJ. Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis. Int J Oncol 35(4):665-672, 2009. e-Pub 2009. PMID: 19724901.
- Workshop Collaborators. Biology of vascular malformations in the brain. Stroke, 2009. e-Pub 2009. PMID: 19834013.
- Mobley AK, Tchaicha JH, Shin J, Hossain MG, McCarty JH. beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain. J Cell Sci 122(11):1842-1851, 2009. e-Pub 2009. PMID: 19461074.
- McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO. Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol 172(6):1740-7, 2008. e-Pub 2008. PMID: 18467691.
- Yi C, McCarty JH, Troutman SA, Eckman MS, Bronson RT, Kissil JL. Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer. Mol Cell Biol 25(22):10052-9, 2005. e-Pub 2005. PMID: 16260618.
- McCarty JH, Cook AA, Hynes RO. An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain. Proc Natl Acad Sci U S A 102(38):13479-83, 2005. e-Pub 2005. PMID: 16157875.
- McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Roes J, Hynes RO. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development 132(1):165-76, 2005. e-Pub 2005. PMID: 15576410.
- McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, Dvorak AM, Hynes RO. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol 22(21):7667-77, 2002. e-Pub 2002. PMID: 12370313.
- McCarty JH, Feinstein SC. The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL. J Recept Signal Transduct Res 19(6):953-74, 1999. e-Pub 1999. PMID: 10533983.
- McCarty JH, Feinstein SC. Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction. Oncogene 16(13):1691-700, 1998. e-Pub 1998. PMID: 9582017.
- Esmaeli-Azad B, McCarty JH, Feinstein SC. Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability. J Cell Sci 107 ( Pt 4):869-79, 1994. e-Pub 1994. PMID: 8056843.
Invited Articles
- Lee HS, McCarty JH. Inducible gene deletion in glial cells to study angiogenesis in the central nervous system. Methods Mol Biol 1135:261-74, 2014. e-Pub 2014. PMID: 24510871.
- Mobley AK, McCarty JH. Use of Cre-lox technology to analyze integrin functions in astrocytes. Methods Mol Biol 814:555-70, 2012. e-Pub 2012. PMID: 22144332.
- McCarty JH. Cell adhesion and signaling networks in brain neurovascular units. Curr Opin Hematol 16(3):209-214, 2009. e-Pub 2009. PMID: 19318941.
- McCarty JH. Integrin-mediated regulation of neurovascular development, physiology and disease. Cell Adh Migr 3(2):211-215, 2009. e-Pub 2009. PMID: 19372738.
- McCarty JH. Alphav integrins lead the way for colorectal metastases. Clin Cancer Res 14(20):6351-3, 2008. e-Pub 2008. PMID: 18927272.
- McCarty JH. Cell biology of the neurovascular unit: implications for drug delivery across the blood-brain barrier. Assay Drug Dev Technol 3(1):89-95, 2005. e-Pub 2005. PMID: 15798399.
- Hynes RO, Lively JC, McCarty JH, Taverna D, Francis SE, Hodivala-Dilke K, Xiao Q. The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harb Symp Quant Biol 67:143-53, 2002. e-Pub 2002. PMID: 12858535.
Review Articles
- McCarty JH. αvβ8 integrin adhesion and signaling pathways in development, physiology and disease. J Cell Sci 133(12), 2020. e-Pub 2020. PMID: 32540905.
- Ferguson SD, Zheng S, Xiu J, Zhou S, Khasraw M, Brastianos PK, Kesari S, Hu J, Rudnick J, Salacz ME, Piccioni D, Huang S, Davies MA, Glitza IC, Heymach JV, Zhang J, Ibrahim NK, DeGroot JF, McCarty J, O'Brien BJ, Sawaya R, Verhaak RG, Reddy SK, Priebe W, Gatalica Z, Spetzler D, Heimberger AB. Profiles of brain metastases: Prioritization of therapeutic targets. IJC:3019 - 3026, 2018. e-Pub 2018.
- Guerrero PA, McCarty JH. Integrins in Vascular Development and Pathology. Adv Pharmacol 81:129-153, 2018. e-Pub 2018. PMID: 29310797.
- McCarty JH. The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events. Bioessays 20(11):913-21, 1998. e-Pub 1998. PMID: 9872057.
Abstracts
- Kim,S, McCarty, JH. Roles for Prnd in Endothelial Cells in Stroke Recovery.
- Tchaicha JH, Mobley AK, Hossain MG, McCarty JH. Integrin-Mediated Adhesion and Signaling Pathways in Glioma-Induced Angiogenesis,. AACR.
- Shin S, McCarty JH. Analyzing TGF Receptor Signaling in the Developing and Adult Brain. AACR.
- Tchaicha JH, McCarty JH. Analyzing αvβ8 Integrin Functions in Mouse and Human Glioma Cells. AACR.
- Jung Y, McCarty JH. Analyzing Functional Links between Band 4.1B and Integrins. Association of American Physicians (AAP), American Society for Clinical Investigation (ASCI.
- Mobley AK, McCarty JH. Integrin Regulation of Neurogenesis in the Adult Brain, Society for Neuroscience. Society of Neuroscience.
- Tchaicha JH, McCarty, JH. Regulation of Brain Tumor Angiogenesis by 8 Integrin. AACR.
- Reyes SB, McCarty JH. v8 Integrin Regulates RhoGDI1 Activation and Rho GTPase Signaling in Invasive Glioblastoma Cells. M.D. Anderson Graduate Research Symposium.
- Hirota S, McCarty JH. Neuropilin Control of Sprouting Angiogenesis in the Brain, Angiogenesis. Gordon Research Conference.
- Lattier JM, McCarty JH. Functions for the Mlc1-GlialCAM Signaling Complex in the Glioma Vascular Niche. M.D. Anderson 5th Annual Postdoctoral Science Symposium.
- Batra N, McCarty JH. The Prion Protein Doppel Controls Angiogenesis in the Developing Brain and in Malignant Brain Tumors. M.D. Anderson 5th Annual Postdoctoral Science Symposium.
- Batra N, McCarty JH. The Prion Protein Doppel Controls Angiogenesis in the Developing Brain and in Malignant Brain Tumors. The Hallmarks of Cancer.
- Tiwary S, McCarty, JH. Co-option of the Blood-Brain Barrier by Metastatic Tumor Cells. M.D. Anderson 6th Annual Postdoctoral Science Symposium.
- Lattier, JM, McCarty, JH. GlialCAM and Mlc1 Interact to Regulate Glioblastoma White Matter Invasion. M.D. Anderson 6th Annual Postdoctoral Science Symposium.
- Yosef, N, McCarty, JH. Characterization of Perivascular Astrocytes in the Brain using a Novel Fluorescent Mouse Model. M.D. Anderson 10th Annual Postdoctoral Science Symposium.
Book Chapters
- Guerrero, PA, McCarty JH. In: Integrins in Vascular Development and Pathology. in Advances in Vascular Pharmacology: The Cytoskeleton and Extracellular Matrix, 2017.
- McCarty JH. In: Src homology 2 domains. In Encyclopedia Reference of Cancer, Springer Verlaag, 2016.
- Guerrero, PA, McCarty, JH. In: TGF Activation and Signaling in Angiogenesis. In Angiogenesis, InTech Open Science, 2016.
- Cheerathodi M, McCarty JH. In: Angiogenesis in Gliomas. In Glioma Cell Biology, Springer, 2014.
- McCarty JH, Hynes RO. In: Integrins and the vascular endothelium. In Endothelial Biomedicine. Aird, W. (editor), Cambridge University Press, 2007.
- McCarty JH, Hynes RO. In: Integrins and formation of the microvasculature. In Encyclopedia of the Microvasculature. Shepro, D. (editor), Elsevier Academic Press, 2004.
Patient Reviews
CV information above last modified August 17, 2026