Joshua Niedzielski, Ph.D.
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Associate Faculty Member, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center/Health Science Center at Houston, Houston, Texas
Assistant Professor, Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Faculty Member, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center/Health Science Center at Houston, Houston, Texas
Assistant Professor, Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2016 | The University of Texas-Health Science Center, Houston, Texas, US, Medical Physics, Ph.D |
| 2010 | Michigan State University, East Lansing, Michigan, US, Physics, BS |
| 2009 | Michigan State University, East Lansing, Michigan, US, Astrophysics and Mathematics, BS |
Postgraduate Training
| 2019-2021 | Clinical Residency, Radiation Physics, The University of Texas - MD Anderson Cancer Center, Houston, Texas |
| 2017-2019 | Research Postdoctoral Fellowship, Imaging Physics, The University of Texas - MD Anderson Cancer Center, Houston, Texas |
| 2016-2017 | Research Postdoctoral Fellowship, Radiation Physics, University of Colorado - Anschutz Medical Campus, Aurora, Colorado |
Licenses & Certifications
| 2022 | Texas Medical Board |
| 2022 | American Board of Radiology |
Experience & Service
Other Professional Positions
Chief Resident in Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2021
Intramural Institutional Committee Activities
Member, Ethos Deployment Workgroup, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, New Technology Committee, The University of Texas MD Anderson Cancer Center, 2023 - 2025
Lead, Lattice Radiation Therapy Implementation Workgroup, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, MRI Utilization Workgroup, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Seminar Series Committee, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Compression Belt Implementation Working Group, The University of Texas MD Anderson Cancer Center, 2022 - 2024
Member, CT-on-Rails Replacement Workgroup, The University of Texas MD Anderson Cancer Center, 2022 - 2023
Extramural Institutional Committee Activities
Member, Spatially Fractionated Radiotherapy Working Group, Particle Therapy Co-Operative Group, 2025 - Present
Member, Spatially Fractionated Radiotherapy Working Group, American Association of Physicists in Medicine, 2025 - Present
Specialty Consultant, IAEA Clinical Trial for Spatially Fractionated Radiotherapy Working Group, International Atomic Energy Agency, 2024 - Present
Member, SFRT and FLASH Working Group, Radiosurgery Society, 2024 - Present
Full Member, Machine Intelligence Subcommittee, American Association of Physicists in Medicine, 2021 - Present
Member, FUTURE Research Working Group, American Association of Physicists in Medicine, 2019 - 2021
Member, Student and Trainee Research Working Group, American Association of Physicists in Medicine, 2018 - 2022
Member (Non-voting), Task Group 324 on Respiratory Motion Management, American Association of Physicists in Medicine, 2018 - Present
Honors & Awards
| 2025 - Present | NIH/NCI L30 Loan Repayment Program, The University of Texas MD Anderson Cancer Center |
| 2020 | Chief Resident in Radiation Physics, The University of Texas MD Anderson Cancer Center |
| 2018 - 2020 | AAPM Science Council Mentoring Program, AAPM |
| 2015 | AAPM Young Investigator Competition Finalist, AAPM |
| 2013 | Andrew Sowell-Wade Huggins Scholarship Award, The University of Texas MD Anderson Cancer Center |
| 2010 | MSU College of Natural Science Research Award, Michigan State University |
| 2009 | UBM Research Grant, Michigan State University |
| 2007 | Hebert Graham Scholarship Award, Michigan State University |
| 2007 | SMART Grant, Michigan State University |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2026. Proton-Based Spatially Fractionated Radiation Therapy at MD Anderson: A Roadmap for the Near Future. Invited. Radiation Oncology Proton, Physics, Planning and Outcomes (PPPO) Session. Houston, Texas, US.
- 2025. Back to the Future and Beyond: Spatially Fractionated RT at MD Anderson Cancer Center. Invited. Medical Physics Seminar. Houston, Texas, US.
National Presentations
- 2026. End-to-End Automatic Cardiotoxicity Risk Management for Lung Cancer: Substructure Segmentation, Risk Prediction, and Personalized Plan Optimization. Poster. AAPM Spring Clinical Meeting 2026. Orlando, Fl, US.
- 2023. Radiogenomics and Artificial Intelligence for Personalized Medicine: Perspectives from a Biologist, Physicist and Physician. Conference. AAPM Annual Meeting. Houston, TX, US.
- 2021. Adaptive SBRT for Liver and Pancreas Patients. Conference. 2021 AAPM Virtual 63rd Annual Meeting. Houston, TX, US.
- 2021. Towards Daily Online Adaptive SBRT for Pancreatic Cancer: Dosimetric Analysis of Daily Adaptive Re-Planning Using Re-Optimization and Dose Escalation Techniques. Conference. 2021 AAPM Virtual 63rd Annual - Virtual Meeting. Houston, TX, US.
International Presentations
- 2025. Spatially Fractionated Radiation Therapy. Invited. Motivation & Radiobiological Characteristics of Clinical GRID and Lattice Radiation Therapy Conference symposium. Vienna, US.
Grant & Contract Support
| Date: | 2025 - Present |
| Title: | Hyperpolarized Xenon-129 MRI as a predictive biomarker for mitigating radiation-induced lung injury |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1-K23-HL175243-01A1 |
| Date: | 2025 - 2026 |
| Title: | Functional Avoidance Radiation Therapy using Quantitative MRI |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1-L30-CA305700-01 |
| Date: | 2025 - 2026 |
| Title: | Hyperpolarized 129Xe Gas MRI as a predictive imaging biomarker of radiation-induced lung toxicity from non-small cell lung cancer treatment |
| Funding Source: | MD Anderson Cancer Center |
| Role: | PI |
| ID: | Institutional Research Grant |
| Date: | 2025 - 2027 |
| Title: | Longitudinal hyperpolarized Xenon-129 MRI as an imaging biomarker of radiation pneumonitis from lung cancer radiotherapy |
| Funding Source: | Dept. of Defense-Lung Cancer Research Program |
| Role: | PI |
| ID: | FP00022846 |
| Date: | 2024 - 2029 |
| Title: | Hyperpolarized Xenon-129 MRI as a predictive biomarker for mitigating radiation-induced lung injury |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1-K23-HL175243-01 |
| Date: | 2023 - 2025 |
| Title: | Leveraging Artificial Intelligence for daily online adaptive dose-escalated radiation therapy of pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1-R21-CA280165-01 |
| Date: | 2023 - 2026 |
| Title: | Artificial Intelligence driven approach for daily online adaptive dose-escalated stereotactic body radiation therapy for pancreatic cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP230248 |
| Date: | 2022 - 2024 |
| Title: | Dose Prediction and Knowledge-Based Planning Approach for Automated Clinical Decision Making in Pancreatic Cancer |
| Funding Source: | MDA/Dept. of Radiation Physics |
| Role: | PI |
| Date: | 2022 - 2025 |
| Title: | Treatment Outcome Monitor (TOM): A Lightweight Cloud-Based Tool for Collecting Patient Outcomes |
| Funding Source: | Innovation in Cancer Informatics |
| Role: | Co-PI |
| ID: | ICI |
| Date: | 2022 - 2027 |
| Title: | The interplay between immunotherapy, concurrent chemoradiation and therapy induced senescence on cardiopulmonary adverse events in lung cancer patients |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01, NIH/NCI, FP00015861 |
| Date: | 2022 - 2025 |
| Title: | Novel approach for daily online adaptive dose-escalated stereotactic body radiation therapy for pancreatic cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP220223 |
| Date: | 2020 - 2021 |
| Title: | ROSI Non-Faculty Seed Grant |
| Funding Source: | ROSI Non-Faculty Seed Grant |
| Role: | PI |
| Date: | 2020 - 2021 |
| Title: | Mark-III 129Xe Gas Polarizer System |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | S10/OD027038-01A1 |
| Date: | 2019 - 2025 |
| Title: | Remote Peer Review System |
| Funding Source: | Varian Alliance |
| Role: | Co-I |
Selected Publications
Peer-Reviewed Articles
- Lin, R, Chen, M, Zhang, X, Xu, T, Xu, T, Maguire, RC, Corrigan, KL, Koutroumpakis, E, Chang, JY, Lin, SH, Chen, A, Nguyen, Q, Gandhi, S, Ning, M, Bronk, JK, Chun, SG, Ajdari, A, Niedzielski, JS, Yang, J, Chen, X, Pan, T, Meng, QH, Tsao, A, Deswal, A, Mohan, R, Liao, Z. Bayesian Learning to Reduce Cardiac Risk of Patients With Locally Advanced Non-Small Cell Lung Cancer Based on Personalized Radiation Therapy Prescription. International Journal of Radiation Oncology Biology Physics 125(3):949-958, 2026. e-Pub 2026. PMID: 41365476.
- Chang, E, Holliday, EB, Szklaruk, J, Erwin, WD, Ludmir, EB, Noticewala, SS, Das, P, Koong, A, Minsky, B, Smith, GL, Sawakuchi, GO, Martin-Paulpeter, RM, Niedzielski, JS, Perles, LA, Beddar, S, Valino, VS, Nguyen, JL, Raghav, KS, Javle, M, Kaseb, A, Dasari, AN, Overman, MJ, Parseghian, C, Odisio, BC, Mahvash, A, Kuban, JD, Shen, SE, Wang, XS, Gupta, AC, Al Taie, MM, Brock, K, Tzeng, CD, Vauthey, JN, Wong, FC, Koay, EJ. Single-photon emission computed tomography functional liver imaging to facilitate reirradiation for liver malignancies. JHEP Reports 8(4), 2026. e-Pub 2026. PMID: 41825097.
- Bankson JA, Niedzielski JS, Harlan CJ, Chen Y, Walker CM, Lorenzi PL, Tan L, Kundra V, Merritt ME, Ragavan M, Schellingerhout D, He R, Ding Y, Datar S, Wang Q, Peterson CB, Fuller CD, Sandulache VC, Lai SY. Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer. Magn Reson Med 96(2):826-838, 2026. PMID: 41876436.
- Chen X, Zhang X, Xu T, Mohan R, Lin R, Chen M, Maguire RC, Zhao Y, Koutroumpakis E, Palaskas NL, Deswal A, Ajdari A, Niedzielski JS, Shete SS, Court LE, Yang J, Liao Z. Radiation doses to cardiac substructures predict elevation in high-sensitivity cardiac troponin T (hs-cTnT) levels in radiotherapy for lung cancer. Int J Radiat Oncol Biol Phys 124(4):1124-1136, 2026. e-Pub 2026. PMID: 41110579.
- Martin-Paulpeter, RM, Balter, PA, Perles, LA, Ludmir, EB, Niedzielski, JS. Respiratory motion effects and plan robustness for lattice radiation therapy. Frontiers in Oncology 16:1731981, 2026. e-Pub 2026. PMID: 41821887.
- Alexandra Leone, Christine B Peterson, Anna Lee, Adam S Garden, Gary Brandon Gunn, Lauren Layer Mayo, Amy Catherine Moreno, Steven Jay Frank, Clifton Fuller, Jay P Reddy, Karen Hoffman, Ivan Vazquez, Ming Yang, Joshua Scott Niedzielski, Laurence Edward Court, Thomas J. Whitaker. Defining a Quantitative Threshold for Adaptive Re-planning using a Percentile-based Scoring System. Int J Part Ther 19(101305), 2026. e-Pub 2026. PMID: 41737863.
- Li Y, Martin-Paulpeter RM, Chung CV, Aguilar MA, Matias CM, Delgado A, Nair SS, Court LE, Perles L, Sahoo N, Zhu RX, Poenisch F, Flint DB, Sawakuchi GO, Beddar S, Koay E, Baker JS, Ludmir EB, Niedzielski JS. Novel pencil-beam scanning proton lattice radiation therapy for the treatment of bulky liver cancer: dosimetric comparison with VMAT-lattice radiotherapy. Front Oncol 15:1-10, 2026. e-Pub 2026. PMID: 41716710.
- Benjamin Abraham Insley, Brett Bocian, Sam Beddar, Reza Reiazi, Patrick James Jensen, Rachael M. Martin-Paulpeter, Joshua Scott Niedzielski, David B Flint, Gabriel Oliveira Sawakuchi, Luis Augusto Perles. Monte Carlo simulations of geometric deformation of Harrison–Anderson–Mick applicators used in intraoperative radiation therapy. J Appl Clin Med Phys 26(12):e70386, 2025. e-Pub 2025. PMID: 41306071.
- Chung CV, Nair SS, Khan MS, Nguyen CI, Martin-Paulpeter RM, Ludmir EB, Court LE, Niedzielski JS. Novel Volumetric Modulated Arc Therapy Approach for Lattice Radiation Therapy for Bulky Liver Tumors. Frontiers in Oncology 15, 2025. e-Pub 2025. PMID: 41244915.
- Nair, S, Salazar, RM, Xu, T, Leone, A, Liao, Z, Court, LE, Niedzielski, JS. Multiomic random forest toxicity modeling of radiation esophagitis. Physics and Imaging in Radiation Oncology 36:100838, 2025. e-Pub 2025. PMID: 41078961.
- Nair, SS, Salazar, RM, Xu, T, Leone, A, Liao, Z, Court, LE, Niedzielski, JS. Multiomic based Bayesian network toxicity modeling for simultaneous prediction of multiple toxicity outcomes in NSCLC. Radiotherapy and Oncology 210:111011, 2025. e-Pub 2025. PMID: 40609866.
- Chen, X, Ding, Y, Weng, JK, Wu, CC, Zhao, Y, Sobremonte, A, Mohammedsaid, M, Xu, Z, Zhang, X, Niedzielski, JS, Shete, S, Court, LE, Liao, Z, Wang, J, Subashi, ED, Lee, PP, Yang, J. Deep Learning-Based Cardiac Chamber Segmentation in Magnetic Resonance-Guided Adaptive Radiation Therapy. Advances in Radiation Oncology 10(9), 2025. e-Pub 2025. PMID: 40808698.
- Ger, R, Lentz, JM, Niedzielski, JS, Vora, S, Bues, M, Hernandez Morales, D, Anderson, JD, Kutyreff, CJ, Schulz, CA, Lara, PR, Ridgway, AK, Lemish, PR, Gagneur, JD, Anand, A. Dosimetric Advantage of Scanning Beam Proton Therapy in Gynecologic Patients Receiving Adjuvant Radiotherapy. Cancers 17(12), 2025. e-Pub 2025. PMID: 40563662.
- Baroudi, H, Che Fru, L, Schofield, D, Roniger, DL, Nguyen, C, Hancock, D, Chung, CV, Beadle, BM, Gifford, KA, Netherton, T, Niedzielski, JS, Melancon, AD, Muruganandham, M, Khan, M, Shaitelman, SF, Shete, S, Murina, P, Venencia, D, Thengumpallil, S, Vrieling, C, Zhang, J, Mitchell, MP, Court, LE. An automated treatment planning portfolio for whole breast radiotherapy. Medical physics 52(3):1779-1788, 2025. e-Pub 2025. PMID: 39699058.
- Salazar, RM, Nair, SS, Leone, A, Xu, T, Mumme, R, Duryea, J, De, BS, Corrigan, KL, Rooney, MK, Ning, M, Das, P, Holliday, EB, Liao, Z, Court, LE, Niedzielski, JS. Performance Comparison of 10 State-of-the-Art Machine Learning Algorithms for Outcome Prediction Modeling of Radiation-Induced Toxicity. Advances in Radiation Oncology 10(2), 2025. e-Pub 2025. PMID: 39717195.
- Chung, CV, Nair, S, Khan, M, Nguyen, CI, Martin-Paulpeter, RM, Ludmir, EB, Court, LE, Niedzielski, JS. Novel volumetric modulated arc therapy approach for lattice radiation therapy for bulky liver tumors. Frontiers in Oncology 15, 2025. e-Pub 2025. PMID: 41244915.
- Chen, X, Zhao, Y, Baroudi, H, El Basha, MD, Daniel, A, Gay, SS, Yu, C, Wang, H, Phan, J, Choi, S, Goodman, C, Zhang, X, Niedzielski, JS, Shete, S, Court, LE, Liao, Z, Löfman, F, Balter, PA, Yang, J. Comparison of Vendor-Pretrained and Custom-Trained Deep Learning Segmentation Models for Head-and-Neck, Breast, and Prostate Cancers. Diagnostics 14(24), 2024. e-Pub 2024. PMID: 39767212.
- Martin, RM, Jensen, PJ, Perles, LA, Sawakuchi, GO, Das, P, Koay, EJ, Koong, A, Ludmir, EB, Niedzielski, JS, Beddar, S. Daily Diagnostic Quality Computed Tomography-on-Rails (CTOR) Image Guidance for Abdominal Stereotactic Body Radiation Therapy (SBRT). Cancers 16(22), 2024. e-Pub 2024. PMID: 39594725.
- Chen X, Weng JK, Sobremonte A, Lee BM, Hughes NW, Mohammedsaid M, Zhao Y, Wang X, Zhang X, Niedzielski JS, Shete S, Court LE, Liao Z, Lee PP, Yang J. Case Report: Cardiac neuroendocrine carcinoma and squamous cell carcinoma treated with MR-guided adaptive stereotactic radiation therapy. Front Oncol 16(14):1411474, 2024. e-Pub 2024. PMID: 39351356.
- Leone, AO, Mohamed, AS, Fuller, C, Peterson, CB, Garden, AS, Lee, A, Mayo, LL, Moreno, AC, Reddy, JP, Hoffman, K, Niedzielski, JS, Court, LE, Whitaker, TJ. A Visualization and Radiation Treatment Plan Quality Scoring Method for Triage in a Population-Based Context. Adv Radiat Oncol 9(8):101533, 2024. e-Pub 2024. PMID: 38993196.
- Chang, E, Wong, FC, Chasen, B, Erwin, WD, Das, P, Holliday, EB, Koong, A, Ludmir, EB, Minsky, B, Noticewala, SS, Smith, GL, Taniguchi, C, Rodriguez, MJ, Beddar, S, Martin, RM, Niedzielski, JS, Sawakuchi, GO, Schueler, E, Perles, LA, Xiao, L, Szklaruk, J, Park, PC, Dasari, NV, Kaseb, A, Kee, BK, Lee, SS, Overman, MJ, Willis, JA, Wolff, RA, Tzeng, CD, Vauthey, JN, Koay, EJ. Phase I trial of single-photon emission computed tomography-guided liver-directed radiotherapy for patients with low functional liver volume. JNCI Cancer Spectrum 8(3), 2024. e-Pub 2024. PMID: 38730548.
- Rooney MK, Niedzielski JS, Salazar RM, Arzola A, Das P, Koay EJ, Koong A, Ludmir EB, Minsky BD, Noticewala S, Smith GL, Taniguchi C, Holliday EB. Long-Term Patient-Reported Dyspareunia After Definitive Chemoradiation for Anal Cancer: Using the Anterior Vaginal Wall as an Organ-at-Risk to Define an Actionable Dosimetric Goal. Adv Radiat Oncol 9(5):101449, 2024. e-Pub 2024. PMID: 38550361.
- Chen X, Mumme RP, Corrigan KL, Mukai-Sasaki Y, Koutroumpakis E, Palaskas NL, Nguyen CM, Zhao Y, Huang K, Yu C, Xu T, Daniel A, Balter PA, Zhang X, Niedzielski JS, Shete SS, Deswal A, Court LE, Liao Z, Yang J. Deep learning-based automatic segmentation of cardiac substructures for lung cancers. Radiother Oncol 191:110061, 2024. e-Pub 2024. PMID: 38122850.
- Salazar RM, Duryea JD, Leone AO, Nair SS, Mumme RP, De B, Corrigan KL, Rooney MK, Das P, Holliday EB, Court LE, Niedzielski JS. Random Forest Modeling of Acute Toxicity in Anal Cancer: Effects of Peritoneal Cavity Contouring Approaches on Model Performance. Int J Radiat Oncol Biol Phys 118(2):554-564, 2024. e-Pub 2024. PMID: 37619789.
- Baroudi H, Huy Minh Nguyen CI, Maroongroge S, Smith BD, Niedzielski JS, Shaitelman SF, Melancon A, Shete S, Whitaker TJ, Mitchell MP, Yvonne Arzu I, Duryea J, Hernandez S, El Basha D, Mumme R, Netherton T, Hoffman K, Court L. Automated contouring and statistical process control for plan quality in a breast clinical trial. Phys Imaging Radiat Oncol 28:100486, 2023. e-Pub 2023. PMID: 37712064.
- Rhee DJ, Beddar S, Jaoude JA, Sawakuchi G, Martin R, Perles L, Yu C, He Y, Court LE, Ludmir EB, Koong AC, Das P, Koay EJ, Taniguichi C, Niedzielski JS. Dose Escalation for Pancreas SBRT: Potential and Limitations of using Daily Online Adaptive Radiation Therapy and an Iterative Isotoxicity Automated Planning Approach. Adv Radiat Oncol 8(4):101164, 2023. e-Pub 2023. PMID: 36798731.
- Yu C, Anakwenze CP, Zhao Y, Martin RM, Ludmir EB, Niedzielski JS, Qureshi A, Das P, Holliday EB, Raldow AC, Nguyen CM, Mumme RP, Netherton TJ, Rhee DJ, Gay SS, Yang J, Court LE, Cardenas CE. Multi-organ segmentation of abdominal structures from non-contrast and contrast enhanced CT images. Sci Reps 12:19093, 2022. e-Pub 2022. PMID: 36351987.
- Niedzielski JS, Liu Y, Ng SSW, Martin RM, Perles LA, Beddar S, Rebueno N, Koay EJ, Taniguchi C, Holliday EB, Das P, Smith GL, Minsky BD, Ludmir EB, Herman JM, Koong A, Sawakuchi GO. Dosimetric Uncertainties Resulting From Interfractional Anatomic Variations for Patients Receiving Pancreas Stereotactic Body Radiation Therapy and Cone Beam Computed Tomography Image Guidance. Int J Radiat Oncol Biol Phys 111(5):1298-1309, 2021. e-Pub 2021. PMID: 34400267.
- Abi Jaoude J, Thunshelle CP, Kouzy R, Nguyen ND, Lin D, Prakash L, Bumanlag IM, Noticewala SS, Niedzielski JS, Beddar S, Ludmir EB, Holliday EB, Das P, Minsky BD, Herman JM, Katz M, Koong AC, Koay EJ, Taniguchi CM. Stereotactic Versus Conventional Radiation Therapy for Patients With Pancreatic Cancer in the Modern Era. Adv Radiat Oncol 6(6):100763, 2021. e-Pub 2021. PMID: 34934858.
- Chen Y, Maniakas A, Tan L, Cui M, Le X, Niedzielski JS, Michel KA, Harlan CJ, Lu W, Henderson YC, Mohamed ASR, Lorenzi PL, Putluri N, Bankson JA, Sandulache VC, Lai SY. Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer. Br J Cancer 124(10):1670-1679, 2021. e-Pub 2021. PMID: 33742144.
- Xu Z, Niedzielski JS, Sun C, Walker CM, Michel KA, Einstein SA, Martinez GV, Bankson JA. Correction and optimization of symmetric echo-planar spectroscopic imaging for hyperpolarized [1-13C]-pyruvate. J Magn Reson 321:106859, 2020. e-Pub 2020. PMID: 33160268.
- Niedzielski JS, Wei X, Xu T, Gomez DR, Liao Z, Bankson JA, Lai SY, Court LE, Yang J. Development and application of an elastic net logistic regression model to investigate the impact of cardiac substructure dose on radiation-induced pericardial effusion in patients with NSCLC. Acta Oncol 59(10):1193-1200, 2020. e-Pub 2020. PMID: 32678696.
- Gronberg MP, Tailor RC, Smith SA, Kry SF, Followill DS, Stojadinovic S, Niedzielski JS, Lindsay PE, Krishnan S, Aguirre F, Fujimoto TN, Taniguchi CM, Howell RM. A Mail Audit Independent Peer Review System for Dosimetry Verification of a Small Animal Irradiator. Radiat Res 193(4):341-350, 2020. e-Pub 2020. PMID: 32068498.
- Niedzielski JS, Yang J, Mohan R, Titt U, Mirkovic D, Stingo F, Liao Z, Gomez DR, Martel MK, Briere TM, Court LE. Differences in Normal Tissue Response in the Esophagus Between Proton and Photon Radiation Therapy for Non-Small Cell Lung Cancer Using In Vivo Imaging Biomarkers. Int J Radiat Oncol Biol Phys 99(4):1013-1020, 2017. e-Pub 2017. PMID: 29063837.
- Niedzielski JS, Yang J, Mohan R, Titt U, Mirkovic D, Stingo F, Liao Z, Gomez D, Martel M, Briere T, Court LE. Investigation of Differences in Normal Tissue Response in the Esophagus due to either IMRT or Proton Therapy for the treatment of non-small-cell lung cancer. International Journal of Radiation Oncology Biology Physics 99(4):1013-1020, 2017. e-Pub 2017.
- Niedzielski JS, Yang J, Stingo F, Liao Z, Gomez D, Mohan R, Martel M, Briere T, Court L. A Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials. Sci Rep 7(1):6034, 2017. e-Pub 2017. PMID: 28729729.
- Niedzielski JS, Yang J, Liao Z, Gomez DR, Stingo F, Mohan R, Martel MK, Briere TM, Court LE. (18)F-Fluorodeoxyglucose Positron Emission Tomography Can Quantify and Predict Esophageal Injury During Radiation Therapy. Int J Radiat Oncol Biol Phys 96(3):670-8, 2016. e-Pub 2016. PMID: 27681764.
- Niedzielski JS, Yang J, Stingo F, Martel MK, Mohan R, Gomez DR, Briere TM, Liao Z, Court LE. Objectively quantifying radiation esophagitis with novel computed tomography-based metrics. Int J Radiat Oncol Biol Phys 94(2):385-393, 2016. e-Pub 2016. PMID: 26675063.
- Niedzielski J, Bluett JB, Williamson RT, Liao Z, Gomez DR, Court LE. Analysis of esophageal-sparing treatment plans for patients with high-grade esophagitis. J Appl Clin Med Phys 14(4):4248, 2013. e-Pub 2013. PMID: 23835390.
Review Articles
- Robinson DJ, Barsoumian HB, Nalin AP, Verma V, Niedzielski JS, Puebla-Osorio N, Hu Y, Kang M, Shah SJ, Phan J, Welsh JW. Real-World Guide for Delivering Immunotherapy With Radiation Therapy. Practical Radiation Oncology 16(3):222-233, 2026. e-Pub 2026. PMID: 41061930.
Abstracts
- Baroudi H, Fru LC, Schofield DL, Nguyen CM, Al Afifi S, Evans SB, Gifford KA, Netherton TJ, Niedzielski JS, Melancon AD, Mohammad I, Muruganandham M, Shaitelman S, Shaw W, Shete SS, Shulman A, Smith B, Murina P, Thengumpallil S, Venencia CD, Vrieling C, Mitchell MP, Court LE. Evaluating the Performance and Limitations of an Automated Treatment Planning Tool for Intact Breast Radiotherapy across Diverse Patient Populations. AAPM 2025, 2025. e-Pub 2025.
- Insley BA, Bocian B, Reiazi R, Jensen PJ, Martin Paulpeter RM, Niedzielski JS, Beddar S, Flint DB, Sawakuchi G, Perles LA. Monte Carlo Simulation of Dose Perturbations in HAM Applicator HDR Brachytherapy Treatments. AAPM 2025, 2025. e-Pub 2025.
- Ruzek JS, Hoang AMT, Dehghanpour M, Baker JS, Martin Paulpeter RM, Niedzielski JS, Beddar S, Sawakuchi GO, Holliday E, Perles LA. A Comparison of the Impact to Mean Doses to Organs at Risk of Small Versus Large Spot Sizes in Pelvic Proton Therapy. AAPM 2025, 2025. e-Pub 2025.
- Chung CV, Nair SS, Khan MS, Nguyen CM, Perles LA, Ludmir E, Martin Paulpeter RM, Court LE, Niedzielski JS. Feasibility of Rapidarc Dynamic for Lattice Radiation Therapy of Bulky Liver Tumors. AAPM 2025, 2025. e-Pub 2025.
- Nair S, Salazar RM, Leone AO, Xu T, Liao Z, Court LE, Niedzielski JS. Multi-Region Multiomic Features Improve Random Forest Toxicity Modeling of Radiation Pneumonitis. AAPM 2025, 2025. e-Pub 2025.
- Chen X, Zhang X, Xu T, Mohan R, Lin R, Maguire RC, Zhao Y, Koutroumpakis E, Palaskas NL, Deswal A, Ajdari A, Niedzielski JS, Shete SS, Yang J, Liao Z. Doses to cardiac substructures show superior predictive power and robustness over whole-heart for hscTnT elevation in NSCLC radiotherapy. ESTRO 2025, 2025. e-Pub 2025.
- Forbes TJ, Rooney MK, Niedzielski JS, Salazar RM, Holliday E. Radiation Doses to Small Bowel, Sigmoid and Anal Canal during Preoperative Radiation for Locally Advanced Rectal Cancer: Do They Impact Long-Term Bowel Function?. ASTRO 2024, 2024. e-Pub 2024.
- Nair SS, Salazar RM, Xu T, Leone A, Liao Z, Court LE, Niedzielski JS. Multiomic Based Bayesian Network Toxicity Modeling for Simultaneous Prediction of Multiple Toxicity Outcomes in NSCLC. ASTRO 2024, 2024. e-Pub 2024.
- Salazar R, Nair SS, Leone AO, Xu T, Liao Z, Court LE, Niedzielski JS. Independent Validation and Performance Comparison of Published Radiation Pneumonitis NTCP Models for IMRT, Immunotherapy and Proton Therapy Cohorts. ASTRO 2024, 2024. e-Pub 2024.
- Chen X, Weng J, Ding Y, Sobremonte A, Mohammedsaid M, Zhao Y, Zhang X, Niedzielski JS, Shete SS, Liao Z, Wang J, Lee P, Yang J. Feasibility of Cardiac Chamber Auto-Segmentation and Dose Optimization for MR-Guided Online Adaptive Radiotherapy of Central Lung Cancer. ASTRO 2024, 2024. e-Pub 2024.
- Chen X, Zhang X, Xu T, Chu Y, Zhao Y, Mohan R, Corrigan KL, Koutroumpakis E, Deswal A, Niedzielski JS, Shete SS, Court LE, Liao Z, Yang J. Dependence of High-Sensitivity Cardiac Troponin T (hs-cTnT) Elevation on Cardiac Substructure Doses in Lung Cancer Radiotherapy-Induced Cardiac Toxicity. AAPM 2024, 2024. e-Pub 2024.
- Chen X, Weng JK, Mohammedsaid M, Zhao Y, Zhang X, Niedzielski JS, Liao Z, Wang J, Subashi E, Percy L, Yang J, Ding Y. MRI Sequence Optimization for Cardiac Chamber Segmentation in MR-Guided Online Adaptive Radiotherapy for Lung Cancer. AAPM 2024, 2024. e-Pub 2024.
- Lin R, Zhang X, Xu T, Xu T, Maguire R, Corrigan K, Koutroumpakis E, Chang J, Lin S, Chen A, Nguyen Q, Gandhi S, Ning M, Bronk J, Chun S, Ajdari A, Niedzielski JS, Yang J, Chen X, Pan T, Meng Q, Tsao A, Mohan R, Deswal A, Liao Z. Preliminary Results of a Bayesian Adaptive Radiotherapy Trial to Reduce Cardiac Toxicity in NSCLC. ESTRO 2024, 2024. e-Pub 2024.
- Chang E, Wong FCL, Erwin WD, Das P, Holliday E, Koong AC, Ludmir EB, Smith GL, Taniguchi CM, Beddar S, Martin R, Niedzielski JS, Perles LA, Park PC, Kaseb A, Lee S, Tzeng CW, Vauthey JN, Koay EJ. Phase 1 Trial of SPECT-Guided Liver-Directed Ablative Radiotherapy for Patients with Low Functional Liver Volume. ASTRO 2023 117(2):S106, 2023. e-Pub 2023.
- McCullum L, Jacobson G, Tahon NH, Bhosale PR, Taniguchi CM, Ma J, Tamm EP, Koay EJ, Niedzielski JS. Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging (MRI) for Assessment of Treatment Response in Pancreatic Cancer. ASTRO 2023 117(2):S65, 2023. e-Pub 2023.
- Perles LA, Niedzielski JS, Sawakuchi G, Martin R, Schueler E, Taniguchi CM, Ludmir EB, Vivar OI, Das P, Koong AC, Farber LA, Koay EJ, Beddar S. Assessment of the Spatial Bio-Distribution of NBTXR3 for Locally Advanced or Borderline-Resectable Pancreatic Ductal Adenocarcinoma (LAPC or BRPC) Patients Undergoing Radiation Therapy. ASTRO 2023 117(2):e332-e333, 2023. e-Pub 2023.
- Nair SS, Salazar RM, Xu T, Peeler CR, Pollard-Larkin JM, Liao Z, Niedzielski JS. Multiomic Features Improve Random Forest Toxicity Modeling of Radiation Pneumonitis. AAPM 2023, 2023. e-Pub 2023.
- Salazar RM, Leone AO, Nair SS, Mumme R, Duryea J, De B, Corrigan K, Rooney M, Xu T, Das P, Liao Z, Holliday E, Court L, Niedzielski JS. A comparison of ten machine learning algorithms on their ability to calculate predictive normal tissue complication probabilities for non-small cell lung cancer and anal squamous cell carcinoma. AAPM 2023, 2023. e-Pub 2023.
- Baroudi H, Nguyen C, Maroongroge S, Smith BD, Niedzielski JS, Shaitelman S, Melancon A, Shete S, Whitaker TJ, Mitchell MP, Arzu I, Duryea J, Hernandez S, El Basha D, Mumme R, Netherton T, Hoffman K, Court LE. A statistical process control framework for monitoring plan consistency in a breast radiotherapy clinical trial. AAPM 2023, 2023. e-Pub 2023.
- Chen X, Mumme R, Nguyen C, Zhao Y, Huang K, Yu C, Corrigan K, Sasaki Y, Koutroumpaki E, Zhang X, Niedzielski JS, Shete S, Court LE, Liao Z, Yang J. Geometric and dosimetric evaluation of deep learning segmentation for cardiac substructure delineation: a comparative study. AAPM 2023, 2023. e-Pub 2023.
- McCullum L, Jacobson G, Tahon N, Bhosale P, Taniguchi C, Ma J, Tamm E, Koay EJ, Niedzielski JS. A Multiparametric Approach for Assessment of Treatment Response in Pancreatic Cancer Patients. AAPM 2023, 2023. e-Pub 2023.
- Leone AO, Mohamed A, Fuller CD, Peterson C, Garden AS, Lee A, Mayo LA, Reddy JP, Hoffman KE, Moreno A, Niedzielski JS, Court LE, Whitaker TJ. A Plan Scoring Methodology with a Visual Tool for Triage of Plan Quality in a Population-Based Context. AAPM 2023, 2023. e-Pub 2023.
- Xinru C, El Basha MD, Baroudi H, Zhao Y, Yu C, Huang K, Gay S, Nguyen CM, Aji D, Balter P, Zhang X, Niedzielski JS, Shete SS, Court LE, Liao Z, Yang J. Comparing Pretrained and Custom-Trained Auto-Segmentation Models Using a Commercial Deep Learning Framework for Regions-of-Interest in Head and Neck, Breast, and Prostate Cancer. AAPM 2023, 2023. e-Pub 2023.
- Abi Jaoude J, Niedzielski JS, Yu S, Taniguchi CM. Dose Escalation SBRT in Patients with Localized Pancreatic Cancer. ASTRO 2022 114(3):e188, 2022. e-Pub 2022.
- Yu C, Anakwenze C, Zhao Y, Martin RM, Niedzielski JS, Ludmir E, Yang J, Court LE, Cardenas C. Multi-Organ Auto-Segmentation of Abdominal Structures On Contrast-Enhanced CT Images with Escalating Training Data Size. AAPM 2022, 2022. e-Pub 2022.
- Alsanea F, Williamson T, Poenisch F, Martin RM, Beddar S, Sawakuchi GO, Perles LA, Ludmir EB, Koong A, Das P, Taniguchi C, Koay EJ, Niedzielski JS. Feasibility of Intensity Modulated Proton Therapy for Treating Pancreatic Cancer Using a Hypofractionated Approach. AAPM 2022 49(6):E673, 2022. e-Pub 2022.
- Baroudi H, Nguyen C, Maroongroge S, Smith B, Hoffman K, Niedzielski JS, Shaitelman S, Melancon A, Shete S, Whitaker T, Duryea J, Hernandez S, El Basha M, Mumme R, Netherton T, Court L. A Breast Auto-Contouring Model for Contour Verification in a Breast Radiotherapy Clinical Trial. AAPM 2022 49(6):E453-E454, 2022. e-Pub 2022.
- Salazar R, Duryea J, Leone A, Nair S, Mumme R, Baroudi H, Netherton T, Holliday E, Whitaker T, Hoffman K, Court LE, Niedzielski JS. Improvements On Acute Gastrointestinal Toxicity Modeling by Using Deep-Learning Auto-Segmentation. AAPM 2022 49(6):E848-E849, 2022. e-Pub 2022.
- Niedzielski JS, Beddar S, Martin RM, Perles L, Rebueno N, Holliday E, Smith G, Minsky B, Ludmir E, Das P, Koay E, Taniguchi C, Koong A, Sawakuchi G. Towards Daily Online Adaptive SBRT for Pancreatic Cancer: Dosimetric Analysis of Daily Adaptive Re-Planning Using Re-Optimization and Dose Escalation Techniques. AAPM 2021 48(6), 2021. e-Pub 2021.
- Niedzielski JS, Koong A, Sobremonte A, Castillo P, Lee B, Yang J. Dosimetric Evaluation for MR-Linac Online Adaptive Planning Approaches: A Case Study of Recurrent Adrenocortical Carcinoma. AAPM 2021 48(6), 2021. e-Pub 2021.
- Yu C, Anakwenze C, Zhao Y, Martin RM, Niedzielski JS, Ludmir E, Yang J, Court L, Cardenas C. Multi-Organ Auto-Segmentation of Abdominal Structures from Contrast-Enhanced and Non-Contrast-Enhanced CT Images. AAPM 2021 48(6), 2021. e-Pub 2021.
- Niedzielski JS, Ng S, Beddar S, Martin R, Holliday E, Smith G, Minsky B, Koong A, Taniguchi C, Das P, Koay E, Sawakuchi G. Dosimetric Impact of Interfraction Anatomical Variations on Breath-Hold SBRT for Pancreatic Cancer. AAPM 2020 47(6):E420, 2020. e-Pub 2020.
- Gronberg M, Tailor R, Smith S, Kry S, Followill D, Stojadinovic S, Niedzielski JS, et al. A Multi-Institutional End-To-End Dosimetry Mail Audit for Orthovoltage Small Animal Irradiators. AAPM 2020 47(6):E448, 2020. e-Pub 2020.
- Niedzielski JS, Wei X, Xu T, Gomez D, Liao Z, Bankson J, Lai S, Court LE, Yang J. Impact of cardiac substructure dose for modeling radiation toxicity in the heart. AAPM 2019 46(6):E277-E278, 2019. e-Pub 2019.
- Peters M, Howell R, Tailor R, Smith S, Kry S, Niedzielski JS, Followill D, Craft D, Fujimoto T, Taniguchi C, Krishnan S. Development of An Independent Peer Review System for a Small Animal Irradiator. AAPM 2018 45(6):E559, 2018. e-Pub 2018.
- Michel K, Walker C, Niedzielski JS, Chen Y, Lai S, Ravorri M, Kundra V, Merritt M, Bankson J. Design and Implementation of a Flexible Imaging Sequence for Pre-Clinical hyperpolarized 13C MRI. AAPM 2018 45(6):E155, 2018. e-Pub 2018.
- Niedzielski JS, Bankson J, Michel K, Walker C, Chen Y, Lai S. Analysis of Pharmacokinetic Modeling and Doxycycline to Quantify Tumor Metabolism Variations Using Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Imaging. AAPM 2018 45(6):E370, 2018. e-Pub 2018.
- Niedzielski JS, Titt U, Yang J, Mohan R, Mirkovic D, Stingo F, Gomez D, Liao Z, Martel M, Briere T, Court L. Analysis of Normal Tissue Response in the Esophagus Between IMRT and Proton Therapy Using Imaging Biomarkers. AAPM 2017 44(6):2748-2749, 2017. e-Pub 2017.
- Niedzielski JS, Yang J, Stingo F, Liao Z, Gomez D, Mohan R, Martel M, Briere T, Court L. A Novel CT Imaging Biomarker to Quantify Radiation Injury in the Esophagus with Application to Outcome Assessment. AAPM 2017 44(6):3256-3257, 2017. e-Pub 2017.
- Niedzielski J, Liao Z, Mohan R, Yang J, Stingo F, Gomez D, Martel M, Briere T, Court LE. FDG-PET can objectively quantify esophageal dose response and toxicity during radiation therapy. ESTRO 2016, 2016. e-Pub 2016.
- Niedzielski JS, Yang J, Stingo F, Krafft S, Martel M, Briere T, Mohan R, Court LE. A Novel Method to Objectively Quantify Normal Tissue Toxicity in the Esophagus. AAPM 2015 42(6 Part 27):3547, 2015. e-Pub 2015.
- Niedzielski JS, Yang J, Martel M, Tucker S, Briere T, Gomez D, Court L. The effect of radiation-induced esophageal swelling on dose-volume histograms. AAPM 2014 41(6 Part 23):398, 2014. e-Pub 2014.
- Niedzielski JS, Yang J, Martel M, Tucker S, Gomez D, Briere T, Court LE. Quantification of Dose‐Response for High Grade Esophagitis Patients Using a Novel Voxel‐To‐Voxel Method. AAPM 2014 41(6 Part 28):494, 2014. e-Pub 2014.
- Niedzielski JS, Yang J, Zhang L, Martel M, Briere T, Gomez D, Court L. Development and QA of a Novel Framework to Quantify Normal Tissue Toxicity Using the Jacobian Map. AAPM 2013 40(6 Part 27):454-455, 2013. e-Pub 2013.
- Williamson R, Bluett J, Niedzielski J, Liao Z, Gomez D, Court L. Assessing the Effect of Inter-Fractional Motion in Esophageal Sparing Plans. AAPM 2012 39(6Part18):3834, 2012. e-Pub 2012. PMID: 28518490.
- Niedzielski J, Bluett J, Williamson R, Liao Z, Gomez D, Court L. To Analyze the Clinical Impact of Esophageal Sparing on Treatment Plans for Patients with Grade 3 Esophagitis. AAPM 2012 39(6Part19):3838, 2012. e-Pub 2012. PMID: 28517054.
- Niedzielski JS, Kry S, Childress N. Development and Testing of a Single Exposure Film Calibration Procedure. AAPM 2011 38(6 Part 13):3525, 2011. e-Pub 2011.
- Niedzielski JS, Court LE, Cheung J, Beadle B, Dong L. Changes in Submandibular Gland Volume during Radiotherapy. AAPM 2011 38(6 Part 10):3495, 2011. e-Pub 2011.
- Niedzielski JS, Baldwin JA, Pellegrini E. Physical Properties of the Edge-On Ionization Front in the Trifid Nebula. AAS 2010 215:415.05, 2010. e-Pub 2010.
- Niedzielski JS. Polarization of the relativistic jet of PKS1136-135. AAS 2009 213:422.09, 2009. e-Pub 2009.
Book Chapters
- Court, LE, Nair, SS, Gay, SS, Niedzielski, JS. Advanced information and communication technologies including artificial intelligence for global radiation oncology. In: Humanitarian Engineering for Global Oncology. 1. IOP Publishing, 3-1 to 3-19, 2024.
Patient Reviews
CV information above last modified August 05, 2026