Juan Fueyo, M.D., F.A.A.N., F.A.A.A.S.
Department of Neuro-Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Professor, Tenure award, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Director of Neuro-Oncology Experimental Research, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Regular Member, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Research Interests
Oncolytic adenoviruses Cell cycle/apoptosis Autophagy p16/Rb/E2F-1 pathway Molecular therapy Gliomas Cancer biology
My laboratory's projects primarily focus on the development of novel gene therapy strategies for the treatment of malignant gliomas. Specifically, I have been examining the mechanisms of cell- cycle control and cell death that are abrogated in brain tumors. Though working mostly on the P16/Rb (retinoblastoma)/E2F-1 pathway, we are also studying the role of p16, Rb, and E2F-1 as tumor suppressor genes in gliomas. In addition, I am in the process of determining whether conventional chemotherapeutics for gliomas can be enhanced when combined with gene therapy. Another related project involves the determination of proficient means of gene delivery using oncolytic viruses. In this regard, we have identified a replication-competent adenovirus (Delta- 24) that cannot bind the Rb protein, has a potent anticancer effect, and low toxicity in quiescent normal cells. The Delta-24 adenoviral construct is currently the target of a provisional patent and is being further realized into a future clinical trial for patients with malignant brain tumors. The focus of my laboratory over the next two years will be on improving the anticancer effect of oncolytic adenoviruses and the translation of those pre-clinical findings to the clinic setting.
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Education & Training
Degree-Granting Education
| 1984 | University Autonomous of Barcelona, Barcelona, ESP, MD, Medicine |
Postgraduate Training
| 1994-1997 | Research Fellowship, Experimental Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 1985-1992 | Clinical Residency, Neurology, University Autonomous of Barcelona, Barcelona |
Experience & Service
Academic Appointments
Professor, Department of Neurosurgery - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2020
Associate Professor (Tenure), Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2012
Administrative Appointments/Responsibilities
Director Brain Tumor Program-Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2017
Institutional Committee Activities
Member, Brain Tumors- Moonshot Planning Committee Meeting, 2014 - 2015
Member, GSBS Curriculum Committee, 2011 - 2014
Member, Multidisciplinary Research Advisory Committee (MRAC), 2011 - 2014
Chairman, Study Section Review Committee for Basic Research, IRG Committee Meeting, 2007 - 2008
Vice Chairman, Study Section Review Committee for Basic Research, IRG Committee Meeting, 2006 - 2007
Member, Study Section Review Committee for Basic Research, IRG Committee Meeting, 2005 - 2006
Member, Executive Committee, Brain Tumor Center, 2005 - Present
Member, Executive Committee, Department of Neuro-Oncology, 2005 - Present
Co-Chairman, Laboratory Research Subcommittee, Brain Tumor Center, 2005 - 2010
Co-Chairman, Educational Committee, Brain Tumor Center, 2002 - 2005
Honors & Awards
| 2019 | Elected Fellow, American Academy of Neurology |
| 2016 | American Men and Women in Science |
| 2012 | Waun Ki Hong Award for Excellence Team Science [Delta-24 program], MD Anderson Cancer Center |
| 2009 | Nomination - Waun Ki Hong Award for Excellence Team Science [Delta-24 program], The University of Texas M. D. Anderson Cancer Center |
| 2003 | The Peter A. Steck Memorial Award, The Pediatric Brain Tumor Foundation of the United States of America |
| 1997 | Best Presentation Award, European Neurological Society (ENS) |
| 1995 | Travel Award, American Association for Cancer Research (AACR) |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Kan P, Srinivasan VM, Gumin J, Garcia R, Chen SR, Johnson JN, Collins DE, Chen MM, Ledbetter D, Huse J, Evan Luna ZA, Robledo A, Vasandani V, Rao A, Singh SK, Shpall EJ, Fueyo J, Gomez-Manzano C, Lang FF. Development of a Rabbit Human Glioblastoma Model for Testing of Endovascular Selective Intra-Arterial Infusion (ESIA) of Novel Stem Cell-Based Therapeutics. Neuro Oncol 26(1):127-136, 2024. e-Pub 2023. PMID: 37603323.
- Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H, Kumthekar PU, Chen CC, Aiken R, Groves MD, Ong SS, Ramakrishna R, Vogelbaum MA, Khagi S, Kaley T, Melear JM, Peereboom DM, Rodriguez A, Yankelevich M, Nair SG, Puduvalli VK, Aldape K, Gao A, López-Janeiro Á, de Andrea CE, Alonso MM, Boutros P, Robbins J, Mason WP, Sonabend AM, Stupp R, Fueyo J, Gomez-Manzano C, Lang FF, Zadeh G. Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nat Med 29(6):1370-1378, 2023. e-Pub 2023. PMID: 37188783.
- Jiang H, Shin DH, Yi Y, Fan X, Gumin J, He J, Gillard AG, Lang FF, Gomez-Manzano C, Fueyo J. Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity. Cancer Res Commun 3(6):1118-1131, 2023. e-Pub 2023. PMID: 37379361.
- Shin DH, Gillard A, Van Wieren A, Gomez-Manzano C, Fueyo J. Remission of Liquid Tumors and SARS-CoV-2 Infection: a Literature Review. Mol Ther Oncolytics 26:135-140, 2022. e-Pub 2022. PMID: 35702422.
- Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Alonso MM, Wainwright DA, Gomez-Manzano C, Fueyo J. Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer 10(7), 2022. PMID: 35902132.
- Gállego Pérez-Larraya J, Garcia-Moure M, Labiano S, Patiño-García A, Dobbs J, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, Puigdelloses M, Laspidea V, Astigarraga I, Lopez-Ibor B, Cruz O, Oscoz Lizarbe M, Hervas-Stubbs S, Alkorta-Aranburu G, Tamayo I, Tavira B, Hernandez-Alcoceba R, Jones C, Dharmadhikari G, Ruiz-Moreno C, Stunnenberg H, Hulleman E, van der Lugt J, Idoate MÁ, Diez-Valle R, Esparragosa Vázquez I, Villalba M, de Andrea C, Núñez-Córdoba JM, Ewald B, Robbins J, Fueyo J, Gomez-Manzano C, Lang FF, Tejada S, Alonso MM. Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma. N Engl J Med 386(26):2471-2481, 2022. PMID: 35767439.
- Laspidea V, Puigdelloses M, Labiano S, Marrodán L, Garcia-Moure M, Zalacain M, Gonzalez-Huarriz M, Martínez-Vélez N, Ausejo-Mauleon I, de la Nava D, Herrador-Cañete G, Marco-Sanz J, Guruceaga E, de Andrea CE, Villalba M, Becher O, Squatrito M, Matía V, Gállego Pérez-Larraya J, Patiño-García A, Gupta S, Gomez-Manzano C, Fueyo J, Alonso MM. Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas. JCI Insight 7(7), 2022. e-Pub 2022. PMID: 35393952.
- van Putten EHP, Kleijn A, van Beusechem VW, Noske D, Lamers CHJ, de Goede AL, Idema S, Hoefnagel D, Kloezeman JJ, Fueyo J, Lang FF, Teunissen CE, Vernhout RM, Bakker C, Gerritsen W, Curiel DT, Vulto A, Lamfers MLM, Dirven CMF. Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies. Clin Cancer Res 28(8):1572-1585, 2022. PMID: 35176144.
- Shimizu Y, Gumin J, Gao F, Hossain A, Shpall EJ, Kondo A, Parker Kerrigan BC, Yang J, Ledbetter D, Fueyo J, Gomez-Manzano C, Lang FF. Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma. J Neurosurg 136(3):1-11, 2022. e-Pub 2021. PMID: 34450587.
- Martinez-Velez N, Laspidea V, Zalacain M, Labiano S, García-Moure M, Puigdelloses M, Marrodan L, Gonzalez-Huarriz M, Herrador G, de la Nava D, Ausejo-Mauleon I, Fueyo J, Gomez-Manzano C, Patiño-García A, Alonso MM. Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory. Mol Cancer Ther 21(3):471-480, 2022. PMID: 34965961.
- Phillips LM, Li S, Gumin J, Daou M, Ledbetter D, Yang J, Singh S, Parker Kerrigan BC, Hossain A, Yuan Y, Gomez-Manzano C, Fueyo J, Lang FF. An immune-competent, replication-permissive Syrian Hamster glioma model for evaluating Delta-24-RGD oncolytic adenovirus. Neuro Oncol 23(11):1911-1921, 2021. PMID: 34059921.
- Puigdelloses M, Garcia-Moure M, Labiano S, Laspidea V, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, De la Nava D, Ausejo I, Hervás-Stubbs S, Herrador G, Chen Z, Hambardzumyan D, Patino Garcia A, Jiang H, Gomez-Manzano C, Fueyo J, Gállego Pérez-Larraya J, Alonso M. CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models. J Immunother Cancer 9(7), 2021. PMID: 34281988.
- Shin DH, Nguyen T, Ozpolat B, Lang F, Alonso M, Gomez-Manzano C, Fueyo J. Current Strategies to Circumvent the Anti-Viral Immunity to Optimize Cancer Virotherapy. J Immunother Cancer 9(4), 2021. PMID: 33795384.
- Garcia-Moure M, Gonzalez-Huarriz M, Labiano S, Guruceaga E, Bandres E, Zalacain M, Marrodan L, de Andrea C, Villalba M, Martinez-Velez N, Laspidea V, Puigdelloses M, Gallego Perez-Larraya J, Iñigo-Marco I, Stripecke R, Chan JA, Raabe EH, Kool M, Gomez-Manzano C, Fueyo J, Patiño-García A, Alonso MM. Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET. Clin Cancer Res 27(6):1807-1820, 2021. e-Pub 2020. PMID: 33376098.
- de la Rocha AMA, González-Huarriz M, Guruceaga E, Mihelson N, Tejada-Solís S, Díez-Valle R, Martínez-Vélez N, Fueyo J, Gomez-Manzano C, Alonso MM, Laterra J, López-Bertoni H. miR-425-5p, a SOX2 target, regulates the expression of FOXJ3 and RAB31 and promotes the survival of GSCs. Arch Clin Biomed Res 4(3):221-238, 2020. e-Pub 2020. PMID: 32905473.
- Jiang H, Shin DH, Nguyen TT, Fueyo J, Fan X, Henry V, Carrillo CC, Yi Y, Alonso MM, Collier TL, Yuan Y, Lang FF, Gomez-Manzano C. Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas. Clin Cancer Res 25(22):6801-6814, 2019. e-Pub 2019. PMID: 31455679.
- Rivera-Molina Y, Jiang H, Fueyo J, Nguyen T, Shin DH, Youssef G, Fan X, Gumin J, Alonso MM, Phadnis S, Lang FF, Gomez-Manzano C. GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory. Neurooncol Adv 1(1):vdz009, 2019. e-Pub 2019. PMID: 31608328.
- Martínez-Vélez N, Garcia-Moure M, Marigil M, González-Huarriz M, Puigdelloses M, Gallego Pérez-Larraya J, Zalacaín M, Marrodán L, Varela-Guruceaga M, Laspidea V, Aristu JJ, Ramos LI, Tejada-Solís S, Díez-Valle R, Jones C, Mackay A, Martínez-Climent JA, García-Barchino MJ, Raabe E, Monje M, Becher OJ, Junier MP, El-Habr EA, Chneiweiss H, Aldave G, Jiang H, Fueyo J, Patiño-García A, Gomez-Manzano C, Alonso MM. The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models. Nat Commun 10(1):2235, 2019. e-Pub 2019. PMID: 31138805.
- Martinez-Velez N, Marigil M, García-Moure M, Gonzalez-Huarriz M, Aristu JJ, Ramos-García LI, Tejada S, Díez-Valle R, Patiño-García A, Becher OJ, Gomez-Manzano C, Fueyo J, Alonso MM. Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models. Acta Neuropathol Commun 7(1):64, 2019. e-Pub 2019. PMID: 31036068.
- Varela-Guruceaga M, Tejada-Solís S, García-Moure M, Fueyo J, Gomez-Manzano C, Patiño-García A, Alonso MM. Oncolytic Viruses as Therapeutic Tools for Pediatric Brain Tumors. Cancers (Basel) 10(7), 2018. e-Pub 2018. PMID: 29987215.
- Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J. Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma. J Clin Oncol 36(14):1419-1427, 2018. e-Pub 2018. PMID: 29432077.
- Lang FM, Hossain A, Gumin J, Momin EN, Shimizu Y, Ledbetter D, Shahar T, Yamashita S, Parker Kerrigan B, Fueyo J, Sawaya R, Lang FF. Mesenchymal Stem Cells as Natural Bio-Factories for Exosomes Carrying miR-124a in the Treatment of Gliomas. Neuro Oncol 20(3):380-390, 2018. e-Pub 2017. PMID: 29016843.
- Tejada S, Díez-Valle R, Domínguez PD, Patiño-García A, González-Huarriz M, Fueyo J, Gomez-Manzano C, Idoate MA, Peterkin J, Alonso MM. DNX-2401, an Oncolytic Virus, for the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Gliomas: A Case Report. Front Oncol 8:61, 2018. e-Pub 2018. PMID: 29594041.
- Hossain MB, Shifat R, Li J, Luo X, Hess KR, Rivera-Molina Y, Puerta Martinez F, Jiang H, Lang FF, Hung MC, Fueyo J, Gomez-Manzano C. TIE2 associates with caveolae and regulates caveolin-1 to promote their nuclear translocation. Mol Cell Biol 37(21), 2017. e-Pub 2017. PMID: 28760776.
- Figueroa J, Phillips LM, Shahar T, Hossain A, Gumin J, Kim H, Bean AJ, Calin GA, Fueyo J, Walters ET, Kalluri R, Verhaak RG, Lang FF. Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587. Cancer Res 77(21):5808-5819, 2017. e-Pub 2017. PMID: 28855213.
- Tejada S, Alonso M, Patiño A, Fueyo J, Gomez-Manzano C, Diez-Valle R. Phase I Trial of DNX-2401 for Diffuse Intrinsic Pontine Glioma Newly Diagnosed in Pediatric Patients. Neurosurgery. e-Pub 2017. PMID: 29088386.
- Jiang H, Rivera-Molina Y, Gomez-Manzano C, Clise-Dwyer K, Bover L, Vence LM, Yuan Y, Lang FF, Toniatti C, Hossain MB, Fueyo J. Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination. Cancer Res 77(14):3894-3907, 2017. e-Pub 2017. PMID: 28566332.
- Dai B, Roife D, Kang Y, Gumin J, Rios Perez MV, Li X, Pratt M, Brekken RA, Fueyo J, Lang FF, Fleming JB. Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther 16(4):662-670, 2017. e-Pub 2017. PMID: 28138026.
- Xipell E, Aragón T, Martínez-Velez N, Vera B, Idoate MA, Martínez-Irujo JJ, Garzón AG, Gonzalez-Huarriz M, Acanda AM, Jones C, Lang FF, Fueyo J, Gomez-Manzano C, Alonso MM. Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51. Neuro Oncol 18(8):1109-19, 2016. e-Pub 2016. PMID: 26951384.
- Xipell E, Gonzalez-Huarriz M, Martinez de Irujo JJ, García-Garzón A, Lang FF, Jiang H, Fueyo J, Gomez-Manzano C, Alonso MM. Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma. Oncotarget 7(21):30626-41, 2016. e-Pub 2016. PMID: 27121320.
- Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, Fueyo J, Gomez-Manzano C. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv 2(4):e1501290, 2016. e-Pub 2016. PMID: 27757426.
- Cortes-Santiago N, Hossain MB, Gabrusiewicz K, Fan X, Gumin J, Marini FC, Alonso MM, Lang F, Yung WK, Fueyo J, Gomez-Manzano C. Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas. Oncotarget 7(13):16146-57, 2016. e-Pub 2016. PMID: 26910374.
- Klein SR, Jiang H, Hossain MB, Fan X, Gumin J, Dong A, Alonso MM, Gomez-Manzano C, Fueyo J. Critical role of autophagy in the processing of adenovirus capsid-incorporated cancer-specific antigens. PLoS One 11(4):e0153814, 2016. e-Pub 2016. PMID: 27093696.
- Acanda de la Rocha AM, López-Bertoni H, Guruceaga E, González-Huarriz M, Martínez-Vélez N, Xipell E, Fueyo J, Gomez-Manzano C, Alonso MM. Analysis of SOX2-Regulated Transcriptome in Glioma Stem Cells. PLoS One 11(9):e0163155, 2016. e-Pub 2016. PMID: 27669421.
- Avci NG, Fan Y, Dragomir A, Akay YM, Gomez-Manzano C, Fueyo J, Akay M. Delta-24-RGD Induces Cytotoxicity of Glioblastoma Spheroids in Three Dimensional PEG Microwells. IEEE Trans Nanobioscience 14(8):946-51, 2015. e-Pub 2015. PMID: 26661633.
- Klein SR, Piya S, Lu Z, Xia Y, Alonso MM, White EJ, Wei J, Gomez-Manzano C, Jiang H, Fueyo J. C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy. Oncogene 34(41):5295-301, 2015. e-Pub 2015. PMID: 25619840.
- Gabrusiewicz K, Hossain MB, Cortes-Santiago N, Fan X, Kaminska B, Marini FC, Fueyo J, Gomez-Manzano C. Macrophage Ablation Reduces M2-Like Populations and Jeopardizes Tumor Growth in a MAFIA-Based Glioma Model. Neoplasia 17(4):374-84, 2015. PMID: 25925380.
- Borthakur G, Duvvuri S, Ruvolo V, Tripathi DN, Piya S, Burks J, Jacamo R, Kojima K, Ruvolo P, Fueyo J, Konopleva M, Andreeff M. MDM2 inhibitor, Nutlin 3a, induces p53 dependent autophagy in acute leukemia by AMP kinase activation. PLoS One 10(10):e0139254, 2015. e-Pub 2015. PMID: 26440941.
- Martinez-Velez N, Xipell E, Jauregui P, Zalacain M, Marrodan L, Zandueta C, Vera B, Urquiza L, Sierrasesúmaga L, Julián MS, Toledo G, Fueyo J, Gomez-Manzano C, Torre W, Lecanda F, Patiño-García A, Alonso MM. The Oncolytic Adenovirus Delta24-RGD in Combination with Cisplatin Exerts a Potent Anti-Osteosarcoma Activity. J Bone Miner Resi 29(10):2287-96, 2014. e-Pub 2014. PMID: 24737304.
- Gabrusiewicz K, Liu D, Cortes-Santiago N, Hossain MB, Conrad CA, Aldape KD, Fuller GN, Marini FC, Alonso MM, Idoate MA, Gilbert MR, Fueyo J, Gomez-Manzano C. Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes. Oncotarget 5(8):2208-20, 2014. PMID: 24809734.
- Jiang H, Clise-Dwyer K, Ruisaard KE, Fan X, Tian W, Gumin J, Lamfers ML, Kleijn A, Lang FF, Yung WK, Vence LM, Gomez-Manzano C, Fueyo J. Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model. PLoS One 9(5):e97407, 2014. e-Pub 2014. PMID: 24827739.
- Martín V, Sanchez-Sanchez AM, Herrera F, Gomez-Manzano C, Fueyo J, Alvarez-Vega MA, Antolín I, Rodriguez C. Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells. Br J Cancer 108(10):2005-12, 2013. e-Pub 2013. PMID: 23632480.
- Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M, Kuratsu J, Lang FF. TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells. Cancer Res 73(7):2333-44, 2013. e-Pub 2013. PMID: 23365134.
- Jiang H, White EJ, Ríos-Vicil CI, Xu J, Gomez-Manzano C, Fueyo J. Human Adenovirus Type 5 Induces Cell Lysis through Autophagy and Autophagy-Triggered Caspase Activity. J Virol 85(10):4720-9, 2011. e-Pub 2011. PMID: 21367888.
- Piya S, White EJ, Klein SR, Jiang H, McDonnell TJ, Gomez-Manzano C, Fueyo J. The E1B19K Oncoprotein Complexes with Beclin 1 to Regulate Autophagy in Adenovirus-Infected Cells. PLoS One 6(12):e29467, 2011. e-Pub 2011. PMID: 22242123.
- Liu D, Martin V, Fueyo J, Lee OH, Xu J, Cortes-Santiago N, Alonso MM, Aldape K, Colman H, Gomez-Manzano C. Tie2/TEK Modulates the Interaction of Glioma and Brain Tumor Stem Cells with Endothelial Cells and Promotes an Invasive Phenotype. Oncotarget 1(8):700-9, 2010. PMID: 21321379.
- Jiang H, Martin V, Gomez-Manzano C, Johnson DG, Alonso M, White E, Xu J, McDonnell TJ, Shinojima N, Fueyo J. The RB-E2F1 Pathway Regulates Autophagy. Cancer Res 70(20):7882-93, 2010. e-Pub 2010. PMID: 20807803.
- Dembinski JL, Spaeth EL, Fueyo J, Gomez-Manzano C, Studeny M, Andreeff M, Marini FC. Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells. Cancer Gene Ther 17(4):289-97, 2010. e-Pub 2009. PMID: 19876078.
- Yong RL, Shinojima N, Fueyo J, Gumin J, Vecil GG, Marini FC, Bogler O, Andreeff M, Lang FF. Human Bone Marrow-Derived Mesenchymal Stem Cells for Intravascular Delivery of Oncolytic Adenovirus {Delta}24-RGD to Human Gliomas. Cancer Res 69(23):8932-40, 2009. e-Pub 2009. PMID: 19920199.
- Martin V, Xu J, Pabbisetty SK, Alonso MM, Liu D, Lee OH, Gumin J, Bhat KP, Colman H, Lang FF, Fueyo J, Gomez-Manzano C. Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters. Oncogene 28(24):2358-63, 2009. e-Pub 2009. PMID: 19421150.
- Gomez-Manzano C, Holash J, Fueyo J, Xu J, Conrad CA, Aldape KD, de Groot JF, Bekele BN, Yung WK. VEGF Trap induces antiglioma effect at different stages of disease. Neuro Oncol 10(6):940-5, 2008. e-Pub 2008. PMID: 18708344.
- Piao Y, Jiang H, Alemany R, Krasnykh V, Marini FC, Xu J, Alonso MM, Conrad CA, Aldape KD, Gomez-Manzano C, Fueyo J. Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity. Cancer Gene Ther 16(3):256-65. e-Pub 2008. PMID: 18927600.
- Li JY, Wang H, May S, Song X, Fueyo J, Fuller GN, Wang H. Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas. J Neurooncol 88(1):11-7, 2008. e-Pub 2008. PMID: 18246408.
- Alonso MM, Jiang H, Yokoyama T, Xu J, Bekele NB, Lang FF, Kondo S, Gomez-Manzano C, Fueyo J. Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Mol Ther 16(3):487-93, 2008. e-Pub 2008. PMID: 18253154.
- Lee OH, Xu J, Fueyo J, Alonso MM, Liu D, Martin V, Jiang H, Piao Y, Liu TJ, Gomez-Manzano C. Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1 alpha levels in glioma. Oncogene 27(9):1310-1314, 2008. e-Pub 2007. PMID: 17704802.
- Alonso MM, Gomez-Manzano C, Bekele BN, Yung WK, Fueyo J. Adenovirus-based strategies overcome temozolomide resistance by silencing the 06-methylguanine-DNA methyltransferase promoter. Cancer Res 67(24):11499-504, 2007. PMID: 18089777.
- Liu JL, Mao Z, LaFortune TA, Alonso MM, Gallick GE, Fueyo J, Yung WK. Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. Cancer Res 67(22):11054-63, 2007. PMID: 18006852.
- Cascallo M, Alonso MM, Rojas JJ, Perez-Gimenez A, Fueyo J, Alemany R. Systemic toxicity-efficacy profile of ICOVIR-5, a potent and selective oncolytic adenovirus based on the pRB pathway. Mol Ther 15(9):1607-15, 2007. e-Pub 2007. PMID: 17579575.
- Alonso MM, Cascallo M, Gomez-Manzano C, Jiang H, Bekele BN, Perez-Gimenez A, Lang FF, Piao Y, Alemany R, Fueyo J. ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo. Cancer Res 67(17):8255-63, 2007. PMID: 17804740.
- Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Knodo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo J. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst 99(18):1410-4, 2007. e-Pub 2007. PMID: 17848677.
- Alonso MM, Gomez-Manzano C, Jiang H, Bekele NB, Piao Y, Yung WK, Alemany R, Fueyo J. Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo. Cancer Gene Ther 14(8):756-761, 2007. e-Pub 2007. PMID: 17557108.
- Olson MV, Johnson DG, Jiang H, Xu J, Alonso MM, Aldape KD, Fuller GN, Bekele BN, Yung WK, Gomez-Manzano C, Fueyo J. Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res 67(9):4005-4009, 2007. PMID: 17483310.
- Jiang H, Olson MV, Medrano DR, Lee OH, Xu J, Piao Y, Alonso MM, Gomez-Manzano C, Hung MC, Yung WK, Fueyo J. A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation. Faseb J 20:2603-5, 2006. PMID: 17065226.
- Lee OH, Xu J, Fueyo J, Fuller GN, Aldape KD, Alonso MM, Piao Y, Liu TJ, Lang FF, Bekele BN, Gomez-Manzano C. Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix. Mol Cancer Res 4:915-26, 2006. PMID: 17189382.
- Lee OH, Fueyo J, Xu J, Yung WK, Lemoine MG, Lang FF, Bekele BN, Zhou X, Alonso MA, Aldape KD, Fuller GN, Gomez-Manzano C. Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth. Neoplasia 8(5):419-28, 2006. PMID: 16790091.
- Gomez-Manzano C, Alonso MM, Yung WK, McCormick F, Curiel DT, Lang FF, Jiang H, Bekele BN, Zhou X, Alemany R, Fueyo J. Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan. Clin Cancer Res 12(2):556-62, 2006. PMID: 16428500.
- Guo W, Zhu H, Zhang L, Davis J, Teraishi F, Roth JA, Stephens C, Fueyo J, Jiang H, Conrad C, Fang B. Combination effect of oncolytic adenovirotherapy and TRAIL gene therapy in syngeneic murine breast cancer models. Cancer Gene Ther 13(1):82-90, 2006. PMID: 16037823.
- Alonso MM, Fueyo J, Shay JW, Aldape KD, Jiang H, Lee OH, Johnson DG, Xu J, Kondo Y, Kanzawa T, Kyo S, Bekele BN, Zhou X, Nigro J, McDonald JM, Yung WK, Gomez-Manzano C. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. J Natl Cancer Inst 97(21):1589-600, 2005. PMID: 16264179.
- Jiang H, Alemany R, Gomez-Manzano C, Medrano DR, Lemoine MG, Olson MV, Alonso MM, Lee OH, Conrad CC, Yung WK, Fueyo J. Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses. Neoplasia 7(8):723-9, 2005. PMID: 16207474.
- Conrad C, Miller CR, Ji Y, Gomez-Manzano C, Bharara S, McMurray JS, Lang FF, Wong F, Sawaya R, Yung WK, Fueyo J. Delta24-hyCD adenovirus suppresses glioma growth in vivo by combining oncolysis and chemosensitization. Cancer Gene Ther 12(3):284-94, 2005. PMID: 15650766.
- Jiang H, Gomez-Manzano C, Alemany R, Medrano D, Alonso M, Bekele BN, Lin E, Conrad CC, Yung WK, Fueyo J. Comparative effect of oncolytic adenoviruses with E1A-55 kDa or E1B-55 kDa deletions in malignant gliomas. Neoplasia 7(1):48-56, 2005. PMID: 15720816.
- Stolarek R, Gomez-Manzano C, Jiang H, Suttle G, Lemoine MG, Fueyo J. Robust infectivity and replication of Delta-24 adenovirus induce cell death in human medulloblastoma. Cancer Gene Ther 11(11):713-20, 2004. PMID: 15332115.
- Gomez-Manzano C, Balague C, Alemany R, Lemoine MG, Mitlianga P, Jiang H, Khan A, Alonso M, Lang FF, Conrad CA, Liu TJ, Bekele BN, Yung WK, Fueyo J. A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene 23(10):1821-8, 2004. PMID: 15014451.
- Arap MA, Lahdenranta J, Hajitou A, Marini FC, 3rd, Wood CG, Wright KC, Fueyo J, Arap W, Pasqualini R. Model of unidirectional transluminal gene transfer. Mol Ther 9(2):305-10, 2004. PMID: 14759814.
- Fueyo J, Alemany R, Gomez-Manzano C, Fuller GN, Khan A, Conrad CA, Liu TJ, Jiang H, Lemoine MG, Suzuki K, Sawaya R, Curiel DT, Yung WK, Lang FF. Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst 95(9):652-60, 2003. PMID: 12734316.
- Gomez-Manzano C, Fueyo J, Jiang H, Glass TL, Lee HY, Hu M, Liu JL, Jasti SL, Liu TJ, Conrad CA, Yung WK. Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol 53(1):109-17, 2003. PMID: 12509854.
- Mitlianga PG, Gomez-Manzano C, Kyritsis AP, Fueyo J. Overexpression of E2F-1 leads to bax-independent cell death in human glioma cells. Int J Oncol 21(5):1015-20, 2002. PMID: 12370749.
- Lamfers ML, Grill J, Dirven CM, Van Beusechem VW, Geoerger B, Van Den Berg J, Alemany R, Fueyo J, Curiel DT, Vassal G, Pinedo HM, Vandertop WP, Gerritsen WR. Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy. Cancer Res 62(20):5736-42, 2002. PMID: 12384532.
- Adachi Y, Chandrasekar N, Kin Y, Lakka SS, Mohanam S, Yanamandra N, Mohan PM, Fuller GN, Fang B, Fueyo J, Dinh DH, Olivero WC, Tamiya T, Ohmoto T, Kyritsis AP, Rao JS. Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences. Oncogene 21(1):87-95, 2002. PMID: 11791179.
- Calbo J, Marotta M, Cascallo M, Roig JM, Gelpi JL, Fueyo J, Mazo A. Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer. Cancer Gene Ther 8(10):740-50, 2001. PMID: 11687897.
- Gomez-Manzano C, Mitlianga P, Fueyo J, Lee HY, Hu M, Spurgers KB, Glass TL, Koul D, Liu TJ, McDonnell TJ, Yung WK. Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2. Cancer Res 61(18):6693-7, 2001. PMID: 11559537.
- Gomez-Manzano C, Lemoine MG, Hu M, He J, Mitlianga P, Liu TJ, Yung AW, Fueyo J, Groves MD. Adenovirally-mediated transfer of E2F-1 potentiates chemosensitivity of human glioma cells to temozolomide and BCNU. Int J Oncol 19(2):359-65, 2001. PMID: 11445852.
- Im SA, Kim JS, Gomez-Manzano C, Fueyo J, Liu TJ, Cho MS, Seong CM, Lee SN, Hong YK, Yung WK. Inhibition of breast cancer growth in vivo by antiangiogenesis gene therapy with adenovirus-mediated antisense-VEGF. Br J Cancer 84(9):1252-7, 2001. PMID: 11336478.
- Mitlianga PG, Kyritsis AP, Gomez-Manzano C, Lemoine MG, Hu M, Liu TJ, Yung WK, Fueyo J. Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells. Int J Oncol 18(2):343-7, 2001. PMID: 11172602.
- Suzuki K, Fueyo J, Krasnykh V, Reynolds PN, Curiel DT, Alemany R. A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency. Clin Cancer Res 7(1):120-6, 2001. PMID: 11205899.
- Fueyo J, Gomez-Manzano C, Alemany R, Lee PS, McDonnell TJ, Mitlianga P, Shi YX, Levin VA, Yung WK, Kyritsis AP. A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo. Oncogene 19(1):2-12, 2000. PMID: 10644974.
- Im SA, Gomez-Manzano C, Fueyo J, Liu TJ, Ke LD, Kim JS, Lee HY, Steck PA, Kyritsis AP, Yung WK. Antiangiogenesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo. Cancer Research 59(4):895-900, 1999. PMID: 10029081.
- Fueyo J, Gomez-Manzano C, Yung WK, Liu TJ, Alemany R, McDonnell TJ, Shi X, Rao JS, Levin VA, Kyritsis AP. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nat Med 4(6):685-90, 1998. PMID: 9623977.
- Ke LD, Fueyo J, Chen X, Steck PA, Shi YX, Im SA, Yung WK. A novel approach to glioma gene therapy: down-regulation of the vascular endothelial growth factor in glioma cells using ribozymes. Int J Oncol 12(6):1391-6, 1998. PMID: 9592205.
- Fueyo J, Gomez-Manzano C, Yung WK, Liu TJ, Alemany R, Bruner JM, Chintala SK, Rao JS, Levin VA, Kyritsis AP. Suppression of human glioma growth by adenovirus-mediated Rb gene transfer. Neurology 50(5):1307-15, 1998. PMID: 9595979.
- Fueyo J, Gomez-Manzano C, Puduvalli VK, Martin-Duque P, Perez-Soler R, Levin VA, Yung WK, Kyritsis AP. Adenovirus-mediated p16 transfer to glioma cells induces G1 arrest and protects from paclitaxel and topotecan: implications for therapy. Int J Oncol 12(3):665-9, 1998. PMID: 9472109.
- Chintala SK, Fueyo J, Gomez-Manzano C, Venkaiah B, Bjerkvig R, Yung WK, Sawaya R, Kyritsis AP, Rao JS. Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene 15(17):2049-57, 1997. PMID: 9366522.
- Gomez-Manzano C, Fueyo J, Kyritsis AP, McDonnell TJ, Steck PA, Levin VA, Yung WK. Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis. J Natl Cancer Inst 89(14):1036-44, 1997. PMID: 9230885.
- Fueyo J, Gomez-Manzano C, Bruner JM, Saito Y, Zhang B, Zhang W, Levin VA, Yung WK, Kyritsis AP. Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas. Oncogene 13(8):1615-9, 1996. PMID: 8895506.
- Gomez-Manzano C, Fueyo J, Kyritsis AP, Steck PA, Roth JA, McDonnell TJ, Steck KD, Levin VA, Yung WK. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 56(4):694-9, 1996. PMID: 8630997.
- Fueyo J, Gomez-Manzano C, Yung WK, Clayman GL, Liu TJ, Bruner J, Levin VA, Kyritsis AP. Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 12(1):103-10, 1996. PMID: 8552379.
- Fueyo J, Gomez-Manzano C, Yung WK, Zhang W, Lee PS, Majumder S, Perhouse M, Levin VA, Kyritsis AP. A frequent polymorphism in exon 1 of the p16/CDKN2 gene. Mol Cell Probes 9(6):465-6, 1995. PMID: 8808318.
- EAFT Study Group. Silent brain infartaction in nonrheumatic atrial fibrillation. Neurology 46:159-165, 1995.
- Fueyo J, Ferrer I, Valldeoriola F, Graus F. The expression of a neuronal nuclear antigen (Ri) recognized by the human anti-Ri autoantibody in the developing rat nervous system. Neurosci Lett 162(1-2):141-4, 1993. PMID: 8121617.
- Escudero D, Barnadas A, Codina M, Fueyo J, Graus F. Anti-Ri-associated paraneoplastic neurologic disorder without opsoclonus in a patient with breast cancer. Neurology 43(8):1605-6, 1993. PMID: 8351021.
- Graus F, Rowe G, Fueyo J, Darnell RB, Dalmau J. The neuronal nuclear antigen recognized by the human anti-Ri autoantibody is expressed in central but not peripheral nervous system neurons. Neurosci Lett 150(2):212-4, 1993. PMID: 8469424.
- EAFT Study Group (includes Fueyo J). Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 342:1255-1262, 1993.
- The European Atrial Fibrillation Trial Study Group (includes Fueyo J). Optimal oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and recent cerebral ischemia. N Engl J Med 333:5-10, 1993.
- Pou Serradell A, Fueyo J, Gomez C, Oliveras C, Espadaler JM, Alameda F, Graus F. [Paraneoplastic encephalomyelitis and Lambert-Eaton syndrome]. Rev Neurol (Paris) 148(10):605-9, 1992. PMID: 1338234.
Invited Articles
- Vogelbaum MA, Li G, Heimberger AB, Lang FF, Fueyo J, Gomez-Manzano C, Sanai N. A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology. Am Soc Clin Oncol Educ Book 42:1-8, 2022. PMID: 35580289.
- Fueyo J, Gomez-Manzano C, Lang FF, Alonso MM. Hitchhiking to brain tumours: stem cell delivery of oncolytic viruses. Lancet Oncol 22(8):1049-1051, 2021. e-Pub 2021. PMID: 34214494.
- Ene CI, Fueyo J, Lang FF. Delta-24 adenoviral therapy for glioblastoma: Evolution from the bench to bedside and future considerations. Neurosurg Focus 50(2):E6, 2021. e-Pub 2021. PMID: 33524949.
- Klionsky DJ, Abdelmohsen K, Abe A, et al (includes Fueyo J). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222, 2016. PMID: 26799652.
- Jiang H, Gomez-Manzano C, Rivera-Molina Y, Lang FF, Conrad CA, Fueyo J. Oncolytic adenovirus research evolution: from cell-cycle checkpoints to immune checkpoints. Curr Opin Virol 13:33-39, 2015. e-Pub 2015. PMID: 25863716.
- Jiang H, Fueyo J. Healing after death: anti tumor immunity induced by oncolytic adenoviral therapy. Oncoimmunology 3(7), 2014.
- Klionsky DJ, et al. [includes Fueyo, J]. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4):445-544, 2012. PMID: 22966490.
- Fueyo J, Gomez-Manzano C, Yung WK. Advances in Translational Research in Neuro-Oncology. Arch Neurol 68(3):303-8, 2011. e-Pub 2010. PMID: 21059986.
- Jiang H, Martin V, Alonso M, Gomez-Manzano C, Fueyo J. RB-E2F1: Molecular rheostat for autophagy and apoptosis. Autophagy 6(8):1216-7, 2010. e-Pub 2010. PMID: 20935482.
- Gomez-Manzano C, Fueyo J. Oncolytic adenoviruses for the treatment of brain tumors. Curr Opin Mol Ther 12(5):530-7, 2010. PMID: 20886384.
- Jiang H, Fueyo J. Eradication of brain tumor stem cells with an oncolytic adenovirus. Discov Med 10(50):24-8, 2010. PMID: 20670595.
- Klionsky DJ, Codogno P, Cuervo AM, Deretic V, Elazar Z, Fueyo J, Gewirtz DA, Kroemer G, Levine B, Mizushima N, Rubinsztein DC, Thumm M, Tooze SA. A comprehensive glossary of autophagy-related molecules and processes. Autophagy 6(4):438-448, 2010. PMID: 20484971.
- Jiang H, Gomez-Manzano C, Lang F, Alemany R, Fueyo J. Oncolytic adenovirus: preclinical and clinical studies in patients with human malignant gliomas. Curr Gene Ther 9(5):422-7, 2009. PMID: 19860656.
- Alonso MM, Alemany R, Fueyo J, Gomez-Manzano C. E2F1 in gliomas: A paradigm of oncogene addiction. Cancer Lett 263(2):157-63, 2008. e-Pub 2008. PMID: 18334281.
- Jiang H, White EJ, Gomez-Manzano C, Fueyo J.. Adenovirus's last trick: you say lysis, we say autophagy. Autophagy 4(1):118-20, 2008. e-Pub 2007. PMID: 18032923.
- Klionsky DJ, Fueyo J.. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4(2):151-75, 2008. e-Pub 2007. PMID: 18188003.
- Martin V, Liu D, Fueyo J, Gomez-Manzano C.. Tie2: a journey from normal angiogenesis to cancer and beyond. Histol Histopathol. 23:773-80, 2008. PMID: 18366015.
- Gomez-Manzano C, Alonso M, Jiang H, Fueyo J.. Interspecies adenovirus fiber shows "evolutionary" advantage for oncolytic therapy of gliomas. Cancer Biol Ther 11(7):794-6, 2008. PMID: 18756625.
- Jiang H, Alonso MM, Gomez-Manzano C, Piao Y, Fueyo J. Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas. Expert Rev Anticancer Ther 6:1585-92, 2006. PMID: 17134363.
- Alonso MM, Fueyo J, Yung WK, Gomez-Manzano C. E2F1 and telomerase: alliance in the dark side. Cell Cycle 5(9):930-5, 2006. PMID: 16628012.
- Jiang H, McCormick F, Lang FF, Gomez-Manzano C, Fueyo J. Oncolytic adenoviruses as antiglioma agents. Expert Rev Anticancer Ther 6(5):697-708, 2006. PMID: 16759161.
- Gomez-Manzano C, Yung WK, Alemany R, Fueyo J. Genetically modified adenoviruses against gliomas: from bench to bedside. Neurology 63(3):418-26, 2004. PMID: 15304571.
- Jiang H, Conrad C, Fueyo J, Gomez-Manzano C, Liu TJ. Oncolytic adenoviruses for malignant glioma therapy. Front Biosci 8:d577-88, 2003. PMID: 12700119.
- Alemany R, Gomez-Manzano C, Fueyo J. [Oncolytic adenovirus for the treatment of cerebral tumors: past, present and future]. Neurologia 16(3):122-7, 2001. PMID: 11333782.
- Fueyo J, Gomez-Manzano C, Liu TJ, Yung WK. Delivery of cell cycle genes to block astrocytoma growth. J Neurooncol 51(3):277-87, 2001. PMID: 11407598.
- Alemany R, Gomez-Manzano C, Balague C, Yung WK, Curiel DT, Kyritsis AP, Fueyo J. Gene therapy for gliomas: molecular targets, adenoviral vectors, and oncolytic adenoviruses. Exp Cell Res 252(1):1-12, 1999. PMID: 10502394.
- Fueyo J, Gomez-Manzano C, Yung WK, Kyritsis AP. Targeting in gene therapy for gliomas. Arch Neurol 56(4):445-8, 1999. PMID: 10199333.
- Fueyo J, Gomez-Manzano C. Molecular control of the cellular cycle and apoptosis: new treatments for gliomas. Neurologia 8:43-47, 1999.
- Gomez-Manzano C, Fueyo J, Alameda F, Kyritsis AP, Yung WK. Gene therapy for gliomas: p53 and E2F-1 proteins and the target of apoptosis. Int J Mol Med 3(1):81-5, 1999. PMID: 9864390.
- Fueyo J, Gomez-Manzano C, Yung WK, Kyritsis AP. The functional role of tumor suppressor genes in gliomas: clues for future therapeutic strategies. Neurology 51(5):1250-5, 1998. PMID: 9818841.
- Fueyo J, Gomez-Manzano C. [Molecular control of the cellular cycle and apoptosis: new treatments for gliomas]. Neurologia 13(7):349-55, 1998. PMID: 9810797.
Editorials
- Youssef GC, Gomez-Manzano C, Sawaya R, Fueyo J. Antitumor immune response during glioma virotherapy. Neuro Oncol. PMID: 31348516.
- Fueyo J, Alonso MM, Parker Kerrigan BC, Gomez-Manzano C. Linking inflammation and cancer: the unexpected SYK world. Neuro Oncol 20(5):582-583, 2018. PMID: 29635349.
- Fueyo J, Hossain MB, Nguyen T, Gomez-Manzano C. Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway. Transl Cancer Res 6(Suppl 2):S317-S320, 2017. PMID: 28944168.
- Conrad CA, Fueyo J, Gomez-Manzano C. Intratumoral heterogeneity and intraclonal plasticity: from warburg to oxygen and back again. Neuro Oncol 16(8):1025-6, 2014. PMID: 25002413.
Abstracts
- Jiang H, Klein S, Piya S, Vence L, Yung WKA, Sawaya R, Heimberger A, Conrad C, Lang F, Gomez-Manzano C, Fueyo J. Oncolytic adenovirus Delta-24-RGD infection activates T-cell immune response against glioma cells. Neuro-Oncology, 4th Quadrennial Meeting of the World Federation of Neuro-Oncology held in conjunction with the 2013 Scientific Meeting and Education Day of the Society for Neuro-Oncology (November 21-24, 2013, San Francisco, CA) 15(Suppl. 3):iii63, 2013.
- Fueyo J, Lang F, Gomez-Manzano C, Yung A, Sawaya, Conrad C.. Examination of cancer testis antibodies and Th1/Th2 cytokines as prognosis markers in glioma patients treated with Delta-24-RGD oncolytic adenovirus. 15th International Congress of Immunology (Milan, Italy, August 22-27, 2013):182, 2013.
- Fueyo J, Gomez-Manzano C, Conrad C, Yung WKA, Aldape K, Sawaya R, Lang F. Significance of cancer autoantibodies in patients with malignant gliomas treated with Delta-24-RGD. Neurology (65th American Academy of Neurology Meeting, March 16-23, 2013, San Diego, CA) 80, 2013.
- Klein S, Hong Jiang, Sujan Piya, White EJ, Fan X, Lu Z, Yung WKA, Gomez-Manzano C, Fueyo J. C-Jun N-terminal kinases regulate adenovirus-induced autophagy: the implications for cancer immunotherapy using oncolytic adenoviruses. AACR Special Meeting: Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; December 2-5, 2012, Miami, FL, 2012.
- Fueyo J, Gomez-Manzano C, Conrad C, Heimberger A, Vence L, Aldape K, Yung WKA, Sawaya R, Fuller G, Lang. Phase I clinical trial in patients with recurrent gliomas: Delta-24-RGD oncolytic adenovirus induces an antiglioma immune-response. Journal of Neurology (Twenty-second meeting of the European Neurological Society, 9-12 June, 2012)(259):S46, 2012.
- Fueyo J, Conrad C, Gomez-Manzano C, Heimberger A, Vence L, Aldape K, Yung A, Sawaya R, Fuller G, Lang F.. Analyses of anti-cancer testis antigen antibodies in glioma patents treated with Delta-24 oncolytic adenovirus. Cancer Research (AACR 103rd Annual Meeting 2012, March 31-April 4, 2012, Chicago, IL) 72(8, suppl 1), 2012.
- Klein SR, Piya S, White EJ, Jiang H, Yung WKA, Gomez-Manzano C, Fueyo J. JNK1-phosphorylation of Bcl-2 is essential for adenoviral-induced autophagic cell death in glioma cells. In: Proceedings of the 102th Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL, 2011.
- Piya S, White EJ, Jiang H, Klein SR, McDonnell TJ, Yung WKA, Gomez-Manzano C, Fueyo J. The oncoprotein E1B19K is part of the Beclin-1 interactome in adenovirus-infected cells. In: Proceedings of the 102th Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL, 2011.
- Piya S, White E, Klein S, Jiang H, Lang F, Yung WKA, Gomez-Manzano C, Fueyo J. Delta-24-RGD modulates autophagy in glioma cells by activation of the Beclin1/PI3KC3 complexes. Neuro-Oncol (16th Annual Meeting of the Society for Neuro-Oncology/AANS/CNS Section on Tumors, Nov 17-20, 2011, Orange County, CA):iii70, 2011.
- Jiang H, White E, Rios-Vecil CI, Yung WKA, Gomez-Manzano C, Fueyo J. Oncolytic adenovirus Delta-24-RGD induces cell lysis through autophagy and autophagy -triggered caspase activity. Neuro-Oncol (16th Annual Meeting of the Society for Neuro-Oncology/AANS/CNS Section on Tumors, Nov 17-20, 2011, Orange County, California:iii116, 2011.
- Fueyo J, Gomez-Manzano C, Conrad C, Lang F. Successful translation of Delta-24-RGD: from Bench to the Bedside. The 6th Conference on Oncolytic Adenovirus as Cancer Therapeutics, March 16-19, 2011, Las Vegas, NV, 2011.
- Jiang H, Martin V, Gomez-Manzano C, Johnson DG, Alonso MM, White EJ, Xu J, McDonnell T, Shinojima N, Fueyo J. RB/E2F: gatekeepers of autophagy and apoptosis in glioma cells. Neuro-Oncol (15th Annual Meeting of the Society for Neuro-Oncology, Nov 18-21, 2010, Montreal, Canada):iv22, 2010.
- Alonso MM, Gomez-Manzano C, Cortes-Santiago N, Roche FP, Fueyo J. Salinomycin overcomes the chemoresistance of Brain Tumor Stem Cells. Neuro-Oncol (15th Annual Meeting of the Society for Neuro-Oncology, Nov 18-21, 2010, Montreal, Canada):iv96, 2010.
- Liu J-L, Mao Z, Xu J, Fueyo J, Yung WKA. Nuclear PTEN-induced autophagy is mediated through induction of ER stress in glioblastoma cells. Neuro-Oncol (15th Annual Meeting of the Society for Neuro-Oncology, Nov 18-21, 2010, Montreal, Canada:iv23, 2010.
- Fueyo J, Gomez-Manzano C, Yung WKA, Conrad C, Lang F. Continuous development of delta-24-rgd for the treatment of gliomas. Paper presented at: 8th International Conference on Brain Tumor Research and Therapy, 2010.
- Alonso M, Gomez-Manzano C, Vaillant B, Xu J, Liu D, Jiang H, White EJ, Colman H, Fueyo J. Salinomycin displays more potent anticancer effect against brain tumor stem cells than temozolomide. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR, 2010.
- Jiang H, Martin V, Gomez-Manzano C, Johnson DG, Alonso M, White EJ, Xu J, McDonnell TJ, Shinojima N, Fueyo J. RB/E2F1 in the crossroads of autophagy and apoptosis. In: Proceedings of the 101st Annual Meeting of the Americal Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR, 2010.
- Alonso M, Gomez-Manzano C, Vaillant B, Xu J, Liu D, Jiang H, White EJ, Colman H, Fueyo J. Salinomycin displays more potent anticancer effect against brain tumor stem cells than temozolomide. Special AACR Conference, Genetics and Biology of Brain Cancers, San Diego, CA,, 2009.
- Fueyo J. Successful developmental pathway of Delta-24-RGD. In: Proceedings of the 2009 NCI Translational Science Meeting (TSM 2); 2009 Nov 5-7; Vienna, VA, 2009.
- E White, H Jiang, C Gomez-Manzano, J Fueyo. Adenovirus-induced autophagy requires expression of stress-related kinases but no downregulation of AKT. Neuro Oncol 11(5):573, 2009.
- Alonso MM, Liu D, Pabbissety SK, Colman H, Yung WKA, Fueyo J, Gomez-Manzano C. Sox2 plays a pivotal role in the self-renewal property of brain tumor stem cells. Neuro Oncol 11(5):679, 2009.
- White EJ, Jiang H, Xu J, Gomez-Manzano C, Fueyo J. Involvement of autophagy in oncolysis: E1A is required but not sufficient. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR;, 2009.
- Alonso M, Pabbisetty S, Liu D, Xu J, Balasubramaniyan V, Colman H, Fueyo J Gomez-Manzano C. Sox2 is the engine of the self-renewal machinery in brain tumor stem cells. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR;, 2009.
- Jiang H, White E, Gumá S, Ji Y, Gomez-Manzano C, Conrad CA, Fueyo J. Enhanced oncolysis of glioma cells by Delta-24-RGD combining with 2-deoxyglucose through autophagic cell death. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR;, 2009.
Book Chapters
- Xipell E, Rivera-Molina Y, Gomez-Manzano C, Jiang H, Alonso M, Alemany R, Fueyo J. Conditionally Replicative Adenoviruses- Clinical Trials. In: Adenoviral Vectors for Gene Therapy. 2nd. Elsevier, 335-348, 2016.
- Balvers RK, Gomez-Manzano C, Jiang H, Piya S, Klein SR, Lamfers MLM, Dirven CMF, Fueyo J. Advances in Oncolytic Virotherapy for Brain Tumors. In: Gene Therapy of Cancer. 3rd. Elsevier, 137-152, 2014.
- Gomez-Manzano C, Jiang H, Alonso M, Yung WK, Fueyo J. Gene Therapy. In: Handb Clin Neurol. 3rd. Elsevier: Edinburgh, UK, 331-8, 2012.
- Alonso MM, Jiang H, Gomez-Manzano C, Fueyo J. Targeting Brain Tumor Stem Cells with Oncolytic Adenoviruses. In: Methods Mol Biol. Springer Science & Humana Press, 111-25, 2012.
- Alonso M, Fueyo J, Gomez-Manzano C. Malignant Gliomas: Role of E2F1 Transcription Factor. In: Tumors of the Central Nervous System. Volume 1. Springer, 89-97, 2011.
- Jiang H, Fueyo J. Gene Therapy of Brain Tumors. In: Gene-based Therapies for Cancer. 1st. Springer Science + Business Media and Humana Press, 17-32, 2010.
- Jiang H, White EJ, Conrad C, Gomez-Manzano C, Fueyo J. Autophagy pathways in glioblastoma. In: Methods Enzymology: Autophagy in Disease and Clinical Applications. Part C. Academic Press: United States, 273-86, 2009.
- Alonso MM, Fueyo J, Johnson DG, Gomez-Manzano C. The oncogenic role of E2F1 in brain tumors. In: Control of Cellular Physiology by E2F Transcription Factors. Research Signpost: Kerala, 257-270, 2008.
- Alonso MM, Gomez-Manzano C, Alemany R, Jiang H, McCormick F, Fueyo J. Conditionally replicative adenoviruses as antitumoral agents: Past, present and future. In: Cancer and Gene Therapy. Transworld Research Network: Kerala, India, 41-54, 2007.
- Jiang H, McCormick F, Gomez-Manzano C, Curiel DT, Lang FF, Yung WKA, Fueyo J. Replicating viruses for brain tumor treatment. In: Gene Therapy for Neurological Disorders. BC Decker Inc: New York, 293-326, 2006.
- Fueyo J, Gomez-Manzano C, McDonnell TJ. Cell Cycle and Apoptosis in Human Brain Tumors. In: Human Brain Tumors. Humana Press Inc, 2005.
- Fueyo J, Gomez-Manzano C, McDonnell TJ. Regulation of Cell-Cycle and Apoptosis in Human Brain Tumors. In: Brain Tumors. In series: Contemporary Cancer Research. Part II. Humana Press Inc: Totowa, NJ, 249-264, 2005.
- Stolarek R, Fueyo J, Gomez-Manzano C, Jiang H, Yung WKA. Gene-Based Therapy for Gliomas: Targeting the Cancer Genome. In: Genomic and Molecular Neuro-Oncology. Jones and Bartlett Publishers, Inc, 283-302, 2003.
- Gomez-Manzano C, Fueyo J, Yung WKA. Gene therapy approaches for gliomas. In: Brain Cancer. In series: American Cancer Society Atlas of Clinical Oncology. BC Decker, 219-237, 2001.
- Gomez-Manzano C, Lee O-H, Xu J, Fueyo J, Yung WKA. Neovascularization of malignant gliomas. In: Molecular Neuro-Oncology: Gliomas Methods and Protocols, In series: Methods in Molecular Medicine. Humana Press Inc, 2000.
- Gomez-Manzano C, Fueyo J, Kyritsis AP, Yung WKA. Tumor suppressor gene therapy for brain tumors. In: Gene Therapy for Neurological Disorders & Brain Tumors. Humana Press Inc: Totowa, NJ, 205-230, 1998.
Letters to the Editor
- Fueyo J, Gomez-Manzano C, Pascual J, Pou A. Paraneoplastic syndromes. Neurology 43: 236, 1993.
Grant & Contract Support
| Title: | Examination of the Delta-24 Vaccine Effect |
| Funding Source: | Dr. Marnie Rose Foundation |
| Role: | Principal Investigator |
| Title: | Oncolytic Immunotherapy for gliomas and cancer metastases in the era of checkpoint regulation |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Immunoplatform for Brain Tumor Research |
| Funding Source: | Dr. Marnie Rose Foundation |
| Role: | Principal Investigator |
| Title: | Oncolytic Immunotherapy for Diffuse Intrinsic Pontine Gliomas (DIPGs) |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator |
| Title: | Project 1: Tropism enhanced oncolytic adenovirus for brain tumor therapy |
| Funding Source: | NIH/NCI |
| Role: | Project Leader |
| Title: | Core A: Administrative Core |
| Funding Source: | NIH/NCI |
| Role: | Project Leader |
Patient Reviews
CV information above last modified October 10, 2024