Jun Zou, M.D., PhD.
Department of Laboratory Medicine, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Department Chair ad interim, Department of Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
CLIA director, Department of Laboratory Medicine, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Associate Professor, Department of Laboratory Medicine, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Medical Director, Department of Pathology, The University of Texas Medical Branch, Galveston, TX
Medical Director, Department of Laboratory Medicine, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2005 | University of Missouri at Columbia, Columbia, Missouri, US, Biochemistry, Ph.D |
| 1999 | Peking University First Hospital, Peking University School of Medicine, Beijing, CN, Anesthesiology, Ph.D |
| 1993 | Xian Jiaotong University School of Medicine [former name Xian Medical University], Xian, CN, MD |
Postgraduate Training
| 2014-2016 | Clinical Fellowship, Integrated HLA and Transfusion Medicine Fellowship, Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis, Missouri |
| 2011-2014 | Clinical Residency, Department of Pathology and Immunology, Washington University School of Medicine / Barnes-Jewish Hospital, St. Louis, Missouri |
| 2005-2010 | Postdoctoral Fellow, Hematology Division, Washington University School of Medicine, St. Louis, Missouri |
| 1995-1999 | Clinical Residency, Department of Anesthesiology, Peking University First Hospital, Beijing |
| 1993-1995 | Clinical Residency, Department of General Surgery, Peking University Shougang Hospital, Beijing |
Licenses & Certifications
| 2017 | American Board of Pathology, Blood Banking/Transfusion Medicine |
| 2016 | Texas Medical Board |
| 2016 | American Society for Histocompatibility & Immunogenetics |
| 2014 | Missouri Medical Board |
| 2014 | American Board of Clinical Pathology |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2022
Administrative Appointments/Responsibilities
Chair ad interim, Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2025 - Present
Other Professional Positions
Co-Chief Resident, Department of Pathology and Immunology; Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis, MO, 2012 - 2014
Instructor, Hematology Division, Internal Medicine Department, Washington University School of Medicine, St. Louis, MO, 2010 - 2011
Extramural Institutional Committee Activities
Member, Beaker CP Steering Committee, The University of Texas MD Anderson Cancer Center, 2022 - Present
Co-Chair, Clinical Genomics Council, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Human Subjects Research Informatics Subcommittee, The University of Texas MD Anderson Cancer Center, 2020 - Present
Member, Academic Review Committee for the Division of Education & Training, The University of Texas MD Anderson Cancer Center, 2020 - Present
Member, Advisory Committee, Molecular Genetic Technology Program, The University of Texas MD Anderson Cancer Center, 2018 - Present
Member, IOTOX Pre-Clinical Research Working Group, The University of Texas MD Anderson Cancer Center, 2018 - Present
Honors & Awards
| 2019 | Human Immunology, Best Paper of 2017 Award, American Society for Histocompatibility & Immunogenetics |
| 2015 | Paul E. Strandjord Young Investigator Award, 50th Annual Meeting of Academy of Clinical Laboratory Physician and Scientists |
| 2015 | Young Investigator with Distinction Awards, 50th Annual Meeting of Academy of Clinical Laboratory Physician and Scientists |
| 2005 | Margaret S.C. Cheng Fellowship, University of Missouri at Columbia |
| 1997 | Guang-Hua Award, Peking University School of Medicine |
Professional Memberships
Selected Presentations & Talks
National Presentations
- 2024. HLA and Donor Selection in HSCT: Beyond the Classical HLA Allele Matching. Invited. Clinical Conference of Histocompatibility & Immunogenetics, US.
- 2024. Effect of SIRPα Mismatch on the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation from an HLA Matched Related Donor. Invited. 38th Annual HLA & Transplant Workshop, US.
- 2024. HLA and Hematopoietic Stem Cell Transplantation. Invited. Division of Pathology & Laboratory Medicine Grand Rounds, US.
- 2023. HLA Molecular Mismatch in Hematopoietic Stem Cell Transplantation. Invited. 37th Annual HLA & Transplant Workshop, US.
- 2019. Molecular Disparity of HLA in Haploidentical Transplantation. Invited. Haploidentical Transplantation 2019. Orlando, FL, US.
- 2019. Impact of HLA Disparity in Mismatched Haplotype on the Clinical Outcomes in Haploidentical Transplantation. Invited. One Lambda 33rd Clinical Histocompatibility Workshop. Palm Spring, CA, US.
- 2018. Non-HLA Testing on Luminex Platform. Invited. One Lambda 32nd Clinical Histocompatibility Workshop. Palm Spring, CA, US.
- 2017. “Prozone Effect” Complicates Detection of Donor Specific Antibodies in Haploidentical Stem Cell Transplant Patients. Invited. One Lambda 31st Clinical Histocompatibility Workshop. Carlsbad, CA, US.
- 2015. The Clinical Relevance of Donor Specific Anti-Human Leukocyte Antigen Antibodies on Haploidentical Stem Cell Transplantation. Conference. American Association of Blood Banks (AABB) 2015 Annual Meeting. Anaheim, CA, US.
- 2015. The Clinical Relevance of Donor Specific Anti-Human Leukocyte Antigen Antibodies On Haploidentical Stem Cell Transplantation. Invited. American Association of Blood Banks (AABB) 2015 Annual Meeting. Anaheim, CA, US.
- 2015. Use of Digital PCR for Detection of Donor Cell-Free DNA in Lung Transplant Recipients with Graft Rejection and Infection. Conference. 50th annual Academy of Clinical Laboratory Physicians and Scientists (ACLPS) Meeting. Minneapolis, MN, US.
- 2015. Use of Digital PCR for Detection of Donor Cell-free DNA in Lung Transplant Recipients with Graft Rejection and Infection. Invited. 50th annual Academy of Clinical Laboratory Physicians and Scientists (ACLPS) meeting. Minneapolis, MN, US.
Grant & Contract Support
| Date: | 2024 - Present |
| Title: | Effect of SIRPalpha mismatch on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-matched related donor |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2022 - Present |
| Title: | Impact of HLA-DPB1 matching on clinical outcomes following unrelated donor transplantation using post-transplant cyclophosphamide as GVHD prophylaxis for patients with hematologic malignancies |
| Funding Source: | Center for International Blood and Marrow Transplant Research (CIBMTR) |
| Role: | Co-PI |
| Date: | 2022 - Present |
| Title: | Effect of SIRPa mismatch on the outcome of allogeneic hematopoietic stem cell transplantation from an HLA-matched related donor |
| Funding Source: | Center for International Blood and Marrow Transplant Research (CIBMTR) |
| Role: | Co-PI |
| Date: | 2022 - 2023 |
| Title: | SIRPα mismatch and the outcome of Allo-HSCT in patients with hematologic malignancy. Funding Source: MD Anderson Cancer Center Internal Research Grant, two years |
| Funding Source: | MD Anderson |
| Role: | PI |
| Date: | 2020 |
| Title: | Evaluation of the impact of HLA molecular mismatch on clinical outcomes in patients who underwent haploidentical hematopoietic stem cell transplantation |
| Funding Source: | Center for International Blood and Marrow Transplant Research (CIBMTR) |
| Role: | Co-PI |
| ID: | IB20-02 |
Selected Publications
Peer-Reviewed Articles
- McCurdy SR, Solomon SR, Shaffer BC, He M, Bolon Y, Blouin AG, Keyzner A, Socola FA, Ibrahim U, Zou J, Safah H, Saba N, Gadalla S, Perales M, Paczesny S, E Marsh SG, Petersdorf EW, Wang T, Lee SJ, Fuchs EJ. Post-Transplant Cyclophosphamide Improves Survival in HLA-DPB1 Mismatched Unrelated Donor Allogeneic Transplantation. Transplant Cell Ther, 2025. e-Pub 2025. PMID: 41043776.
- Saliba RM, Niemann M, Srour SA, Greenbaum U, Alzahrani KK, Carmazzi Y, Rondon G, Rezvani K, Daher M, Li D, Ma Q, Tanner MR, Cao K, Shpall EJ, Champlin RE, Spierings E, Zou J. Molecular Disparity of HY Antigen Affects Chronic Graft-Versus-Host Disease and Relapse in Female-to-Male Stem Cell Transplants. Transplant Cell Ther, 2025. e-Pub 2025. PMID: 40714365.
- Zou J, Kongtim P, Oran B, Srour SA, Greenbaum U, Carmazzi Y, Rondon G, Ciurea SO, Ma Q, Shpall EJ, Champlin RE, Cao K. Molecular disparity of HLA-DPB1 is associated with the development of subsequent solid cancer after allogeneic hematopoietic stem cell transplantation. Cancer 129(8):1205-1216, 2023. e-Pub 2023. PMID: 36738229.
- Zou J, Kongtim P, Srour SA, Greenbaum U, Schetelig J, Heidenreich F, Baldauf H, Moore B, Saengboon S, Carmazzi Y, Rondon G, Ma Q, Rezvani K, Shpall EJ, Champlin RE, Ciurea SO, Cao K. Donor Selection for KIR alloreactivity is associated with superior survival in haploidnetical transplant with PTCy. Front Immunol 13, 2022. e-Pub 2022. PMID: 36311784.
- Saliba RM, Srour SA, Greenbaum U, Ma Q, Carmazzi Y, Moller M, Wood J, Ciurea SO, Kongtim P, Rondon G, Li D, Saengboon S, Alousi AM, Rezvani K, Shpall EJ, Cao K, Champlin RE, Zou J. SIRPα Mismatch Is Associated With Relapse Protection and Chronic Graft-Versus-Host Disease After Related Hematopoietic Stem Cell Transplantation for Lymphoid Malignancies. Front Immunol 13, 2022. e-Pub 2022. PMID: 35874659.
- Zou J, Kongtim P, Oran B, Kosmoliaptsis V, Carmazzi Y, Ma J, Li L, Rondon G, Srour S, Copley HC, Partlow D, Ciurea S, Greenbaum U, Saliba RM, Ma Q, Shpall E, Champlin RE, Cao K. Refined HLA-DPB1 mismatch permissiveness with molecular algorithms predicts outcomes in allogeneic hematopoietic stem cell transplantation. Haematologica 107(4):844-856, 2022. e-Pub 2022. PMID: 34435482.
- Kim ST, Chu Y, Misoi M, Suarez-Almazor ME, Tayar JH, Lu H, Buni M, Kramer J, Rodriguez E, Hussain Z, Neelapu SS, Wang J, Shah AY, Tannir NM, Campbell MT, Gibbons DL, Cascone T, Lu C, Blumenschein GR, Altan M, Lim B, Valero V, Loghin ME, Tu J, Westin SN, Naing A, Garcia-Manero G, Abdel-Wahab N, Tawbi HA, Hwu P, Oliva ICG, Davies MA, Patel SP, Zou J, Futreal A, Diab A, Wang L, Nurieva R. Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy. Nat Commun 13(1):1970, 2022. e-Pub 2022. PMID: 35413951.
- Zou J, Wang T, He M, Bolon YT, Gadalla SM, Marsh SGE, Kuxhausen M, Gale RP, Sharma A, Assal A, Prestidge T, Aljurf M, Cerny J, Paczesny S, Spellman SR, Lee SJ, Ciurea SO. Number of HLA mismatched eplets is not associated with major outcomes in haploidentical transplantation with post-transplantation cyclophosphamide: A Center for International Blood and Marrow Transplant Research Study. Transplant Cell Ther 28(2):107.e1-107.e8, 2022. e-Pub 2022. PMID: 34774819.
- Ciurea S, Malki MM, Kongtim P, Zou J, Aung FM, Rondon G, Chen J, Taniguchi M, Otoukesh S, Nademanee A, Forman SJ, Champlin RE, Gendzekhadze K, Cao K. Treatment of allosensitized patients receiving allogeneic transplantation. Blood Adv 5(20):4031-4043, 2021. e-Pub 2021. PMID: 34474478.
- Saliba RM, Greenbaum U, Ma Q, Srour S, Ciurea S, Carmazzi Y, Li L, Oran B, Moller M, Wood J, Ciurea S, Kongtim P, Rondon G, Partlow D, Li D, Rezvani K, Shpall E, Champlin RE, Zou J. Mismatch in SIRPα, a regulatory protein in innate immunity, is associated with chronic GVHD in hematopoietic stem cell transplantation. Blood Advances 5(17):3407-3417, 2021. e-Pub 2021. PMID: 34495313.
- Zou J, Ciurea S, Kongtim P, Yi M, Carmazzi Y, Rondon G, Srour S, Partlow D, Champlin RE, Cao K. Molecular disparity in human leukocyte antigens is associated with outcomes in haploidentical stem cell transplantation. Blood Adv 4(15):3474-3485, 2020. e-Pub 2020. PMID: 32726398.
- Zou J, Duffy B, Slade M, Young AL, Steward N, Hachem R, Mohanakumar T. Rapid detection of donor cell free DNA in lung transplant recipients with rejections using donor-recipient HLA mismatch. Hum Immunol 78(4):342-349, 2017. e-Pub 2017. PMID: 28267558.
- Zou J, Romee R, Slade M, Phelan D, Keller J, Mohanakumar T, Grossman BJ. Untreated donor specific antibodies against HLA are associated with poor outcomes in peripheral blood haploidentical hematopoietic cell transplantation. Bone Marrow Transplantation 52(6):898-901, 2017. e-Pub 2017. PMID: 28218756.
- Zou J, Slade M, Romee R, Phelan D, Willey P, Mohanakumar T, Grossman BJ. Prozone Phenomenon Complicates Detection of Donor Specific Antibodies in Haploidentical Hematopoietic Cell Transplant Patients. Journal of Transplantation Research 1 (2)(2473-1730), 2016. e-Pub 2016.
- Zou J, Zhang C, Marjanovic J, Kisseleva MV, Majerus PW, Wilson MP. Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. Proc Natl Acad Sci U S A 109(24):9539-9544, 2012. e-Pub 2012. PMID: 22647598.
- Zou J, Chang SC, Marjanovic J, Majerus PW. MTMR9 Regulates MTMR6 Enzymatic Activity and Regulation of Apoptosis. Journal of Biological Chemistry 284(4):2064-2071, 2009. e-Pub 2009. PMID: 19038970.
- Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW. Type I Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Regulates Stress-Induced Apoptosis. Proc Natl Acad Sci U S A 104(43):16834-16839, 2007. e-Pub 2007. PMID: 17940011.
- Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Proc Natl Acad Sci U S A 102(52):18854-18859, 2005. e-Pub 2005. PMID: 16365287.
- Zou J, Glinsky VV, Landon LA, Matthews L, Deutscher SL. Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion. Carcinogenesis 26(2):309-318, 2005. e-Pub 2005. PMID: 15528216.
- Zou J, Dickerson MT, Owen NK, Landon LA, Deutscher SL. Biodistribution of filamentous phage peptide libraries in mice. Mol Biol Rep 31(2):121-129, 2004. e-Pub 2004. PMID: 15293788.
- Landon LA, Zou J, Deutscher SL. Effective combinatorial strategy to increase affinity of carbohydrate binding by peptides. Mol Divers 8(1):35-50, 2004. e-Pub 2004. PMID: 14964786.
- Zhang X, Yan B, Zou J. Resuscitation from Hemorrhagic Shock with Small-volume hypertonic sodium chloride solution/gelofusine in dogs. Journal of Peking University (Health Sciences) 32:64-67, 2000. e-Pub 2000.
- Zou J, Yan B, Zhang J, Zhang X. Effects of different ventilatory strategies on ventilator-induced lung injury: A study in a rabbit model of acute lung injury. Journal of Peking University. (Health Sciences) 31:432-435, 1999. e-Pub 1999.
Invited Articles
- Zou J, Grossman B, Mohanakumar T. Screening platelet pheresis donors for HLA antibodies. ASHI Quarterly 38(4):28-32, 2014. e-Pub 2014.
Review Articles
- Kongtim P, Vittayawacharin P, Zou J, Srour S, Shaffer B, Shapiro RM, Varma A, McGuirk J, Dholaria BR, McCurdy SR, DeZern AE, Bejanyan N, Bashey A, Furst S, Castagna L, Mariotti J, Ruggeri A, Bailen R, Teshima T, Huang XJ, Bonfim C, Aung F, Cao K, Carpenter PA, Hamadani M, Askar M, Fernandez-Vina M, Girnita A, Ciurea SO. ASTCT Consensus Recommendations on Testing and Treatment of Patients with Donor-specific Anti-HLA Antibodies. Transplant Cell Ther 30(12):1139-1154, 2024. e-Pub 2024. PMID: 39260570.
- Zou J, Majerus PW, Wilson DB, Schrade A, Chang SC, Wilson M. The role of myotybularin-related phosphatases in the control of autophagy and programmed cell death. Advances in Enzyme Regulation 52:282-289, 2011. e-Pub 2011. PMID: 22056831.
- Marjanovic J, Wilson MP, Zhang C, Zou J, Nicholas P, Majerus PW. The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model. Adv Enzyme Regul 51(1):101-105, 2011. e-Pub 2011. PMID: 21110994.
- Majerus PW, Zou J, Marjanovic J, Kisseleva MV, Wilson MP. The role of inositol signaling in the control of apoptosis. Adv Enzyme Regul 48(1):10-17, 2008. e-Pub 2008. PMID: 18486622.
- Landon LA, Zou J, Deutscher SL. Is phage display technology on target for developing peptide-based cancer drug?. Curr Drug Discov Technol 1(2):113-132, 2004. e-Pub 2004. PMID: 16472251.
Abstracts
- Cooklin S, Garcia C, Noor M, Zou J. Successful kidney transplantation in a HIV patient with strong positive T and B cell flow cytometry lymphocyte crossmatch: A case study. Human Immunology 80(Supplement):P024, 2019. e-Pub 2019.
- Zou J, Willis D, Moore B, Carmazzi Y, Cao K. KIR matching and KIR haplotype frequencies in hematopoietic stem cell transplant (HSCT) patients and HLA matched related donors. Human Immunology 78(Supplement 1):206 (P202), 2017. e-Pub 2017.
- Zou J, Barnes T, Lopez A, Pardillo W, Haneke R, Guerrero E, Cao K. The complement interference effect in HLA antibody detection in hematopoietic stem cell transplant patients: A validation study of EDTA treatment in labscreen PRA and single antigen assay. Human Immunology 78(Supplement 1):207 (P204), 2017. e-Pub 2017.
- Zou J, Duffy B, Steward N, Hachem R, Mohanakumar T. Detection of Donor Cell-Free DNA Using Digital PCR in Lung Transplant Recipients with Graft Rejection and Infection. Human Immunology 76(Supplement):68 (P045), 2015. e-Pub 2015.
- Zou J, Keller J, Romee R, Grossman B. The Clinical Relevance of Donor-Specific Anti-Human Leukocyte Antigen Antibodies for Haploidentical Stem Cell Transplantation. Transfusion 55(S3):13A (S17-010C), 2015. e-Pub 2015.
- Zou J, Grossman BJ. Evaluation of stem cell graft composition in AML patients who undergone HLA-matched allogeneic HSCT. AABB 54(2S):63A.
Book Chapters
- Zou J, Srivastava V. Chapter 4: Histocompatibility Testing and Transplantation. In: Laposata's Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory, 4th Edition. McGraw-Hill Education, 2025.
- Cao, K, Zou, J, Fernandez-Vina, M. Role of the Human Leukocyte Antigen System in Hematopoietic Stem Cell Transplantation. In: Manual of Stem Cell Transplantation and Cellular Therapies for Hematologic Malignancies. Elsevier Publishing, 17-25, 2023.
Letters to the Editor
- Ciurea S, Cao K, Zou J. Donor-specific anti-HLA antibodies and Recipient-specific anti-HLA antibodies? The conundrum on pregnancy in transplantation. American Journal of hematology 95: E128-E130, 2020.
- Zou J, Nolan DK, LaFiore AR, Scott MG. Estimating the effects of hemolysis on potassium and LDH laboratory results. Clin Chim Acta 421 (5 June 2013): 60-61, 2013.
Patient Reviews
CV information above last modified March 26, 2026