Karen Clise-Dwyer, Ph.D.

Peer-Reviewed Articles

1. Adema V, Ganan-Gomez I, Ma F, Rodriguez-Sevilla JJ, Chien K, Yang H, Thongon N, Kanagal-Shamanna R, Loghavi S, Montalban-Bravo G, Hammond D, Gu Y, Tan R, Tan L, Lorenzi P, Al-Atrash G, Clise-Dwyer K, Bejar R, Pellegrini M, Garcia-Manero G, Colla S. IL-1β-mediated inflammatory signaling drives ineffective erythropoiesis in early-stage myelodysplastic syndromes. bioRxiv, 2023. e-Pub 2023. PMID: 37808770.
2. Peshoff MM, Gupta P, Trivedi R, Oberai S, Chakrapani P, Dang M, Milam N, Maynard ME, Vaillant BD, Huse JT, Wang L, Clise-Dwyer K, Bhat KP. Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma. bioRxiv, 2023. e-Pub 2023. PMID: 37066184.
3. Montalban-Bravo G, Ma F, Thongon N, Yang H, Gomez IG, Rodriguez-Sevilla JJ, Adema V, Wildeman B, Lockyer P, Kim YJ, Tanaka T, Darbaniyan F, Pancholy S, Zhang G, Al-Atrash G, Dwyer K, Takahashi K, Garcia-Manero G, Kantarjian H, Colla S. Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in RAS -mutated chronic myelomonocytic leukemia. bioRxiv, 2023. e-Pub 2023. PMID: 37066354.
4. Zhou Y, Medik YB, Patel B, Zamler DB, Chen S, Chapman T, Schneider S, Park EM, Babcock RL, Chrisikos TT, Kahn LM, Dyevoich AM, Pineda JE, Wong MC, Mishra AK, Cass SH, Cogdill AP, Johnson DH, Johnson SB, Wani K, Ledesma DA, Hudgens CW, Wang J, Wadud Khan MA, Peterson CB, Joon AY, Peng W, Li HS, Arora R, Tang X, Raso MG, Zhang X, Foo WC, Tetzlaff MT, Diehl GE, Clise-Dwyer K, Whitley EM, Gubin MM, Allison JP, Hwu P, Ajami NJ, Diab A, Wargo JA, Watowich SS. Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration. J Exp Med 220(2), 2023. e-Pub 2022. PMID: 36367776.
5. Patel B, Zhou Y, Babcock RL, Ma F, Zal MA, Kumar D, Medik YB, Kahn LM, Pineda JE, Park EM, Tang X, Raso MG, Zal T, Clise-Dwyer K, Giancotti FG, Colla S, Watowich SS. STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity. bioRxiv, 2023. e-Pub 2023. PMID: 36798265.
6. Gulhati P, Schalck A, Jiang S, Shang X, Wu CJ, Hou P, Ruiz SH, Soto LS, Parra E, Ying H, Han J, Dey P, Li J, Deng P, Sei E, Maeda DY, Zebala JA, Spring DJ, Kim M, Wang H, Maitra A, Moore D, Clise-Dwyer K, Wang YA, Navin NE, DePinho RA. Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer. Nat Cancer 4(1):62-80, 2023. e-Pub 2022. PMID: 36585453.
7. Ganan-Gomez I, Clise-Dwyer K, Colla S. Isolation, culture, and immunophenotypic analysis of bone marrow HSPCs from patients with myelodysplastic syndromes. STAR Protoc 3(4):101764, 2022. e-Pub 2022. PMID: 36240061.
8. Adema V, Ma F, Kanagal-Shamanna R, Thongon N, Montalban-Bravo G, Yang H, Peslak SA, Wang F, Acha P, Sole F, Lockyer P, Cassari M, Maciejewski JP, Visconte V, Gañán-Gómez I, Song Y, Bueso-Ramos C, Pellegrini M, Tan TM, Bejar R, Carew JS, Halene S, Santini V, Al-Atrash G, Clise-Dwyer K, Garcia-Manero G, Blobel GA, Colla S. Targeting the EIF2AK1 signaling pathway rescues red blood cell production in SF3B1-mutant myelodysplastic syndromes with ringed sideroblasts. Blood Cancer Discov 3(6):554-567, 2022. e-Pub 2022. PMID: 35926182.
9. Vaca AM, Ioannou N, Sivina M, Vlachonikola E, Clise-Dwyer K, Kim E, Li D, Ma Q, Ferrajoli A, Estrov Z, Wierda WG, Patten PEM, Ramsay AG, Burger JA. Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures. Leukemia 36(5):1324-1335, 2022. e-Pub 2022. PMID: 35149845.
10. Ganan-Gomez I, Yang H, Ma F, Montalban-Bravo G, Thongon N, Marchica V, Richard-Carpentier G, Chien K, Manyam G, Wang F, Alfonso A, Chen S, Class C, Kanagal-Shamanna R, Ingram JP, Ogoti Y, Rose A, Loghavi S, Lockyer P, Cambo B, Muftuoglu M, Schneider S, Adema V, McLellan M, Garza J, Marchesini M, Giuliani N, Pellegrini M, Wang J, Walker J, Li Z, Takahashi K, Leverson JD, Bueso-Ramos C, Andreeff M, Clise-Dwyer K, Garcia-Manero G, Colla S. Author Correction: Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy. Nat Med 28(5):1097, 2022. PMID: 35484266.
11. Box A, Holmes L, DeLay M, Adams D, Bergeron A, Clise-Dwyer K, Cochran M, Guerra RDR, Meyer EM, Brundage KM. Cell Sorter Cleaning Practices and Their Impact on Instrument Sterility. J Biomol Tech 33(1), 2022. e-Pub 2022. PMID: 35837003.
12. McFarlin BK, Williams RR, Venable AS, Dwyer KC, Haviland DL. Image-Based Cytometry Reveals Three Distinct Subsets of Activated Granulocytes Based on Phagocytosis and Oxidative Burst. Cytometry A 83(8):745-51, 2013. e-Pub 2013. PMID: 23839911.
13. Foglietta M, Neelapu SS, Kwak LW, Jiang Y, Nattamai D, Lee ST, Fowler DH, Sportes C, Gress RE, Steinberg SM, Vence LM, Radvanyi L, Dwyer KC, Qazilbash MH, Bryant RN, Bishop MR. Neoantigen and Tumor Antigen-Specific Immunity Transferred From Immunized Donors is Detectable Early After Allogeneic Transplantation in Myeloma Patients. Bone Marrow Transplant 48(2):269-277, 2013. e-Pub 2012. PMID: 22773122.
14. Zhang M, Sukhumalchandra P, Enyenihi AA, St John LS, Hunsucker SA, Mittendorf EA, Sergeeva A, Ruisaard K, Al-Atrache Z, Ropp PA, Jakher H, Rodriguez-Cruz T, Lizee G, Clise-Dwyer K, Lu S, Molldrem JJ, Glish GL, Armistead PM, Alatrash G. A Novel HLA-A*0201 Restricted Peptide Derived From Cathepsin G is an Effective Immunotherapeutic Target in Acute Myeloid Leukemia. Clin Cancer Res 19(1):247-57, 2013. e-Pub 2012. PMID: 23147993.
15. Alatrash G, Mittendorf EA, Sergeeva A, Sukhumalchandra P, Qiao N, Zhang M, St John LS, Ruisaard K, Haugen CE, Al-Atrache Z, Jakher H, Philips AV, Ding X, Chen JQ, Wu Y, Patenia RS, Bernatchez C, Vence LM, Radvanyi LG, Hwu P, Clise-Dwyer K, Ma Q, Lu S, Molldrem JJ. Broad Cross-Presentation of the Hematopoietically Derived PR1 Antigen on Solid Tumors Leads to Susceptibility to PR1-Targeted Immunotherapy. J Immunol 189(11):5476-84, 2012. e-Pub 2012. PMID: 23105141.
16. Mittendorf EA, Alatrash G, Qiao N, Wu Y, Sukhumalchandra P, St John LS, Philips AV, Xiao H, Zhang M, Ruisaard K, Clise-Dwyer K, Lu S, Molldrem JJ. Breast Cancer Cell Uptake of the Inflammatory Mediator Neutriphil Elastase Triggers an Anticancer Adaptive Immune Reponse. Cancer Res 72(13):3153-62, 2012. e-Pub 2012. PMID: 22564522.
17. Alatrash G, Ono Y, Sergeeva A, Sukhumalchandra P, Zhang M, St John LS, Yang TH, Ruisaard K, Armistead PM, Mittendorf EA, He H, Qiao N, Rodriguez-Cruz T, Liang S, Clise-Dwyer K, Wieder ED, Lizee G, Lu S, Molldrem JJ. The Role of Antigen Cross-presentation From Leukemia Blasts on Immunity to the Leukemia-associated Antigen PR1. J Immunother 35(4):309-20, 2012. PMID: 22495388.
18. Sergeeva A, Alatrash G, He H, Ruisaard K, Lu S, Wygant J, McIntyre BW, Ma Q, Li D, St John L, Clise-Dwyer, K, Molldrem JJ. An Anti-PR1/HLA-A2 T Cell Receptor-Like Antibody Mediates Complement Dependent Cytotoxicitiy Against Acute Myeloid Leukemia Progenitor Cells. Blood 117(16):4262-72, 2011. e-Pub 2011. PMID: 21296998.
19. Ma Q, Wang C, Jones D, Quintanilla KE, Li D, Wang Y, Wieder ED, Clise-Dwyer, K, Alatrash G, Mj Y, Munsell MF, Lu S, Qazilbash MH, Molldrem JJ. Adoptive Transfer of PR1 cytotoxic T Lymphocytes Associated With Reduced Leukemia Burden in Mouse Acute Myeloid Leukemia Xenograft Model. Cytotherapy 12(8):1056-62, 2010. e-Pub 2010. PMID: 20735170.
20. Kanodia S, Wieder E, Lu S, Talpaz M, Alatrash G, Clise-Dwyer, K, Molldrem JJ. PR1-Specific T cells Are Associated With Unmaintained Cytogentic Remission of Chronic Myelogenous Leukemia After Interferon Withdrawal. PLoS One 5(7):e11770, 2010. e-Pub 2010. PMID: 20668669.
21. Samudio IJ, Duvvuri S, Clise-Dwyer, K, Watt JC, Mak D, Kantarjian H, Yang D, Ruvolo V, Borthakur G. Activation of p53 Signaling by MI-63 Induces Apoptosis in Acute Myeloid Leukemia Cells. Leuk Lymphoma 51(5):911-9, 2010. PMID: 20423286.
22. Ling X, Marini F, Konopleva M, Schober W, Shi Y, Burks J, Clise-Dwyer, K, Wang RY, Zhang W, Yuan X, Lu H, Caldwell L, Andreeff M. Mesenchymal Stem Cells Overexpressing IFN-ß Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenviron 3(1):83-95, 2010. e-Pub 2010. PMID: 21209776.
23. Tsukamoto H, Clise-Dwyer, K, Huston GE, Duso DK, Buck AL, Johnson LL, Haynes L, Swain SL. Age-Associated Increase in Lifespan of Naive CD4 T Cells Contributes to T-Cell Homeostasis but Facilitates Development of Functional Defects. Proc Natl Acad Sci U S A 106(43):18333-8, 2009. e-Pub 2009. PMID: 19815516.
24. Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M. CXCR4 Expression and Biologic Activity in Acute Myeloid Leukemia Are Dependent on Oxygen Partial Pressure. Blood 113(7):1504-12, 2009. e-Pub 2008. PMID: 18957686.
25. Samudio I, Fiegl M, McQueen T, Clise-Dwyer K, Andreeff M. The Warburg Effect in Leukemia-Stroma Cocultures is Mediated by Mitochondrial Uncoupling Associated With Uncoupling Protein 2 Activation. Cancer Res 68(13):5198-205, 2008. PMID: 18593920.
26. Jones SC, Clise-Dwyer K, Huston G, Dibble J, Eaton S, Haynes L, Swain SL. Impact of Post-Thymic Cellular Longevity on the Development of Age-Associated CD4+ T Cell Defects. J Immunol 180(7):4465-75, 2008. PMID: 18354168.
27. Clise-Dwyer K, Huston GE, Buck AL, Duso DK, Swain SL. Environmental and Intrinsic Factors Lead to Antigen Unresponsiveness in CD4+ Recent Thymic Emigrants From Aged Mice. J Immunol 178(3):1321-31, 2007. PMID: 17237378.
28. Amanna IJ, Clise-Dwyer K, Nashold FE, Hoag KA, Hayes CE. Cutting Edge: A/WySnJ Transitional B Cells Overexpress the Chromosome 15 Proapoptitic Blk Gene and Succomb to Premature Apoptosis. J Immunol 167(11):6069-72, 2001. PMID: 11714762.
29. Clise-Dwyer K, Amanna IJ, Duzeski JL, Nashold FE, Hayes CE. Genetic Studies of B-Lymphocyte Deficiency and Mastocytosis in Strain A/WySnJ Mice. Immunogenetics 53(9):729-35, 2001. e-Pub 2001. PMID: 11862404.
30. Harless SM, Lentz VM, Sah AP, Hsu BL, Clise-Dwyer K, Hilbert DM, Hayes CE, Cancro MP. Competition for BLyS-Mediated Signaling Through Bcmd/BR3 Regulates Peripheral B Lymphocyte Numbers. Curr Biol 11(24):1986-9, 2001. PMID: 11747827.
31. Hoag KA, Clise-Dwyer, K, Lim YH, Nashold FE, Gestwicki J, Cancro MP, Hayes CE. A Quantitative-Trait Locus Controlling Peripheral B-Cell Deficiency Maps to Mouse Chromosome 15. Immunogenetics 51(11):924-9, 2000. PMID: 11003386.

Invited Articles

1. Swain S, Clise-Dwyer K, Haynes L. Homeostasis and the Age-Associated Defect of CD4 T cells. Semin Immunol 17(5):370-7, 2005. PMID: 15964201.

Abstracts

1. Anna Sergeeva, PhD1*, Hong He, MD, PhD1*, Lisa St. John, PhD1*, Ling Yu1*, Rong Cai1*, Kathryn Ruissard2*, Karen Clise-Dwyer, PhD2*, Rolando Vedia, MS1*, Dan Li1*, Qing Ma, PhD1*, Celine Kerros, PhD3*, Mithil Chokshi, Ph.D.4*, Vanshika Jhonsa4*, Gang Bao, PhD4*, .... CD47 Blockade Enhances Phagocytic Activity of the TCR-Mimic Antibody Hu8F4 Against HLA-A2+ AML. Blood Journal 142(Supplement 1):47-49, 2023.
2. Alatrash, PhD, DO2, Anna Sergeeva, PhD3*, Hong He, MD, PhD3*, Lisa St. John4*, Priya Koppikar, PhD5, Celine Kerros, PhD6*, Karen Clise-Dwyer, PhD7*, Kathryn Ruissard8*, Abhishek Maiti, MD1, Courtney D. DiNardo, MD, MSc1, Elias Jabbour9, Srdan Verstovsek10, Naveen Pemmaraju, MD11, Nitin Jain, .... 616. Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Poster I. Blood Journal:47-49, 2023.
3. Alatrash, PhD, DO2, Anna Sergeeva, PhD3*, Hong He, MD, PhD3*, Lisa St. John4*, Priya Koppikar, PhD5, Celine Kerros, PhD6*, Karen Clise-Dwyer, PhD7*, Kathryn Ruissard8*, Abhishek Maiti, MD1, Courtney D. DiNardo, MD, MSc1, Elias Jabbour9, Srdan Verstovsek10, Naveen Pemmaraju, MD11, Nitin Jain, .... Phase I Study of the T-Cell Receptor-like Antibody, Hu8F4 in Patients with Relapsed and Refractory Myeloid Malignancies. Blood Journal 142(Supplement 1):47-49, 2023.
4. Fiegl M, Samudio IJ, Clise-Dwyer K, Burks J, Fritsche H, Mnjoyan ZH, Andreeff M. CXCR4 Expression and Biological Activity Is Dependent on Oxygen Partial Pressure in Acute Myeloid Leukemia. Blood 112(11), 2008.
5. Samudio IJ, Fiegl M, Konopleva M, Kaluarachchi K, McMurray JS, Korchin B, Clise-Dwyer K, Harmancey R, Guthrie P, Taegtmeyer H, Andreeff M. Targeting Anaplerotic Pathways That Support Fatty Acid Metabolism as a Therapeutic Strategy for Hematological Malignancies: The Achilles’ Heel of the Warburg Effect. Blood 112(11), 2008.
6. Nussenzveig R, Gaikwad A, Manshour T, Clise-Dwyer K, Zhang Y, Kantarjian H and Verstovsek S. Role of JAK2V617F during in vitro PV erythroid progenitor differentiation. Blood 110(11), 2007.
7. Patel B, Zhou Y, Babcock RL, Ma F, Medik YB, Kahn LM, Pineda JE, Park E, Clise-Dwyer K, Colla S, Watowich SS. STAT3 protects hematopoietic stem and progenitor cell function in noninflamed conditions. ASH.
8. Grefe M, Trujillo-Ocampo A, Boagni D, Clinton J, Hong H, Clise-Dwyer K, Cho H, Shpall EJ, Molldrem JJ, Im JS. Cord Derived 8F4CAR-iNKT Cells to Prevent Acute Myeloid Leukemia Relapse and Graft vs. Host Disease After Allogeneic Stem Cell Transplantation. ASH.
9. Garber HR, Bermack C, George JT, Kerros C, Beird HC, Mao X, Zhang J, Roszik J, Miller JP, Leonard P, Cao Y, Zhao L, Song X, Seth S, Lin P, Sun H, Wierda W, St John LS, Lu S, Khouri IF, Clise-Dwyer K, Im JS, Alatrash G, Futreal PA, Liang S, Tubo N, Koppikar P, Molldrem JJ. Co-evolution of Tumor and T Cell Repertoire after Allogeneic Stem Cell Transplant in Chronic Lymphocytic Leukemia. ASH.