Kenneth Hu, Ph.D.
Department of Immunology, Division of Discovery Science
About Kenneth Hu
As a graduate student, I ventured into the field of mechanobiology and addressed the need for methods to both measure and apply cell-scale mechanical forces. In my graduate work with Dr. Manish Butte at Stanford University, I adapted atomic force microscopy towards measurement of single cell-generated forces and mechanical properties, developing novel methods, materials, and pipelines for analysis.
Upon joining Dr. Matthew Krummel’s laboratory as a postdoctoral scholar, I developed a technique, termed ZipSeq, using light controlled DNA barcode hybridization to map single cell transcriptomes onto regions defined by microscopy. This work led to a Nature Methods publication and is paving the way for several collaborative studies in multiple tissue models. We have also developed new instrumentation and protocols to make the technology more widely accessible to the life sciences community in general. To make the most of spatially resolved single cell data, I also applied a non-negative matrix factorization approach to spatiotemporally resolved wound healing single-cell ribonucleic acid sequencing (scRNA-seq) data to identify gene programs linked across diverse cell types.
Now as an Assistant Professor in the Department of Immunology at MDACC, I am focusing my independent studies on applying our cutting-edge spatial transcriptomics approaches to identifying mechanisms for emergence of intratumoral spatial heterogeneity and how this affects the propagation of checkpoint blockade. The laboratory will combine my background in immunology with my passion for tool development to create a multidisciplinary approach towards answering fundamental questions about cell-cell interactions in the tumor microenvironment (TME).
Website: kenhulab.org
Present Title & Affiliation
Primary Appointment
Assistant Member, James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
My lab is broadly interested in developing and applying new tools for dissecting the spatial heterogeneity of the tumor microenvironment. We seek to integrate the wealth of data from imaging and single cell -omics to infer the cell-cell communication axes that drive the emergence of that spatial heterogeneity. Further, we seek to understand how this spatial heterogeneity affects the propagations of checkpoint blockade's effects in the tumor microenvironment. Our lab applies a wide range of approaches from bioengineering, imaging, single cell transcriptomics, preclinical mouse models of cancer, and computational analyses. We are always seeking motivated and passionate trainees with varied and diverse skills and educational backgrounds.
Education & Training
Degree-Granting Education
| 2017 | Stanford University, Stanford, California, US, Biophysics, Ph.D |
| 2012 | Massachusetts Institute of Technology, Cambridge, Massachusetts, US, Biology/Physics, BS |
Postgraduate Training
| 2017-2023 | Research Fellowship, Tumor Immunology, UCSF, San Francisco, California |
Experience & Service
Administrative Appointments/Responsibilities
Assistant Member, James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present
Other Professional Positions
Postdoctoral Fellow, University of California San Francisco (UCSF), San Francisco, CA, 2017 - 2023
Graduate Student, Stanford University Biophysics Program, Stanford, CA, 2012 - 2017
Undergraduate UROP Researcher, Massachusetts Institute of Technology (MIT), Cambridge, MA, 2011 - 2012
Undergraduate Research Opportunity Program (UROP) Researcher, Massachusetts Institute of Technology (MIT), Cambridge, MA, 2009 - 2011
SMART Program for High School Research, Baylor College of Medicine, Houston, TX, 2008
Honors & Awards
| 2023 - 2024 | Scholar, Cancer Prevention & Research Institute of Texas (CPRIT) |
| 2022 - 2024 | V Foundation Bridge Fellows Award, Parker Institute for Cancer Immunotherapy (PICI) |
| 2020 - 2024 | Postdoctoral Fellowship, American Cancer Society (ACS) |
| 2019 - 2020 | Postdoctoral Fellowship, Parker Institute for Cancer Immunotherapy (PICI) |
| 2017 | T32 (T32CA177555) Awardee |
| 2010 | Scholar, AMGEN |
Selected Presentations & Talks
National Presentations
- 2025. Using gene program analysis to dissect stromal-immune interactions conserved across tissue contexts. Invited. 5th GCC Immunology Symposium. Houston, Texas, US.
- 2024. Fibroblast-immune cell interactions conserved between the healing wound and tumors: their identification and implications for immunotherapy. Poster. SITC 39th Annual Meeting. Houston, Texas, US.
- 2024. Imaging anti-tumor activity to study the propagation of ICB’s effects in the TME. Invited. PICI Spring Retreat. Healdsburg, California, US.
- 2023. Aspen Cancer Conference. Conference. Aspen Cancer Conference, US.
- 2022. Identifying spatial organization at the intersection of the tumor and wound healing. Conference. JAX 31st Annual Short Course on Experimental Models of Human Cancer, US.
- 2021. On-demand Spatial Barcoding for Mapping of Single Cell Transcriptomes. Conference. Illumina Single Cell Sequencing Symposium, US.
- 2021. On-demand Spatial Barcoding for Mapping of Single Cell Transcriptomes. Conference. Conceptual Power of Single Cell Biology Symposium, US.
International Presentations
- 2019. Merging single cell transcriptomics with microscopy to link cellular heterogeneity with position. Conference. World Immune Regulation Meeting (WIRM), US.
Grant & Contract Support
| Date: | 2027 - 2028 |
| Title: | Leica Stellaris Tau-STED Multimodal Microscope |
| Funding Source: | NIH |
| Role: | Other User |
| Date: | 2026 - 2029 |
| Title: | Developing Effective Cancer Vaccine-Based Combinatorial Therapies |
| Funding Source: | Cancer Prevention and Research Institute of Texas |
| Role: | Co-I |
| ID: | RP270606 |
| Date: | 2026 - 2029 |
| Title: | The Urgent Need for Studying Air Pollution-Induced Lung Injury and Adenocarcinoma |
| Funding Source: | Cancer Prevention and Research Institute of Texas |
| Role: | Co-PI |
| ID: | RP 270021 |
| Date: | 2026 - 2031 |
| Title: | F.I.R.E.F.L.Y. – FLASH-Integrated Radiation & Immuno-Engineering for Low Cost, High Yield Therapy |
| Funding Source: | Advanced Research Projects Agency for Health |
| Role: | Co-I |
| ID: | FP00030384 |
| Date: | 2026 - 2027 |
| Title: | Dissecting B-T Cell Interactions/Aggregation and Their Role in Control of Invasive PDAC |
| Funding Source: | Hirshberg Foundation |
| Role: | PI |
| ID: | FP00030465 |
| Date: | 2026 - 2028 |
| Title: | A Universal Tool for Unravelling the Requirements for Clinically Relevant Cell-Cell Interactions via In Situ Phenotyping and Tagging of Live Cells |
| Funding Source: | Narwhal Bio |
| Role: | PI |
| ID: | FP00025996_Res1 |
| Date: | 2026 - 2030 |
| Title: | Spatiotemporal Mapping of Tumor Cell Death Rates During Immune Checkpoint Blockade to Identify Rate-limiting Steps in Response |
| Funding Source: | American Cancer Society (ACS) |
| Role: | PI |
| ID: | FP00026859 |
| Date: | 2025 - 2028 |
| Title: | Spatiotemporal Mapping of Tumor Cell Death Rates During Immune Checkpoint Blockade to Identify Rate-limiting Steps in Response |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP260447 |
| Date: | 2025 - 2028 |
| Title: | Developing a first-in-class, non-cytotoxic antibody-toxin conjugate for cancer immunotherapy |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | FP00025785 |
| Date: | 2025 - 2030 |
| Title: | Dissecting mechanisms by which mRNA vaccines encoding nontumor antigens initiate antitumor immunity |
| Funding Source: | NIH |
| Role: | Other Significant Contributor |
| ID: | FP00025378 |
| Date: | 2025 - 2030 |
| Title: | Developing Effective Cancer Vaccine-Based Combinatorial Therapies |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01CA291917-01A1 |
| Date: | 2025 - 2030 |
| Title: | Targeting Macrophage and T Cell Networks to Enhance Cancer Immunotherapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1 R01 CA 314062 - 01 |
| Date: | 2025 - 2028 |
| Title: | Developing Effective Cancer Vaccine-Based Combinatorial Therapies |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP260524 |
| Date: | 2025 - 2027 |
| Title: | A Universal Tool for Unravelling the Requirements for Clinically Relevant Cell-Cell Interactions via In Situ Phenotyping and Tagging of Live Cells |
| Funding Source: | Narwhal Bio |
| Role: | PI |
| ID: | FP00025996 |
| Date: | 2025 - 2027 |
| Title: | Remodeling Myeloid Immunosuppression and Defining Spatial Biomarkers to Improve Neoantigen Cancer Vaccine Efficacy |
| Funding Source: | American Cancer Society - Yosemite |
| Role: | Co-I |
| ID: | FP00026852 |
| Date: | 2025 - 2026 |
| Title: | Untangling the Fibroblast Wiring Diagram for Enhanced Immune Infiltration in Pancreatic Cancer |
| Funding Source: | Hirshberg Foundation |
| Role: | PI |
| ID: | FP00027526 |
| Date: | 2025 - 2030 |
| Title: | A Novel Genetic Toolbox for Tracking and Mechanistically Dissecting Immune Cell Egress from Tumors for Next Generation Combination Therapies |
| Funding Source: | NIH |
| Role: | PI |
| ID: | 1DP2OD038538-01 |
| Date: | 2025 - 2030 |
| Title: | Microbial-inspired Immune-stimulating Antibody-toxin Conjugate (ATC) for Cancer Immunotherapy |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | 1R01CA305986-01 |
| Date: | 2025 - 2027 |
| Title: | Predator and Prey: Imaging Tumor Death, Growth, and Dormancy Following Immunotherapy |
| Funding Source: | Melanoma Research Foundation (MRF) |
| Role: | PI |
| ID: | FP00025914 |
| Date: | 2025 - 2029 |
| Title: | Preclinical evaluation of a first-in-class, non-cytotoxic, antibody-toxin conjugate for cancer immunotherapy |
| Funding Source: | V Foundation |
| Role: | Co-I |
| ID: | FP00025976 |
| Date: | 2025 - 2028 |
| Title: | Helping Immunotherapy Make the Cut: Spatial and Highly Multiplexed Readouts for Intratumoral Protease Activity |
| Funding Source: | Searle Scholars Program |
| Role: | PI |
| ID: | FP00024376 |
| Date: | 2024 - 2026 |
| Title: | Gravity-based Microfluidics for Enabling High-throughput Functional Genomics Screens for Molecular Mediators of Cell-cell Interactions |
| Funding Source: | John S Dunn Research Foundation |
| Role: | PI |
| ID: | FP00023106 |
| Date: | 2024 - 2028 |
| Title: | Quantifying, perturbing and mechanistically dissecting immune cell egress from tumors for next generation combination therapies |
| Funding Source: | American Cancer Society (ACS) |
| Role: | PI |
| ID: | FP00021051 |
| Date: | 2024 - 2029 |
| Title: | Bhlhe40 Regulation of T Cell Function During Cancer Immunotherapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | CA282027-01A1 |
| Date: | 2024 - 2025 |
| Title: | UT System Rising STARs Award |
| Funding Source: | The University of Texas System |
| Role: | PI |
| ID: | Fund: 129252 |
| Date: | 2024 - 2026 |
| Title: | A Universal Tool for Unravelling the Requirements for Clinically Relevant Cell-Cell Interactions via In Situ Phenotyping and Tagging of Live Cells |
| Funding Source: | Narwhal Bio |
| Role: | PI |
| ID: | FP00020540_Res1 |
| Date: | 2024 - 2026 |
| Title: | A genetic toolbox for tracking immune cell egress from tumor to inform future immunotherapies |
| Funding Source: | Institutional Research Grant (IRG) |
| Role: | PI |
| ID: | RCTS 00063425 |
| Date: | 2023 - 2025 |
| Title: | Identification of Mechanisms by Which the Non-Immune Stroma Controls Immune Cell Infiltration and Expression States in the Tumor |
| Funding Source: | Parker Institute for Cancer Immunotherapy + V Foundation |
| Role: | PI |
| ID: | D2022-004B |
| Date: | 2023 - 2030 |
| Title: | James P. Allison Institute Assistant Member Research Support Package |
| Funding Source: | James P. Allison Institute |
| Role: | PI |
| ID: | Fund: 128332 |
| Date: | 2023 - 2028 |
| Title: | Dissecting and Exploiting the Emergent Spatial Heterogeneity of Solid Tumors |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RR230012 |
| Date: | 2022 - 2027 |
| Title: | Start-Up Funds |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| ID: | Fund: 128276 |
Selected Publications
Peer-Reviewed Articles
- Kuhn, NF, Zaleta-Linares, I, Hu, KH, Courau, T, Davidson, B, Tam, T, Chu, CW, Kinet, MJ, Rosenblum, MD, Combes, AJ, Nyberg, WA, Eyquem, J, Krummel, MF. Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state. The Journal of experimental medicine 223(5), 2026. e-Pub 2026. PMID: 41879666.
- Ray, A, Bassette, M, Hu, KH, Pass, LF, Courau, T, Samad, B, Combes, AJ, Johri, V, Davidson, B, Wai, K, Ha, P, Hernandez, G, Zaleta-Linares, I, Krummel, MF. Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors. Science Immunology 10(109), 2025. e-Pub 2025. PMID: 40644511.
- Tanaka, M, Lum, L, Hu, KH, Chaudhary, P, Hughes, S, Ledezma-Soto, C, Samad, B, Superville, D, Ng, K, Chumber, A, Benson, C, Adams, ZN, Kersten, K, Aguilar, OA, Fong, L, Combes, AJ, Krummel, MF, Reeves, MQ. Tumor cell heterogeneity drives spatial organization of the intratumoral immune response. The Journal of experimental medicine 222(6), 2025. e-Pub 2025. PMID: 40167599.
- McIntyre, TI, Valdez, O, Kochhar, NP, Davidson, B, Samad, B, Qiu, L, Hu, KH, Combes, AJ, Erlebacher, A. KDM6B-dependent epigenetic programming of uterine fibroblasts in early pregnancy regulates parturition timing in mice. Cell 188(5):1265-1279.e18, 2025. e-Pub 2025. PMID: 39842437.
- Keshari, S, Shavkunov, A, Miao, Q, Saha, A, Minowa, T, Molgora, M, Williams, CD, Chaib, M, Highsmith, AM, Pineda, JE, Alekseev, S, Alspach, E, Hu, KH, Colonna, M, Pauken, KE, Chen, K, Gubin, M. Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy. Cell Reports 43(11), 2024. e-Pub 2024. PMID: 39446585.
- Keshari S, Shavkunov AS, Miao Q, Saha A, Williams CD, Highsmith AM, Pineda JE, Alspach E, Hu KH, Pauken KE, Chen K, Gubin MM. Neoantigen Cancer Vaccines and Different Immune Checkpoint Therapies Each Utilize Both Converging and Distinct Mechanisms that in Combination Enable Synergistic Therapeutic Efficacy. bioRxiv, 2024. e-Pub 2024. PMID: 38187708.
- Ray A, Hu KH, Kersten K, Kuhn NF, Samad B, Combes AJ, Krummel MF. Critical role of CD206+ macrophages in organizing anti-tumor immunity. bioRxiv, 2023. e-Pub 2023. PMID: 37961697.
- Hackney, J, Shivram, H, Vander Heiden, JA, Overall, C, Orozco, L, Gao, X, Kim, E, West, N, Qamra, A, Chang, D, Chakrabarti, A, Choy, DF, Combes, AJ, Courau, T, Fragiadakis, GK, Rao, AA, Ray, A, Tsui, J, Hu, KH, Kuhn, NF, Krummel, MF, Erle, DJ, Kangelaris, K, Sarma, A, Lyon, Z, Calfee, C, Woodruff, PG, Ghale, R, Mick, E, Byrne, A, Zha, BS, Langelier, C, Hendrickson, CM, van der Wijst, MG, Hartoularos, GC, Grant, T, Bueno, R, Lee, D, Greenland, JR, Sun, Y, Perez, R, Ogorodnikov, A, Ward, A, Ye, CJ, Abe-Jones, Y, Adkisson, M, Ansel, KM, Asthana, S, Beagle, A, Bhide, S. A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. iScience 26(10), 2023. e-Pub 2023. PMID: 37810211.
- Ray A, Bassette M, Hu KH, Pass LF, Samad B, Combes A, Johri V, Davidson B, Hernandez G, Zaleta-Linares I, Krummel MF. Multimodal identification of rare potent effector CD8 T cells in solid tumors. bioRxiv, 2023. e-Pub 2023. PMID: 37808790.
- Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger SJ, Goldrath AW. Metabolic programs of T cell tissue residency empower tumour immunity. Nature 621(7977):179-187, 2023. e-Pub 2023. PMID: 37648857.
- Hu KH, Kuhn NF, Courau T, Tsui J, Samad B, Ha P, Kratz JR, Combes AJ, Krummel MF. Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer. Cell Stem Cell 30(6):885-903.e10, 2023. e-Pub 2023. PMID: 37267918.
- Kersten K, Hu KH, Combes AJ, Samad B, Harwin T, Ray A, Rao AA, Cai E, Marchuk K, Artichoker J, Courau T, Shi Q, Belk J, Satpathy AT, Krummel MF. Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer. Cancer Cell 40(6):624-638.e9, 2022. e-Pub 2022. PMID: 35623342.
- Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, Consortium UC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq, 2022. e-Pub 2022. PMID: 35611333.
- Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, Consortium UC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv, 2022. e-Pub 2022. PMID: 35592107.
- Sarma, A, Christenson, SA, Byrne, A, Mick, E, Pisco, AO, DeVoe, C, Deiss, T, Ghale, R, Zha, BS, Tsitsiklis, A, Jauregui, A, Moazed, F, Detweiler, AM, Spottiswoode, N, Sinha, P, Neff, N, Tan, M, Serpa, PH, Willmore, A, Ansel, KM, Wilson, JG, Leligdowicz, A, Siegel, ER, Sirota, M, DeRisi, J, Matthay, MA, Abe-Jones, Y, Asthana, S, Beagle, A, Bhakta, T, Bhide, S, Cai, C, Caldera, S, Calfee, C, Calvo, M, Carrillo, S, Cattamanchi, A, Chak, S, Chan, V, Chew, N, Christenson, S, Collins, Z, Combes, AJ, Courau, T, Darmanis, S, Erle, DJ, Esmaili, A, Fragiadakis, GK, Ghale, R, Hu, KH. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nature communications 12(1), 2021. e-Pub 2021. PMID: 34446707.
- Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Consortium UC, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Nature 596(7872):E8, 2021. e-Pub 2021. PMID: 34341540.
- Pinkard H, Baghdassarian H, Mujal A, Roberts E, Hu KH, Friedman DH, Malenica I, Shagam T, Fries A, Corbin K, Krummel MF, Waller L. Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging. Nat Commun 12(1):1916, 2021. e-Pub 2021. PMID: 33772022.
- Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Consortium UC, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global absence and targeting of protective immune states in severe COVID-19. Nature 591(7848):124-130, 2021. e-Pub 2021. PMID: 33494096.
- Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global Absence and Targeting of Protective Immune States in Severe COVID-19. bioRxiv, 2020. e-Pub 2020. PMID: 33140050.
- Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Consortium UC, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global Absence and Targeting of Protective Immune States in Severe COVID-19. Res Sq, 2020. e-Pub 2020. PMID: 33140041.
- Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF. ZipSeq: barcoding for real-time mapping of single cell transcriptomes. Nat Methods 17(8):833-843, 2020. e-Pub 2020. PMID: 32632238.
- Hu KH, Krummel MF. Carpet-bombing tumors with IFN-γ. Nat Cancer 1(3):270-272, 2020. e-Pub 2020. PMID: 35122031.
- Nguyen AV, Trompetto B, Tan XHM, Scott MB, Hu KH, Deeds E, Butte MJ, Chiou PY, Rowat AC. Differential Contributions of Actin and Myosin to the Physical Phenotypes and Invasion of Pancreatic Cancer Cells. Cell Mol Bioeng 13(1):27-44, 2020. e-Pub 2020. PMID: 32030106.
- Hu KH, Bruce MA, Liu J, Butte MJ. Biochemical Stimulation of Immune Cells and Measurement of Mechanical Responses Using Atomic Force Microscopy. Curr Protoc Chem Biol 11(2):e63, 2019. e-Pub 2019. PMID: 30707509.
- Nagy N, de la Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem 293(2):567-578, 2018. e-Pub 2018. PMID: 29183997.
- Nyberg KD, Hu KH, Kleinman SH, Khismatullin DB, Butte MJ, Rowat AC. Quantitative Deformability Cytometry: Rapid, Calibrated Measurements of Cell Mechanical Properties. Biophys J 113(7):1574-1584, 2017. e-Pub 2017. PMID: 28978449.
- Thauland TJ, Hu KH, Bruce MA, Butte MJ. Cytoskeletal adaptivity regulates T cell receptor signaling. Sci Signal 10(469), 2017. e-Pub 2017. PMID: 28270556.
- Mascharak S, Benitez PL, Proctor AC, Madl CM, Hu KH, Dewi RE, Butte MJ, Heilshorn SC. YAP-dependent mechanotransduction is required for proliferation and migration on native-like substrate topography. Biomaterials 115:155-166, 2017. e-Pub 2017. PMID: 27889666.
- Hu KH, Butte MJ. T cell activation requires force generation. J Cell Biol 213(5):535-42, 2016. e-Pub 2016. PMID: 27241914.
- Nam S, Hu KH, Butte MJ, Chaudhuri O. Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels. Proc Natl Acad Sci U S A 113(20):5492-7, 2016. e-Pub 2016. PMID: 27140623.
- Gibson JL, Lombardo MJ, Thornton PC, Hu KH, Galhardo RS, Beadle B, Habib A, Magner DB, Frost LS, Herman C, Hastings PJ, Rosenberg SM. The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli. Mol Microbiol 77(2):415-30, 2010. e-Pub 2010. PMID: 20497332.
Book Chapters
- Hu, KH. Spatial Transcriptomics in Inflammation, 243-279, 2023.
- Hu KH. Spatial Transcriptomics in Inflammation: Dissecting the Immune Response in 3D Tissues. In: Imaging Inflammation. S. J. Cleary and F. Man.
Patents
- Hu KH, Krummel MF. Single Cell Mapping and Transcriptome Analysis. Patent Number: US20210198722A1.
Patient Reviews
CV information above last modified July 22, 2026