Kevin M. McBride, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
Member, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX
Research Interests
.
Education & Training
Degree-Granting Education
| 2000 | Stony Brook University, Stony Brook, New York, US, Molecular and Cellular Pathology, Ph.D |
| 1994 | Worcester Polytechnic Institute, Worcester, Massachusetts, US, Biotechnology, BS |
Postgraduate Training
| 2007-2011 | Research Associate, Rockefeller University, New York, New York |
| 2002-2007 | Postdoctoral Fellow, Rockefeller University, New York, New York |
| 2001-2002 | Postdoctoral Associate, Stony Brook University, Stony Brook, New York |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2011 - 2018
Administrative Appointments/Responsibilities
Director: Recombinant Antibody Production Core, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2024
Associate Director: Science Park Summer Undergraduate Research Program in Cancer, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2014 - 2021
Other Professional Positions
Member, Center for Molecular & Cellular Toxicology, Austin, TX, 2013 - Present
Extramural Institutional Committee Activities
Member, Immunology Dept Faculty Search Committee, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, CPRIT Graduate Scholar Selection Committee, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Institutional UTMDACC Research Misconduct Committee, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, EMC Department Chair Search Advisory Committee, The University of Texas MD Anderson Cancer Center, 2023
Member, CCSG Development Therapeutics Program -- Brainstorming Retreat, The University of Texas MD Anderson Cancer Center, 2022
Senator, UTMDACC, The University of Texas MD Anderson Cancer Center, 2021 - 2024
Member, TMC3 Vivarium Think Tank, UTMDACC, The University of Texas MD Anderson Cancer Center, 2020
Member, Advisory Committee for Breeder Animal Movement, UTMDACC, The University of Texas MD Anderson Cancer Center, 2020
Member, TMC3 Think Tank, UTMDACC, The University of Texas MD Anderson Cancer Center, 2020
Member, Genetics and Epigenetics Program Community Committee, GSBS, The University of Texas MD Anderson Cancer Center, 2018 - 2024
Member, Kopchick Research Award Review Committee, The University of Texas MD Anderson Cancer Center, 2018 - 2020
Member, Recruitment Committee, Genetics and Epigenetic Program, The University of Texas MD Anderson Cancer Center, 2017 - 2018
Member, Department of Epigenetics and Molecular Carcinogenesis Faculty Search Committee, The University of Texas MD Anderson Cancer Center, 2016 - 2017
Member, Steering Committee, Epigenetics and Molecular Carcinogenesis Program, The University of Texas MD Anderson Cancer Center, 2015 - 2017
Member, Faculty Academic Review Committee (FARC), The University of Texas MD Anderson Cancer Center, 2014 - Present
Member, Postdoctoral Advisory Committee, The University of Texas MD Anderson Cancer Center, 2014 - 2017
Member, Admissions Committee, Epigenetics and Molecular Carcinogenesis Program, The University of Texas MD Anderson Cancer Center, 2013 - 2017
Member, Graduate School of Biomedical Science (GSBS) Student Scholarship Committee, The University of Texas MD Anderson Cancer Center, 2012 - 2016
Member, Faculty Senator, The University of Texas MD Anderson Cancer Center, 2012 - 2015
Member, Department of Molecular Carcinogenesis Faculty Search Committee, The University of Texas MD Anderson Cancer Center, 2012
Editorial Activities
Associate Editor, Frontiers in Immunology, 2023 - Present
Honors & Awards
| 2013 | MD Anderson Cancer Center, Leukemia SPORE Career Development Award, The University of Texas MD Anderson Cancer Center |
| 2011 | University of Texas Systems, STARS Recruitment Award, University of Texas Systems |
| 2003 - 2006 | NIH Postdoctoral Training Fellowship |
| 2002 | Aaron Janoff award for excellence in experimental pathology, Stony Brook University |
Professional Memberships
Selected Presentations & Talks
Formal Peers
- 2022. HIV and AIDS Malignancy Branch (HAMB). Invited, US.
- 2019. The University of Texas at Austin. Invited. Austin, TX, US.
- 2018. Baylor College of Medicine. Invited. Houston, TX, US.
- 2018. German Cancer Research Center (DKFZ). Invited. Heidelberg, DE.
- 2013. Stony Brook University. Invited. Stony Brook, NY, US.
- 2012. Dell Pediatric Research Institute. Invited. Austin, TX, US.
Grant & Contract Support
| Date: | 2026 - 2027 |
| Title: | Leveraging tumor-infiltrating B cells to potentiate immunotherapeutic strategies |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| ID: | RCTS 2026-00066701-Y1 |
| Date: | 2025 - 2028 |
| Title: | Targeting novel host-intrinsic and extrinsic factors to enhance melanoma therapy response |
| Funding Source: | AMRF |
| Role: | Co-I |
| ID: | R-202506-00818 |
| Date: | 2025 - 2027 |
| Title: | Pan-cancer Analysis of Convergent Immunoglobulins from Tumor-infiltrating B Cells |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | R21CA297404-A101 |
| Date: | 2025 - 2026 |
| Title: | Harnessing tertiary lymphoid structure function for improved immunotherapeutic strategies in cancer patients (Extension of Award) |
| Funding Source: | The Mark Foundation for Cancer Research |
| Role: | Co-PI |
| ID: | EDV-0000000268-EXT |
| Date: | 2023 - 2027 |
| Title: | Development of Therapeutic Binders for Novel Targets SRA1 |
| Funding Source: | Manaolana Oncology Limited |
| Role: | Co-PI |
| ID: | LS2023-00062749-MT |
| Date: | 2017 - Present |
| Title: | Three Strohm Sisters Family Foundation |
| Funding Source: | Three Strohm Sisters Family Foundation |
| Role: | PI |
| ID: | N/A |
Selected Publications
Peer-Reviewed Articles
- Mu, Y, Chen, Z, Plummer, JB, Zelazowska, M, Dong, Q, Krug, LT, McBride, K. UNG–RPA interaction governs the choice between high-fidelity and mutagenic uracil repair. Nucleic acids research 54(9), 2026. e-Pub 2026. PMID: 42137982.
- Cho HJ, Charles RL, Prysyazhna O, Arjun S, Francois AA, McBride KM, Eaton P. Protein kinase GIalpha oxidation negatively regulates antibody production by B cells. Redox Biol 87:103894, 2025. e-Pub 2025. PMID: 41109134.
- Marshall VA, Cornejo Castro EM, Goodman CA, Labo N, Liu I, Fisher NC, Moore KN, Nair A, Immonen T, Keele BF, Polizzotto MN, Uldrick TS, Mu Y, Saswat T, Krug LT, McBride KM, Lurain K, Ramaswami R, Yarchoan R, Whitby D. Sequencing of Kaposi's Sarcoma Herpesvirus (KSHV) genomes from persons of diverse ethnicities and provenances with KSHV-associated diseases demonstrate multiple infections, novel polymorphisms, and low intra-host variance. PLoS Pathog 20(7):e1012338, 2024. e-Pub 2024. PMID: 39008527.
- Mu Y, Chen Z, Plummer JB, Zelazowska MA, Dong Q, Krug LT, McBride KM. UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair. bioRxiv, 2024. PMID: 38746347.
- Hogan CH, Owens SM, Reynoso GV, Liao Y, Meyer TJ, Zelazowska MA, Liu B, Li X, Grosskopf AK, Khairallah C, Kirillov V, Reich NC, Sheridan BS, McBride KM, Gewurz BE, Hickman HD, Forrest JC, Krug LT. Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. mBio 15(2):e0299823, 2024. e-Pub 2024. PMID: 38170993.
- Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T. Author Correction: Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24. Cell Mol Immunol 21(1):100, 2024. e-Pub 2024. PMID: 38114748.
- Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T. Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24. Cell Mol Immunol 20(12):1487-1498, 2023. e-Pub 2023. PMID: 37990035.
- Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT. Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues. mSphere 8(5):e0027823, 2023. e-Pub 2023. PMID: 37747202.
- Mu Y, Zelazowska MA, Chen Z, Plummer JB, Dong Q, Krug LT, McBride KM. Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity. DNA Repair (Amst) 128:103515, 2023. e-Pub 2023. PMID: 37315375.
- Liu KJ, Zelazowska MA, McBride KM. The Longitudinal Analysis of Convergent Antibody VDJ Regions in SARS-CoV-2-Positive Patients Using RNA-Seq. Viruses 15(6), 2023. e-Pub 2023. PMID: 37376553.
- Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT. Uracil-DNA Glycosylase of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently of its Catalytic Residues. bioRxiv, 2023. e-Pub 2023. PMID: 37398059.
- Mu Y, Plummer JB, Zelazowska MA, Paul S, Dong Q, Chen Z, Krug LT, McBride KM. A Recombinant Antibody For Tracking Murine Gammaherpesvirus 68 Uracil DNA Glycosylase Expression. bioRxiv, 2023. e-Pub 2023. PMID: 37293087.
- Hogan CH, Owens SM, Reynoso GV, Kirillov V, Meyer TJ, Zelazowska MA, Liu B, Li X, Chikhalya A, Dong Q, Khairallah C, Reich NC, Sheridan B, McBride KM, Hearing P, Hickman HD, Forrest JC, Krug LT. B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo competition model. bioRxiv, 2023. e-Pub 2023. PMID: 36993230.
- Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T. Characterization of a mouse model of ICF syndrome reveals enhanced CD19 activation in inducing hypogammaglobulinemia. bioRxiv, 2023. e-Pub 2023. PMID: 36945532.
- Farria AT, Plummer JB, Salinger AP, Shen J, Lin K, Lu Y, McBride KM, Koutelou E, Dent SYR. Transcriptional activation of Myc-induced genes by Gcn5 promotes B cell lymphomagenesis. Cancer Res 80(24):5543-5553, 2020. e-Pub 2020. PMID: 33168647.
- Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride KM, Murnane JP, Bhak J, Lee S, Wood RD, Takata KI. Defining the mutation signatures of DNA polymerase θ in cancer genomes. NAR Cancer 2(3):https://academic.oup.com/narcancer/article/2/3/zcaa017/5898153, 2020. e-Pub 2020. PMID: 32885167.
- Zelazowska, MA, McBride, KM, Krug, LT. Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire. Viruses 12(8):788, 2020. e-Pub 2020.
- Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Protein Cell 11(3):214-218, 2020. e-Pub 2020. PMID: 31970665.
- Zelazowska MA, Dong Q, Plummer JB, Zhong Y, Liu B, Krug LT, McBride KM. Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire. Life Sci Alliance 3(3), 2020. e-Pub 2020. PMID: 32029571.
- Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN, Tawbi HA, Cogdill AP, Liu W, LeBleu VS, Kugeratski FG, Patel S, Davies MA, Hwu P, Lee JE, Gershenwald JE, Lucci A, Arora R, Woodman S, Keung EZ, Gaudreau PO, Reuben A, Spencer CN, Burton EM, Haydu LE, Lazar AJ, Zapassodi R, Hudgens CW, Ledesma DA, Ong S, Bailey M, Warren S, Rao D, Krijgsman O, Rozeman EA, Peeper D, Blank CU, Schumacher TN, Butterfield LH, Zelazowska MA, McBride KM, Kalluri R, Allison J, Petitprez F, Fridman WH, Sautès-Fridman C, Hacohen N, Rezvani K, Sharma P, Tetzlaff MT, Wang L, Wargo JA. B-cells and tertiary lymphoid structures promote immunotherapy response. Nature 577(7791):549-555, 2020. e-Pub 2020. PMID: 31942075.
- McBride KM, Kil H, Mu Y, Plummer JB, Lee J, Zelazowski MJ, Sebastian M, Abba MC, Aldaz CM. Wwox Deletion in mouse B Cells leads to genomic instability, neoplastic transformation and monoclonal gammopathies. Front Oncol 9:517, 2019. e-Pub 2019. PMID: 31275852.
- Dong Q, Smith KR, Oldenburg DG, Shapiro M, Schutt WR, Malik L, Plummer JB, Mu Y, MacCarthy T, White DW, McBride KM, Krug LT. Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome. MBio 9(5), 2018. e-Pub 2018. PMID: 30377280.
- Mu Y, McBride KM. Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association. Mol Cell Oncol 5(5):e1432259, 2018. e-Pub 2018. PMID: 30263937.
- Mu Y, Zelazowska MA, McBride KM. Phosphorylation Promotes Activation-Induced Cytidine Deaminase Activity at the Myc Oncogene. J Exp Med 214(12):3543-3552, 2017. e-Pub 2017. PMID: 29122947.
- Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD. Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet 13(6):e1006818, 2017. e-Pub 2017. PMID: 28570559.
- Mu Y, Chen Z, Plummer JB, Zelazowska MA, Dong Q, Krug LT, McBride KM. UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair. Nucleic Acids Res.
Patient Reviews
CV information above last modified September 08, 2026