Lavinia P. Middleton, M.D.
Department of Anatomical Pathology, Division of Pathology-Lab Medicine Div
About Dr. Lavinia P. Middleton
Dr. Middleton is a nationally recognized breast pathologist with strong interest and expertise in quality and process improvement. A leader in her field, Dr. Middleton is actively involved in clinical and transitional research and has publications in prominent pathology journals related to the morphology and clinical features of breast cancer diagnoses and quality improvement. She has published book chapters relating to breast cancer disease progression and quality improvement. Dr. Middleton’s main research focus is on lobular breast carcinoma and its associated in situ lesions including pleomorphic lobular carcinoma in situ. She has a strong history of mentorship and has mentored local high school students, undergraduates and medical school students in pathology, infectious diseases, quality, error reduction, human factors engineering, and process improvement for over two decades. Additionally, Dr. Middleton has taught at the highest level through professional societies including US and Canadian Academy of Pathology and the American Society of Clinical Pathology. From 2016 to 2019 Dr. Middleton served as the institutional Deputy Chief Medical Officer for Medical Affairs and in this capacity assisted in the credentialing, competency assessment, and metric evaluation of MD Anderson Faculty and Advanced Care Providers. Dr. Middleton has increasingly complex and varied experiences in leading teams at the interface of quality, clinical operations, and patient care. Currently Dr. Middleton serves as the Co-Chair of the institutional Professional Liability Committee.
Present Title & Affiliation
Primary Appointment
Professor, Department of Pathology, Division of Pathology-Lab Medicine Div, The University of Texas MD Anderson Cancer Center, Houston, TX
Assistant Professor, Department of Pathology/Laboratory Medicine, The University of Texas - Houston Medical School, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Clinical Interests
Breast Cancer, Triple- Negative Breast Cancer, Rare types of breast cancer to include salivary gland type and skin adnexal gland type, male breast cancer, lobular carcinoma
Education & Training
Degree-Granting Education
| 1993 | George Washington School of Medicine and Health Sciences, Washington, US, MD |
| 1989 | Yale College, New Haven, Connecticut, US, BS in Biology |
Postgraduate Training
| 2020-2020 | Strategic Planning, American College of Healthcare Executives, Chicago, Illinois |
| 2019-2019 | Promoting Professionalism, Vanderbilt Center for Patient Advocacy and Professionalism, San Diego, California |
| 2018-2018 | Value Institute for Health and Care, The University of Texas at Austin, Austin, Texas |
| 2018-2019 | Fellow, Executive Leadership in Academic Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania |
| 2017-2018 | Leadership Training, AAMC CMO Leadership Academy, American Association of Medical Colleges, Washington, D.C |
| 2012-2012 | Quality Improvement for Chairs and Chiefs, Institute for Health Care Improvement, Boston, Massachusetts |
| 2009-2009 | Faculty Leadership Academy, Graduate Leadership Course "Leading in Challenging Times", The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2007-2008 | Faculty Leadership Academy, Leadership Course, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2007-2008 | Clinical Safety & Effectiveness Course, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 1996-1997 | Fellow, Surgical Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 1996-1996 | Visiting Fellow, Surgical Pathology, Memorial Sloan Kettering Cancer Center, New York, New York |
| 1993-1996 | Resident, Anatomic Pathology, National Institute of Health, National Cancer Institute, Bethesda, Maryland |
Licenses & Certifications
| 2014 | American Board of Medical Quality |
| 2000 | TX Medical Board License |
| 1997 | American Board of Pathology, Anatomic Pathology |
| 1994 | National Board of Medical Examiners |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2004 - 2010
Assistant Professor, Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 2000 - 2004
Assistant Professor, Department of Pathology/Laboratory Medicine, The University of Texas - Houston Medical School, Houston, TX, 1999 - 2000
Staff Pathologist, NIH, NCI, Warren G. Magnuson Clinical Center, Bethesda, MD, 1997 - 1999
Administrative Appointments/Responsibilities
Clinical Consultant, Department of Cytogenetics Lab, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present
Co-Chair, Department of Strategic Operational Priority Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2023
Deputy Chief Medical Officer, Department of Division of CMO, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2019
Deputy Division Head for Quality, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2019
Divisional Director, Quality Operations, Department of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2019
Clinical Safety and Effectiveness Fellow, The University of Texas System, Austin, TX, 2011 - Present
Quality Officer, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - 2016
Medical Director, Surgical Pathology Support Services, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2012
Medical Director, Quality Assurance, Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2001 - 2015
Steering Committee, Department of Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 2000 - 2002
Other Professional Positions
Board of Directors, American Hospital of Paris Foundation, New York, NY, 2022 - Present
Member, The Leapfrog Group, Recognizing Diagnostic Excellence National Advisory Committee, Washington, DC, 2021 - 2023
Member, Centers for Disease Control, Clinical Laboratory Improvement Advisory Committee, Atlanta, GA, 2018 - 2023
Committee Chair, Medical Quality, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2018
Military or Other Governmental Service, 1996 - 1997
Military or Other Governmental Service, 1993 - 1996
Military or Other Governmental Service, 1992 - 1993
Institutional Committee Activities
Committee Co-Chair, Professional Liability Committee, 2024 - Present
Committee Member, Clinical Genomics and Biomarkers Council, 2021 - 2024
Coordinator, American College of Surgeons Site Visit Committee, 2020 - 2022
Committee Member, Search Committee, Chief Quality and Patient Safety Officer, 2018 - 2018
Member, Beaker Executive Committee, 2018 - 2022
Committee Member, Search Committee, Department of Melanoma Medical Oncology, 2018 - 2019
Member, UT System Quality Sharing Committee, 2018 - Present
Advisory Committee, Women and Minority Faculty Inclusion, 2017 - 2023
Member, Clinical Effectiveness Sub Committee, 2016 - Present
Committee Member, Patient and Blood Management Program, 2016 - 2022
Divisional Quality Officer, Quality Officer, 2016 - 2019
Committee Chair, CRC Committee, 2016 - 2016
Member, Practitioner Peer Assistance Committee, 2016 - 2024
Committee Member, Search Committee, Department of Breast Surgical Oncology, 2015 - 2016
Member, Utilization Review Subcommittee, 2015 - 2022
Committee Member, Integrated Practice Committee, 2015 - 2017
Member, Hospital Practice Committee, 2015 - 2017
Member, Quality Operations Team, 2015 - 2017
Member, Ambulatory Operations Committee, 2015 - 2015
Member, Executive Committee of the Medical Staff, 2015 - 2019
Committee Member, Federal Reporting, 2015 - 2022
Member, Institutional Patient Safety Committee, 2014 - 2020
Board Member, Secretary, UT MD Anderson Cancer Center Practice Network, 2012 - 2018
Member, Credentials Committee of the Medical Staff, 2011 - 2019
Member, Executive Billing Compliance Committee, 2010 - Present
Member, Molecular Testing Evaluation Committee, 2010 - 2012
Member, Molecular Targets and Markers Testing Facility Steering Committee, 2010 - 2012
Member, Professional Liability Committee, 2010 - Present
Executive Leader, Joint Commission Preparedness Committee, 2010 - 2019
Member, Quality Improvement Assessment Board, 2009 - 2015
Quality Officer for Department of Pathology, Quality Officer, 2009 - 2015
Expert Reviewer, Institutional Focus Review Policy, 2008 - 2009
Honors & Awards
| 2018 | President's Recognition for Faculty Excellence, UT MD Anderson Cancer Center |
| 2017 | President's Recognition for Faculty Excellence, UT MD Anderson Cancer Center |
| 2015 | President's Recognition for Faculty Excellence, UT MD Anderson Cancer Center |
| 2010 | Clinical Safety and Effectiveness Alumni Award, 1st Place, The University of Texas System, Austin, TX |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2024. Recent Advances in the Management of Lobular Breast Cancer. Invited. Breast Cancer Clinical and Transitional Research (BCCTR) Conference. Houston, Texas, US.
- 2024. 20th Annual Oncology Update: Advances and Controversies Panelist Discussion. Invited. 20th Annual Oncology Update: Advances and Controversies. Steamboat Springs, Colorado, US.
- 2023. Normal Breast Histology and Breast Pathology. Conference. Normal Breast Histology and Breast Pathology. Houston, TX, US.
- 2018. Joint Ticktocker Meeting. Conference. Joint Ticktocker Meeting. Houston, TX, US.
- 2016. Internal Medicine and Cancer Survivorship Grand Rounds. Conference. Internal Medicine and Cancer Survivorship Grand Rounds. Houston, TX, US.
- 2016. Office for Women and Minority Faculty Inclusion: What can we do for you?. Conference. Office for Women and Minority Faculty Inclusion: What can we do for you?. Houston, TX, US.
- 2016. Update on Lobular Lesions of the Breast. Conference. Update on Lobular Lesions of the Breast. Houston, TX, US.
- 2013. Papillary Neoplasms of the Breast. Conference. Papillary Neoplasms of the Breast. Houston, TX, US.
- 2007. Laser Capture Micro-dissection: the Best Ways to Obtain, Process, and Store DCIS Samples for Future Use. Conference. Laser Capture Micro-dissection: the Best Ways to Obtain, Process, and Store DCIS Samples for Future Use. Houston, TX, US.
- 2007. Guidelines to Improve Her2 Neu Testing and Interpretation. Conference. Guidelines to Improve Her2 Neu Testing and Interpretation. Houston, TX, US.
- 2003. Lobular carcinoma in situ. Updates and challenges. Conference. Lobular carcinoma in situ. Updates and challenges. Houston, TX, US.
- 2002. Cancer Symposium. Conference. Cancer Symposium. Houston, TX, US.
- 2001. Pathology. Conference. Pathology. Houston, TX, US.
Regional Presentations
- 2011. Molecular Diagnostic Lab Pre-analytic Improvements. Conference. Molecular Diagnostic Lab Pre-analytic Improvements. San Antonio, TX, US.
- 2010. Pre-analytic Process Improvements for Molecular Testing Improve Turn Around Time for Results. Conference. Pre-analytic Process Improvements for Molecular Testing Improve Turn Around Time for Results. Austin, TX, US.
National Presentations
- 2025. Controversies in Oncology, Lobular Lesions. Panelist. 21st Oncology Updates: Advances and Controversies. Steamboat Springs, CO, US.
- 2024. Breast Case Presentations. Conference. 20th Oncology Update: Advances and Controversies. Steamboat Springs, CO, US.
- 2020. Controversies in Oncology, Lobular Lesions. Conference. 18th Oncology Update: Advances and Controversies. Steamboat Springs, CO, US.
- 2019. Building the Next Generation of Academic Physicians. Conference. Building the Next Generation of Academic Physicians. Houston, TX, US.
- 2019. Controversies in Oncology, Lobular Lesions. Conference. 17th Oncology Update: Advances and Controversies. Breckenridge, CO, US.
- 2018. Path to Leadership. Conference. 7th Annual Postdoctoral Career Symposium. Houston, TX, US.
- 2018. Controversies in Oncology, Lobular Lesions. Conference. 16th Oncology Update: Advances and Controversies. Steamboat Springs, CO, US.
- 2017. Controversies in Oncology, Lobular Lesions. Conference. 15th Oncology Updates: Advances and Controversies. Houston, TX, US.
- 2016. Quality Improvement and Advocacy. Conference. Quality Improvement and Advocacy. Houston, TX, US.
- 2016. Update on Lobular Carcinoma in Situ. Conference. Update on Lobular Carcinoma in Situ. Houston, TX, US.
- 2016. Longitudinal Study of LCIS on CNB. Conference. 105 th Annual Meeting of the United States & Canadian Academy of Pathology. Seattle, WA, US.
- 2016. The Value of Secondary Pathology Review in the ADCC. Conference. ASCO Quality Conference. Phoenix, AZ, US.
- 2016. Getting the Diagnosis Right. the first time. Conference. Medical Oncology and Hematology 2016. Houston, TX, US.
- 2016. Value of Second Pathology Opinion. Conference. Cancer Network. Houston, TX, US.
- 2016. Lessons Learned from Cerner Lab Implementation. Conference. Lessons Learned from Cerner Lab Implementation. Houston, TX, US.
- 2016. Lobular Carcinoma of the Breast. Conference. 14th Oncology Update: Advances and Controversies. Steamboat, CO, US.
- 2015. Quality Initiatives in Pathology:Providing the Right Diagnosis at the Right Time. Conference. 16th Annual International Summit in Improving Patient Care in the Office Practice and the Community. Houston, TX, US.
- 2014. Process Improvements in Molecular Lab. Conference. Shared Vision Conference. San Antonio, TX, US.
- 2014. Practice of Breast Pathology in 2014 and Beyond. Conference. 103rd Annual Meeting of the United States & Canadian Academy of Pathology. San Diego, CA, US.
- 2013. Practice of Breast Pathology in 2013 and Beyond. Conference. 102nd Annual Meeting of the United States and Canadian Academy of Pathology. Baltimore, MD, US.
- 2012. Practical Approach to Neoplastic Lesions of the Breast-Problems, Solutions and Perspectives. Conference. ASCP 2012 Weekend of Pathology: Chicago. Chicago, IL, US.
- 2011. Pathology of Triple-Negative Breast Cancer. Conference. The Jean Sindab 4th Annual Triple-Negative Breast Cancer Symposium. Atlanta, GA, US.
- 2011. Lobular Carcinoma in Situ: Diagnosis, Reporting, and Management in 2011 Pathology in the 21st Century. Conference. Diagnostic Pathology Course. Houston, TX, US.
- 2007. LCIS- Should we Change Treatment Strategy Again?. Conference. 7th Annual Oncology Update: Advances and Controversies. Steamboat Springs, CO, US.
- 2005. Breast Cancer in Special Populations. Conference. Lynn Sage Conference. Chicago, IL, US.
- 2005. Pathology of breast cancer in African-American women. Conference. 7th Annual African-American National Breast Cancer Conference. Houston, TX, US.
- 2003. Breast Cancer Aggressiveness and Racial Disparity. Conference. George Washington University Cancer Institute and NCI Conference. Washington, US.
- 2002. LCIS on Core Needle biopsy. When does one recommend excisional biopsy?. Conference. 91st Annual Meeting of the United States and Canadian Academy of Pathology. Chicago, IL, US.
- 2000. Evaluating Research on Breast Cancer in African American Women. Conference. Summit Meeting. Washington, US.
- 1999. Pleomorphic Lobular Carcinoma, Histology, Immunohistochemistry and Molecular Analysis. Conference. 88th Annual Meeting of United States and Canadian Academy of Pathology. San Francisco, CA, US.
- 1996. Infiltrating Micropapillary Carcinoma of the Breast. Conference. 85th Annual Meeting of United States and Canadian Academy of Pathology. Washington, US.
International Presentations
- 2014. Second Opinion Pathology Review is a Patient Safety Mechanism That Helps Reduce Error and Decrease Waste. Conference. International Forum on Quality & Safety in Health Care. Paris, FR.
- 2012. Lobular Carcinoma In Situ Controversies and Treatment Recommendations. Conference. Breast Disease Group Peking University Pathology Center. Beijing, CN.
- 2012. Practice of Breast Pathology in 2012 and Beyond - Short Course. Conference. 101st Annual Meeting of the United States and Canadian Academy of Pathology. Vancouver, CA.
- 1998. Molecular Genetic Events in the Development, Progression, and Treatment of Ovarian Cancer. Conference. XXII International Congress of the International Association of Academic and Environmental Pathology. Nice, FR.
- 1998. Evaluation of p27 and MIB-1 Expression in Parathyroid Neoplasms. Conference. XXII International Congress of the International Association of Academic And Environmental Pathology. Nice, FR.
- 1995. The Histologic Spectrum of Hemangiopericytoma. Correlation with Immunocytochemistry and Proliferative Markers. Conference. 84th Annual Meeting of United States and Canadian Academy of Pathology. Toronto, CA.
Formal Peers
- 2022. Lobular Neoplasia and normal breast histology. Visiting Grand Rounds. Visiting. Houston, TX, US.
- 2018. Lobular Neoplasia. Visiting. Houston, TX, US.
- 2018. Career Impact of Protégée Program. Visiting. Houston, TX, US.
- 2017. Quality. Visiting. Houston, TX, US.
- 2016. Quality in Lab Operations, Grand Rounds. Visiting. Columbus, OH, US.
- 2013. Quality of Prognostic/Predictive Markers. Visiting. Houston, TX, US.
- 2013. Important Topics in Breast Pathology. Visiting. Houston, TX, US.
- 2012. Lobular Lesions Breast Difficult Case Review. Visiting. Beijing, CN.
- 2011. Breast Pathology Lobular Lesions of the breast 2011. Visiting. Houston, TX, US.
- 2009. Atypical hyperplasias and in situ carcinoma. Visiting. Houston, TX, US.
- 2006. A Survey of Breast Pathology. Visiting. Houston, TX, US.
- 2006. Pathology of Breast Cancer in Special Populations. Visiting. Houston, TX, US.
Grant & Contract Support
| Date: | 2024 - Present |
| Title: | Phase II study of REPotrectinib with or without fulvestrant in patients with hormone receptor-positive human epidermal growth factor 2-negative metastatic invasive LObular carcinoma who received a prior endocrine Therapy in combination with cyclin-dependent kinase 4 and 6 inhibitor (REPLOT trial) |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| ID: | 2024-0099 REPLOT / BMS |
| Date: | 2023 - 2028 |
| Title: | Medical Students Summer in Oncology at Anderson Research (Med Students SOAR) program |
| Funding Source: | NIH/NCI |
| Role: | Faculty Mentor |
| ID: | 1 R25 CA265800-01A1 |
| Date: | 2016 - Present |
| Title: | Breast / Ovarian Moonshot Prevention Project C: Preventing Breast Cancer in Women with Precancerous Breast Lesions: Implementing a Program Improvement Project to Maximize Breast Cancer Preventive Therapy |
| Funding Source: | MoonShot |
| Role: | Collaborator |
| Date: | 2010 - 2012 |
| Title: | Optical imaging of breast tumor margins: a prospective trial |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2007 - 2012 |
| Title: | Bench-to-Bedside Applications in Photonics-based Imaging |
| Funding Source: | Department of Defense (DOD) |
| Role: | Collaborator |
| ID: | W81XWH-06BCRP-EHSA |
| Date: | 2004 - 2005 |
| Title: | GeneSearch Breast Lymph Node Assay for Intra-Operative Molecular Test |
| Funding Source: | Pivotal Study |
| Role: | Collaborator |
| ID: | CS2004-00011795SP |
| Date: | 2003 - 2005 |
| Title: | Investigation of Alpha 6 Beta 4 with Integrin as a prognostic marker in breast cancer |
| Funding Source: | DAMD |
| Role: | Collaborator |
| ID: | BCTR0202043 |
| Date: | 2003 - 2007 |
| Title: | Determination of extent of residual tumor following neoadjuvant chemotherapy for operable breast cancer |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2001 - 2005 |
| Title: | A preliminary study to explore subareolar injection as the site for lymphatic mapping and sentinel lymph node biopsy in patients with breast cancer |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | IDOI-538 |
| Date: | 2001 - 2005 |
| Title: | Clinical and Biological Significance of Cystatin C and M Expression in Breast Cancer |
| Funding Source: | Breast Cancer Army Research Grant |
| Role: | Collaborator |
Selected Publications
Peer-Reviewed Articles
- Chen JH, Warneke CL, Middleton LP, Singh P, Kuerer HM, Hunt KK, Martinez AL, Litton JK, Oke OC, Johnson HM. Complication Rates are Low After Invasive Procedures on the Lactating Breast in Patients Treated for Breast Cancer During Pregnancy. Ann Surg Oncol, 2025. PMID: 40676422.
- Middleton LP, Perkins GH, Whitman GJ, Mouabbi JA, Bevers TB, Min Y, Hunt KK. Immediate and ipsilateral recurrence rates and treatment recommendations for patients with pleomorphic and florid lobular carcinoma in situ. Breast Cancer Res 213(2):225-235, 2025. e-Pub 2025. PMID: 40637967.
- Wang L, El-Naggar AK, Ding Q, Yu W, Middleton LP. Pattern of SOX9 expression in pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and matrix-producing metaplastic carcinoma of the breast lends support to common biology. Virchows Arch, 2025. PMID: 40583066.
- Ye, Q, Law, T, Klippel, D, Albarracin, C, Chen, H, Contreras, A, Ding, Q, Huo, L, Khazai, L, Middleton, LP, Resetkova, E, Sahin, AA, Sun, H, Sweeney, K, Symmans, WF, Wu, Y, Yoon, EC, Krishnamurthy, S. Prospective and Retrospective Analysis of Whole-Slide Images of Sentinel and Targeted Lymph Node Frozen Sections in Breast Cancer. Modern Pathology 38(4), 2025. e-Pub 2025. PMID: 39788205.
- Ye Q, Ye Q, Law T, Law T, Klippel D, Klippel D, Albarracin C, Albarracin C, Chen H, Chen H, Contreras A, Contreras A, Ding Q, Ding Q, Huo L, Huo L, Khazai L, Khazai L, Middleton L, Middleton L, Resetkova E, Resetkova E, Sahin A, Sahin A, Sun H, Sun H, Sweeney K, Sweeney K, Symmans W, Symmans W, Wu Y, Wu Y, Krishnamurthy S, Krishnamurthy S. Prospective and retrospective analysis of whole slide images of sentinel and targeted lymph node frozen sections in breast cancer. Mod Pathol, 2025. e-Pub 2025.
- Waugh S, Deavers M, Middleton LP. Metastatic Lobular Carcinoma Involving the Vulva as Initial Presentation of Disease in a Patient with Dense Breast Tissue. Int J Pathol Clin Res 10(2), 2024. e-Pub 2024.
- Ye Q, Chen H, Han C, Peng Y, Huang X, Sun H, Wu Y, Albarracin CT, Middleton LP, Sahin AA, Huo L, Ding Q. Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of breast: pan-Trk in various subtypes of breast carcinoma. J Clin Pathol 77(11):751-755, 2024. e-Pub 2023. PMID: 37586834.
- Liang, TZ, Ding, Q, Middleton, LP, Wu, Y, Sahin, AA. Characteristics of secretory breast carcinoma with extensive in situ carcinoma components. Human Pathology Reports 37, 2024. e-Pub 2024.
- Liang TZ, Ding Q, Middleton LP, Wu Y, Sahin AA. Characteristics of secretory breast carcinoma with extensive in situ carcinoma components: Clinical and histopathologic analysis. Human Pathology Reports 37, 2024. e-Pub 2024.
- Olayinka, O, Cox, SE, Nasrazadani, A, Resetkova, E, Ivan, D, Middleton, LP. Invasive Carcinoma With Skin Adnexal Trichilemmal Hair Follicular Differentiation Occurring in the Breast. International Journal of Surgical Pathology 32(4):796-802, 2024. e-Pub 2024. PMID: 37525555.
- Chung HL, Middleton LP, Sun J, Whitman GJ. Immediate and delayed risk of breast cancer associated with classic lobular carcinoma in situ and its variants. Breast Cancer Res Treat 205(3):545-554, 2024.
- Middleton LP, Salem A, Wu Y, Albarracin CT, Kalhor N, Peng Y, Huang X, Aung P, Chen H, Sahin A, Ding Q. A Comparative Evaluation of TRPS1 and GATA3 in adenoid cystic, secretory, and acinic cell carcinomas of the breast and salivary gland. Human Pahtology 145:42-47, 2024. e-Pub 2024. PMID: 38262580.
- Li, C, Warner, MT, Middleton, LP, Mouhayar, E, Patel, B, Bashoura, L, Faiz, S. Pulmonary Tumor Thrombotic Microangiopathy in a Patient With Dyspnea and Triple-Negative Breast Cancer. Annals of Internal Medicine Clinical Cases 2(12), 2023. e-Pub 2023.
- Chang L, Warner MT, Middleton LP, Patel B, Bashoura L, Faiz SA. Pulmonary Tumor Thrombotic Microangiopathy in a Patient With Dyspnea and Triple-Negative Breast Cancer. Annals of Internal Medicine: Clinical Cases, 2023. e-Pub 2023. PMID: 38371170.
- Mouabbi, JA, Singareeka Raghavendra, A, Bassett Jr, R, Christgen, M, Middleton, LP, Teshome, M, Nasrazadani, A, Hortobagyi, GN, Hassan, A, Tripathy, D, Layman, RM. Absence of lobular carcinoma in situ is a poor prognostic marker in invasive lobular carcinoma. European Journal of Cancer 191, 2023. e-Pub 2023. PMID: 37573674.
- Xie, CL, Whitman, GJ, Middleton, LP, Bevers, TB, Bedrosian, I, Chung, H. Isolated Flat Epithelial Atypia. Journal of Breast Imaging 5(5):575-584, 2023. e-Pub 2023. PMID: 37744722.
- Salem A, Chung HL, LP Middleton. Primary porocarcinoma of the nipple with metastasis: A case report of a rare entity with molecular analysis and imaging correlation. Human Pathology Reports, 2023. e-Pub 2023.
- Olayinka O, Cox, SE, Nasrazadani A, Resetkova E, Ivan D, LP Middleton. Invasive Carcinoma With Skin Adnexal Trichilemmal Hair Follicular Differentiation Occurring in the Breast: A Case Report With Detailed Immunohistochemical and Molecular Analysis. Intl J of Surg Pathol, 2023. e-Pub 2023.
- Singareeka Raghavendra A, Bassett Jr RL, Christgen M, Middleton LP, Teshome M, Nasrazadani A, Hortobagyi GN, Hassan A, Tripathy D, Layman RM. Absence of Lobular Carcinoma In Situ is a Poor Prognostic Marker in Invasive Lobular Carcinoma. European Journal of Cancer 191, 2023. e-Pub 2023.
- Xie C, Whitman G, Middleton LP, Bevers T, Bedrosian I, Sun J, Chung H. Isolated Flat Epithelial Atypia: Outcomes of Radiologic Surveillance versus Surgical Excision. Journal of Breast Imaging, 2023. e-Pub 2023.
- Kang EY, Fisher SB, Middleton LP. Hidradenocarcinoma involving the male breast: Report of a case with emphasis on the differential diagnosis of invasive carcinoma with sweat gland differentiation. Human Pathology Reports 31, 2023. e-Pub 2023.
- Kim MJ, LP Middleton. Potential Diagnostic Pitfalls in Lack of Recognition of Histopathologic Changes of Breast Carcinoma Following Neoadjuvant Chemotherapy. American Journal of Surgery and Clinical Case Reports 6(5):1-3, 2023. e-Pub 2023.
- Wang J, Middleton LP. Basal-Like Atypical Ductal Hyperplasia and Basal-Like Ductal Carcinoma In Situ: Evidence for Precursor of Basal-Like Breast. International Journal of Pathology and Clinical Research 8:1-8, 2022. e-Pub 2022.
- Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q. TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma. Hum Pathol 125:97-107, 2022. e-Pub 2022. PMID: 35413381.
- Zhou P, Chang N, Abraham SC, Albarracin CT, Huo L, Chen H, Ding Q, Resetkova E, Middleton LP, Sahin AA, Bu H, Wu Y. Metastatic non-Hematopoietic Neoplasms to the Breast: A Study of 238 Cases. Hum Pathol 125:59-67, 2022. e-Pub 2022. PMID: 35447141.
- Perkins, GC, Sun, SX, Middleton, LP. Synchronous bilateral low grade adenosquamous carcinoma with imaging and pathology correlation. Human Pathology Reports 27, 2022. e-Pub 2022.
- Wang J, Wang WL, Sun H, Huo L, Wu Y, Chen H, Gan Q, Meis JM, Maloney N, Lazar AJ, Yoon EC, Albarracin CT, Krishnamurthy S, Middleton LP, Resetkova E, Yu W, Tan D, Lu W, Solis Soto LM, Wang S, Wistuba II, Parwani AV, Prieto VG, Sahin AA, Li Z, Ding Q. Expression of TRPS1 in phyllodes tumor and sarcoma of the breast. Hum Pathol 121:73-80, 2022. e-Pub 2022. PMID: 35063444.
- Perkins G, Sun S, Middleton LP. Synchronous bilateral low grade adenosquamous carcinoma with imaging and pathology correlation. Human Pathology 27, 2022. e-Pub 2022.
- Chung H, Whitman G, Leung J, Sun J, Middleton LP, LePetross H. Ultrasound Features to Differentiate COVID-19 Vaccine-Induced Benign Adenopathy from Breast Cancer Related Malignant Adenopathy. Acad Radiol. e-Pub 2022. PMID: 35296413.
- Chung HL, Tso HH, Middleton LP, Sun J, Leung JWT. Axillary Nodal Metastases in Invasive Lobular Carcinoma Versus Invasive Ductal Carcinoma: Comparison of Node Detection and Morphology by Ultrasound. AJR Am J Roentgenol 218(1):33-41, 2022. e-Pub 2021. PMID: 34319162.
- Bayani J, Poncet C, Crozier C, Neven A, Piper T, Cunningham C, Sobol M, Aebi S, Benstead K, Bogler O, Dal Lago L, Fraser J, Hilbers F, Hedenfalk I, Korde L, Linderholm B, Martens J, Middleton LP, Murray M, Kelly C, Nilsson C, Nowaczyk M, Peeters S, Peric A, Porter P, Schröder C, Rubio IT, Ruddy KJ, van Asperen C, Van Den Weyngaert D, van Deurzen C, van Leeuwen-Stok E, Vermeij J, Winer E, Giordano SH, Cardoso F, Bartlett JMS. Evaluation of multiple transcriptomic gene risk signatures in male breast cancer. NPJ Breast Cancer 7(1):98, 2021. e-Pub 2021. PMID: 34312396.
- Middleton LP, Huey RW, Medeiros LJ, Miranda RN. Follicular Dendritic Cell Sarcoma in the differential diagnosis of GATA3 positive tumors: A Case Report: Human Pathology: Case Reports 23, 2021. e-Pub 2021.
- Sheu TG, Hunt KK, Middleton LP. MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast. Breast J. e-Pub 2021. PMID: 33527629.
- Ronen S, Al-Rohil RN, Keiser E, Jour G, Nagarajan P, Tetzlaff MT, Curry JL, Ivan D, Middleton LP, Torres-Cabala CA, Gershenwald JE, Aung PP, Prieto VG. Discordance in Diagnosis of Melanocytic Lesions and Its Impact on Clinical Management. Arch Pathol Lab Med. e-Pub 2021. PMID: 33577643.
- Del Valle Estopinal M, Middleton LP, Esmaeli B, Patel KP, Nowroozizadeh S, Williams MD. Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations. Case Rep Pathol 2021:6628150, 2021. e-Pub 2021. PMID: 34804623.
- Oramas OM, Bell D, Middleton LP. Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast. Diagnostic Pathology(1746-1596):137, 2020. e-Pub 2020.
- Chung HL, Middleton LP. Breast Amyloidosis in a Dormant Plasma Cell Myeloma. Breast J. e-Pub 2020. PMID: 32939920.
- Richards D, Ayala AA, Wu Y, Middleton LP. Carcinoma in Situ Involving Sclerosing Adenosis on Core Biopsy: Diagnostic Pearls to Aid the Practicing Clinician and Avoid Overtreatment. Oncol Ther 8(1):81-89, 2020. e-Pub 2020. PMID: 32700071.
- Bouobda GT, Gonzalez CE, Phipps RA, Middleton LP. Value Added Impact of Both Point-of-Care and Laboratory Lactic Acid Analysis When Emergently Evaluating Cancer Patients. Oncol Ther. e-Pub 2020. PMID: 32700044.
- Le V, Wagar EA, Phipps RA, Del Guidice RE, Le H, Middleton LP. Improving Patient Experience of Wait Times and Courtesy Through Electronic Sign In and Notification in the Phlebotomy Clinic. Arch Pathol Lab Med 144(6):769-775, 2020. e-Pub 2020. PMID: 31755777.
- Speer ME, Adrada BE, Arribas EM, Hess KR, Middleton LP, Whitman GJ. Imaging of Intracystic Papillary Carcinoma. Curr Probl Diagn Radiol 48(4):348-352, 2019. e-Pub 2019. PMID: 30072190.
- Middleton LP, Thompson L, Starr-High E, Travis E, Kurtin D, Rodriguez A, Dmitrovsky E. Getting New Faculty into the Fold -- Fast. Physician Leadership Journal, 2018. e-Pub 2018.
- Middleton LP, Phipps R, Routbort M, Prieto V, Medeiros LJ, Riben M, Contreras A, Kelley J, Patel K, Bingham J, Wagar EA. Fifteen-Year Journey to High Reliability in Pathology and Laboratory Medicine. Am J Med Qual 33(5):1062860618759198, 2018. e-Pub 2018. PMID: 29512395.
- Brewster A, Thomas P, Brown P, Coyne R, Yan Y, Checka C, Middleton LP, Do KA, Bevers T. A System-Level Approach to Improve the Uptake of Anti-Estrogen Preventative Therapy among Women with Atypical Hyperplasia and Lobular Cancer In Situ. Cancer Prevention Research, 2018. e-Pub 2018. PMID: 29618460.
- Cardoso F, Bartlett JMS, Slaets L, van Deurzen CHM, van Leeuwen-Stok E, Porter P, Linderholm B, Hedenfalk I, Schröder C, Martens J, Bayani J, van Asperen C, Murray M, Hudis C, Middleton LP, Vermeij J, Punie K, Fraser J, Nowaczyk M, Rubio IT, Aebi S, Kelly C, Ruddy KJ, Winer E, Nilsson C, Dal Lago L, Korde L, Benstead K, Bogler O, Goulioti T, Peric A, Litière S, Aalders KC, Poncet C, Tryfonidis K, Giordano SH. Characterization of male breast cancer: Results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program. Ann Oncol. e-Pub 2017. PMID: 29092024.
- Woodward WA, Fang P, Arriaga L, Gao H, Cohen EN, Reuben JM, Valero V, Le-Petross H, Middleton LP, Babiera GV, Strom EA, Tereffe W, Hoffman K, Smith BD, Buchholz TA, Perkins GH. A Phase II Study of Preoperative Capecitabine and Concomitant Radiation in Women With Advanced Breast Cancer. Int J Radiat Oncol Biol Phys. e-Pub 2017. PMID: 28843370.
- Shannon VR, Nanda AS, Middleton LP, Faiz SA. Pulmonary Mucinous Cystadenocarcinoma presenting as Extensive Multifocal Cystic Lesions. Am J Respir Crit Care Med 195(9):1267-1268, 2017. e-Pub 2017. PMID: 28199793.
- Walls AL, Middleton LP, El-Naggar AK, Sahin AA. Basaloid Salivary Gland-Analogue Tumors of the Mammary Gland: Clinicopathologic Assessment of a Rare Sybtype. International Journal of Pathology and Clinical Research 2(3), 2016. e-Pub 2016.
- Zhang S, Huo L, Arribas E, Middleton LP. Adenomyoepithelioma of the breast with associated atypical lobular hyperplasia: a previously unrecognized association with management implications. Ann Diagn Pathol 19(1):20-3, 2015. e-Pub 2015. PMID: 25631879.
- Khazai L, Middleton LP, Goktepe N, Liu BT, Sahin AA. Breast pathology second review identifies clinically significant discrepancies in over 10% of patients. J Surg Oncol 111(2):192-7, 2015. e-Pub 2015. PMID: 25273328.
- Middleton LP, Feeley TW, Albright HW, Walters R, Hamilton SH. Second-Opinion Pathologic Review Is a Patient Safety Mechanism That Helps Reduce Error and Decrease Waste. J Oncol Pract 10(4):275-80, 2014. e-Pub 2014. PMID: 24695900.
- Middleton LP, Sneige N, Coyne R, Shen Y, Dong W, Dempsey P, Bevers TB. Most lobular carcinoma in situ and atypical lobular hyperplasia diagnosed on core needle biopsy can be managed clinically with radiologic follow-up in a multidisciplinary setting. Cancer Med 3(3):492-9, 2014. e-Pub 2014. PMID: 24639339.
- Nayak A, Carkaci S, Gilcrease MZ, Liu P, Middleton LP, Bassett RL, Zhang J, Zhang H, Coyne RL, Bevers TB, Sneige N, Huo L. Benign papillomas without atypia diagnosed on core needle biopsy: experience from a single institution and proposed criteria for excision. Clin Breast Cancer 13(6):439-49, 2013. e-Pub 2013. PMID: 24119786.
- Wagar EA, Phipps R, Del Guidice R, Middleton LP, Bingham J, Prejean C, Johnson-Hamilton M, Philip P, Le NH, Muses W. Inpatient preanalytic process improvements. Arch Pathol Lab Med 137(12):1753-60, 2013. e-Pub 2013. PMID: 24283855.
- Li X, Deavers MT, Guo M, Liu P, Gong Y, Albarracin CT, Middleton LP, Huo L. The effect of prolonged cold ischemia time on estrogen receptor immunohistochemistry in breast cancer. Mod Pathol 26(1):71-78, 2013. e-Pub 2013. PMID: 22899286.
- Middleton LP. The Diagnosis of Pleomorphic Lobular Carcinoma In Situ Warrants Complete Excision with Negative Margins. Current Breast Cancer Reports 4(2):99-101, 2012. e-Pub 2012.
- Wu Y, Mittendorf EA, Kelten C, Tucker SL, Wei W, Middleton LP, Broglio K, Buchholz TA, Hunt KK, Sahin AA. Occult axillary lymph node metastases do not have prognostic significance in early stage breast cancer. Cancer 118(6):1507-14, 2012. e-Pub 2012. PMID: 22009292.
- Tian Z, Wei B, Tang F, Wei W, Gilcrease MZ, Huo L, Albarracin CT, Resetkova E, Middleton LP, Sahin A, Xing Y, Hunt KK, Chen J, Bu H, Rashid A, Abraham SC, Wu Y. Prognostic significance of tumor grading and staging in mammary carcinomas with neuroendocrine differentiation. Hum Pathol 42(8):1169-77, 2011. e-Pub 2011. PMID: 21334720.
- Downs-Kelly E, Bell D, Perkins GH, Sneige N, Middleton LP. Clinical Implications of Margin Involvement by Pleomorphic Lobular Carcinoma In Situ. Arch Pathol Lab Med 135(6):737-43, 2011. e-Pub 2011. PMID: 21631266.
- Langsner RJ, Middleton LP, Sun J, Meric-Bernstam F, Hunt KK, Drezek RA, Yu TK. Wide-field imaging of fluorescent deoxy-glucose in ex vivo malignant and normal breast tissue. Biomed Opt Express 2(6):1514-23, 2011. e-Pub 2011.
- Arun BK, Granville LA, Yin G, Middleton LP, Dawood S, Kau SW, Kamal A, Hsu L, Hortobagyi GN, Sahin AA. Glutathione-S-Transferase-Pi Expression in Early Breast Cancer: Association With Outcome and Response to Chemotherapy. Cancer Invest 28(5):554-9, 2010. e-Pub 2010. PMID: 20210524.
- Rosbach KJ, Shin D, Muldoon TJ, Quraishi MA, Middleton LP, Hunt KK, Meric-Bernstam F, Yu TK, Richards-Kortum RR, Yang W. High-resolution fiber optic microscopy with fluorescent contrast enhancement for the identification of axillary lymph node metastases in breast cancer: a pilot study. Biomed Opt Express 1(3):911-922, 2010. e-Pub 2010. PMID: 21258518.
- Dominici LS, Kuerer HM, Babiera G, Hahn KM, Perkins G, Middleton LP, Ramirez MM, Yang W, Hortobagyi GN, Theriault RL, Litton JK. Wound Complications from Surgery in Pregnancy-Associated Breast Cancer (PABC). Breast Dis 31(1):1-5, 2010. e-Pub 2010. PMID: 20519803.
- Wagner J, Boughey JC, Garrett B, Babiera G, Kuerer H, Meric-Bernstam F, Singletary E, Hunt KK, Middleton LP, Bedrosian I. Margin assessment after neoadjuvant chemotherapy in invasive lobular cancer. Am J Surg 198(3):387-91, 2009. e-Pub 2009. PMID: 19362281.
- Boughey JC, Wagner J, Garrett BJ, Harker L, Middleton LP, Babiera GV, Meric-Bernstam F, Lucci A, Hunt KK, Bedrosian I. Neoadjuvant Chemotherapy in Invasive Lobular Carcinoma May Not Improve Rates of Breast Conservation. Ann Surg Oncol 16(6):1606-1611, 2009. e-Pub 2009. PMID: 19280264.
- Middleton LP, Price KM, Puig P, Heydon LJ, Tarco E, Sneige N, Barr K, Deavers MT. Implementation of American Society of Clinical Oncology/College of American Pathologists HER2 Guideline Recommendations in a tertiary care facility increases HER2 immunohistochemistry and fluorescence in situ hybridization concordance and decreases the number of inconclusive cases. Arch Pathol Lab Med 133(5):775-780, 2009. e-Pub 2009. PMID: 19415952.
- Loya A, Guray M, Hennessy BT, Middleton LP, Buchholz TA, Valero V, Sahin AA. Prognostic significance of occult axillary lymph node metastases after chemotherapy-induced pathologic complete response of cytologically proven axillary lymph node metastases from breast cancer. Cancer 115(8):1605-1612, 2009. e-Pub 2009. PMID: 19197997.
- Yi M, Meric-Bernstam F, Middleton LP, Arun BK, Bedrosian I, Babiera GV, Hwang RF, Kuerer HM, Yang W, Hunt KK. Predictors of contralateral breast cancer in patients with unilateral breast cancer undergoing contralateral prophylactic mastectomy. Cancer 115(5):962-71, 2009. e-Pub 2009. PMID: 19172584.
- Beadle BM, Woodward WA, Middleton LP, Tereffe W, Strom EA, Litton JK, Meric-Bernstam F, Theriault RL, Buchholz TA, Perkins GH. The impact of pregnancy on breast cancer outcomes in women
- Mathew J, Perkins GH, Stephens T, Middleton LP, Yang WT. Primary breast cancer in men: clinical, imaging, and pathologic findings in 57 patients. AJR Am J Roentgenol 191(6):1631-9, 2008. e-Pub 2008. PMID: 19020230.
- Gadre SA, Perkins GH, Sahin AA, Sneige N, Deavers MT, Middleton LP. Neovascularization in mucinous ductal carcinoma in situ suggests an alternative pathway for invasion. Histopathology 53(5):545-53, 2008. e-Pub 2008. PMID: 18983463.
- Wang H, Arun BK, Wang H, Fuller GN, Zhang W, Middleton LP, Sahin AA. IGFBP2 and IGFBP5 overexpression correlates with the lymph node metastasis in T1 breast carcinomas. Breast J 14(3):261-7, 2008. e-Pub 2008. PMID: 18373644.
- Nicholas MM, Wu Y, Middleton LP, Gilcrease MZ. Loss of myoepithelium is variable in solid papillary carcinoma of the breast. Histopathology 51(5):657-665, 2007. e-Pub 2007.
- Boughey JC, Middleton LP, Harker L, Garrett B, Fornage B, Hunt KK, Babiera GV, Dempsey P, Bedrosian I. Utility of ultrasound and fine-needle aspiration biopsy of the axilla in the assessment of invasive lobular carcinoma of the breast. Am J Surg 194(4):450-455, 2007. e-Pub 2007. PMID: 17826054.
- Middleton LP, Perkins GH, Tucker SL, Sahin AA, Singletary SE. Expression of ERalpha and ERbeta in lobular carcinoma in situ. Histopathology 50(7):875-880, 2007. e-Pub 2007.
- Woodward WA, Huang EH, McNeese MD, Perkins GH, Tucker SL, Strom EA, Middleton LP, Hahn K, Hortobagyi GN, Buchholz TA. African-American race is associated with a poorer overall survival rate for breast cancer patients treated with mastectomy and doxorubicin-based chemotherapy. Cancer 107(11):2662-2668, 2006. e-Pub 2006. PMID: 17061247.
- Oh JL, Dryden MJ, Woodward WA, Yu TK, Tereffe W, Strom EA, Perkins GH, Middleton LP, Hunt KK, Giordano SH, Oswald MJ, Domain D, Buchholz TA. Locoregional control of clinically diagnosed multifocal or multicentric breast cancer after neoadjuvant chemotherapy and locoregional therapy. J Clin Oncol 24(31):4971-4975, 2006. e-Pub 2006. PMID: 17075114.
- Hahn KM, Johnson PH, Gordon N, Kuerer H, Middleton LP, Ramirez M, Yang W, Perkins G, Hortobagyi GN, Theriault RL. Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. Cancer 107(6):1219-1226, 2006. e-Pub 2006. PMID: 16894524.
- Erguvan-Dogan B, Whitman GJ, Nguyen VA, Dryden MJ, Stafford RJ, Hazle J, McAlee KR, Phelps MJ, Ice MF, Kuerer HM, Middleton LP. Specimen radiography in confirmation of MRI-guided needle localization and surgical excision of breast lesions. AJR Am J Roentgenol 187(2):339-44, 2006. e-Pub 2006. PMID: 16861535.
- Guarneri V, Broglio K, Kau SW, Cristofanilli M, Buzdar AU, Valero V, Buchholz T, Meric F, Middleton LP, Hortobagyi GN, Gonzalez-Angulo AM. Prognostic Value of Pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors. J Clin Oncol 24(7):1037-1044, 2006. e-Pub 2006. PMID: 16505422.
- Chagpar AB, Middleton LP, Sahin AA, Dempsey P, Buzdar AU, Mirza AN, Ames FC, Babiera GV, Feig BW, Hunt KK, Kuerer HM, Meric-Bernstam F, Ross MI, Singletary SE. Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapy. Ann Surg 243(2):257-264, 2006. e-Pub 2006.
- Giordano SH, Perkins GH, Broglio K, Garcia SG, Middleton LP, Buzdar AU, Hortobagyi GN. Adjuvant systemic therapy for male breast carcinoma. Cancer 104(11):2359-2364, 2005. e-Pub 2005. PMID: 16270318.
- Chagpar A, Middleton LP, Sahin AA, Meric-Bernstam F, Kuerer HM, Feig BW, Ross MI, Ames FC, Singletary SE, Buchholz TA, Valero V, Hunt KK. Clinical outcome of patients with lymph node-negative breast carcinoma who have sentinel lymph node micrometastases detected by immunohistochemistry. Cancer 103(8):1581-1586, 2005. e-Pub 2005. PMID: 15747375.
- Maru D, Middleton LP, Wang S, Valero V, Sahin A. HER-2/neu and p53 overexpression as biomarkers of breast carcinoma in women age 30 years and younger. Cancer 103(5):900-905, 2005. e-Pub 2005. PMID: 15643600.
- Vigneswaran N, Wu J, Muller S, Zacharias W, Narendran S, Middleton LP. Expression analysis of cystatin C and M in laser-capture microdissectioned human breast cancer cells--a preliminary study. Pathol Res Pract 200(11-12):753-762, 2005. e-Pub 2005. PMID: 15792117.
- Recine MA, Deavers MT, Middleton LP, Silva EG, Malpica A. Serous carcinoma of the ovary and peritoneum with metastases to the breast and axillary lymph nodes: a potential pitfall. Am J Surg Pathol 28(12):1646-1651, 2004. e-Pub 2004. PMID: 15577686.
- Wagner AE, Middleton LP, Whitman GJ. Intracystic papillary carcinoma of the breast with invasion. AJR Am J Roentgenol 183(5):1516, 2004. e-Pub 2004. PMID: 15505330.
- Sanati S, Ayala AG, Middleton LP. Lymphoepithelioma-like carcinoma of the breast: report of a case mimicking lymphoma. Ann Diagn Pathol 8(5):309-315, 2004. e-Pub 2004. PMID: 15494940.
- Selinko VL, Middleton LP, Dempsey PJ. Role of sonography in diagnosing and staging invasive lobular carcinoma. J Clin Ultrasound 32(7):323-332, 2004. e-Pub 2004. PMID: 15293298.
- Yared MA, Middleton LP, Meric F, Cristofanilli M, Sahin AA. Expression of c-kit proto-oncogene product in breast tissue. Breast J 10(4):323-327, 2004. e-Pub 2004. PMID: 15239791.
- Shahar KH, Hunt KK, Thames HD, Ross MI, Perkins GH, Kuerer HM, Strom EA, McNeese MD, Meric F, Schechter NR, Sahin AA, Middleton LP, Buchholz TA. Factors predictive of having four or more positive axillary lymph nodes in patients with positive sentinel lymph nodes: implications for selection of radiation fields. Int J Radiat Oncol Biol Phys 59(4):1074-1079, 2004. e-Pub 2004. PMID: 15234041.
- McGregor DK, Whitman GJ, Middleton LP. Myolipoma of the breast: mammographic, sonographic, and pathologic correlation. Breast J 10(3):259-260, 2004. e-Pub 2004. PMID: 15125757.
- Ivan D, Selinko V, Sahin AA, Sneige N, Middleton LP. Accuracy of core needle biopsy diagnosis in assessing papillary breast lesions: histologic predictors of malignancy. Mod Pathol 17(2):165-171, 2004. e-Pub 2004. PMID: 14631369.
- Middleton LP, Amin M, Gwyn K, Theriault R, Sahin A. Breast carcinoma in pregnant women: assessment of clinicopathologic and immunohistochemical features. Cancer 98(5):1055-1060, 2003. e-Pub 2003. PMID: 12942575.
- Dogan BE, Whitman GJ, Middleton LP, Phelps M. Intracystic papillary carcinoma of the breast. AJR Am J Roentgenol 181(1):186, 2003. e-Pub 2003. PMID: 12818855.
- Ramalingam P, Middleton LP, Tamboli P, Troncoso P, Silva EG, Ayala AG. Invasive micropapillary carcinoma of the breast metastatic to the urinary bladder and endometrium: diagnostic pitfalls and review of the literature of tumors with micropapillary features. Ann Diagn Pathol 7(2):112-119, 2003. e-Pub 2003. PMID: 12715337.
- Diaz LK, Hunt K, Ames F, Meric F, Kuerer H, Babiera G, Ross M, Singletary E, Middleton LP, Symmans WF, Krishnamurthy S, Sahin A, Sneige N, Gilcrease MZ. Histologic localization of sentinel lymph node metastases in breast cancer. Am J Surg Pathol 27(3):385-389, 2003. e-Pub 2003. PMID: 12604895.
- Gupta D, Middleton LP, Whitaker MJ, Abrams J. Comparison of fluorescence and chromogenic in situ hybridization for detection of HER-2/neu oncogene in breast cancer. Am J Clin Pathol 119(3):381-387, 2003. e-Pub 2003. PMID: 12645340.
- Middleton LP, Grant S, Stephens T, Stelling CB, Sneige N, Sahin AA. Lobular carcinoma in situ diagnosed by core needle biopsy: when should it be excised?. Mod Pathol 16(2):120-129, 2003. e-Pub 2003. PMID: 12591964.
- Sneige N, Wang J, Baker BA, Krishnamurthy S, Middleton LP. Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol 15(10):1044-1050, 2002. e-Pub 2002. PMID: 12379750.
- Solorzano CC, Middleton LP, Hunt KK, Mirza N, Meric F, Kuerer HM, Ross MI, Ames FC, Feig BW, Pollock RE, Singletary SE, Babiera G. Treatment and Outcome of Patients with Intracystic Papillary Carcinoma of the Breast. Am J Surg 184(4):364-368, 2002. e-Pub 2002. PMID: 12383904.
- Gupta D, Wolf JA, Rubenchik IA, Middleton LP. Diagnostic pitfalls in fine needle aspiration cytology of atypical apocrine metaplasia in a breast lesion. A case report. Acta Cytol 46(4):749-752, 2002. e-Pub 2002. PMID: 12146046.
- Gupta D, Croitoru CM, Ayala AG, Sahin AA, Middleton LP. E-cadherin immunohistochemical analysis of histiocytoid carcinoma of the breast. Ann Diagn Pathol 6(1):141-147, 2002. e-Pub 2002. PMID: 12089723.
- Wang J, Buchholz TA, Middleton LP, Allred DC, Tucker SL, Kuerer HM, Esteva FJ, Hortobagyi GN, Sahin AA. Assessment of histologic features and expression of biomarkers in predicting pathologic response to anthracycline-based neoadjuvant chemotherapy in patients with breast carcinoma. Cancer 94(12):3107-3114, 2002. e-Pub 2002. PMID: 12115341.
- Middleton LP, Vlastos G, Mirza NQ, Eva S, Sahin AA. Multicentric mammary carcinoma: evidence of monoclonal proliferation. Cancer 94(7):1910-1916, 2002. e-Pub 2002. PMID: 11932891.
- Yared MA, LP M, Smith TL, Kim HW, Ross MI, Hunt KK, Sahin AA. Recommendations for sentinel lymph node processing in breast cancer. Am J Surg Pathol 26(3):377-382, 2002. e-Pub 2002.
- Yared M, Middleton LP, Sahin AA. Sentinel Lymph Node Histopathology in Breast Cancer. Am J Surg Pathol 26:1368, 2002. e-Pub 2002.
- Gupta D, Merino MI, Farhood A, Middleton LP. Metastases to breast simulating ductal carcinoma in situ: report of two cases and review of the literature. Ann Diagn Pathol 5(1):15-20, 2001. e-Pub 2001.
- Lei JY, Middleton LP, Guo XD, Duray PH, McWilliams G, Linehan WM, Merino MJ. Pigmented renal clear cell carcinoma with melanocytic differentiation. Hum Pathol 32(2):233-236, 2001. e-Pub 2001.
- Middleton LP, Palacios DM, Bryant BR, Krebs P, Otis CN, Merino MJ. Pleomorphic lobular carcinoma: morphology, immunohistochemistry, and molecular analysis. Am J Surg Pathol 24(12):1650-1656, 2000. e-Pub 2000.
- Brown MR, Chuaqui R, Vocke CD, Berchuck A, Middleton LP, Emmert-Buck MR, Kohn EC. Allelic loss on chromosome arm 8p: analysis of sporadic epithelial ovarian tumors. Gynecol Oncol 74(1):98-102, 1999. e-Pub 1999.
- Sandor V, Reed E, Sarosy G, Middleton LP, Davis P, Kohn E. Synchronous inflammatory breast cancer and advanced ovarian carcinoma: a case with prolonged disease-free survival. Ann Oncol 10(5):585-588, 1999. e-Pub 1999.
- Middleton LP, Tressera F, Sobel ME, Bryant BR, Alburquerque A, Grases P, Merino MJ. Infiltrating micropapillary carcinoma of the breast. Mod Pathol 12(5):499-504, 1999. e-Pub 1999.
- Middleton LP, Merino MJ, Popok SM, Ordonez NG, Ayala AG, Ro JY. Male adnexal tumour of probable Wolffian origin occurring in a seminal vesicle. Histopathology 33:269-274, 1998. e-Pub 1998.
- Quezado MM, Middleton LP, Bryant B, Lane K, Weiss SW, Merino MJ. Allelic loss on chromosome 22q in epithelioid sarcomas. Hum Pathol 29(6):604-608, 1998. e-Pub 1998.
- Middleton LP, Duray PH, Merino MJ. The Historical Spectrum of Hemangiopericytoma: Application of Immunohistochemical Analysis Including Proliferative Markers to Facilitate Diagnosis and Predict Prognosis. Hum Pathol 29(6):636-640, 1998. e-Pub 1998.
- Movsas B, Barrows MC, Steinberg SM, Middleton LP, Okunieff P, Jaffe ES, Epstein AH. Response during radiotherapy may be associated with outcome in mediastinal Hodgkin's disease. Radiat Oncol Investig 6(5):216-225, 1998. e-Pub 1998.
Invited Articles
- Middleton LP. Commentary on: Tubular carcinoma of the breast: further evidence to support its excellent prognosis. Breast Diseases: A Year Book Quarterly 22(1):33-34, 2011. e-Pub 2011.
- Middleton LP. Commentary on: Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type. Breast Diseases: A Year Book Quarterly 22(2):154-155, 2011. e-Pub 2011.
- Middleton LP. Commentary on: Tubular carcinoma of the breast: results of a large contemporary series. Breast Diseases: A Year Book Quarterly 21(1):53, 2010. e-Pub 2010.
- Middleton LP. Commentary on: Tumor characteristics and patient outcomes are similar between invasive lobular and mixed invasive ductal/lobular breast cancers but differ from pure invasive ductal breast cancers. Breast Diseases: A Year Book Quarterly 21(1):44-45, 2010. e-Pub 2010.
- Middleton LP. Commentary on: Histologic associations and long-term cancer risk in columnar cell lesions of the breast: a retrospective cohort and a nested case-control study. Breast Diseases: A Year Book Quarterly 20(2):169-170, 2009. e-Pub 2009.
- Middleton LP. Commentary on: Needle core biopsy in the diagnosis of phyllodes neoplasm. Breast Diseases: A Year Book Quarterly 19(1):50, 2008. e-Pub 2008.
- Middleton LP. Commentary on: Age-related lobular involution and risk of breast cancer. Breast Diseases: A Year Book Quarterly 19(1):50-51, 2008. e-Pub 2008.
- Middleton LP. Commentary on: Should the extent of lobular neoplasia on core biopsy influence the decision for excision?. Breast Diseases: A Year Book Quarterly 19(2):145-146, 2008. e-Pub 2008.
- Middleton LP. Commentary on: E-Cadherin status in breast cancer correlates with histologic type but does not correlate with established prognostic parameters. Breast Diseases: A Year Book Quarterly 18(1):66, 2007. e-Pub 2007.
- Middleton LP. Commentary on: Preoperative profiling of symptomatic breast cancer by diagnostic core biopsy. Breast Diseases: A Year Book Quarterly 18(1):66, 2007. e-Pub 2007.
- Middleton LP. Commentary on: Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity. Breast Diseases: A Year Book Quarterly 17(3):241, 2006. e-Pub 2006.
- Middleton LP. Commentary on: Placental Cadherin and the Basal Epithelial Phenotype of BRCA1-Related Breast Cancer. Breast Diseases: A Year Book Quarterly 17(2):151, 2006. e-Pub 2006.
- Middleton LP. Commentary on: Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype. Breast Diseases: A Year Book Quarterly 17(2):152, 2006. e-Pub 2006.
- Middleton LP. Commentary on: Breast Conservation Therapy for Invasive Lobular Carcinoma: The Impact of Lobular Carcinoma In Situ in the Surgical Specimen on Local Recurrence and Axillary Node Status. Breast Diseases: A Year Book Quarterly 16(2):178, 2005. e-Pub 2005.
- Middleton LP. Commentary on: Clonal analysis of bilateral mammary carcinomas by clinical evaluation and partial allelotyping. Breast Diseases: A Year Book Quarterly 15(2):162, 2004. e-Pub 2004.
- Middleton LP. Commentary on: False-negative core needle biopsies of the breast: an analysis of clinical, radiologic, and pathologic findings in 27 consecutive cases of missed breast cancer. Breast Diseases: A Year Book Quarterly 15(1):45, 2004. e-Pub 2004.
- Middleton LP. Commentary on: Correlation of tumor volume and surface area with lymph node status in patients with multifocal/multicentric breast carcinoma. Breast Diseases: A Year Book Quarterly 15(3):277-278, 2004. e-Pub 2004.
- Middleton LP. Commentary on: Utility of four-quadrant random sections in mastectomy specimens. Breast Diseases: A Year Book Quarterly 15(2):159-160, 2004. e-Pub 2004.
- Middleton LP. Commentary on: Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategies. Breast Diseases: A Year Book Quarterly 15(2):161, 2004. e-Pub 2004.
- Middleton LP. Commentary on: Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: twelve-year observations concerning lobular carcinoma in situ. Breast Diseases: A Year Book Quarterly 15(3):274-275, 2004. e-Pub 2004.
- Middleton LP. Commentary on: The finding of invasive cancer after a preoperative diagnosis of ductal carcinoma-in-situ: causes of ductal carcinoma-in-situ underestimates with stereotactic 14-gauge needle biopsy. Breast Diseases: A Year Book Quarterly 15(2):161, 2004. e-Pub 2004.
- Middleton LP. Commentary on: Does core needle breast biopsy accurately reflect breast pathology?. Breast Diseases: A Year Book Quarterly 15(3):280, 2004. e-Pub 2004.
- Middleton LP. Commentary on: P-cadherin as a marker in the differential diagnosis of breast lesions. Breast Diseases: A Year Book Quarterly 15(1):47, 2004. e-Pub 2004.
- Middleton LP. Commentary on: Excisional biopsy should be performed if lobular carcinoma in situ is seen on needle core biopsy. Breast Diseases: A Year Book Quarterly 14(1):49, 2003. e-Pub 2003.
- Middleton LP. Commentary on: Pathologic analysis of tumor size and lymph node status in multifocal/multicentric breast carcinoma. Breast Diseases: A Year Book Quarterly 13(4):345, 2003. e-Pub 2003.
- Perkins GH, Middleton LP, Buchholz TA. Commentary on: Male Breast Carcinoma, Improving outcomes with optimal local regional treatment. Breast Diseases: A Year Book Quarterly, 2000. e-Pub 2000.
Review Articles
- Kuerer HM, Albarracin CT, Yang WT, Cardiff RD, Brewster AM, Symmans WF, Hylton NM, Middleton LP, Krishnamurthy S, Perkins GH, Babiera G, Edgerton ME, Czerniecki BJ, Arun BK, Hortobagyi GN. Ductal Carcinoma In Situ: State of the Science and Roadmap to Advance the Field. J Clin Oncol 27(2):279-88, 2009. e-Pub 2009. PMID: 19064970.
- Middleton LP, Chen V, Perkins GH, Pinn V, Page D. Histopathology of breast cancer among African-American women. Cancer 97(1):253-257, 2003. e-Pub 2003. PMID: 12491489.
Editorials
- Perkins GH, Middleton LP. Male breast carcinoma, improving outcomes with optimal local regional treatment. Breast Diseases, 2021.
- Perkins GH, Middleton LP. Breast cancer in men. BMJ 327(7409)(7409):239-240, 2003. PMID: 12896911.
Abstracts
- Salem A, Wu Y, Ding Q, Middleton LP. Impact of NOTCH1 expression in primary breast adenoid cystic carcinoma. J Clin Pathol 78(8):548-553, 2025. e-Pub 2024. PMID: 38471758.
- Wang L, Chen H, Fei A, Zhang YH, Middleton LP, Krishnamurthy S, Huo L, Sahin A, Ding Q. GATA3 and TRPS1 Expression in Follicular Dendritic Cell Sarcoma. United States and Canadian Academy of Pathology 105, 2025. e-Pub 2025.
- Chung, HL, Middleton LP, Sun J, Whitman GJ. Immediate and delayed risk of breast cancer associated with classic lobular carcinoma in situ and its variants. Breast Cancer Research and Treatment 205(3):545-554, 2024. e-Pub 2024. PMID: 38472593.
- Ye Q, Klippel D, Albarracin C, Chen H, Contreras A, Ding Q, Huo L, Khazai L, Middleton LP, Resetkova E, Sahin A, Sun H, Sweeney K, Symmans W, Wu Y, Krishnamurthy S. A Prospective Study of Real Time Whole Slide Imaging of Frozen Sections for Intraoperative Evaluation of Axillary Sentinel Lymph Nodes in Breast Cancer. USCAP 113th Annual Meeting Bringing Education To Life 104(3):S321-22, 2024. e-Pub 2024.
- Salem A, Han C, Wu Y, Albarracin C, Middleton L, Chen H, Sahin A, Ding Q. A Comparative Evaluation of TRPS1 in Adenoid Cystic, Acinic Cell, and Secretory Carcinomas of the Breast and Salivary Glands. Presented at the USCAP 112th Annual Meeting 103(3), 2023. e-Pub 2023.
- Pavandeep G, Middleton L. Comparative Transcriptomic Analyses Distinguish Cutaneous Squamoid Eccrine Ductal Carcinomas from Low-Grad Adenosquamous Carcinomas of the Breast. Presented at the USCAP 112th Annual Meeting 103(3), 2023. e-Pub 2023.
- Salem A, Wu Y, Ding Q, Middleton L, Zhang J, Keiser E, Ding Q, Li Z, Duose D, Hernandez S, Arrechedera C, Aung P, Torres-Cabala C, Curry J, Cho W, Prieto V, Ivan D, Nagarajan P. Prognostic Impact of NOTCH1 Expression in Primary Breast Adenoid Cystic Carcinoma. Presented at the USCAP 112th Annual Meeting 103(3), 2023. e-Pub 2023.
- Yoon E, Li Z, Huo L, Gan Q, Middleton LP, Sahin A, Ding Q. Expression of TRPS1, SOX10 and GATA3 in Different Subtypes of Metaplastic Breast Carcinoma. Modern Pathology 35:214-215, 2022. e-Pub 2022.
- Wang J, Middleton LP. Basal-Like Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ: Evidence for Precursors of Basal-Like Invasive Ductal Carcinoma. Modern Pathology 35:204-205, 2022. e-Pub 2022.
- Ronen S, Al-Rohil R, Elizabeth Keiser E, Jour G, Nagarajan P, Tetzlaff M, Curry J, Ivan D, Middleton LP, Torres-Cabala C, Aung P, Prieto VP. Discordance in Diagnosis of Melanocytic Lesions and its Impact on Clinical Management: A Melanoma Referral Center Experience With 1521 Cases. Arch Pathol Lab Med 145, 2021. e-Pub 2021.
- Middleton LP, Mayo TL, Spinks TE, Cheney R, Chu P, Cooper HS, Dintzis S, Ehya H, Fletcher CD, Gerwirtz A, Magliocco AM, Martin SE, Rosenberg AE, Sherrod A, Tan LK, Wood BL, Walters RS. The value of secondary pathology review. Presented at ASCO Quality 2016 J Clin Oncol 34, 2016 (suppl 7S; abstr 6), 2016. e-Pub 2016.
- Middleton LP. Proven Methods for Implementation of a Cross Functional Quality Improvement Plan by Empowering Trainees and Using a Team Approach to Impact Patient Care. Presented at the Association of American Medical Colleges Integrating Quality Meeting: Improving Value through Clinical Transformation, Education and Science, Rosemont, IL, 2014. e-Pub 2014.
- Walls AL, Sahin AA, El-Naggar AK, Middleton LP. Basaloid Salivary-Analogue Tumors of the Mammary Gland: Histopathologic Spectrum and Differential Diagnosis. Presented at the 103rd Annual Meeting of the United States & Canadian Academy of Pathology, San Diego, CA, 2014. e-Pub 2014.
- Karak SG, LP M, Min Y, Hunt KK, Sahin AA. Intraoperative Margin Assessment Significantly Improves Quality of Care in Patients Undergoing Breast Conserving Surgery, 2013. e-Pub 2013.
- Rosen DG, LP M, Yang WT, Sahin AA. Selection of Breast Core Biopsy Specimens for Tissue Bio-Repository. Presented at the U.S. and Canadian Academy of Pathology, San Antonio, TX, 2012. e-Pub 2012.
- Li X, Deavers MT, Guo M, Middleton LP, Liu P, Huo L. The Effect of Prolonged Cold Ischemia Time on Estrogen Receptor Detection in Breast Cancer. Presented at the U.S. and Canadian Academy of Pathology, San Antonio, TX, 2012. e-Pub 2012.
- Khazai L, LP M, Goktepe N, Liu BT, Sahin AA. Breast Pathology Second Review Identifies Clinically Significant Discrepancies in 10% of Cases. Presented at the U.S. and Canadian Academy of Pathology, San Antonio, TX, 2012. e-Pub 2012.
- Rosen D, Quraishi MA, Middleton LP, Yang WT, Sahin AA. Relationship between implementation of the American Society of Clinical Oncology/College of American Pathologists guideline recommendations for breast core-needle biopsies and delay in therapy for patients with breast cancer. ASCO 2011 Breast Cancer Symposium, 2011. e-Pub 2011.
- Nayak A, Gilcrease MZ, Middleton LP, Carkaci S, Zhang J, Sneige N, Huo L. Papillomas on Core Needle Biopsy: Analysis of 88 Cases. Presented at the U.S. and Canadian Academy of Pathology, San Antonio, TX, 2011. e-Pub 2011.
- Richards D, Ayala AG, Middleton LP. Carcinoma In Situ Involving Sclerosing Adenosis: Diagnostic Pearls To Aid the Practicing Pathologist. Presented at the U.S. and Canadian Academy of Pathology, San Antonio, TX, 2011. e-Pub 2011.
- Carkaci S, Adrada B, Middleton LP, Krishnamurthy S, Wei W, Yang WT. Ultrasound Features of Axillary Lymph Node Metastasis in Patients with Invasive Lobular Cancer. Presented at the RSNA 96th Scientific Assembly and Annual Meeting, 2010. e-Pub 2010.
- Middleton LP, Puig P, Jackson S, Kellum L, Burford K, Ninan S, Phipps R, Acosta C, Johnson-Hamilton M, Le NH, Woods J. Process Improvements in Review of Patient’s Pathology Materials Decreases Accessioning Errors. Presented at the CS&E Conference: Building the Bridge at the Quality Chasm, Austin, TX, 2010. e-Pub 2010.
- Middleton LP, Puig P, Hamilton S, Routbort M, Luthra R, Rashid A, Reynolds A, Heydon L, Dunn J, Huimin L, Jackson S, Guerrero J, Lewing C, Bowman C, Ponder J, Cook P, Phipps R, Acosta C, Johnson-Hamilton M, Le NH, Woods J. Pre-analytic Process Improvements for Molecular Testing improves Turn Around time for Results. Presented at the CS&E Conference: Building the Bridge at the Quality Chasm, Austin, TX, 2010. e-Pub 2010.
- Wei B, Tian Z, Tang F, Wei W, Gilcrease MZ, Huo L, Albarracin CT, Resetkova E, Middleton LP, Sahin A, Chen J, Abraham SC, Wu Y. Prognostic Factors of Primary Invasive Mammary Neuroendocrine Carcinoma: Clinicopathologic Analysis of 74 Cases. Presented at the U.S. and Canadian Academy of Pathology, Washington, DC, 2010. e-Pub 2010.
- Perkins GH, Babiera GV, Bedrosian I, Gonzalez-Angulo AM, Whitman GJ, Yang WT, Strom EA, Woodward W, Tereffe W, Yu TK, Oh JL, Buchholz TA, Middleton LP. Mucinous Breast Carcinoma: Occult Multifocality/Multicentricity in a Favorable Disease. Presented at the 32nd Annual San Antonio Breast Cancer symposium, 2009. e-Pub 2009.
- Middleton LP, Price KM, Puig P, Heydon LJ, Tarco E, Sneige N, Barr K, Deavers MT. CS&E Guidelines to Improve Her 2 neu Testing and Interpretation. Presented at the CS&E Conference:Building the Bridge at the Quality Chasm, Austin, TX, 2009. e-Pub 2009.
- Gadre SA, Perkins GH, Sahin AA, Sneige N, Deavers MT, Middleton LP. Neovascularization in Mucinous Ductal Carcinoma In Situ Suggests an Alternative Pathway for Invasion. Presented at the U.S. and Canadian Academy of Pathology Meeting, Boston, MA, 2009. e-Pub 2009.
- Shah S, Middleton LP, Bedrosian I, Giordano SH, Yang W, T-K Y, Woodward W, Oh JL, Tereffe W, Strom EA, Buchholz TA, Perkins GH. Male breast cancer outcomes: validation and modification of a guideline. Presented at the 31st Annual San Antonio Breast Cancer Symposium. San Antonio, TX, 2008. e-Pub 2008.
- Tang F, Gilcrease MZ, Albarracin CT, Huo L, Middleton LP, Resetkova E, Wu Y. Invasive Solid Papillary Carcinoma of the Breast: A Clinicopathologic Analysis of 52 Cases. Presented at the U.S. and Canadian Academy of Pathology Meeting, Denver, CO, 2008. e-Pub 2008.
- Downs-Kelly E, Bell D, Sneige N, Middleton LP. Management of Pleomorphic Lobular Carcinoma In Situ. Presented at the U.S. and Canadian Academy of Pathology Meeting, Denver, CO, 2008. e-Pub 2008.
- Perkins GH, Middleton LP, Tran R, Garcia SM, Cristofanilli M, Pusztai L, Singletary SE, Strom EA, Woodward WA, Yu TK, Oh JL, Tereffe W, Whitman GJ, Huang E, Allen, PK, Buccholz TA. Concurrent chemoradiation with capecitabine achieves meritable response and local control for inoperable and recurrent neoadjuvant chemotherapy refractory breast cancer. Presented at the San Antonio Breast Cancer Symposium. San Antonio, TX, 2007. e-Pub 2007.
- Kelten C, MIttendorf EA, Broglio K, Vo T, Middleton LP, Ueno N, Hunt KK, Sahin AA. Clinical significance of occult axillary lymph node metastses in breast cancer patients without adjuvant systemic therapy: a long term retrospective study. Presented at the San Antonio Breast Cancer Symposium. San Antonio, TX, 2007. e-Pub 2007.
- Nicolas MM, Wu Y, Middleton LP, Gilcrease MZ. Loss of Myoepithelium and Laminin at the Tumor-Stromal Interface in Circumscribed Solid Papillary Carcinoma of the Breast. Presented at the U.S. and Canadian Academy of Pathology Meeting, San Diego, CA, 2007, 2007. e-Pub 2007.
- Middleton LP, Perkins GH, Tucker SL, Sahin AA, Singletary SE. Expression of ERa and ERb in Lobular Carcinoma in Situ. Presented at the U.S. and Canadian Academy of Pathology Meeting, San Diego, CA, 2007, 2007. e-Pub 2007.
- Loya A, Guray M, Hennessy B, Middleton LP, Buchholz T, Valero V, Sahin AA. Detection of Occult Metastatic Carcinoma in Patients Who Had Initial Cytologically Proven Positive Axillary Lymph Nodes with Subsequent Complete Pathologic Response Following Pre-Operative Chemotherapy for Locally Advanced Breast Cancer. An Immunohistochemical Study. Presented at the U.S. and Canadian Academy of Pathology Meeting, Atlanta, GA, 2006, 2006. e-Pub 2006.
- Kim E, Middleton LP, Arun B, Sahin A. Absence of E-cadherin Expression in Invasive Ductal Carcinoma of Breast: A Significant Predictor of Lymph Node Metastasis. Presented at the U.S. and Canadian Academy of Pathology Meeting, Vancouver, British Columbia, 2004. e-Pub 2004.
- Zhang H, Zhai J, Chagpar A, Mirza N, Kuerer HM, Middleton LP, Whitman GJ, Buchholz TA, Hunt KK, Sahin AA. Amount of Tumor Present in Core Needle Biopsy (CNB) Samples: A Significant Predictor of Margin Status in Subsequent Breast-Conserving Surgery (BCS) Specimens in Patients with Ductal Carcinoma In Situ (DCIS). Presented at the U.S. and Canadian Academy of Pathology Meeting, Vancouver, British Columbia, 2004. e-Pub 2004.
- Wang H, Wang H, Middleton LP, Fuller GN, Zhang W, Arun B, Sahin A. The Role of IGFBP2 and IGFBP5 Overexpression in Metastasis of T1 Breast Carcinoma. Presented at the U.S. and Canadian Academy of Pathology Meeting, Vancouver, British Columbia, 2004. e-Pub 2004.
- Giordano SH, Perkins GH, Garcia SM, Middleton LP, Buzdar AU, Hortobagyi GN. Male Breast Cancer: The MD Anderson Experience with Adjuvant Therapy. Presented at the San Antonio Breast Research Meeting, 2003. e-Pub 2003.
- Chagpar A, Mirza AN, Buzdar UA, Dempsey P, Ames FC, Babiera GV, Feig BW, Hunt KK, Kuerer HM, Meric-Bernstam F, Middleton LP, Ross MI, Sahin AA, Singletary SE. Accuracy of Physical Examination (PE), Ultrasonography (US) and Mammography (M) in Predicting Residual Pathological Tumor Size in Patients Treated with Neoadjuvant Chemotherapy (NAC) for Breast Cancer. Presented at the San Antonio Breast Research Meeting, 2003. e-Pub 2003.
- Woodward WA, Huang E, McNeese MD, Perkins GH, Tucker SL, Strom EA, Schechter NR, Middleton LP, Hunt KK, Hortobagyi, GN, Gwyn KM, Buchholz TA. .African American Women with Breast Cancer Have Worse Overall Survival Than Caucasian and Hispanic Women After Mastectomy and Doxorubicin-Based Chemotherapy: Data From Two Independent Data Sets. Presented at the San Antonio Breast Research Meeting, 2003, 2003. e-Pub 2003.
- Cohn M, Middleton LP, Valero V, Sahin A. Gastrointestinal Metastases of Carcinoma of the Breast. Presented at the US and Canadian Academy of Pathology Meeting, Washington, DC, 2003. e-Pub 2003.
- Gokhale S, Albarracin C, Arun B, Middleton LP, Sahin A. Immunohistochemical Expression of Prostate Specific Antigen in Normal Breast Tissue and Breast Neoplasms. Presented at the US and Canadian Academy of Pathology Meeting, Washington, DC, 2003. e-Pub 2003.
- Krishnamurthy S, Sahin A, Middleton LP, Symmans FW, Gilcrease MG, Sneige N, Singletary ES, Kuerer HM, Ross MI, Hunt KK. Intraoperative Imprint Cytology for Evaluation of Axillary Sentinel Lymph Nodes in Breast Cancer. Presented at the US and Canadian Academy of Pathology Meeting, Washington, DC,, 2003. e-Pub 2003.
- Stephens TW, Radaideh MM, Middleton LP, Stelling CB, Whitman GJ. Benign Breast Calcification That Do Not Require Biopsy. Presented at the American Radiology Society Meeting, 2003. e-Pub 2003.
- Goncharuk V, Arun B, Middleton LP, Sahin A. Assessment of Actin-Binding Protein Fascin Expression in Stage I and II Invasive Breast Cancer. A Significant Correlation with Aggressive Clinical Behavior. Presented at the US and Canadian Academy of Pathology Meeting Washington, DC, 2003. e-Pub 2003.
- Chagpar A, Middleton LP, Sahin AA, Ross MI, Ames FC, Feig B, Kuerer HM, Valero V, Hunt KK. Clinical Outcome of Node Negative Breast Cancer Patients with Micrometastic Disease by Immunohistochemistry. Presented at the 2003 American Society of Clinical Oncology Annual Meeting, 2003. e-Pub 2003.
- Gupta D, Perkins GH, Garcia SM, Sahin AA, Middleton LP. Carcinoma of the Male Breast: A Single Institution Clinicopathological Study. Presented at the 2002 ASCP/CAP Annual Meeting, October 2002, Washington DC, 2002. e-Pub 2002.
- Rosenthal SI, Valero V, Fuller GN, Middleton LP, Sahin AA. Chromogenic In Situ Hybridization of Topoisomerase IIa for Evaluation of Locally Advanced Breast Cancer: A Comparative Study of DNA Amplification and Protein Overexpression. Presented at the United States and Canadian Academy of Pathology Meeting, February 2002, Chicago, IL, 2002. e-Pub 2002.
- Rosenthal SI, Valero V, Middleton LP, Strom EA, Guerra LT, Fuller GN, Cohen DS, Sahin AA. Analysis of Topoisomerase IIa Detection Using Chromogenic In-Situ Hybridization and Immunohistochemistry To Predict the Pathologic Response to Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer. Presented at the United States and Canadian Academy of Pathology Meeting, February 2002, Chicago, IL, 2002. e-Pub 2002.
Book Chapters
- Middleton LP. Quality Improvement plan components and Monitors. In: Quality Management in Anatomic Pathology. 1. College of American Pathologists Publications, 37-58, 2017.
- Middleton LP. Tubular, Mucinous, and Medullary Carcinoma. In: Advanced Therapy of Breast Disease. 3rd edition. People's Medical Publishing House USA, 1097-1098, 2012.
- Middleton LP. The Unknown Primary Presenting. In: The Breast: Comprehensive Management of Benign and Malignant Diseases. 4th edition. W.B. Saunders, Chapter 85, 2009.
- Middleton LP. Surgical management of axillary metastases from occult primary breast cancer. In: MD Anderson Cancer Center Surgical Oncology Series, 2006.
- Bedrosian I, Middleton LP. Advanced Therapy of Breast Disease. In: Tubular Mucinous and Medullary Carcinoma, 2003.
- Middleton LP Merino MJ. Head and Neck Surgical Pathology. In: Pathology of the thyroid and parathyroid glands. Lippincott-Williams and Wilkins, 350-388, 2001.
- Middleton LP. Thyroid. In: Multidisciplinary care of head and neck cancer: the MD Anderson approach, 2000.
Letters to the Editor
- Albarracin C, Edgerton ME, Gilcrease MZ, Huo L, Krishnamurthy S, Middleton LP, Resetkova E, Sahin AA, Sneige N, Fraser WS, Wu Y. Is it too soon to start reporting HER2 genetic heterogeneity?. Arch Pathol Lab Med 134: 162-3, 2010.
- Middleton LP, Vlastos G, Mirza NQ, Singletary SE, Sahin AA. Multicentric mammary carcinoma: evidence of monoclonal proliferation. Cancer 94: 1910-1916, 2002.
Patient Reviews
CV information above last modified August 28, 2025