Lesley Flynt, M.D.
Department of Nuclear Medicine, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Nuclear Medicine, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Graduate Medical Education, Site Director, Department of Nuclear Medicine, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
The role of therapy nuclear medicine combined with diagnostic imaging, as applied to the development and application of novel theranostic agents.
The implications of metabolic tumor volume on doubling time and prognosis in patients with solid tumors.
Education & Training
Degree-Granting Education
| 2011 | St. George University, School of Medicine, St. George, GRN, MD, Medical Doctorate |
| 2006 | Harvard University, Cambridge, MA, USA, MA, Molecular Genetics |
| 2002 | California State University, Sacramento, CA, USA, BS, Molecular Biology, Chemistry, Philosophy |
Postgraduate Training
| 2015-2016 | PET/CT Fellowship, Department of Nuclear Medicine and Molecular Imaging, Stanford University Medical Center, Palo Alto, CA |
| 2012-2015 | Nuclear Medicine Resident, Diagnostic Radiology and Molecular Imaging, Beaumont Health System, Royal Oak, MI |
| 2011-2012 | Surgical Intern, Department of Surgery, Drexel University/Hahnemann University Hospital, Philadelphia, PA |
Board Certifications
| 2015 | American Board of Nuclear Medicine |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Toesca DA, Pollom EL, Poullos PD, Flynt L, Cui Y, Quon A, von Eyben R, Koong AC, Chang DT. Assessing local progression after stereotactic body radiation therapy for unresectable pancreatic adenocarcinoma: CT versus PET. Pract Radiat Oncol 7(2):120-125, 2017. e-Pub 2016. PMID: 28274396.
- Flynt L, Grant P, Seitz JP, Qing F. Hepatobiliary Scintigraphy of Evolving Spontaneous Biliary Leak. Clin Nucl Med 40(7):592-5, 2015. PMID: 25899598.
- Bennani-Baiti B, Yadav S, Flynt L, Bennani-Baiti N. Value of positron emission tomography in diagnosing subcutaneous panniculitis-like T-cell lymphoma. J Clin Oncol 33(10):1216-7, 2015. e-Pub 2015. PMID: 25691676.
- Flynt L, Balon HR. 17-year-old runner with shin pain. J Nucl Med Technol 42(3):238-9, 2014. e-Pub 2014. PMID: 24970898.
- Jolepalem P, Flynt L, Rydberg JN, Wong CY. Implications of Ambient Glucose Variation on the Target-to-Background Ratio of Hepatic Tumors By (18)FDG-PET Imaging. J Clin Imaging Sci 4:39, 2014. e-Pub 2014. PMID: 25161808.
- Zhu M, Flynt L, Ghosh S, Mellema M, Banerjee A, Williams E, Panettieri RA, Shore SA. Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells. Am J Respir Cell Mol Biol 45(1):111-9, 2011. e-Pub 2010. PMID: 20870897.
- Johnston RA, Mizgerd JP, Flynt L, Quinton LJ, Williams ES, Shore SA. Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice. Am J Respir Cell Mol Biol 37(4):477-84, 2007. e-Pub 2007. PMID: 17575079.
- Johnston RA, Zhu M, Rivera-Sanchez YM, Lu FL, Theman TA, Flynt L, Shore SA. Allergic airway responses in obese mice. Am J Respir Crit Care Med 176(7):650-8, 2007. e-Pub 2007. PMID: 17641156.
- Shore SA, Terry RD, Flynt L, Xu A, Hug C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118(2):389-95, 2006. e-Pub 2006. PMID: 16890763.
- Lu FL, Johnston RA, Flynt L, Theman TA, Terry RD, Schwartzman IN, Lee A, Shore SA. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol 290(5):L856-65, 2006. e-Pub 2005. PMID: 16373670.
- Faffe DS, Flynt L, Bourgeois K, Panettieri RA, Shore SA. Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: role of vascular endothelial growth factor genotype. Am J Respir Cell Mol Biol 34(2):213-8, 2006. e-Pub 2005. PMID: 16210693.
- Faffe DS, Flynt L, Mellema M, Whitehead TR, Bourgeois K, Panettieri RA, Silverman ES, Shore SA. Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta. Am J Physiol Lung Cell Mol Physiol 288(6):L1040-8, 2005. e-Pub 2005. PMID: 15665043.
- Faffe DS, Flynt L, Mellema M, Moore PE, Silverman ES, Subramaniam V, Jones MR, Mizgerd JP, Whitehead T, Imrich A, Panettieri RA, Shore SA. Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13. J Allergy Clin Immunol 115(3):514-20, 2005. PMID: 15753898.
- Johnston RA, Schwartzman IN, Flynt L, Shore SA. Role of interleukin-6 in murine airway responses to ozone. Am J Physiol Lung Cell Mol Physiol 288(2):L390-7, 2005. e-Pub 2004. PMID: 15516495.
- Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 115(1):103-9, 2005. PMID: 15637554.
- Faffe DS, Whitehead T, Moore PE, Baraldo S, Flynt L, Bourgeois K, Panettieri RA, Shore SA. IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype. Am J Physiol Lung Cell Mol Physiol 285(4):L907-14, 2003. e-Pub 2003. PMID: 12871855.
Abstracts
- Hasanov E, Flynt L, Tidwell RS, Hwang H, Brooks R, King LM, Solley T, Mack D, Yamamura Y, Hayward C, Venkatesan AM, Jonasch E. Phase 1b/2 Study of Combination 177-Lu Girentuximab plus Cabozantinib and Nivolumab in Treatment Naïve Patients with Advanced Clear Cell RCC. ASCO 2023, Chicago, Illinois, 2023.
- Kebbel F, Johnson J, Flynt L, S Lai, M Gule-Monroe. Identification of Primary Site of Malignancy in Squamous Cell Carcinoma of the Head and Neck with Unknown Primary Using F-18 Fluciclovine PET/CT: Preliminary Results of a Pilot Study. American Society of Neuroradiology, 2020.
- Flynt L, Quon A, Alizadeh AA, Kurtz DM. Tumor Lesion Glycolysis as an Indicator of Prognosis in the Pre-treatment Phase of Patients with Diffuse Large B Cell Lymphoma,. Society of Nuclear Medicine and Molecular Imaging Annual Meeting, San Diego, CA,, 2016.
- Flynt L, Graner B, Wong CO, Wu D.. Imaging of Striatal Dopaminergic Neurons using DaTscan in Correlation with Clinical Diagnosis. American Society of Neuroimaging Annual Meeting, Carefree, AZ,, 2015.
- Jolepalem R, Rydberg J, Flynt L, Wong CO.. Mathematical Enhancement for Detecting Liver Metastasis by FDG PET. World Molecular Imaging Congress, Savannah, GA, 2013.
- Flynt L, Faffe DS, Moore PE, Panettieri RA, Shore SA. Effect of B2 Adreno-ceptor Polymorphisms on Inflammatory Gene Expression in Human Airway Smooth Muscle Cells. The International Conference of the American Thoracic Society, San Diego, CA, 2005.
- Flynt L, Whitehead T, Faffe D, Silverman E, Panettieri R, Shore S. Poster presented: Role of MAP Kinases and of NF-kB in TARC Release from Human Airway Smooth Muscle Cells. 100th International Conference of the American Thoracic Society, Orlando, FL, 2004.
Book Chapters
- Flynt L, Kowalsky R., Weatherman K. (Eds.). PET Whole Body Imaging Procedures. In: Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine (4th ed., Ch.32), 2020.
- Flynt L, Kairemo K., Macapinlac H. (Eds.). 18F Sodium Fluoride: Tracer and Technique. In: PET/CT in Clinical Use. Clinicians’ Guides to Radionuclide Hybrid. Springer, 2019.
- Erba PA, Sollini M, Zanca R, Boni R, Flynt L, Lazzeri E, Mariani G, Kuwert T. Hybrid Imaging and Radionuclide Therapy of Musculoskeletal Diseases. In: Nuclear Medicine Textbook. Springer, 571-644, 2019.
Grant & Contract Support
| Title: | Glutamine PET Imaging of Colorectal Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Quantitative PET Imaging of Hepatocellular Carcinoma (HCC) |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Phase 1b/2 study of 177Lu girentuximab plus cabozantinib and nivolumab in treatment naive patients with advanced clear cell RCC |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-Principal Investigator |
Patient Reviews
CV information above last modified July 31, 2024