Linda M. Pak, MD
Department of Breast Surgical Oncology, Division of Surgery
Present Title & Affiliation
Primary Appointment
Assistant Professor, Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2013 | University of Michigan, Ann Arbor, Michigan, US, Medicine, Doctorate of Medicine (MD) |
| 2009 | University of Washington, Seattle, Washington, US, Biology/Physiology, Bachelor of Science (BS) |
Postgraduate Training
| 2021-2022 | Breast Surgical Oncology Fellowship, Memorial Sloan Kettering Cancer Center, New York, New York |
| 2018-2021 | Categorical General Surgery Residency, Brigham and Women’s Hospital / Harvard Medical School, Boston, Massachusetts |
| 2017-2018 | Clinical Research Fellowship, Center for Surgery and Public Health/Harvard Medical School, Boston, Massachusetts |
| 2015-2017 | Clinical Research Fellowship, Memorial Sloan Kettering Cancer Center, New York, New York |
| 2013-2015 | Categorical General Surgery Residency, Barnes-Jewish Hospital / Washington University in St. Louis, St. Louis, Missouri |
Licenses & Certifications
| 2024 | Texas Medical Board |
| 2022 | American Board Of Surgery |
Honors & Awards
| 2023 - 2025 | Shifrin-Meyers Breast Cancer Discovery Fund, NYU (New York University) |
| 2020 - 2021 | Brigham and Women’s Hospital General Surgery Administrative Chief Resident |
| 2020 | Society of Asian Academic Surgeons Resident Development Scholarship |
Professional Memberships
Selected Presentations & Talks
National Presentations
- 2022. How much pain will I have after surgery? A preoperative nomogram to predict pain following mastectomy. Society of Surgical Oncology Annual Meeting, US.
- 2020. Pathologic complete response in HER2-positive breast cancers with radiographically extensive disease. Society of Surgical Oncology Annual Meeting, US.
- 2020. Cancer awareness and stigma in rural Assam India: baseline survey of the Detect Early and Save Her/Him (DESH) program. Society of Surgical Oncology Annual Meeting, US.
- 2018. Further classification for node-positive gastric neuroendocrine neoplasms. Society for Surgery of the Alimentary Tract at Digestive Diseases Week, US.
- 2017. Quantitative imaging features of preoperative CT images predict postoperative hepatic insufficiency: a multi-institutional expansion cohort. American College of Surgeons Clinical Congress. San Diego, California, US.
- 2017. Mutational profiling of resected intrahepatic cholangiocarcinomas. 2017 American Society of Clinical Oncology (ASCO) Annual Meeting, US.
- 2017. Clinical utility of immunoglobulin-G4 in the diagnosis of autoimmune pancreatitis. Americas Hepato-Pancreato-Biliary Association 2017 Annual Meeting. Miami, Florida, US.
- 2016. Prospective Phase II trial of combination hepatic artery and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential. American College of Surgeons Clinical Congress, US.
- 2016. Natural history of patients followed radiographically with mucinous cystic neoplasms of the pancreas. Society for Surgery of the Alimentary Tract at Digestive Diseases Week. San Diego, California, US.
International Presentations
- 2018. Utility of image guidance in the localization of disappearing colorectal liver metastases. 13th International Hepato-Pancreato-Biliary Association (IHPBA) World Congress, CH.
Selected Publications
Peer-Reviewed Articles
- Pak, LM, Matar-Ujvary, R, Verdial, FC, Haglich, KA, Sevilimedu, V, Nelson, JA, Gemignani, ML. Long-Term Patient-Reported Outcomes Comparing Oncoplastic Breast Surgery and Conventional Breast-Conserving Surgery. Ann Surg Oncol 30(12):7091-7098, 2023. e-Pub 2023. PMID: 37556008.
- Miah, PA, Pourkey, N, Marmer, A, Sevdalis, A, Fiedler, L, DiMaggio, C, Pak, LM, Shapiro, RL, Hiotis, K, Axelrod, D, Guth, A, Schnabel, FR. Results of Magnetic Resonance Imaging (MRI) Screening in Patients at High Risk for Breast Cancer. Ann Surg Oncol 30(10):6275-6280, 2023. e-Pub 2023. PMID: 37561341.
- Keng KG, Witowski J, Gv KK, Yeung F, Kim M, Kim J, Pleasure M, Moczulski C, Lopez LJL, Zhang H, Harbi MA, Shamout FE, Major VJ, Heacock L, Moy L, Schnabel F, Pak LM, Shen Y, Geras KJ. Improving information extraction from pathology reports using named entity recognition. Res Sq, 2023.
- Midya, A, Chakraborty, J, Srouji, R, Narayan, RR, Boerner, T, Zheng, J, Pak, LM, Creasy, JM, Escobar, LA, Harrington, KA, Gönen, M, D'Angelica, M, Kingham, TP, Do, RK, Jarnagin, W, Simpson, A. Computerized Diagnosis of Liver Tumors From CT Scans Using a Deep Neural Network Approach. IEEE J Biomed Health Inform 27(5):2456-2464, 2023. e-Pub 2023. PMID: 37027632.
- Pak, LM, Pawloski, KR, Sevilimedu, V, Kalvin, HL, Le, T, Tokita, HK, Tadros, AB, Morrow, M, VanZee, K, Kirstein, L, Moo, TA. How Much Pain Will I Have After Surgery? A Preoperative Nomogram to Predict Acute Pain Following Mastectomy. Ann Surg Oncol 29(11):6706-6713, 2022. e-Pub 2022. PMID: 35699814.
- Jolissaint, JS, Wang, T, Soares, KC, Chou, JF, Gönen, M, Pak, LM, Boerner, T, Do, RK, Balachandran, VP, D'Angelica, M, Drebin, JA, Kingham, TP, Wei, AC, Jarnagin, W, Chakraborty, J. Machine learning radiomics can predict early liver recurrence after resection of intrahepatic cholangiocarcinoma. HPB 24(8):1341-1350, 2022. e-Pub 2022. PMID: 35283010.
- Kim, HJ, Dominici, LS, Rosenberg, S, Zheng, Y, Pak, LM, Poorvu, PD, Ruddy, KJ, Tamimi, RM, Schapira, L, Come, S, Peppercorn, J, Borges, VF, Warner, E, Vardeh, H, Collins, LC, Gaither, R, King, TA, Partridge, AH. Surgical Treatment After Neoadjuvant Systemic Therapy in Young Women With Breast Cancer. Annals of Surgery 276(1):173-179, 2022. e-Pub 2022. PMID: 33378304.
- Yang, T, Fong, ZV, Pak, LM, Wang, SJ, Wei, J, Wang, J. A Modified T-stage Classification for Gastric Neuroendocrine Tumors. J Surg Res 270:486-494, 2022. e-Pub 2022. PMID: 34800795.
- Pak LM, Purand CC, Nadipally S, Rao MP, Mukherjee S, Hedge SKB, Golshan M. Cancer awareness and stigma in rural Assam India: baseline survey of the Detect Early and Save Her/Him (DESH) program. Ann Surg Oncol 28(12):7006-7013, 2021. e-Pub 2021.
- Boerner T, Pak LM, Doussot A, Drill E, Goldman DA, Gonen M, Allen PJ, Balachandran VP, Cercek A, Harding J, Solid D, D'Angelica MI, DeMatteo RP, Drebin J, Kemeny NE, Kingham TP, Simpson AL, Hecktman JF, Vakiani E, Sigel CS, Lowery MA, Ijermans J, Buttner S, Koerkamp BG, Doukas M, Jarnagin WR. Genetic determinants of outcome in intrahepatic cholangiocarcinoma. Hepatology 74(3):1429-1444, 2021. e-Pub 2021.
- Pak LM, Rosenberg SM, Ruddy KJ, Tamimi RM, Peppercorn J, Schapira L, Borges VF, Come SE, Warner E, Snow C, Collin L, King TA, Partridge AH. Tumor phenotype and concordance in synchronous bilateral breast cancer in young women. Breast Cancer Res Treat 186(3):815-821, 2021. e-Pub 2021.
- Pak LM, Banaag A, Koehlmoos TP, Haider AH, Learn PA. Non-clinical drivers of variation in preoperative MRI utilization for breast cancer. Ann Surg Oncol 27(9):3414-3423, 2020. e-Pub 2020.
- Chawla A, Molina G, Pak LM, Rosenthal M, Mancias JD, Clancy T, Wolpin BM, Wang J. Neoadjuvant treatment is associated with improved survival in borderline resectable pancreatic cancer. Ann Surg Oncol 27(4):1191-1200, 2020. e-Pub 2020.
- Pak LM, Kwon NK, Baldini EH, Learn PA, Koehlmoos T, Haider AH, Raut CP. Racial differences in the treatment of extremity soft-tissue sarcoma in a universally-insured population. J Surg Res 250:125-134, 2020. e-Pub 2020.
- Li GZ, Tio MC, Pak LM, Krier J, Seifter JL, Tullius SG, Riella LV, Malek SK, Stergachis A. Non-cirrhotic hyperammonemia after deceased donor kidney transplantation: a case report. Am J Transplant 19(11):3197-3201, 2019. e-Pub 2019.
- Mahvi DA, Pak LM, Fields AC, Urman RD, Gold JS, Whang EE. Prediction of discharge destination following major hepatectomy. HPB 21(11):1462-1469, 2019. e-Pub 2019.
- Wang T, Drill E, Vakiani E, Pak LM, Boerner T, Askan G, Schvartzman JM, Simpson AL, Jarnagin WR, Sigel CS. Distinct histological features are associated with IDH1 mutation in intrahepatic cholangiocarcinoma. Hum Pathol 91:19-25, 2019. e-Pub 2019.
- Pak LM, Mahvi DA, Urman RD, Gold JS, Whang EE. Discharge destination following pancreaticoduodenectomy: a NSQIP analysis of predictive factors and post-discharge outcome. Am J Surg 218(2):342-348, 2019. e-Pub 2019.
- Pak LM, Yang T, Wang J. The safety and efficacy of gastrectomy for gastric cancer among octogenarians: a Western population-based study. J of Geriatr Oncol 10(4):598-603, 2019. e-Pub 2019.
- Fields AC, McCarty JC, Lu P, Vierra BM, Pak LM, Irani J, Goldberg JE, Bleday R, Chan J, Melnitchouk N. Colon neuroendocrine tumors: a new lymph node staging classification. Ann Surg Oncol 26(7):2028-2036, 2019. e-Pub 2019.
- Pak LM, Mahvi DA, Bose SK, Urman RD, Gold JS, Whang EE. Fast-tract pancreaticoduodenectomy: factors associated with early discharge. World J Surgery 43(5):1332-1341, 2019. e-Pub 2019.
- Pak LM, Yang T, Wang J. Further classification for node-positive gastric neuroendocrine neoplasms. J of Gastrointest Surg 23(4):720-729, 2019. e-Pub 2019.
- Pak LM, Gagniere J, Allen PJ, Balachandran VP, D'Angelica MI, DeMatteo RP, Jarnagin WR, Simpson AL. Utility of image guidance in the localization of disappearing colorectal liver metastases. J Gastrointest Surg 23(4):760-767, 2019. e-Pub 2019.
- Fields AC, McCarty JC, Pak LM, Lu P, Irani J, Goldberg JE, Bleday R, Chan J, Melnitchouk N. New lymph node staging for rectal neuroendocrine tumors. J Surg Oncol 119(1):156-162, 2019. e-Pub 2019.
- Aherne EA, Pak LM, Goldman DA, Gonen M, Jarnagin WR, Simpson AL, Do RKG. Intrahepatic cholangiocarcinoma: can imaging phenotypes predict survival and tumor genetics?. Abdom Radiol (NY) 43(10):2665-2672, 2018. e-Pub 2018.
- Sigel CS, Zhou Y, Basturk O, Drill E, Askan G, Pak LM, Vakiani E, Boerner T, Simpson AL, Jarnagin WR, Do RKG, Klimstra DS. Intrahepatic cholangiocarcinomas have histologically and immunophenotypically distinct small and large duct patterns. Am J Surg Pathol, 2018. e-Pub 2018.
- Changoor NR, Pak LM, Nguyen LL, Bleday R, Trinh QD, Koehlmoos T, Learn PA, Haider AH, Goldberg JE. The effect of an equal access military health system on racial disparities in colorectal cancer screening. Cancer 124(18):3724-3732, 2018. e-Pub 2018.
- Pak LM, Gonen M, Seier K, Allen PJ, Balachandran VP, D'Angelica MI, Jarnagin WR, Kingham TP, Do RKG, Simpson AL. Can Physician Gestalt Predict Survival in Patients with Resectable Pancreatic Adenocarcinoma?. Abdom Radiol (NY) 43(8):2113-2118, 2018. e-Pub 2018.
- Pak LM, Chaudhary M, Lange JK, Blucher JA, Barton LB, Sturgeon D, Koehlmoos T, Haider AH, Schoenfeld AJ. Does orthopedic outpatient care reduce emergency department utilization following total joint arthroplasty?. Clin Orthop Relat Res 476:1655-1662, 2018. e-Pub 2018.
- Pak LM, Fogel HA, Chaudhary MA, Kwon NK, Barton LB, Koehlmoos T, Haider AH, Schoenfeld AJ. Outpatient spine clinic utilization is associated with reduced emergency department visits following spine surgery. Spine (Phila Pa 1976) 43(14):E836-E841, 2018. e-Pub 2018.
- Pak LM, Charkraborty J, Gonen M, Allen PJ, Balachandran VP, Chapman WC, D'Angelica MD, DeMatto RP, Do RKG, Kingham TP, Koerkamp BG, Lee SY, Massani M, Van De Stok EP, Jarnagin WR, Simpson AL. Quantitative imaging features of preoperative CT images predict postoperative hepatic insufficiency: a multi-institutional expansion cohort. J Am Coll Surg 226(5):835-843, 2018. e-Pub 2018.
- Pak LM, Kemeny NE, Capanu M, Chou J, Boucher T, Cercek A, Balachandran VP, Kingham TP, Allen PJ, DeMatteo RP, Jarnagin WR, D'Angelica MI. Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: long term results and curative potential. J Surg Onc 117(4):634-643, 2018. e-Pub 2018.
- Kingham TP, Pak LM, Simpson AL, Leung U, Doussot A, D'Angelica MI, DeMatteo RP, Allen PJ, Jarnagin WR. 3D image guidance identifies colorectal cancer liver metastases not seen on intraoperative ultrasound: results from a Phase II trial. HPB 20(3):260-267, 2018. e-Pub 2018.
- Pak LM, Scattner MA, Balachandran VP, D'Angelica MI, DeMatteo RP, Kingham TP, Jarangin WR, Allen PJ. The clinical utility of immunoglobulin G4 in the evaluation of autoimmune pancreatitis and pancreatic adenocarcinoma. HPB 20(2):182-187, 2018. e-Pub 2018.
- Horvat N, Nikolovski I, Long N, Gerst S, Zheng J, Pak LM, Simpson A, Zheng J, Capanu M, Jarnagin WR, Mannelli L, Do RKG. Imaging features of hepatocellular carcinoma compared to intrahepatic cholangiocarcinoma and combined tumor on MRI using liver imaging and data system (LI-RADS) version 2014. Abdom Radiol (NY) 43(1):169-178, 2018. e-Pub 2018.
- Zheng J, Chakraborty J, Chapman WC, Gerst S, Gonen M, Pak LM, Jarnagin WR, DeMatteo RP, Do RK, Simpson AL. Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma Using Quantitative CT Image Analysis. J Am Coll Surg 225(6):778-788, 2017. e-Pub 2017.
- Zheng J, Glezerman IG, Sadot E, McNeil A, Zamara C, Gonen M, Creasy J, Pak LM, Balachandran VP, D'Angelica MI, Allen PJ, DeMatteo RP, Kingham TP, Jarnagin WR, Jaimes EA. Hypophosphatemia Following Hepatectomy or Pancreatectomy: Role of the Phosphaturic Factor Nicotinamide Phosphoribosyltransferase. J Am Coll Surg 225(4):488-497, 2017. e-Pub 2017.
- Pak LM, D'Angelica MI, DeMatteo RP, Kingham TP, Balachandran VP, Jarnagin WR, Allen PJ. Natural history of patients followed radiographically with mucinous cysts of the pancreas. J Gastrointest Surg 21(10):1599-1605, 2017. e-Pub 2017.
- Pak LM, Coit DG, Eaton AA, Allen PJ, D'Angelica MI, DeMatteo RP, Jarnagin WR, Strong VE, Kingham TP. Percutaneous peritoneal lavage for the rapid staging of gastric and pancreatic cancer. Ann Surg Oncol 24(5):1174-1179, 2017. e-Pub 2017.
- Ma L, Dominguez-Rosado I, Gennarelli RL, Bach PB, Gonen M, D'Angelica MI, DeMatteo RP, Kingham TP, Brennan MF, Jarnagin WR, Allen PJ. The cost of postoperative pancreatic fistula vs. the cost of pasireotide: Results from a prospective randomized trial. Ann Surg 265(1):11-16, 2017. e-Pub 2017.
- Ma L, Levi B, Oppenheimer AJ, Kasten SJ. Intralesional laser therapy for vascular malformations. Ann Plast Surg 73(5):547-551, 2014. e-Pub 2014.
- Parenteau CS, Ehrlich P, Ma L, Su GL, Holcombe S, Wang SC. The quantification of liver anatomical changes and assessment of occupant liver injury patterns. Stapp Car Crash J 57:267-283, 2013. e-Pub 2013.
- Kothari V, Wei I, Shankar S, Kalyana- Sundaram S, Wang L, Ma L, Vats P, Grasso CS, Robinson DR, Wu YM, Cao X, Simeone DM, Chinnaiyan AM, Kumar-Sinha C. Outlier kinase expression by RNA sequencing as targets for precision therapy. Cancer Discov 3(3):280-293, 2013. e-Pub 2013.
Review Articles
- Pak, LM, Morrow, M. Addressing the problem of overtreatment in breast cancer. Expert Rev Anticancer Ther 22(5):535-548, 2022. e-Pub 2022. PMID: 35588396.
Patient Reviews
CV information above last modified July 22, 2026