Liyong Zeng, PHD
Department of Experimental Therapeutics, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Instructor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Dual/Joint/Adjunct Appointment
Instructor, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2015 | Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, CN, Cell Biology, PhD |
| 2008 | Sichuan University, Chengdu, CN, Biological Science, Bachelor |
Postgraduate Training
| 2022-2024 | Research Investigator, University of Texas MD Anderson Cancer Center, Houston, TX |
| 2016-2022 | Postdoctoral fellow, University of Texas MD Anderson Cancer Center, Houston, TX |
Selected Publications
Peer-Reviewed Articles
- Zeng L. Selective NSD2 Inhibition Reveals an Epigenetic Dependency of KRAS-Driven Cancers. Nature. e-Pub 2024.
- Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Lyu R, Caporicci M, Morales Benitez A, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko Ł, Li W, Mazur PK, Gozani O.. NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis. Mol Cell 81(21):4481–4492, 2021. e-Pub 2021. PMID: 34555356.
- Hang Q, Zeng L, Wang L, Nie L, Yao F, Teng H, Deng Y, Yap S, Sun Y, Frank SJ, Chen J, Ma L.. Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. Nat Commun 12(1):4033, 2021. e-Pub 2021. PMID: 34188037.
- Xiao Z, Chang L, Kim J, Zhang P, Hang Q, Yap S, Guo Y, Zhou Z, Zeng L, Hu X, Siverly A, Sun Y, Ma L.. USP37 is a SNAI1 deubiquitinase. Am J Cancer Res 9(12):2749-2759, 2019. e-Pub 2019. PMID: 31911859.
- Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L.. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun 9(1):2269, 2018. e-Pub 2018. PMID: 29891922.
- Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L.. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Rep 23(3):823-837, 2018. e-Pub 2018. PMID: 29669287.
- Zhou Z, Zhang P, Hu X, Kim J, Yao F, Xiao Z, Zeng L, Chang L, Sun Y, Ma L.. USP51 promotes deubiquitination and stabilization of ZEB1. Am J Cancer Res 7(10):2020-2031, 2017. e-Pub 2017. PMID: 29119051.
- Zeng L, Cai C, Li S, Wang W, Li Y, Chen J, Zhu X, Zeng YA.. Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells. PLoS Genet 12(5):e1006055, 2016. e-Pub 2016. PMID: 27203244.
- Zi Z, Zhang Z, Li Q, An W, Zeng L, Gao D, Yang Y, Zhu X, Zeng R, Shum WW, Wu J.. CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse. PLoS Genet 11(8):e1005485, 2015. e-Pub 2015. PMID: 26305884.
- An W, Zhang Z, Zeng L, Yang Y, Zhu X, Wu J.. Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production. PLoS One 10(7):e0132721, 2015. e-Pub 2015. PMID: 26161966.
- Li S, Song W, Jiang M, Zeng L, Zhu X, Chen J.. Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Lett 588(11):1989-96, 2014. e-Pub 2014. PMID: 24794231.
- Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H, Zhu X.. The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem 288(42):30087-30093, 2013. e-Pub 2013. PMID: 24003236.
- Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X.. Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res 22(7):1140-54, 2012. e-Pub 2012. PMID: 22430153.
Patient Reviews
CV information above last modified April 17, 2025