Marie-Claude C Hofmann, Ph.D.
Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Professor, Department of Endocrine Neoplasia and Hormonal Disorders - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Regulation of signaling pathways within the stem cell niche Role of NOTCH signaling and its interactions with FGF2 and TGFβ pathways Effects of environmental toxicants on the germ line and the behavior of thyroid cancer cells Effects of targeted therapies on male fertility Mechanisms of acquired resistance to tyrosine kinase inhibitors
Education & Training
Degree-Granting Education
| 1988 | Dept. of Oncology University Hospital Zürich, Dept. of Biology University of Lausanne, Lausanne, CHE, PHD, Cell Biology, Cancer Research |
| 1977 | Dept. of Biology University of Lausanne, Lausanne, CHE, BS, Biological Sciences |
Postgraduate Training
| 1989-1995 | Postdoctoral Fellowship, Developmental and Reproductive Biolog, Sanford-Burnham Medical Research Institute, La Jolla, CA |
Honors & Awards
| 2011 | Killam Visiting Research Scholar Award, University of Calgary, AB, Canada |
| 2010 | Member, NIH CSR-CMIR study section, NIH, CSR |
| 2010 | Dr. Gordon and Mrs. Helen Kruger Research Excellence Award, College of Veterinary Medicine, University of Illinois at Urbana-Champaign |
| 2007 | NIH Independent Scientist Award (K02 HD054607), NIH, NICHD |
| 2005 | George E. Nolan Award for Excellence in Research, University of Dayton, OH |
| 1993 | National Research Service Award, National Cancer Institute, USA, NIH, NCI |
Selected Publications
Peer-Reviewed Articles
- Iyer PC, Cote GJ, Hai T, Gule-Monroe M, Bui JH, Williams MD, Hess KN, Hofmann MC, Dadu R, Zafereo M, Busaidy NL, Ferrarotto, Subbiah V, Gross N, Gunn BG, Skinner HD, Garden AS, Cabanillas ME. Circulating BRAF V600E cell free DNA (cfDNA) as a biomarker in the management of Anaplastic Thyroid Carcinoma. JCO Precision Oncology 2:1-11, 2018.
- Puli OR, Danysh BP, McBeath E, Sinha DK, Hoang NM, Powell RT, Danysh HE, Cabanillas ME, Cote GJ, Hofmann MC. The transcription factor ETV5 mediates BRAFV600E-induced proliferation and TWIST1 expression in papillary thyroid cancer cells. Neoplasia 20(11):1121-1134, 2018. e-Pub 2018. PMID: 30265861.
- Paez-Mayorga J, Kotla S,Tao Y, Giancursio C, Danysh BP, Hofmann MC and Le NT. Ponatinib activates an inflammatory response in endothelial cells via ERK5 SUMOylation. Front. Cardiovasc. Med 5:125, 2018. PMID: 30238007.
- Cabanillas ME, Ferrarotto R, Garden AS, Ahmed S, Busaidy NL, Dadu R, Williams MD, Skinner H, Gunn GB, Grosu H, Iyer P, Hofmann MC, Zafereo M. Neoadjuvant BRAF- and immune-directed therapy for anaplastic thyroid carcinoma. Thyroid 28(7):945-951, 2018. e-Pub 2018. PMID: 29742974.
- Beadnell TC, Wuensch KE, Clark EG, Danysh BP, Hofmann MC, Pozdeyev N, Schweppe RE. Src Mediated Regulation of the PI3K Pathway in Advanced Papillary and Anaplastic Thyroid Cancer. Oncogenesis 17(2):23-36, 2018. PMID: 29487290.
- Garcia TX, Parekh P, Gandhi P, Sinha K and Hofmann MC. The NOTCH ligand JAG1 regulates GDNF expression in Sertoli cells. Stem Cells & Development 26(8):585-598, 2017. PMID: 28051360.
- Liang S, Yin L, Shengyang Yu K, Hofmann MC, and Yu X. High-Content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells. Toxicol Sci 155(1):43-60, 2017. PMID: 27633978.
- Franca LR, Hess RA, Dufour JM, Hofmann MC, Griswold MD. The Sertoli cell: one hundred fifty years of beauty and plasticity. Andrology 4(2):189-212, 2016.
- Danysh BP, Rieger E, Sinha D, Cabanillas M, Cote G and Hofmann MC. Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model. Oncotarget 7(21):30907-30923, 2016. e-Pub 2016. PMID: 27127178.
- Garcia TX and Hofmann MC. Regulation of germ line stem cell homeostasis. Animal Reproduction 12(1):35-45, 2015.
- Phan LM, Fuentes-Mattei E, Wu W, Velazquez-Torres V, Sircar K, Wood CG, Hai T, Jimenez C, Cote GJ, Hofmann MC, Verhaak R, Pagliaro L, Lee MH, Yeung SCJ, and Habra MA. Hepatocyte growth factor/cMET pathway activation enhances cancer hallmarks in adrenocortical carcinoma: a potential therapeutic target. Cancer Research 75(19):4131-4142, 2015. PMID: 26282167.
- Cote GJ, Grubbs EG, Hofmann MC. Thyroid C-Cell biology and Oncogenic Transformation. Recent Results Cancer Res 204:1-39, 2015. PMID: 26494382.
- Garcia TX, Farmaha JK, Kow S and Hofmann MC. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development 141(23):4468-4478, 2014. PMID: 25406395.
- Garcia TX, Costa GM, Franca LR, Hofmann MC. Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels. Reprod Toxicol 45(6):59-70, 2014. e-Pub 2014. PMID: 24447867.
- Gabrielson NP, Desai AV, Mahadik B, Hofmann MC, Kenis PJ, Harley BA. Cell-Laden Hydrogels in Integrated Microfluidic Devices for Long-Term Cell Culture and Tubulogenesis Assays. Small 9(18):3076-81, 2013. e-Pub 2013. PMID: 23468408.
- Garcia TX, Hofmann MC. NOTCH signaling in Sertoli cells regulates gonocyte fate. Cell Cycle 12(16):2538-45, 2013. e-Pub 2013. PMID: 23907117.
- Garcia TX, DeFalco T, Capel B, Hofmann MC. Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. Dev Biol 377(1):188-201, 2013. e-Pub 2013. PMID: 23391689.
- Ayala-Ramirez M, Palmer JL, Hofmann MC, de la Cruz M, Moon BS, Waguespack SG, Habra MA, Jimenez C. Bone Metastases and Skeletal Related Events in Patients with Malignant Pheochromocytoma and Sympathetic Paraganglioma. J Clin Endocrinol Metab 98(4):1492-7, 2013. e-Pub 2013. PMID: 23436918.
- Lucas BE, Fields C, Joshi N, Hofmann MC. Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia. Toxicology 299(1):10-9, 2012. e-Pub 2012. PMID: 22564763.
- Garcia T, Hofmann MC. Isolation of undifferentiated and early differentiating type A spermatogonia from Pou5f1-GFP reporter mice. Methods Mol Biol 825:31-44, 2012. PMID: 22144234.
- Campos-Junior PH, Costa GM, Lacerda SM, Rezende-Neto JV, de Paula AM, Hofmann MC, de França LR. The spermatogonial stem cell niche in the collared peccary (Tayassu tajacu). Biol Reprod 86(5):155, 1-10, 2012. e-Pub 2012. PMID: 22262689.
- Costa GM, Avelar GF, Rezende-Neto JV, Campos-Junior PH, Lacerda SM, Andrade BS, Thomé RG, Hofmann MC, Franca LR. Spermatogonial stem cell markers and niche in equids. PLoS One 7(8):e44091, 2012. e-Pub 2012. PMID: 22937157.
- Waheeb R, Hofmann MC. Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. Int J Androl 34(4 Pt 2):e296-305; discussion e305, 2011. PMID: 21790653.
- Simon L, Ekman GC, Garcia T, Carnes K, Zhang Z, Murphy T, Murphy KM, Hess RA, Cooke PS, Hofmann MC. ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells 28(10):1882-92, 2010. PMID: 20799334.
- Braydich-Stolle LK, Lucas B, Schrand A, Murdock RC, Lee T, Schlager JJ, Hussain SM, Hofmann MC. Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. Toxicol Sci 116(2):577-89, 2010. e-Pub 2010. PMID: 20488942.
- Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M. Age affects gene expression in mouse spermatogonial stem/progenitor cells. Reproduction 139(6):1011-20, 2010. e-Pub 2010. PMID: 20371641.
- Morrow CM, Tyagi G, Simon L, Carnes K, Murphy KM, Cooke PS, Hofmann MC, Hess RA. Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod 81(5):871-9, 2009. e-Pub 2009. PMID: 19571261.
- Tyagi G, Carnes K, Morrow C, Kostereva NV, Ekman GC, Meling DD, Hostetler C, Griswold M, Murphy KM, Hess RA, Hofmann MC, Cooke PS. Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis. Biol Reprod 81(2):258-66, 2009. e-Pub 2009. PMID: 19369650.
- Simon L, Ekman GC, Kostereva N, Zhang Z, Hess RA, Hofmann MC, Cooke PS. Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers. Stem Cells 27(7):1666-75, 2009. PMID: 19544441.
- Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M. The molecular signature of spermatogonial stem/progenitor cells in the 6-day-old mouse testis. Biol Reprod 80(4):707-17, 2009. e-Pub 2008. PMID: 19109221.
- Lucas B, Fields C, Hofmann MC. Signaling pathways in spermatogonial stem cells and their disruption by toxicants. Birth Defects Res C Embryo Today 87(1):35-42, 2009. PMID: 19306349.
- Chu C, Schmidt JJ, Carnes K, Zhang Z, Kong HJ, Hofmann MC. Three-dimensional synthetic niche components to control germ cell proliferation. Tissue Eng Part A 15(2):255-62, 2009. PMID: 18816170.
- Liu CF, Barsoum I, Gupta R, Hofmann MC, Yao HH. Stem cell potential of the mammalian gonad. Front Biosci (Elite Ed) 1:510-8, 2009. e-Pub 2009. PMID: 19482665.
- Kostereva N, Hofmann MC. Regulation of the spermatogonial stem cell niche. Reprod Domest Anim 43 Suppl 2:386-92, 2008. PMID: 18638151.
- Hofmann MC. Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol 288(1-2):95-103, 2008. e-Pub 2008. PMID: 18485583.
- Schlesser HN, Simon L, Hofmann MC, Murphy KM, Murphy T, Hess RA, Cooke PS. Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice. Biol Reprod 78(3):483-9, 2008. e-Pub 2007. PMID: 18032421.
- He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells 26(1):266-78, 2008. e-Pub 2007. PMID: 17962702.
- Morrow CM, Hostetler CE, Griswold MD, Hofmann MC, Murphy KM, Cooke PS, Hess RA. ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege. Ann N Y Acad Sci 1120:144-51, 2007. e-Pub 2007. PMID: 17911411.
- He Z, Jiang J, Hofmann MC, Dym M. Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase. Biol Reprod 77(4):723-33, 2007. e-Pub 2007. PMID: 17625109.
- Braydich-Stolle L, Kostereva N, Dym M, Hofmann MC. Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Dev Biol 304(1):34-45, 2007. e-Pub 2006. PMID: 17222400.
- Hess RA, Cooke PS, Hofmann MC, Murphy KM. Mechanistic insights into the regulation of the spermatogonial stem cell niche. Cell Cycle 5(11):1164-70, 2006. e-Pub 2006. PMID: 16721062.
- Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88(2):412-9, 2005. e-Pub 2005. PMID: 16014736.
- Braydich-Stolle L, Nolan C, Dym M, Hofmann MC. Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate. Ann N Y Acad Sci 1061:94-9, 2005. PMID: 16467260.
- Chen C, Ouyang W, Grigura V, Zhou Q, Carnes K, Lim H, Zhao GQ, Arber S, Kurpios N, Murphy TL, Cheng AM, Hassell JA, Chandrashekar V, Hofmann MC, Hess RA, Murphy KM. ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature 436(7053):1030-4, 2005. PMID: 16107850.
- Hofmann MC, Braydich-Stolle L, Dym M. Isolation of male germ-line stem cells; influence of GDNF. Dev Biol 279(1):114-24, 2005. PMID: 15708562.
- Hofmann MC, Braydich-Stolle L, Dettin L, Johnson E, Dym M. Immortalization of mouse germ line stem cells. Stem Cells 23(2):200-10, 2005. PMID: 15671143.
Book Chapters
- Cabanillas ME, Schweppe RE, Dadu R, Cote GJ, Beadnell TC, Hofmann MC. Section IX. Future Developments and Directions for Research in Thyroid Cancer, Chapter 25. Translational research and genomics driven trials in thyroid cancer. In: Practical Management of Thyroid Cancer: A Multidisciplinary Approach. 2. Springer: New York, 319-338, 2017.
- Cote G, Bagheri-Yarmand R, Hofmann MC and Gagel RF.. Molecular Mechanisms: The RET Proto-Oncogene. In: Medullary Thyroid Cancer. Springer International Publishing: Switzerland, 47-63, 2016.
- Hofmann MC. Stem Cells and Nanomaterials. In: Nanomaterial (Adv Exp Med Biol). Springer: New York, 255-275, 2014.
- Simon L, Hofmann MC, Cooke P. Spermatogonial stem cells-an alternative of pluripotent stem cells for regenerative medicine. In: Tissue Regeneration. In Tech: Rijeka, Croatia, 2011.
Patient Reviews
CV information above last modified April 23, 2024