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      Mary Guirguis Image

      Mary Guirguis, M.D.

      Department of Breast Imaging, Division of Diagnostic Imaging

      About Dr. Mary Guirguis

      Dr. Guirguis is a faculty member in the department of breast imaging. She is passionate about clinical service and trainee education. Her clinical and research interests include breast conservation therapy, triple negative breast cancer, preoperative localization, digital breast tomosynthesis, and breast MRI.
      Read More

      Present Title & Affiliation

      Primary Appointment

      Associate Professor, Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

      Research Interests

      Breast Conservation Therapy

      Preoperative Localization

      Triple Negative Breast Cancer

      Breast MRI

      Clinical Interests

      Resident and fellow education

      Digital Breast Tomosynthesis

      Preoperative localization

      Education & Training

      Degree-Granting Education

      2013The University of Texas Medical School at Houston (McGovern Medical School), Houston, TX, US, MD
      2009University of Houston, Houston, TX, US, German, BA
      2009University of Houston, Houston, TX, US, Biology, BS

      Postgraduate Training

      2018-2019Clinical Fellowship, Breast and Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
      2017-2017Healthcare Management Certificate, University of Houston Clear Lake, Houston, TX
      2014-2018Clinical Residency, Diagnostic Radiology, The University of Texas Medical School at Houston (McGovern Medical School), Houston, TX
      2013-2014Clinical Internship, Internal Medicine, Presbyterian Hospital Dallas, Dallas, TX

      Licenses & Certifications

      2019American Board of Radiology (MOC)
      2017Texas Medical Board Physician's Permit

      Experience & Service

      Editorial Activities

      Assistant Editor, Journal of Computer Assisted Tomography, 2026 - Present

      CME Consulting Editor, American Journal of Roentgenology, 2021 - 2023

      Selected Publications

      Peer-Reviewed Articles

      1. Delgado L, Dhamnbe S, Resetkova E, Guirguis MS, Puvvala A, Bevers TB, Huo L, Wanis KN. Risk of malignancy after diagnosis of radial sclerosing lesion without atypia. Breast Cancer Research and Treatment, 2026. e-Pub 2026. PMID: 42257745.
      2. Huo, X, Moseley, T, Adrada, BE, Yam, C, Huo, L, Guirguis, MS, Patel, MM, Leung, J, Whitman, GJ, Candelaria, RP, Lane, DL, Yang, WT, Sun, J, Litton, J, Valero, V, Arun, BK, Hwang, K, Wei, P, Ma, J, Rauch, GM. DCE-MRI for assessment of pathologic complete response after completion of neoadjuvant therapy in triple-negative breast cancer patients. Journal of Clinical Oncology 44:611, 2026. e-Pub 2026.
      3. Tenreiro, A, Sun, J, Whitman, GJ, Dinh, A, Kai, M, Lu, Y, Saleem, S, Guirguis, MS, Patel, MM, Lucci, A, Woodward, W, Le-Petross, H. Locoregional Nodal Status at Initial Presentation on Ultrasound (US) and Positron Emission Tomography/Computerized Tomography (18F-FDG PET/CT) in Inflammatory Breast Cancer (IBC) Patients is Predictive of Overall Survival. Clinical breast cancer 26(4):109-118, 2026. e-Pub 2026. PMID: 41895005.
      4. Adrada, BE, Guirguis, MS, Huo, L, Yam, C, Tripathy, D, Candelaria, RP, Yang, W, Patel, MM, Moseley, T, Whitman, GJ, Leung, J, Le-Petross, H, Lane, DL, Abuhadra, NK, Litton, J, Valero, V, Hunt, KK, Arun, BK, Mohamed, R, Sun, J, Korkut, A, Pashapoor, S, White, JB, Thompson, A, Wei, P, Ma, J, Moulder, S, Rauch, GM. Imaging- and Tumor Biomarker–Based Multivariable Model for Early Prediction of Pathologic Complete Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer. JCO Precision Oncology 9, 2025. e-Pub 2025. PMID: 41411609.
      5. Guirguis MS, Adrada B, Yam C, Tripathy D, Candelaria R, Yang W, Patel MM, Moseley TW, Perez F, Whitman GJ, Leung J, Le-Petross H, Lane D, Huo L, Litton J, Valero V, Hunt KK, Arun B, Mohamed R, Sun J, Korkut A, Xu Z, Pashapoor, White J, Son J, Thompson A, Wei P, Ma J, Moulder S, Rauch G. Early tumor volume reduction by breast DCE MRI predicts pathologic complete response to neoadjuvant therapy in triple negative breast cancer. NPJ Breast Cancer, 2025. e-Pub 2025. PMID: 41266347.
      6. Weaver OO, Contreras A, Cohen EO, Guirguis MS, Kapoor MM, Scoggins ME, Hwang RF, Candelaria RP, Yang WT, Dennison JB, Sun J, Whitman GJ. Assessment of pectoralis muscle invasion using combined DBT and contrast-enhanced mammography: Retrospective multi-reader study. Curr Probl Diagn Radiol 55(1):95-104, 2025. e-Pub 2025. PMID: 40288929.
      7. Xu Z, Zhou Z, Son JB, Feng H, Adrada BE, Moseley T, Candelaria RP, Guirguis MS, Patel MM, Whitman GJ, Leung J, Le-Petross HT, Mohamed,RM, Panthi B, Lane DL, Chen H, Wei P, Tripathy D, Litton JK, Valero V, Huo L, Hunt KK, Korkut A, Thompson A, Yang W, Yam C, Rauch GM, Ma J. Deep learning models based on pretreatment MRI and clinicopathological data to predict response to neoadjuvant systemic therapy in triple-negative breast cancer. Cancers (Basel), 2025. e-Pub 2025. PMID: 40149299.
      8. Musall BC, Rauch DE, Mohamed RMM, Panthi B, Boge M, Candelaria RP, Chen H, Guirguis MS, Hunt KK, Huo L, Hwang KP, Korkut A, Litton JK, Moseley TW, Pashapoor S, Patel MM, Reed BJ, Scoggins ME, Son JB, Tripathy D, Valero V, Wei P, White JB, Whitman GJ, Xu Z, Yang WT, Yam C, Adrada BE, Ma J. Diffusion Tensor Imaging for Characterizing Changes in Triple-Negative Breast Cancer During Neoadjuvant Systemic Therapy. J Magn Reson Imaging 60(4):1367-1376, 2024. e-Pub 2024. PMID: 38294179.
      9. Mohamed RM, Panthi B, Adrada BE, Boge M, Candelaria RP, Chen H, Guirguis MS, Hunt KK, Huo L, Hwang KP, Korkut A, Litton JK, Moseley TW, Pashapoor S, Patel MM, Reed B, Scoggins ME, Son JB, Thompson A, Tripathy D, Valero V, Wei P, White J, Whitman GJ, Xu Z, Yang W, Yam C, Ma J, Rauch GM. Multiparametric MRI-based radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer. Sci Rep 14(1):16073, 2024. e-Pub 2024. PMID: 38992094.
      10. Nia E, Patel M, Kapoor M, Guirguis MS, Perez F, Bassett R, Candelaria R. Comparing the performance of full-field digital mammography and digital breast tomosynthesis in the post-treatment surveillance of patients with a history of breast cancer: A retrospective study. Radiography 29(6):957-979, 2023. e-Pub 2023. PMID: 37572571.
      11. Zhou Z, Adrada BE, Candelaria RP, Elshafeey N, Boge M, Mohamed RM, Pashapoo S, Sun J, Xu Z, Panthi B, Son JB, Guirguis MS, Patel MM, Whitman GJ, Moseley T, Scoggins ME, White JB, Litton J, Valero V, Hunt KK, Tripathy D, Yang W, Wei P, Yam C, Pagel MD, Rauch GM, Ma J. Predicting pathological complete response to neoadjuvant systemic therapy for triple-negative breast cancers using deep learning on multiparametric MRIs. Annu Int Conf IEEE Eng Med Biol Soc 2023:1-4, 2023. e-Pub 2023. PMID: 38083160.
      12. Panthi B, Adrada BE, Candelaria RP, Guirguis MS, Yam C, Boge M, Chen H, Hunt KK, Huo L, Hwang KP, Korkut A, Lane DL, Le-Petross HC, Leung JWT, Litton JK, Mohamed RM, Musall BC, Pashapoor S, Patel MM, Perez F, Son JB, Thompson A, Valero V, Wei P, White J, Xu Z, Pinsky L, Tripathy D, Yang W, Ma J, Rauch GM. Assessment of response to neoadjuvant systemic treatment in triple-negative breast cancer using functional tumor volumes from longitudinal dynamic contrast-enhanced MRI. Cancers (Basel) 15(4):1025, 2023. e-Pub 2023. PMID: 36831368.
      13. Zhou Z, Adrada BE, Candelaria RP, Elshafeey NA, Boge M, Mohamed RM, Pashapoor S, Sun J, Xu Z, Panthi B, Son JB, Guirguis MS, Patel MM, Whitman GJ, Moseley TW, Scoggins ME, White JB, Litton JK, Valero V, Hunt KK, Tripathy D, Yang W, Wei P, Yam C, Pagel MD, Rauch GM, Ma J. Prediction of pathologic complete response to neoadjuvant systemic therapy in triple negative breast cancer using deep learning on multiparametric MRI. Sci Rep 13(1):1171, 2023. e-Pub 2023. PMID: 36670144.
      14. Guirguis MS, Checka C, Adrada BE, Whitman GJ, Dryden MJ, Sun J, Ding QQ, Le-Petross H, Rauch GM, Clemens M, Moseley TW. Bracketing with multiple radioactive seeds to achieve negative margins in breast conservation surgery: Multiple seeds in breast surgery. Clin Breast Cancer 22(2):e158-e166, 2022. e-Pub 2022. PMID: 34187752.
      15. Candelaria RP, Spak DA, Rauch GM, Huo L, Bassett RL, Santiago L, Scoggins ME, Guirguis MS, Patel MM, Whitman GJ, Moulder SL, Thompson AM, Ravenberg EE, White JB, Abuhadra NK, Valero V, Litton J, Adrada BE, Yang WT. BI-RADS ultrasound lexicon descriptors and stromal tumor-infiltrating lymphocytes in triple-negative breast cancer. Acad Radiol 29 Suppl 1(Suppl 1):S35-S41, 2022. e-Pub 2022. PMID: 34272161.
      16. Guirguis MS, Shroff GS. Cement pulmonary embolism. Am J Med Sci 349(5):e5, 2015. e-Pub 2015. PMID: 24534786.
      17. Lindsey JW, Khan U, Ansari W, Powell T, Wang YH, Guirguis MS. The antibody response to Epstein-Barr virions is altered in multiple sclerosis. J Neuroimmunol 15(254):146-53, 2013. e-Pub 2013. PMID: 23026221.

      Invited Articles

      1. Patel MM, Le-Petross HT, Kapoor MM, Farag JA, Whitman G, Guirguis MS. Current Imaging Approaches in Inflammatory Breast Cancer. Curr Breast Cancer Rep 16:142-149, 2024. e-Pub 2024.
      2. Ferreira Dalla Pria HR, Scoggins ME, Moseley TW, Vishwanath V, Jean S, Vuong S, Diaz V, Elhatw A, Patel MM, Guirguis MS. Current status of imaging for breast cancer staging. Curr Breast Cancer Rep 16(1):126-133, 2024. e-Pub 2024.
      3. Chung HL, Joiner J, Pria HR, Jean S, Vishwanath V, De Jesus C, Elhatw A, Guirguis MS, Patel MM, Moseley TW. Breast imaging considerations in symptomatic young, pregnant, and lactating women. Curr Breast Cancer Rep 15(2):119-126, 2023. e-Pub 2023.
      4. DeJesus C, Moseley TW, Diaz V, Vishwanath V, Jean S, Elhatw A, Ferreira Dalla Pria HR, Chung HL, Guirguis MS, Patel MM. Supplemental screening for breast cancer. Curr Breast Cancer Rep 15(2):97-102, 2023. e-Pub 2023.
      5. De Jesus C, Moseley TW, Diaz V, Vishwanath V, Jean S, Elhatw A, Ferreira Dalla Pria HR, Chung HL, Guirguis MS, Patel MM. The benefits of screening mammography. Curr Breast Cancer Rep 15(2):103-107, 2023. e-Pub 2023.
      6. Elhatw A, Chung HL, Kamal RM, De Jesus C, Jean S, Vishwanath V, Ferreira Dalla Pria HR, Patel MM, Guirguis MS, Moseley TW. Advanced breast imaging modalities — DBT, CEM, MBI, PEM, MRI, AI. Curr Breast Cancer Rep 15(2):108-113, 2023. e-Pub 2023.

      Review Articles

      1. Moseley TW, Adrada B, Arribas E, Urban M, Hesley G, Whitman G, Rauch R, Guirguis MS, Kapoor M, Lee C. Selection of breast biopsy markers: Effect on breast imaging procedures, follow-up, and costs. RadioGraphics, 2026. e-Pub 2026. PMID: 42594023.
      2. Moseley TW, Rauch RA, Whitman GJ, Arribas EM, Guirguis MS, Adrada B. Hematologic malignancies of the breast. R3 Roentgen Ray Review, 2026. e-Pub 2026.
      3. Moseley TW, Adrada BE, Arribas E, Chung H, Kapoor MM, Patel MM, Ghannam S, Guirguis MS. Solitary dilated ducts 2.0 – Multimodality imaging detection, assessment, and management. J Breast Imaging 7(5):606-618, 2025. e-Pub 2025. PMID: 40884407.
      4. Arribas E, Moseley T, Guirguis MS, Kapoor M, Nia E, Rauch G, Patel MM, Adrada B. Beyond metastatic lymphadenopathy in breast cancer: An approach to axillary masses. RadioGraphics. e-Pub 2025.
      5. Patel MM, Adrada BE, Guirguis MS, Whitman G, Moseley TW, Rauch GM. Current Concepts in Molecular Breast Imaging. J Breast Imaging 7(1):104-118, 2025. e-Pub 2025. PMID: 39692400.
      6. Fazeli S, Stepenosky J, Guirguis MS, Adrada B, Rakow-Penner R, Ojeda-Fournier H. Understanding BI-RADS Category 3. Radiographics 45(1):e240169, 2025. e-Pub 2025. PMID: 39636752.
      7. Guirguis MS, Arribas EM, Kapoor MM, Patel MM, Perez F, Nia ES, Ding Q, Moseley TW, Adrada BE. Multimodality Imaging of Benign and Malignant Diseases of the Nipple-Areolar Complex. Radiographics 44(4):e230113, 2024. e-Pub 2024. PMID: 38483829.
      8. Patel MM, Adrada BE, Nia ES, Kapoor MM, Khazai L, Guirguis MS, Perez F, Moseley T, Arribas E. Multimodality imaging of breast cancer recurrence post breast conservation therapy. Current Radiology Reports 12(2):9-18, 2024. e-Pub 2024.
      9. Adrada BE, Moseley TW, Kapoor MM, Scoggins ME, Patel MM, Perez F, Nia ES, Khazai L, Arribas E, Rauch GM, Guirguis MS. Triple-Negative breast cancer: A review of histopathology, genomics, and treatment. Radiographics 43(10):e230034, 2023. e-Pub 2023. PMID: 37792593.
      10. Guirguis MS, Yang WT. Overview of incidental breast lesions. Br J Radiol 96(1142):20211326, 2023. e-Pub 2023. PMID: 35451861.
      11. Guirguis MS, Adrada BE, Scoggins ME, Moseley TW, Dryden MJ, Le-Petross HC, Rauch GM, Whitman GJ. The challenging image-guided preoperative breast localization: A modality-based approach. AJR Am J Roentgenol 218(3):1-12, 2022. e-Pub 2022. PMID: 34612680.
      12. Adrada BE, Guirguis MS, Hoang T, Spak DA, Rauch GM, Moseley TW. MRI-guided breast biopsy case-based review: Essential techniques and approaches to challenging cases. RadioGraphics 42(2):210126, 2022. e-Pub 2022. PMID: 35119965.
      13. Noreña-Rengifo BD, Sanín-Ramírez MP, Adrada BE, Luengas AB, Martínez de Vega V, Guirguis MS, Saldarriaga-Uribe C. MRI for evaluation of complications of breast augmentation. RadioGraphics 42(4):210096, 2022. e-Pub 2022. PMID: 35559662.
      14. Teichgraeber DC, Guirguis MS, Whitman GJ. Breast cancer staging: Updates in the AJCC Cancer Staging Manual 8th Edition and Current Challenges for Radiologists, From the AJR Special Series on Cancer Staging. AJR Am J Roentgenol 217(2):278-290, 2021. e-Pub 2021. PMID: 33594908.
      15. Guirguis MS, Adrada B, Santiago L, Candelaria RP, Arribas E. Mimickers of breast malignancy: Imaging findings, pathologic concordance and clinical management. Insights Imaging 12(1):53, 2021. e-Pub 2021. PMID: 33877461.
      16. Guirguis MS, Adrada BE, Surasi DS, Dryden MJ. 68Ga-DOTATATE uptake in primary breast cancer. Clin Nucl Med 46(3):248-249, 2021. e-Pub 2021. PMID: 33234932.
      17. Teichgraeber DC, Perez F, Guirguis MS, Kapoor MM, Whitman GJ. Ultrasound evaluation of the axilla in the breast imaging setting. Ultrasound Q 37(1):43-51, 2021. e-Pub 2021. PMID: 33464028.
      18. Riascos R, Bonfante E, Cotes C, Guirguis MS, Hakimelahi R, West C. Imaging of atlanto-occipital and atlantoaxial traumatic injuries: What the radiologist needs to know. RadioGraphics 35(7):2121-34, 2015. e-Pub 2015. PMID: 26562241.
      19. Shroff GS, Guirguis MS, Ocazionez D, Oldham SA, Restrepo CS, Chiles C. Beyond metastatic disease: A pictorial review of multinodular lung disease with computed tomographic pathologic correlation. Can Assoc Radiol J 66(1):16-23, 2015. e-Pub 2015. PMID: 25623007.
      20. Shroff GS, Guirguis MS, Ferguson EC, Oldham SA, Kantharia BK. CT imaging of complications of catheter ablation for atrial fibrillation. Clin Radiol 69(1):96-102, 2014. e-Pub 2014. PMID: 24268510.

      Professional Educational Materials

      1. Adrada BA, Kapoor MM, Guirguis MS. Breast Implants: Imaging Insights and Complications. The American Roentgen Ray Society.

      Other Articles

      1. Adrada, BE, Guirguis, MS, Huo, L, Yam, C, Tripathy, D, Candelaria, RP, Yang, W, Patel, MM, Moseley, T, Whitman, GJ, Leung, J, Le-Petross, H, Lane, DL, Abuhadra, NK, Litton, J, Valero, V, Hunt, KK, Arun, BK, Mohamed, R, Sun, J, Korkut, A, Pashapoor, S, White, JB, Thompson, A, Wei, P, Ma, J, Moulder, S, Rauch, GM Erratum. JCO Precision Oncology 10(5), 2026. PMID: 42150150.

      Letters to the Editor

      1. Guirguis MS, Adrada BE, Scoggins ME, Moseley TW, Whitman GJ. Reply to "Additional references relevant to preoperative breast lesion localization techniques". AJR Am J Roentgenol 218: 1, 2022.
      2. Shroff GS, Guirguis MS, Ferguson EC, Oldham SA, Kantharia BK. Re: CT imaging of complications of catheter ablation for atrial fibrillation. A reply. Clin Radiol 69: 369, 2014.
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