Mary Kaye Martel, Ph.D., FAAPM, FASTRO
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Department Chair, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Dr. Martel's current research interests are in radiation dose-response studies, outcome analysis and biological modeling. She is interested in normal tissue toxicity risk assessment in anatomical sites such as the thorax, head, and head and central nervous system. She is also interested in tumor control probability modeling. This work includes information from functional imaging, genetic information such as SNP's, and other biological information such as cytokines. Her research group is developing a novel program to treat advanced nonsmall cell lung cancer with personalized adaptive radiation.
Education & Training
Degree-Granting Education
| 1982 | Clark University, Worcester, MA, USA, PHD, Nuclear Chemistry |
Postgraduate Training
| 2010-2010 | Heart of Leadership Program, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2009-2009 | Mid-career Women Faculty Professional Development Seminar, Association of American Medical Colleges/Harvard Medical School, Scottsdale, AZ |
| 1982-1984 | Postdoctoral Fellowship, Memorial Sloan-Kettering, New York City, NY |
Board Certifications
| 1986 | American Board of Radiology |
Experience & Service
Administrative Appointments/Responsibilities
Department Chair ad interim, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2019
Director of Faculty Support, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2017
Physics Liaison, MD Anderson Banner Cancer Center, Phoenix, AZ, 2011 - 2015
Institutional Committee Activities
Member, Faculty Search Committee, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 2012 - 2015
Mentor, CPRIT Scholar Program, MD Anderson, 2012 - 2014
Member, Faculty Search Committee, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 2010 - 2015
Member, Clinical Faculty Review Committee (CFRC) Institutional, The University of Texas MD Anderson Cancer Center, 2010 - 2013
Member, Credentials Committee of the Medical Staff (CCMS), The University of Texas MD Anderson Cancer Center, 2010 - 2011
Member, Institutional Review Grants Review Committee (IRG), The University of Texas MD Anderson Cancer Center, 2010 - 2015
Member, 2008-2010; Chair, Credentialing Committee, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 2009 - 2010
Member, Research Funding Review Panel, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 2009 - 2010
Senator (elected), Faculty Senate Travel Advisory Committee, The University of Texas MD Anderson Cancer Center, 2009 - 2016
Chair, Rapidarc/VMAT Implementation Team, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 2009 - 2011
Member, Medical Physics Residency Steering Committee, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 2008 - Present
Member, Radiation Oncology Access Database Committee, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 2008 - Present
Senator (elected), Faculty Senate, Institutional Committee, The University of Texas MD Anderson Cancer Center, 2008 - 2011
Member, Physicist-Scientist Oversight Committee, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 2008 - 2010
Member, Leadership Council, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 2007 - 2015
Member, Clinical Operations Committee, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 2007 - Present
Member, Research Mentorship Committee, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 2007 - Present
Honors & Awards
| 2008 | Society of Pediatric Radiology Presidential Recognition Award |
| 2008 | Fellow, American Society of Therapeutic Radiation Oncology |
| 2001 | Fellow, American Association of Physicists in Medicine |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Tucker SL, Liao Z, Dinh J, Bian SX, Mohan R, Martel MK, Grosshans DR. Is there an impact of heart exposure on the incidence of radiation pneumonitis? Analysis of data from a large clinical cohort. Acta Oncol 53(5):590-596, 2014. e-Pub 2013. PMID: 23992110.
- Tang C, Liao Z, Zhuang Y, Levy LB, Hung C, Li X, Krafft SP, Martel MK, Komaki R, Gomez DR. Acute phase response before treatment predicts radiation esophagitis in non-small cell lung cancer. Radiother Oncol 110(3):493-8, 2014. e-Pub 2014. PMID: 24560756.
- Hunter LA, Krafft S, Stingo F, Choi H, Martel MK, Kry SF, Court LE. High quality machine-robust image features: Identification in nonsmall cell lung cancer computed tomography images. Med Phys 40(12):121916, 2013. PMID: 24320527.
- Vinogradskiy Y, Castillo R, Castillo E, Tucker SL, Liao Z, Guerrero T, Martel MK. Use of 4-Dimensional Computed Tomography-Based Ventilation Imaging to Correlate Lung Dose and Function With Clinical Outcomes. Int J Radiat Oncol Biol Phys 86(2):366-71, 2013. e-Pub 2013. PMID: 23474113.
- Vinogradskiy Y, Tucker SL, Liao Z, Martel MK. Balancing radiation pneumonitis versus locoregional tumor control in non-small-cell lung cancer. J Thorac Oncol 8(5):e47-8, 2013. PMID: 23584304.
- Court LE, Tucker SL, Gomez D, Liao Z, Zhang J, Kry S, Dong L, Martel MK. A technique to use CT images for in vivo detection and quantification of the spatial distribution of radiation-induced esophagitis. J Appl Clin Med Phys 14(3):4195, 2013. e-Pub 2013. PMID: 23652249.
- Evans JD, Gomez DR, Amini A, Rebueno N, Allen PK, Martel MK, Rineer JM, Ang KK, McAvoy S, Cox JD, Komaki R, Welsh JW. Aortic dose constraints when reirradiating thoracic tumors. Radiother Oncol 106(3):327-32, 2013. e-Pub 2013. PMID: 23453540.
- Tucker SL, Mohan R, Liengsawangwong R, Martel MK, Liao Z. Predicting Pneumonitis Risk: A Dosimetric Alternative to Mean Lung Dose. Int J Radiat Oncol Biol Phys 85(2):522-7, 2013. e-Pub 2012. PMID: 22580121.
- Tucker SL, Li M, Xu T, Gomez D, Yuan X, Yu J, Liu Z, Yin M, Guan X, Wang LE, Wei Q, Mohan R, Vinogradskiy Y, Martel M, Liao Z. Incorporating Single-nucleotide Polymorphisms Into the Lyman Model to Improve Prediction of Radiation Pneumonitis. Int J Radiat Oncol Biol Phys 85(1):251-7, 2013. e-Pub 2012. PMID: 22541966.
- Gomez DR, Tucker SL, Martel MK, Mohan R, Balter PA, Lopez Guerra JL, Liu H, Komaki R, Cox JD, Liao Z. Predictors of High-grade Esophagitis After Definitive Three-dimensional Conformal Therapy, Intensity-modulated Radiation Therapy, or Proton Beam Therapy for Non-small cell Lung Cancer. Int J Radiat Oncol Biol Phys 84(4):1010-6, 2012. e-Pub 2012. PMID: 22920974.
- Vinogradskiy Y, Tucker SL, Bluett JB, Wages CA, Liao Z, Martel MK. Prescribing radiation dose to lung cancer patients based on personalized toxicity estimates. J Thorac Oncol 7(11):1676-82, 2012. PMID: 23059778.
- Jiang ZQ, Yang K, Komaki R, Wei X, Tucker SL, Zhuang Y, Martel MK, Vedam S, Balter P, Zhu G, Gomez D, Lu C, Mohan R, Cox JD, Liao Z. Long-term clinical outcome of intensity-modulated radiotherapy for inoperable non-small cell lung cancer: The MD Anderson experience. Int J Radiat Oncol Biol Phys 83(1):332-339, 2012. e-Pub 2011. PMID: 22079735.
- Vinogradskiy Y, Tucker SL, Liao Z, Martel MK. Investigation of the relationship between gross tumor volume location and pneumonitis rates using a large clinical database of non-small-cell lung cancer patients. Int J Radiat Oncol Biol Phys 82(5):1650-1658, 2012. e-Pub 2011. PMID: 21497454.
- Vinogradskiy Y, Tucker SL, Liao Z, Martel MK. A novel method to incorporate the spatial location of the lung dose distribution into predictive radiation pneumonitis modeling. Int J Radiat Oncol Biol Phys 82(4):1549-1555, 2012. e-Pub 2011. PMID: 21741183.
- Tucker SL, Jin H, Wei X, Wang S, Martel MK, Komaki R, Liu HH, Mohan R, Chen Y, Cox JD, Liao Z. Impact of Toxicity grade and scoring system on the relationship between mean lung dose and risk of radiation pneumonitis in a large cohort of patients with non-small cell lung cancer. Int J Radiat Oncol Biol Phys 77(3):691-8, 2010. e-Pub 2009. PMID: 19836159.
- Du W, Yang JN, Chang EL, Luo D, McAleer MF, Shiu A, Martel MK. A quality assurance procedure to evaluate cone-beam CT image center congruence with the radiation isocenter of a linear accelerator. J Appl Clin Med Phys 11(4):15-26, 2010. e-Pub 2010. PMID: 21081890.
- Du W, Yang J, Luo D, Martel M. A simple method to quantify the coincidence between portal image graticules and radiation field centers or radiation isocenter. Med Phys 37(5):2256-63, 2010. PMID: 20527559.
- Mayo C, Martel MK, Marks LB, Flickinger J, Nam J, Kirkpatrick J. Radiation dose volume effects of optic nerves and chiasm. Int J Radiat Oncol Biol Phys 76(3 Suppl):28-35, 2010. PMID: 20171514.
- Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS, El Naqa I, Hubbs JL, Lebesque JV, Timmerman RD, Martel MK, Jackson A. Radiation dose volume effects in the lung. Int J Radiat Oncol Biol Phys 76(3 Suppl):70-76, 2010. PMID: 20171521.
- Liao ZX, Komaki RR, Thames HD, Liu HH, Tucker SL, Mohan R, Martel MK, Wei X, Yang K, Kim ES, Blumenschein G, Hong WK, Cox JD. Assessing the impact of technologic advancement on outcome for patients with unresectable locally advanced non-small-cell lung cancer (NSCLC) receiving concomitant chemo radiotherapy. Int J Radiat Oncol Biol Phys 76(3):775-81, 2010. e-Pub 2009. PMID: 19515503.
- Marks LB, Ten Haken RK, Martel MK. Guest Editor's Introduction to QUANTEC: a user's guide. Int J Radiat Oncol Biol Phys 76(3 Suppl):1-2, 2010. PMID: 20171501.
- Jin H, Tucker SL, Liu HH, Wei X, Yom SS, Wang S, Komaki R, Chen Y, Martel MK, Mohan R, Cox JD, Liao Z. Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy. Radiother Oncol 91(3):427-32, 2009. e-Pub 2008. PMID: 18937989.
- Cao J, Roeske JC, Chmura SJ, Salama JK, Shoushtari AN, Boyer AL, Martel MK. Calculation and prediction of the effect of respiratory motion on whole breast radiation therapy dose distributions. Med Dosim 34(2):126-132, 2009. e-Pub 2008. PMID: 19410141.
- Yuan X, Liao Z, Liu Z, Wang LE, Tucker SL, Mao L, Wang XS, Martel M, Komaki R, Cox JD, Milas L, Wei Q. Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy. J Clin Oncol 27(20):3370-8, 2009. e-Pub 2009. PMID: 19380441.
- Videtic GM, Belderbos JS, Spring Kong FM, Kepka L, Martel MK, Jeremic B. Report from the International Atomic Energy Agency (IAEA) consultants' meeting on elective nodal irradiation in lung cancer: small-cell lung cancer (SCLC). Int J Radiat Oncol Biol Phys 72(2)(2):327-334, 2008. PMID: 18793952.
- Tucker SL, Liu HH, Liao Z, Wei X, Wang S, Jin H, Komaki R, Martel MK, Mohan R. Analysis of radiation pneumonitis risk using a generalized lyman model. Int J Radiat Oncol Biol Phys 72(2)(2):568-574, 2008. PMID: 18793959.
- Wang X, Krishnan S, Zhang X, Dong L, Briere T, Crane CH, Martel M, Gillin M, Mohan R, Beddar S. Proton radiotherapy for liver tumors: dosimetric advantages over photon plans. Med Dosim 33(4)(4):259-267, 2008. PMID: 18973852.
- Aristophanous M, Penney BC, Martel MK, Pelizzari CA. A Gaussian mixture model for definition of lung tumor volumes in positron emission tomography. Med Phys 34(11)(11):4223-4235, 2007. PMID: 18072487.
- Jani AB, Gratzle J, Muresan E, Farrey K, Martel MK. Analysis of acute toxicity with the use of transabdominal ultrasound for prostate positioning during intensity-modulated radiotherapy treatment. Urology 65(3):504-8, 2005. PMID: 15780365.
- Jani AB, Gratzle J, Muresan E, Martel MK. Impact on late toxicity on using transabdominal ultrasound for prostate cancer patients treated with intensity modulated radiotherapy. Technol Cancer Res Treat 4(1):115-20, 2005. PMID: 15649095.
- Narayan S, Henning GT, Ten Haken RK, Sullivan MA, Martel MK, Hayman JA. Results following treatment to doses of 92.4 or 102.9 Gy on a phase I does escalation study for non-small cell lung cancer. Lung Cancer 44(1):79-88, 2004. PMID: 15013586.
- Martel MK. Advanced radiation treatment planning and delivery approaches for treatment of lung cancer. Hematol Oncol Clin North Am 18(1):231-243, 2004. PMID: 15005291.
- Seppenwoolde Y, Lebesque JV, de Jaeger K, Belderbos JS, Boersma LJ, Schilstra C, Henning GT, Hayman JA, Martel MK, Ten Haken RK. NTCP models and the incidence of radiation pneumonitis. Int J Radiat Oncol Biol Phys 55(3):724-735, 2003. PMID: 12573760.
- Pierce LJ, Butler JB, Martel MK, Normolle DP, Koelling T, Marsh RB, Lichter AS, Fraass BA. Post mastectomy radiotherapy of the chest wall: dosimetric comparison of common techniques. Int J Radiat Oncol Biol Phys 52(5)(5):1220-30, 2002. PMID: 11955732.
- Graves MN, Thompson AV, Martel MK, McShan DL, Fraass BA. Calibration and quality assurance for rounded leaf-end MLC systems. Med Phys 28(1)(11):2227-33, 2001. PMID: 11764026.
- Hayman JA, Martel MK, Ten Haken RK, Normolle DP, Todd RF, Littles JF, Sullivan MA, Possert PW, Turrisi AT, Lichter AS. Dose escalation in non-small-cell lung cancer using three-dimensional conformal radiation therapy: update of a phase I trial. J Clin Oncol 19(1)(1):127-36, 2001. PMID: 11134205.
- Martel MK, Ten Haken RK, Hazuka MB, Kessler ML, Strawderman M, Turrisi AT, Lawrence TS, Fraass BA, Lichter AS. Estimation of tumor control probability model parameters from 3D dose distributions of nonsmall cell lung cancer patients. Lung Cancer 24(1)(1):31-37, 1999. PMID: 10403692.
- Lee SW, Fraass BA, Marsh LH, Herbort K, Gebarski SS, Martel MK, Radany EH, Lichter AS, Sandler HM. Patterns of failure following high-dose 3D conformal radiotherapy for high-grade astrosytomas: a quantitative dosimetric study. Int J Radiat Oncol Biol Phys 43:79-88, 1999.
- Eisbruch A, Dawson LA, Kim HM, Bradford CR, Terrell JE, Chepeha DB, Teknos TN, Anzai Y, Marsh LH, Martel MK, Ten Haken RK, Wolf GT, Ship JA. Conformal and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life. Acta Otorhinolaryngol Belg 53(3)(3):271-5, 1999. PMID: 10635407.
- Fukunaga-Johnson N, Sandler HS, Marsh R, Martel MK. The use of 3-D conformal radiotherapy (3DCRT) to spare the cochlea in patients with meulloblastoma. Int J Radiat Oncol Biol Phys 41:77-82, 1998.
- Eisbruch A, Johnston CM, Martel MK, Reynolds KR, Robertson JM, Marsh LH, Roberts JA. Customized gynecologic interstitial implants: CT-based planning, dose evaluation and optimization aided by laparatomy. Int J Radiat Oncol Biol Phys 40:1087-1093, 1998.
- Martel MK, Strawderman M, Hazuka MB, Turrisi AT, Fraass BA, Lichter AS. Volume and dose parameters for survival of nonsmall cell lung cancer patients. Radiother Oncol 44(1):23-30, 1997. PMID: 9288853.
- Martel MK, Sandler HM, Cornblath WT, Marsh LH, Hazuka MB, Roa WH, Fraass BA, Lichter AS. Dose-volume complication analysis for visual pathway structures of patients with advanced paranasal sinus tumors. Int J Radiat Oncol Biol Phys 38(2):273-84, 1997. PMID: 9226313.
- Robertson JM, Ten Haken RK, Hazuka MB, Turrisi AT, Martel MK, Pu AT, Littles JF, Martinez FJ, Francis IR, Quint LE, Lichter AS. Dose escalation for nonsmall cell lung cancer using conformal radiation therapy. Int J Radiat Oncol Biol Phys 37(5):1079-1085, 1997. PMID: 9169816.
- Marsh L, Eisbruch A, Watson B, Martel MK. Treatment planning for parotid sparing int he patient requiring bilateral neck irradiation. Med Dosim 21(1):7-13, 1996. PMID: 8679070.
- Martel MK, Ten Haken RK, Hazuka MB, Turrisi AT, Fraass BA, Lichter AS. Dose-volume histogram and 3-D treatment planning evaluation of patients with pneumonitis. Int J Radiat Oncol Biol Phys 28(3):575-581, 1994. PMID: 8113100.
- Schoeppel SL, LaVigne ML, Martel MK, McShan DL, Fraass BA, Roberts JA. Three-dimensional treatment planning of intracavitary gynecologic implants: analysis of ten cases and implications for dose specification. Int J Radiat Oncol Biol Phys 28(1):277-283, 1994. PMID: 8270452.
- Hazuka MB, Martel MK, Marsh L, Lichter AS, Wolf GT. Preservation of parotid function after external beam irradiation in head and neck cancer patients: a feasibility study using 3-dimensional treatment planning. Int J Radiat Oncol Biol Phys 27(3):731-737, 1993. PMID: 8226171.
- Ten Haken RK, Martel MK, Kessler ML, Hazuka MB, Lawrence TS, Robertson JM, Turrisi AT, Lichter AS. Use of Veff and iso-NTCP in the implementation of dose escalation protocols. Int J Radiat Oncol Biol Phys 27(3):689-695, 1993. PMID: 8226166.
Abstracts
- Vinogradskiy Y, Tucker SL, Xhongxing L, Martel MK. Using Genetically-based Normal Tissue Toxicity Models to Personalize Prescription Dose: A Proof of Principle Virtual Study. ASTRO 84(3):S155, 2012.
- Liao Z, Tucker, SL, Gomez D, Grosshans DR, Zhuang Y, Krafft SP, Martel MK, Mohan R, Komaki R, Cox JD. Heart and Lung Radiation and Overall Survival in Non-small Cell Lung Cancer Patients After Chemoradiation Therapy. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 84(3):S578, 2012.
- Vinogradskiy Y, Castillo R, Castillo E, Tucker S, Zhongxing L, Guerrero T, Martel MK. Using 4DCT-Based Ventilation Imaging to Correlate Lung Dose and Function with Clinical Outcomes. AAPM 39(6):3948, 2012. PMID: 22757298.
- Wang H, Wang C, Wong P, Martel M, Chung H, Tung S. Comparison of Dosimetric Effect of Translational Setup Errors for Total Scalp Irradiation Using Conventional Photon-Electron Combination, IMRT and VMAT Techniques,. AAPM, 2011.
- Wang C, Wang H, Tung S, Chung H, Wong P, Martel M. Total Scalp Irradiation Using Volumetric Modulated Arc Therapy and Comparison with IMRT and Conventional Photon/Electron Field Combination. AAPM, 2011.
- Court L, Tucker S, Govez D, Liao Z, Zhang L, Kry S, Martel M, Dong L. A Novel Technique to Use CT Images for in Vivo Detection and Quantification of the Spatial Distribution of Radiation-Induced Damage to the Esophagus. AAPM, 2011.
- Vinogradskiy Y, Castillo R, Castillo E, Chandler A, Martel M, Guerrero T. Use of Weekly 4DCT-Based Ventilation Maps to Quantify Changes in Lung Function for Patients Undergoing Radiation Therapy. AAPM, 2011.
- Briere T, Vinogradskiy Y, Tucker S, Liao Z, Martel M. Absolute Lung Volume Considerations for Radiation Pneumonitis. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 81(2):S51, 2011.
- Lopez J, Gomez D, Shuang Y, Levy I, Martel M, Liu H, Mohan R, Komaki R, Cox J. A comparison of the changes in diffusing capacity of the lung for carbon monoxide after definitive radiation for non-small cell lung cancer with three different modern techniques: 3D conformal therapy, intensity modulated radiation therapy, and proton beam therapy. ASTRO, 2011.
- Court L, Gomez D, Liao X, Tucker S, Dong L, Martel M. Quantitative analysis of esophageal toxicity using CT images. ASTRO, 2011.
Book Chapters
- Martel M. 3D Conformal Treatment Planning and Execution. In: Advances in Radiation Oncology in Lung Cancer. Springer-Verlag, 2011.
- Kong FM, Bradley JD, Martel MK, Senan S. Cancers of the Thorax. In: Treatment Planning in Radiation Oncology. Second. Lippincott Williams & Wilkins: New York, 2006.
- Martel MK. QA of the Treatment Planning Process. In: Proceedings of the Quality Assurance in Novel Technologies in Radiation Medicine (QANTRM). IAEA: Vienna, 2006.
- Martel MK. Treatment planning and Conformal Radiotherapy. In: Advances in Radiation Oncology in Lung Cancer. Springer-Verlag, 2004.
- Connell P, Martel MK, Hellman S. Principles of Radiation Oncology. In: Principles and Practice of Oncology. Lippincott Williams and Wilkins, 2004.
- Martel MK, Graham MV. Dose volume histograms and normal tissue complication probabilities and their clinical applications. In: Treatment Optimization for Lung Cancer: from classical to innovative procedures. Elsevier: Paris, France, 1998.
- Rosenman J, Hazuka MB, Martel MK. 3-D Treatment Planning for Lung Cancer. In: Lung Cancer: Principles and Practice. Lippincott Publishers, 1995.
Grant & Contract Support
| Title: | Optimizing Proton Radiation Therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator/PI |
Patient Reviews
CV information above last modified August 21, 2024