Mihai Gagea Iurascu, DVM, DVSc, DACVP, DABT

Peer-Reviewed Articles

1. Xu, T, Xu, T, Chakraborty Patra, S, Chakraborty Patra, S, Wei, D, Wei, D, Tran, M, Tran, M, Rhea, R, Rhea, R, Wei, B, Wei, B, Nguyen, P, Nguyen, P, Gagea Iurascu, M, Gagea Iurascu, M, Xie, X, Xie, X, Wu, Lr, Wu, Lr, Cohen, L, Cohen, L, Liao, Z, Liao, Z, Yang, P, Yang, P. Evaluation of the protective effect of Compound Kushen Injection against radiation‑induced lung injury in mice. Molecular medicine reports 31(4), 2025. e-Pub 2025. PMID: 39917996.
2. Li W, Saleh NA, Gao C, Gagea MA, Vitija X, Kanada M, Deng CX. Dynamic reorganization of multivesicular bodies and exosome production impacted by sonoporation. Sci Rep 14(1):27432, 2024. e-Pub 2024. PMID: 39521850.
3. Treekitkarnmongkol, W, Shah, V, Kai, K, Katayama, H, Wong, J, Ladha, FA, Nguyen, T, Menegaz, BA, Lu, W, Yang, F, Mino, B, Tang, X, Gagea Iurascu, M, Batra, H, Raso, G, Wistuba, II, Krishnamurthy, S, Pinder, SE, Sawyer, EJ, Thompson, A, Sen, S. Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer. British journal of cancer 131(1):171-183, 2024. e-Pub 2024. PMID: 38760444.
4. Pourebrahim, R, Montoya, RH, Akiyama, H, Ostermann, LB, Khazaei, S, Muftuoglu, M, Baran, N, Zhao, R, Lesluyes, T, Liu, B, Khoury, J, Gagea Iurascu, M, Van Loo, P, Andreeff, M. Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice. Cell Reports Medicine 5(5), 2024. e-Pub 2024. PMID: 38733986.
5. Xu T, Chakraborty S, Wei D, Tran M, Rhea R, Wei B, Nguyen P, Gagea M, Cohen L, Liao Z, Yang P. Evaluation of the Protective Effect of Compound Kushen Injection Against Radiation- induced Pneumonitis in Mice. Res Sq, 2024. e-Pub 2024. PMID: 38352564.
6. Schwartz-Duval, AS, Mackeyev, YA, Mahmud, I, Lorenzi, PL, Gagea Iurascu, M, Krishnan, S, Sokolov, KV. Intratumoral Biosynthesis of Gold Nanoclusters by Pancreatic Cancer to Overcome Delivery Barriers to Radiosensitization. ACS Nano 18(3):1865-1881, 2024. e-Pub 2024. PMID: 38206058.
7. Dolapchiev LI, Gonzales KA, Cruz LR, Gagea M, Stevenson HL, Kwan SY, Beretta L. Gut Microbiome and Hepatic Transcriptomic Determinants of HCC Development in Mice with Metabolic Dysfunction-Associated Steatohepatitis. J Hepatocell Carcinoma 11:1891-1905, 2024. e-Pub 2024. PMID: 39372712.
8. Treekitkarnmongkol, W, Solis Soto, LM, Sankaran, D, Gagea Iurascu, M, Singh, P, Mistry, R, Nguyen, T, Kai, K, Liu, J, Sasai, K, Jitsumori, Y, Liu, J, Nagao, N, Stossi, F, Mancini, MA, Wistuba, II, Thompson, AM, Lee, JM, Cadiñanos, J, Wong, KK, Abbott, CM, Sahin, AA, Liu, S, Katayama, H, Sen, S. eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer. Science signaling 17(826), 2024. e-Pub 2024. PMID: 38442201.
9. Dibra, D, Gagea Iurascu, M, Qi, Y, Chau, GP, Su, X, Lozano, G. p53R245W Mutation Fuels Cancer Initiation and Metastases in NASH-driven Liver Tumorigenesis. Cancer Research Communications 3(12):2640-2652, 2023. e-Pub 2023. PMID: 38047594.
10. Mahadevan KK, LeBleu VS, Ramirez EV, Chen Y, Li B, Sockwell AM, Gagea M, Sugimoto H, Sthanam LK, Tampe D, Zeisberg M, Ying H, Jain AK, DePinho RA, Maitra A, McAndrews KM, Kalluri R. Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells. Dev Cell 58(17):1562-1577.e8, 2023. e-Pub 2023. PMID: 37625403.
11. Liu S, Xie SM, Liu W, Gagea M, Hanker AB, Nguyen N, Singareeka Raghavendra A, Yang-Kolodji G, Chu F, Neelapu SS, Marchese A, Hanash S, Zimmermann J, Arteaga CL, Tripathy D. Targeting CXCR4 abrogates resistance to trastuzumab by blocking cell cycle progression and synergizes with docetaxel in breast cancer treatment. Breast Cancer Res 25(1):62, 2023. e-Pub 2023. PMID: 37280713.
12. Perez GI, Bernard MP, Vocelle D, Zarea AA, Saleh NA, Gagea MA, Schneider D, Bauzon M, Hermiston T, Kanada M. Phosphatidylserine-Exposing Annexin A1-Positive Extracellular Vesicles: Potential Cancer Biomarkers. Vaccines (Basel) 11(3), 2023. e-Pub 2023. PMID: 36992223.
13. Liu S, Xie SM, Liu W, Gagea M, Hanker AB, Nguyen N, Raghavendra AS, Yang-Kolodji G, Chu F, Neelapu SS, Hanash S, Zimmermann J, Arteaga CL, Tripathy D. Targeting CXCR4 abrogates resistance to trastuzumab by blocking cell cycle progression and synergizes with docetaxel in breast cancer treatment. Res Sq, 2023. e-Pub 2023. PMID: 36824840.
14. Kwan SY, Slayden AN, Coronado AR, Marquez RC, Chen H, Wei P, Savage MI, Vornik LA, Fox JT, Sei S, Liang D, Stevenson HL, Wilkerson GK, Gagea M, Brown PH, Beretta L. Treatment strategies and mechanisms associated with the prevention of NASH-associated HCC by a toll-like receptor 4 inhibitor. Cancer Prev Res (Phila) 16(1):17-28, 2023. e-Pub 2023. PMID: 36162136.
15. Barsoumian HB, Sheth RA, Ramapriyan R, Hsu E, Gagea M, Crowley K, Sezen D, Williams M, Welsh JW. Radiation Therapy Modulates Tumor Physical Characteristics to Reduce Intratumoral Pressure and Enhance Intratumoral Drug Delivery and Retention. Adv Radiat Oncol 8(2):101137, 2023. e-Pub 2023. PMID: 36632088.
16. Aslan B, Kismali G, Iles LR, Manyam GC, Ayres ML, Chen LS, Gagea M, Bertilaccio MTS, Wierda WG, Gandhi V. Pirtobrutinib inhibits wild-type and mutant Bruton's tyrosine kinase-mediated signaling in chronic lymphocytic leukemia. Blood Cancer J 12(5):80, 2022. e-Pub 2022. PMID: 35595730.
17. Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, Pandey R, Skwarska A, Patel S, Tremblay M, Kuruvilla VM, Cavazos A, Kaplan M, Warmoes MO, Veiga DT, Furudate K, Rojas-Sutterin S, Haman A, Gareau Y, Marinier A, Ma H, Harutyunyan K, Daher M, Garcia LM, Al-Atrash G, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, Gay J, Du D, Yang JJ, Hoff FW, Kaminski M, Tomczak K, Eric Davis R, Herranz D, Ferrando A, Jabbour EJ, Emilia Di Francesco M, Teachey DT, Horton TM, Kornblau S, Rezvani K, Sauvageau G, Gagea M, Andreeff M, Takahashi K, Marszalek JR, Lorenzi PL, Yu J, Tiziani S, Hoang T, Konopleva M. Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia. Nat Commun 13(1):2801, 2022. e-Pub 2022. PMID: 35589701.
18. Liu Y, Deguchi Y, Wei D, Liu F, Moussalli MJ, Deguchi E, Li D, Wang H, Valentin LA, Colby JK, Wang J, Zheng X, Ying H, Gagea M, Ji B, Shi J, Yao JC, Zuo X, Shureiqi I. Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. Nat Commun 13(1):2665, 2022. e-Pub 2022. PMID: 35562376.
19. Steers NJ, Gupta Y, D'Agati VD, Lim TY, DeMaria N, Mo A, Liang J, Stevens KO, Ahram DF, Lam WY, Gagea M, Nagarajan L, Sanna-Cherchi S, Gharavi AG. GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus. J Am Soc Nephrol 33(1):108-120, 2022. e-Pub 2022. PMID: 34893534.
20. Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC. Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun 12(1):5389, 2021. e-Pub 2021. PMID: 34508101.
21. Hachem R, Parikh UM, Reitzel R, Rosenblatt J, Kaul A, Vargas-Cruz N, Hill L, Moore L, Meyer J, Chaftari AM, Gagea M, Balaji S, Raad II. Novel antimicrobial ointment for infected wound healing in an in vitro and in vivo porcine model. Wound Repair Regen 29(5):830-842, 2021. e-Pub 2021. PMID: 33956391.
22. Aslan B, Kismali G, Chen LS, Iles LR, Mahendra M, Peoples M, Gagea M, Fowlkes NW, Zheng X, Wang J, Vellano CP, Marszalek JR, Bertilaccio MTS, Gandhi V. Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL. Blood Adv 5(16):3134-3146, 2021. e-Pub 2021. PMID: 34424317.
23. Piotrowski SL, Gagea M, Huang SY, Shetty G, Hill LR. Pathology in Practice. J Am Vet Med Assoc 258(2):161-164, 2021. e-Pub 2021. PMID: 33405981.
24. Al-Hassan JM, Wei D, Chakraborty S, Conway T, Rhea P, Wei B, Tran M, Gagea M, Afzal M, Oommen S, Nair D, Paul BM, Yang P. Fraction B From Catfish Epidermal Secretions Kills Pancreatic Cancer Cells, Inhibits CD44 Expression and Stemness, and Alters Cancer Cell Metabolism. Front Pharmacol 12:659590, 2021. e-Pub 2021. PMID: 34349642.
25. Mendt M, Daher M, Basar R, Shanley M, Kumar B, Wei Inng FL, Acharya S, Shaim H, Fowlkes N, Tran JP, Gokdemir E, Uprety N, Nunez-Cortes AK, Ensley E, Mai T, Kerbauy LN, Melo-Garcia L, Lin P, Shen Y, Mohanty V, Lu J, Li S, Nandivada V, Wang J, Banerjee P, Reyes-Silva F, Liu E, Ang S, Gilbert A, Li Y, Wan X, Gu J, Zhao M, Baran N, Muniz-Feliciano L, Wilson J, Kaur I, Gagea M, Konopleva M, Marin D, Tang G, Chen K, Champlin R, Rezvani K, Shpall EJ. Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD. Front Immunol 12:631353, 2021. e-Pub 2021. PMID: 34017325.
26. Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, Cruz De Los Santos M, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA. The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. Gastroenterology 159(6):2146-2162.e33, 2020. e-Pub 2020. PMID: 32805281.
27. Davis JS, Kanikarla-Marie P, Gagea M, Yu PL, Fang D, Sebastian M, Yang P, Hawk E, Dashwood R, Lichtenberger LM, Menter D, Kopetz S. Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development. BMC Cancer 20(1):871, 2020. e-Pub 2020. PMID: 32912193.
28. Yang P, Rhea PR, Conway T, Nookala S, Hegde V, Gagea M, Ajami NJ, Harribance SL, Ochoa J, Sastry JK, Cohen L. Human Biofield Therapy Modulates Tumor Microenvironment and Cancer Stemness in Mouse Lung Carcinoma. Integr Cancer Ther 19:1534735420940398, 2020. e-Pub 2020. PMID: 32975128.
29. Tandon N, Goller K, Wang F, Soibam B, Gagea M, Jain AK, Schwartz RJ, Liu Y. Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis. EBioMedicine 50:55-66, 2019. e-Pub 2019. PMID: 31761621.
30. Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I. PPARD and Interferon gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice. Gastroenterology 157(1):163-178, 2019. e-Pub 2019. PMID: 30885780.
31. Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, Xu W, Xu M, Liu F, Gao S, Jaoude JC, Chrieki SP, Moussalli MJ, Gagea M, Morris J, Broaddus RR, Zuo X, Shureiqi I. Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. Cancer Res 79(5):954-969, 2019. e-Pub 2019. PMID: 30679176.
32. Liu S, Li S, Wang B, Liu W, Gagea M, Chen H, Sohn J, Parinyanitikul N, Primeau T, Do KA, Vande Woude GF, Mendelsohn J, Ueno NT, Mills GB, Tripathy D, Gonzalez-Angulo AM. Cooperative effect of oncogenic MET and PIK3CA in an HGF-dominant environment in breast cancer. Mol Cancer Ther 18(2):399-412, 2019. e-Pub 2019. PMID: 30518672.
33. Yang P, Jiang Y, Rhea PR, Coway T, Chen D, Gagea M, Harribance SL, Cohen L. Human Biofield Therapy and the Growth of Mouse Lung Carcinoma. Integr Cancer Ther 18:1534735419840797, 2019. e-Pub 2019. PMID: 30947564.
34. Debiane L, Reitzel R, Rosenblatt J, Gagea M, Chavez MA, Adachi R, Grosu HB, Sheshadri A, Hill LR, Raad I, Ost DE. A Design-Based Stereologic Method to Quantify the Tissue Changes Associated with a Novel Drug-Eluting Tracheobronchial Stent. Respiration 98(1):60-69, 2019. e-Pub 2019. PMID: 30799409.
35. Mendt M, Kamerkar S, Sugimoto H, McAndrews KM, Wu CC, Gagea M, Yang S, Blanko EVR, Peng Q, Ma X, Marszalek JR, Maitra A, Yee C, Rezvani K, Shpall E, LeBleu VS, Kalluri R. Generation and testing of clinical-grade exosomes for pancreatic cancer. JCI Insight 3(8), 2018. e-Pub 2018. PMID: 29669940.
36. Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res 28(4):432-447, 2018. e-Pub 2018. PMID: 29567676.
37. Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG. MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. Proc Natl Acad Sci U S A 115(11):2806-2811, 2018. e-Pub 2018. PMID: 29490919.
38. Liu E, Tong Y, Dotti G, Shaim H, Savoldo B, Mukherjee M, Orange J, Wan X, Lu X, Reynolds A, Gagea M, Banerjee P, Cai R, Bdaiwi MH, Basar R, Muftuoglu M, Li L, Marin D, Wierda W, Keating M, Champlin R, Shpall E, Rezvani K. Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity. Leukemia 32(2):520-531, 2018. e-Pub 2018. PMID: 28725044.
39. Parikh N, Shuck RL, Gagea M, Shen L, Donehower LA. Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice. Aging Cell 17(1), 2018. e-Pub 2018. PMID: 29047229.
40. Smith, B, Hsu, Y, Flores, R, Gagea Iurascu, M, Craig, S, Hung, M. Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy. American Journal of Cancer Research 8(1):183-191, 2018. e-Pub 2018.
41. Melancon MP, Appleton Figueira T, Fuentes DT, Tian L, Qiao Y, Gu J, Gagea M, Ensor JE, Muñoz NM, Maldonado KL, Dixon K, McWatters A, Mitchell J, McArthur M, Gupta S, Tam AL. Development of an Electroporation and Nanoparticle-based Therapeutic Platform for Bone Metastases. Radiology 286(1):149-157, 2018. e-Pub 2018. PMID: 28825892.
42. Jiao J, Á G, Stevenson HL, Gagea M, Sugimoto H, Kalluri R, Beretta L. Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors. Exp Mol Med 50(1):e422, 2018. e-Pub 2018. PMID: 29303514.
43. Dibra D, Xia X, Gagea M, Lozano G, Li S. A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. PLoS One 13(3):e0193485, 2018. e-Pub 2018. PMID: 29494633.
44. Wang L, Gagea M, Martirosyan K, Johansen M, Madden T, Norberg L, Culotta KS, Frank SJ. Toxicity Evaluation of a Novel Magnetic Resonance Imaging Marker, CoCl2-N-Acetylcysteine, in Rats. J Toxicol 2018:9173452, 2018. e-Pub 2018. PMID: 30631353.
45. Smith B, Hsu YH, Flores R, Gagea M, Craig S, Hung MC. Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy. Am J Cancer Res 8(1):183-191, 2018. e-Pub 2018. PMID: 29416931.
46. Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Gomez JE, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z. TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p. Nat Commun 8(1):947, 2017. e-Pub 2017. PMID: 29038531.
47. Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi X. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun 8(1):1088, 2017. e-Pub 2017. PMID: 29057918.
48. Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U, Tweardy DJ, Beretta L. Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice. Clin Cancer Res 23(18):5537-5546, 2017. e-Pub 2017. PMID: 28533225.
49. Wang C, Gu C, Jeong KJ, Zhang D, Guo W, Lu Y, Ju Z, Panupinthu N, Yang JY, Gagea MM, Ng PK, Zhang F, Mills GB. YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway. Cancer Res 77(7):1637-1648, 2017. e-Pub 2017. PMID: 28202507.
50. Federico L, Chong Z, Zhang D, McGrail DJ, Zhao W, Jeong KJ, Vellano CP, Ju Z, Gagea M, Liu S, Mitra S, Dennison JB, Lorenzi PL, Cardnell R, Diao L, Wang J, Lu Y, Byers LA, Perou CM, Lin SY, Mills GB. A murine preclinical syngeneic transplantation model for breast cancer precision medicine. Sci Adv 3(4):e1600957, 2017. e-Pub 2017. PMID: 28439535.
51. Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, Wei D, Hung MC, Sood AK, Shureiqi I. Metastasis regulation by PPARD expression in cancer cells. JCI Insight 2(1):e91419, 2017. e-Pub 2017. PMID: 28097239.
52. Kim J, de Sampaio PC, Lundy DM, Peng Q, Evans KW, Sugimoto H, Gagea M, Kienast Y, do Amaral NS, Rocha RM, Eikesdal HP, Lønning PE, Meric-Bernstam F, LeBleu VS. Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. JCI Insight 1(21):e90733, 2016. e-Pub 2016. PMID: 28018977.
53. Tam AL, Figueira TA, Gagea M, Ensor JE, Dixon K, McWatters A, Gupta S, Fuentes DT. Irreversible Electroporation in the Epidural Space of the Porcine Spine: Effects on Adjacent Structures. Radiology 281(3):152688, 2016. e-Pub 2016. PMID: 27266723.
54. Treekitkarnmongkol W, Katayama H, Kai K, Sasai K, Jones JC, Wang J, Shen L, Sahin AA, Gagea M, Ueno NT, Creighton CJ, Sen S. Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer. Carcinogenesis 37(12):1180-1189, 2016. e-Pub 2016. PMID: 27624071.
55. Belousova N, Mikheeva G, Xiong C, Stagg LJ, Gagea M, Fox PS, Bassett RL, Ladbury JE, Braun MB, Stehle T, Li C, Krasnykh V. Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. Oncotarget 7(33):53414-53429, 2016. e-Pub 2016. PMID: 27462785.
56. Georgescu MM, Gagea M, Cote G. NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia. Neoplasia 18(8):512-23, 2016. e-Pub 2016. PMID: 27566107.
57. Dibra D, Mitra A, Newman M, Xia X, Cutrera JJ, Gagea M, Kleinerman ES, Lozano G, Li S. Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo. Clin Cancer Res 22(15):3876-83, 2016. e-Pub 2016. PMID: 26979394.
58. Sergeeva A, He H, Ruisaard K, St John L, Alatrash G, Clise-Dwyer K, Li D, Patenia R, Hong R, Sukhumalchandra P, You MJ, Gagea M, Ma Q, Molldrem JJ. Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo. Leukemia 30(7):1475-84, 2016. e-Pub 2016. PMID: 27055866.
59. Yan J, Mitra A, Hu J, Cutrera JJ, Xia X, Doetschman T, Gagea M, Mishra L, Li S. Corrigendum to "Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells". J Hepatol. e-Pub 2016. PMID: 27241198.
60. Yan J, Mitra A, Hu J, Cutrera JJ, Xia X, Doetschman T, Gagea M, Mishra L, Li S. Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. J Hepatol 64(5):1128-36, 2016. e-Pub 2016. PMID: 26767500.
61. Koh MY, Gagea M, Sargis T, Lemos R, Grandjean G, Charbono A, Bekiaris V, Sedy J, Kiriakova G, Liu X, Roberts LR, Ware C, Powis G. A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Hepatology 63(5):1576-91, 2016. e-Pub 2016. PMID: 26799785.
62. Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene 35(17):2186-96, 2016. e-Pub 2016. PMID: 26212011.
63. Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K. KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. Cancer Res 76(8):2419-31, 2016. e-Pub 2016. PMID: 26880805.
64. Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell 29(3):324-38, 2016. e-Pub 2016. PMID: 26977883.
65. Jung KH, Zhang J, Zhou C, Shen H, Gagea M, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Beretta L. Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis. Hepatology 63(3):864-79, 2016. e-Pub 2016. PMID: 26599259.
66. Jiang Y, Pan Y, Rhea PR, Tan L, Gagea M, Cohen L, Fischer SM, Yang P. A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway. Cancer Res 76(1):24-9, 2016. e-Pub 2016. PMID: 26729790.
67. Hill LR, Huang SY, Gagea M. Diaphragmatic Hernia of the Stomach with Gastric Rupture in a Domestic Pig. Comp Med 66(5):399-404, 2016. e-Pub 2016. PMID: 27780007.
68. Davis JS, Gupta V, Gagea M, Wu X. An Advanced Histologic Method for Evaluation of Intestinal Adenomas in Mice Using Digital Slides. PLoS One 11(3):e0151463, 2016. e-Pub 2016. PMID: 26974326.
69. McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. Correction: Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes. PLoS One 11(3):e0151121, 2016. e-Pub 2016. PMID: 26953790.
70. Pan Y, Jiang Y, Tan L, Ravoori MK, Gagea M, Kundra V, Fischer SM, Yang P. Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis. Oncotarget 6(36):38816-26, 2015. e-Pub 2015. PMID: 26452035.
71. Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee Iv GR, Lin CC, Gagea M, Marti AA, Ladbury JE. Corrigendum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nat Commun 6:8007, 2015. e-Pub 2015. PMID: 26234419.
72. Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee GR, Lin CC, Gagea M, Marti AA, Ladbury JE. Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nat Commun 6:7354, 2015. e-Pub 2015. PMID: 26103942.
73. Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC. TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene 34(22):2836-45, 2015. e-Pub 2015. PMID: 25065590.
74. Zhang J, Jiao J, Cermelli S, Muir K, Jung KH, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L. miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Res 75(9):1859-67, 2015. e-Pub 2015. PMID: 25769721.
75. Pan Y, Rhea P, Tan L, Cartwright C, Lee HJ, Ravoori MK, Addington C, Gagea M, Kundra V, Kim SJ, Newman RA, Yang P. PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway. Invest New Drugs 33(2):271-9, 2015. e-Pub 2015. PMID: 25476893.
76. Liu S, Meric-Bernstam F, Parinyanitikul N, Wang B, Eterovic AK, Zheng X, Gagea M, Chavez-MacGregor M, Ueno NT, Lei X, Zhou W, Nair L, Tripathy D, Brown PH, Hortobagyi GN, Chen K, Mendelsohn J, Mills GB, Gonzalez-Angulo AM. Functional consequence of the MET-T1010I polymorphism in breast cancer. Oncotarget 6(5):2604-14, 2015. e-Pub 2015. PMID: 25605252.
77. Henderson YC, Ahn SH, Ryu J, Chen Y, Williams MD, El-Naggar AK, Gagea M, Schweppe RE, Haugen BR, Lai SY, Clayman GL. Development and Characterization of Six New Human Papillary Thyroid Carcinoma Cell Lines. J Clin Endocrinol Metab 100(2):jc20142624, 2015. e-Pub 2015. PMID: 25427145.
78. Jiang S, Minter LC, Stratton SA, Yang P, Abbas HA, Akdemir ZC, Pant V, Post S, Gagea M, Lee RG, Lozano G, Barton MC. TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. J Hepatol 62(2):371-9, 2015. e-Pub 2015. PMID: 25281858.
79. Timsah, ZS, Berrout, J, Suraokar, M, Behrens, MC, Song, J, Lee, JJ, Ivan, C, Gagea Iurascu, M, Shires, M, Hu, X, Vallien, C, Kingsley, CV, Wistuba, II, Ladbury, JD. Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma. American Journal of Cancer Research 5(10):3135-3148, 2015. e-Pub 2015.
80. McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes. PLoS One 10(9):e0136851, 2015. e-Pub 2015. PMID: 26325287.
81. Timsah Z, Berrout J, Suraokar M, Behrens C, Song J, Lee JJ, Ivan C, Gagea M, Shires M, Hu X, Vallien C, Kingsley CV, Wistuba I, Ladbury JE. Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma. Am J Cancer Res 5(10):3135-48, 2015. e-Pub 2015. PMID: 26693065.
82. Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB. Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers. Cancer Cell 26(6):863-79, 2014. e-Pub 2014. PMID: 25490449.
83. Mitra A, Satelli A, Yan J, Xueqing X, Gagea M, Hunter CA, Mishra L, Li S. IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice. Hepatology 60(6):2027-39, 2014. e-Pub 2014. PMID: 25351459.
84. Liu S, Meng X, Chen H, Liu W, Miller T, Murph M, Lu Y, Zhang F, Gagea M, Arteaga CL, Mills GB, Meric-Bernstam F, González-Angulo AM. Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer. Oncotarget 5(19):9049-64, 2014. e-Pub 2014. PMID: 24979294.
85. Muñoz NM, Katz LH, Shina JH, Gi YJ, Menon VK, Gagea M, Rashid A, Chen J, Mishra L. Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption. Genes Cancer 5(9-10):348-52, 2014. e-Pub 2014. PMID: 25352951.
86. Tam AL, Abdelsalam ME, Gagea M, Ensor JE, Moussa M, Ahmed M, Goldberg SN, Dixon K, McWatters A, Miller JJ, Srimathveeravalli G, Solomon SB, Avritscher R, Wallace MJ, Gupta S. Irreversible Electroporation of the Lumbar Vertebrae in a Porcine Model: Is There Clinical-Pathologic Evidence of Neural Toxicity?. Radiology 272(3):132560, 2014. e-Pub 2014. PMID: 24766034.
87. Panupinthu N, Yu S, Zhang D, Zhang F, Gagea M, Lu Y, Grandis JR, Dunn SE, Lee HY, Mills GB. Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer. Oncogene 33(22):2846-56, 2014. e-Pub 2014. PMID: 23851501.
88. Zuo X, Xu M, Yu J, Wu Y, Moussalli MJ, Manyam GC, Lee SI, Liang S, Gagea M, Morris JS, Broaddus RR, Shureiqi I. Potentiation of Colon Cancer Susceptibility in Mice by Colonic Epithelial PPAR-δ/β Overexpression. J Natl Cancer Inst 106(4):dju052, 2014. e-Pub 2014. PMID: 24681603.
89. Agarwal NK, Zhu X, Gagea M, White CL, Cote G, Georgescu MM. PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase. Oncotarget 5(3):815-23, 2014. e-Pub 2014. PMID: 24553260.
90. Munoz, NM, Katz, L, Shin, J, Gi, YJ, Menon, VK, Gagea Iurascu, M, Rashid, A, Chen, J, Mishra, L. Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption. Genes and Cancer 5(9-10):348-352, 2014. e-Pub 2014.
91. Frank SJ, Johansen MJ, Martirosyan KS, Gagea M, Van Pelt CS, Borne A, Carmazzi Y, Madden T. A Biodistribution and Toxicity Study of Cobalt Dichloride-N-Acetyl Cysteine in an Implantable MRI Marker for Prostate Cancer Treatment. Int J Radiat Oncol Biol Phys 85(4):1024-30, 2013. e-Pub 2013. PMID: 23092727.
92. Uthamanthil RK, Hachem RY, Gagea M, Reitzel RA, Borne AT, Tinkey PT. Urinary catheterization of male rabbits: a new technique and a review of urogenital anatomy. J Am Assoc Lab Anim Sci 52(2):180-5, 2013. e-Pub 2013. PMID: 23562102.
93. Zhu X, Morales FC, Agarwal NK, Dogruluk T, Gagea M, Georgescu MM. Moesin is a glioma progression marker that induces proliferation and Wnt/β-catenin pathway activation via interaction with CD44. Cancer Res 73(3):1142-55, 2013. e-Pub 2013. PMID: 23221384.
94. Ravoori M, Duggal J, Gagea M, Han L, Singh S, Liu P, Wei W, Ragan DK, Bankson JA, Ma J, Kundra V. Visualizing the prostate gland by MR imaging in young and old mice. PLoS One 8(3):e55746, 2013. e-Pub 2013. PMID: 23469167.
95. Liang ZD, Long Y, Tsai WB, Fu S, Kurzrock R, Gagea-Iurascu M, Zhang F, Chen HH, Hennessy BT, Mills GB, Savaraj N, Kuo MT. Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther 11(11):2483-94, 2012. e-Pub 2012. PMID: 22914438.
96. Di Domizio J, Dorta-Estremera S, Gagea M, Ganguly D, Meller S, Li P, Zhao B, Tan FK, Bi L, Gilliet M, Cao W. Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity. Proc Natl Acad Sci U S A 109(36):14550-5, 2012. e-Pub 2012. PMID: 22904191.
97. Di Domizio J, Zhang R, Stagg LJ, Gagea M, Zhuo M, Ladbury JE, Cao W. Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid. J Biol Chem 287(1):736-47, 2012. e-Pub 2012. PMID: 22102410.
98. Avritscher R, Wright KC, Javadi S, Uthamanthil R, Gupta S, Gagea M, Bassett RL, Murthy R, Wallace MJ, Madoff DC. Development of a Large Animal Model of Cirrhosis and Portal Hypertension Using Hepatic Transarterial Embolization: A study in swine. J Vasc Interv Radiol 22(9):1329-34, 2011. e-Pub 2011. PMID: 21802316.
99. Ochoa CE, Mirabolfathinejad SG, Ruiz VA, Evans SE, Gagea M, Evans CM, Dickey BF, Moghaddam SJ. Interleukin 6 But Not T Helper 2 Cytokines Promotes Lung Carcinogenesis. Cancer Prev Res (Phila) 4(1):51-64, 2011. e-Pub 2011. PMID: 21098042.
100. Gagea MI, Bateman KG, Shanahan RA, van Dreumel T, McEwen BJ, Carman S, Archambault M, Caswell JL. Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves. J Vet Diagn Invest 18(1):29-40, 2006. e-Pub 2006. PMID: 16566255.
101. Gagea MI, Bateman KG, van Dreumel T, McEwen BJ, Carman S, Archambault M, Shanahan RA, Caswell JL. Diseases and pathogens associated with mortality in Ontario beef feedlots. J Vet Diagn Invest 18(1):18-28, 2006. e-Pub 2006. PMID: 16566254.
102. Wellehan JF, Gagea M, Smith DA, Taylor WM, Berhane Y, Bienzle D. Characterization of a herpesvirus associated with tracheitis in Gouldian finches (Erythrura [Chloebia] gouldiae). J Clin Microbiol 41(9):4054-7, 2003. e-Pub 2003. PMID: 12958225.

Other Articles

1. Tan RH, Crisman MV, Clark SP, Gagea M, Zimmerman K Multicentric mastocytoma in a horse. J Vet Intern Med 21(2):340-3, 2007. PMID: 17427399.

Abstracts

1. Baran N, Lodi A, Dhungana Y, Sweeney S, Pandey R, Herbrich S, Hof FW, Skwarska A, Kaplan M, Kuruvilla VM, Cavazos A, Ma H, Warmoes M, Veiga DT, Rojas-Sutterin S, Haman A, Harutyunyan K, Daher M, Garcia LM, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, Gay J, Du5 D, Yang JJ, Tomczak K, Kaminski M, Davis E, Herranz D, Ferrando A, Jabbour EJ, M Emilia Di Francesco M, Teachey DT, Horton TM, Rezvani K, Kornblau S, Iurascu MG, Takahashi K, Andreeff M, Marszalek JR, Lorenzi PL, Yu J, Tiziani S, Hoang T, Konopleva M. Overcoming NOTCH1-driven chemoresistance in T-cell acute lymphoblastic leukemia via metabolic intervention with OxPhos inhibitor.

Book Chapters

1. Gagea Iurascu, M, Craig, S. Euthanasia and Necropsy, 117-139, 2012.
2. Gagea-Iurascu M, Craig S. Euthanasia and Necropsy. In: The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. First edition. Academic Press, Elsevier, 1268, 2012.

Letters to the Editor

1. Zuo X, Wang L, Liu Y, Wang H, Hafley M, Gagea M, Chen R, Xiong Y, Pan S, Shureiqi I, Bresalier RS, Wei D. Dysregulated KLF4 expression plays a pivotal role in the pathogenesis of pancreatic intraductal papillary mucinous neoplasms. Gut 74: 327-329, 2025.