Niki M. Zacharias Millward, PhD
Department of Urology, Division of Surgery
About Dr. Niki M. Zacharias Millward
Rewiring of cellular metabolism is a hallmark of cancer. Metabolism fuels cellular growth and proliferation and is downstream of genomic, transcriptomic, and proteomic changes. Our lab wants to understand the metabolic changes that drive cancer progression, how these changes create therapeutic vulnerabilities, and how metabolic imaging can be used to monitor therapeutic response. The Department of Urology at MD Anderson often treats patients with rare urological cancers such as penile cancer, renal medullary carcinoma, chromophobe renal cell cancer, and fumarate-hydratase deficient renal cell carcinoma. Our lab has generated some of the only patient-derived xenograft (PDX) animal models of these rare cancers which provides a powerful tool for understanding these subtypes and developing new, targeted therapeutic modalities for their treatment. Our discoveries in these models can be further complemented and validated using our deep bank of patient tissues. My goal is to create an integrated platform that generates animal models of rare urological cancers from patient tissue, carries out molecular analysis of these models to inform new therapeutic development, cross-validates these observations with banked patient tissues, and uses the resulting data to develop new clinical trials.
Present Title & Affiliation
Primary Appointment
Associate Member, University of Texas Graduate School of Biomedical Sciences, Houston, TX
Associate Professor, Department of Urology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Assistant Professor, Department of Urology - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
James G. Boswell Fellow, Division of Diagnostic Imaging, Huntington Medical Research Institutes and California Institute of Technology, Pasadena, CA
Education & Training
Degree-Granting Education
| 2004 | California Institute of Technology, Pasadena, CA, USA, PHD, Chemistry |
| 1997 | Texas A&M University, College Station, TX, USA, BS, Chemistry |
Experience & Service
Academic Appointments
Assistant Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2017
Other Appointments/Responsibilities
Scientist II, Neurion Pharmaceuticals, Pasadena, CA, 2004 - 2007
Honors & Awards
| 2011 | Best Poster and Presentation Award in MRI Probes including Hyperpolarization II Session at World Molecular Imaging Congress |
| 2011 | International Society of Magnetic Resonance Annual Research Conference Student Stipend Award |
| 2010 | In Vivo Magnetic Resonance Gordon Research Conference Student Stipend Award |
| 2000 | NIH Training Grant in Bioorganic Chemistry |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Rose KM, Pham R, Zacharias NM, Ionescu F, Paravathaneni M, Marchetti KA, Sanchez D, Mustasam A, Sandstrom R, Vikram R, Dhillon J, Rao P, Schneider A, Pagliaro L, Alifrangis C, Albersen M, Roussel E, Master VA, Nazha B, Hernandez C, Moses KA, Protzel C, Montgomery J, Angel M, Tobias-Machado M, Spiess PE, Pettaway CA, Chahoud J. Neoadjuvant Platinum-Based chemotherapy and lymphadenectomy for penile cancer: an international, Multi-Institutional, Real-World study. J Natl Cancer Inst 116(6):966-973, 2024. e-Pub 2024. PMID: 38366627.
- Zacharias NM, Segarra L, Akagi K, Fowlkes NW, Chen H, Alaniz A, de la Cerda C, Pesquera P, Xi Y, Wang J, Chahoud J, Lu X, Rao P, Martinez-Ferrer M, Pettaway CA. Transcriptomic, Proteomic, and Genomic Mutational Fraction Differences Based on HPV Status Observed in Patient-Derived Xenograft Models of Penile Squamous Cell Carcinoma. Cancers (Basel) 16(5), 2024. e-Pub 2024. PMID: 38473423.
- Ionescu F, Nguyen J, Segura CM, Paravathaneni M, Grass GD, Johnstone P, Zacharias NM, Pettaway CA, Lu X, Kim Y, Whiting J, Dhillon J, Eschrich SA, Chadha J, Gullapalli K, Roman Souza G, Miyagi H, Manley BJ, Spiess PE, Chahoud J. Multiplex Immunofluorescence Captures Progressive Immune Exhaustion with Advancing Penile Squamous Cell Cancer Stage. Cancers (Basel) 16(2), 2024. e-Pub 2024. PMID: 38275860.
- Parza K, Mustasam A, Ionescu F, Paravathaneni M, Sandstrom R, Safa H, Grass GD, Johnstone PA, Eschrich SA, Chadha J, Zacharias N, Pettaway CA, Spiess PE, Chahoud J. The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma-A Systematic Review. Cancers (Basel) 15(14), 2023. e-Pub 2023. PMID: 37509374.
- Shapiro DD, Zacharias NM, Tripathi DN, Karki M, Bertocchio JP, Soeung M, He R, Westerman ME, Gao J, Rao P, Lam TNA, Jonasch E, Perelli L, Cheng EH, Carugo A, Heffernan TP, Walker CL, Genovese G, Tannir NM, Karam JA, Msaouel P. Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy. Clin Transl Med 13(5):e1267, 2023. PMID: 37226898.
- Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G. SMARCB1 regulates the hypoxic stress response in sickle cell trait. Proc Natl Acad Sci U S A 120(21):e2209639120, 2023. e-Pub 2023. PMID: 37186844.
- Tu SM, Moran C, Norton W, Zacharias NM. Stem Cell Theory of Cancer: Origin of Metastasis and Sub-clonality. Semin Diagn Pathol 40(1):63-68, 2023. e-Pub 2022. PMID: 35729019.
- Pollard AC, Paolillo V, Radaram B, Qureshy S, Li L, Maity T, Wang L, Uddin MN, Wood CG, Karam JA, Pagel MD, Piwnica-Worms D, Millward SW, Fowlkes NW, Norton W, Engel BJ, Pisaneschi F, Zacharias NM. PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine. Mol Imaging Biol 24(6):959-972, 2022. e-Pub 2022. PMID: 35732988.
- Chahoud J, Zacharias NM, Pham R, Qiao W, Guo M, Lu X, Alaniz A, Segarra L, Martinez-Ferrer M, Gleber-Netto FO, Pickering CR, Rao P, Pettaway CA. Prognostic Significance of p16 and Its Relationship with Human Papillomavirus Status in Patients with Penile Squamous Cell Carcinoma: Results of 5 Years Follow-Up. Cancers (Basel) 14(24), 2022. e-Pub 2022. PMID: 36551510.
- Pieretti AC, Ozambela M, Westerman ME, Nogueras-Gonzalez GM, Segarra LA, Zacharias NM, Vaporciyan A, Hofstetter W, Huynh T, Aldousari S, Matin SF, Karam JA. Predictors of Survival in Patients Undergoing Surgery for Renal Cell Carcinoma and Inferior Vena Cava Tumor Thrombus. Clin Genitourin Cancer 20(4):e330-e338, 2022. e-Pub 2022. PMID: 35279419.
- Grindel BJ, Engel BJ, Ong JN, Srinivasamani A, Liang X, Zacharias NM, Bast RC, Curran MA, Takahashi TT, Roberts RW, Millward SW. Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display. ACS Chem Biol 17(6):1543-1555, 2022. e-Pub 2022. PMID: 35611948.
- Tu SM, Guo CC, Chow DS, Zacharias NM. Stem Cell Theory of Cancer: Implications for Drug Resistance and Chemosensitivity in Cancer Care. Cancers (Basel) 14(6), 2022. e-Pub 2022. PMID: 35326699.
- McCowan CV, Salmon D, Hu J, Pudakalakatti S, Whiting N, Davis JS, Carson DD, Zacharias NM, Bhattacharya PK, Farach-Carson MC. Post-Acquisition Hyperpolarized 29Silicon Magnetic Resonance Image Processing for Visualization of Colorectal Lesions Using a User-Friendly Graphical Interface. Diagnostics (Basel) 12(3), 2022. e-Pub 2022. PMID: 35328163.
- Pudakalakatti S, Titus M, Enriquez JS, Ramachandran S, Zacharias NM, Shureiqi I, Liu Y, Yao JC, Zuo X, Bhattacharya PK. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Int J Mol Sci 23(3), 2022. e-Pub 2022. PMID: 35163565.
- Tu SM, Estecio MR, Lin SH, Zacharias NM. Stem Cell Theory of Cancer: Rude Awakening or Bad Dream from Cancer Dormancy?. Cancers (Basel) 14(3), 2022. e-Pub 2022. PMID: 35158923.
- Pieretti AC, Westerman ME, Childs A, Millward N, Shapiro DD, Sircar K, Rao P, Jonasch E, Campbell MT, Tannir NM, Matin SF, Wood CG, Karam JA. Sarcomatoid features and lymph node-positive disease in chromophobe renal cell carcinoma. Urol Oncol 39(11):790.e17-790.e23, 2021. e-Pub 2021. PMID: 34301458.
- Pudakalakatti S, Enriquez JS, McCowan C, Ramezani S, Davis JS, Zacharias NM, Bourgeois D, Constantinou PE, Harrington DA, Carson D, Farach-Carson MC, Bhattacharya PK. Hyperpolarized MRI with silicon micro and nanoparticles: Principles and applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13(6):e1722, 2021. e-Pub 2021. PMID: 33982426.
- Salzillo TC, Mawoneke V, Weygand J, Shetty A, Gumin J, Zacharias NM, Gammon ST, Piwnica-Worms D, Fuller GN, Logothetis CJ, Lang FF, Bhattacharya PK. Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance. Cells 10(10), 2021. e-Pub 2021. PMID: 34685601.
- Enriquez JS, Chu Y, Pudakalakatti S, Hsieh KL, Salmon D, Dutta P, Millward NZ, Lurie E, Millward S, McAllister F, Maitra A, Sen S, Killary A, Zhang J, Jiang X, Bhattacharya PK, Shams S. Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer. JMIR Med Inform 9(6):e26601, 2021. e-Pub 2021. PMID: 34137725.
- Zacharias NM, Wang L, Maity T, Li L, Millward SW, Karam JA, Wood CG, Navai N. Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo. Int J Mol Sci 22(6), 2021. e-Pub 2021. PMID: 33799686.
- Rao Y, Gammon S, Zacharias NM, Liu T, Salzillo T, Xi Y, Wang J, Bhattacharya P, Piwnica-Worms D. Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane. Proc Natl Acad Sci U S A 117(36):22378-22389, 2020. e-Pub 2020. PMID: 32839325.
- Dutta P, Pando SC, Mascaro M, Riquelme E, Zoltan M, Zacharias NM, Gammon ST, Piwnica-Worms D, Pagel MD, Sen S, Maitra A, Shams S, McAllister F, Bhattacharya PK. Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy. Int J Mol Sci 21(10), 2020. e-Pub 2020. PMID: 32466260.
- Zacharias NM, Baran N, Shanmugavelandy SS, Lee J, Velez Lujan J, Dutta P, Millward SW, Cai T, Wood CG, Piwnica-Worms D, Konopleva M, Bhattacharya PK. Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia. Mol Cancer Ther. e-Pub 2019. PMID: 31387889.
- Yang H, Shu Z, Jiang Y, Mao W, Pang L, Redwood A, Jeter-Jones SL, Jennings NB, Ornelas A, Zhou J, Rodriguez-Aguayo C, Bartholomeusz G, Iles LR, Zacharias NM, Millward SW, Lopez-Berestein G, Le XF, Ahmed AA, Piwnica-Worms H, Sood AK, Bast RC, Lu Z. 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers. Clin Cancer Res. e-Pub 2019. PMID: 31391192.
- Dutta P, Perez MR, Lee J, Kang Y, Pratt M, Salzillo TC, Weygand J, Zacharias NM, Gammon ST, Koay EJ, Kim M, McAllister F, Sen S, Maitra A, Piwnica-Worms D, Fleming JB, Bhattacharya PK. Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer. J Proteome Res 18(7):2826-2834, 2019. e-Pub 2019. PMID: 31120258.
- Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM, Bhattacharya PK. Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells 8(4), 2019. e-Pub 2019. PMID: 30978984.
- Zacharias NM, Ornelas A, Lee J, Hu J, Davis JS, Uddin N, Pudakalakatti S, Menter DG, Karam JA, Wood CG, Hawk ET, Kopetz S, Vilar E, Bhattacharya PK, Millward SW. Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy. Angew Chem Int Ed Engl 58(13):4179-4183, 2019. e-Pub 2019. PMID: 30680862.
- Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA, Bhattacharya P. Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo. Mol Imaging Biol 21(1):86-94, 2019. e-Pub 2018. PMID: 29748904.
- Seo H, Choi I, Whiting N, Hu J, Luu QS, Pudakalakatti S, McCowan C, Kim Y, Zacharias N, Lee S, Bhattacharya P, Lee Y. Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29 Si Magnetic Resonance Imaging. Chemphyschem 19(17):2143-2147, 2018. e-Pub 2018. PMID: 29779258.
- Zacharias NM, McCullough C, Shanmugavelandy S, Lee J, Lee Y, Dutta P, McHenry J, Nguyen L, Norton W, Jones LW, Bhattacharya PK. Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer. Sci Rep 7(1):16159, 2017. e-Pub 2017. PMID: 29170516.
- Ornelas A, Zacharias-Millward N, Menter DG, Davis JS, Lichtenberger L, Hawke D, Hawk E, Vilar E, Bhattacharya P, Millward S. Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer Metastasis Rev 36(2):289-303, 2017. PMID: 28762014.
- Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC, Millward SW. Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer 16(1):824, 2016. e-Pub 2016. PMID: 27784287.
- Whiting N, Hu J, Zacharias NM, Lokesh GL, Volk DE, Menter DG, Rupaimoole R, Previs R, Sood AK, Bhattacharya P. Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. J Med Imaging (Bellingham) 3(3):036001, 2016. e-Pub 2016. PMID: 27547777.
- Zand B, Previs RA, Zacharias NM, Rupaimoole R, Mitamura T, Nagaraja AS, Guindani M, Dalton HJ, Yang L, Baddour J, Achreja A, Hu W, Pecot CV, Ivan C, Wu SY, McCullough CR, Gharpure KM, Shoshan E, Pradeep S, Mangala LS, Rodriguez-Aguayo C, Wang Y, Nick AM, Davies MA, Armaiz-Pena G, Liu J, Lutgendorf SK, Baggerly KA, Eli MB, Lopez-Berestein G, Nagrath D, Bhattacharya PK, Sood AK. Role of Increased n-acetylaspartate Levels in Cancer. J Natl Cancer Inst 108(6), 2016. e-Pub 2016. PMID: 26819345.
- Benito J, Ramirez MS, Millward NZ, Velez J, Harutyunyan KG, Lu H, Shi YX, Matre P, Jacamo R, Ma H, Konoplev S, McQueen T, Volgin A, Protopopova M, Mu H, Lee J, Bhattacharya PK, Marszalek JR, Davis RE, Bankson JA, Cortes JE, Hart CP, Andreeff M, Konopleva M. Hypoxia-activated prodrug TH-302 targets hypoxic bone marrow niches in pre-clinical leukemia models. Clin Cancer Res 22(7):1687-98, 2016. e-Pub 2015. PMID: 26603259.
- Jeong, G.; Lee, J; Gong, G.; Ko, H.; Choi, I; Seo H.; Lee, Y; Zacharias Millward N; Bhattacharya, P. Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo. Journal of Industrial and Engineering Chemistry 36:224. e-Pub 2016.
- Zacharias, NM, McCullough CR, Wagner S, Sailasuta N, Chan HR, Lee Y, Hu J, Perman WH, Henneberg C, Ross BD, Bhattacharya P,. Towards Real-Time Metabolic Profiling of Cancer with Hyperpolarized Succinate. Journal of Molecular Imaging & Dynamics. e-Pub 2016.
- Rupaimoole R, Lee J, Haemmerle M, Ling H, Previs RA, Pradeep S, Wu SY, Ivan C, Ferracin M, Dennison JB, Millward NM, Nagaraja AS, Gharpure KM, McGuire M, Sam N, Armaiz-Pena GN, Sadaoui NC, Rodriguez-Aguayo C, Calin GA, Drapkin RI, Kovacs J, Mills GB, Zhang W, Lopez-Berestein G, Bhattacharya PK, Sood AK. Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. Cell Rep 13(11):2395-402, 2015. e-Pub 2015. PMID: 26686630.
- Whiting N, Hu J, Shah JV, Cassidy MC, Cressman E, Millward NZ, Menter DG, Marcus CM, Bhattacharya PK. Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles. Sci Rep 5:12842, 2015. e-Pub 2015. PMID: 26239953.
- Zacharias NM, Lee, Y, Piwnica-Worms, D, Bhattacharya, PK. Chemical Reaction-Induced Multi-molecular Polarization (CRIMP). Chemical Communication 50:13030-13033, 2014. PMID: 25224323.
- Zacharias NM, Chan HR, Sailasuta N, Ross BD, Bhattacharya P. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate. J Am Chem Soc 134(2):934-43, 2012. e-Pub 2011. PMID: 22146049.
- Bhattacharya P, Chekmenev EY, Reynolds WF, Wagner S, Zacharias N, Chan HR, Bünger R, Ross BD. Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice. NMR Biomed 24(8):1023-8, 2011. e-Pub 2011. PMID: 21538638.
- Eastwood AL, Blum AP, Zacharias NM, Dougherty DA. A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters. J Org Chem 74(23):9241-4, 2009. PMID: 19902952.
- Petersson EJ, Brandt GS, Zacharias NM, Dougherty DA, Lester HA. Caging proteins through unnatural amino acid mutagenesis. Methods Enzymol 360:258-73, 2003. PMID: 12622154.
- Beene DL, Brandt GS, Zhong W, Zacharias NM, Lester HA, Dougherty DA. Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. Biochemistry 41(32):10262-9, 2002. PMID: 12162741.
- Zacharias N, Dougherty DA. Cation-pi interactions in ligand recognition and catalysis. Trends Pharmacol Sci 23(6):281-7, 2002. PMID: 12084634.
- Li, L, Zhong, Z, Zacharias, N, Gibbs, C. Lester, HA, Dougherty, DA. The tethered agonist approach to mapping ion channel proteins - towards a structural model for the agonist binding site of the nicotinic acetylcholine receptor. Chemistry and Biology 8:47-58, 2001. PMID: 11182318.
- Bekele H, Nesloney CL, McWilliams KW, Zacharias NM, Chitnumsub P, Kelly JW. Improved Synthesis of the Boc and Fmoc Derivatives of 4-(2'-Aminoethyl)-6-dibenzofuranpropionic Acid: An Unnatural Amino Acid That Nucleates beta-Sheet Folding. J Org Chem 62(7):2259-2262, 1997. PMID: 11671538.
Invited Articles
- Suto MJ, Zacharias N.. Neuronal nicotinic acetylcholine receptors as drug targets. Expert Opin Ther Targets, 2004.
Grant & Contract Support
| Title: | Early detection, characterization, and monitoring efficacy of chemotherapy in prostate cancer using hyperpolarized metabolic imaging agents |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator |
| Title: | Colleen's Dream Foundation - Gift |
| Funding Source: | Colleen's Foundation |
| Role: | Principal Investigator |
| Title: | Early Detection of Pancreatic Cancer In Vivo by Molecular Imaging of Lactose-functionalized |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Anti-leukemia efficacy of the novel glutaminase inhibitor CB-839 |
| Funding Source: | Calithera Biosciences, Inc |
| Role: | Co-Investigator |
| Title: | Determining and Correlating the Metabolic Profile of Melanoma Cell Lines with iNOS Expression |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Glioblastoma Moonshot |
| Funding Source: | MD Anderson Moonshot |
| Role: | Co-Investigator |
| Title: | Intrinsic and microenvironment-modulated glutamine dependence in AML: Biology and therapeutic targeting with glutaminase inhibitors |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Non-Invasive Colonscopy by Molecular Imaging of Mucin Targeted Hyperpolarized Silicon Nanoparticles |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Development of Targeted Theranostic Nanoparticles for the Imaging and Treatment of Breast Cancer |
| Funding Source: | UT MD Anderson, Center for Radiation Oncology |
| Role: | Co-Principal Investigator |
| Title: | NCI Exploratory/Developmental Research Grant Award |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Glutamine Imaging for the Detection of Renal Cell Carcinoma Lung Metastases |
| Funding Source: | University of Texas MD Anderson Cancer Center |
| Role: | Co-Principal Investigator |
| Title: | Metabolic Inhibition of Kidney Cancer |
| Funding Source: | University of Texas MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Targeting Resistance Mechanisms in SMARCB1-Deficient Tumors |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-Investigator |
| Title: | Evolution of Hypoxia-Inducible Factor Inhibitors for Renal Cell Carcinoma |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Principal Investigator |
| Title: | Targeting Distinct Metabolic Vulnerabilities of Aggressive Renal Cell Carcinoma Variants |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified December 18, 2024