Meet R. Tyler Hillman, M.D., Ph.D.
R Tyler Hillman, M.D., Ph.D.
Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2012 | Stanford University School of Medicine, Stanford, CA, USA, MD, Medicine |
| 2010 | Stanford University School of Medicine, Stanford, CA, USA, PHD, Genetics |
| 2004 | University of California-Berkeley, Berkeley, CA, USA, BS, Bioengineering |
Postgraduate Training
| 2016-2020 | Clinical Fellowship, Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2015-2015 | Rotating Residency, Gynecologic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY |
| 2012-2016 | Clinical Residency, Obstetrics and Gynecology, University of California-San Diego, San Diego, CA |
Board Certifications
| 2022 | American Board of Obstetrics & Gynecology, Gynecologic Oncology, Subspecialty Board Certified |
| 2021 | American Board of Obstetrics & Gynecology, Obstetrics & Gynecology Board Certified |
Experience & Service
Institutional Committee Activities
Member, Education Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2020
Member, Fellowship Admissions Committee, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2017 - 2018
Member, Fellowship Planning Committee, The University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology and Reproductive Medicine, 2016 - 2017
Member, Medication Use Safety Team Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2018
Honors & Awards
| 2020 | CPRIT Scholar in Cancer Research, Cancer Prevention and Research Institute of Texas |
| 2019 | Administrative Chief Fellow, The University of Texas MD Anderson Cancer Center |
| 2019 | Wall of Science Inductee, The University of Texas MD Anderson Cancer Center |
| 2018 | Invited Scientific Speaker, NRG Oncology Rare Tumor Subcommittee, Philadelphia, PA |
| 2018 | The Diane Denison Tobola Endowed Fellowship in Ovarian Cancer Research, The University of Texas MD Anderson Cancer Center |
| 2018 | Best Oral Presentation Award, Gynecologic Oncology National Fellows Forum |
| 2018 | Gynecologic Oncology Fellowship Program Service to Education, The University of Texas MD Anderson Cancer Center |
| 2017 | American Society of Clinical Oncology Merit Award, American Society of Clinical Oncology |
| 2016 | Resident Achievement Award, The Society of Laparoendoscopic Surgeons |
| 2010 | Outstanding Poster Presentation Award, Medical Student Research Symposium, Stanford University School of Medicine |
| 2009 | Bio-X Graduate Student Fellowship, Stanford University School of Medicine, Stanford, Ca |
| 2006 | Student Delegate, Academy of Achievement Summit, Los Angeles, Ca |
| 2005 | Howard Hughes Medical Institute Student Research Fellow, Stanford University School of Medicine, Stanford, CA |
| 2004 | Member, Phi Beta Kappa, California Alpha Chapter, Berkeley, CA |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Hillman RT, Gershenson D. Sex cord-stromal tumors of the ovary: road map for progress. Int J Gynecol Cancer 31(2):169-170, 2021. e-Pub 2021. PMID: 33436449.
- Hillman RT Iniesta MD, Shi Q, Suki T, Chen T, Cain K, Williams L, Wang XS, Taylor JS, Mena G, Lasala J, Ramirez PT, Meyer LA. Longitudinal patient-reported outcomes and restrictive opioid prescribing after minimally invasive gynecologic surgery. Int J Gynecol Cancer 31(1):114-121, 2021. e-Pub 2020. PMID: 33158876.
- Carroll MR, Ramalingam P, Salvo G, Fujimoto J, Solis Soto LM, Phoolcharoen N, Hillman RT, Cardnell R, Byers L, Frumovitz M. Evaluation of PARP and PDL-1 as potential therapeutic targets for women with high-grade neuroendocrine carcinomas of the cervix. Int J Gynecol Cancer 30(9):1303-1307, 2020. e-Pub 2020. PMID: 32727929.
- Hillman RT, Cardnell R, Fujimoto J, Lee WC, Zhang J, Byers LA, Ramalingam P, Leitao M, Swisher E, Futreal PA, Frumovitz M. Comparative genomics of high grade neuroendocrine carcinoma of the cervix. PLoS One 15(6):e0234505, 2020. e-Pub 2020. PMID: 32544169.
- Hillman RT, Sanchez-Migallon A, Meyer LA, Iniesta MD, Cain KE, Siverand AM, Veum SPL, Suki TS, Lasala JD, Ramirez PT. Patient characteristics and opioid use prior to discharge after open gynecologic surgery in an enhanced recovery after surgery (ERAS) program. Gynecol Oncol 153(3):604-609, 2019. e-Pub 2019. PMID: 30902370.
- Hillman RT, Celestino J, Terranova C, Beird HC, Gumbs C, Little L, Nguyen T, Thornton R, Tippen S, Zhang J, Lu KH, Gershenson DM, Rai K, Broaddus RR, Futreal PA. KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary. Nat Commun 9(1):2496, 2018. e-Pub 2018. PMID: 29950560.
- Hillman RT, Chisholm GB, Lu KH, Futreal PA. Genomic Rearrangement Signatures and Clinical Outcomes in High-Grade Serous Ovarian Cancer. J Natl Cancer Inst 110(3), 2018. PMID: 29584920.
- Hillman RT, Saenz CC, McHale MT, Plaxe SC. Fertility preservation and survival among young women with early ovarian cancer living in US counties with gynecologic oncologist services. Int J Gynaecol Obstet 137(2):157-163, 2017. e-Pub 2017. PMID: 28170079.
- Hillman RT, Ward K, Saenz C, McHale M, Plaxe S. Barriers prevent patient access to personalized therapies identified by molecular tumor profiling of gynecologic malignancies. J Pers Med 5(2):165-73, 2015. e-Pub 2015. PMID: 26011384.
- Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA. The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev Cell 33(1):22-35, 2015. e-Pub 2015. PMID: 25816987.
- Hillman RT, Chin HG, Mody SK. Management of Second Trimester Fetal Demise in a Noncommunicating Uterine Horn. Case Rep Obstet Gynecol 2015:927037, 2015. e-Pub 2015. PMID: 26146578.
- Hillman RT, Garabedian MJ, Wallerstein RJ. Pregnancy outcome in a woman with prune belly syndrome. BMJ Case Rep 2012, 2012. e-Pub 2012. PMID: 23203170.
- Hillman RT, Calos MP. Site-specific integration with bacteriophage ΦC31 integrase. Cold Spring Harb Protoc 2012(5), 2012. e-Pub 2012. PMID: 22550292.
- Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP. Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev 25(22):2333-46, 2011. e-Pub 2011. PMID: 22051878.
- Chavez CL, Keravala A, Woodard LE, Hillman RT, Stowe TR, Chu JN, Calos MP. Kinetics and longevity of ΦC31 integrase in mouse liver and cultured cells. Hum Gene Ther 21(10):1287-97, 2010. PMID: 20497035.
- Woodard LE, Hillman RT, Keravala A, Lee S, Calos MP. Effect of nuclear localization and hydrodynamic delivery-induced cell division on phiC31 integrase activity. Gene Ther 17(2):217-26, 2010. e-Pub 2009. PMID: 19847205.
- Chalberg TW, Portlock JL, Olivares EC, Thyagarajan B, Kirby PJ, Hillman RT, Hoelters J, Calos MP. Integration specificity of phage phiC31 integrase in the human genome. J Mol Biol 357(1):28-48, 2006. e-Pub 2005. PMID: 16414067.
- Hillman RT, Green RE, Brenner SE. An unappreciated role for RNA surveillance. Genome Biol 5(2):R8, 2004. e-Pub 2004. PMID: 14759258.
- Green RE, Lewis BP, Hillman RT, Blanchette M, Lareau LF, Garnett AT, Rio DC, Brenner SE. Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes. Bioinformatics 19 Suppl 1:i118-21, 2003. PMID: 12855447.
- Zhu BQ, Sievers RE, Browne AE, Hillman RT, Chair K, Lee RJ, Chatterjee K, Glantz SA, Parmley WW. The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke. J Renin Angiotensin Aldosterone Syst 3(1):54-60, 2002. PMID: 11984749.
Abstracts
- Hillman RT, Celestino J, Terranova C, Beird HC, Gumbs C,Little L, Nguyen T, Thornton R, Tippen S, Zhang J, Lu KH, Gershenson DM, Rai K, Broaddus RR, Futreal AP. KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary. Gynecologic Oncology National Fellows Forum, 2018.
- Hillman RT, Celestino J, Terranova C, Beird HC, Gumbs C,Little L, Nguyen T, Thornton R, Tippen S, Zhang J, Lu KH, Gershenson DM, Rai K, Broaddus RR, Futreal AP. KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary. Society of Gynecologic Oncology Annual Meeting, 2018.
- Hillman RT, Cardnell R, Fujimoto J, Byers LA, Futreal PA, Fru,ovitz M. Genomic landscape of small cell neuroendocrine cervical cancer. Society of Gynecologic Oncology Winter Meeting, 2018.
- Hillman RT, Lu KH, Futreal PA. A genomic rearrangement signature associated with poor overall survival in high grade serous ovarian cancer. Western Association of Gynecologic Oncologists annual meeting, 2017.
- Hillman RT, Lu KH, Futreal PA. A novel genomic rearrangement signature predicts poor survival among women with high grade serous ovarian cancer. American Society of Clinical Oncology annual meeting, 2017.
- Hillman RT, Dottino JA, Lu KH, Futreal PA. Endometrial cancer cell lines share genomic features with distinct TCGA-identified endometrial carcinoma subtypes. Society of Gynecologic Oncology annual meeting, 2017.
- Hillman RT, Saenz CC, McHale MT, Plaxe SC. Fertility preservation and survival among young women with early ovarian cancer living near gynecologic oncologists. Society of Gynecologic Oncology annual meeting, 2016.
- Hillman RT, Gross EA. Trial of labor after prior Cesarean versus elective repeat Cesarean: Can a single clinic visit improve patient knowledge about risks and benefits?. Society for Maternal Fetal Medicine annual meeting, 2015.
Grant & Contract Support
| Title: | Identification of genomic biomarkers of platinum resistance in BRCA mutant ovarian cancer |
| Funding Source: | Foundation for Women's Cancer, Judy's Mission Ovarian Cancer Early Detection |
| Role: | Principal Investigator |
| Title: | MD Anderson SPORE in Ovarian Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Genomic rearrangements and cis-regulatory plasticity in high grade serous ovarian cancer |
| Funding Source: | MD Anderson Physician-Scientist Program |
| Role: | Principal Investigator |
| Title: | Recruitment of First-Time, Tenure-Track Faculty Members |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | A Genomic Approach to Rational Therapy Selection in Ovarian Granulosa Cell Cancer |
| Funding Source: | MD Anderson Start Up Funds |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified June 12, 2024