Roberto Rangel, PhD
Department of Head and Neck Surgery, Division of Surgery
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Head and Neck Surgery - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2003 | Autonomous University of Nuevo Leon, School of Biological Sciences, Monterrey, MEX, PHD, Immunogology |
| 1996 | Autonomous University of Nuevo Leon, School of Medicine, Monterrey, MEX, M.Sc, Immunology |
| 1991 | Autonomous University of Tamaulipas, School of Chemistry Sciences, Reynosa, MEX, BS, Pharmaceutical Chemistry |
Postgraduate Training
| 2004-2008 | Post-doctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2003-2004 | Post-doctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX |
Experience & Service
Academic Appointments
Visiting Scientist, AMGEN Research Institute, Toronto, 2001 - 2001
Visiting Scientist, Centro Medico Nacional Siglo XXI, Mexico City, 1993 - 1993
Other Appointments/Responsibilities
Senior Research Scientist, The University of Texas MD Anderson Cancer Center (Dept. of Immunology), Houston, TX, 2016 - 2018
Senior Research Associate, The Houston Methodist Research Institute (Cancer Research Program), Houston, TX, 2012 - 2016
Research Scientist, The University of Texas MD Anderson Cancer Center (Dept. of Genitourinary Medical Oncology), Houston, TX, 2008 - 2012
Teaching Assistant, Dept. of Immunology, School of Medicine, Monterrey, 1994 - 1995
Teaching Assistant, Dept. of Clinical Analysis, School of Chemistry Sciences, Reynosa, 1990 - 1991
Institutional Committee Activities
Member, Oversight Committee for the Monoclonal Antibody Core Facility, 2016 - 2018
Honors & Awards
| 2006 | Postdoctoral Fellowship, The Susan G. Komen Breast Cancer Foundation |
| 2006 | Odyssey Scholarship, Odyssey program and Howard E. Butt Scientific Achievement Award at MD Anderson Cancer Center, Houston, TX |
| 2003 | Ph.D Dissertation, Summa cum Laude |
| 2002 | Basic Science Research Award, Mexican Government of Nuevo Leon, Mexico |
| 1999 | Pre-doctoral Fellowship, Bob R. Smith Foundation, Dept. of Immunology, MD Anderson Cancer Center, Houston, TX |
| 1996 | Basic Science Award, National Biomedical Meeting, Monterrey, Mexico |
| 1995 | Basic Science Award, National Biomedical Meeting, Monterrey, Mexico |
| 1995 | Basic Science Award, Infectious Disease Meeting, Monterrey, Mexico |
| 1994 | Basic Science Award, Regional Biomedical Meeting, Monterrey, Mexico |
| 1992 | Fellowship, National Council of Science and Technology, Monterrey, Mexico |
Selected Publications
Peer-Reviewed Articles
- Shi Y, Xie TX, Leach DG, Wang B, Young S, Osman AA, Sikora AG, Ren X, Hartgerink JD, Myers JN, Rangel R. Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model. Cancer Prev Res (Phila) 14(8):767-778, 2021. e-Pub 2021. PMID: 34021022.
- Kodama M, Kodama T, Newberg JY, Katayama H, Kobayashi M, Hanash SM, Yoshihara K, Wei Z, Tien JC, Rangel R, Hashimoto K, Mabuchi S, Sawada K, Kimura T, Copeland NG, Jenkins NA. In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer. Proc Natl Acad Sci U S A 114(35):E7301-E7310, 2017. e-Pub 2017. PMID: 28811376.
- Rangel R, Guzman-Rojas L, Kodama T, Kodama M, Newberg JY, Copeland NG, Jenkins NA. Identification of new tumor suppressor genes in triple-negative breast cancer. Cancer Res. e-Pub 2017. PMID: 28724549.
- Staquicini DI, Rangel R, Guzman-Rojas L, Staquicini FI, Dobroff AS, Tarleton CA, Ozbun MA, Kolonin MG, Gelovani JG, Marchiò S, Sidman RL, Hajjar KA, Arap W, Pasqualini R. Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting. Sci Rep 7(1):4243, 2017. e-Pub 2017. PMID: 28652618.
- Rangel R, Lee SC, Hon-Kim Ban K, Guzman-Rojas L, Mann MB, Newberg JY, Kodama T, McNoe LA, Selvanesan L, Ward JM, Rust AG, Chin KY, Black MA, Jenkins NA, Copeland NG. Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression. Proc Natl Acad Sci U S A 113(48):E7749-E7758, 2016. e-Pub 2016. PMID: 27849608.
- Kodama T, Bard-Chapeau EA, Newberg JY, Kodama M, Rangel R, Yoshihara K, Ward JM, Jenkins NA, Copeland NG. Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma. Gastroenterology 151(2):324-337.e12, 2016. e-Pub 2016. PMID: 27178121.
- Kodama T, Newberg JY, Kodama M, Rangel R, Yoshihara K, Tien JC, Parsons PH, Wu H, Finegold MJ, Copeland NG, Jenkins NA. Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma. Proc Natl Acad Sci U S A 113(24):E3384-93, 2016. e-Pub 2016. PMID: 27247392.
- Flores MS, Carrillo P, Tamez E, Rangel R, Rodríguez EG, Maldonado MG, Isibasi A, Galán L. Diagnostic parameters of serological ELISA for invasive amoebiasis, using antigens preserved without enzymatic inhibitors. Exp Parasitol 161:48-53, 2016. e-Pub 2015. PMID: 26684288.
- Dobroff AS, Rangel R, Guzman-Roja L, Salmeron CC, Gelovani JG, Sidman RL, Bologa CG, Oprea TI, Brinker CJ, Pasqualini R, Arap W. Ligand-directed profiling of organelles with internalizing phage libraries. Curr Protoc Protein Sci 79:30.4.1-30, 2015. e-Pub 2015. PMID: 25640897.
- Dondossola E, Rangel R, Guzman-Rojas L, Barbu EM, Hosoya H, St John LS, Molldrem JJ, Corti A, Sidman RL, Arap W, Pasqualini R. CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(51):20717-22, 2013. e-Pub 2013. PMID: 24297924.
- Rangel R, Dobroff AS, Guzman-Rojas L, Salmeron CC, Gelovani JG, Sidman RL, Pasqualini R, Arap W. Targeting mammalian organelles with internalizing phage (iPhage) libraries. Nat Protoc 8(10):1916-39, 2013. e-Pub 2013. PMID: 24030441.
- Barboza-Cerda MC, Campos-Acevedo LD, Rangel R, Martínez-de-Villarreal LE, Déctor MA. A novel phenotype characterized by digital abnormalities, intellectual disability, and short stature in a Mexican family maps to Xp11.4-p11.21. Am J Med Genet A 161A(2):237-43, 2013. e-Pub 2013. PMID: 23307567.
- Rangel R, Guzman-Rojas L, le Roux LG, Staquicini FI, Hosoya H, Barbu EM, Ozawa MG, Nie J, Dunner K, Langley RR, Sage EH, Koivunen E, Gelovani JG, Lobb RR, Sidman RL, Pasqualini R, Arap W. Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells. Nat Commun 3:788, 2012. e-Pub 2012. PMID: 22510693.
- Guzman-Rojas L, Rangel R, Salameh A, Edwards JK, Dondossola E, Kim YG, Saghatelian A, Giordano RJ, Kolonin MG, Staquicini FI, Koivunen E, Sidman RL, Arap W, Pasqualini R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. Proc Natl Acad Sci U S A 109(5):1637-42, 2012. e-Pub 2012. PMID: 22307623.
- Ma W, McKeller MR, Rangel R, Ortiz-Quintero B, Blackburn MR, Martinez-Valdez H. Spare PRELI gene loci: failsafe chromosome insurance?. PLoS One 7(5):e37949, 2012. e-Pub 2012. PMID: 22666421.
- Ma W, Ortiz-Quintero B, Rangel R, McKeller MR, Herrera-Rodriguez S, Castillo EF, Schluns KS, Hall M, Zhang H, Suh WK, Okada H, Mak TW, Zhou Y, Blackburn MR, Martinez-Valdez H. Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res 21(11):1564-77, 2011. e-Pub 2011. PMID: 21606955.
- McKeller MR, Herrera-Rodriguez S, Ma W, Ortiz-Quintero B, Rangel R, Candé C, Sims-Mourtada JC, Melnikova V, Kashi C, Phan LM, Chen Z, Huang P, Dunner K, Kroemer G, Singh KK, Martinez-Valdez H. Vital function of PRELI and essential requirement of its LEA motif. Cell Death Dis 1:e21, 2010. PMID: 21364629.
- Mintz PJ, Cardó-Vila M, Ozawa MG, Hajitou A, Rangel R, Guzman-Rojas L, Christianson DR, Arap MA, Giordano RJ, Souza GR, Easley J, Salameh A, Oliviero S, Brentani RR, Koivunen E, Arap W, Pasqualini R. An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment. Proc Natl Acad Sci U S A 106(7):2182-7, 2009. e-Pub 2009. PMID: 19168626.
- Tagore DM, Nolte WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R, Arap W, Lane WS, Saghatelian A. Peptidase substrates via global peptide profiling. Nat Chem Biol 5(1):23-5, 2009. e-Pub 2008. PMID: 19011639.
- Souza GR, Yonel-Gumruk E, Fan D, Easley J, Rangel R, Guzman-Rojas L, Miller JH, Arap W, Pasqualini R. Bottom-up assembly of hydrogels from bacteriophage and Au nanoparticles: the effect of cis- and trans-acting factors. PLoS One 3(5):e2242, 2008. e-Pub 2008. PMID: 18493583.
- Cardó-Vila M, Zurita AJ, Giordano RJ, Sun J, Rangel R, Guzman-Rojas L, Anobom CD, Valente AP, Almeida FC, Lahdenranta J, Kolonin MG, Arap W, Pasqualini R. A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11. PLoS One 3(10):e3452, 2008. e-Pub 2008. PMID: 18941632.
- Bover LC, Cardó-Vila M, Kuniyasu A, Sun J, Rangel R, Takeya M, Aggarwal BB, Arap W, Pasqualini R. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol 178(12):8183-94, 2007. PMID: 17548657.
- Rangel R, Sun Y, Guzman-Rojas L, Ozawa MG, Sun J, Giordano RJ, Van Pelt CS, Tinkey PT, Behringer RR, Sidman RL, Arap W, Pasqualini R. Impaired angiogenesis in aminopeptidase N-null mice. Proc Natl Acad Sci U S A 104(11):4588-93, 2007. e-Pub 2007. PMID: 17360568.
- Soghomonyan S, Hajitou A, Rangel R, Trepel M, Pasqualini R, Arap W, Gelovani JG, Alauddin MM. Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU. Nat Protoc 2(2):416-23, 2007. PMID: 17406603.
- Hajitou A, Rangel R, Trepel M, Soghomonyan S, Gelovani JG, Alauddin MM, Pasqualini R, Arap W. Design and construction of targeted AAVP vectors for mammalian cell transduction. Nat Protoc 2(3):523-31, 2007. PMID: 17406616.
- Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin MM, Marini FC, Restel BH, Ozawa MG, Moya CA, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman MD, Gelovani JG, Pasqualini R, Arap W. A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell 125(2):385-98, 2006. PMID: 16630824.
- Flores MS, Tamez-Treviño E, Castañeda F, Tijerina-Menchaca R, Galan-Wong L, Rangel R. Preparation of Entamoeba histolytica antigens without enzymatic inhibitors. Parasitology 131(Pt 2):231-6, 2005. PMID: 16145939.
- Rangel R, McKeller MR, Sims-Mourtada JC, Kashi C, Cain K, Wieder ED, Molldrem JJ, Pham LV, Ford RJ, Yotnda P, Guret C, Francés V, Martinez-Valdez H. Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript. J Biol Chem 280(18):17807-14, 2005. e-Pub 2005. PMID: 15757909.
- Sims-Mourtada JC, Bruce S, McKeller MR, Rangel R, Guzman-Rojas L, Cain K, Lopez C, Zimonjic DB, Popescu NC, Gordon J, Wilkinson MF, Martinez-Valdez H. The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. DNA Cell Biol 24(5):325-38, 2005. PMID: 15869410.
- Sims-Mourtada JC, Guzman-Rojas L, Rangel R, Nghiem DX, Ullrich SE, Guret C, Cain K, Martinez-Valdez H. In vivo expression of interleukin-8, and regulated on activation, normal, T-cell expressed, and secreted, by human germinal centre B lymphocytes. Immunology 110(3):296-303, 2003. PMID: 14632656.
- McCarthy H, Wierda WG, Barron LL, Cromwell CC, Wang J, Coombes KR, Rangel R, Elenitoba-Johnson KS, Keating MJ, Abruzzo LV. High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia. Blood 101(12):4903-8, 2003. e-Pub 2003. PMID: 12586616.
- Siddiqa A, Sims-Mourtada JC, Guzman-Rojas L, Rangel R, Guret C, Madrid-Marina V, Sun Y, Martinez-Valdez H. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. Nature 410(6826):383-7, 2001. PMID: 11268217.
- Guzman-Rojas L, Sims JC, Rangel R, Guret C, Sun Y, Alcocer JM, Martinez-Valdez H. PRELI, the human homologue of the avian px19, is expressed by germinal center B lymphocytes. Int Immunol 12(5):607-12, 2000. PMID: 10784606.
Invited Articles
- Guzman-Rojas L, Sims-Mourtada JC, Rangel R, Martinez-Valdez H. Life and death within germinal centres: a double-edged sword. Immunology 107(2):167-75, 2002. PMID: 12383195.
Other Articles
- Tamez-Trevino E, Tijerina-Menchaca R, Bosques-Padilla F, Rangel R, Isibasi A, Flores-Castaneda MS Frequency of HCV, HBV or HIV undiagnosed infection in hepatic disease patients. Medicina Universitaria 4:146-150, 2002.
Book Chapters
- Flores MS, Perez D, Monjardin B, Gonzalez D, Barrientos J, Vazquez I Gomez R, Tijerina-Menchaca G, Mendoza A, Rojo J, Viader L, Galan-Wong, Rangel R. Caracterizacion Fisicoquimica parcial de Proteinas BPM de Entamoeba histolytica. In: IV Encuentro Particpacion de la Mujer en la Ciencia. Biotecnologia y Ciencias Agropecuarias, 18-22, 2007.
Patient Reviews
CV information above last modified August 09, 2023