Scott Bright, PhD
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Instructor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
My research focus is to understand how DNA damage induced by radiotherapy can lead to radiosensitization as well as immunosensitization of cancer. We are currently exploring how small molecule inhibitors, targeting DNA repair or metabolism can be used to synergize with radiotherapy.
Education & Training
Degree-Granting Education
| 2014 | Oxford Brookes University, Oxford, GBR, PHD, Cell/Molecular Biology |
| 2009 | Oxford Brookes University, Oxford, GBR, BS, Biomedical Science |
Postgraduate Training
| 2017-2021 | Postdoctoral Fellow, Photon and Proton Radiotherapy, The University of Texas MD Anderson, Houston, TX |
| 2014-2017 | Postdoctoral Fellow, Exosome Signaling in Radiation Response, Oxford Brookes University, Oxford |
Honors & Awards
| 2018 | Science Highlights Award, American Association of Physicists in Medicine (AAPM) |
| 2017 | SIT Travel Award, Radiation Research Society |
| 2016 | Newton Award, The Royal Society |
| 2015 | DoReMi Travel Award, European Atomic Energy Community |
| 2012 | NASA Space Radiation Summer School Fellowship, NASA |
| 2011 | Early Career Investigator Award, Association for Radiation Research |
| 2009 | President's Prize, Institute of Biomedical Science |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Chapman BV, Liu D, Shen Y, Olamigoke OO, Lakomy DS, Barrera AMG, Stecklein SR, Sawakuchi GO, Bright SJ, Bedrosian I, Litton JK, Smith BD, Woodward WA, Perkins GH, Hoffman KE, Stauder MC, Strom EA, Arun BK, Shaitelman SF. Outcomes After Breast Radiation Therapy in a Diverse Patient Cohort With a Germline BRCA1/2 Mutation. Int J Radiat Oncol Biol Phys 112(2):426-436, 2022. e-Pub 2021. PMID: 34610390.
- Chapman BV, Liu D, Shen Y, Olamigoke OO, Lakomy DS, Barrera AMG, Stecklein SR, Sawakuchi GO, Bright SJ, Bedrosian I, Litton JK, Smith BD, Woodward WA, Perkins GH, Hoffman KE, Stauder MC, Strom EA, Arun BK, Shaitelman SF. Breast Radiation Therapy-Related Treatment Outcomes in Patients With or Without Germline Mutations on Multigene Panel Testing. Int J Radiat Oncol Biol Phys 112(2):437-444, 2022. e-Pub 2021. PMID: 34582940.
- Flint DB, Bright SJ, McFadden CH, Konishi T, Ohsawa D, Turner B, Lin SH, Grosshans DR, Chiu HS, Sumazin P, Shaitelman SF, Sawakuchi GO. Cell Lines of the Same Anatomic Site and Histologic Type Show Large Variability in Intrinsic Radiosensitivity and Relative Biological Effectiveness to Protons and Carbon Ions. Med Phys 48(6):3242-3261, 2021. e-Pub 2021. PMID: 33837540.
- Elbakrawy E, Kaur Bains S, Bright S, Al-Abedi R, Mayah A, Goodwin E, Kadhim M. Radiation-Induced Senescence Bystander Effect: The Role of Exosomes. Biology (Basel) 9(8):191, 2020. e-Pub 2020. PMID: 32726907.
- McFadden CH, Rahmanian S, Flint DB, Bright SJ, Yoon DS, O'Brien DJ, Asaithamby A, Abdollahi A, Greilich S, Sawakuchi GO. Isolation of Time-Dependent DNA Damage Induced by Energetic Carbon Ions and Their Fragments Using Fluorescent Nuclear Track Detectors. Med Phys 47(1):272-281, 2020. e-Pub 2019. PMID: 31677156.
- Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO. Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death. Int J Radiat Oncol Biol Phys 105(5):1119-1125, 2019. e-Pub 2019. PMID: 31425731.
- Bains SK, Chapman K, Bright S, Senan A, Kadhim M, Slijepcevic P. Effects of Ionizing Radiation on Telomere Length and Telomerase Activity in Cultured Human Lens Epithelium Cells. Int J Radiat Biol 95(1):54-63, 2019. e-Pub 2018. PMID: 29667481.
- Bright S, Kadhim M. The Future Impacts of Non-Targeted Effects. Int J Radiat Biol 94(8):727-736, 2018. e-Pub 2018. PMID: 29569509.
- Dalke C, Neff F, Bains SK, Bright S, Lord D, Reitmeir P, Rößler U, Samaga D, Unger K, Braselmann H, Wagner F, Greiter M, Gomolka M, Hornhardt S, Kunze S, Kempf SJ, Garrett L, Hölter SM, Wurst W, Rosemann M, Azimzadeh O, Tapio S, Aubele M, Theis F, Hoeschen C, Slijepcevic P, Kadhim M, Atkinson M, Zitzelsberger H, Kulka U, Graw J. Lifetime Study in Mice After Acute Low-Dose Ionizing Radiation: A Multifactorial Study with Special Focus on Cataract Risk. Radiat Environ Biophys 57(2):99-113, 2018. e-Pub 2018. PMID: 29327260.
- Szatmári T, Kis D, Bogdándi EN, Benedek A, Bright S, Bowler D, Persa E, Kis E, Balogh A, Naszályi LN, Kadhim M, Sáfrány G, Lumniczky K. Extracellular Vesicles Mediate Radiation-Induced Systemic Bystander Signals in the Bone Marrow and Spleen. Front Immunol 8:347, 2017. e-Pub 2017. PMID: 28396668.
- Al-Mayah AH, Bright SJ, Bowler DA, Slijepcevic P, Goodwin E, Kadhim MA. Exosome-Mediated Telomere Instability in Human Breast Epithelial Cancer Cells after X Irradiation. Radiat Res 187(1):98-106, 2017. e-Pub 2016. PMID: 27959588.
- Ainsbury EA, Barnard S, Bright S, Dalke C, Jarrin M, Kunze S, Tanner R, Dynlacht JR, Quinlan RA, Graw J, Kadhim M, Hamada N. Ionizing Radiation Induced Cataracts: Recent Biological and Mechanistic Developments and Perspectives for Future Research. Mutat Res Rev Mutat Res 770(Pt. B):238-261, 2016. e-Pub 2016. PMID: 27919334.
- Al-Mayah A, Bright S, Chapman K, Irons S, Luo P, Carter D, Goodwin E, Kadhim M. The Non-Targeted Effects of Radiation are Perpetuated by Exosomes. Mutat Res 772:38-45, 2015. e-Pub 2014. PMID: 25772109.
Grant & Contract Support
| Title: | Amplification of Immune Stimulation by Using Diffusing Alpha-Emitters Radiation Therapy (DaRT) and ATR Inhibition |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | Co-Investigator |
| Title: | DaRT in Combination with Inhibitors of PARP and PD-L1 to Enhance Immune Stimulation |
| Funding Source: | Alpha Tau Medical |
| Role: | Co-Investigator |
| Title: | Pre-clinical Assessment of ART0380 and ART4215 Combined with X-rays and Protons for Radiosensitization and Immune Stimulation |
| Funding Source: | Artios Pharma |
| Role: | Co-Investigator |
Patient Reviews
CV information above last modified December 12, 2023